Compound dried ginger formula granules and preparation method thereof
Through the combination of dried ginger formula granules, combined with the combination of dried ginger extract and other Chinese medicinal materials, and using advanced extraction and granulation technology, the problems of unstable efficacy and increased immunity of traditional dried ginger preparations have been solved, achieving significant efficacy of the medicine Improvement and stability.
Patent Information
- Application Number
- CN202411192231.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-08-28
- Publication Date
- 2024-12-31
AI Technical Summary
The efficacy of traditional dried ginger preparations is unstable and it is difficult to significantly improve the immunity of people with weak constitutions.
Compound dried ginger formula granules, the raw materials include dried ginger extract, Atractylodes macrocephala, licorice, Dendrobium extract, Angelica sinensis, antler, aconite extract, Cordyceps, fillers, disintegrants and wetting agents, and are extracted through supercritical CO2 fluid , ethanol extraction and ultrasonic extraction can extract effective ingredients, and make granules through dry granulation technology to ensure the stability of the drug effect and the improvement of immunity.
It improves the efficacy stability of the dried ginger formula granules and the immunity of people with weak constitutions, achieves a significant improvement in the efficacy, and the product remains effective during the shelf life.
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Figure CN119215135A_ABST
Abstract
Description
Technical Field
[0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a compound dried ginger formula granule and a preparation method thereof. Background Art
[0002] In traditional Chinese medicine, dried ginger is a common medicinal material and is widely used to treat various diseases, especially for people with weak constitution and low immunity. However, traditional dried ginger preparations have some problems, such as unstable efficacy and difficulty in significantly improving the immunity of some people. In order to solve these problems, a compound dried ginger formula granule and its preparation method were developed. Summary of the invention
[0003] 1. Technical issues to be resolved In view of the deficiencies in the prior art, the present invention provides a compound dried ginger formula granule and a preparation method thereof, which has the advantages of high stability in drug efficacy and improving the immunity of people with weak and cold constitutions, and solves the problem that traditional drugs have unstable efficacy and cannot improve the immunity of people with weak and cold constitutions.
[0004] (II) Technical solution To achieve the above object, the present invention provides the following technical scheme: a compound dried ginger formula granule and a preparation method thereof, wherein the raw material components include: dried ginger extract, atractylodes macrocephala, licorice, dendrobium extract, angelica, pilose antler, ginseng, aconite extract, cordyceps, filler, disintegrant and wetting agent; The raw material components are as follows: 30-33 parts of dried ginger extract; 3-6 parts of white atractylodes; 5-9 parts of liquorice; 4-7 parts of dendrobium extract; 1-3 parts of angelica; 0.75-1.00 parts of pilose antler; 1-3 parts of ginseng; 7-11 parts of aconite extract; 0.2-0.7 parts of cordyceps; 12-14 parts of filler; 0.2-0.6 parts of disintegrant; 0.4-0.7 parts of wetting agent.
[0005] Preferably, the preparation process of the dried ginger extract is: S1.1. Raw material preparation: Wash, slice, dry and dry ginger. After turning into dried ginger, use an ultrafine grinder to grind the dried ginger into dried ginger powder with a particle size of 1mm-1.2mm; S1.2. Equipment selection and parameter setting: Use SFE-2 supercritical CO2 fluid extractor, set the extraction temperature to 35°C, set the extraction pressure to 20 MPa, and set the extraction time to 1h; S1.3, Extraction process: put the dried ginger powder into the extraction tank, add 150% supercritical CO2 of the dried ginger powder as solvent, and start the SFE-2 supercritical CO2 fluid extractor for extraction.
[0006] Preferably, the preparation process of the Dendrobium extract is: S2.1, pretreatment: washing the raw materials of Dendrobium; S2.2, crushing: crushing the washed dendrobium raw material into dendrobium coarse powder using a blade crusher; S2.3, extraction: use 75% ethanol for extraction, add the crude powder of dendrobium to 150% ethanol by weight of the crude powder of dendrobium to form a mixed solution, use a centrifuge to centrifuge the mixed solution at a speed of 1000 rpm for 30 minutes, let it stand for 3 hours, and then take the supernatant.
