Contrast agent dose determination method and device, computer equipment and storage medium

Abstract

The invention relates to a contrast agent dose determination method and device, computer equipment and a storage medium. The method comprises the steps of determining a reference protocol of scanning equipment according to a scanning object, obtaining multiple groups of recommendation protocols based on scanning parameter information of the scanning equipment, selecting a protocol with the minimum X-ray radiation dose applied to the scanning object from the reference protocol and the multiple groups of recommendation protocols as a target protocol, and determining the X-ray radiation dose applied to the scanning object according to the target protocol and preset contrast agent concentration. A target contrast agent dose is determined. Since the usage amount of the contrast agent can be reduced by reducing the tube voltage, in the embodiment of the invention, the protocol with the minimum X-ray radiation dose applied to the scanned object is selected from the reference protocol and the multiple groups of recommendation protocols as the target protocol, so that the contrast agent dose can be effectively reduced on the premise of ensuring the image quality, and the imaging efficiency is improved. Therefore, the effectiveness and safety of patient examination are further improved. The multiple groups of recommendation protocols are determined according to the scanning parameter information of the scanning equipment, so that the determined target protocol is more targeted.

Description

Technical Field

[0001] The present application relates to the field of medical technology, and in particular to a contrast agent dosage determination method, apparatus, computer equipment and storage medium. Background Art

[0002] The appropriate contrast agent dose is related to image quality, patient safety, and diagnostic accuracy. Before performing an enhanced scan, the doctor will comprehensively evaluate various factors to determine the most appropriate dose to ensure the effectiveness of the examination and the safety of the patient.

[0003] Currently, the contrast agent dosage is determined by the patient's weight, iodine contrast agent concentration, contrast agent flow rate, etc.

[0004] However, the current method for determining the contrast agent dose can only obtain a safe dose plan, and cannot obtain the optimal dose that meets the requirements. Summary of the invention

[0005] Based on this, it is necessary to provide a contrast agent dosage determination method, apparatus, computer equipment and storage medium that can improve the accuracy of contrast agent determination in order to solve the above technical problems.

[0006] In a first aspect, the present application provides a contrast agent dosage determination method, comprising:

[0007] Determine a reference protocol of the scanning device according to the scanning object; the reference protocol includes a reference minimum tube voltage and a reference maximum tube current exposure of the tube in the scanning device;

[0008] Based on the scanning parameter information of the scanning device, a plurality of groups of recommended protocols are obtained; each of the recommended protocols includes a recommended minimum tube voltage and a recommended maximum tube current exposure of the tube, and the contrast-to-noise ratio of the reconstructed image obtained under each of the recommended protocols meets the requirements; the scanning parameter information includes at least one of a scanning pitch, a scanning time, and a rotation time;

[0009] Selecting, from the reference protocol and the plurality of groups of recommended protocols, a protocol that minimizes the X-ray radiation dose applied to the scanned object as a target protocol;

[0010] A target contrast agent dose is determined according to the target protocol and a preset contrast agent concentration.

[0011] In one embodiment, the scanning parameter information further includes a standard value; and obtaining multiple groups of recommended protocols based on the scanning parameter information of the scanning device includes:

[0012] For each preset scanning length, determining the scanning time according to the scanning length, the alignment value, the scanning pitch and the rotation time;

[0013] Obtaining a product of the reference maximum tube current exposure, the scanning pitch and the scanning time, and taking a ratio of the product to the rotation time as the recommended maximum tube current exposure;

[0014] Determining each of the recommended minimum tube voltages that meets the contrast-to-noise ratio requirement according to the reference minimum tube voltage and each of the recommended maximum tube current exposures;

[0015] The recommended minimum tube voltage and the corresponding recommended maximum tube current exposure are taken as the recommended protocols.

[0016] In one embodiment, the target protocol includes a target minimum tube voltage and a target maximum tube current exposure; and determining a target contrast agent dose according to the target protocol and a preset contrast agent concentration includes:

[0017] determining an initial contrast agent dose according to the target minimum tube voltage, the target maximum tube current exposure, and the contrast agent concentration;

[0018] Determine the weight coefficient based on the target contrast-to-noise ratio in the reference reconstructed image; the reference reconstructed image is obtained by reconstructing the reference projection data using an image reconstruction algorithm that meets the image enhancement requirements, and the reference projection data is data simulated and collected under the exposure amount of the target minimum tube voltage and the target maximum tube current;

[0019] The initial contrast agent dose is corrected based on the weight coefficient to obtain the target contrast agent dose.

[0020] In one embodiment, the method further comprises:

[0021] determining an image noise value and an image contrast based on the CT value in the reference reconstructed image;

[0022] The ratio of the image contrast to the image noise value is used as the target contrast-to-noise ratio.

[0023] In one embodiment, determining each of the recommended minimum tube voltages that meets the contrast-to-noise ratio requirement based on the reference minimum tube voltage and each of the recommended maximum tube current exposures includes:

[0024] For each of the recommended maximum tube current exposures, determining a first contrast-to-noise ratio according to the reference minimum tube voltage and the recommended maximum tube current exposure;

[0025] If the first contrast-to-noise ratio is greater than a preset noise ratio, it is determined that the first contrast-to-noise ratio meets the contrast-to-noise ratio requirement, and the reference minimum tube voltage is used as the recommended minimum tube voltage.

[0026] In one embodiment, the method further comprises:

[0027] If the first contrast-to-noise ratio is less than or equal to the preset noise ratio, increasing the reference minimum tube voltage to obtain a plurality of candidate tube voltages;

[0028] determining a plurality of second contrast-to-noise ratios based on the plurality of candidate tube voltages and the recommended maximum tube current exposure;

[0029] determining a second contrast-to-noise ratio greater than the preset noise ratio as a target contrast-to-noise ratio;

[0030] The lowest candidate tube voltage corresponding to the target contrast-to-noise ratio is used as the recommended minimum tube voltage.

[0031] In one embodiment, determining a reference protocol of a scanning device according to a scanning object comprises:

[0032] Determining a reference minimum tube voltage according to a target body mass index of the scanned object and a first preset corresponding relationship; the first preset corresponding relationship includes a corresponding relationship between different body mass index intervals and different minimum tube voltages;

[0033] A reference maximum tube current exposure is determined according to the target scanning part of the scanning object and a second preset corresponding relationship; the second preset corresponding relationship includes a corresponding relationship between different scanning parts and different maximum tube current exposure amounts.

[0034] In a second aspect, the present application also provides a contrast agent dosage determination device, comprising:

[0035] A first determination module is used to determine a reference protocol of a scanning device according to a scanning object; the reference protocol includes a reference minimum tube voltage and a reference maximum tube current exposure of a tube in the scanning device;

[0036] an acquisition module, configured to acquire multiple groups of recommended protocols based on the scanning parameter information of the scanning device; each of the recommended protocols includes a recommended minimum tube voltage and a recommended maximum tube current exposure of the tube, and the contrast-to-noise ratio of the reconstructed image obtained under each of the recommended protocols meets the requirements; the scanning parameter information includes at least one of a scanning pitch, a scanning time, and a rotation time;

[0037] A selection module, configured to select, from the reference protocol and the plurality of groups of recommended protocols, a protocol with a minimum X-ray radiation dose applied to the scanned object as a target protocol;

[0038] The second determination module is used to determine a target contrast agent dose according to the target protocol and a preset contrast agent concentration.

