Traditional Chinese medicine composition spray for treating rhinitis and chronic nasosinusitis

Abstract

The invention relates to the technical field of traditional Chinese medicines, and particularly discloses a traditional Chinese medicine composition spray for treating rhinitis and chronic nasosinusitis, which is prepared from the following raw material medicine components in parts by weight: 1-30 parts of magnolia flower, 1-16 parts of cocklebur fruit, 1-60 parts of angelica dahurica, 1-30 parts of astragalus membranaceus, 1-40 parts of mint and 1-30 parts of clove. Respectively extracting the six medicinal raw materials until the purity is 90%, and taking extracts for later use; secondly, weighing 46g of the extracts according to the formula proportion, diluting to 2000ml, adding propylene glycol or glycerol accounting for 5% of the total amount or 0.35% of chloroethyl gluconate, and uniformly stirring; finally, subpackaging 100 bottles of rhinitis spray into the mixed liquid medicine in the step S2 according to 20ml per bottle, and the traditional Chinese medicine composition spray prepared from the six medicine raw materials has the beneficial effects that the clinical treatment effect on rhinitis and chronic nasosinusitis is relatively good, the discomfort and side effects of the nasal cavity are not caused, the side effects of hormone in the whole body are not caused, the effect is quick, and no side effects exist.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition spray for treating rhinitis and chronic sinusitis. Background Art

[0002] At present, in the treatment of rhinitis and chronic sinusitis, the clinical treatment effect of Western medicine is not satisfactory, which is easy to cause nasal discomfort and side effects, and even cause systemic hormone side effects, and cannot well meet the needs of the majority of patients with rhinitis and chronic sinusitis for the treatment of rhinitis and chronic sinusitis without side effects. Therefore, it is urgent to develop products that are quick in effect and have no side effects to treat rhinitis and chronic sinusitis. Summary of the invention

[0003] In order to effectively solve the problems in the background technology and overcome the technical defects in the prior art, the present invention provides the following technical solutions:

[0004] A Chinese medicine composition spray for treating rhinitis and chronic sinusitis is prepared from the following raw material drug components in weight ratio: 1-30 parts of magnolia, 1-16 parts of xanthium sibiricum, 1-60 parts of angelica dahurica, 1-30 parts of astragalus, 1-40 parts of mint and 1-30 parts of clove.

[0005] As a preferred technical solution of the present invention, it is made of the following raw material drug components in the following weight ratio: 1 part of magnolia, 1 part of Xanthium sibiricum, 1 part of angelica dahurica, 1 part of astragalus, 1 part of mint, and 1 part of clove.

[0006] As a preferred technical solution of the present invention, it is made of the following raw material drug components in the following weight ratio: 15 parts of magnolia, 8 parts of Xanthium sibiricum, 30 parts of angelica dahurica, 15 parts of astragalus, 20 parts of mint, and 15 parts of cloves.

[0007] As a preferred technical solution of the present invention, it is made of the following raw material drug components in the following weight ratio: 28 parts of magnolia, 15 parts of Xanthium sibiricum, 56 parts of angelica dahurica, 30 parts of astragalus, 38 parts of mint, and 29 parts of cloves.

[0008] A method for preparing a Chinese medicine composition spray for treating rhinitis and chronic sinusitis comprises the following steps:

[0009] S1: Extract the six drug raw materials to a purity of 90% respectively, and keep the extracts for later use;

[0010] S2: Weigh 46 g of the above extract according to the formula ratio, dilute to 2000 ml, add 5% of the total amount of propylene glycol or glycerol or 0.35% of chloroethidine gluconate and stir evenly;

[0011] S3: Divide the mixed liquid medicine in S2 into 100 bottles of nasal spray at 20 ml per bottle.

[0012] As a preferred technical solution of the present invention, the extraction method of the six drug raw material extracts in S1 is as follows:

[0013] Take a drug raw material, add 50-70% ethanol to extract twice, evaporate the ethanol, add it to a D101 resin column, after adsorption, rinse with 5 times column volume of clean water, then clean the column with 0.1-1% NaOH, wash with clean water until neutral, flush the column with 10-30% ethanol, then wash the column with 50-90% ethanol and collect, evaporate the ethanol, and dry to obtain the corresponding drug raw material extract;

[0014] As above, six kinds of drug raw material extracts were extracted in sequence.

