Antifouling developing coating material as well as preparation method and application thereof

Abstract

The invention provides an antifouling developing coating material and a preparation method and application thereof.The antifouling developing coating material is of a structure shown in the formula I. The antifouling developing coating material combines antifouling and developing through a covalent binding technology, has excellent antifouling performance and developing performance, and can be applied to the field of chemical engineering. According to the invention, the stability and durability of the developing effect can be ensured, the safety is good, the application range is wider, and powerful support is provided for the safety of medical equipment and the accuracy of medical images.

Description

Technical Field

[0001] The invention belongs to the technical field of medical materials and relates to an anti-fouling developing coating material and a preparation method and application thereof. Background Art

[0002] Medical developer coatings are crucial in medical imaging. With the continuous development of medical imaging, the requirements for developer coatings are increasing. In addition to having excellent developer functions, they also need to have excellent antifouling properties to resist the adhesion of bacteria and proteins, prevent infection, and keep the surface clean and transparent, thereby ensuring clear and accurate images.

[0003] The development of medical antifouling developer coatings stems from the improvement of traditional developer coatings. Although traditional developer coatings can provide developer functions, their antifouling performance is limited. With the increasing use of medical devices, scientists urgently need to study the addition of antifouling materials to improve antifouling performance. The antifouling principle mainly includes the hydrophilicity and hydrophobicity of the material surface. The hydrophilic surface can form a larger water contact angle to prevent the retention of water and impurities, while the hydrophobic surface can prevent the attachment of organic matter or oil and reduce the adsorption of biological molecules.

[0004] In recent years, research on medical antifouling coatings has made significant progress. Excellent antifouling coatings have been developed by adjusting the surface properties. For example, the introduction of super-hydrophobic polymer materials makes the surface super-hydrophobic, achieving efficient self-cleaning and anti-fouling. At the same time, special surface structures such as micro-nano concave-convex and honeycomb are designed through bionics to reduce the surface contact area and reduce the attachment of pollutants. In addition, embedding bioactive molecules into the coating to form a "sterilization circle" can inhibit the reproduction of microorganisms and improve the anti-fouling effect.

[0005] The developing performance of medical antifouling developing coatings has a crucial impact on the clarity and diagnostic accuracy of medical images. Such coatings need to be sensitive to X-rays to ensure good developing effects under X-ray irradiation. Development technology is widely used in medical imaging to generate clear images through the development of image-sensitive materials. Among them, X-ray development is a common technology that relies on the absorption and scattering of X-rays, and the developing coating plays a key role in this process, forming images by absorbing and scattering X-rays.

[0006] Nevertheless, the interaction between the developer and the antifouling agent may reduce the development efficiency. Therefore, how to effectively combine the development and antifouling functions is still a challenging problem that needs to be further solved. Summary of the invention

[0007] In view of the deficiencies in the prior art, the object of the present invention is to provide an anti-fouling developing coating material and a preparation method and application thereof.

[0008] In order to achieve the purpose of the invention, the present invention adopts the following technical solutions:

[0009] In one aspect, the present invention provides an anti-fouling developing coating material, wherein the anti-fouling developing coating material has a structure as shown in the following formula I:

[0010]

[0011] wherein m=1-40 (e.g., 1, 2, 3, 5, 8, 10, 13, 15, 18, 20, 22, 25, 28, 30, 32, 34, 36, 38 or 40, etc.), n=1-40 (e.g., 1, 2, 3, 5, 8, 10, 13, 15, 18, 20, 22, 25, 28, 30, 32, 34, 36, 38 or 40, etc.), k=1-4 (e.g., 1, 2, 3 or 4), R1 is hydrogen or methyl, R2 is a single bond, a C1-C8 (e.g., C1, C2, C3, C4, C5, C6, C7 or C8) alkyl or R4 is C1-C5 (e.g., C1, C2, C3, C4, or C5) alkyl, R3 is C1-C5 (e.g., C1, C2, C3, C4, or C5) alkyl or -O-Si-R5, R5 is C1-C5 (e.g., C1, C2, C3, C4, or C5) alkyl; R is hydroxy or The wavy line represents the attachment site of the group.

