Production method of medical cotton swabs through multi-stage disinfection and sterile packaging

Abstract

The invention discloses a method for producing medical cotton swabs through multi-stage disinfection and sterile packaging. According to the antibacterial cotton swab disclosed by the invention, the antibacterial agent ensures that the nano-silver particles are uniformly dispersed and stably combined on the cotton swab material through a precise preparation process, and the beneficial effects of the antibacterial agent are maximized: the elaborately designed formula can provide a continuous antibacterial effect, and the large specific surface area of the nano-silver particles ensures that the nano-silver particles are in full contact with microorganisms; the addition of triclosan and quaternary ammonium salt enhances the antibacterial spectrum and is effective to various pathogens, and the slow-release carrier can effectively control the release rate of the antibacterial agent in the preparation process, so that the antibacterial agent can continuously play a role in a relatively long time; the slow-release carrier enables the antibacterial agent to be slowly released on the surface of the cotton swab or in the cotton swab, so that the antibacterial effect can be kept for a longer time, the need of frequently replacing disinfection products is reduced, and the stability of the antibacterial agent is enhanced.

Description

Technical Field

[0001] The invention belongs to the technical field of medical cotton swabs, and specifically relates to a production method of multi-stage disinfected and aseptically packaged medical cotton swabs. Background Art

[0002] In the medical field, medical cotton swabs, as a common medical consumable, are widely used in wound care, disinfection, sampling and other operations. Since they are in direct contact with the patient's skin or mucous membrane, the sterility and antibacterial properties of medical cotton swabs are crucial. However, traditional medical cotton swab production methods often have some shortcomings, such as limited antibacterial effect, too fast release rate of antibacterial agents, low production efficiency, inconsistent product quality and other problems. Among the existing medical cotton swab production methods, some use antibacterial agents to improve the antibacterial ability of cotton swabs.

[0003] However, these methods often have the following technical problems: the selection and ratio of antimicrobial agents are not reasonable, resulting in poor antimicrobial effect or irritation to the skin. The addition method of antimicrobial agents may cause uneven distribution on the cotton swab, affecting the durability of the antimicrobial effect. Summary of the invention

[0004] The purpose of the present invention is to provide a production method of multi-stage disinfection and aseptic packaging medical cotton swabs in order to solve the above-mentioned problems.

[0005] The technical solution adopted by the present invention is as follows: a production method of multi-stage disinfection and aseptic packaging medical cotton swabs, characterized in that the method comprises the following steps:

[0006] S1: Raw material preparation, select high-quality cotton as the raw material for medical cotton swabs. Prepare a sufficient number of bamboo or plastic swabs as the support part of the cotton swabs;

[0007] S2: Put the cotton into the cutting machine and cut it according to the specified size to ensure that the cotton pieces are of uniform size. Check the cut cotton and remove the unqualified parts;

[0008] S3: Place the cut cotton into a pre-sterilized container. Use 75% alcohol or ultraviolet light to pre-sterilize the cotton for a certain period of time;

[0009] S4: Prepare the antimicrobial agent and spray or soak the cotton evenly. This ensures that the antimicrobial agent is evenly absorbed and has enough time to combine with the cotton material before the cotton is assembled into a cotton swab;

[0010] S5: Before assembling the cotton swab, evenly apply or soak the bamboo or plastic swab with the antimicrobial solution, and then fix the pre-sterilized cotton on the treated swab. In this way, the antimicrobial agent will not only be absorbed by the cotton, but also by the surface of the swab, thus providing antimicrobial protection on the overall structure of the cotton swab;

[0011] S6: Fix the sprayed cotton on the bamboo or plastic stick to ensure it is firmly fixed. Check the assembly quality of the cotton swab to ensure that it is not loose or falling off;

[0012] S7: Place the assembled cotton swab into the preliminary disinfection device. Use high-temperature steam or ethylene oxide gas to perform preliminary disinfection on the cotton swab;

[0013] S8: Cool the cotton swab after preliminary disinfection to room temperature. Avoid contamination during the cooling process;

[0014] S9: Prepare sterile packaging materials, such as aluminum foil bags, medical plastic bags, etc. Sterilize the packaging materials with ultraviolet light to ensure sterility. Divide the cooled cotton swabs into sterile packaging bags according to the specified quantity. Ensure that the cotton swabs are not contaminated during the dividual packaging process;

[0015] S10: Use aseptic sealing equipment to seal the packaging bag. Check the sealing quality to ensure a good seal;

[0016] S11: Place the sealed sterile packaged cotton swabs into the final sterilization equipment. Use high-temperature steam or ethylene oxide gas to perform final sterilization on the cotton swabs. After that, the entire multi-stage sterilization and sterile packaging medical cotton swab production process is completed.

