Intra-bladder perfusion device and method
By designing devices such as wrapping tubes, perfusion tubes, extraction tubes and thermostats, combined with reverse gel chemotherapy drugs and magnetron robots, the problem of maintaining chemotherapy drug concentration is solved, improving the adhesion of drugs in the bladder and chemotherapy effects, and reducing the effect of chemotherapy in vivo Urethral injury ensures the effectiveness and comfort of treatment.
Patent Information
- Application Number
- CN202411413675.9
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-10-10
- Publication Date
- 2024-12-06
- Estimated Expiration
- Not applicable · inactive patent
AI Technical Summary
The existing intravesical perfusion devices cannot effectively ensure the treatment concentration of chemotherapy drugs in the bladder, resulting in a significant reduction in the effect of chemotherapy.
A intravesical perfusion device including wrapping tubes, perfusion tubes, extraction tubes, thermostats and syringes was designed. Through reverse gel chemotherapy drugs and magnetron robots, the drug was used as a carrier to use temperature-sensitive polymers to provide the drug at body temperature. Release slowly and move up and down the bladder wall through magnetrons to ensure even adhesion and sustained release of the drug.
It improves the adhesion of the drug to the bladder wall and chemotherapy effect, reduces the spread of the drug in the urethra, avoids urethra chemical damage, and ensures the patient's comfort and treatment effect through real-time pressure detection and adjustment.
Smart Images
Figure CN119075159A_ABST
Abstract
Description
Technical Field
[0001] The invention relates to the technical field of bladder cancer surgery recovery, and in particular to an intra-bladder instillation device and method. Background Art
[0002] Bladder cancer is the most common malignant tumor of the urinary system, which is divided into non-muscle invasive bladder cancer (NMIBC) or muscle invasive bladder cancer (MIBC). Most bladder cancers are non-muscle invasive at onset. The current standard treatment strategy for NMIBC is transurethral resection of bladder tumor (TURBT), followed by intravesical instillation of chemotherapy drugs to achieve the purpose of both tumor removal and bladder function preservation. Treatments for bladder cancer also include local bladder radiotherapy, systemic intravenous chemotherapy, systemic PD1 / PDL1 immunotherapy, and transurethral minimally invasive surgery or open partial cystectomy. For most non-muscle invasive bladder cancers, even surgical treatment requires intravesical instillation to reduce and completely remove cancer cells.
[0003] At present, the existing intravesical instillation devices and methods are prone to continuous dilution after the chemotherapy drugs are injected. Therefore, when the patient urinates normally, the drugs are continuously diluted with the urine in the bladder. As the urine is excreted, the drug is severely diluted and the effective therapeutic concentration cannot be guaranteed, thereby significantly reducing the chemotherapy effect. Summary of the invention
[0004] In view of the deficiencies of the prior art, the present invention provides an intravesical instillation device and method, which solves the problems mentioned in the above background technology, such as the inability of the prior art to ensure the therapeutic concentration of the drug stored in the bladder.
[0005] To achieve the above objectives, the present invention is implemented through the following technical solutions: an intra-bladder infusion device and method, comprising a wrapping tube, a first air bag is installed on the outer surface of the wrapping tube, an infusion tube is installed inside the wrapping tube, an extraction tube is installed on the side end of the infusion tube, a second air bag is installed on the outer surface of the extraction tube, a three-way valve tube is installed on the side end of the infusion tube, a syringe is installed on the upper end of the three-way valve tube, a thermostat is installed on the side end of the three-way valve tube away from the infusion tube, two cold and hot water tanks are installed on the side end of the thermostat away from the three-way valve tube, a storage box is installed on the side end of the extraction tube, a second fixed base is sleeved on the outer surface of the storage box, a first fixed base is installed on the upper end of the second fixed base, the outer surface of each of the cold and hot water tanks is sleeved with the same first fixed base, two first signal receivers are installed on the upper end of the first fixed base, and the side ends of each of the first signal receiver and the second signal receiver are installed with transmission wires, and the side ends of each of the transmission wires are installed with the same control terminal.
[0006] Optionally, a reserved hole is opened inside the wrapping tube, and a first air supply pipe is installed at the side end of the first airbag, and the first air supply pipe is installed on the outer surface of the wrapping tube.
[0007] Optionally, the perfusion tube and the extraction tube are both installed inside the wrapping tube through reserved holes, and the same second air pipe is installed on the outer surface of the perfusion tube and the extraction tube, and the side end of the second air pipe is connected to the inside of the second airbag.
[0008] Optionally, a pressure detector is installed on the outer surface of the perfusion tube, and a one-way valve is installed inside the side end of the extraction tube away from the storage box.
