Lateral wormwood herb lotion as well as preparation method and application thereof

Abstract

The invention provides a Chinese arborvitae twig and folium artemisiae argyi lotion and a preparation method and application thereof, and relates to the technical field of alopecia prevention, the Chinese arborvitae twig and folium artemisiae argyi lotion is prepared from the following traditional Chinese medicines: Chinese arborvitae twig, rhizoma drynariae, folium artemisiae argyi, chrysanthemum, mint, schizonepeta, divaricate saposhnikovia root, ligusticum, wrinkled gianthyssop herb, rhizoma nardostachyos, fructus viticis, radix polygoni multiflori preparata and garden balsam stem, and the Chinese arborvitae twig and folium artemisiae argyi lotion is prepared by soaking and decocting the traditional Chinese medicines in distilled water and filtering out traditional According to the prepared folium artemisiae argyi lotion, the medicinal materials are reasonably matched, the traditional Chinese medicinal materials are combined together according to the compatibility of monarch, minister, assistant and guide, the effects of stimulating hair follicle conversion, inhibiting the activity of 5-alpha reductase, adjusting the scalp microenvironment, relieving scalp greasiness and the like are achieved, heat clearing, dampness eliminating, liver and kidney nourishing and blood cooling and nourishing can be achieved, meanwhile, blood circulation promoting and collateral dredging can be achieved, and the effect of removing blood stasis is achieved. The traditional Chinese medicine composition has a good effect on androgen alopecia, alopecia areata, scalp seborrheic dermatitis or scalp psoriasis with symptoms such as alopecia, more oily hair, scalp desquamation or itching and the like.

Description

Technical Field

[0001] The invention relates to the technical field of anti-hair loss, and in particular to a side moxa lotion and a preparation method and application thereof. Background Art

[0002] Androgenic alopecia (AGA), also known as seborrheic alopecia, is a progressive hair follicle miniaturization hair loss disease, characterized by the process of hair becoming increasingly vellus, falling out and becoming sparse. The patient's hair loss pattern is relatively typical. In men, it is mainly manifested by the receding hairline and / or the progressive thinning and reduction of hair on the top of the head. In women, it is mainly manifested by diffuse thinning of the hair on the top of the head, accompanied by symptoms such as greasy scalp, increased dandruff, and itchy scalp.

[0003] AGA is a common clinical disease in dermatology and the most common cause of non-scarring alopecia. Epidemiological data show that about 80% of men and 50% of women have AGA problems throughout their lives, and the incidence rates vary significantly in different countries and regions. The incidence rate of AGA in my country is 21.3% for men and 6.0% for women, with a total number of 130-140 million people. With the development of modern society and the increase in life pressure, the incidence rate of AGA is still increasing year by year, and it is showing a trend of younger age. Studies have found that 14.1% of adolescents have early signs of AGA, and the proportion of AGA in adolescents aged 12 to 19 years old with hair loss is as high as 42%, with the average age of onset of males and females being 13.7 and 10.8 years old, respectively. Although AGA does not directly threaten physical health, it affects the patient's appearance, brings varying degrees of negative impact to the patient, and can cause psychological diseases such as depression and anxiety. The existing treatment methods for AGA are limited, effective drugs are in short supply, and the efficacy is unsatisfactory. In addition, there are many drug contraindications and side effects. It is difficult to take into account the needs of special groups of patients such as children, adolescents, women and patients with cardiovascular events. This is a bottleneck problem in the current clinical practice. Therefore, it is necessary to continue to explore safe and effective treatment methods for AGA. Although modern medicine has not yet fully clarified the etiology and molecular mechanism of AGA, traditional Chinese medicine has a long history of research on the causes of hair loss and is relatively mature. Traditional Chinese medicine believes that the growth of hair requires not only sufficient kidney qi, but also the nourishment of liver blood. "The liver and kidney are of the same origin" and "hair is the rest of blood", so liver and kidney deficiency is the internal cause of this disease. If the liver and kidney are deficient for a long time, the yin blood will be deficient, and the virtual heat will rise, causing the head to heat up and cause wind. The internal wind and external wind will combine with damp heat, blood stasis, etc. to fight in the head, eroding the hair roots, thereby causing hair loss, accompanied by symptoms such as itchy and greasy scalp, and desquamation. Under the guidance of this theory, the research and development of traditional Chinese medicine anti-hair loss products focuses on improving the growth environment of hair by regulating the internal balance of the human body. Natural plant extracts are widely used due to their potential in promoting hair growth and low risk of side effects. These ingredients include, but are not limited to, biotin (vitamin H), zinc, iron, protein, amino acids, antioxidants, and specific plant extracts (such as ginger, Polygonum multiflorum, Platycladus orientalis, etc.), which are believed to improve the scalp environment, promote blood circulation, and enhance hair follicle vitality. There are some Chinese medicine topical preparations on the market, which have certain effects, but their efficacy still cannot satisfy patients.