[0007] Preferably, the preparation process of the aconite extract is: S3.1. Selection and cleaning: Select pest-free and pollution-free raw materials of aconite extract and clean them; S3.2, cutting and crushing: using a cutting machine to cut the washed aconite extract into pieces of 0.5 cm-0.8 cm; S3.3. Extraction: Mix the cut aconite extract with water in a ratio of 1:3, and extract by ultrasonic extraction method. Set the extraction time to 1 hour and the extraction temperature to 45°C.
[0008] S3.4, Filtration: After extraction, the mixture was centrifuged at 200 rpm for 30 min, and after standing for 1.5 h, the supernatant and the residue were separated; S3.5. Concentration: The separated supernatant is evaporated at a constant temperature of 100°C to concentrate it to 1 / 10 of its original volume.
[0009] Preferably, a method for preparing compound dried ginger formula granules is prepared according to the weight parts of the raw material components of the above-mentioned compound dried ginger formula granules, comprising the following steps: Step 1: Pretreatment: Clean and crush all medicinal materials; Step 2, extraction and grinding: extracting and grinding the raw materials; Step 3, weighing: weighing dried ginger extract, Atractylodes macrocephala, licorice, dendrobium extract, angelica, pilose antler, ginseng, aconite extract, cordyceps, filler, disintegrant and wetting agent according to the formula ratio; Step 4: Mix the raw material extracts in order, and then add the raw material powder; Step 5: Granulation: The mixture is made into granules by dry granulation technology; Step 6: Drying: Drying the prepared particles; Step 7: Packaging: Finally, the dried particles are sealed and packaged; Step 8. Content detection: Determine the content of the final product; Step 9. Activity detection and stability test: Conduct activity detection and stability test.
[0010] Preferably, in the step 2, the extraction and grinding are as follows: the raw materials of ginger, dendrobium and aconite are subjected to supercritical CO2 fluid extraction, ethanol extraction and water extraction respectively to obtain dried ginger extract, dendrobium extract and aconite extract; and white atractylodes, licorice, angelica, pilose antler, ginseng and cordyceps are ground into powders of 60 microns to 100 microns using ultrafine grinders respectively.
[0011] Preferably, the mixing process of the raw material extracts in step 4 is: first add the dried ginger extract, heat at 60°C for 2 minutes, then add the aconite extract, heat at 55°C for 3 minutes, and finally reduce the temperature to 40°C, add the dendrobium extract and heat for 8 minutes.
[0012] Preferably, in the step 4, the raw material grinding powder mixing process is as follows: first add angelica and ginseng, heat at 50°C for 1 min, then add atractylodes and pilose antler, heat at 35°C for 30s, and finally reduce the temperature to 40°C, add licorice and cordyceps and heat for 1 min.
[0013] Preferably, the dry granulation process in step 5 is: S4.1, mixing: uniformly mixing the mixed medicinal material particles in step 4 with the filler, disintegrant and wetting agent; S4.2, dry granulation: using a dry granulator to mechanically squeeze the powder mixture into a plate-like material; S4.3. Granulation: The pressed plate-like material is crushed and sieved to obtain particles within the particle size range required by the manufacturer. The prepared particles are vacuum-packed in sterile medical packaging bags.
[0014] Preferably, the drying conditions in step six are: in a sterile oven, the oven temperature is set to 80° C., and the drying time is set to 40 min.
[0015] Compared with the prior art, the present invention provides a compound dried ginger formula granule and a preparation method thereof, which has the following beneficial effects: 1. The finished product of the dried ginger formula granules of the present invention has the basic properties of warming the middle and dispersing cold. After adding ginseng and deer antler, it contains a variety of vitamins and nutrients. The combined addition of dendrobium extract, aconite extract and cordyceps makes the dried ginger formula granules have the properties of improving the stability of the granules, and the warming and tonic properties of the medicinal materials can also improve the immunity of people with weak and cold constitutions. BRIEF DESCRIPTION OF THE DRAWINGS
[0016] Figure 1 A flow chart is prepared for the present invention; DETAILED DESCRIPTION
[0017] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.