[0039] In a third aspect, the present application further provides a computer device, including a memory and a processor, wherein the memory stores a computer program, and when the processor executes the computer program, the following steps are implemented:

[0040] Determine a reference protocol of the scanning device according to the scanning object; the reference protocol includes a reference minimum tube voltage and a reference maximum tube current exposure of the tube in the scanning device;

[0041] Based on the scanning parameter information of the scanning device, a plurality of groups of recommended protocols are obtained; each of the recommended protocols includes a recommended minimum tube voltage and a recommended maximum tube current exposure of the tube, and the contrast-to-noise ratio of the reconstructed image obtained under each of the recommended protocols meets the requirements; the scanning parameter information includes at least one of a scanning pitch, a scanning time, and a rotation time;

[0042] Selecting, from the reference protocol and the plurality of groups of recommended protocols, a protocol that minimizes the X-ray radiation dose applied to the scanned object as a target protocol;

[0043] A target contrast agent dose is determined according to the target protocol and a preset contrast agent concentration.

[0044] In a fourth aspect, the present application further provides a computer-readable storage medium having a computer program stored thereon, wherein when the computer program is executed by a processor, the following steps are implemented:

[0045] Determine a reference protocol of the scanning device according to the scanning object; the reference protocol includes a reference minimum tube voltage and a reference maximum tube current exposure of the tube in the scanning device;

[0046] Based on the scanning parameter information of the scanning device, a plurality of groups of recommended protocols are obtained; each of the recommended protocols includes a recommended minimum tube voltage and a recommended maximum tube current exposure of the tube, and the contrast-to-noise ratio of the reconstructed image obtained under each of the recommended protocols meets the requirements; the scanning parameter information includes at least one of a scanning pitch, a scanning time, and a rotation time;

[0047] Selecting, from the reference protocol and the plurality of groups of recommended protocols, a protocol that minimizes the X-ray radiation dose applied to the scanned object as a target protocol;

[0048] A target contrast agent dose is determined according to the target protocol and a preset contrast agent concentration.

[0049] In a fifth aspect, the present application further provides a computer program product, including a computer program, which implements the following steps when executed by a processor:

[0050] Determine a reference protocol of the scanning device according to the scanning object; the reference protocol includes a reference minimum tube voltage and a reference maximum tube current exposure of the tube in the scanning device;

[0051] Based on the scanning parameter information of the scanning device, a plurality of groups of recommended protocols are obtained; each of the recommended protocols includes a recommended minimum tube voltage and a recommended maximum tube current exposure of the tube, and the contrast-to-noise ratio of the reconstructed image obtained under each of the recommended protocols meets the requirements; the scanning parameter information includes at least one of a scanning pitch, a scanning time, and a rotation time;

[0052] Selecting, from the reference protocol and the plurality of groups of recommended protocols, a protocol that minimizes the X-ray radiation dose applied to the scanned object as a target protocol;

[0053] A target contrast agent dose is determined according to the target protocol and a preset contrast agent concentration.

[0054] The above contrast agent dose determination method, device, computer device and storage medium determine the reference protocol of the scanning device according to the scanned object, obtain multiple groups of recommended protocols based on the scanning parameter information of the scanning device, select the protocol with the minimum X-ray radiation dose applied to the scanned object from the reference protocol and the multiple groups of recommended protocols as the target protocol, and determine the target contrast agent dose according to the target protocol and the preset contrast agent concentration, the reference protocol includes the reference minimum tube voltage and the reference maximum tube current exposure of the tube in the scanning device, each recommended protocol includes the recommended minimum tube voltage and the recommended maximum tube current exposure of the tube, and the contrast-to-noise ratio of the reconstructed image obtained under each recommended protocol meets the requirements; the scanning parameter information includes at least one of the scanning pitch, the scanning time and the rotation time. Since the amount of contrast agent used can be reduced by reducing the tube voltage, in the embodiment of the present application, the protocol with the minimum X-ray radiation dose applied to the scanned object is selected as the target protocol from the reference protocol and the multiple groups of recommended protocols, which can effectively reduce the contrast agent dose while ensuring the image quality, so that the effectiveness and safety of the patient's enhanced examination are further improved. Moreover, multiple groups of recommended protocols are determined based on the scanning parameter information of the scanning device, which can make the determined target protocol more targeted. BRIEF DESCRIPTION OF THE DRAWINGS

[0055] In order to more clearly illustrate the technical solutions in the embodiments of the present application or related technologies, the drawings required for use in the embodiments of the present application or related technical descriptions will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other related drawings can be obtained based on these drawings without paying creative work.

[0056] FIG1 is a diagram showing an application environment of a method for determining a contrast agent dosage in one embodiment;

[0057] FIG2 is a schematic flow chart of a method for determining a contrast agent dosage in one embodiment;

[0058] FIG3 is a schematic flow chart of a method for determining a target contrast agent dose in one embodiment;

[0059] FIG4 is a schematic flow chart of a method for determining a recommended minimum tube voltage in one embodiment;

[0060] FIG5 is a schematic flow chart of a method for determining a contrast agent dosage in another embodiment;

[0061] FIG6 is a flow chart of a method for determining a contrast agent dosage in another embodiment;

[0062] FIG. 7 is a structural block diagram of a contrast agent dosage determination device in one embodiment. DETAILED DESCRIPTION

[0063] In order to make the purpose, technical solution and advantages of the present application more clearly understood, the present application is further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present application and are not used to limit the present application.

[0064] Computed Tomography (CT) can include plain scans and enhanced scans. During CT enhanced scans, for conventional enhanced scans such as cranial enhancement, chest enhancement, neck enhancement, abdominal enhancement, and urinary system enhancement; CT arteriography (CTA) such as lower limb CTA and upper limb artery angiography CTA; head and neck CTA, aortic CTA, abdomen, coronary CTA head, chest, and abdomen CTA; and brain perfusion, body liver perfusion, body kidney perfusion, and other parts, patients will need to be injected with contrast agents / contrast agents. Contrast agents / contrast agents not only cause certain harm and side effects to patients, but also have risks such as contrast agent / contrast agent leakage. Therefore, it is necessary to propose a contrast agent dosage determination method that can determine a more accurate contrast agent dosage.