[0004] Therefore, finding new, safe and effective drugs for the treatment of AGA has important social and clinical significance. Summary of the invention

[0005] In order to solve the problems of the prior art, the present invention adopts a distilled water soaking and decoction method to prepare a side moxa lotion by reasonably matching medicinal materials, which can gently nourish the liver and kidneys while clearing away heat and dampness, promote blood circulation and dredge meridians in the process of cooling blood and nourishing blood, can significantly promote hair growth, and can improve symptoms such as scalp itching, oiliness, and desquamation. It has a fast clinical onset, a long duration of efficacy, is easy to use, and has low skin irritation. Specifically, the technical solution of the present invention includes the following contents:

[0006] One of the purposes of the present invention is to provide a side wormwood wash, which comprises the following traditional Chinese medicines: Platycladus orientalis leaves, Drynaria fortunei, wormwood leaves, chrysanthemum, mint, Nepeta tenuifolia, Saposhnikovia divaricata, Ligusticum chuanxiong, Patchouli, Nardostachys grandiflora, Vitex rotundifolia, processed Polygonum multiflorum and Herba speranskiae radix et Rhizoma.

[0007] Furthermore, the mass ratio of Platycladus orientalis leaves: Drynaria fortunei: Artemisia argyi: Chrysanthemum: Menthus alba: Nepeta tenuifolia: Saposhnikovia divaricata: Ligusticum chuanxiong: Patchouli grandiflorum: Nardostachys chinensis: Vitex rotundus: Prepared Polygonum multiflorum: Herba speranskiae radix et Rhizoma is 10-20:7-15:3-6:3-6:3-6:3-6:3-6:3-6:3-6:3-6:3-6:3-6:8-10:10-15.

[0008] Preferably, the mass ratio of Platycladus orientalis leaves: Drynaria fortunei: Artemisia argyi: Chrysanthemum: Menthus alba: Nepeta tenuifolia: Saposhnikovia divaricata: Ligusticum chuanxiong: Patchouli grandiflorum: Nardostachys chinensis: Vitex rotundifolia: Prepared Polygonum multiflorum: Herba speranskiae radix et Rhizoma is 15:10:6:6:6:6:6:6:6:6:6:6:10:15.

[0009] The second object of the present invention is to provide a method for preparing a side mugwort lotion, the preparation method comprising the following steps: preparing 10 to 20 parts by weight of Platycladus orientalis leaves, 7 to 15 parts by weight of Drynaria fortunei, 3 to 6 parts by weight of mugwort leaves, 3 to 6 parts by weight of chrysanthemum, 3 to 6 parts by weight of mint, 3 to 6 parts by weight of schizonepeta, 3 to 6 parts by weight of siler, 3 to 6 parts by weight of ligusticum chuanxiong, 3 to 6 parts by weight of Patchouli, 3 to 6 parts by weight of Nardostachys chinensis, 3 to 6 parts by weight of Vitex rotundifolia, 8 to 10 parts by weight of processed Polygonum multiflorum and 10 to 15 parts by weight of Herba schizonepetae, adding distilled water for soaking, performing a first decoction after the soaking to obtain a first mixed medicinal liquid, taking 300 to 700 parts by weight of the first mixed medicinal liquid as medicinal liquid A1, and the remaining first mixed medicinal liquid as medicinal liquid A2;

[0010] The medicinal solution A2 is mixed with water and then boiled for a second time to obtain a second mixed medicinal solution, and 300 to 700 parts by weight of the second mixed medicinal solution is taken as medicinal solution B;

[0011] The medicinal solution A1 and the medicinal solution B are mixed and then sterilized and filtered to obtain the side moxa wash.

