Musk-containing traditional Chinese medicine pellet and preparation method thereof

Abstract

The invention discloses a musk-containing traditional Chinese medicine pellet and a preparation method thereof. The musk-containing traditional Chinese medicine pellet is prepared from the following components: a traditional Chinese medicine composition, a diluent and an adhesive, the traditional Chinese medicine pellet prepared by the preparation method disclosed by the invention is relatively small in particle size and large in specific surface area, and dissolution and absorption of the musk and other medicine components in a body are facilitated, so that the bioavailability is improved, and the efficacy of the prepared traditional Chinese medicine pellet can be further improved.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, in particular to a musk-containing traditional Chinese medicine micro-pill and a preparation method thereof. Background Art

[0002] Musk mainly comes from the secretions of the scent sac under the abdomen of male musk deer (such as forest musk deer, red musk deer or wild musk deer). When these animals encounter threats or are in estrus, they will secrete a substance with a strong smell from the scent sac. This secreted substance is musk.

[0003] Fresh musk that has just been secreted is dark brown, solid and granular, with a strong pungent smell. After the musk is dried, its aroma becomes soft and lasting, making it an extremely precious spice and medicinal material that can be used in a variety of traditional Chinese medicines.

[0004] Musk is an extremely precious medicinal material. It has many functions such as invigorating the mind, promoting blood circulation and menstruation, reducing swelling and relieving pain. Musk is often used as an important adjuvant drug in the treatment of diseases such as stroke, epilepsy, and sudden abdominal pain. In addition, musk also has antiseptic and antibacterial effects, and can protect medicinal materials from insect infestation and mildew.

[0005] However, the effect of musk when used directly is relatively general, and it usually needs to be used in combination with other Chinese medicinal ingredients. Traditional Chinese medicine decoction is not suitable for the use of musk. Therefore, in order to more conveniently use multiple ingredients in combination, Chinese medicine microcapsules were born. The emergence of Chinese medicine microcapsules not only improves the stability and bioavailability of Chinese medicine preparations, but also greatly improves the problems of inconvenience in taking and poor taste of traditional Chinese medicine preparations. Summary of the invention

[0006] The invention aims to provide a musk-containing Chinese medicine pellet to solve the deficiencies in the prior art.

[0007] The technical solution adopted by the present invention is as follows:

[0008] A musk-containing Chinese medicine pellet, comprising the following components by weight: 45-50 parts of a Chinese medicine composition, 30-35 parts of a diluent, and 10-12 parts of a binder;

[0009] The traditional Chinese medicine composition is prepared from astragalus, musk, wolfberry, angelica, angelica dahurica and lead as raw materials.

[0010] As a further technical solution: the method for preparing the Chinese medicine composition comprises the following steps:

[0011] First, weigh out by weight: 10-15 parts of astragalus, 0.3-0.5 parts of musk, 2-8 parts of wolfberry, 3-6 parts of angelica, 2-4 parts of angelica, and 0.8-1.5 parts of lead;

[0012] Firstly, astragalus and water are mixed in a mass ratio of 1:5, and then pulped to obtain astragalus slurry;

[0013] Adding ethanol solution to the astragalus slurry, stirring at a speed of 500r / min for 10min, and then performing reflux extraction for 4 hours. After the reflux extraction is completed, adding it to a centrifuge for high-speed centrifugation. After high-speed centrifugation, standing for 30min, and then filtering to remove the filter residue to obtain a filtrate, recycling the filter residue for 3 times using the same method, and then combining the multiple filtrates, and spray drying the combined filtrates to obtain an astragalus extract;

[0014] Drying the wolfberries to reduce their moisture content to less than 5%, and then crushing them to obtain wolfberry powder;

[0015] Wherein, drying is carried out by microwave drying;

[0016] The power of microwave drying was 350W;

[0017] Add angelica and angelica dahurica to the mixer in sequence, mix for 10 minutes, then add water 12 times the weight of angelica, continue mixing for 10 minutes, then transfer to a frying furnace, heat to 100°C, keep warm for 10 minutes, then fry slowly over low heat, filter after cooling, remove solid residue, and obtain a decoction;

[0018] The decoction is spray-dried to obtain a mixed extract;

[0019] The priming material is: ginger juice;

[0020] Astragalus extract, wolfberry powder, mixed extract, musk and ginger juice are mixed together, stirred evenly, and then dried to obtain a traditional Chinese medicine composition;

[0021] The drying temperature was 65°C and the drying time was 4 hours.