[0017] In a preferred embodiment, in step S4, the antibacterial agent comprises:

[0018] 5-10 parts by weight of nano silver particles;

[0019] 15-20 parts by weight of triclosan;

[0020] 25-30 parts by weight of quaternary ammonium salt;

[0021] 200-230 parts by weight of polylactic acid-glycolic acid copolymer;

[0022] 500-550 parts by weight of polyethylene glycol;

[0023] 9500-9550 parts by weight of distilled water.

[0024] In a preferred embodiment, in step S4, the method for preparing the antibacterial agent comprises:

[0025] Add PLGA and PEG into distilled water, heat to a suitable temperature, and stir until completely dissolved.

[0026] With gentle stirring, add the nanosilver particles to ensure even dispersion.

[0027] Add triclosan and quaternary ammonium salt in sequence and continue stirring until completely dissolved.

[0028] The mixed solution was filtered to remove undissolved particles and impurities.

[0029] Store the prepared antimicrobial solution in a sterile container for future use.

[0030] In a preferred embodiment, in step S2, the blade of the cutting machine should be replaced every 1000 meters of cutting to ensure cutting accuracy. The cutting size is set to 8 mm × 8 mm cotton pieces. The cutting speed should be controlled at 50-60 cotton pieces per minute. The inspection area should maintain a relative humidity between 30% and 50% and a temperature between 18-24°C.

[0031] In a preferred embodiment, in step S3, when 75% alcohol is used for pre-disinfection, the immersion time should be exactly 7 minutes. The irradiation intensity of ultraviolet disinfection is set to 1200 μW / cm 2 , the irradiation time should be 35 minutes. The internal temperature of the pre-sterilized container should be controlled at 20-25℃.

[0032] In a preferred embodiment, in step S5, the pH value of the antibacterial agent is adjusted to 6.5-7.5. When spraying the antibacterial agent, the distance between the nozzle and the cotton surface should be maintained at 10-15 cm. The soaking time is set to 8 minutes, and the drying temperature does not exceed 40°C.

[0033] In a preferred embodiment, in step S7, the temperature of high temperature steam sterilization is set to 125°C, the pressure is 1.2 bar, the duration is 18 minutes, the concentration of ethylene oxide gas sterilization is 900 mg / L, the temperature is 55°C, the relative humidity is 45%, and the sterilization time is 1.5 hours.

[0034] In a preferred embodiment, in step S9, the time for aseptic packaging preparation and subpackaging ultraviolet irradiation disinfection is 1.5 hours, and the air flow rate in the clean room should be maintained at 0.4 cubic meters per second per square meter. During subpackaging, the number of cotton swabs per package is precisely 50, and the operator's action should be completed within one minute to reduce exposure time.

[0035] In a preferred embodiment, in step S10, the sealing temperature of the aseptic sealing device is set to 180°C and the sealing time is 2 seconds. The sealed packaging bag should be inspected within 30 minutes to ensure that the width of the sealing line is 2-3 mm.

[0036] In a preferred embodiment, in step S11, the parameters of the final sterilization high temperature steam sterilization are the same as those of the initial sterilization. The cooling time after ethylene oxide gas sterilization should be at least 1.5 hours, the ambient temperature should be controlled at 15-25°C, and the relative humidity should be maintained at 30%-50%. The sterilized cotton swabs should be stored under sterile conditions, and the temperature of the storage environment should be controlled at 2-8°C.

[0037] In summary, due to the adoption of the above technical solution, the beneficial effects of the present invention are:

[0038] 1. In the present invention, the antibacterial agent ensures uniform dispersion and stable bonding of nanosilver particles to the cotton swab material through a precise preparation process, and the beneficial effects of the antibacterial agent are maximized: this carefully designed formula can provide a continuous antibacterial effect, and the large specific surface area of ​​the nanosilver particles ensures sufficient contact with microorganisms, thereby quickly killing or inhibiting their growth, while the addition of triclosan and quaternary ammonium salts enhances the antibacterial spectrum and is effective against a variety of pathogens, including some difficult-to-deal drug-resistant strains; in addition, the slow-release carrier in the preparation process can effectively control the release rate of the antibacterial agent, ensuring that the antibacterial agent continues to play a role for a long time, and the slow-release carrier enables the antibacterial agent to be slowly released on the surface or inside of the cotton swab, so that the antibacterial effect can be maintained for a longer time, reducing the need to frequently replace disinfection products. Through the slow-release technology, the antibacterial agent can continue to play a role during the critical period of microbial growth, thereby more effectively inhibiting bacterial reproduction and improving the overall antibacterial efficiency. Since the slow-release carrier can control the release of the antibacterial agent, the total amount of the antibacterial agent required can be reduced while achieving the same antibacterial effect, reducing costs and potential side effects. Sustained-release carriers help protect antimicrobial agents from environmental factors such as light, temperature changes, etc., thereby enhancing the stability of antimicrobial agents.