[0012] Furthermore, the distilled water is used in an amount of 1000 parts by mass.

[0013] Furthermore, the conditions for distilled water soaking include a soaking temperature of 25 to 35° C. and a soaking time of 10 to 30 min. The distilled water soaking can pre-dissolve the active ingredients in the medicinal materials, thereby facilitating better extraction during the subsequent decoction process.

[0014] Furthermore, the conditions for the first decoction include a decoction temperature of 95-100° C. and a decoction time of 1-2 hours.

[0015] Furthermore, the conditions for the second decoction include a decoction temperature of 95-100° C. and a decoction time of 1-2 hours.

[0016] The third object of the present invention is to provide an application of a side-wormwood lotion in the treatment of hair loss, wherein the dosage form of the side-wormwood lotion is a liquid preparation.

[0017] Furthermore, the applied side moxa lotion is an external preparation.

[0018] Compared with the prior art, the present invention has the following beneficial effects:

[0019] (1) In order to achieve the purpose of preventing hair loss, the present invention formulates an empirical formula of a lateral mugwort lotion, which combines Platycladus orientalis leaves, Drynaria fortunei, mugwort leaves, chrysanthemum, mint, Nepeta tenuifolia, Saposhnikovia divaricata, Ligusticum chuanxiong, Patchouli grandiflora, Nardostachys grandiflora, Vitex rotundifolia, processed Polygonum multiflorum and Herba speranskiae radix according to the compatibility relationship of monarch, minister, assistant and envoy. Platycladus orientalis leaves have strong skin permeability and can stimulate the transition of hair follicles from the resting phase to the growth phase by activating multiple signaling pathways such as PI3K-Akt, Wnt / β-catenin and Shh / Gli-1. Drynaria fortunei can regulate the scalp microenvironment and promote the health of hair follicles. Processed Polygonum multiflorum reduces dihydrotestosterone (DHT) by inhibiting 5-α reductase. The herb can relieve greasy scalp and reduce hair loss. The herb can be synergistically combined with the medicinal materials to directly act on the scalp. It utilizes the multi-component and multi-target therapeutic induction effects of the traditional Chinese medicine to take into account the effects of warming the liver and kidney and clearing away heat and removing dampness, while promoting blood circulation and smooth meridians, strengthening the body and improving the patient's physique. It can not only promote the proliferation of hair follicle cells and hair growth, but also play a significant anti-hair loss effect. It can also improve various symptoms such as scalp itching, desquamation and greasy, etc. It has a fast clinical effect, a lasting efficacy, is easy to use, and has no irritation to the skin.

[0020] (2) For the first time, the medical institution preparation of the cerebrospinal fluid was developed to provide patients with a more convenient form of medication; for the first time, the extraction and preparation process of the cerebrospinal fluid was investigated to provide a research reference for the improvement and optimization of the subsequent preparation process.

[0021] (3) Under the guidance of the TCM pathogenesis of AGA that "yin and yang imbalance in the kidney is the root cause, and damp-heat toxicity is the symptom", combined with medication experience, the ancient prescription Hai Ai Tang was modified into Ce Ai Wash, and the ancient prescription was used for modern purposes to further verify the clinical efficacy of Ce Ai Wash in the treatment of AGA, aiming to provide new methods and means for the treatment of AGA.