[0022] As a further technical solution: the volume ratio of the astragalus slurry and the ethanol solution is 1:2;

[0023] The mass fraction of the ethanol solution is 70%.

[0024] As a further technical solution: the centrifugal speed of the high-speed centrifugal treatment is 8000r / min;

[0025] Among them, the high-speed centrifugation treatment time is 20 minutes.

[0026] As a further technical solution: the slow frying time is 2-3 hours.

[0027] As a further technical solution: the ginger juice preparation method is:

[0028] Peel the fresh ginger;

[0029] Slice the peeled ginger to obtain ginger slices;

[0030] Soak the ginger slices in water and then take them out;

[0031] The soaked ginger slices are added to a juicer, and water 10% of the weight of the ginger slices is added, and the ginger juice is obtained by squeezing.

[0032] As a further technical solution: the soaking is:

[0033] Mix ginger slices and water in a mass ratio of 1:15, adjust the temperature to 40°C, soak for 1 hour, and then take out.

[0034] As a further technical solution: the diluent is microcrystalline cellulose.

[0035] As a further technical solution: the adhesive is starch;

[0036] The starch is corn starch.

[0037] A method for preparing musk-containing Chinese medicine pellets comprises the following steps:

[0038] Weigh each component according to its weight;

[0039] Add each component to a universal grinder in turn, mix and grind to obtain a mixed powder;

[0040] Add pure water to the mixed powder, continue mixing, and then extrude and granulate through an extruder at 45 rpm. The particles are spheronized at high speed for 40 min at a speed of 1200 rpm, a blast frequency of 15 Hz, a peristaltic pump speed of 12 rpm, and an atomization pressure of 0.78 psi until the particles are rolled into spheres. Collect the materials and vacuum dry them to obtain the product.

[0041] Among them, the amount of pure water added is 15% based on the total mass of the mixed powder;

[0042] The vacuum drying temperature was 55°C and the drying time was 4 hours.

[0043] Musk: pungent, warm. Enters the heart and spleen meridians.

[0044] Efficacy: Open the orifices and refresh the mind, promote blood circulation and unblock the menstruation, reduce swelling and relieve pain; Musk, with its strong aroma and pungent and dispersing nature, can travel through the meridians, open the orifices and refresh the mind, and has a good therapeutic effect on closed-type coma. At the same time, it can also promote blood circulation and disperse nodules, reduce swelling and relieve pain, and is often used to treat bruises, carbuncles, swellings and toxins, etc.

[0045] Beneficial effects:

[0046] The traditional Chinese medicine micro-pills prepared by the invention have small particle size and large specific surface area, which are beneficial to the dissolution and absorption of musk and other drug components in the body, thereby improving bioavailability and further improving the efficacy of the prepared traditional Chinese medicine micro-pills.

[0047] The present invention forms Chinese medicine micro-pills by combining various components and mixing active ingredients together, thereby achieving a sustained-release effect of the active ingredients, reducing the dosage and prolonging the efficacy.

[0048] The invention can also reduce the stimulation of the drug to the gastrointestinal tract and reduce the incidence of adverse drug reactions through the combination of various components.

[0049] The invention can enhance the immunity of the body and improve the ability of the body to resist inflammation and pain through the combination of astragalus, musk, wolfberry, angelica, angelica and lead ingredients. It can greatly reduce the occurrence and development of inflammation by enhancing the immunity, thus achieving a significant anti-inflammatory and analgesic effect.

[0050] The combination of musk and astragalus can promote the circulation of Qi and blood. The smooth flow of Qi and blood can help supply blood and transport nutrients to the inflamed area, accelerate the disappearance of inflammation and tissue repair. At the same time, the smooth flow of Qi and blood also helps relieve pain and discomfort.