[0009] Optionally, a rotary switch is installed at the side end of the three-way valve tube, and a first connecting hose is installed at the side end of the three-way valve tube. The three-way valve tube is connected to a thermostat by cooperating with the first connecting hose, and an adjusting knob is rotatably installed at the upper end of the thermostat.
[0010] Optionally, a second connecting hose is installed on the side end of each of the hot and cold water tanks, and each of the hot and cold water tanks is connected to a thermostat via the second connecting hose. Two first controllers are installed inside the first fixed base, and two first pushers are installed inside the first fixed base.
[0011] Optionally, each of the first pushers is connected to the inside of the cold and hot water tank, and each of the first controllers is connected to two first signal receivers above the first fixed base.
[0012] Optionally, a second controller is installed inside the second fixed base, a second pusher is installed inside the second fixed base, and a side end of the second pusher is connected to the inside of the storage box.
[0013] Optionally, the second controller is connected to the second pusher and is also connected to the second signal receiver. Both the second controller and the first controller can be connected and controlled with the control terminal through the second signal receiver, the first signal receiver and the transmission wire.
[0014] A method for using an intravesical instillation device, the specific steps are as follows:
[0015] Step 1: After the patient empties his urine, he lies on his back on a special magnetically controlled treatment bed, and then lidocaine is injected into the urethra for surface anesthesia. The user then picks up the wrapped tube and inserts it into the patient's urethra along the side end of the internal extraction tube with a one-way valve installed on one side;
[0016] Step 2: Connect an air pump to the side end of the first air delivery tube installed along the outer surface of the wrapping tube, and then start the air pump to inject gas into the first air delivery tube. As the injected gas increases, the outer surface connected to the side end of the first air delivery tube will be lifted up, and the first air bag will be lifted up to seal the urethra;
[0017] Step 3: The user turns the adjustment knob. According to the scale lines engraved on the thermostat, after turning the adjustment knob to a suitable temperature, the user transmits a signal to the first signal receiver through the control terminal in conjunction with the transmission wire. After receiving the signal, the first signal receiver will send it to the first controller. The first controller starts the first pusher, thereby pushing the internal water sources of the two cold and hot water tanks so that the second connecting hose flows into the thermostat for mixed temperature adjustment. The thermostat is provided with a thermal element, which uses the characteristics of the temperature sensing element to push the valve core in the valve body to move, thereby blocking or opening the cold and hot water inlets, and then according to the rotation angle of the adjustment knob, the opening size is adjusted to adjust the ratio of cold and hot water in the thermostat;
[0018] Step 4: The user turns on the thermostat, and the water source after temperature adjustment inside the thermostat flows into the three-way valve tube through the first connecting hose, and then passes through the three-way valve tube and the upper irrigation tube through the wrapping tube and then through the urethra into the bladder. Then the user turns off the thermostat, and then turns the switch at the side end of the three-way valve tube to block one side of the thermostat and connect the side with the irrigation tube to the upper opening of the three-way valve tube;
[0019] Step 5: After the connection is completed, the user connects a syringe to the opening above the three-way valve tube. The syringe is filled with a drug-loaded robot suspension (reverse gel chemotherapy drugs and magnetically controlled robots are prepared. The drug has a polymer with temperature-sensitive reverse gel properties as a carrier material. When the temperature is lower than body temperature, the sample exists in the form of a sol. After being injected into the body, when the temperature at the injection site rises to body temperature, the sol is transformed into a semi-solid gel. As the carrier material slowly dissolves, the drug is released from the gel at a slow rate. The sustained release time of the drug can last for weeks to months). The push rod in the syringe is lifted upward to allow ten milliliters of air to flow into the bottom of the syringe, and then it is installed above the three-way valve tube. Subsequently, the drug is injected through the three-way valve tube, the perfusion tube and other parts. During the injection process, the air drawn in will generate air between the previously injected distilled water and the drug solution, thereby separating the suspension and preventing it from being fused in advance in the pipeline, thereby ensuring that the drug is not released in the urethra, thereby avoiding chemical damage to the urethra.
[0020] Step 6: After the drug enters the bladder, the user turns the rotary switch again to connect one side of the infusion tube with one side of the thermostat, and then continues to deliver distilled water to the bladder. Then, the liquid inside the bladder gradually increases. The user installs an air pump on one side of the second air delivery tube to expand the second air bag in the same way, so that the side ends of the one-way valve and the side ends of the extraction tube can float above the liquid. Then, the pressure detector installed on the outer surface of the infusion tube detects and feeds back the changes in the internal pressure of the bladder to the control terminal in real time, so that the adjustment can be more intuitive.