[0018] See also Figure 1 , a compound dried ginger formula granule and a preparation method thereof, the raw material components and their functions include: Dry ginger extract: warms the middle and dispels cold; Atractylodes macrocephala: invigorates the spleen and dries dampness, harmonizes the stomach and stops vomiting; Licorice: replenishes Qi, tonifies the middle, clears away heat and detoxifies; Dendrobium extract: nourishes yin, clears away heat, promotes fluid production and quenches thirst; Angelica: replenishes blood and regulates menstruation, relieves pain, moisturizes and promotes bowel movements; Deer antler: nourishes the kidney and strengthens yang, improves essence and blood, and strengthens tendons and bones; Ginseng: greatly replenishes vital energy, restores pulse and strengthens looseness, promotes fluid production and quenches thirst, calms the mind and improves intelligence; Aconite extract: warms the meridians and dispels cold, restores the pulse and consolidates the body; Cordyceps: nourishes the lungs and kidneys, relieves cough and resolves phlegm; Bulking agent: used to increase the weight and volume of dried ginger granules, making them easier to produce and store; Disintegrant: helps the dried ginger particles to disperse and be absorbed quickly in the body; Wetting agent: Increase the moisture content of dried ginger particles, making them easier to produce and store; The weight parts of the raw material components are: 30-33 parts of dried ginger extract; 3-6 parts of Atractylodes macrocephala; 5-9 parts of licorice; 4-7 parts of Dendrobium extract; 1-3 parts of Angelica sinensis; 0.75-1.00 parts of pilose antler; 1-3 parts of ginseng; 7-11 parts of aconite extract; 0.2-0.7 parts of cordyceps; 12-14 parts of filler; 0.2-0.6 parts of disintegrant; 0.4-0.7 parts of wetting agent.
[0019] The preparation process of dried ginger extract is as follows: S1.1. Raw material preparation: Wash, slice, dry and dry ginger. After turning into dried ginger, use an ultrafine grinder to grind the dried ginger into dried ginger powder with a particle size of 1mm-1.2mm; S1.2, Equipment selection and parameter setting: Use SFE-2 supercritical CO2 fluid extractor, set the extraction temperature to 35℃, set the extraction pressure to 20 MPa, and set the extraction time to 1h. This temperature and extraction time can ensure that the heat-sensitive components are not destroyed and retain the original activity of dried ginger; S1.3, Extraction process: put the dried ginger powder into the extraction tank, add 150% supercritical CO2 of the dried ginger powder as the solvent, turn on the SFE-2 supercritical CO2 fluid extractor for extraction. During this process, CO2 will dissolve and extract the effective ingredients in the dried ginger. After the extraction is completed, the CO2 is released by reducing the pressure, thereby separating the dried ginger oil and other volatile components.
[0020] The preparation process of Dendrobium officinale extract is as follows: S2.1, pretreatment: wash the raw materials of Dendrobium to remove impurities and microorganisms on the surface; S2.2, crushing: crushing the washed dendrobium raw material into coarse powder using a blade crusher to increase its surface area in contact with the solvent and improve the extraction efficiency; S2.3, extraction: use 75% ethanol for extraction, add the crude powder of dendrobium to 150% ethanol by weight of the crude powder of dendrobium to form a mixed solution, use a centrifuge to centrifuge the mixed solution at a speed of 1000 rpm for 30 minutes, let it stand for 3 hours, and then take the supernatant. Ethanol as a solvent can effectively extract the active ingredients from the dendrobium and facilitate subsequent processing.
[0021] The preparation process of Aconite extract is as follows: S3.1, selection and cleaning: select pest-free and pollution-free raw materials of aconite extract, and clean them to remove impurities and dirt on the surface; S3.2, cutting and crushing: the washed aconite extract is cut into pieces of 0.5 cm to 0.8 cm using a cutting machine to increase its surface area in contact with the extraction solvent, thereby improving the extraction efficiency; S3.3. Extraction: Mix the cut aconite extract with water in a ratio of 1:3, and extract by ultrasonic extraction. Set the extraction time to 1 hour and the extraction temperature to 45°C to ensure sufficient extraction of the active ingredients.
