A preparation method and production system of rare earth antibacterial material

Abstract

The present invention discloses a method for preparing a rare earth antibacterial material and a production system thereof, wherein the method for preparing a rare earth antibacterial material comprises the following steps: (a) taking a material, taking cerium oxide (CeO 2 ) 200 parts, curcumin (Cur) 1.7 parts; (b) mixing, heating and mixing cerium oxide and curcumin through a production system, the mixing time is set to 30 minutes, to form cerium oxide-loaded curcumin; (c) screening, screening the mixed cerium oxide-loaded curcumin to obtain pure cerium oxide-loaded curcumin powder. This method for preparing a rare earth antibacterial material not only has a simple preparation process, but also has good antibacterial efficacy in the prepared cerium oxide-loaded curcumin.

Description

Technical Field

[0001] The present invention relates to the technical field of rare earth antibacterial material preparation, and in particular to a rare earth antibacterial material preparation method and a production system thereof. Background Art

[0002] Rare earth antibacterial materials refer to materials that have the ability to inhibit bacterial growth and reproduction. Currently, rare earth antibacterial materials are widely used in medical, food, textile and other fields. These materials can not only provide a safe and hygienic environment, but also help reduce the spread of infectious diseases and the risk of bacterial infection.

[0003] However, with the growth of the world's population and the improvement of living standards, the spread and infection of bacteria and viruses are becoming more and more serious. Although the existing rare earth antibacterial materials have certain antibacterial and anti-inflammatory properties, the existing technical antibacterial materials are mostly made by chemical synthesis, pyrolysis or hydrolysis. Not only is the production process difficult, but also due to the high activity of the rare earth itself, the prepared rare earth antibacterial materials have the problem of poor stability. Therefore, there is an urgent need for a material with stability and antibacterial properties to solve this problem. Summary of the invention

[0004] The present invention provides a preparation method and a production system of a rare earth antibacterial material, which are used to solve the problems mentioned in the background technology that the rare earth antibacterial material in the prior art is difficult to prepare and has relatively low stability.

[0005] The technical solution of the present invention is as follows: A method for preparing a rare earth antibacterial material comprises the following steps:

[0006] (a) Taking materials, according to the mass ratio, take 200 parts of cerium oxide (CeO2) and 1.7 parts of curcumin (Cur);

[0007] (b) mixing, heating and mixing cerium oxide and curcumin by a production system, with the mixing time set to 30 minutes, to form cerium oxide-loaded curcumin;

[0008] (c) Screening: Screening the mixed cerium oxide-loaded curcumin to obtain pure cerium oxide-loaded curcumin powder.

[0009] A production system of rare earth antibacterial materials, used for preparing cerium oxide-loaded curcumin, comprising preparing a power box, a reciprocating power assembly, a mixing assembly, a loading rack and a loading assembly;

[0010] A power disk is rotatably arranged in the preparation power box;

[0011] The reciprocating power assembly is arranged between the preparation power box and the power disc;

[0012] The mixing component is arranged on the power disk through two groups of reciprocating flipping components, and the two groups of reciprocating flipping components are symmetrically arranged on the power disk, and are used to heat and prepare the rare earth antibacterial material;

[0013] The loading rack is arranged on the preparation power box;

[0014] The feeding assembly is arranged on the feeding rack and is used for feeding the rare earth antibacterial material.

[0015] On the basis of the above scheme, the reciprocating power assembly includes a power rotating rod, a power gear, a power reciprocating screw rod, a power motor and a power gear plate;

[0016] One end of the power rotating rod is arranged on the power disk, and the other end of the power rotating rod is rotatably arranged in the preparation power box;

[0017] The power gear is arranged on the power rotating rod;

[0018] The power reciprocating screw is rotatably arranged in the preparation power box, and a power ball nut group is threadedly connected to the power reciprocating screw;

[0019] The power motor is installed on one side of the power reciprocating screw rod, and the output end of the power motor is connected to one end of the power reciprocating screw rod;

[0020] The power tooth plate is arranged on the power ball nut assembly, and the power tooth plate is slidably arranged on the preparation power box, and the power tooth plate is meshed with the power gear.