[0039] 2. In the present invention, a multi-stage sterilization process, including pre-sterilization, high-temperature steam sterilization, ethylene oxide gas sterilization, etc., is used to ensure the high sterility of medical cotton swabs and reduce the risk of infection during use. Through precise cutting and packaging steps, the consistency of the size, weight and cotton content of each cotton swab is ensured, and the overall quality of the product is improved. The treatment with antimicrobial agents enhances the antibacterial properties of cotton swabs, and can effectively inhibit the growth of microorganisms even if they come into contact with them during use. Sterile packaging and appropriate storage conditions significantly extend the shelf life of medical cotton swabs and reduce waste caused by expired products. Through strict quality inspection and sealing inspection, the safety of the product during transportation and use is ensured, and product contamination caused by damaged packaging is avoided. The automated and standardized production process improves production efficiency, reduces manual errors, and reduces production costs. Strict control of environmental conditions during the production process ensures the stability and reliability of the product throughout the production process. DETAILED DESCRIPTION

[0040] In order to make the purpose, technical solution and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with the embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0041] Embodiment 1:

[0042] A method for producing multi-stage disinfection and aseptic packaging medical cotton swabs, the method comprising the following steps:

[0043] S1: Raw material preparation, select high-quality cotton as the raw material for medical cotton swabs. Prepare a sufficient number of bamboo or plastic swabs as the support part of the cotton swabs;

[0044] S2: Put the cotton into the cutting machine and cut it according to the specified size to ensure that the cotton pieces are of uniform size. Check the cut cotton and remove the unqualified parts;

[0045] S3: Place the cut cotton into a pre-sterilized container. Use 75% alcohol or ultraviolet light to pre-sterilize the cotton for a certain period of time;

[0046] S4: Prepare the antimicrobial agent and spray or soak the cotton evenly. This ensures that the antimicrobial agent is evenly absorbed and has enough time to combine with the cotton material before the cotton is assembled into a cotton swab;

[0047] S5: Before assembling the cotton swab, evenly apply or soak the bamboo or plastic swab with the antimicrobial solution, and then fix the pre-sterilized cotton on the treated swab. In this way, the antimicrobial agent will not only be absorbed by the cotton, but also by the surface of the swab, thus providing antimicrobial protection on the overall structure of the cotton swab;

[0048] In step S4, the antimicrobial agent includes:

[0049] 5-10 parts by weight of nano silver particles; highly effective antibacterial agent, providing long-term antibacterial effect 15-20 parts by weight of triclosan; antibacterial agent, enhancing broad-spectrum antibacterial ability

[0050] Quaternary ammonium salt (such as benzalkonium bromide) 25-30 parts by weight; antibacterial agent, providing rapid bactericidal effect

[0051] 200-230 parts by weight of polylactic acid-glycolic acid copolymer (PLGA) sustained-release carrier, used to control the release of antibacterial agents

[0052] Polyethylene glycol (PEG) 500-550 parts by weight; solvent and stabilizer, to improve the stability of the solution and the compatibility of the materials

[0053] 9500-9550 parts by weight of distilled water; diluent, used to prepare the solution.

[0054] S6: Fix the sprayed cotton on the bamboo or plastic stick to ensure it is firmly fixed. Check the assembly quality of the cotton swab to ensure that it is not loose or falling off;

[0055] S7: Place the assembled cotton swab into the preliminary disinfection device. Use high-temperature steam or ethylene oxide gas to perform preliminary disinfection on the cotton swab;

[0056] S8: Cool the cotton swab after preliminary disinfection to room temperature. Avoid contamination during the cooling process;

[0057] S9: Prepare sterile packaging materials, such as aluminum foil bags, medical plastic bags, etc. Sterilize the packaging materials with ultraviolet light to ensure sterility. Divide the cooled cotton swabs into sterile packaging bags according to the specified quantity. Ensure that the cotton swabs are not contaminated during the dividual packaging process;

[0058] S10: Use aseptic sealing equipment to seal the packaging bag. Check the sealing quality to ensure a good seal;

[0059] S11: Place the sealed sterile packaged cotton swabs into the final sterilization equipment. Use high-temperature steam or ethylene oxide gas to perform final sterilization on the cotton swabs. After that, the entire multi-stage sterilization and sterile packaging medical cotton swab production process is completed.

[0060] Nanosilver particles: Using nanosilver can improve antibacterial efficiency because they can penetrate deeper into the bacterial cell wall and destroy the cell structure.

[0061] PLGA: As a sustained-release carrier, PLGA can form a thin film on the surface of the material, gradually releasing the antibacterial agent and prolonging the antibacterial effect.

[0062] PEG: Improves the stability of the solution and the compatibility of the material, while helping to evenly distribute the antimicrobial agent on the surface of the material.

[0063] In step S4, the method for preparing the antibacterial agent comprises:

[0064] Add PLGA and PEG into distilled water, heat to a suitable temperature, and stir until completely dissolved.