[0051] By adding the primer, the overall state of the body can be regulated, which greatly improves the local microenvironment, thereby exerting a significant anti-inflammatory and analgesic effect, promoting the dissipation of inflammation and relief of pain. BRIEF DESCRIPTION OF THE DRAWINGS

[0052] Figure 1 The figure is a bar graph showing the number of twisting times of mice in each group. DETAILED DESCRIPTION

[0053] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0054] The following are specific embodiments

[0055] Example 1

[0056] A method for preparing musk-containing Chinese medicine pellets comprises the following steps:

[0057] Weigh the following components by weight: 45 parts of Chinese medicine composition, 30 parts of microcrystalline cellulose, and 10 parts of corn starch;

[0058] The traditional Chinese medicine composition is prepared from astragalus, musk, wolfberry, angelica, angelica dahurica and lead as raw materials.

[0059] The method for preparing the Chinese medicine composition comprises the following steps:

[0060] First, weigh out 10 parts of astragalus, 0.3 parts of musk, 2 parts of wolfberry, 3 parts of angelica, 2 parts of angelica dahurica, and 0.8 parts of lead respectively by weight;

[0061] Firstly, astragalus and water are mixed in a mass ratio of 1:5, and then pulped to obtain astragalus slurry;

[0062] The ethanol solution is added to the astragalus slurry, stirred at a speed of 500r / min for 10min, and then subjected to reflux extraction for 4 hours. After the reflux extraction is completed, it is added to a centrifuge for high-speed centrifugation. After high-speed centrifugation, it is allowed to stand for 30min, and then filtered to remove the filter residue to obtain a filtrate. The filter residue is recycled and extracted 3 times using the same method, and then the multiple filtrates are combined, and the combined filtrate is spray-dried to obtain an astragalus extract; the mixed volume ratio of the astragalus slurry and the ethanol solution is 1:2; the mass fraction of the ethanol solution is 70%. The centrifugal speed of the high-speed centrifugation is 8000r / min; wherein, the high-speed centrifugation time is 20min.

[0063] Drying the wolfberries to reduce their moisture content to less than 5%, and then crushing them to obtain wolfberry powder;

[0064] Wherein, drying is carried out by microwave drying;

[0065] The power of microwave drying was 350W;

[0066] Add angelica and white angelica to the mixer in sequence. After mixing for 10 minutes, add water 12 times the mass of angelica and continue mixing for 10 minutes. Then transfer to a frying furnace, heat to 100°C, keep warm for 10 minutes, and then fry slowly over low heat. After cooling, filter to remove solid residue to obtain a decoction; the slow frying time is 2 hours.

[0067] The decoction is spray-dried to obtain a mixed extract;

[0068] The priming material is: ginger juice;

[0069] Astragalus extract, wolfberry powder, mixed extract, musk and ginger juice are mixed together, stirred evenly, and then dried to obtain a traditional Chinese medicine composition;

[0070] The drying temperature was 65°C and the drying time was 4 hours.

[0071] Ginger juice preparation method is:

[0072] Peel the fresh ginger;

[0073] Slice the peeled ginger to obtain ginger slices;

[0074] Soak the ginger slices in water and then take them out;

[0075] The soaked ginger slices are added to a juicer, and water 10% of the weight of the ginger slices is added, and the ginger juice is obtained by squeezing.

[0076] Soak for:

[0077] Mix ginger slices and water in a mass ratio of 1:15, adjust the temperature to 40°C, soak for 1 hour, and then take out.

[0078] Add each component to a universal grinder in turn, mix and grind to obtain a mixed powder;

[0079] Add pure water to the mixed powder, continue mixing, and then extrude and granulate through an extruder at 45 rpm. The particles are spheronized at high speed for 40 min at a speed of 1200 rpm, a blast frequency of 15 Hz, a peristaltic pump speed of 12 rpm, and an atomization pressure of 0.78 psi until the particles are rolled into spheres. Collect the materials and vacuum dry them to obtain the product.

[0080] Among them, the amount of pure water added is 15% based on the total mass of the mixed powder;

[0081] The vacuum drying temperature was 55°C and the drying time was 4 hours.