[0021] As the preferred technical solution of the present application, the reciprocating turning assembly includes a turning plate, a turning rod, a turning gear, a ring-shaped reciprocating frame, a turning gear plate, a reciprocating adjustment gear plate, a turning electric cylinder, a turning half gear, a turning bevel gear 1, a steering rod, a turning bevel gear 2 and a steering gear;

[0022] The turning plate is arranged on the power disc;

[0023] The material turning rotating rod is rotatably arranged on the material turning plate;

[0024] The flipping gear is arranged on the material flipping rotating rod;

[0025] The annular reciprocating frame is slidably arranged on the power disk;

[0026] The flip gear plate is arranged on the annular reciprocating frame, and the flip gear is meshed with the flip gear;

[0027] There are two reciprocating adjustment tooth plates, which are symmetrically arranged in the annular reciprocating frame, and an adjustment cavity is formed between the two reciprocating adjustment tooth plates;

[0028] The material turning electric cylinder is installed on one side of the material turning plate, and a material turning column is rotatably arranged at the output end of the material turning electric cylinder;

[0029] The material turning half gear is arranged on the material turning column, the material turning half gear is located in the adjustment cavity, and the material turning half gear is meshed with one of the reciprocating adjustment gear plates;

[0030] The material turning bevel gear 1 is arranged on the material turning column;

[0031] The steering rod penetrates and is rotatably arranged on the power disc;

[0032] The second turning bevel gear is arranged on the steering rod, and the second turning bevel gear is meshed with the first turning bevel gear;

[0033] The steering gear is arranged on the steering lever.

[0034] On the basis of the above scheme, the mixing assembly comprises a mixing barrel, a feeding pipe, a feeding valve and a mixing inner gear ring;

[0035] The mixing barrel is arranged between the two material turning rods, and a plurality of mixing steel balls are placed in the mixing barrel;

[0036] The material delivery pipe is connected to the mixing cylinder;

[0037] The material delivery valve is installed on the material delivery pipe;

[0038] The mixing inner gear ring is arranged in the preparation power box, and the mixing inner gear ring is meshed with the steering gear.

[0039] On the basis of the above scheme, the feeding assembly includes a positioning frame, a positioning electric cylinder, a positioning frame, a feeding barrel, a blocking plate, a blocking electric cylinder and a mixing part;

[0040] The position adjustment frame is arranged on the loading frame;

[0041] The position adjustment electric cylinder is installed on the position adjustment frame;

[0042] The position adjustment frame is arranged on the output end of the position adjustment electric cylinder;

[0043] The feeding cylinder is arranged on the positioning frame, two feeding tubes are connected to the feeding cylinder, and the feeding cylinder penetrates and is slidably arranged on the feeding frame;

[0044] The baffle plate is slidably arranged on the loading rack, and the bottom of the loading cylinder is in sealing contact with the upper surface of the baffle plate;

[0045] The material blocking electric cylinder is installed on one side of the material loading rack, and the output end of the material blocking electric cylinder is connected to one end of the material blocking plate;

[0046] The mixing part is arranged in the feeding cylinder.

[0047] Further on the basis of the above scheme, the mixing part includes a mixing rotating rod, a mixing motor and a spiral mixing blade;

[0048] The mixing rotating rod is rotatably arranged in the feeding barrel;

[0049] The mixing motor is installed on the feeding cylinder, and the output end of the mixing motor is connected to one end of the mixing rotating rod;

[0050] The spiral mixing blade is arranged on the mixing rotating rod.

[0051] The working principle and beneficial effects of the present invention are:

[0052] 1. The anti-inflammatory principle of the cerium oxide-loaded curcumin prepared by the present invention is mainly that nano-cerium oxide itself has nanoenzyme activity, can be internalized by cells, and reduces the generation of reactive oxygen in cells. The curcumin molecular layer is constructed on the surface of nano-cerium oxide, which can effectively achieve the synergistic effect of the two, further inhibit the release of inflammatory mediators and reduce the infiltration of inflammatory cells. The antioxidant activity of nano-cerium oxide can reduce the inflammatory response caused by oxidative stress, while curcumin can directly inhibit the release of inflammatory signaling pathways and mediators, thereby more effectively reducing inflammation.

[0053] 2. The cerium oxide-loaded curcumin prepared by the present invention has the following main principles in terms of anti-oxidation: curcumin has significant antioxidant activity, can neutralize free radicals, cooperate with and enhance the activity of nano-cerium oxide as an antioxidant mimetic enzyme, and reduce the damage of oxidative stress to cells and tissues. The redox activity of nano-cerium oxide and the antioxidant performance of curcumin can complement each other and effectively remove various types of free radicals and other oxidizing substances.

[0054] 3. The antibacterial principle of the cerium oxide-loaded curcumin prepared by the present invention is mainly that the combination of nano-cerium oxide and curcumin molecules enhances the antibacterial effect through synergistic action, the cerium oxide carrier can provide a stable environment for curcumin and help control its release rate, the redox ability and free radical generation ability of nano-cerium oxide can enhance the antibacterial effect of curcumin, thereby achieving better antibacterial effect at a lower concentration, and curcumin and nano-cerium oxide each act on different targets of bacteria, which may reduce the development of bacterial resistance to these substances;

[0055] 4. The cerium oxide-loaded curcumin prepared by the present invention has the following anti-cancer principle: the antioxidant property of nano-cerium oxide can reduce oxidative damage in cells, making cancer cells more susceptible to the anti-tumor effect of curcumin. The synergistic loading technology of the two can help to accurately deliver curcumin to the vicinity or inside of cancer cells, increase the concentration of curcumin in cancer cells, and further enhance its anti-tumor effect.