[0021] Step 6, when the liquid inside the bladder gradually increases, the user can operate the control terminal to cooperate with the transmission wire to transmit a signal to the second signal receiver, thereby controlling the second controller to start the second pusher. The second pusher will pull the side rod back when it is started, so as to cooperate with the storage box and the extraction tube to extract the internal liquid and air and maintain the internal pressure of the bladder at 40. Then, a one-way valve is provided at the side end of the extraction tube to prevent the residual liquid in the extraction tube from returning. Then, during the treatment process, as urine is produced, the internal pressure of the bladder will also change. It is necessary to extract the liquid in the same way so that the patient can tolerate it and the bladder is always full of liquid during the treatment.
[0022] Step 7: After the drug enters the bladder, it quickly reaches the same temperature as the liquid in the bladder. The reverse gel drug-carrying system is converted into a liquid state and begins to release the drug outward with the robot as the center. Then, under the control of the magnetic control device of the special treatment bed, the magnetic control robot performs a circular spiral motion in the liquid along the bladder wall over and over again. The trajectory covers the entire bladder wall (including the top and bottom), so that the surface of the bladder wall continuously maintains the therapeutic drug concentration. Then, because the temperature of the bladder wall is 37 degrees, the drug will form a layer of gel on the surface of the bladder wall. As time goes by, the gel layer gradually thickens until the temperature of the bladder perfusion fluid rises to 37 degrees. At this time, the treatment bed stops working and the robot in the bladder stops releasing drugs.
[0023] Step 8: After the treatment, remove the device and ask the patient to urinate. The drug gel will be evenly retained on the inner wall of the bladder (the component of the drug gel, chitosan, has a positive charge, and the surface of the bladder mucosa has a negative charge, which promotes adhesion) and continue to work.
[0024] The present invention provides an intravesical instillation device and method, which have the following beneficial effects:
[0025] 1. The intravesical infusion device and method are designed to cooperate with each other through the syringe, the three-way valve tube and the infusion tube, the wrapping tube, the extraction tube and the second fixed base, the thermostat, the control terminal and other parts, so that the device can evenly cover the drug with the bladder wall for attachment when in use, thereby improving the adhesion of the drug to the bladder wall, thereby improving the chemotherapy effect.
[0026] 2. The intravesical instillation device and method cooperate with each other through the instillation tube, extraction tube, three-way valve tube, syringe and other parts, so that when the device is used, it can reduce the diffusion of drugs in the urethra, thereby reducing chemical damage to the urethra.
[0027] 3. The intra-bladder infusion device and method cooperate with the thermostat by adjusting the knob to adjust the temperature of the water source delivered to the bladder, so that the temperature of the medicine inside the bladder is more convenient and quick when the device is used, thereby improving the practicality of the device.
[0028] 4. The intravesical instillation device and method cooperate with each other through the pressure detector, the control terminal, the transmission wire and the second signal receiver, so that the device can detect the internal pressure of the bladder in real time when in use, thereby facilitating internal adjustments and ensuring the patient's comfort during treatment.
[0029] 5. The intravesical instillation device and method mixes the drugs in proportion in advance outside the bladder so that the sample exists in the form of a sol, thereby cooperating with a syringe and other parts to achieve rapid drug delivery. At the same time, as the drug is released, the drug sustained-release time can be slowed down, thereby improving the efficiency of drug use. BRIEF DESCRIPTION OF THE DRAWINGS
[0030] Figure 1 It is a schematic diagram of the wrapping tube structure in the intravesical instillation device and method;
[0031] Figure 2 It is a schematic diagram of the structure of the first fixed base in the intravesical instillation device and method;
[0032] Figure 3 It is a schematic structural diagram of the second fixed base in the intravesical instillation device and method;
[0033] Figure 4 It is a schematic diagram of the structure of the first air bag in the intravesical instillation device and method;
[0034] Figure 5 It is a schematic diagram of the control terminal structure in the intravesical instillation device and method.
[0035] In the figure: 1. wrapping tube; 11. reserved hole; 12. first air bag; 13. first air pipe; 14. perfusion pipe; 15. extraction pipe; 16. one-way valve; 17. second air bag; 18. second air pipe; 19. pressure detector; 2. three-way valve tube; 21. rotary switch; 22. syringe; 23. first connecting hose; 24. thermostat; 25. adjustment knob; 26. first fixed base; 27. hot and cold water tank; 28. first pusher; 29. second connecting hose; 3. first controller; 31. first signal receiver; 32. second fixed base; 33. storage box; 34. second pusher; 35. second controller; 36. second signal receiver; 37. transmission wire; 38. control terminal. DETAILED DESCRIPTION
[0036] The technical solutions in the embodiments of the present invention will be described clearly and completely below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments.