[0015] As a preferred technical solution of the present invention, the extraction method of the six drug raw material extracts in S1 is as follows:

[0016] Take a drug raw material, add water to extract twice, concentrate and extract with water-saturated n-butanol, take the n-butanol layer liquid, evaporate the n-butanol, wash with anhydrous ethanol, and dry to obtain the corresponding drug raw material extract;

[0017] As above, six kinds of drug raw material extracts were extracted in sequence.

[0018] Compared with the prior art, the present invention has the following beneficial effects:

[0019] The Chinese medicine composition spray prepared by the six medicinal raw materials of the present invention has a good clinical therapeutic effect on rhinitis and chronic sinusitis, will not cause nasal discomfort and side effects, and will not cause systemic hormone side effects. It has a fast effect and no side effects, and can well meet the needs of the majority of patients with rhinitis and chronic sinusitis for the treatment of rhinitis and chronic sinusitis without side effects.

[0020] In the present invention:

[0021] Magnolia: pungent and warm, dispels evil, clears the orifices and reduces swelling. Magnolia flower has the functions of dispersing the lungs, dispersing evil, clearing the orifices and promoting diuresis and reducing swelling. It is an important medicine for dredging the nasal orifices.

[0022] Xanthium sibiricum: pungent, dispersing, bitter, dry, warm and unblocking, sweet and mild without being harsh, enters the lung meridian, dispels wind-cold and unclogs the nasal passages.

[0023] Angelica dahurica: pungent in nature and flavor, warm. Enters the stomach, large intestine, and lung meridians. Functions and indications: dispels cold, dispels wind and relieves pain, clears the nasal passages, dries dampness and stops leukorrhea, reduces swelling and discharges pus. Used for colds and headaches, brow pain, nasal congestion and runny nose, allergic rhinitis, sinusitis, toothache, leukorrhea, and sores and swelling.

[0024] Astragalus: sweet in nature and slightly warm. Enters the lung and spleen meridians. Functions and indications: replenishes qi and raises yang, consolidates the exterior and stops sweating, promotes diuresis and reduces swelling, promotes the production of body fluids and nourishes blood, relieves stagnation and relieves numbness, removes toxins and discharges pus, and heals sores and promotes tissue regeneration. Used for qi deficiency and fatigue, poor appetite and loose stools, sinking of qi in the middle, chronic diarrhea and prolapse of the anus, bloody stool and metrorrhagia, spontaneous sweating due to exterior deficiency, edema due to qi deficiency, internal heat and thirst, sallow complexion due to blood deficiency, hemiplegia, pain and numbness in the arthralgia, carbuncle that is difficult to heal, and carbuncle that does not heal for a long time.

[0025] Peppermint: Peppermint is pungent and cool in nature, and it enters the lung and liver meridians. It is pungent and dispersing, fragrant and purgative, and cool and refreshing. It enters the lung and liver meridians, dispersing wind-heat and clearing the head, eyes, throat, and rash, and it also soothes the liver, relieves depression, and dispels filth. It has a strong sweating ability, especially good at clearing the head. It is most suitable for treating wind-heat attacking the surface or upward attack, and can be used to treat liver depression and heat.

[0026] Clove: spicy, warm in nature. Enters the spleen, stomach, lung, and kidney meridians. It has the effects of warming the middle and lowering adverse reactions, tonifying the kidney and supporting yang. It is used for spleen and stomach deficiency and cold, hiccups and vomiting, poor appetite, vomiting and diarrhea, cold pain in the heart and abdomen, and impotence due to kidney deficiency. DETAILED DESCRIPTION

[0027] In order to make the purpose, technical solution and advantages of the present invention clearer, the technical solution in the embodiment of the present invention will be further clearly and completely described below. Obviously, the described embodiment is only a part of the embodiment of the present invention, not all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0028] Embodiment 1:

[0029] A Chinese medicine composition spray for treating rhinitis and chronic sinusitis is prepared from the following raw material drug components in weight ratio: 1 part of magnolia, 1 part of xanthium sibiricum, 1 part of angelica dahurica, 1 part of astragalus, 1 part of mint and 1 part of clove.

[0030] A method for preparing a Chinese medicine composition spray for treating rhinitis and chronic sinusitis comprises the following steps:

[0031] S1: Extract the six drug raw materials to a purity of 90% respectively, and keep the extracts for later use;

[0032] Specifically, the extraction methods of the six drug raw material extracts are as follows:

[0033] Take a drug raw material, add 50-70% ethanol to extract twice, evaporate the ethanol, add it to a D101 resin column, after adsorption, rinse with 5 times column volume of clean water, then clean the column with 0.1-1% NaOH, wash with clean water until neutral, flush the column with 10-30% ethanol, then wash the column with 50-90% ethanol and collect, evaporate the ethanol, and dry to obtain the corresponding drug raw material extract;

[0034] As above, six kinds of drug raw material extracts were extracted in sequence.