[0082] Example 2

[0083] A method for preparing musk-containing Chinese medicine pellets comprises the following steps:

[0084] Weigh the components according to their weight: 47 parts of Chinese medicine composition, 32 parts of microcrystalline cellulose, and 11 parts of corn starch;

[0085] The traditional Chinese medicine composition is prepared from astragalus, musk, wolfberry, angelica, angelica dahurica and lead as raw materials.

[0086] The method for preparing the Chinese medicine composition comprises the following steps:

[0087] First, weigh out by weight: 12 parts of Astragalus, 0.35 parts of Musk, 3 parts of Lycium barbarum, 4 parts of Angelica sinensis, 3 parts of Angelica dahurica, and 1 part of primer;

[0088] Firstly, astragalus and water are mixed in a mass ratio of 1:5, and then pulped to obtain astragalus slurry;

[0089] The ethanol solution is added to the astragalus slurry, stirred at a speed of 500r / min for 10min, and then subjected to reflux extraction for 4 hours. After the reflux extraction is completed, it is added to a centrifuge for high-speed centrifugation. After high-speed centrifugation, it is allowed to stand for 30min, and then filtered to remove the filter residue to obtain a filtrate. The filter residue is recycled and extracted 3 times using the same method, and then the multiple filtrates are combined, and the combined filtrate is spray-dried to obtain an astragalus extract; the mixed volume ratio of the astragalus slurry and the ethanol solution is 1:2; the mass fraction of the ethanol solution is 70%. The centrifugal speed of the high-speed centrifugation is 8000r / min; wherein, the high-speed centrifugation time is 20min.

[0090] Drying the wolfberries to reduce their moisture content to less than 5%, and then crushing them to obtain wolfberry powder;

[0091] Wherein, drying is carried out by microwave drying;

[0092] The power of microwave drying was 350W;

[0093] Add angelica and white angelica to the mixer in sequence. After mixing for 10 minutes, add water 12 times the mass of angelica and continue mixing for 10 minutes. Then transfer to a frying furnace, heat to 100°C, keep warm for 10 minutes, and then fry slowly over low heat. After cooling, filter to remove solid residue to obtain a decoction; the slow frying time is 2 hours.

[0094] The decoction is spray-dried to obtain a mixed extract;

[0095] The priming material is: ginger juice;

[0096] Astragalus extract, wolfberry powder, mixed extract, musk and ginger juice are mixed together, stirred evenly, and then dried to obtain a traditional Chinese medicine composition;

[0097] The drying temperature was 65°C and the drying time was 4 hours.

[0098] Ginger juice preparation method is:

[0099] Peel the fresh ginger;

[0100] Slice the peeled ginger to obtain ginger slices;

[0101] Soak the ginger slices in water and then take them out;

[0102] The soaked ginger slices are added to a juicer, and water 10% of the weight of the ginger slices is added, and the ginger juice is obtained by squeezing.

[0103] Soak for:

[0104] Mix ginger slices and water in a mass ratio of 1:15, adjust the temperature to 40°C, soak for 1 hour, and then take out.

[0105] Add each component to a universal grinder in turn, mix and grind to obtain a mixed powder;

[0106] Add pure water to the mixed powder, continue mixing, and then extrude and granulate through an extruder at 45 rpm. The particles are spheronized at high speed for 40 min at a speed of 1200 rpm, a blast frequency of 15 Hz, a peristaltic pump speed of 12 rpm, and an atomization pressure of 0.78 psi until the particles are rolled into spheres. Collect the materials and vacuum dry them to obtain the product.

[0107] Among them, the amount of pure water added is 15% based on the total mass of the mixed powder;

[0108] The vacuum drying temperature was 55°C and the drying time was 4 hours.

[0109] Example 3

[0110] A method for preparing musk-containing Chinese medicine pellets comprises the following steps:

[0111] Weigh the components according to their weight: 48 parts of Chinese medicine composition, 33 parts of microcrystalline cellulose, and 11 parts of corn starch;

[0112] The traditional Chinese medicine composition is prepared from astragalus, musk, wolfberry, angelica, angelica dahurica and lead as raw materials.