[0065] With gentle stirring, add the nanosilver particles to ensure even dispersion.

[0066] Add triclosan and quaternary ammonium salt in sequence and continue stirring until completely dissolved.

[0067] The mixed solution was filtered to remove undissolved particles and impurities.

[0068] Store the prepared antimicrobial solution in a sterile container for future use.

[0069] In step S2, the blade of the cutting machine should be replaced every 1000 meters of cutting to ensure cutting accuracy. The cutting size is set to 8 mm × 8 mm cotton pieces. The cutting speed should be controlled at 50-60 cotton pieces per minute. The inspection area should maintain a relative humidity between 30% and 50% and a temperature between 18-24°C to prevent the cotton from absorbing moisture and becoming damp.

[0070] In step S3, when 75% alcohol is used for pre-disinfection, the immersion time should be exactly 7 minutes. The irradiation intensity of ultraviolet disinfection is set to 1200 μW / cm 2 , the irradiation time should be 35 minutes. The internal temperature of the pre-sterilized container should be controlled at 20-25℃.

[0071] In step S5, the pH value of the antibacterial agent is adjusted to 6.5-7.5. When spraying the antibacterial agent, the distance between the nozzle and the cotton surface should be maintained at 10-15 cm. The soaking time is set to 8 minutes, and the drying temperature does not exceed 40°C.

[0072] In step S7, the temperature of high temperature steam sterilization is set to 125°C, the pressure is 1.2 bar, the duration is 18 minutes, the concentration of ethylene oxide gas sterilization is 900 mg / L, the temperature is 55°C, the relative humidity is 45%, and the sterilization time is 1.5 hours.

[0073] In step S9, the time for aseptic packaging preparation and subpackaging ultraviolet irradiation disinfection is 1.5 hours, and the air flow rate in the clean room should be maintained at 0.4 cubic meters per second per square meter. When subpackaging, the number of cotton swabs per package is precisely 50, and the operator's actions should be completed within one minute to reduce exposure time.

[0074] In step S10, the sealing temperature of the aseptic sealing device is set to 180°C and the sealing time is 2 seconds. The sealed packaging bag should be inspected within 30 minutes to ensure that the width of the sealing line is 2-3 mm.

[0075] In step S11, the parameters of the final high-temperature steam sterilization are the same as those of the initial sterilization. The cooling time after ethylene oxide gas sterilization should be at least 1.5 hours, the ambient temperature should be controlled at 15-25°C, and the relative humidity should be maintained at 30%-50%. The sterilized cotton swabs should be stored under sterile conditions, and the temperature of the storage environment should be controlled at 2-8°C.

[0076] Embodiment 2:

[0077] A method for producing multi-stage disinfection and aseptic packaging medical cotton swabs, the method comprising the following steps:

[0078] S1: Raw material preparation, select high-quality cotton as the raw material for medical cotton swabs. Prepare a sufficient number of bamboo or plastic swabs as the support part of the cotton swabs;

[0079] S2: Put the cotton into the cutting machine and cut it according to the specified size to ensure that the cotton pieces are of uniform size. Check the cut cotton and remove the unqualified parts;

[0080] S3: Place the cut cotton into a pre-sterilized container. Use 75% alcohol or ultraviolet light to pre-sterilize the cotton for a certain period of time;

[0081] S4: Prepare the antimicrobial agent and spray or soak the cotton evenly. This ensures that the antimicrobial agent is evenly absorbed and has enough time to combine with the cotton material before the cotton is assembled into a cotton swab;

[0082] S5: Before assembling the cotton swab, evenly apply or soak the bamboo or plastic swab with the antimicrobial solution, and then fix the pre-sterilized cotton on the treated swab. In this way, the antimicrobial agent will not only be absorbed by the cotton, but also by the surface of the swab, thus providing antimicrobial protection on the overall structure of the cotton swab;

[0083] In step S4, the antimicrobial agent includes:

[0084] 5-10 parts by weight of nano silver particles; highly effective antibacterial agent, providing long-term antibacterial effect 15-20 parts by weight of triclosan; antibacterial agent, enhancing broad-spectrum antibacterial ability

[0085] Quaternary ammonium salt (such as benzalkonium bromide) 25-30 parts by weight; antibacterial agent, providing rapid bactericidal effect

[0086] 200-230 parts by weight of polylactic acid-glycolic acid copolymer (PLGA) sustained-release carrier, used to control the release of antibacterial agents

[0087] Polyethylene glycol (PEG) 500-550 parts by weight; solvent and stabilizer, to improve the stability of the solution and the compatibility of the materials

[0088] 9500-9550 parts by weight of distilled water; diluent, used to prepare the solution.