[0022] (4) The side moxa wash is a modified version of the ancient prescription. It follows the ancient recipe but does not stick to it. It warms and nourishes the liver and kidneys while clearing away heat and removing dampness, and activates blood circulation while cooling and nourishing blood. It strengthens the body and eliminates evil, harmonizes yin and yang, and has a mild medicinal property. As an external prescription, the main, secondary, auxiliary and guiding drugs are properly matched, which is similar to the internal decoction. It not only treats both the symptoms and the root cause, but also has a therapeutic effect that can directly reach the diseased area, slow down hair loss, promote hair growth, and improve symptoms such as itching, scaling, and oiliness of the head skin. DETAILED DESCRIPTION

[0023] The technical solution of the present invention will be clearly and completely described below through the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative work are within the scope of protection of the present invention.

[0024] Unless otherwise specified, the raw materials and reagents used in the present invention are commercially available or can be prepared by known methods.

[0025] The present invention uses Platycladus orientalis leaf and Drynaria fortunei as the main ingredients, focusing on clearing away heat and cooling blood while taking into account promoting blood circulation and dispelling wind, and making the beard and hair black; uses Artemisia argyi, chrysanthemum, mint, Nepeta tenuifolia, Saposhnikovia divaricata, Ligusticum chuanxiong, Patchouli, Nardostachys grandiflora, and Vitex rotundifolia as the secondary ingredients, assisting the main ingredients in promoting hair growth and preventing hair loss, while playing the role of harmonizing qi and blood, dispelling wind and relieving itching; uses processed Polygonum multiflorum as the auxiliary ingredient, playing the role of nourishing essence and blood, promoting beard and hair blackening, and secondly, warming and nourishing the liver and kidneys in clearing heat and removing dampness, and balancing cold and heat; uses Radix schizonepetae as the auxiliary ingredient, guiding all the ingredients to directly reach the diseased area to play a good effect, while having the functions of warming and dispelling cold and dampness, detoxifying and relieving itching.

[0026] Embodiment 1:

[0027] Weigh 15g of Platycladus orientalis leaf, 10g of Drynaria fortunei, 6g of Artemisia argyi, 6g of Chrysanthemum, 6g of Mentha, 6g of Nepeta tenuifolia, 6g of Saposhnikovia divaricata, 6g of Ligusticum chuanxiong, 6g of Patchouli acutifolia, 6g of Nardostachys raphis, 6g of Vitex rotundifolia, 10g of Radix Polygoni Multiflori processed and 15g of Herba Scutellariae radix Polygoni Multiflori, add 1000g of distilled water, soak for 30min in a 35°C environment, pour the medicinal materials together with the soaked distilled water into a decoction pot and perform the first decoction in a 100°C environment after the soaking, the decoction time is controlled to be 2h, and after the first decoction, a first mixed medicinal liquid is obtained, 500g of the first mixed medicinal liquid is taken as medicinal liquid A1, and the remaining first mixed medicinal liquid is medicinal liquid A2. Subsequently, the medicinal liquid A2 is mixed with 1000g of distilled water, and a second decoction is performed in a 100°C environment, the decoction time is controlled to be 2h, and after the second decoction, a second mixed medicinal liquid is obtained, and 500g of the second mixed medicinal liquid is taken as medicinal liquid B. 500 g of liquid A collected after the first decoction and 500 g of liquid B collected after the second decoction were combined together, and the cephalosporin lotion was prepared by sterilizing and filtering.

[0028] Embodiment 2:

[0029] Weigh 10g of Platycladus orientalis leaf, 7g of Drynaria fortunei, 3g of Artemisia argyi, 3g of Chrysanthemum, 3g of Mentha, 3g of Nepeta tenuifolia, 3g of Saposhnikovia divaricata, 3g of Ligusticum chuanxiong, 3g of Patchouli herba, 3g of Nardostachys raphis, 3g of Vitex rotundifolia, 8g of Radix Polygoni Multiflori processed and 10g of Herba Scutellariae radix-sinensis, add 1000g of distilled water, soak for 10min in a 25°C environment, pour the medicinal materials together with the soaked distilled water into a decoction pot and decoct for the first time in a 95°C environment after the soaking, the decoction time is controlled to be 1h, and the first mixed medicinal liquid is obtained after the first decoction, 700g of the first mixed medicinal liquid is taken as medicinal liquid A1, and the remaining first mixed medicinal liquid is medicinal liquid A2. Then, the medicinal liquid A2 is mixed with 1000g of distilled water, and the second decoction is carried out in a 95°C environment, the decoction time is controlled to be 1h, and the second mixed medicinal liquid is obtained after the second decoction, and 300g of the second mixed medicinal liquid is taken as medicinal liquid B. 700 g of liquid A collected after the first decoction and 300 g of liquid B collected after the second decoction were combined together, and the cephalosporin lotion was prepared by sterilizing and filtering.