[0056] 5. In the present invention, when preparing cerium oxide-loaded curcumin, cerium oxide and curcumin are placed in a feeding barrel through corresponding feeding tubes according to a specified ratio, and a mixing motor is started. The output end of the mixing motor drives the mixing rotating rod to rotate, and the rotation of the mixing rotating rod drives the spiral mixing blade to rotate. The rotation of the spiral mixing blade drives the cerium oxide and curcumin in the feeding barrel to move from bottom to top, so that the cerium oxide and curcumin are preliminarily mixed in the feeding barrel;

[0057] 6. In the present invention, after cerium oxide and curcumin are preliminarily mixed in the feeding barrel, the material blocking electric cylinder is started, and the movement of the output end of the material blocking electric cylinder drives the material blocking plate to move, so that the material blocking plate is separated from the bottom of the feeding barrel. At the same time, the positioning electric cylinder is started, and the output end of the positioning electric cylinder drives the positioning frame to move, and the feeding barrel is driven to move through the positioning frame, so that the bottom of the feeding barrel is connected to the feeding pipe, and then the feeding valve is opened and the mixing motor is started again, so that the output end of the mixing motor rotates in the opposite direction, and the spiral mixing blade drives the preliminarily mixed cerium oxide and curcumin to move from top to bottom through the rotation of the output end of the mixing motor, so that the cerium oxide and curcumin are introduced into the mixing barrel along the feeding pipe;

[0058] 7. In the present invention, after the preliminarily mixed cerium oxide and curcumin are introduced into the mixing barrel, the feeding assembly is reset, the feeding valve is closed at the same time, and the power motor is started. The output end of the power motor drives the power reciprocating screw to rotate, so that the power ball nut group on the power reciprocating screw performs linear reciprocating motion, the movement of the power ball nut group drives the power gear plate to perform linear reciprocating motion, the movement of the power gear plate drives the power gear to reciprocate, the rotation of the power gear drives the power rotating rod to rotate, and the power rotating rod can drive the power disk to reciprocate, and when the power disk rotates, the steering gear rotates along the inner gear ring of the mixing material, and the rotation of the steering gear drives the steering rotating rod to rotate, the rotation of the steering rotating rod drives the rotation of the bevel gear 2, the rotation of the bevel gear 2 drives the rotation of the bevel gear 1, the rotation of the bevel gear 1 drives the material turning column to rotate, and the rotation of the material turning column drives the material turning The half gear rotates, and as the turning half gear rotates, the turning half gear meshes with the two reciprocating adjustment gear plates alternately. Since the turning half gear is fixed, the reciprocating adjustment gear plate drives the annular reciprocating frame to reciprocate linearly on the power disk. The movement of the annular reciprocating frame drives the turning gear plate to move. The movement of the turning gear plate drives the turning gear to reciprocate. The rotation of the turning gear drives the turning rotating rod to rotate. The mixing barrel is driven to rotate by the rotation of the turning rotating rod. In the process of the mixing barrel driven by the power motor to reciprocate in both directions, cerium oxide and curcumin are mixed with the mixing steel balls in the mixing barrel by mutual collision. While the cerium oxide and curcumin are refined and mixed, the collision between the mixing steel balls will generate some heat. The generated heat will also accelerate the fusion between the cerium oxide and curcumin, thereby forming cerium oxide-loaded curcumin.

[0059] 8. The present invention, by setting the cooperation between the flipping half gear and the annular reciprocating frame, when the power motor drives the power disc to reciprocate, in order to increase the amplitude of the mixing barrel driven by the power disc to reciprocate, the maximum rotation angle is controlled within the range of 90°±5°, and at the same time, the frequency and angle of the mixing barrel driven by the flipping rotating rod are not affected. Under the cooperation of the flipping half gear and the annular reciprocating frame, the rotation angle of the mixing barrel driven by the flipping rotating rod can be controlled within the range of 180°±5°;