[0089] S6: Fix the sprayed cotton on the bamboo or plastic stick to ensure it is firmly fixed. Check the assembly quality of the cotton swab to ensure that it is not loose or falling off;

[0090] S7: Place the assembled cotton swab into the preliminary disinfection device. Use high-temperature steam or ethylene oxide gas to perform preliminary disinfection on the cotton swab;

[0091] S8: Cool the cotton swab after preliminary disinfection to room temperature. Avoid contamination during the cooling process;

[0092] S9: Prepare sterile packaging materials, such as aluminum foil bags, medical plastic bags, etc. Sterilize the packaging materials with ultraviolet light to ensure sterility. Divide the cooled cotton swabs into sterile packaging bags according to the specified quantity. Ensure that the cotton swabs are not contaminated during the dividual packaging process;

[0093] S10: Use aseptic sealing equipment to seal the packaging bag. Check the sealing quality to ensure a good seal;

[0094] S11: Place the sealed sterile packaged cotton swabs into the final sterilization equipment. Use high-temperature steam or ethylene oxide gas to perform final sterilization on the cotton swabs. After that, the entire multi-stage sterilization and sterile packaging medical cotton swab production process is completed.

[0095] Nanosilver particles: Using nanosilver can improve antibacterial efficiency because they can penetrate deeper into the bacterial cell wall and destroy the cell structure.

[0096] PLGA: As a sustained-release carrier, PLGA can form a thin film on the surface of the material, gradually releasing the antibacterial agent and prolonging the antibacterial effect.

[0097] PEG: Improves the stability of the solution and the compatibility of the material, while helping to evenly distribute the antimicrobial agent on the surface of the material.

[0098] In step S4, the method for preparing the antibacterial agent comprises:

[0099] Add PLGA and PEG into distilled water, heat to a suitable temperature, and stir until completely dissolved.

[0100] With gentle stirring, add the nanosilver particles to ensure even dispersion.

[0101] Add triclosan and quaternary ammonium salt in sequence and continue stirring until completely dissolved.

[0102] The mixed solution was filtered to remove undissolved particles and impurities.

[0103] Store the prepared antimicrobial solution in a sterile container for future use.

[0104] In step S2, the blade of the cutting machine should be replaced every 1000 meters of cutting to ensure cutting accuracy. The cutting size is set to 8 mm × 8 mm cotton pieces. The cutting speed should be controlled at 50-60 cotton pieces per minute. The inspection area should maintain a relative humidity between 30% and 50% and a temperature between 18-24°C to prevent the cotton from absorbing moisture and becoming damp.

[0105] In step S3, when 75% alcohol is used for pre-disinfection, the immersion time should be exactly 7 minutes. The irradiation intensity of ultraviolet disinfection is set to 1200 μW / cm 2, the irradiation time should be 35 minutes. The internal temperature of the pre-sterilized container should be controlled at 20-25℃.

[0106] In step S5, the pH value of the antibacterial agent is adjusted to 6.5-7.5. When spraying the antibacterial agent, the distance between the nozzle and the cotton surface should be maintained at 10-15 cm. The soaking time is set to 8 minutes, and the drying temperature does not exceed 40°C.

[0107] In step S7, the temperature of high temperature steam sterilization is set to 125°C, the pressure is 1.2 bar, the duration is 18 minutes, the concentration of ethylene oxide gas sterilization is 900 mg / L, the temperature is 55°C, the relative humidity is 45%, and the sterilization time is 1.5 hours.

[0108] In step S9, the time for aseptic packaging preparation and subpackaging ultraviolet irradiation disinfection is 1.5 hours, and the air flow rate in the clean room should be maintained at 0.4 cubic meters per second per square meter. When subpackaging, the number of cotton swabs per package is precisely 50, and the operator's actions should be completed within one minute to reduce exposure time.

[0109] In step S10, the sealing temperature of the aseptic sealing device is set to 180°C and the sealing time is 2 seconds. The sealed packaging bag should be inspected within 30 minutes to ensure that the width of the sealing line is 2-3 mm.

[0110] In step S11, the parameters of the final high-temperature steam sterilization are the same as those of the initial sterilization. The cooling time after ethylene oxide gas sterilization should be at least 1.5 hours, the ambient temperature should be controlled at 15-25°C, and the relative humidity should be maintained at 30%-50%. The sterilized cotton swabs should be stored under sterile conditions, and the temperature of the storage environment should be controlled at 2-8°C.