[0113] The method for preparing the Chinese medicine composition comprises the following steps:

[0114] First, weigh out by weight: 12 parts of astragalus, 0.4 parts of musk, 5 parts of wolfberry, 4 parts of angelica, 3 parts of angelica dahurica, and 1.2 parts of lead;

[0115] Firstly, astragalus and water are mixed in a mass ratio of 1:5, and then pulped to obtain astragalus slurry;

[0116] The ethanol solution is added to the astragalus slurry, stirred at a speed of 500r / min for 10min, and then subjected to reflux extraction for 4 hours. After the reflux extraction is completed, it is added to a centrifuge for high-speed centrifugation. After high-speed centrifugation, it is allowed to stand for 30min, and then filtered to remove the filter residue to obtain a filtrate. The filter residue is recycled and extracted 3 times using the same method, and then the multiple filtrates are combined, and the combined filtrate is spray-dried to obtain an astragalus extract; the mixed volume ratio of the astragalus slurry and the ethanol solution is 1:2; the mass fraction of the ethanol solution is 70%. The centrifugal speed of the high-speed centrifugation is 8000r / min; wherein, the high-speed centrifugation time is 20min.

[0117] Drying the wolfberries to reduce their moisture content to less than 5%, and then crushing them to obtain wolfberry powder;

[0118] Wherein, drying is carried out by microwave drying;

[0119] The power of microwave drying was 350W;

[0120] Add angelica and white angelica to the mixer in sequence. After mixing for 10 minutes, add water 12 times the mass of angelica and continue mixing for 10 minutes. Then transfer to a frying furnace, heat to 100°C, keep warm for 10 minutes, and then fry slowly over low heat. After cooling, filter to remove solid residue to obtain a decoction; the slow frying time is 2 hours.

[0121] The decoction is spray-dried to obtain a mixed extract;

[0122] The priming material is: ginger juice;

[0123] Astragalus extract, wolfberry powder, mixed extract, musk and ginger juice are mixed together, stirred evenly, and then dried to obtain a traditional Chinese medicine composition;

[0124] The drying temperature was 65°C and the drying time was 4 hours.

[0125] Ginger juice preparation method is:

[0126] Peel the fresh ginger;

[0127] Slice the peeled ginger to obtain ginger slices;

[0128] Soak the ginger slices in water and then take them out;

[0129] The soaked ginger slices are added to a juicer, and water 10% of the weight of the ginger slices is added, and the ginger juice is obtained by squeezing.

[0130] Soak for:

[0131] Mix ginger slices and water in a mass ratio of 1:15, adjust the temperature to 40°C, soak for 1 hour, and then take out.

[0132] Add each component to a universal grinder in turn, mix and grind to obtain a mixed powder;

[0133] Add pure water to the mixed powder, continue mixing, and then extrude and granulate through an extruder at 45 rpm. The particles are spheronized at high speed for 40 min at a speed of 1200 rpm, a blast frequency of 15 Hz, a peristaltic pump speed of 12 rpm, and an atomization pressure of 0.78 psi until the particles are rolled into spheres. Collect the materials and vacuum dry them to obtain the product.

[0134] Among them, the amount of pure water added is 15% based on the total mass of the mixed powder;

[0135] The vacuum drying temperature was 55°C and the drying time was 4 hours.

[0136] Example 4

[0137] A method for preparing musk-containing Chinese medicine pellets comprises the following steps:

[0138] Weigh the components according to their weight: 48 parts of Chinese medicine composition, 34 parts of microcrystalline cellulose, and 10 parts of corn starch;

[0139] The traditional Chinese medicine composition is prepared from astragalus, musk, wolfberry, angelica, angelica dahurica and lead as raw materials.

[0140] The method for preparing the Chinese medicine composition comprises the following steps:

[0141] First, weigh out 12 parts of astragalus, 0.4 parts of musk, 5 parts of wolfberry, 5 parts of angelica, 3 parts of angelica, and 1.2 parts of lead respectively by weight;

[0142] Firstly, astragalus and water are mixed in a mass ratio of 1:5, and then pulped to obtain astragalus slurry;

[0143] The ethanol solution is added to the astragalus slurry, stirred at a speed of 500r / min for 10min, and then subjected to reflux extraction for 4 hours. After the reflux extraction is completed, it is added to a centrifuge for high-speed centrifugation. After high-speed centrifugation, it is allowed to stand for 30min, and then filtered to remove the filter residue to obtain a filtrate. The filter residue is recycled and extracted 3 times using the same method, and then the multiple filtrates are combined, and the combined filtrate is spray-dried to obtain an astragalus extract; the mixed volume ratio of the astragalus slurry and the ethanol solution is 1:2; the mass fraction of the ethanol solution is 70%. The centrifugal speed of the high-speed centrifugation is 8000r / min; wherein, the high-speed centrifugation time is 20min.