[0022] S3.4, Filtration: After extraction, the mixture was centrifuged at 200 rpm for 30 min, and after standing for 1.5 h, the supernatant and the residue were separated to separate the solid residue and the liquid extract; S3.5. Concentration: The separated supernatant is evaporated at a constant temperature of 100° C. to be concentrated to 1 / 10 of the original volume to reduce the volume and increase the concentration of the extract.
[0023] A method for preparing compound dried ginger formula granules, comprising the following steps: Step 1: Pretreatment: Clean and crush all medicinal materials to remove surface impurities and microorganisms; Step 2, extraction and grinding: extracting and grinding the raw materials; Step 3, weighing: weighing dried ginger extract, Atractylodes macrocephala, licorice, dendrobium extract, angelica, pilose antler, ginseng, aconite extract, cordyceps, filler, disintegrant and wetting agent according to the formula ratio; Step 4: Mix the raw material extracts in order, then add the raw material powder to ensure the consistency of the medicinal ingredients in each granule; Step 5: Granulation: The mixture is made into granules by dry granulation technology; Step 6: Drying: Dry the granules to remove excess water and ensure the stability and shelf life of the granules; Step 7: Packaging: Finally, the dried particles are sealed and packaged and stored in a cool and dry environment to ensure their quality and safety; Step 8. Content testing: Determine the content of the final product to ensure that each ingredient meets the preset standards; Step 9. Activity detection and stability test: Conduct activity detection and stability test to ensure that the dried ginger formula granules remain effective within the shelf life.
[0024] Step 2: Extraction and grinding: subject the raw materials of ginger, dendrobium and aconite to supercritical CO2 fluid extraction, ethanol extraction and water extraction respectively to obtain dried ginger extract, dendrobium extract and aconite extract; grind atractylodes, licorice, angelica, pilose antler, ginseng and cordyceps into powders of 60 to 100 microns using an ultrafine grinder for later use.
[0025] The mixing process of the raw material extracts in step 4 is as follows: first add the dried ginger extract, heat at 60°C for 2 minutes, then add the aconite extract, heat at 55°C for 3 minutes, and finally lower the temperature to 40°C, add the dendrobium extract and heat for 8 minutes.
[0026] In step 4, the raw material grinding and powder mixing process is as follows: first add angelica and ginseng, heat at 50°C for 1 min, then add atractylodes and pilose antler, heat at 35°C for 30s, finally lower the temperature to 40°C, add licorice and cordyceps and heat for 1 min.
[0027] The dry granulation process in step 5 is: S4.1, mixing: uniformly mixing the mixed medicinal material particles in step 4 with the filler, disintegrant, and wetting agent to prepare a homogeneous powder mixture; S4.2, dry granulation: using a dry granulator to mechanically squeeze the powder mixture into a plate-like material; S4.3. Granulation: The pressed plate-like material is crushed and sieved to obtain particles within the particle size range required by the manufacturer. The prepared particles are vacuum-packed in sterile medical packaging bags to prepare the final pharmaceutical dosage form.
[0028] The drying conditions in step six are: in a sterile oven, set the oven temperature to 80°C and set the drying time to 40 minutes.
[0029] Example 1 The raw material components are as follows by weight: 30 parts of dried ginger extract; 5 parts of atractylodes macrocephala; 8 parts of licorice; 6 parts of dendrobium extract; 1.5 parts of angelica; 0.75 parts of pilose antler; 2 parts of ginseng; 8 parts of aconite extract; 0.6 parts of cordyceps; 12 parts of filler; 0.3 parts of disintegrant; 0.4 parts of wetting agent, and the dried ginger formula granules are prepared according to the preparation process of the present invention.
[0030] Example 2 The weight parts of the raw material components are: 33 parts of dried ginger extract; 6 parts of Atractylodes macrocephala; 9 parts of licorice; 4 parts of dendrobium extract; 1 part of angelica; 1.00 parts of pilose antler; 3 parts of ginseng; 12 parts of aconite extract; 0.6 parts of cordyceps; 13 parts of filler; 0.5 parts of disintegrant; and 0.7 parts of wetting agent.