[0060] 9. According to the present invention, after cerium oxide and curcumin are prepared into cerium oxide-loaded curcumin in a mixing barrel, the feed pipe is moved to the bottom of the mixing barrel by rotating the output end of the power motor, and then the feed valve is opened to discharge the mixing steel balls and the cerium oxide-loaded curcumin from the mixing barrel together. In the process of discharging the cerium oxide-loaded curcumin, two material-turning electric cylinders can be started synchronously, and the material-turning column is driven to move by the output end of the material-turning electric cylinder, and the material-turning half gear and the material-turning bevel gear 1 are driven to move by the movement of the material-turning column, so that the material-turning bevel gear 1 is separated from the material-turning bevel gear 2, and then the power motor is started, and only the power disk is needed to drive the mixing barrel to reciprocate, thereby accelerating the discharge speed of the cerium oxide-loaded curcumin, and at the same time, under the collision between the mixing steel balls, excessive cerium oxide-loaded curcumin is prevented from adhering to the inside of the mixing barrel. BRIEF DESCRIPTION OF THE DRAWINGS

[0061] The present invention will be further described in detail below in conjunction with the accompanying drawings and specific embodiments.

[0062] Figure 1 is a preparation flow chart of the present invention;

[0063] Figure 2 The bacterial mapping of different ratios of cerium oxide-loaded curcumin and Staphylococcus aureus in the present invention;

[0064] Figure 3 The bacterial mapping of different ratios of cerium oxide-supported curcumin and Escherichia coli in the present invention;

[0065] Figure 4 It is a structural schematic diagram of a partial cross-section of the rare earth antibacterial material production system of the present invention;

[0066] Figure 5 For the present invention Figure 4 A schematic diagram of the local enlarged structure at point A in the middle;

[0067] Figure 6 For the present invention Figure 4 A schematic diagram of the local enlarged structure at B in the middle;

[0068] Figure 7 For the present invention Figure 4 A schematic diagram of the local enlarged structure at C in the middle;

[0069] Figure 8 It is a structural schematic diagram of the reciprocating power assembly in the present invention;

[0070] Fig. 9 It is a schematic diagram of the structure of the mixing component and the reciprocating turning component in the present invention;

[0071] Fig.10 It is a structural schematic diagram of the rare earth antibacterial material production system of the present invention.

[0072] In the figure: 001, reciprocating power assembly; 002, mixing assembly; 003, reciprocating turning assembly; 004, loading assembly;

[0073] 1. Prepare the power box; 2. Power plate; 3. Loading rack; 4. Power rotating rod; 5. Power gear; 6. Power reciprocating screw rod; 7. Power ball nut group; 8. Power motor; 9. Power gear plate; 10. Flipping plate; 11. Flipping rotating rod; 12. Flipping gear; 13. Annular reciprocating frame; 14. Flipping gear plate; 15. Reciprocating adjustment gear plate; 16. Flipping electric cylinder; 17. Flipping half gear; 18. Flipping Bevel gear one; 19. Steering lever; 20. Turning bevel gear two; 21. Steering gear; 22. Mixing barrel; 23. Mixing steel ball; 24. Feeding pipe; 25. Feeding valve; 26. Mixing inner gear ring; 27. Positioning frame; 28. Positioning electric cylinder; 29. ​​Positioning frame; 30. Loading barrel; 31. Baffle plate; 32. Baffle electric cylinder; 33. Mixing lever; 34. Mixing motor; 35. Spiral mixing blade. DETAILED DESCRIPTION

[0074] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention. Embodiment 1

[0075] like Figures 1 to 10 As shown, this embodiment proposes a method for preparing a rare earth antibacterial material, comprising the following steps:

[0076] (a) Take materials, 200 kg of cerium oxide (CeO2) and 1.7 kg of curcumin (Cur);

[0077] (b) mixing, heating and mixing cerium oxide and curcumin by a production system, with the mixing time set to 30 minutes, to form cerium oxide-loaded curcumin;

[0078] (c) Screening: Screening the mixed cerium oxide-loaded curcumin to obtain pure cerium oxide-loaded curcumin powder.

[0079] It should be noted that, in the screening stage, it is preferred that the mixed cerium oxide-loaded curcumin is placed in a 200-mesh sieve for vibration screening, and the screening time is controlled between 15 min ± 1 min. Embodiment 2

[0080] Embodiment 2 of the present application proposes a production system of rare earth antibacterial materials based on embodiment 1, which is used to prepare cerium oxide-loaded curcumin, including preparing a power box 1, a reciprocating power component 001, a mixing component 002, a loading rack 3 and a loading component 004.