[0030] Embodiment 3:

[0031] Weigh 20g of Platycladus orientalis leaf, 15g of Drynaria fortunei, 5g of Artemisia argyi, 5g of Chrysanthemum, 5g of Mentha, 5g of Nepeta tenuifolia, 5g of Saposhnikovia divaricata, 5g of Ligusticum chuanxiong, 5g of Patchouli amomi, 5g of Nardostachys raphis, 5g of Vitex rotundifolia, 10g of Radix Polygoni Multiflori Processed and 15g of Herba Scutellariae Sinensis, add 1000g of distilled water, soak for 20min in a 30°C environment, pour the medicinal materials together with the soaked distilled water into a decoction pot and decoct for the first time in a 98°C environment after the soaking, the decoction time is controlled to be 1.5h, and the first mixed medicinal liquid is obtained after the first decoction, 400g of the first mixed medicinal liquid is taken as medicinal liquid A1, and the remaining first mixed medicinal liquid is medicinal liquid A2. Then, the medicinal liquid A2 is mixed with 1000g of distilled water, and the second decoction is carried out in a 98°C environment, the decoction time is controlled to be 1.5h, and the second mixed medicinal liquid is obtained after the second decoction, and 600g of the second mixed medicinal liquid is taken as medicinal liquid B. 400 g of liquid A collected after the first decoction and 600 g of liquid B collected after the second decoction were combined together, and the cephalosporin lotion was obtained by sterilizing and filtering.

[0032] Embodiment 4:

[0033] Weigh 20g of Platycladus orientalis leaf, 15g of Drynaria fortunei, 3g of Artemisia argyi, 3g of Chrysanthemum, 3g of Mentha, 3g of Nepeta tenuifolia, 3g of Saposhnikovia divaricata, 3g of Ligusticum chuanxiong, 3g of Patchouli herba, 3g of Nardostachys raphis, 3g of Vitex rotundifolia, 8g of Radix Polygoni Multiflori processed and 15g of Herba Scutellariae radix Polygoni Multiflori, add 1000g of distilled water, soak for 30min in a 35°C environment, pour the medicinal materials and the soaked distilled water into a decoction pot together with the soaked distilled water, decoct for the first time in a 97°C environment, the decoction time is controlled to be 1h, and after the first decoction, a first mixed medicinal liquid is obtained, 500g of the first mixed medicinal liquid is taken as medicinal liquid A1, and the remaining first mixed medicinal liquid is medicinal liquid A2. Then, the medicinal liquid A2 is mixed with 1000g of distilled water, decoct for the second time in a 97°C environment, the decoction time is controlled to be 1h, and after the second decoction, a second mixed medicinal liquid is obtained, and 500g of the second mixed medicinal liquid is taken as medicinal liquid B. 500 g of liquid A collected after the first decoction and 500 g of liquid B collected after the second decoction were combined together, and the cephalosporin lotion was prepared by sterilizing and filtering.