[0031] Comparative Example 1 The raw material components are as follows by weight: 30 parts of dried ginger extract; 5 parts of Atractylodes macrocephala; 8 parts of licorice; 6 parts of dendrobium extract; 1.5 parts of angelica; 0.75 parts of pilose antler; 2 parts of ginseng; 8 parts of aconite extract; 0.6 parts of cordyceps; 12 parts of filler; 0.3 parts of disintegrant; 0.4 parts of wetting agent, and the ginger paste is made according to the traditional preparation process.
[0032] Comparative Example 2 The Dendrobium extract in Example 2 is replaced with Houttuynia cordata extract, and the Aconite extract and Cordyceps in Example 2 are removed. The weight parts of the raw material components are: 33 parts of dried ginger extract; 6 parts of Atractylodes macrocephala; 9 parts of Licorice; 4 parts of Houttuynia cordata extract; 1 part of Angelica sinensis; 1.00 parts of pilose antler; 3 parts of ginseng; 13 parts of filler; 0.5 parts of disintegrant; and 0.7 parts of wetting agent.
[0033] The laboratory made Example 1-2 and Comparative Example 1-2 into finished products, and conducted content detection, activity detection and stability test, and made the following table based on the functional feedback of the trial population:
[0034] Comparison between Example 1 and Comparative Example 1: Example 1 showed high activity in the activity test, while Comparative Example 1 showed low activity. In terms of feedback from the trial population, 98% of the trial users reported that Example 1 had a significant effect, while only 20% of the trial users reported that Comparative Example 1 was effective, and 80% reported that it was ineffective. This indicates that the preparation process of the present invention may more effectively retain the active ingredients of the raw materials, thereby improving the overall effect of the product.
[0035] Comparison of Example 2 with Comparative Example 2: Example 2 showed high activity in the activity test, while Comparative Example 2 showed low activity. In the stability test, Example 2 showed excellent stability, while Comparative Example 2 was unstable and easily decomposed. In terms of feedback from the trial population, 99% of the trial population reported that Example 2 was effective, while only 8% of the trial population reported that Comparative Example 2 was effective, and 92% reported that it was ineffective. This shows that the combination of Dendrobium extract, Aconitum extract and Cordyceps sinensis helps to improve the stability of the dried ginger formula granules while improving the immunity of people with weak and cold constitutions.
[0036] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.
Claims
1. A compound dried ginger formula granule, characterized in that: Its raw material ingredients include: dried ginger extract, white atractylodes, liquorice, dendrobium extract, angelica, deer antler, ginseng, aconite extract, cordyceps, fillers, disintegrants and wetting agents; The raw material components are as follows: 30-33 parts of dried ginger extract; 3-6 parts of white atractylodes; 5-9 parts of liquorice; 4-7 parts of dendrobium extract; 1-3 parts of angelica; 0.75-1.00 parts of pilose antler; 1-3 parts of ginseng; 7-11 parts of aconite extract; 0.2-0.7 parts of cordyceps; 12-14 parts of filler; 0.2-0.6 parts of disintegrant; 0.4-0.7 parts of wetting agent.
2. The compound dried ginger formula granules according to claim 1, characterized in that: The preparation process of the dried ginger extract is as follows: S1.
1. Raw material preparation: Wash, slice, dry and dry ginger. After turning into dried ginger, use an ultrafine grinder to grind the dried ginger into dried ginger powder with a particle size of 1mm-1.2mm; S1.
2. Equipment selection and parameter setting: Use SFE-2 supercritical CO2 fluid extractor, set the extraction temperature to 35°C, set the extraction pressure to 20 MPa, and set the extraction time to 1h; S1.3, Extraction process: put the dried ginger powder into the extraction tank, add 150% supercritical CO2 of the dried ginger powder as solvent, and start the SFE-2 supercritical CO2 fluid extractor for extraction.