[0035] S2: According to the formula ratio (1 part of magnolia, 1 part of Xanthium sibiricum, 1 part of Angelica dahurica, 1 part of Astragalus, 1 part of mint, 1 part of clove), weigh 46 grams of the above extracts, dilute to 2000 ml, add 5% of the total amount of propylene glycol or glycerol or 0.35% of chloroethidine gluconate and stir evenly;

[0036] S3: Divide the mixed liquid medicine in S2 into 100 bottles of nasal spray at 20 ml per bottle.

[0037] Embodiment 2:

[0038] A Chinese medicine composition spray for treating rhinitis and chronic sinusitis is made from the following raw material drug components in the following weight ratio: 15 parts of magnolia, 8 parts of Xanthium sibiricum, 30 parts of angelica dahurica, 15 parts of astragalus, 20 parts of mint, and 15 parts of clove.

[0039] A method for preparing a Chinese medicine composition spray for treating rhinitis and chronic sinusitis comprises the following steps:

[0040] S1: Extract the six drug raw materials to a purity of 90% respectively, and keep the extracts for later use;

[0041] Specifically, the extraction methods of the six drug raw material extracts are as follows:

[0042] Take a drug raw material, add 50-70% ethanol to extract twice, evaporate the ethanol, add it to a D101 resin column, after adsorption, rinse with 5 times column volume of clean water, then clean the column with 0.1-1% NaOH, wash with clean water until neutral, flush the column with 10-30% ethanol, then wash the column with 50-90% ethanol and collect, evaporate the ethanol, and dry to obtain the corresponding drug raw material extract;

[0043] As above, six kinds of drug raw material extracts were extracted in sequence.

[0044] S2: According to the formula ratio (15 parts of magnolia, 8 parts of Xanthium sibiricum, 30 parts of Angelica dahurica, 15 parts of Astragalus, 20 parts of mint, 15 parts of clove), weigh 46 grams of the above extracts, dilute to 2000 ml, add 5% of the total amount of propylene glycol or glycerol or 0.35% of chloroethidine gluconate and stir evenly;

[0045] S3: Divide the mixed liquid medicine in S2 into 100 bottles of nasal spray at 20 ml per bottle.

[0046] Embodiment 3:

[0047] A Chinese medicine composition spray for treating rhinitis and chronic sinusitis is made from the following raw material drug components in the following weight ratio: 28 parts of magnolia, 15 parts of Xanthium sibiricum, 56 parts of angelica dahurica, 30 parts of astragalus, 38 parts of mint, and 29 parts of clove.

[0048] A method for preparing a Chinese medicine composition spray for treating rhinitis and chronic sinusitis comprises the following steps:

[0049] S1: Extract the six drug raw materials to a purity of 90% respectively, and keep the extracts for later use;

[0050] Specifically, the extraction methods of the six drug raw material extracts are as follows:

[0051] Take a drug raw material, add 50-70% ethanol to extract twice, evaporate the ethanol, add it to a D101 resin column, after adsorption, rinse with 5 times column volume of clean water, then clean the column with 0.1-1% NaOH, wash with clean water until neutral, flush the column with 10-30% ethanol, then wash the column with 50-90% ethanol and collect, evaporate the ethanol, and dry to obtain the corresponding drug raw material extract;

[0052] As above, six kinds of drug raw material extracts were extracted in sequence.

[0053] S2: According to the formula ratio (28 parts of magnolia, 15 parts of Xanthium sibiricum, 56 parts of Angelica dahurica, 30 parts of Astragalus, 38 parts of mint, 29 parts of clove), weigh 46 grams of the above extracts, dilute to 2000 ml, add 5% of the total amount of propylene glycol or glycerol or 0.35% of chloroethidine gluconate and stir evenly;

[0054] S3: Divide the mixed liquid medicine in S2 into 100 bottles of nasal spray at 20 ml per bottle.

[0055] Embodiment 4:

[0056] A Chinese medicine composition spray for treating rhinitis and chronic sinusitis is prepared from the following raw material drug components in weight ratio: 1 part of magnolia, 1 part of xanthium sibiricum, 1 part of angelica dahurica, 1 part of astragalus, 1 part of mint and 1 part of clove.