[0081] As mentioned above, a power disk 2 is rotatably arranged in the preparation power box 1, and a reciprocating power assembly 001 is arranged between the preparation power box 1 and the power disk 2. The reciprocating power assembly 001 includes a power rotating rod 4, a power gear 5, a power reciprocating screw 6, a power motor 8 and a power gear plate 9. One end of the power rotating rod 4 is arranged on the power disk 2, and the other end of the power rotating rod 4 is rotatably arranged in the preparation power box 1. The power gear 5 is arranged on the power rotating rod 4, and the power reciprocating screw 6 is rotatably arranged in the preparation power box 1. A power ball nut group 7 is threadedly connected to the power reciprocating screw 6. The power motor 8 is installed on one side of the power reciprocating screw 6, and the output end of the power motor 8 is connected to one end of the power reciprocating screw 6. The power gear plate 9 is arranged on the power ball nut group 7, and the power gear plate 9 is slidably arranged on the preparation power box 1, and the power gear plate 9 is meshed with the power gear 5.

[0082] Specifically, the power motor 8 is started, and the output end of the power motor 8 drives the power reciprocating screw 6 to rotate, so that the power ball nut group 7 on the power reciprocating screw 6 performs linear reciprocating motion, and the movement of the power ball nut group 7 drives the power gear plate 9 to perform linear reciprocating motion, and the movement of the power gear plate 9 drives the power gear 5 to rotate back and forth, and the rotation of the power gear 5 drives the power rotating rod 4 to rotate, and the power rotating rod 4 can drive the power disk 2 to rotate back and forth.

[0083] As mentioned above, the mixing component 002 is arranged on the power disk 2 through two groups of reciprocating flipping components 003. The two groups of reciprocating flipping components 003 are symmetrically arranged on the power disk 2 for heating and preparing the rare earth antibacterial material.

[0084] Among them, the reciprocating flipping assembly 003 includes a flipping plate 10, a flipping rotating rod 11, a flipping gear 12, an annular reciprocating frame 13, a flipping tooth plate 14, a reciprocating adjustment tooth plate 15, a flipping electric cylinder 16, a flipping half gear 17, a flipping bevel gear 18, a steering rotating rod 19, a flipping bevel gear 20 and a steering gear 21. The flipping plate 10 is arranged on the power disk 2, the flipping rotating rod 11 is rotatably arranged on the flipping plate 10, the flipping gear 12 is arranged on the flipping rotating rod 11, the annular reciprocating frame 13 is slidably arranged on the power disk 2, the flipping tooth plate 14 is arranged on the annular reciprocating frame 13, the flipping gear 12 is meshed with the flipping gear 12, and the reciprocating adjustment tooth plate 15 is provided with two, two to The reciprocating gear plates 15 are symmetrically arranged in the annular reciprocating frame 13, and an adjustment cavity is formed between the two reciprocating adjustment gear plates 15. The material turning electric cylinder 16 is installed on one side of the material turning plate 10, and a material turning column is rotatably arranged at the output end of the material turning electric cylinder 16. The material turning half gear 17 is arranged on the material turning column, and the material turning half gear 17 is located in the adjustment cavity. The material turning half gear 17 is meshed with one of the reciprocating adjustment gear plates 15, and the material turning bevel gear 1 18 is arranged on the material turning column. The steering rod 19 penetrates and is rotatably arranged on the power disk 2, and the material turning bevel gear 2 20 is arranged on the steering rod 19. The material turning bevel gear 20 is meshed with the material turning bevel gear 1 18, and the steering gear 21 is arranged on the steering rod 19.

[0085] Among them, the mixing component 002 includes a mixing barrel 22, a feeding pipe 24, a feeding valve 25 and a mixing inner gear ring 26. The mixing barrel 22 is arranged between the two turning rods 11. A plurality of mixing steel balls 23 are placed in the mixing barrel 22. The feeding pipe 24 is connected to the mixing barrel 22. The feeding valve 25 is installed on the feeding pipe 24. The mixing inner gear ring 26 is arranged in the preparation power box 1, and the mixing inner gear ring 26 is meshed with the steering gear 21.

[0086] Specifically, when the power disk 2 rotates, the steering gear 21 rotates along the mixing inner gear ring 26, and the self-rotation of the steering gear 21 drives the steering lever 19 to rotate, and the rotation of the steering lever 19 drives the bevel gear 2 to rotate, and the rotation of the bevel gear 2 drives the bevel gear 1 to rotate, and the rotation of the bevel gear 1 drives the turning column to rotate, and the rotation of the turning column drives the turning half gear 17 to rotate. As the turning half gear 17 rotates, the turning half gear 17 alternately meshes with the two reciprocating adjustment tooth plates 15. Since the turning half gear 17 is fixed, the reciprocating adjustment tooth plate 15 will drive the annular reciprocating frame 13 to reciprocate linearly on the power disk 2. The movement of the compound frame 13 drives the flipping tooth plate 14 to move, and the movement of the flipping tooth plate 14 drives the flipping gear 12 to rotate back and forth. The rotation of the flipping gear 12 drives the flipping rotating rod 11 to rotate, and the rotation of the flipping rotating rod 11 drives the mixing barrel 22 to rotate. In the process of the power motor 8 driving the mixing barrel 22 to rotate back and forth in both directions, cerium oxide and curcumin are mixed with the mixing steel balls 23 in the mixing barrel 22. While the cerium oxide and curcumin are refined and mixed, the collision between the mixing steel balls 23 will generate some heat, and the generated heat will also accelerate the mixing of cerium oxide and curcumin, thereby forming cerium oxide-loaded curcumin.