[0065] The contrast agent dosage determination method provided in the embodiment of the present application can be applied to the application environment shown in Figure 1. The application environment includes a computer device, which can be a server, and its internal structure diagram can be shown in Figure 1. The computer device includes a processor, a memory, an input / output interface (Input / Output, referred to as I / O) and a communication interface. Among them, the processor, the memory and the input / output interface are connected through a system bus, and the communication interface is connected to the system bus through the input / output interface. Among them, the processor of the computer device is used to provide computing and control capabilities. The memory of the computer device includes a non-volatile storage medium and an internal memory. The non-volatile storage medium stores an operating system, a computer program and a database. The internal memory provides an environment for the operation of the operating system and the computer program in the non-volatile storage medium. The database of the computer device is used to store relevant data for contrast agent dosage determination. The input / output interface of the computer device is used to exchange information between the processor and an external device. The communication interface of the computer device is used to communicate with an external terminal through a network connection. When the computer program is executed by the processor, a method for determining a contrast agent dosage is implemented. Optionally, the server may be an independent physical server, a server cluster or a distributed system consisting of multiple physical servers, or a cloud server providing cloud computing services.

[0066] Those skilled in the art will understand that the structure shown in FIG. 1 is merely a block diagram of a partial structure related to the solution of the present application, and does not constitute a limitation on the computer device to which the solution of the present application is applied. The specific computer device may include more or fewer components than shown in the figure, or combine certain components, or have a different arrangement of components.

[0067] In an exemplary embodiment, as shown in FIG2 , a method for determining a contrast agent dosage is provided, which is described by taking the method applied to the computer device in FIG1 as an example, and includes the following S201 to S204. Wherein:

[0068] S201, determining a reference protocol of a scanning device according to a scanning object; the reference protocol includes a reference minimum tube voltage and a reference maximum tube current exposure of a tube in the scanning device.

[0069] Among them, the minimum tube voltage refers to the lowest voltage value used when the tube is working in X-ray detection, and the maximum tube current exposure refers to the maximum load that the tube can withstand under safe use conditions at a specific tube voltage. The minimum tube voltage and maximum tube current exposure are two scanning parameter items in the scanning system of the scanning device.

[0070] In this embodiment, the minimum tube voltage of the tube is usually closely related to the penetration ability, imaging contrast, and the absorbed dose of the patient. In the field of medical radiation, the minimum tube voltage refers to the minimum voltage value required to penetrate a specific part of the human body. Therefore, the reference minimum tube voltage of the tube can be determined according to the target body mass index of the scanned object and the first preset corresponding relationship, and the first preset corresponding relationship includes the correspondence between different body mass index intervals and different minimum tube voltages. Or the reference minimum tube voltage is obtained according to the sum of the body thickness (cm) of the scanned object and the preset voltage value. For example, the trunk is thicker than the limbs and contains more tissue and bone structure, and usually requires a higher tube voltage. The limbs are mainly composed of soft tissue and a small amount of bone, which has less obstruction to X-rays, so a lower tube voltage can be used.

[0071] The maximum tube current exposure determines the overall energy emitted from the tube. For thicker or denser body parts, the exposure may need to be increased to obtain sufficient imaging information. Therefore, the reference maximum tube current exposure of the tube can be determined based on the target scanning part of the scanned object and the second preset correspondence. The second preset correspondence includes the correspondence between different scanning parts and different maximum tube current exposures. Alternatively, the parameter information of the scanning part of the scanned object is input into a pre-trained parameter recommendation model to obtain the reference maximum tube current exposure.

[0072] S202, based on the scanning parameter information of the scanning device, a plurality of groups of recommended protocols are obtained; each recommended protocol includes a recommended minimum tube voltage and a recommended maximum tube current exposure of the tube, and the contrast-to-noise ratio of the reconstructed image obtained under each recommended protocol meets the requirements; the scanning parameter information includes at least one of a scanning pitch, a scanning time and a rotation time.

[0073] Among them, the scanning pitch is the ratio of the distance the scanning bed travels to the width of the X-ray beam when the scanning gantry in the scanning device rotates one circle. The scanning pitch can be preset based on the image quality requirements. The smaller the scanning pitch, the higher the quality of the reconstructed image. The rotation time refers to the time required for the scanning gantry to complete a 360-degree rotation. The shorter the rotation time, the higher the performance of the scanning device, and more image data can be obtained in a shorter time. The rotation time is also a value that can be preset in advance. The scanning time refers to the total time required to complete the entire scanning process.

[0074] The contrast-to-noise ratio is the ratio of the signal intensity difference between the region of interest and other regions in the image to the standard deviation of the background noise. It can be seen that the contrast-to-noise ratio is positively correlated with the image quality. Therefore, when the contrast-to-noise ratio is greater than the preset noise ratio, it is considered that the contrast-to-noise ratio requirement is met.

[0075] In this embodiment, the reference maximum tube current exposure is the maximum tube current exposure under the standard body type recommended based on the target scanning part. However, even under the same type of scanning part, the size information of the scanning part of each patient will be different. The rotation time is also a preset parameter value. Therefore, the embodiment of the present application can determine multiple scanning times of the scanning device based on the size information of the same type of scanning part on different patients. For each scanning time (that is, each size information of the same type of scanning part), the product result of the reference maximum tube current exposure, the scanning pitch and the scanning time is obtained; the ratio of the product result to the rotation time is used as the recommended maximum tube current exposure.

[0076] Furthermore, for each recommended maximum tube current exposure, the recommended minimum tube voltage that meets the contrast-to-noise ratio requirement is determined based on the recommended maximum tube current exposure and the reference minimum tube voltage, and the recommended minimum tube voltage and the recommended maximum tube current exposure are used as the recommended protocol.

[0077] In a possible implementation, a mapping relationship may be established between the size information of each scanning part and the scanning time. For example, for the same type of scanning part, the larger the size of the scanning part, the longer the scanning time.

[0078] In another possible implementation, the scanning length can also be determined based on the size information of the scanning part, and the scanning time can be determined according to the scanning length, the alignment value in the scanning parameter information, the scanning pitch and the rotation time. The alignment value is determined based on the collimator in the scanning device. Different scanning devices have different alignment values. The collimation range of the collimator is generally between 10mm and 100mm.

[0079] S203 , selecting a protocol with the smallest X-ray radiation dose applied to the scanned object from the reference protocol and the plurality of groups of recommended protocols as a target protocol.

[0080] In the embodiment of the present application, there is a positive correlation between the X-ray radiation dose and the minimum tube voltage. Therefore, the reference minimum tube voltage and the multiple recommended minimum tube voltages in the reference protocol and multiple groups of recommended protocols are determined, and the protocol corresponding to the smallest minimum tube voltage is used as the target protocol.

[0081] S204, determining a target contrast agent dose according to the target protocol and the preset contrast agent concentration.

[0082] In the embodiment of the present application, the target protocol includes a target minimum tube voltage and a target maximum tube current exposure. The product result of the target minimum tube voltage and the target maximum tube current exposure can be obtained, and the initial contrast agent dose n0 is determined according to the ratio of the product result and the contrast agent concentration, that is,

[0083] ,

[0084] Wherein, a is the target minimum tube voltage, in kilovolts (KV), b is the target maximum tube current exposure, in milliampere-seconds (mAs), and c is the concentration of the contrast agent, in milliampere-seconds (mg / ml).

[0085] In a possible implementation, the initial contrast agent dose may be directly used as the target contrast agent dose.