[0034] Embodiment 5:

[0035] Weigh 15g of Platycladus orientalis leaf, 10g of Drynaria fortunei, 6g of Artemisia argyi, 6g of Chrysanthemum, 6g of Mentha, 6g of Nepeta tenuifolia, 6g of Saposhnikovia divaricata, 6g of Ligusticum chuanxiong, 6g of Patchouli acutifolia, 6g of Nardostachys raphis, 6g of Vitex rotundifolia, 8g of Radix Polygoni Multiflori processed and 12g of Herba Scutellariae radix-sinensis, add 1000g of distilled water, soak for 30min in a 35°C environment, pour the medicinal materials together with the soaked distilled water into a decoction pot and perform the first decoction in a 95°C environment after the soaking, the decoction time is controlled to be 1h, and the first mixed medicinal liquid is obtained after the first decoction, 500g of the first mixed medicinal liquid is taken as medicinal liquid A1, and the remaining first mixed medicinal liquid is medicinal liquid A2. Then, the medicinal liquid A2 is mixed with 1000g of distilled water, and the second decoction is performed in a 95°C environment, the decoction time is controlled to be 1h, and the second mixed medicinal liquid is obtained after the second decoction, and 500g of the second mixed medicinal liquid is taken as medicinal liquid B. 500 g of liquid A collected after the first decoction and 500 g of liquid B collected after the second decoction were combined together, and the cephalosporin lotion was prepared by sterilizing and filtering.

[0036] Comparative Example 1:

[0037] The difference between this comparative example and Example 1 is that Platycladus orientalis leaves and Rhizoma Drynariae are not added to the medicinal materials, and the rest are consistent with Example 1.

[0038] Comparative Example 2:

[0039] The difference between this comparative example and Example 1 is that no processed Polygonum multiflorum component is added to the medicinal material, and the rest is consistent with Example 1.

[0040] Comparative Example 3:

[0041] The difference between this comparative example and Example 1 is that no Radix Persicae Sinensis component is added to the medicinal material, and the rest is consistent with Example 1.

[0042] Comparative Example 4:

[0043] The difference between this comparative example and Example 1 is that Platycladus orientalis leaf, Drynaria fortunei, processed Polygonum multiflorum and Herba speranskiae radix are not added to the medicinal materials, and the rest are consistent with Example 1.

[0044] Test Example 1: Test on the effect of inhibiting 5-α reductase activity

[0045] The test was divided into 11 groups, including a blank control group, a positive control group, an example group and a comparative example group. The reaction system was 120 μL of 60 μM testosterone, 60 μL of 5-α reductase extract, 60 μL of the test substance and 120 μM NADPH 120 μL. The test substance of the blank control group was purified water, the test substance of the positive control group was finasteride, the test substance of the example group was the side-ai wash prepared in Examples 1 to 5, and the test substance of the comparative example group was the side-ai wash prepared in Comparative Examples 1 to 4. Each reaction system was reacted in a 37°C temperature environment for 15 minutes, and then 20 μL was injected into the high-performance liquid phase. The testosterone peak area in the sample was substituted into the standard curve to calculate the corresponding testosterone concentration, and the 5-α reductase inhibition rate was calculated according to the testosterone concentration. The results are shown in Table 1 below.

[0046] Table 1.5-α reductase inhibition rate results

[0047]

[0048]

[0049] As shown in Table 1, the results show that the positive drug finasteride has a good inhibitory effect on 5-α reductase, and the inhibitory effect of the side moxa lotion prepared in Examples 1 to 5 of the present invention on 5-α reductase is significantly better than that of the side moxa lotion prepared in Comparative Examples 1 to 4, indicating that the side moxa lotion prepared by the present invention using specific components (Platyra orientalis leaves, Drynaria fortunei, Polygonum multiflorum processed, Herba scutellariae) and fixed proportions can enhance the inhibitory effect on 5-α reductase through synergistic effects, and the synergistic effects of multiple components can greatly avoid the catalytic conversion of testosterone into DHT by 5-α reductase, thereby avoiding the binding of highly active DHT to androgen receptors.