[0087] As mentioned above, the loading rack 3 is arranged on the preparation power box 1, and the loading assembly 004 is arranged on the loading rack 3 for loading the rare earth antibacterial material. The loading assembly 004 includes a positioning rack 27, a positioning electric cylinder 28, a positioning frame 29, a loading barrel 30, a baffle plate 31, a baffle electric cylinder 32 and a mixing part. The positioning rack 27 is arranged on the loading rack 3, the positioning electric cylinder 28 is installed on the positioning rack 27, and the positioning frame 29 is arranged on the positioning electric cylinder 28. At the output end, a loading barrel 30 is arranged on a positioning frame 29, two loading pipes are connected to the loading barrel 30, and the loading barrel 30 passes through and is slidably arranged on the loading rack 3, a baffle plate 31 is slidably arranged on the loading rack 3, the bottom of the loading barrel 30 is in sealing contact with the upper surface of the baffle plate 31, a baffle electric cylinder 32 is installed on one side of the loading rack 3, the output end of the baffle electric cylinder 32 is connected to one end of the baffle plate 31, and the mixing part is arranged in the loading barrel 30.

[0088] Among them, the mixing part includes a mixing rod 33, a mixing motor 34 and a spiral mixing blade 35. The mixing rod 33 is rotatably set in the upper barrel 30, the mixing motor 34 is installed on the upper barrel 30, the output end of the mixing motor 34 is connected to one end of the mixing rod 33, and the spiral mixing blade 35 is set on the mixing rod 33.

[0089] Specifically, when preparing cerium oxide-loaded curcumin, cerium oxide and curcumin are placed in the upper barrel 30 through corresponding feeding tubes according to the specified ratio, and the mixing motor 34 is started. The output end of the mixing motor 34 drives the mixing rotating rod 33 to rotate, and the rotation of the mixing rotating rod 33 drives the spiral mixing blade 35 to rotate. The rotation of the spiral mixing blade 35 drives the cerium oxide and curcumin in the upper barrel 30 to move from bottom to top, so that the cerium oxide and curcumin are preliminarily mixed in the upper barrel 30.

[0090] Furthermore, after the cerium oxide and curcumin are preliminarily mixed in the loading barrel 30, the material blocking electric cylinder 32 is started, and the movement of the output end of the material blocking electric cylinder 32 drives the material blocking plate 31 to move, so that the material blocking plate 31 is separated from the bottom of the loading barrel 30. At the same time, the positioning electric cylinder 28 is started, and the output end of the positioning electric cylinder 28 drives the positioning frame 29 to move, and the loading barrel 30 is driven to move through the positioning frame 29, so that the bottom of the loading barrel 30 is connected to the feeding pipe 24, and then the feeding valve 25 is opened and the mixing motor 34 is started again, so that the output end of the mixing motor 34 rotates in the opposite direction, and the spiral mixing blade 35 drives the preliminarily mixed cerium oxide and curcumin to move from top to bottom through the rotation of the output end of the mixing motor 34, and the cerium oxide and curcumin are introduced into the mixing barrel 22 along the feeding pipe 24. Comparative Example

[0091] The preparation method and production system of the rare earth antibacterial material in Examples 1 and 2 of the present application were used to prepare cerium oxide-loaded curcumin in different proportions, wherein the preparation process and equipment were similar to those in Examples 1 and 2, except that the ratio of cerium oxide to curcumin was different. The specific preparation method was as follows:

[0092] ①. Weighing materials

[0093] Three portions of 200 kg of cerium oxide (CeO2) powder were weighed, and then 5 kg, 2.5 kg and 1.7 kg of curcumin (Cur) were weighed, respectively, and placed in a production system for mixing to form a mixture of cerium oxide (CeO2) and curcumin (Cur) with a mass ratio of 40:1, 80:1, and 120:1.

[0094] ② Select strains

[0095] Escherichia coli (No.: ATCC25922) and Staphylococcus aureus (No.: ATCC29213) were taken as test objects.