[0086] In another possible implementation, since the greater the tube voltage, the lower the contrast of the image to be reconstructed, the contrast of the image to be reconstructed can be enhanced by an image reconstruction algorithm so that the contrast of the image to be reconstructed is the same as the contrast under low tube voltage. For example, the reference minimum tube voltage is 60KV, and the target minimum tube voltage is 80KV. The contrast of the image to be reconstructed under 60KV, 200mAs is greater than the contrast of the image to be reconstructed under 80KV, 200mAs. Under the condition of satisfying the contrast signal-to-noise ratio, in order to make the contrast of the image to be reconstructed under 80KV, 200mAs the same as the image contrast of 60KV, 200mAs, the image can be enhanced by an image reconstruction algorithm to improve the contrast. Since the contrast agent dose corresponding to 60KV, 200mAs is less than the contrast agent dose corresponding to 80KV, 200mAs, the image quality effect of the contrast agent dose corresponding to 60KV, 200mAs can be achieved by the image reconstruction algorithm.

[0087] Therefore, the reference projection data of the scanned part of the scanned object can be simulated and collected based on the target minimum tube voltage and the target maximum tube current exposure, and the reference projection data can be reconstructed to obtain a reference reconstructed image. The weight coefficient can be obtained by using the target contrast-to-noise ratio in the reference reconstructed image, and the initial contrast agent dose can be modified based on the weight coefficient to obtain the target contrast agent dose.

[0088] In the above contrast agent dose determination method, a reference protocol of the scanning device is determined according to the scanned object, and multiple groups of recommended protocols are obtained based on the scanning parameter information of the scanning device. From the reference protocol and the multiple groups of recommended protocols, a protocol with the minimum X-ray radiation dose applied to the scanned object is selected as the target protocol. According to the target protocol and the preset contrast agent concentration, the target contrast agent dose is determined. The reference protocol includes the reference minimum tube voltage and the reference maximum tube current exposure of the tube in the scanning device, and each recommended protocol includes the recommended minimum tube voltage and the recommended maximum tube current exposure of the tube, and the contrast-to-noise ratio of the reconstructed image obtained under each recommended protocol meets the requirements; the scanning parameter information includes at least one of the scanning pitch, the scanning time and the rotation time. Since the amount of contrast agent used can be reduced by reducing the tube voltage, in the embodiment of the present application, from the reference protocol and the multiple groups of recommended protocols, the protocol with the minimum X-ray radiation dose applied to the scanned object is selected as the target protocol, which can effectively reduce the contrast agent dose while ensuring the image quality, so that the effectiveness and safety of the patient's enhanced examination are further improved. Moreover, the multiple groups of recommended protocols are determined according to the scanning parameter information of the scanning device, which can make the determined target protocol more targeted.

[0089] In one embodiment, the scanning parameter information also includes a reference value; based on the scanning parameter information of the scanning device, multiple groups of recommended protocols are obtained, including: for each preset scanning length, the scanning time is determined according to the scanning length, the reference value, the scanning pitch and the rotation time; the product result of the reference maximum tube current exposure, the scanning pitch and the scanning time is obtained, and the ratio of the product result to the rotation time is used as the recommended maximum tube current exposure; based on the reference minimum tube voltage and each recommended maximum tube current exposure, each recommended minimum tube voltage that meets the contrast-to-noise ratio requirement is determined; each recommended minimum tube voltage and the corresponding recommended maximum tube current exposure are used as each recommended protocol.

[0090] In this embodiment, multiple scanning lengths can be determined based on different size information of the target scanning part, that is, multiple different scanning lengths can be preset. The scanning time is obtained, where L is the scanning length, Z is the reference value, RT is the rotation time, and P is the scanning pitch.

[0091] Further, according to The recommended maximum tube current exposure b is obtained, wherein b' is the reference maximum tube current exposure.

[0092] Since the same scanning part of each patient is different, the recommended maximum tube current exposure may be greater than the reference maximum tube current exposure, or may be less than the reference maximum tube current exposure, or may be equal to the reference maximum tube current exposure.

[0093] In a possible implementation, in an embodiment of the present application, since the tube voltage and the tube current exposure will affect the attenuation coefficient of the rays emitted by the tube, thereby affecting the CT value in the image to be reconstructed, a first contrast-to-noise ratio is determined based on the CT value in the image to be reconstructed, and if the first contrast-to-noise ratio is greater than the preset noise ratio, the reference minimum tube voltage is used as the recommended minimum tube voltage. If the first contrast-to-noise ratio is less than or equal to the preset noise ratio, the reference minimum tube voltage is increased to obtain multiple candidate tube voltages, and multiple second contrast-to-noise ratios are determined based on the multiple candidate tube voltages and the recommended maximum tube current exposure, and a second contrast-to-noise ratio greater than the preset noise ratio is selected from the second contrast-to-noise ratios, and the lowest candidate tube voltage among the second contrast-to-noise ratios greater than the preset noise ratio is used as the recommended minimum tube voltage. The recommended minimum tube voltage and the corresponding recommended maximum tube current exposure are used as a set of recommended protocols.

[0094] In a possible implementation, for each recommended maximum tube current exposure, when the first contrast-to-noise ratio is less than or equal to the preset noise ratio, the reference minimum tube voltage may be gradually increased to obtain a candidate tube voltage, and the corresponding second contrast-to-noise ratio may be determined based on the candidate tube voltage and the recommended maximum tube current exposure, and if the second contrast-to-noise ratio is greater than the preset noise ratio, the candidate tube voltage may be used as the recommended minimum tube voltage. If the second contrast-to-noise ratio is less than or equal to the preset noise ratio, the candidate tube voltage may be used as the reference minimum tube voltage, and the above steps may be executed again until the second contrast-to-noise ratio is greater than the preset noise ratio, and the candidate tube voltage corresponding to the most recent second contrast-to-noise ratio greater than the preset noise ratio may be used as the recommended minimum tube voltage, and the recommended minimum tube voltage and the corresponding recommended maximum tube current exposure may be used as a set of recommended protocols.

[0095] In an embodiment of the present application, for each preset scanning length, the scanning time is determined according to the scanning length, the reference value, the scanning pitch and the rotation time, the product result of the reference maximum tube current exposure, the scanning pitch and the scanning time is obtained, and the ratio of the product result to the rotation time is used as the recommended maximum tube current exposure, and according to the reference minimum tube voltage and the recommended maximum tube current exposure, the recommended minimum tube voltages that meet the contrast-to-noise ratio requirements are determined, and the recommended minimum tube voltages and the corresponding recommended maximum tube current exposures are used as recommended protocols. The embodiment of the present application takes into account the differences in the same scanning part on different patients, and determines multiple recommended protocols based on the difference information, which lays a foundation for determining a target protocol that meets the scanning object from the reference protocol and multiple recommended protocols, and improves the accuracy of determining the target protocol.