[0050] Test Example 2: Skin irritation test

[0051] 80 volunteers were selected, aged 18 to 24 years old, half male and half female, and none of them had skin diseases. According to the basic principles and methods of human skin patch test in the 2015 edition of the "Technical Specifications for Safety of Cosmetics" of the Ministry of Health of the People's Republic of China, the human skin patch test of Examples 1 to 5 and Comparative Examples 1 to 4 of the present invention was carried out, and the specific method was as follows: 0.025mL of the side Ai lotion was dripped on the filter paper attached to the patch tester as the test sample and placed in the patch tester. The patch tester with the test object was applied to the back of the subject with a low-allergenic tape, and it was lightly pressed with the palm of the hand to be evenly applied to the skin for 24 hours. The blank control group was an ethanol-water solution, and the volume fraction of ethanol in the ethanol-water solution was 50%. The number of people who had skin irritation reactions was recorded at 30 minutes (after the indentation disappears), 24 hours and 48 hours after the removal of the test object patch tester, and the results are shown in Table 2 below.

[0052] Table 2. Skin irritation test results

[0053]

[0054]

[0055] The results are shown in Table 2. Compared with the blank control group, the side mugwort lotion prepared in comparative examples 1 to 4 of the present invention will have some irritation to the skin, while the side mugwort lotion prepared in embodiments 1 to 5 has no irritation to the skin, which further illustrates the importance of formulating the side mugwort lotion prepared in the present invention according to the monarch, minister, assistant and guiding ingredients, and also illustrates that the side mugwort lotion prepared in the present invention has a high potential for clinical application.

[0056] Test Example 3: Anti-hair loss and hair growth effect evaluation test

[0057] 100 volunteers with androgenic alopecia were selected, aged 25 to 55 years old. The subjects were randomly divided into 10 groups, including a blank control group and an experimental group (Examples 1 to 5 and Comparative Examples 1 to 4), with 10 subjects in each group, and there were no significant differences in age and hair loss conditions. Test method: The experimental group applied the side-wormwood lotion prepared in Examples 1 to 5 and Comparative Examples 1 to 4 once a day, taking 2 mL of the side-wormwood lotion each time and applying it to the scalp and hair roots, and massaging for 15 to 30 minutes. One month was a course of treatment, and there were three courses in total. The blank control group applied an ethanol-water solution, and the volume fraction of ethanol in the ethanol-water solution was 50%. The test was a double-blind test. No other cosmetics, drugs, and health products that may affect the results were used during the test. According to the efficacy judgment standard, the percentage of people who produced anti-hair loss and hair growth effects before and after use was recorded, and the results are shown in Table 3.

[0058] The efficacy evaluation criteria are as follows: (1) No change: No improvement in oily scalp, dandruff and hair loss, no new hair growth after shampooing, and no obvious improvement in appearance; (2) Slight improvement: Reduced itching, reduced dandruff and hair loss, partial improvement in scalp environment, and no new hair growth. (3) Significant improvement: Reduced dandruff and itching, reduced hair loss, new hair growth, inhibition of excessive sebum secretion, improved appearance, and effective improvement in scalp environment.

[0059] Table 3. Anti-hair loss and hair growth test results

[0060]

[0061]

[0062] Test Example 4: Sustained efficacy test

[0063] The volunteers in Test Example 3 were tested for their daily average hair loss within one week before use, the daily average hair loss within one week after use for three months, and the daily average hair loss within one week after use for three months and then one month of discontinuation (unit: roots). The results are shown in Table 4.

[0064] Table 4. Results of drug efficacy persistence test

[0065]

[0066] As shown in Table 3 and Table 4, the effects of the side-ai lotion prepared in Examples 1 to 5 on preventing hair loss and promoting hair growth and the sustained efficacy are better than those prepared in Comparative Examples 1 to 4. This result shows that the side-ai lotion of the present invention is better than other forms of combination in improving hair loss symptoms. The side-ai lotion of the present invention can not only stimulate the transition of hair follicles from the resting phase to the growth phase, promote hair follicle cell proliferation and hair growth, improve various symptoms such as scalp itching, desquamation and greasy, and exert excellent anti-hair loss effects, but also can continuously exert efficacy, regulate the scalp microenvironment, promote hair follicle health, and promote hair regeneration.