[0037] In the description of the present invention, unless otherwise specified, "plurality" means two or more than two; the orientations or positional relationships indicated by the terms "upper", "lower", "left", "right", "inner", "outer", "front end", "rear end", "head", "tail", etc. are based on the orientations or positional relationships shown in the drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operate in a specific orientation, and therefore cannot be understood as limiting the present invention. In addition, the terms "first", "second", "third", etc. are only used for descriptive purposes and cannot be understood as indicating or implying relative importance.
[0038] In the description of the present invention, it should be noted that, unless otherwise clearly specified and limited, the terms "connected" and "connection" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.
[0039] See also Figures 1 to 5The present invention provides a technical solution: an intravesical instillation device and method, comprising a wrapping tube 1, a first air bag 12 is installed on the outer surface of the wrapping tube 1, an instillation tube 14 is installed inside the wrapping tube 1, an extraction tube 15 is installed on the side end of the instillation tube 14, a second air bag 17 is installed on the outer surface of the extraction tube 15, a three-way valve tube 2 is installed on the side end of the instillation tube 14, a syringe 22 is installed on the upper end of the three-way valve tube 2, a thermostat 24 is installed on the side end of the three-way valve tube 2 away from the instillation tube 14, and a thermostat 24 is installed on the side end of the thermostat 24 away from the side of the three-way valve tube 2. Two hot and cold water tanks 27 are installed, and a storage box 33 is installed on the side end of the extraction pipe 15. The outer surface of the storage box 33 is sleeved with a second fixed base 32, and the upper end of the second fixed base 32 is installed with a first fixed base 26. The outer surface of each hot and cold water tank 27 is sleeved with the same first fixed base 26, and the upper end of the first fixed base 26 is installed with two first signal receivers 31. The side ends of each first signal receiver 31 and the second signal receiver 36 are installed with a transmission wire 37, and the side end of each transmission wire 37 is installed with the same control terminal 38.
[0040] In this embodiment, Figure 1 and Figure 4 As shown, a reserved hole 11 is opened inside the wrapping tube 1, and a first air pipe 13 is installed on the side end of the first air bag 12, and the first air pipe 13 is installed on the outer surface of the wrapping tube 1; this structure can cooperate with the subsequent perfusion tube 14, extraction tube 15 and other parts through the reserved hole 11 opened inside the wrapping tube 1, so as to fill and occupy the reserved hole 11, which is convenient for subsequent use.
[0041] In this embodiment, Figure 1 and Figure 3 As shown, the perfusion tube 14 and the extraction tube 15 are both installed inside the wrapping tube 1 through the reserved hole 11, and the same second air pipe 18 is installed on the outer surface of the perfusion tube 14 and the extraction tube 15, and the side end of the second air pipe 18 is connected to the inside of the second air bag 17; this structure can facilitate the air supply to the inside of the second air bag 17 through the second air pipe 18, thereby facilitating subsequent use.
[0042] In this embodiment, Figure 1 and Figure 3 As shown, a pressure detector 19 is installed on the outer surface of the infusion tube 14, and a one-way valve 16 is installed inside the side end of the extraction tube 15 away from the storage box 33. This structure can detect the pressure inside the bladder in real time through the pressure detector 19, so as to cooperate with the subsequent storage box 33 and other parts to adjust the pressure inside the bladder, thereby improving the patient's comfort.
[0043] In this embodiment, Figure 1 and Figure 2As shown, a rotary switch 21 is installed at the side end of the three-way valve tube 2, and a first connecting hose 23 is installed at the side end of the three-way valve tube 2. The three-way valve tube 2 is connected to the thermostat 24 by cooperating with the first connecting hose 23, and an adjusting knob 25 is rotatably installed at the upper end of the thermostat 24; this structure can connect the pipeline in different directions by cooperating with the rotary switch 21 on the three-way valve tube 2, thereby improving the convenience of the device.
[0044] In this embodiment, Figure 1 and Figure 2 As shown, a second connecting hose 29 is installed at the side end of each cold and hot water tank 27, and each cold and hot water tank 27 is connected to the thermostat 24 through the second connecting hose 29. Two first controllers 3 are installed inside the first fixed base 26, and two first pushers 28 are installed inside the first fixed base 26; this structure can transmit signals to the first controller 3 through the first signal receiver 31, thereby controlling the first pusher 28 to extend and retract, thereby controlling the water source inside the cold and hot water tank 27 to transport.
[0045] In this embodiment, Figure 1 and Figure 2 As shown, each first pusher 28 is connected to the inside of the hot and cold water tank 27, and each first controller 3 is connected to the two first signal receivers 31 above the first fixed base 26; this structure can be conveniently operated through the first controller 3 and the first signal receiver 31 in conjunction with the subsequent transmission wires 37 and the control terminal 38.