[0111] Embodiment three:

[0112] A method for producing multi-stage disinfection and aseptic packaging medical cotton swabs, the method comprising the following steps:

[0113] S1: Raw material preparation, select high-quality cotton as the raw material for medical cotton swabs. Prepare a sufficient number of bamboo or plastic swabs as the support part of the cotton swabs;

[0114] S2: Put the cotton into the cutting machine and cut it according to the specified size to ensure that the cotton pieces are of uniform size. Check the cut cotton and remove the unqualified parts;

[0115] S3: Place the cut cotton into a pre-sterilized container. Use 75% alcohol or ultraviolet light to pre-sterilize the cotton for a certain period of time;

[0116] S4: Prepare the antimicrobial agent and spray or soak the cotton evenly. This ensures that the antimicrobial agent is evenly absorbed and has enough time to combine with the cotton material before the cotton is assembled into a cotton swab;

[0117] S5: Before assembling the cotton swab, evenly apply or soak the bamboo or plastic swab with the antimicrobial solution, and then fix the pre-sterilized cotton on the treated swab. In this way, the antimicrobial agent will not only be absorbed by the cotton, but also by the surface of the swab, thus providing antimicrobial protection on the overall structure of the cotton swab;

[0118] In step S4, the antimicrobial agent includes:

[0119] 5-10 parts by weight of nano silver particles; highly effective antibacterial agent, providing long-term antibacterial effect 15-20 parts by weight of triclosan; antibacterial agent, enhancing broad-spectrum antibacterial ability

[0120] Quaternary ammonium salt (such as benzalkonium bromide) 25-30 parts by weight; antibacterial agent, providing rapid bactericidal effect

[0121] 200-230 parts by weight of polylactic acid-glycolic acid copolymer (PLGA) sustained-release carrier, used to control the release of antibacterial agents

[0122] Polyethylene glycol (PEG) 500-550 parts by weight; solvent and stabilizer, to improve the stability of the solution and the compatibility of the materials

[0123] 9500-9550 parts by weight of distilled water; diluent, used to prepare the solution.

[0124] S6: Fix the sprayed cotton on the bamboo or plastic stick to ensure it is firmly fixed. Check the assembly quality of the cotton swab to ensure that it is not loose or falling off;

[0125] S7: Place the assembled cotton swab into the preliminary disinfection device. Use high-temperature steam or ethylene oxide gas to perform preliminary disinfection on the cotton swab;

[0126] S8: Cool the cotton swab after preliminary disinfection to room temperature. Avoid contamination during the cooling process;

[0127] S9: Prepare sterile packaging materials, such as aluminum foil bags, medical plastic bags, etc. Sterilize the packaging materials with ultraviolet light to ensure sterility. Divide the cooled cotton swabs into sterile packaging bags according to the specified quantity. Ensure that the cotton swabs are not contaminated during the dividual packaging process;

[0128] S10: Use aseptic sealing equipment to seal the packaging bag. Check the sealing quality to ensure a good seal;

[0129] S11: Place the sealed sterile packaged cotton swabs into the final sterilization equipment. Use high-temperature steam or ethylene oxide gas to perform final sterilization on the cotton swabs. After that, the entire multi-stage sterilization and sterile packaging medical cotton swab production process is completed.

[0130] Nanosilver particles: Using nanosilver can improve antibacterial efficiency because they can penetrate deeper into the bacterial cell wall and destroy the cell structure.

[0131] PLGA: As a sustained-release carrier, PLGA can form a thin film on the surface of the material, gradually releasing the antibacterial agent and prolonging the antibacterial effect.

[0132] PEG: Improves the stability of the solution and the compatibility of the material, while helping to evenly distribute the antimicrobial agent on the surface of the material.

[0133] In step S4, the method for preparing the antibacterial agent comprises:

[0134] Add PLGA and PEG into distilled water, heat to a suitable temperature, and stir until completely dissolved.

[0135] With gentle stirring, add the nanosilver particles to ensure even dispersion.

[0136] Add triclosan and quaternary ammonium salt in sequence and continue stirring until completely dissolved.

[0137] The mixed solution was filtered to remove undissolved particles and impurities.

[0138] Store the prepared antimicrobial solution in a sterile container for future use.

[0139] In step S2, the blade of the cutting machine should be replaced every 1000 meters of cutting to ensure cutting accuracy. The cutting size is set to 8 mm × 8 mm cotton pieces. The cutting speed should be controlled at 50-60 cotton pieces per minute. The inspection area should maintain a relative humidity between 30% and 50% and a temperature between 18-24°C to prevent the cotton from absorbing moisture and becoming damp.

[0140] In step S3, when 75% alcohol is used for pre-disinfection, the immersion time should be exactly 7 minutes. The irradiation intensity of ultraviolet disinfection is set to 1200 μW / cm 2 , the irradiation time should be 35 minutes. The internal temperature of the pre-sterilized container should be controlled at 20-25℃.

[0141] In step S5, the pH value of the antibacterial agent is adjusted to 6.5-7.5. When spraying the antibacterial agent, the distance between the nozzle and the cotton surface should be maintained at 10-15 cm. The soaking time is set to 8 minutes, and the drying temperature does not exceed 40°C.

[0142] In step S7, the temperature of high temperature steam sterilization is set to 125°C, the pressure is 1.2 bar, the duration is 18 minutes, the concentration of ethylene oxide gas sterilization is 900 mg / L, the temperature is 55°C, the relative humidity is 45%, and the sterilization time is 1.5 hours.