[0096] FIG3 is a flow chart of a method for determining a target contrast agent dose in an embodiment. As shown in FIG3 , the embodiment of the present application relates to a possible implementation method of determining a target contrast agent dose according to a target protocol and a preset contrast agent concentration, including the following steps:

[0097] S301, determining an initial contrast agent dose according to a target minimum tube voltage, a target maximum tube current exposure, and a contrast agent concentration.

[0098] In the embodiment of the present application, the specific implementation method can refer to the above S204.

[0099] S302, determining a weight coefficient based on a target contrast-to-noise ratio in a reference reconstructed image; the reference reconstructed image is obtained by reconstructing reference projection data using an image reconstruction algorithm that meets image enhancement requirements, and the reference projection data is data simulated and collected under a target minimum tube voltage and a target maximum tube current exposure.

[0100] In the embodiment of the present application, according to the analysis in S204 above, it can be known that the reference projection data of the scanned part of the scanned object can be simulated and collected based on the target minimum tube voltage and the target maximum tube current exposure, and the reference projection data can be reconstructed using an image reconstruction algorithm to obtain a reference reconstructed image. The CT value in the reference reconstructed image is obtained, the image contrast and image noise value of the reference reconstructed image are determined based on the CT value, the target contrast-to-noise ratio is determined based on the image contrast and the image noise value, and the target contrast-to-noise ratio is used as a weight coefficient.

[0101] In a possible implementation, after obtaining the target contrast-to-noise ratio, the target contrast-to-noise ratio may be adjusted, and the adjusted target contrast-to-noise ratio may be used as a weight coefficient.

[0102] Optionally, the image reconstruction algorithm that meets the image enhancement requirements may be the image reconstruction algorithm required when the contrast of the image to be reconstructed corresponding to the target minimum tube voltage is different from the contrast of the image to be reconstructed corresponding to the reference minimum tube voltage, that is, the image enhancement degree is different when the contrast of the image to be reconstructed is different and / or the contrast to be achieved is different. When the target minimum tube voltage is closer to the reference minimum tube voltage, the contrast enhancement degree is smaller.

[0103] Optionally, the image reconstruction algorithm may be Karl iteration technique, artificial intelligence iterative reconstruction algorithm (AIIR), filtered back projection (FBP) reconstruction, etc. Different image reconstruction algorithms have different reconstruction algorithm levels. When the image enhancement degree is different, different image reconstruction algorithms are required. The higher the image reconstruction algorithm level, the smaller the weight coefficient, that is, the smaller the image enhancement degree, the higher the image reconstruction algorithm level, and the smaller the weight coefficient.

[0104] S303, correcting the initial contrast agent dose based on the weight coefficient to obtain a target contrast agent dose.

[0105] In the embodiment of the present application, the weight coefficient and the initial contrast agent dose can be multiplied to obtain the target contrast agent dose. As shown in Table 1, Table 1 is the target contrast agent dose (target body mass index is in the body mass index interval) obtained based on the target minimum tube voltage, the target maximum tube current exposure, the contrast agent concentration and the image reconstruction algorithm.

[0106] Table 1

[0107]

[0108] Taking Table 1 above as an example, when the target minimum tube voltage is 100 kV, the target maximum tube current exposure is 200 mAs, the contrast agent concentration is 350 mgI / ml, and the weight coefficient is 0.79, the target contrast agent dose is (100*200 / 350)*0.79=45.

[0109] In an embodiment of the present application, an initial contrast agent dose is determined according to a target minimum tube voltage, a target maximum tube current exposure, and a contrast agent concentration, a weight coefficient is determined based on a CT value in a reference reconstructed image, and the initial contrast agent dose is corrected based on the weight coefficient to obtain a target contrast agent dose. In an embodiment of the present application, when the contrast agent dose is determined by the target minimum tube voltage and the target maximum tube current exposure, the contrast of the image to be reconstructed can be further enhanced in combination with an image reconstruction algorithm, so that the same image quality as that at the reference minimum tube voltage or any tube voltage lower than the target minimum tube voltage can be achieved at a lower contrast agent dose.

[0110] In one embodiment, the method further includes: determining an image noise value and an image contrast based on a CT value in a reference reconstructed image; and using a ratio of the image contrast to the image noise value as a target contrast-to-noise ratio.

[0111] In the embodiment of the present application, the standard deviation can be calculated based on the CT value, and the standard deviation is used as the image noise value. In the reference reconstructed image, a suitable area of ​​uniform tissue is selected as the region of interest, the CT value in the selected region of interest is averaged, the non-interested region adjacent to the region of interest is calculated, the average CT value of the non-interested region is obtained, and the image contrast is determined based on the two average values.

[0112] Furthermore, the target contrast agent dose n1 can be expressed as:

[0113] ,

[0114] Among them, e is the image contrast and f is the image noise value.

[0115] In an embodiment of the present application, the image noise value and the image contrast are determined based on the CT value in the reference reconstructed image; the ratio of the image contrast to the image noise value is used as the target contrast-to-noise ratio, so that the weight coefficient determined based on the target contrast-to-noise ratio is more in line with the problem of reduced contrast of the image to be reconstructed caused by the target minimum tube voltage, thereby laying a foundation for subsequently determining the target contrast agent dose based on the weight coefficient.

[0116] FIG4 is a flow chart of a method for determining a target minimum tube voltage in an embodiment. As shown in FIG4 , the embodiment of the present application relates to a possible implementation method of determining each recommended minimum tube voltage that meets the contrast-to-noise ratio requirement based on a reference minimum tube voltage and each recommended maximum tube current exposure, including the following steps:

[0117] S401 , for each recommended maximum tube current exposure, determine a first contrast-to-noise ratio according to a reference minimum tube voltage and a recommended maximum tube current exposure.

[0118] In the embodiment of the present application, since the tube voltage and the tube current exposure affect the attenuation coefficient of the tube, thereby affecting the CT value of the image to be reconstructed, the candidate image noise value and the candidate image contrast can be determined according to the CT value of the image to be reconstructed under the reference minimum tube voltage and the recommended maximum tube current exposure, and the first contrast-to-noise ratio can be determined based on the candidate image noise value and the candidate image contrast.

[0119] S402: If the first contrast-to-noise ratio is greater than the preset noise ratio, it is determined that the first contrast-to-noise ratio meets the contrast-to-noise ratio requirement, and the reference minimum tube voltage is used as the recommended minimum tube voltage.

[0120] In the embodiment of the present application, if the first contrast-to-noise ratio is greater than the preset noise ratio, the reference minimum tube voltage meets the requirements, and the reference minimum tube voltage can be used as the recommended minimum tube voltage.

[0121] S403: If the first contrast-to-noise ratio is less than or equal to the preset noise ratio, the reference minimum tube voltage is increased to obtain a plurality of candidate tube voltages.

[0122] In the embodiment of the present application, if the first contrast-to-noise ratio is less than or equal to the preset noise ratio, the reference tube voltage may be increased based on a preset step size to obtain a plurality of candidate tube voltages.

[0123] S404, determining a plurality of second contrast-to-noise ratios based on a plurality of candidate tube voltages and a recommended maximum tube current exposure.