[0057] A method for preparing a Chinese medicine composition spray for treating rhinitis and chronic sinusitis comprises the following steps:

[0058] S1: Extract the six drug raw materials to a purity of 90% respectively, and keep the extracts for later use;

[0059] Specifically, the extraction methods of the six drug raw material extracts are as follows:

[0060] Take a drug raw material, add water to extract twice, concentrate and extract with water-saturated n-butanol, take the n-butanol layer liquid, evaporate the n-butanol, wash with anhydrous ethanol, and dry to obtain the corresponding drug raw material extract;

[0061] As above, six kinds of drug raw material extracts were extracted in sequence.

[0062] S2: According to the formula ratio (1 part of magnolia, 1 part of Xanthium sibiricum, 1 part of Angelica dahurica, 1 part of Astragalus, 1 part of mint, 1 part of clove), weigh 46 grams of the above extracts, dilute to 2000 ml, add 5% of the total amount of propylene glycol or glycerol or 0.35% of chloroethidine gluconate and stir evenly;

[0063] S3: Divide the mixed liquid medicine in S2 into 100 bottles of nasal spray at 20 ml per bottle.

[0064] Embodiment 5:

[0065] A Chinese medicine composition spray for treating rhinitis and chronic sinusitis is made from the following raw material drug components in the following weight ratio: 15 parts of magnolia, 8 parts of Xanthium sibiricum, 30 parts of angelica dahurica, 15 parts of astragalus, 20 parts of mint, and 15 parts of clove.

[0066] A method for preparing a Chinese medicine composition spray for treating rhinitis and chronic sinusitis comprises the following steps:

[0067] S1: Extract the six drug raw materials to a purity of 90% respectively, and keep the extracts for later use;

[0068] Specifically, the extraction methods of the six drug raw material extracts are as follows:

[0069] Take a drug raw material, add water to extract twice, concentrate and extract with water-saturated n-butanol, take the n-butanol layer liquid, evaporate the n-butanol, wash with anhydrous ethanol, and dry to obtain the corresponding drug raw material extract;

[0070] As above, six kinds of drug raw material extracts were extracted in sequence.

[0071] S2: According to the formula ratio (15 parts of magnolia, 8 parts of Xanthium sibiricum, 30 parts of Angelica dahurica, 15 parts of Astragalus, 20 parts of mint, 15 parts of clove), weigh 46 grams of the above extracts, dilute to 2000 ml, add 5% of the total amount of propylene glycol or glycerol or 0.35% of chloroethidine gluconate and stir evenly;

[0072] S3: Divide the mixed liquid medicine in S2 into 100 bottles of nasal spray at 20 ml per bottle.

[0073] Embodiment 6:

[0074] A Chinese medicine composition spray for treating rhinitis and chronic sinusitis is made from the following raw material drug components in the following weight ratio: 28 parts of magnolia, 15 parts of Xanthium sibiricum, 56 parts of angelica dahurica, 30 parts of astragalus, 38 parts of mint, and 29 parts of clove.

[0075] A method for preparing a Chinese medicine composition spray for treating rhinitis and chronic sinusitis comprises the following steps:

[0076] S1: Extract the six drug raw materials to a purity of 90% respectively, and keep the extracts for later use;

[0077] Specifically, the extraction methods of the six drug raw material extracts are as follows:

[0078] Take a drug raw material, add water to extract twice, concentrate and extract with water-saturated n-butanol, take the n-butanol layer liquid, evaporate the n-butanol, wash with anhydrous ethanol, and dry to obtain the corresponding drug raw material extract;

[0079] As above, six kinds of drug raw material extracts were extracted in sequence.

[0080] S2: According to the formula ratio (28 parts of magnolia, 15 parts of Xanthium sibiricum, 56 parts of Angelica dahurica, 30 parts of Astragalus, 38 parts of mint, 29 parts of clove), weigh 46 grams of the above extracts, dilute to 2000 ml, add 5% of the total amount of propylene glycol or glycerol or 0.35% of chloroethidine gluconate and stir evenly;

[0081] S3: Divide the mixed liquid medicine in S2 into 100 bottles of nasal spray at 20 ml per bottle.

[0082] The results of some clinical trials of the present invention are compared as follows:

[0083] Experimental content:

[0084] 140 patients with rhinitis and chronic sinusitis were divided into seven groups, namely, Example 1 drug group, Example 2 drug group, Example 3 drug group, Example 4 drug group, Example 5 drug group, Example 6 drug group and western medicine control group, 20 people in each group. The western medicine diagnostic criteria for allergic rhinitis refer to the diagnostic criteria in the "Guidelines for Diagnosis and Treatment of Allergic Rhinitis 2015".