[0046] In this embodiment, Figure 1 and Figure 3 As shown, a second controller 35 is installed inside the second fixed base 32, and a second pusher 34 is installed inside the second fixed base 32. The side end of the second pusher 34 is connected to the inside of the storage box 33. This structure enables the second controller 35 to control the use of the second pusher 34, thereby cooperating with the storage box 33 and the extraction tube 15 to adjust the internal air pressure of the bladder.
[0047] In this embodiment, Figure 1 and Figure 5 As shown, the second controller 35 is connected to the second pusher 34 and is connected to the second signal receiver 36 at the same time. The second controller 35 and the first controller 3 can be connected and controlled by the control terminal 38 through the second signal receiver 36, the first signal receiver 31 and the transmission wire 37; this structure can cooperate with the pressure detector 19 and other parts through the control terminal 38 to perform real-time operation control of the device, thereby improving the accuracy of treatment and thus improving the success rate of treatment.
[0048] A method for using an intravesical instillation device, the specific steps are as follows:
[0049] Step 1: After the patient empties his urine, he lies on his back on a special magnetically controlled treatment bed, and then lidocaine is injected into the urethra for surface anesthesia. Then the user picks up the wrapping tube 1 and inserts it into the patient's urethra along the side end of the internal extraction tube 15 equipped with a one-way valve 16;
[0050] Step 2: The first air delivery tube 13 installed along the outer surface of the wrapping tube 1 is connected to an air pump at its side end, and then the air pump is started to inject gas into the first air delivery tube 13. As the injected gas increases, the outer surface connected to the side end of the first air delivery tube 13 is lifted up, and the first air bag 12 is lifted up, thereby sealing the urethra;
[0051] Step 3: The user turns the adjusting knob 25, and after turning the adjusting knob 25 to a suitable temperature according to the scale lines engraved on the top of the thermostat 24, the user transmits a signal to the first signal receiver 31 through the control terminal 38 in conjunction with the transmission wire 37. After receiving the signal, the first signal receiver 31 will send it to the first controller 3. The first controller 3 starts the first pusher 28, thereby pushing the internal water sources of the two cold and hot water tanks 27 and the second connecting hose 29 to flow into the thermostat 24 for mixed temperature adjustment. The thermostat 24 is provided with a thermal element, and the characteristics of the temperature sensing element are used to push the valve core in the valve body to move, thereby blocking or opening the cold and hot water inlets, and then according to the rotation angle of the adjusting knob 25, the opening size is adjusted to adjust the cold and hot water ratio in the thermostat 24;
[0052] Step 4: The user turns on the thermostat 24, and the water source after temperature adjustment inside the thermostat 24 flows into the three-way valve tube 2 through the first connecting hose 23, and then passes through the three-way valve tube 2 and the irrigation tube 14 through the wrapping tube 1 and then through the urethra into the bladder. Then the user turns off the thermostat 24, and then turns the rotation switch 21 at the side end of the three-way valve tube 2 to block one side of the thermostat 24 and connect the side with the irrigation tube 14 to the upper opening of the three-way valve tube 2;
[0053] Step 5: After the connection is completed, the user connects the syringe 22 to the opening above the three-way valve tube 2. The syringe 22 is filled with a drug-loaded robot suspension (reverse gel chemotherapy drugs and magnetically controlled robots are prepared. The drug has a polymer with temperature-sensitive reverse gel properties as a carrier material. When the temperature is lower than body temperature, the sample exists in the form of sol. After being injected into the body, when the temperature at the injection site rises to body temperature, the sol is transformed into a semi-solid gel. As the carrier material slowly dissolves, the drug is released from the gel at a slow rate. The sustained release time of the drug can last for several weeks to several months). The push rod in the syringe 22 is lifted upward to allow ten milliliters of air to flow into the bottom of the syringe 22, and then it is installed above the three-way valve tube 2. Subsequently, the drug is injected through the three-way valve tube 2, the perfusion tube 14 and other parts. During the injection process, the air drawn in will generate air between the previously injected distilled water and the drug solution, thereby separating the suspension and preventing it from being fused in the pipeline in advance, thereby ensuring that the drug is not released in the urethra, thereby avoiding chemical damage to the urethra.