[0124] In the embodiment of the present application, according to the method shown in S401 above, the corresponding second contrast-to-noise ratio is determined based on each candidate tube voltage and the recommended maximum tube current exposure, and the second contrast-to-noise ratios corresponding to the plurality of candidate tube voltages are obtained.

[0125] S405: Determine a second contrast-to-noise ratio that is greater than a preset noise ratio as a target contrast-to-noise ratio.

[0126] In the embodiment of the present application, a second contrast-to-noise ratio greater than a preset noise ratio is determined from a plurality of second contrast-to-noise ratios, and the second contrast-to-noise ratio greater than the preset noise ratio is used as a target contrast-to-noise ratio. For example, the candidate tube voltage includes 10 tube voltages, which correspond to 10 second contrast-to-noise ratios respectively, among which there are 4 second contrast-to-noise ratios greater than the preset noise ratio, and these 4 second contrast-to-noise ratios are used as target contrast-to-noise ratios.

[0127] S406: taking the lowest candidate tube voltage corresponding to the target contrast-to-noise ratio as the recommended minimum tube voltage.

[0128] In the embodiment of the present application, the lowest candidate tube voltage corresponding to the target contrast-to-noise ratio is used as the recommended minimum tube voltage. For example, there are 4 target contrast-to-noise ratios, corresponding to 4 candidate tube voltages respectively, and the lowest candidate tube voltage among the 4 candidate tube voltages is used as the recommended minimum tube voltage.

[0129] In the embodiment of the present application, for each recommended maximum tube current exposure, a first contrast-to-noise ratio is determined according to a reference minimum tube voltage and the recommended maximum tube current exposure; if the first contrast-to-noise ratio is greater than a preset noise ratio, it is determined that the first contrast-to-noise ratio meets the contrast-to-noise ratio requirement, and the reference minimum tube voltage is used as the recommended minimum tube voltage; if the first contrast-to-noise ratio is less than or equal to the preset noise ratio, the reference minimum tube voltage is increased to obtain a plurality of candidate tube voltages; a second contrast-to-noise ratio greater than the preset noise ratio is determined as a target contrast-to-noise ratio; the lowest candidate tube voltage corresponding to the target contrast-to-noise ratio is used as the recommended minimum tube voltage, thereby improving the accuracy of obtaining the recommended minimum tube voltage.

[0130] In one embodiment, determining a reference protocol of a scanning device according to a scanning object includes:

[0131] A reference minimum tube voltage is determined based on a target body mass index of the scanned object and a first preset correspondence; the first preset correspondence includes a correspondence between different body mass index intervals and different minimum tube voltages; a reference maximum tube current exposure is determined based on a target scanning part of the scanned object and a second preset correspondence; the second preset correspondence includes a correspondence between different scanning parts and different maximum tube current exposures.

[0132] In the embodiment of the present application, the first preset correspondence relationship and the target body mass index can be matched, and the target scanning part can be matched with the second preset correspondence relationship to obtain the reference minimum tube voltage and the reference maximum tube current exposure. The first preset correspondence relationship and the second preset correspondence relationship can be combined as shown in Table 2, that is, when the target scanning part is scanning part 1, scanning part 3 or scanning part 4, the reference maximum tube current exposure is 200mAs, and when the target scanning part is scanning part 2, the reference maximum tube current exposure is 300mAs. When the target body mass index is less than or equal to 18.5, the reference minimum tube voltage is 60kV, when the target body mass index is greater than 18.5 and less than or equal to 24, the reference minimum tube voltage is 70kV, when the target body mass index is greater than 24 and less than or equal to 28, the reference minimum tube voltage is 80kV, and when the target body mass index is greater than 28 and less than or equal to 40, the reference minimum tube voltage is 100kV.

[0133] Table 2

[0134]

[0135] Based on the corresponding relationship shown in Table 2 above, assuming that the target scanning part of the scanned object is scanning part 1, the reference maximum tube current exposure is 200 mAs, the target body mass index is 18, and the reference minimum tube voltage is 60 kV.

[0136] In the embodiment of the present application, a reference minimum tube voltage is determined based on a target body mass index of the scanned object and a first preset correspondence, and an initial maximum tube current exposure is determined based on a target scanning part of the scanned object and a second preset correspondence, thereby improving the efficiency of determining the reference minimum tube voltage and the reference maximum tube current exposure.

[0137] FIG. 5 is a flow chart of a method for determining a contrast agent dosage in another embodiment, and FIG. 6 is a flow chart of a method for determining a contrast agent dosage in another embodiment. As shown in FIG. 5 and FIG. 6 , the method includes the following steps:

[0138] S501, determining a reference minimum tube voltage according to a target body mass index of a scanned object and a first preset corresponding relationship; the first preset corresponding relationship includes a corresponding relationship between different body mass index intervals and different minimum tube voltages;

[0139] S502, determining a reference maximum tube current exposure amount according to a target scanning part of the scanning object and a second preset corresponding relationship; the second preset corresponding relationship includes a corresponding relationship between different scanning parts and different maximum tube current exposure amounts;

[0140] S503, for each preset scanning length, determining the scanning time according to the scanning length, the alignment value, the scanning pitch and the rotation time;

[0141] S504, obtaining a product result of a reference maximum tube current exposure, a scanning pitch, and a scanning time, and taking a ratio of the product result to the rotation time as a recommended maximum tube current exposure;

[0142] S505, for each recommended maximum tube current exposure, determining a first contrast-to-noise ratio according to a reference minimum tube voltage and a recommended maximum tube current exposure;

[0143] S506, if the first contrast-to-noise ratio is greater than the preset noise ratio, determining that the first contrast-to-noise ratio meets the contrast-to-noise ratio requirement, and using the reference minimum tube voltage as the recommended minimum tube voltage;

[0144] S507, if the first contrast-to-noise ratio is less than or equal to the preset noise ratio, increasing the reference minimum tube voltage to obtain a plurality of candidate tube voltages;

[0145] S508, determining a plurality of second contrast-to-noise ratios based on a plurality of candidate tube voltages and a recommended maximum tube current exposure;

[0146] S509, determining a second contrast-to-noise ratio greater than a preset noise ratio as a target contrast-to-noise ratio;

[0147] S510, taking the lowest candidate tube voltage corresponding to the target contrast-to-noise ratio as the recommended minimum tube voltage;

[0148] S511, taking each recommended minimum tube voltage and the corresponding recommended maximum tube current exposure as each recommended protocol;

[0149] S512, selecting a protocol with the smallest X-ray radiation dose applied to the scanned object from the reference protocol and the plurality of groups of recommended protocols as a target protocol; the target protocol includes a target minimum tube voltage and a target maximum tube current exposure;

[0150] S513, determining an initial contrast agent dose according to a target minimum tube voltage, a target maximum tube current exposure, and a contrast agent concentration;

[0151] S514, determining a weight coefficient based on a target contrast-to-noise ratio in a reference reconstructed image; the reference reconstructed image is obtained by reconstructing reference projection data using an image reconstruction algorithm that meets image enhancement requirements, and the reference projection data is data simulated and collected under a target minimum tube voltage and a target maximum tube current exposure;

[0152] S515, correcting the initial contrast agent dose based on the weight coefficient to obtain a target contrast agent dose.