[0096] ③. Prepare the culture medium

[0097] Preparation of LB liquid culture medium: Use a measuring cylinder to measure 200 mL of distilled water and pour it into a 250 mL reagent bottle. Use an analytical electronic balance to weigh 5 g of LB broth culture medium and add it to mix well. Sterilize it in a high-temperature and high-pressure steam sterilizer at 121°C for 15 minutes and set aside for use.

[0098] Preparation of LB solid culture medium: Use a measuring cylinder to measure 400 mL of distilled water and pour it into a 500 mL reagent bottle. Use an analytical electronic balance to weigh 5 g of LB broth culture medium and 3 g of agar powder respectively. Add the above weighed reagents and mix well. Sterilize in a high-temperature and high-pressure steam sterilizer at 121°C for 15 min. When the culture medium cools to about 40-50°C, use an electric pipette to draw 15 mL of culture medium into a disposable sterile dish and let it stand to solidify.

[0099] Preparation of 1 / 500 nutrient broth medium: Use a measuring cylinder to measure 100 mL of distilled water and pour it into a 250 mL reagent bottle. Use an analytical electronic balance to weigh 1.8 g of nutrient broth medium and add it to mix and dissolve. Then use deionized water to dilute the nutrient broth 500 times. Sterilize it in a high-temperature and high-pressure steam sterilizer at 115°C for 30 minutes and set aside.

[0100] ④ Preparation of bacterial suspension

[0101] Take 8 12mL bacterial culture tubes, add 4mL LB liquid culture medium to each, pick single colonies from the solid culture medium of Staphylococcus aureus and Escherichia coli and add them to the liquid culture medium. The other tube is used as a blank control and placed in a constant temperature oscillator (37℃, 200rpm) for shaking culture overnight (15h).

[0102] ⑤、Processing of samples to be tested

[0103] The samples were divided into groups and placed in disposable culture dishes, and sterilized under ultraviolet light for 30 minutes.

[0104] ⑥. Implement grouping

[0105] Blank control (no sample added) and composite powder materials of cerium oxide loaded with curcumin at different ratios.

[0106] ⑦. Co-culture + plate spreading counting test

[0107] Use 1 / 500 nutrient broth medium to dilute Staphylococcus aureus and Escherichia coli to 10 5 CFU / mL for later use. Take 0.1g of the sample powder to be tested and mix it thoroughly with 10mL of bacterial solution. Place it in a 37℃ constant temperature incubator and culture it for 1h.

[0108] After the culture is completed, 20 μL of bacterial dilution was taken and evenly spread on LB solid culture medium using a glass spreader, and cultured in a 37°C constant temperature incubator for 24 h. The culture medium was taken out, photographed, and the number of colonies was recorded.

[0109] ⑧、Experimental results display

[0110] like Figure 2 As shown, it is the test result of Staphylococcus aureus, and the specific structure is as follows:

[0111] ,

[0112] like Figure 3 As shown, it is the test result of Escherichia coli, and the specific structure is as follows:

[0113] ,

[0114] Note: The colony counts are the colony counts under the corresponding treatment conditions of each group. If no colonies grow under the most suitable culture environment, it proves that the sample has an obvious antibacterial effect.

[0115] Antibacterial rate = (1-concentration of bacterial solution in the experimental group / concentration of bacterial solution in the control group) × 100%.

[0116] Therefore, from the above antibacterial effect, the mixture of cerium oxide (CeO2) and curcumin (Cur) formed in a mass ratio of 120:1 has the best antibacterial effect.