[0144] Drying the wolfberries to reduce their moisture content to less than 5%, and then crushing them to obtain wolfberry powder;

[0145] Wherein, drying is carried out by microwave drying;

[0146] The power of microwave drying was 350W;

[0147] Add angelica and white angelica to the mixer in sequence. After mixing for 10 minutes, add water 12 times the mass of angelica and continue mixing for 10 minutes. Then transfer to a frying furnace, heat to 100°C, keep warm for 10 minutes, and then fry slowly over low heat. After cooling, filter to remove solid residue to obtain a decoction; the slow frying time is 2 hours.

[0148] The decoction is spray-dried to obtain a mixed extract;

[0149] The priming material is: ginger juice;

[0150] Astragalus extract, wolfberry powder, mixed extract, musk and ginger juice are mixed together, stirred evenly, and then dried to obtain a traditional Chinese medicine composition;

[0151] The drying temperature was 65°C and the drying time was 4 hours.

[0152] Ginger juice preparation method is:

[0153] Peel the fresh ginger;

[0154] Slice the peeled ginger to obtain ginger slices;

[0155] Soak the ginger slices in water and then take them out;

[0156] The soaked ginger slices are added to a juicer, and water 10% of the weight of the ginger slices is added, and the ginger juice is obtained by squeezing.

[0157] Soak for:

[0158] Mix ginger slices and water in a mass ratio of 1:15, adjust the temperature to 40°C, soak for 1 hour, and then take out.

[0159] Add each component to a universal grinder in turn, mix and grind to obtain a mixed powder;

[0160] Add pure water to the mixed powder, continue mixing, and then extrude and granulate through an extruder at 45 rpm. The particles are spheronized at high speed for 40 min at a speed of 1200 rpm, a blast frequency of 15 Hz, a peristaltic pump speed of 12 rpm, and an atomization pressure of 0.78 psi until the particles are rolled into spheres. Collect the materials and vacuum dry them to obtain the product.

[0161] Among them, the amount of pure water added is 15% based on the total mass of the mixed powder;

[0162] The vacuum drying temperature was 55°C and the drying time was 4 hours.

[0163] Example 5

[0164] A method for preparing musk-containing Chinese medicine pellets comprises the following steps:

[0165] Weigh the components according to their weight: 50 parts of Chinese medicine composition, 35 parts of microcrystalline cellulose, and 12 parts of corn starch;

[0166] The traditional Chinese medicine composition is prepared from astragalus, musk, wolfberry, angelica, angelica dahurica and lead as raw materials.

[0167] The method for preparing the Chinese medicine composition comprises the following steps:

[0168] First, weigh out 15 parts of astragalus, 0.5 parts of musk, 8 parts of wolfberry, 6 parts of angelica, 4 parts of angelica dahurica, and 1.5 parts of lead respectively by weight;

[0169] Firstly, astragalus and water are mixed in a mass ratio of 1:5, and then pulped to obtain astragalus slurry;

[0170] The ethanol solution is added to the astragalus slurry, stirred at a speed of 500r / min for 10min, and then subjected to reflux extraction for 4 hours. After the reflux extraction is completed, it is added to a centrifuge for high-speed centrifugation. After high-speed centrifugation, it is allowed to stand for 30min, and then filtered to remove the filter residue to obtain a filtrate. The filter residue is recycled and extracted 3 times using the same method, and then the multiple filtrates are combined, and the combined filtrate is spray-dried to obtain an astragalus extract; the mixed volume ratio of the astragalus slurry and the ethanol solution is 1:2; the mass fraction of the ethanol solution is 70%. The centrifugal speed of the high-speed centrifugation is 8000r / min; wherein, the high-speed centrifugation time is 20min.