[0153] Since the amount of contrast agent used can be reduced by lowering the tube voltage, in the embodiment of the present application, the protocol with the smallest X-ray radiation dose applied to the scanned object is selected as the target protocol from the reference protocol and multiple groups of recommended protocols, which can effectively reduce the dose of contrast agent while ensuring image quality, thereby further improving the effectiveness and safety of enhanced examinations for patients. Moreover, multiple groups of recommended protocols are determined based on the scanning parameter information of the scanning device, which can make the determined target protocol more targeted.

[0154] It should be understood that, although the various steps in the flowcharts involved in the above-mentioned embodiments are displayed in sequence according to the indication of the arrows, these steps are not necessarily executed in sequence according to the order indicated by the arrows. Unless there is a clear explanation in this article, the execution of these steps does not have a strict order restriction, and these steps can be executed in other orders. Moreover, at least a part of the steps in the flowcharts involved in the above-mentioned embodiments can include multiple steps or multiple stages, and these steps or stages are not necessarily executed at the same time, but can be executed at different times, and the execution order of these steps or stages is not necessarily to be carried out in sequence, but can be executed in turn or alternately with other steps or at least a part of the steps or stages in other steps.

[0155] Based on the same inventive concept, the embodiment of the present application also provides a contrast agent dosage determination device for implementing the contrast agent dosage determination method involved above. The implementation scheme for solving the problem provided by the device is similar to the implementation scheme recorded in the above method, so the specific limitations in one or more contrast agent dosage determination device embodiments provided below can refer to the limitations of the contrast agent dosage determination method above, and will not be repeated here.

[0156] In an exemplary embodiment, as shown in FIG7 , a contrast agent dosage determination device is provided, comprising: a first determination module 11, an acquisition module 12, a selection module 13, and a second determination module 14, wherein:

[0157] The first determination module 11 is used to determine a reference protocol of the scanning device according to the scanning object; the reference protocol includes a reference minimum tube voltage and a reference maximum tube current exposure of the tube in the scanning device;

[0158] The acquisition module 12 is used to acquire multiple groups of recommended protocols based on the scanning parameter information of the scanning device; each recommended protocol includes a recommended minimum tube voltage and a recommended maximum tube current exposure of the tube, and the contrast-to-noise ratio of the reconstructed image obtained under each recommended protocol meets the requirements; the scanning parameter information includes at least one of a scanning pitch, a scanning time, and a rotation time;

[0159] A selection module 13, for selecting a protocol with the smallest X-ray radiation dose applied to the scanned object from the reference protocol and the plurality of groups of recommended protocols as a target protocol;

[0160] The second determination module 14 is used to determine a target contrast agent dose according to a target protocol and a preset contrast agent concentration.

[0161] In one embodiment, the acquisition module 12 is specifically used to determine the scanning time for each preset scanning length according to the scanning length, the alignment value, the scanning pitch and the rotation time; obtain the product result of the reference maximum tube current exposure, the scanning pitch and the scanning time, and use the ratio of the product result to the rotation time as the recommended maximum tube current exposure; determine each recommended minimum tube voltage that meets the contrast-to-noise ratio requirement according to the reference minimum tube voltage and each recommended maximum tube current exposure; and use each recommended minimum tube voltage and the corresponding recommended maximum tube current exposure as each recommended protocol.

[0162] In one embodiment, the second determination module 14 is specifically used to determine the initial contrast agent dose according to the target minimum tube voltage, the target maximum tube current exposure and the contrast agent concentration; determine the weight coefficient based on the target contrast-to-noise ratio in the reference reconstructed image; the reference reconstructed image is obtained by reconstructing the reference projection data using an image reconstruction algorithm that meets the image enhancement requirements, and the reference projection data is data simulated and collected under the target minimum tube voltage and the target maximum tube current exposure; the initial contrast agent dose is corrected based on the weight coefficient to obtain the target contrast agent dose.

[0163] In one embodiment, the second determination module 14 is specifically configured to determine the image noise value and the image contrast based on the CT value in the reference reconstructed image; and use the ratio of the image contrast to the image noise value as the target contrast-to-noise ratio.

[0164] In one embodiment, the acquisition module 12 is specifically used to determine a first contrast-to-noise ratio for each recommended maximum tube current exposure according to a reference minimum tube voltage and the recommended maximum tube current exposure; if the first contrast-to-noise ratio is greater than a preset noise ratio, it is determined that the first contrast-to-noise ratio meets the contrast-to-noise ratio requirement, and the reference minimum tube voltage is used as the recommended minimum tube voltage.

[0165] In one embodiment, the acquisition module 12 is specifically configured to increase the reference minimum tube voltage to obtain a plurality of candidate tube voltages if the first contrast-to-noise ratio is less than or equal to a preset noise ratio; determine a plurality of second contrast-to-noise ratios based on the plurality of candidate tube voltages and the recommended maximum tube current exposure; determine a second contrast-to-noise ratio greater than the preset noise ratio as a target contrast-to-noise ratio; and use the lowest candidate tube voltage corresponding to the target contrast-to-noise ratio as the recommended minimum tube voltage.

[0166] In one embodiment, the first determination module 11 is specifically used to determine a reference minimum tube voltage according to a target body mass index of the scanned object and a first preset correspondence relationship; the first preset correspondence relationship includes a correspondence between different body mass index intervals and different minimum tube voltages; and to determine a reference maximum tube current exposure according to a target scanning part of the scanned object and a second preset correspondence relationship; the second preset correspondence relationship includes a correspondence between different scanning parts and different maximum tube current exposures.

[0167] Each module in the above contrast agent dosage determination device can be implemented in whole or in part by software, hardware, or a combination thereof. Each module can be embedded in or independent of a processor in a computer device in the form of hardware, or can be stored in a memory in a computer device in the form of software, so that the processor can call and execute operations corresponding to each module.

[0168] In an exemplary embodiment, a computer device is provided, including a memory and a processor, wherein a computer program is stored in the memory, and the processor implements the steps of any of the above method embodiments when executing the computer program.

[0169] In one embodiment, a computer-readable storage medium is provided, on which a computer program is stored. When the computer program is executed by a processor, the steps of any of the above method embodiments are implemented.

[0170] In one embodiment, a computer program product is provided, including a computer program, which implements the steps of any of the above method embodiments when executed by a processor.

[0171] It should be noted that the user information (including but not limited to user device information, user personal information, etc.) and data (including but not limited to data used for analysis, stored data, displayed data, etc.) involved in this application are all information and data authorized by the user or fully authorized by all parties, and the collection, use and processing of relevant data must comply with relevant regulations.