3. The compound dried ginger formula granules according to claim 1, characterized in that: The preparation process of the dendrobium extract is as follows: S2.1, pretreatment: washing the raw materials of Dendrobium; S2.2, crushing: crushing the washed dendrobium raw material into dendrobium coarse powder using a blade crusher; S2.3, extraction: use 75% ethanol for extraction, add the crude powder of dendrobium to 150% ethanol by weight of the crude powder of dendrobium to form a mixed solution, use a centrifuge to centrifuge the mixed solution at a speed of 1000 rpm for 30 minutes, let it stand for 3 hours, and then take the supernatant.
4. The compound dried ginger formula granules according to claim 1, characterized in that: The preparation process of the aconite extract is as follows: S3.
1. Selection and cleaning: Select pest-free and pollution-free raw materials of aconite extract and clean them; S3.2, cutting and crushing: using a cutting machine to cut the washed aconite extract into pieces of 0.5 cm-0.8 cm; S3.3, Extraction: Mix the cut aconite extract with water in a ratio of 1:3, extract by ultrasonic extraction, set the extraction time to 1h, and set the extraction temperature to 45°C; S3.4, Filtration: After extraction, the mixture was centrifuged at 200 rpm for 30 min, and after standing for 1.5 h, the supernatant and the residue were separated; S3.
5. Concentration: The separated supernatant is evaporated at a constant temperature of 100°C to concentrate it to 1 / 10 of its original volume.
5. A method for preparing compound dried ginger formula granules, characterized in that: The preparation of the dried ginger formula granules according to claim 1 comprises the following steps: Step 1: Pretreatment: Clean and crush all medicinal materials; Step 2, extraction and grinding: extracting and grinding the raw materials; Step 3, weighing: weighing dried ginger extract, Atractylodes macrocephala, licorice, dendrobium extract, angelica, pilose antler, ginseng, aconite extract, cordyceps, filler, disintegrant and wetting agent according to the formula ratio; Step 4: Mix the raw material extracts in order, and then add the raw material powder; Step 5: Granulation: The mixture is made into granules by dry granulation technology; Step 6: Drying: Dry the particles prepared in step 5; Step 7: Packaging: Finally, the dried particles are sealed and packaged; Step 8. Content detection: Determine the content of the final product; Step 9. Activity detection and stability test: Conduct activity detection and stability test.
6. The method for preparing the compound dried ginger formula granules according to claim 5, characterized in that: Extraction and grinding in step 2: ginger, dendrobium and aconite raw materials are subjected to supercritical CO2 fluid extraction, ethanol extraction and water extraction respectively to obtain dried ginger extract, dendrobium extract and aconite extract; white atractylodes, licorice, angelica, pilose antler, ginseng and cordyceps are ground into powders of 60 microns to 100 microns using ultrafine grinders.
7. The method for preparing the compound dried ginger formula granules according to claim 5, characterized in that: The mixing process of the raw material extracts in step 4 is: first add the dried ginger extract, heat at 60°C for 2 minutes, then add the aconite extract, heat at 55°C for 3 minutes, and finally reduce the temperature to 40°C, add the dendrobium extract and heat for 8 minutes.
8. The method for preparing the compound dried ginger formula granules according to claim 5, characterized in that: The raw material grinding powder mixing process in step 4 is as follows: first add angelica and ginseng, heat at 50°C for 1 minute, then add atractylodes and pilose antler, heat at 35°C for 30 seconds, finally reduce the temperature to 40°C, add licorice and cordyceps and heat for 1 minute.
9. The method for preparing the compound dried ginger formula granules according to claim 5, characterized in that: The dry granulation process in step 5 is as follows: S4.1, mixing: uniformly mixing the mixed medicinal material particles in step 4 with the filler, disintegrant and wetting agent; S4.2, dry granulation: using a dry granulator to mechanically squeeze the powder mixture into a plate-like material; S4.
3. Granulation: The pressed plate-like material is crushed and sieved to obtain particles within the particle size range required by the manufacturer. The prepared particles are vacuum-packed in sterile medical packaging bags.
10. The method for preparing the compound dried ginger formula granules according to claim 5, characterized in that: The drying conditions in step 6 are as follows: the particles are placed in a sterile oven, the oven temperature is set to 80° C., and the drying time is set to 40 min.