[0171] Drying the wolfberries to reduce their moisture content to less than 5%, and then crushing them to obtain wolfberry powder;

[0172] Wherein, drying is carried out by microwave drying;

[0173] The power of microwave drying was 350W;

[0174] Add angelica and white angelica to the mixer in sequence. After mixing for 10 minutes, add water 12 times the mass of angelica and continue mixing for 10 minutes. Then transfer to a frying furnace, heat to 100°C, keep warm for 10 minutes, and then fry slowly over low heat. After cooling, filter to remove solid residue to obtain a decoction; the slow frying time is 2 hours.

[0175] The decoction is spray-dried to obtain a mixed extract;

[0176] The priming material is: ginger juice;

[0177] Astragalus extract, wolfberry powder, mixed extract, musk and ginger juice are mixed together, stirred evenly, and then dried to obtain a traditional Chinese medicine composition;

[0178] The drying temperature was 65°C and the drying time was 4 hours.

[0179] Ginger juice preparation method is:

[0180] Peel the fresh ginger;

[0181] Slice the peeled ginger to obtain ginger slices;

[0182] Soak the ginger slices in water and then take them out;

[0183] The soaked ginger slices are added to a juicer, and water 10% of the weight of the ginger slices is added, and the ginger juice is obtained by squeezing.

[0184] Soak for:

[0185] Mix ginger slices and water in a mass ratio of 1:15, adjust the temperature to 40°C, soak for 1 hour, and then take out.

[0186] Add each component to a universal grinder in turn, mix and grind to obtain a mixed powder;

[0187] Add pure water to the mixed powder, continue mixing, and then extrude and granulate through an extruder at 45 rpm. The particles are spheronized at high speed for 40 min at a speed of 1200 rpm, a blast frequency of 15 Hz, a peristaltic pump speed of 12 rpm, and an atomization pressure of 0.78 psi until the particles are rolled into spheres. Collect the materials and vacuum dry them to obtain the product.

[0188] Among them, the amount of pure water added is 15% based on the total mass of the mixed powder;

[0189] The vacuum drying temperature was 55°C and the drying time was 4 hours.

[0190] Comparative Example 1:

[0191] Based on the technical solution of Example 1, the difference from the technical solution of Example 1 is that no primer is added.

[0192] Comparative Example 2:

[0193] Based on the technical solution of Example 1, the difference from the technical solution of Example 1 is that no musk is added.

[0194] test:

[0195] The Chinese medicine pellets were prepared by the method of the embodiment, and the qualified rate of pellets of each group was counted;

[0196] Among them, the qualified rate of pelleting (%) = weight of pellets after drying / total weight of feed × 100%;

[0197] Table 1

[0198]

[0199]

[0200] It can be seen from Table 1 that the qualified rate of the Chinese medicine pellets prepared by the method of the present invention is relatively high, and the average qualified rate is greater than 98%, indicating that the loss in the preparation process of the Chinese medicine pellets is relatively small.

[0201] The parameters of the pellets prepared in Example 1 were recorded:

[0202] Table 2

[0203] parameter Bulk density g / mL 0.85 <![CDATA[Specific surface area g / m 2 > 0.038 Particle size mm 1.2

[0204] It can be seen from Table 2 that the micropellets prepared by the present invention have relatively suitable apparent parameters.

[0205] 144 ICR mice, half male and half female, with an average body weight of 22±1g, were used as a distilled water blank control group, and the pellets of the embodiment and the comparative example were gavaged daily, with a pellet dose of 0.2g / kg and 10mL of distilled water per day for 4 consecutive days. 1.5 hours after the last administration, 0.65% glacial acetic acid 0.1ml / 10g was intravenously injected into the ICR mice;

[0206] Record the number of twists of each mouse within 20 minutes after injection of the analgesic:

[0207] Table 3

[0208]

[0209] It can be seen from Table 3 that the Chinese medicine pellets prepared by the present invention have a more significant analgesic effect.

[0210] The above description is only a preferred embodiment of the present invention, but the present invention is not limited to the scope of implementation shown. Any changes made in accordance with the concept of the present invention, or modifications to equivalent embodiments with equivalent changes, which still do not exceed the spirit covered by the specification, should be within the protection scope of the present invention.