[0172] A person of ordinary skill in the art can understand that all or part of the processes in the above-mentioned embodiment method can be completed by instructing the relevant hardware through a computer program, and the computer program can be stored in a non-volatile computer-readable storage medium. When the computer program is executed, it can include the processes of the embodiments of the above-mentioned methods. Among them, any reference to the memory, database or other medium used in the embodiments provided in the present application can include at least one of non-volatile memory and volatile memory. Non-volatile memory can include read-only memory (ROM), magnetic tape, floppy disk, flash memory, optical memory, high-density embedded non-volatile memory, resistive random access memory (ReRAM), magnetic random access memory (MRAM), ferroelectric random access memory (FRAM), phase change memory (PCM), graphene memory, etc. Volatile memory can include random access memory (RAM) or external cache memory, etc. As an illustration and not limitation, RAM can be in various forms, such as static random access memory (SRAM) or dynamic random access memory (DRAM). The database involved in each embodiment provided in this application may include at least one of a relational database and a non-relational database. Non-relational databases may include distributed databases based on blockchains, etc., but are not limited to this. The processor involved in each embodiment provided in this application may be a general-purpose processor, a central processing unit, a graphics processor, a digital signal processor, a programmable logic device, a data processing logic device based on quantum computing, an artificial intelligence (AI) processor, etc., but are not limited to this.

[0173] The technical features of the above embodiments may be combined arbitrarily. To make the description concise, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this application.

[0174] The above-described embodiments only express several implementation methods of the present application, and the descriptions thereof are relatively specific and detailed, but they cannot be understood as limiting the scope of the present application. It should be pointed out that, for a person of ordinary skill in the art, several variations and improvements can be made without departing from the concept of the present application, and these all belong to the protection scope of the present application. Therefore, the protection scope of the present application shall be subject to the attached claims.

Claims

1. A method for determining a contrast agent dose, characterized in that: The method comprises: Determine a reference protocol of the scanning device according to the scanning object; the reference protocol includes a reference minimum tube voltage and a reference maximum tube current exposure of the tube in the scanning device; Based on the scanning parameter information of the scanning device, a plurality of groups of recommended protocols are obtained; each of the recommended protocols includes a recommended minimum tube voltage and a recommended maximum tube current exposure of the tube, and the contrast-to-noise ratio of the reconstructed image obtained under each of the recommended protocols meets the requirements; the scanning parameter information includes at least one of a scanning pitch, a scanning time, and a rotation time; Selecting, from the reference protocol and the plurality of groups of recommended protocols, a protocol that minimizes the X-ray radiation dose applied to the scanned object as a target protocol; A target contrast agent dose is determined according to the target protocol and a preset contrast agent concentration.

2. The method according to claim 1, characterized in that The scanning parameter information also includes a standard value; the acquiring multiple groups of recommended protocols based on the scanning parameter information of the scanning device includes: For each preset scanning length, determining the scanning time according to the scanning length, the alignment value, the scanning pitch and the rotation time; Obtaining a product of the reference maximum tube current exposure, the scanning pitch and the scanning time, and taking a ratio of the product to the rotation time as the recommended maximum tube current exposure; Determining each of the recommended minimum tube voltages that meets the contrast-to-noise ratio requirement according to the reference minimum tube voltage and each of the recommended maximum tube current exposures; The recommended minimum tube voltage and the corresponding recommended maximum tube current exposure are taken as the recommended protocols.

3. The method according to claim 1, characterized in that The target protocol includes a target minimum tube voltage and a target maximum tube current exposure; Determining a target contrast agent dose according to the target protocol and a preset contrast agent concentration includes: determining an initial contrast agent dose according to the target minimum tube voltage, the target maximum tube current exposure, and the contrast agent concentration; Determine the weight coefficient based on the target contrast-to-noise ratio in the reference reconstructed image; the reference reconstructed image is obtained by reconstructing the reference projection data using an image reconstruction algorithm that meets the image enhancement requirements, and the reference projection data is data simulated and collected under the exposure amount of the target minimum tube voltage and the target maximum tube current; The initial contrast agent dose is corrected based on the weight coefficient to obtain the target contrast agent dose.

4. The method according to claim 3, characterized in that The method further comprises: determining an image noise value and an image contrast based on the CT value in the reference reconstructed image; The ratio of the image contrast to the image noise value is used as the target contrast-to-noise ratio.

5. The method according to claim 2, characterized in that: Determining each of the recommended minimum tube voltages that meets the contrast-to-noise ratio requirement according to the reference minimum tube voltage and each of the recommended maximum tube current exposures includes: For each of the recommended maximum tube current exposures, determining a first contrast-to-noise ratio according to the reference minimum tube voltage and the recommended maximum tube current exposure; If the first contrast-to-noise ratio is greater than a preset noise ratio, it is determined that the first contrast-to-noise ratio meets the contrast-to-noise ratio requirement, and the reference minimum tube voltage is used as the recommended minimum tube voltage.

6. The method according to claim 5, characterized in that The method further comprises: If the first contrast-to-noise ratio is less than or equal to the preset noise ratio, increasing the reference minimum tube voltage to obtain a plurality of candidate tube voltages; determining a plurality of second contrast-to-noise ratios based on the plurality of candidate tube voltages and the recommended maximum tube current exposure; determining a second contrast-to-noise ratio greater than the preset noise ratio as a target contrast-to-noise ratio; The lowest candidate tube voltage corresponding to the target contrast-to-noise ratio is used as the recommended minimum tube voltage.

7. The method according to claim 1, characterized in that The step of determining a reference protocol of a scanning device according to a scanning object comprises: Determining a reference minimum tube voltage according to a target body mass index of the scanned object and a first preset corresponding relationship; the first preset corresponding relationship includes a corresponding relationship between different body mass index intervals and different minimum tube voltages; A reference maximum tube current exposure is determined according to the target scanning part of the scanning object and a second preset corresponding relationship; the second preset corresponding relationship includes a corresponding relationship between different scanning parts and different maximum tube current exposure amounts.

8. A contrast agent dosage determination device, characterized in that: The device comprises: A first determination module is used to determine a reference protocol of a scanning device according to a scanning object; the reference protocol includes a reference minimum tube voltage and a reference maximum tube current exposure of a tube in the scanning device; an acquisition module, configured to acquire multiple groups of recommended protocols based on the scanning parameter information of the scanning device; each of the recommended protocols includes a recommended minimum tube voltage and a recommended maximum tube current exposure of the tube, and the contrast-to-noise ratio of the reconstructed image obtained under each of the recommended protocols meets the requirements; the scanning parameter information includes at least one of a scanning pitch, a scanning time, and a rotation time; A selection module, configured to select, from the reference protocol and the plurality of groups of recommended protocols, a protocol with a minimum X-ray radiation dose applied to the scanned object as a target protocol; The second determination module is used to determine a target contrast agent dose according to the target protocol and a preset contrast agent concentration.

9. A computer device comprising a memory and a processor, wherein the memory stores a computer program, wherein: When the processor executes the computer program, the steps of the method according to any one of claims 1 to 7 are implemented.

10. A computer-readable storage medium having a computer program stored thereon, characterized in that: When the computer program is executed by a processor, the steps of the method according to any one of claims 1 to 7 are implemented.

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