[0143] In step S9, the time for aseptic packaging preparation and subpackaging ultraviolet irradiation disinfection is 1.5 hours, and the air flow rate in the clean room should be maintained at 0.4 cubic meters per second per square meter. When subpackaging, the number of cotton swabs per package is precisely 50, and the operator's actions should be completed within one minute to reduce exposure time.

[0144] In step S10, the sealing temperature of the aseptic sealing device is set to 180°C and the sealing time is 2 seconds. The sealed packaging bag should be inspected within 30 minutes to ensure that the width of the sealing line is 2-3 mm.

[0145] In step S11, the parameters of high temperature steam sterilization are the same as those of the initial sterilization. The cooling time after ethylene oxide gas sterilization should be at least 1.5 hours, the ambient temperature should be controlled at 15-25°C, and the relative humidity should be maintained at 30%-50%. The sterilized cotton swabs should be stored under sterile conditions, and the temperature of the storage environment should be controlled at 2-8°C.

[0146] From the above, it can be known that in the present invention, the antibacterial agent ensures the uniform dispersion and stable bonding of the nanosilver particles to the cotton swab material through a precise preparation process, and the beneficial effects of the antibacterial agent are maximized: this carefully designed formula can provide a continuous antibacterial effect, the large specific surface area of ​​the nanosilver particles ensures sufficient contact with the microorganisms, thereby quickly killing or inhibiting their growth, and the addition of triclosan and quaternary ammonium salts enhances the antibacterial spectrum, which is effective against a variety of pathogens, including some difficult-to-deal drug-resistant strains; in addition, the slow-release carrier in the preparation process can effectively control the release rate of the antibacterial agent, ensuring that the antibacterial agent continues to play a role for a long time, and the slow-release carrier enables the antibacterial agent to be slowly released on the surface or inside of the cotton swab, so that the antibacterial effect can be maintained for a longer time, reducing the need for frequent replacement of disinfection products. Through the slow-release technology, the antibacterial agent can continue to play a role during the critical period of microbial growth, thereby more effectively inhibiting bacterial reproduction and improving the overall antibacterial efficiency. Since the slow-release carrier can control the release of the antibacterial agent, the total amount of the antibacterial agent required can be reduced under the condition of achieving the same antibacterial effect, reducing costs and potential side effects. Sustained-release carriers help protect antimicrobial agents from environmental factors such as light, temperature changes, etc., thereby enhancing the stability of antimicrobial agents.

[0147] In the present invention, a multi-stage sterilization process, including pre-sterilization, high-temperature steam sterilization, ethylene oxide gas sterilization, etc., is used to ensure the high sterility of medical cotton swabs, and reduce the risk of infection during use. Through precise cutting and packaging steps, the consistency of the size, weight and cotton content of each cotton swab is ensured, and the overall quality of the product is improved. The treatment of antimicrobial agents enhances the antibacterial properties of cotton swabs, and can effectively inhibit the growth of microorganisms even if they are exposed to microorganisms during use. Sterile packaging and appropriate storage conditions significantly extend the shelf life of medical cotton swabs and reduce waste caused by expired products. Through strict quality inspection and sealing inspection, the safety of the product during transportation and use is ensured, and product contamination caused by damaged packaging is avoided. The automated and standardized production process improves production efficiency, reduces manual errors, and reduces production costs. Strict control of environmental conditions during the production process ensures the stability and reliability of the product throughout the production process.

[0148] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the term "comprises" or any other variant thereof is intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device. In the absence of further restrictions, the elements defined by the sentence "comprises a ..." do not exclude the existence of other identical elements in the process, method, article or device including the elements.

[0149] The above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit the same. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that the technical solutions described in the aforementioned embodiments may still be modified, or some of the technical features may be replaced by equivalents. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A method for producing multi-stage disinfection and aseptic packaging medical cotton swabs, characterized in that: The method comprises the following steps: S1: Raw material preparation, select high-quality cotton as the raw material of medical cotton swabs; prepare a sufficient number of bamboo sticks or plastic sticks as the supporting part of the cotton swabs; S2: Put the cotton into the cutting machine and cut it according to the specified size to ensure that the cotton pieces are of uniform size; check the cut cotton and remove the unqualified parts; S3: Place the cut cotton into a pre-sterilized container; use 75% alcohol or ultraviolet light to pre-sterilize the cotton for a certain period of time; S4: Prepare the antimicrobial agent and spray or soak the antimicrobial agent evenly on the cotton; before the cotton is assembled into a cotton swab, ensure that the antimicrobial agent is evenly absorbed and has enough time to combine with the cotton material; S5: Before assembling the cotton swab, evenly apply or soak the bamboo or plastic swab with the antimicrobial solution, and then fix the pre-sterilized cotton on the treated swab; S6: Fix the sprayed cotton on the bamboo or plastic stick to ensure it is firmly fixed; check the assembly quality of the cotton swab to ensure that it is not loose or falling off; S7: placing the assembled cotton swab into a preliminary disinfection device; using high-temperature steam or ethylene oxide gas to perform preliminary disinfection on the cotton swab; S8: Cool the cotton swab after preliminary disinfection to room temperature; avoid contamination during the cooling process; S9: Prepare sterile packaging materials and sterilize them with ultraviolet light to ensure sterility; pack the cooled cotton swabs and put them into sterile packaging bags according to the specified quantity; ensure that the cotton swabs are not contaminated during the packing process; S10: Use aseptic sealing equipment to seal the packaging bag; check the sealing quality to ensure a good seal; S11: Place the sealed sterile packaged cotton swabs into the final sterilization equipment; use high-temperature steam or ethylene oxide gas to perform final sterilization on the cotton swabs; then the entire multi-stage sterilization and sterile packaged medical cotton swab production process can be completed.