[0067] The above-described embodiments provide a detailed description of the technical solutions and beneficial effects of the present invention. It should be understood that the above description is only a specific embodiment of the present invention and is not intended to limit the present invention. Without departing from the spirit and scope of the present invention, the present invention may have various changes and improvements, which fall within the scope of the present invention to be protected.

Claims

1. A side moxa lotion, characterized in that The side moxa lotion comprises the following Chinese medicines: Platycladus orientalis leaves, drynaria root, wormwood leaf, chrysanthemum, mint, schizonepeta, siler, ligusticum chuanxiong, patchouli, nard, vitex rotundifolia, processed polygonum multiflorum and scutellaria baicalensis.

2. A side moxa lotion as claimed in claim 1, characterized in that The mass ratio of Platycladus orientalis leaf: Drynaria fortunei: Artemisia argyi: Chrysanthemum: Menthus alba: Nepeta tenuifolia: Saposhnikovia divaricata: Ligusticum chuanxiong: Patchouli acuminata: Nardostachys chinensis: Vitex rotundus: processed Polygonum multiflorum: Herba speranskiae radix et Rhizoma is 10-20:7-15:3-6:3-6:3-6:3-6:3-6:3-6:3-6:3-6:3-6:3-6:8-10:10-15.

3. A side moxa lotion as claimed in claim 2, characterized in that: The mass ratio of the arborvitae leaf: drynaria root: wormwood leaf: chrysanthemum: mint: schizonepeta: siler: ligusticum chuanxiong: patchouli: nardostachys grandiflora: vitex rotundus: processed polygonum multiflorum: radix spatholobi is 15: 10：6：6：6：6：6：6：6：6：6：10：15。 4. A method for preparing a side moxa lotion as claimed in any one of claims 1 to 3, characterized in that: The preparation method comprises the following steps: preparing 10 to 20 parts by weight of Platycladus orientalis leaves, 7 to 15 parts by weight of Drynaria fortunei, 3 to 6 parts by weight of Artemisia argyi, 3 to 6 parts by weight of Chrysanthemum, 3 to 6 parts by weight of Menthus officinalis, 3 to 6 parts by weight of Nepeta tenuifolia, 3 to 6 parts by weight of Saposhnikovia divaricata, 3 to 6 parts by weight of Ligusticum chuanxiong, 3 to 6 parts by weight of Patchouli scabra, 3 to 6 parts by weight of Nardostachys grandiflora, 3 to 6 parts by weight of Vitex rotundifolia, 8 to 10 parts by weight of Polygonum multiflorum processed and 10 to 15 parts by weight of Herba schizonepetae after adding distilled water for soaking, performing a first decoction after the soaking to obtain a first mixed medicinal liquid, taking 300 to 700 parts by weight of the first mixed medicinal liquid as medicinal liquid A1, and the remaining first mixed medicinal liquid as medicinal liquid A2; The medicinal solution A2 is mixed with water and then boiled for a second time to obtain a second mixed medicinal solution, and 300 to 700 parts by weight of the second mixed medicinal solution is taken as medicinal solution B; The medicinal solution A1 and the medicinal solution B are mixed and then sterilized and filtered to obtain the side moxa wash.

5. The method for preparing a side moxa lotion according to claim 4, characterized in that: The conditions for distilled water soaking include a soaking temperature of 25 to 35° C. and a soaking time of 10 to 30 minutes.

6. The method for preparing a side moxa lotion according to claim 4, characterized in that: The conditions for the first decoction include a decoction temperature of 95-100° C. and a decoction time of 1-2 hours.

7. The method for preparing a side moxa lotion according to claim 4, characterized in that: The conditions for the second decoction include a decoction temperature of 95-100° C. and a decoction time of 1-2 hours.

8. Use of a side moxa lotion as claimed in any one of claims 1 to 3 or a side moxa lotion prepared by the preparation method of a side moxa lotion as claimed in any one of claims 4 to 7 in the treatment of hair loss, characterized in that: The dosage form of the side moxa lotion used is a liquid preparation.

9. The use of the side-wormwood lotion as claimed in claim 8 in treating and preventing hair loss, characterized in that: The side moxa lotion used is an external preparation.

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