[0054] Step 6: After the drug enters the bladder, the user turns the rotary switch 21 again to connect one side of the infusion tube 14 with one side of the thermostat 24, and then continues to deliver distilled water into the bladder. Then, the liquid inside the bladder gradually increases. The user installs an air pump on one side of the second air delivery tube 18 to expand the second air bag 17 in the same way, so that the side ends of the one-way valve 16 and the side ends of the extraction tube 15 can float above the liquid. Then, the pressure detector 19 installed on the outer surface of the infusion tube 14 detects and feeds back the changes in the internal pressure of the bladder to the control terminal 38 in real time, so that the adjustment can be more intuitive.
[0055] Step 6, when the liquid inside the bladder gradually increases, the user can operate the control terminal 38 to cooperate with the transmission wire 37 to transmit a signal to the second signal receiver 36, so as to control the second controller 35 to start the second pusher 34. The second pusher 34 will pull the side rod to recover, so as to cooperate with the storage box 33 and the extraction tube 15 to extract the internal liquid and air, and maintain the internal pressure of the bladder at 40. Then, a one-way valve 16 is provided at the side end of the extraction tube 15 to prevent the residual liquid in the extraction tube 15 from returning. Then, during the treatment process, as urine is produced, the internal pressure of the bladder will also change, so it is necessary to extract the liquid in the same way so that the patient can tolerate it and the bladder is always full of liquid during the treatment.
[0056] Step 7: After the drug enters the bladder, it quickly reaches the same temperature as the liquid in the bladder. The reverse gel drug-carrying system is converted into a liquid state and begins to release the drug outward with the robot as the center. Then, under the control of the magnetic control device of the special treatment bed, the magnetic control robot performs a circular spiral motion in the liquid along the bladder wall over and over again. The trajectory covers the entire bladder wall (including the top and bottom), so that the surface of the bladder wall continuously maintains the therapeutic drug concentration. Then, because the temperature of the bladder wall is 37 degrees, the drug will form a layer of gel on the surface of the bladder wall. As time goes by, the gel layer gradually thickens until the temperature of the bladder perfusion fluid rises to 37 degrees. At this time, the treatment bed stops working and the robot in the bladder stops releasing drugs.
[0057] Step 8: After the treatment, remove the device and ask the patient to urinate. The drug gel will be evenly retained on the inner wall of the bladder (the component of the drug gel, chitosan, has a positive charge, and the surface of the bladder mucosa has a negative charge, which promotes adhesion) and continue to work.
[0058] In summary, the bladder infusion device and method, when used, the user picks up the wrapping tube 1, sets the first air bag 12 on the outer surface of the wrapping tube 1, then installs the first air supply pipe 13 on the side end of the first air bag 12, then installs the infusion tube 14 in the reserved hole 11 opened inside the wrapping tube 1, then installs the extraction tube 15 in the reserved hole 11 on the side end of the infusion tube 14, then installs the second air bag 17 on the outer surface of the infusion tube 14 and the extraction tube 15, then installs the one-way valve 16 on the side end of the extraction tube 15, then installs the second air supply pipe 18 on the side end of the second air bag 17, and then Pick up the three-way valve tube 2, install the rotary switch 21 on the side end of the three-way valve tube 2, then install the first connecting hose 23 on one side of the three-way valve tube 2, install the thermostat 24 on the side end of the first connecting hose 23, install the adjusting knob 25 above the thermostat 24, then install the syringe 22 above the three-way valve tube 2, dock the assembled three-way valve tube 2 with the perfusion tube 14 along the opening on the side away from the first connecting hose 23, then the user picks up the first fixed base 26, installs two hot and cold water tanks 27 inside the first fixed base 26, and then installs the syringe 22 on the first fixed base 2 6, two first controllers 3 are installed on the side ends, two first pushers 28 are installed on the inner wall of the first fixed base 26 behind the two first controllers 3, and then two first signal receivers 31 are installed on the first fixed base 26 to connect with the first controllers 3 respectively, and then the two first pushers 28 are extended to the inside of the cold and hot water tank 27, and then the second connecting hose 29 is installed on the other side of the cold and hot water tank 27, and then the cold and hot water tank 27 and other parts are connected to the thermostat 24 through the second connecting hose 29, and then the user picks up the second fixed base 32, and then A storage box 33 is installed inside the second fixed base 32, and then a second controller 35 is installed on the side end of the second fixed base 32, and then a second pusher 34 is installed on the inner wall of the second fixed base 32, and then a second signal receiver 36 is installed above the second fixed base 32, and the side end of the second pusher 34 is extended into the storage box 33, and then the storage box 33 and other parts are installed to the side end position of the extraction tube 15, and then the transmission wire 37 is connected to the side ends of the second signal receiver 36 and the first signal receiver 31, and then the same control terminal 38 is installed on the side end of the transmission wire 37.
[0059] The above description is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes according to the technical scheme and inventive concept of the present invention within the technical scope disclosed by the present invention, which should be covered by the protection scope of the present invention.