[0117] The above are only preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A method for preparing a rare earth antibacterial material, characterized in that: The following steps are involved: (a) taking materials, according to the mass ratio, taking 200 parts of cerium oxide and 1.7 parts of curcumin; (b) mixing, heating and mixing cerium oxide and curcumin by a production system, with the mixing time set to 30 minutes, to form cerium oxide-loaded curcumin; (c) screening, screening the mixed cerium oxide-loaded curcumin to obtain pure cerium oxide-loaded curcumin powder; A production system of rare earth antibacterial materials, used for preparing the cerium oxide-loaded curcumin, comprising: A power box (1) is prepared, wherein a power disk (2) is rotatably arranged in the power box (1); A reciprocating power assembly (001), wherein the reciprocating power assembly (001) is arranged between the preparation power box (1) and the power disk (2); A mixing component (002), the mixing component (002) being arranged on the power disk (2) via two groups of reciprocating flipping components (003), the two groups of reciprocating flipping components (003) being symmetrically arranged on the power disk (2), and being used for heating and preparing the rare earth antibacterial material; A loading rack (3), the loading rack (3) being arranged on the preparation power box (1); A loading component (004), the loading component (004) being arranged on the loading rack (3) and used for loading rare earth antibacterial materials; The reciprocating power assembly (001) comprises: A power rotating rod (4), one end of the power rotating rod (4) being arranged on the power disk (2), and the other end of the power rotating rod (4) being rotatably arranged in the preparation power box (1); A power gear (5), wherein the power gear (5) is arranged on the power rotating rod (4); A power reciprocating screw rod (6), the power reciprocating screw rod (6) being rotatably disposed in the preparation power box (1), and a power ball nut assembly (7) being threadedly connected to the power reciprocating screw rod (6); A power motor (8), the power motor (8) being mounted on one side of the power reciprocating screw rod (6), the output end of the power motor (8) being connected to one end of the power reciprocating screw rod (6); A power tooth plate (9), the power tooth plate (9) being arranged on the power ball nut assembly (7), and the power tooth plate (9) being slidably arranged on the preparation power box (1), and the power tooth plate (9) being meshed with the power gear (5); The reciprocating turnover assembly (003) comprises: a material turning plate (10), wherein the material turning plate (10) is arranged on the power disk (2); a material turning rotating rod (11), the material turning rotating rod (11) being rotatably disposed on the material turning plate (10); a turning gear (12), wherein the turning gear (12) is arranged on the material turning rotating rod (11); an annular reciprocating frame (13), the annular reciprocating frame (13) being slidably disposed on the power disk (2); A flip tooth plate (14), the flip tooth plate (14) being arranged on the annular reciprocating frame (13), the flip gear (12) being meshed with the flip gear (12); A reciprocating adjustment toothed plate (15), wherein two reciprocating adjustment toothed plates (15) are provided, and the two reciprocating adjustment toothed plates (15) are symmetrically arranged in the annular reciprocating frame (13), and an adjustment cavity is formed between the two reciprocating adjustment toothed plates (15); A material turning electric cylinder (16), the material turning electric cylinder (16) being mounted on one side of the material turning plate (10), and a material turning column being rotatably arranged at the output end of the material turning electric cylinder (16); a material turning half gear (17), the material turning half gear (17) being arranged on the material turning column, the material turning half gear (17) being located in the adjustment cavity, and the material turning half gear (17) being meshed with one of the reciprocating adjustment toothed plates (15); A material turning bevel gear (18), wherein the material turning bevel gear (18) is arranged on the material turning column; A steering rod (19), the steering rod (19) passing through and rotatably disposed on the power disk (2); A second material turning bevel gear (20), wherein the second material turning bevel gear (20) is disposed on the steering rod (19), and the second material turning bevel gear (20) is meshed with the first material turning bevel gear (18); A steering gear (21), wherein the steering gear (21) is arranged on the steering lever (19); The mixing component (002) comprises: A mixing barrel (22), the mixing barrel (22) being arranged between the two material turning rods (11), and a plurality of mixing steel balls (23) being placed in the mixing barrel (22); a material delivery pipe (24), the material delivery pipe (24) being connected to the mixing barrel (22); A material delivery valve (25), wherein the material delivery valve (25) is installed on the material delivery pipe (24); A mixing internal gear ring (26), wherein the mixing internal gear ring (26) is arranged in the preparation power box (1), and the mixing internal gear ring (26) is meshed with the steering gear (21).

2. The method for preparing a rare earth antibacterial material according to claim 1, characterized in that: The feeding assembly (004) comprises: A positioning frame (27), wherein the positioning frame (27) is arranged on the loading frame (3); A position adjusting electric cylinder (28), wherein the position adjusting electric cylinder (28) is mounted on the position adjusting frame (27); A positioning frame (29), the positioning frame (29) being arranged on an output end of the positioning electric cylinder (28); A loading cylinder (30), the loading cylinder (30) being arranged on the positioning frame (29), the loading cylinder (30) being connected to two loading pipes, and the loading cylinder (30) penetrating and slidably arranged on the loading frame (3); a material baffle plate (31), the material baffle plate (31) being slidably disposed on the material loading rack (3), the bottom of the material loading cylinder (30) being in sealing contact with the upper surface of the material baffle plate (31); A material-blocking electric cylinder (32), the material-blocking electric cylinder (32) being mounted on one side of the material loading rack (3), the output end of the material-blocking electric cylinder (32) being connected to one end of the material-blocking plate (31); A material mixing section, wherein the material mixing section is arranged in the upper barrel (30).

3. The method for preparing a rare earth antibacterial material according to claim 2, characterized in that: The mixing unit comprises: A mixing rotating rod (33), the mixing rotating rod (33) being rotatably disposed in the feeding barrel (30); A mixing motor (34), the mixing motor (34) being mounted on the loading barrel (30), the output end of the mixing motor (34) being connected to one end of the mixing rotating rod (33); A spiral mixing blade (35), wherein the spiral mixing blade (35) is arranged on the mixing rotating rod (33).

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