[0085] The drug sprays prepared in Example 1, Example 2, Example 3, Example 4, Example 5 and Example 6 and the common western medicine sprays on the market were respectively taken and sprayed nasally 3 times / day in the morning, noon and evening for the above seven groups of patients, 2 sprays / each nostril, and the course of treatment was 2 weeks. The treatment effects are shown in the following table:

[0086] Comparison table of clinical treatment effects of Example 1-6 groups and western medicine control group:

[0087] Group cure Significant efficient invalid Total Effectiveness Example 1 Drug Group 15 3 1 1 95％ Example 2 Drug Group 16 1 2 1 95％ Example 3 Drug Group 18 1 1 0 100％ Example 4 Drug Group 17 1 1 1 95％ Example 5 Drug Group 16 2 1 1 95％ Example 6 Drug Group 17 1 2 0 100％ Western medicine control group 5 2 7 6 70％

[0088] It can be seen from the above table that the overall therapeutic efficacy of the Chinese medicine composition spray for treating rhinitis and chronic sinusitis of the present invention is much higher than that of the Western medicine control group. Clinical observations show that the Chinese medicine composition spray of the present invention not only has a quick effect but also has no side effects. It will not cause nasal discomfort and side effects, and will not cause systemic hormone side effects. The clinical treatment effect is good and can better meet the treatment needs of patients.

[0089] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A Chinese medicine composition spray for treating rhinitis and chronic sinusitis, Features: The invention is prepared from the following raw material medicine components in weight proportion: 1-30 parts of magnolia, 1-16 parts of xanthium sibiricum, 1-60 parts of angelica dahurica, 1-30 parts of astragalus, 1-40 parts of mint and 1-30 parts of clove.

2. The Chinese medicine composition spray for treating rhinitis and chronic sinusitis according to claim 1, Features: The invention is prepared from the following raw material drug components in the following weight ratio: 1 part of magnolia, 1 part of xanthium sibiricum, 1 part of angelica dahurica, 1 part of astragalus, 1 part of mint and 1 part of clove.

3. The Chinese medicine composition spray for treating rhinitis and chronic sinusitis according to claim 1, Features: The invention is prepared from the following raw material drug components in the following weight ratio: 15 parts of magnolia, 8 parts of xanthium sibiricum, 30 parts of angelica dahurica, 15 parts of astragalus, 20 parts of mint and 15 parts of clove.

4. The Chinese medicine composition spray for treating rhinitis and chronic sinusitis according to claim 1, Features: The invention is prepared from the following raw material drug components in the following weight ratio: 28 parts of magnolia, 15 parts of xanthium sibiricum, 56 parts of angelica dahurica, 30 parts of astragalus, 38 parts of mint and 29 parts of clove.

5. A method for preparing a Chinese medicine composition spray for treating rhinitis and chronic sinusitis according to any one of claims 1 to 4, Features: The following steps are involved: S1: Extract the six drug raw materials to a purity of 90% respectively, and keep the extracts for later use; S2: Weigh 46 g of the above extract according to the formula ratio, dilute to 2000 ml, add 5% of the total amount of propylene glycol or glycerol or 0.35% of chloroethidine gluconate and stir evenly; S3: Divide the mixed liquid medicine in S2 into 100 bottles of nasal spray at 20 ml per bottle.

6. The method for preparing the Chinese medicine composition spray for treating rhinitis and chronic sinusitis according to claim 5, Features: The extraction methods of the six drug raw material extracts in S1 are as follows: Take a drug raw material, add 50-70% ethanol to extract twice, evaporate the ethanol, add it to a D101 resin column, after adsorption, rinse with 5 times column volume of clean water, then clean the column with 0.1-1% NaOH, wash with clean water until neutral, flush the column with 10-30% ethanol, then wash the column with 50-90% ethanol and collect, evaporate the ethanol, and dry to obtain the corresponding drug raw material extract; As above, six kinds of drug raw material extracts were extracted in sequence.

7. The method for preparing the Chinese medicine composition spray for treating rhinitis and chronic sinusitis according to claim 5, Features: The extraction methods of the six drug raw material extracts in S1 are as follows: Take a drug raw material, add water to extract twice, concentrate and extract with water-saturated n-butanol, take the n-butanol layer liquid, evaporate the n-butanol, wash with anhydrous ethanol, and dry to obtain the corresponding drug raw material extract; As above, six kinds of drug raw material extracts were extracted in sequence.