Claims

1. A Chinese medicine pellet containing musk, It is characterized in that The composition comprises the following components by weight: 45-50 parts of the Chinese medicine composition, 30-35 parts of the diluent, and 10-12 parts of the binder; The traditional Chinese medicine composition is prepared from astragalus, musk, wolfberry, angelica, angelica dahurica and lead as raw materials.

2. The musk-containing Chinese medicine pellet according to claim 1, Features: The method for preparing the Chinese medicine composition comprises the following steps: First, weigh out by weight: 10-15 parts of astragalus, 0.3-0.5 parts of musk, 2-8 parts of wolfberry, 3-6 parts of angelica, 2-4 parts of angelica, and 0.8-1.5 parts of lead; Firstly, astragalus and water are mixed in a mass ratio of 1:5, and then pulped to obtain astragalus slurry; Adding ethanol solution to the astragalus slurry, stirring at a speed of 500r / min for 10min, and then performing reflux extraction for 4 hours. After the reflux extraction is completed, adding it to a centrifuge for high-speed centrifugation. After high-speed centrifugation, standing for 30min, and then filtering to remove the filter residue to obtain a filtrate, recycling the filter residue for 3 times using the same method, and then combining the multiple filtrates, and spray drying the combined filtrates to obtain an astragalus extract; Drying the wolfberries to reduce their moisture content to less than 5%, and then crushing them to obtain wolfberry powder; Wherein, drying is carried out by microwave drying; The power of microwave drying was 350W; Add angelica and angelica dahurica to the mixer in sequence, mix for 10 minutes, then add water 12 times the weight of angelica, continue mixing for 10 minutes, then transfer to a frying furnace, heat to 100°C, keep warm for 10 minutes, then fry slowly over low heat, filter after cooling, remove solid residue, and obtain a decoction; The decoction is spray-dried to obtain a mixed extract; The priming material is: ginger juice; Astragalus extract, wolfberry powder, mixed extract, musk and ginger juice are mixed together, stirred evenly, and then dried to obtain a traditional Chinese medicine composition; The drying temperature was 65°C and the drying time was 4 hours.

3. The musk-containing Chinese medicine pellets as claimed in claim 2, Features: The volume ratio of the astragalus slurry and ethanol solution was 1:2; The mass fraction of the ethanol solution is 70%.

4. The musk-containing Chinese medicine pellet according to claim 2, Features: The centrifugal speed of the high-speed centrifugation is 8000 r / min; Among them, the high-speed centrifugation treatment time is 20 minutes.

5. The musk-containing Chinese medicine pellet according to claim 4, Features: The slow frying time is 2-3 hours.

6. The musk-containing Chinese medicine pellet according to claim 4, Features: The ginger juice preparation method is: Peel the fresh ginger; Slice the peeled ginger to obtain ginger slices; Soak the ginger slices in water and then take them out; The soaked ginger slices are added to a juicer, and water 10% of the weight of the ginger slices is added, and the ginger juice is obtained by squeezing.

7. The musk-containing Chinese medicine pellet according to claim 6, Features: The soaking is: Mix ginger slices and water in a mass ratio of 1:15, adjust the temperature to 40°C, soak for 1 hour, and then take out.

8. The musk-containing Chinese medicine pellet according to claim 1, Features: The diluent is microcrystalline cellulose.

9. The musk-containing Chinese medicine pellet according to claim 1, Features: The adhesive is starch; The starch is corn starch.

10. A method for preparing musk-containing Chinese medicine pellets according to claim 1, Features: The following steps are involved: Weigh each component according to its weight; Add each component to a universal grinder in turn, mix and grind to obtain a mixed powder; Add pure water to the mixed powder, continue mixing, and then extrude and granulate through an extruder at 45 rpm. The particles are spheronized at high speed for 40 min at a speed of 1200 rpm, a blast frequency of 15 Hz, a peristaltic pump speed of 12 rpm, and an atomization pressure of 0.78 psi until the particles are rolled into spheres. Collect the materials and vacuum dry them to obtain the product. Among them, the amount of pure water added is 15% based on the total mass of the mixed powder; The vacuum drying temperature was 55°C and the drying time was 4 hours.

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