Claims
1. An intravesical instillation device, comprising a wrapping tube (1), characterized in that: The outer surface of the wrapping tube (1) is provided with a first air bag (12), the interior of the wrapping tube (1) is provided with an infusion tube (14), the side end of the infusion tube (14) is provided with an extraction tube (15), the outer surface of the extraction tube (15) is provided with a second air bag (17), the side end of the infusion tube (14) is provided with a three-way valve tube (2), the upper end of the three-way valve tube (2) is provided with a syringe (22), the side end of the three-way valve tube (2) away from the infusion tube (14) is provided with a thermostat (24), the side end of the thermostat (24) away from the three-way valve tube (2) is provided with two hot and cold water tanks (27), A storage box (33) is installed at the side end of the extraction tube (15), and a second fixed base (32) is sleeved on the outer surface of the storage box (33), and a first fixed base (26) is installed on the upper end of the second fixed base (32). The outer surface of each of the hot and cold water tanks (27) is sleeved on the same first fixed base (26), and two first signal receivers (31) are installed on the upper end of the first fixed base (26). A transmission wire (37) is installed on the side end of each of the first signal receivers (31) and the second signal receiver (36), and a same control terminal (38) is installed on the side end of each of the transmission wires (37).
2. The intravesical instillation device according to claim 1, characterized in that: A reserved hole (11) is provided inside the wrapping tube (1), a first air supply pipe (13) is installed at the side end of the first air bag (12), and the first air supply pipe (13) is installed on the outer surface of the wrapping tube (1).
3. The intravesical instillation device according to claim 2, characterized in that: The perfusion tube (14) and the extraction tube (15) are both installed inside the wrapping tube (1) through the reserved hole (11); the outer surfaces of the perfusion tube (14) and the extraction tube (15) are installed with the same second air supply tube (18); the side end of the second air supply tube (18) is connected to the inside of the second air bag (17).
4. The intravesical instillation device according to claim 1, characterized in that: A pressure detector (19) is installed on the outer surface of the perfusion pipe (14), and a one-way valve (16) is installed inside the side end of the extraction pipe (15) away from the storage box (33).
5. The intravesical instillation device according to claim 1, characterized in that: A rotary switch (21) is installed at the side end of the three-way valve tube (2), and a first connecting hose (23) is installed at the side end of the three-way valve tube (2). The three-way valve tube (2) is connected to a thermostat (24) by cooperating with the first connecting hose (23), and an adjusting knob (25) is rotatably installed at the upper end of the thermostat (24).
6. The intravesical instillation device according to claim 1, characterized in that: A second connecting hose (29) is installed at the side end of each of the cold and hot water tanks (27), and each of the cold and hot water tanks (27) is connected to the thermostat (24) via the second connecting hose (29). Two first controllers (3) are installed inside the first fixed base (26), and two first pushers (28) are installed inside the first fixed base (26).
7. The intravesical instillation device according to claim 6, characterized in that: Each of the first pushers (28) is connected to the inside of the hot and cold water tank (27), and each of the first controllers (3) is connected to two first signal receivers (31) above the first fixed base (26).
8. The intravesical instillation device according to claim 7, characterized in that: A second controller (35) is installed inside the second fixed base (32), and a second pusher (34) is installed inside the second fixed base (32), and a side end of the second pusher (34) is connected to the inside of the storage box (33).
9. The intravesical instillation device according to claim 8, characterized in that: The second controller (35) is connected to the second pusher (34) and is also connected to the second signal receiver (36). The second controller (35) and the first controller (3) can be connected and controlled by the control terminal (38) through the second signal receiver (36), the first signal receiver (31) and the transmission wire (37).