2. The method for producing a multi-stage sterilized and aseptically packaged medical cotton swab according to claim 1, characterized in that: In step S4, the antibacterial agent includes: 5-10 parts by weight of nano silver particles; 15-20 parts by weight of triclosan; 25-30 parts by weight of quaternary ammonium salt; 200-230 parts by weight of polylactic acid-glycolic acid copolymer; 500-550 parts by weight of polyethylene glycol; 9500-9550 parts by weight of distilled water.

3. The method for producing a multi-stage sterilized and aseptically packaged medical cotton swab according to claim 1, characterized in that: In step S4, the method for preparing the antibacterial agent comprises: Add PLGA and PEG into distilled water, heat to a suitable temperature, and stir until completely dissolved; Under gentle stirring, add the nanosilver particles to ensure even dispersion; Add triclosan and quaternary ammonium salt in sequence and continue stirring until completely dissolved; Filter the mixed solution to remove undissolved particles and impurities; Store the prepared antimicrobial solution in a sterile container for future use.

4. The method for producing a multi-stage sterilized and aseptically packaged medical cotton swab according to claim 1, characterized in that: In step S2, the blade of the cutting machine should be replaced every 1000 meters of cutting to ensure cutting accuracy; The cutting size is set to 8 mm × 8 mm cotton blocks; the cutting speed should be controlled at 50-60 cotton blocks per minute; the inspection area should maintain a relative humidity between 30% and 50% and a temperature between 18-24°C.

5. The method for producing a multi-stage sterilized and aseptically packaged medical cotton swab according to claim 1, characterized in that: In step S3, when 75% alcohol is used for pre-disinfection, the immersion time should be exactly 7 minutes; the irradiation intensity of ultraviolet disinfection is set to 1200 μW / cm 2 , the irradiation time should be 35 minutes; the internal temperature of the pre-sterilized container should be controlled at 20-25℃.

6. The method for producing a multi-stage sterilized and aseptically packaged medical cotton swab according to claim 1, characterized in that: In step S5, the pH value of the antibacterial agent is adjusted to 6.5-7.5; when spraying the antibacterial agent, the distance between the nozzle and the cotton surface should be maintained at 10-15 cm; the soaking time is set to 8 minutes, and the drying temperature does not exceed 40°C.

7. The method for producing a multi-stage sterilized and aseptically packaged medical cotton swab according to claim 1, characterized in that: In step S7, the temperature of high temperature steam sterilization is set to 125° C., the pressure is 1.2 bar, and the duration is 18 minutes; the concentration of ethylene oxide gas sterilization is 900 mg / L, the temperature is 55° C., the relative humidity is 45%, and the sterilization time is 1.5 hours.

8. The method for producing a multi-stage sterilized and aseptically packaged medical cotton swab according to claim 1, characterized in that: In step S9, the ultraviolet irradiation disinfection time is 1.5 hours, and the air flow rate of the clean room should be maintained at 0.4 cubic meters per second per square meter; when packaging, the number of cotton swabs in each package is precisely 50, and the operator's action should be completed within one minute to reduce the exposure time.

9. The method for producing a multi-stage sterilized and aseptically packaged medical cotton swab according to claim 1, characterized in that: In step S10, the sealing temperature of the aseptic sealing equipment is set to 180° C. and the sealing time is 2 seconds; the sealed packaging bag should be inspected within 30 minutes to ensure that the width of the sealing line is 2-3 mm.

10. The method for producing a multi-stage sterilized and aseptically packaged medical cotton swab according to claim 1, characterized in that: In step S11, the parameters of the final high-temperature steam sterilization are the same as those of the preliminary sterilization; the cooling time after ethylene oxide gas sterilization should be at least 1.5 hours, the ambient temperature should be controlled at 15-25°C, and the relative humidity should be maintained at 30%-50%; the sterilized cotton swabs should be stored under sterile conditions, and the temperature of the storage environment should be controlled at 2-8°C.