10. A method for using an intravesical instillation device according to any one of claims 1 to 9, characterized in that: The specific steps are as follows: Step 1: After the patient empties his urine, he lies supinely on a special magnetically controlled treatment bed, and then lidocaine is injected into the urethra for surface anesthesia. Then the user picks up the wrapping tube (1) and inserts it into the patient's urethra along the side end of the internal extraction tube (15) equipped with a one-way valve (16); Step 2: A first air delivery tube (13) is installed along the outer surface of the wrapping tube (1), and an air pump is connected to the side end thereof. Then, the air pump is started to inject gas into the first air delivery tube (13). As the injected gas increases, the outer surface connected to the side end of the first air delivery tube (13) is lifted up, and the first air bag (12) is lifted up, thereby sealing the urethra; Step 3: The user turns the adjusting knob (25) to a suitable temperature according to the scale lines engraved on the top of the thermostat (24). The user then transmits a signal to the first signal receiver (31) through the control terminal (38) in conjunction with the transmission wire (37). After receiving the signal, the first signal receiver (31) sends the signal to the first controller (3). The first controller (3) activates the first pusher (28), thereby pushing the internal water sources of the two cold and hot water tanks (27) and the second connecting hose (29) to flow into the thermostat (24) for mixed temperature adjustment. The thermostat (24) is provided with a thermal element, which uses the characteristics of the temperature sensing element to push the valve core in the valve body to move, thereby blocking or opening the cold and hot water inlets. Then, according to the rotation angle of the adjusting knob (25), the opening size is adjusted to adjust the cold and hot water ratio in the thermostat (24); Step 4: The user turns on the thermostat (24), and the water source after temperature adjustment inside the thermostat (24) flows into the three-way valve tube (2) through the first connecting hose (23), and then passes through the three-way valve tube (2) and the irrigation tube (14) through the wrapping tube (1) and thus through the urethra into the bladder. Then the user turns off the thermostat (24), and then turns the rotary switch (21) at the side end of the three-way valve tube (2) to block one side of the thermostat (24) and connect the side with the irrigation tube (14) to the upper opening of the three-way valve tube (2); Step 5: After the connection is completed, the user connects the syringe (22) to the opening above the three-way valve tube (2). The syringe (22) contains a drug-loaded robot suspension, which is prepared by reverse gel chemotherapy drugs and magnetically controlled robots. The drug has a polymer with temperature-sensitive reverse gel properties as a carrier material. When the temperature is lower than body temperature, the sample exists in the form of sol. After being injected into the body, when the temperature at the injection site rises to body temperature, the sol is transformed into a semi-solid gel. As the carrier material slowly dissolves, the drug is released from the gel at a slow rate. The sustained release time of the drug can last for several weeks to several months. The push rod in the syringe (22) is lifted upward to allow ten milliliters of air to flow into the lower part of the syringe (22), and then the syringe is installed above the three-way valve tube (2). The drug is then injected through the three-way valve tube (2), the perfusion tube (14) and other parts. During the injection process, the air drawn in will generate air between the previously injected distilled water and the drug solution, thereby separating the suspension and preventing it from being fused in advance in the pipeline, thereby ensuring that the drug is not released in the urethra, thereby avoiding chemical damage to the urethra; Step 6: After the drug enters the bladder, the user turns the rotary switch (21) again to connect one side of the infusion tube (14) with one side of the thermostat (24), and then continues to deliver distilled water to the bladder. Then, the liquid inside the bladder gradually increases. The user installs an air pump on one side of the second air delivery tube (18) to expand the second air bag (17) in the same way, so that the side end of the one-way valve (16) and the side end of the extraction tube (15) can float above the liquid. Then, the pressure detector (19) installed on the outer surface of the infusion tube (14) detects and feeds back the change of the internal pressure of the bladder to the control terminal (38) in real time, so that the adjustment can be more intuitive. Step 6, when the liquid inside the bladder gradually increases, the user can operate the control terminal (38) in conjunction with the transmission wire (37) to transmit a signal to the second signal receiver (36), thereby controlling the second controller (35) to start the second pusher (34). The second pusher (34) will pull the side rod back when it is started, thereby cooperating with the storage box (33) and the extraction tube (15) to extract the internal liquid and air, and maintain the internal pressure of the bladder at 40. Then, a one-way valve (16) is provided at the side end of the extraction tube (15) to prevent the residual liquid in the extraction tube (15) from returning. Then, during the treatment process, as urine is produced, the internal pressure of the bladder will also change, and it is necessary to extract the liquid in the same way so that the patient can tolerate it and the bladder is always full of liquid during the treatment. Step 7: After the drug enters the bladder, it quickly reaches the same temperature as the liquid in the bladder. The reverse gel drug-carrying system is converted into a liquid state and begins to release the drug outward with the robot as the center. Then, under the control of the magnetic control device of the special treatment bed, the magnetic control robot performs a circular spiral motion in the liquid along the bladder wall over and over again. The trajectory covers the entire bladder wall, so that the surface of the bladder wall continuously maintains the therapeutic drug concentration. Then, because the temperature of the bladder wall is 37 degrees, the drug will form a layer of gel on the surface of the bladder wall. As time goes by, the gel layer gradually thickens until the temperature of the bladder perfusion liquid rises to 37 degrees. At this time, the treatment bed stops working and the robot in the bladder stops releasing drugs. Step 8: After the treatment, remove the device and ask the patient to urinate. The drug gel will be evenly retained on the inner wall of the bladder and continue to work. The component of the drug gel, chitosan, has a positive charge, and the surface of the bladder mucosa has a negative charge, which promotes adhesion.