[0012] In the present invention, the antifouling and developing coating material covalently bonds phosphorylcholine, siloxane and developing monomers through a polymerization reaction, so that the obtained material combines antifouling and developing, ensures the stability of the material, ensures the stability of the antifouling and developing properties, and makes the material have outstanding performance in both antifouling performance and developing effect, so that it has broad application prospects in the field of medical imaging, and provides strong support for the safety of medical equipment and the accuracy of medical images.

[0013] In some preferred embodiments, m:n=1:1-4:1, such as 1:1, 2:1, 3:1 or 4:1.

[0014] In the present invention, m, n and k represent the number of structural units, wherein R in k structural units may be the same or different.

[0015] Preferably, the anti-fouling developing coating material is any one of the compounds having structures shown in the following formula II to formula IV:

[0016]

[0017]

[0018] wherein m, n, k and R are defined in the same manner as in Formula I.

[0019] On the other hand, the present invention provides a method for preparing the novel anti-fouling developing coating material as described above, the preparation method comprising the following steps:

[0020] (1) The hydrolyzate of iohexol is reacted with 2-isocyanatoethyl acrylate to obtain the developing monomer described in Formula II. The reaction formula is as follows:

[0021]

[0022] (2) 2-methacryloyloxyethyl phosphorylcholine reacts with the developing monomer of formula II and the siloxane compound of formula A to obtain the antifouling developing coating material of formula I. The reaction formula is as follows:

[0023]

[0024] Where R is hydroxyl or

[0025] Preferably, the reaction in step (1) is carried out in the presence of a catalyst;

[0026] Preferably, the catalyst is any one of dibutyltin dilaurate, ethylenediamine, polyethyleneimine, triethylenediamine or bis(2-dimethylaminoethyl)ether, or a combination of at least two thereof.

[0027] Preferably, the molar ratio of the iohexol hydrolyzate to 2-isocyanatoethyl acrylate is 1:1 to 1:4; for example, 1:1, 1:1.5, 1:2, 1:2.5, 1:3, 1:3.5 or 1:4.

[0028] Preferably, the reaction temperature in step (1) is 30-50°C (e.g., 30°C, 35°C, 38°C, 40°C, 43°C, 45°C, 48°C or 50°C), and the reaction time is 24-48h (e.g., 24h, 28h, 30h, 33h, 35h, 38h, 40h, 42h, 46h or 48h).

[0029] Preferably, the solvent for the reaction in step (1) is any one of N,N-dimethylformamide, isopropanol, methanol, diethyl ether or ethyl acetate, or a combination of at least two thereof.

[0030] Preferably, the reaction in step (1) is carried out under nitrogen protection.

[0031] Preferably, the siloxane compound in step (2) is methacryloxypropyl tris(trimethylsiloxy)silane, methacryloxypropyl tris(trimethoxy)silane or vinyl trimethoxysilane;

[0032] Preferably, the molar ratio of the 2-methacryloyloxyethyl phosphorylcholine to the siloxane compound in step (2) is 1:1-8:1; for example, 1:1, 1.5:1, 2:1, 2.5:1, 3:1, 3.5:1, 4:1, 4.5:1, 5:1, 5.5:1, 6:1, 6.5:1, 7:1, 7.5:1 or 8:1.

[0033] Preferably, the molar ratio of the siloxane-modified modified phosphorylcholine polymer in step (2) to the developing monomer of formula II is 2:1-8:1, for example 2:1, 2.3:1, 2.5:1, 2.8:1, 3:1, 3.5:1, 4:1, 4.5:1, 5:1, 5.5:1, 6:1, 6.5:1, 7:1, 7.5:1 or 8:1.

[0034] Preferably, the reaction in step (2) is carried out in the presence of 4-cyano-4-(thiobenzoyl)pentanoic acid;

[0035] Preferably, the molar ratio of 2-methacryloyloxyethyl phosphorylcholine to 4-cyano-4-(thiobenzoyl)pentanoic acid in step (2) is 1:1-5:1, for example 1:1, 1.5:1, 2:1, 2.5:1, 3:1, 3.5:1, 4:1, 4.5:1 or 5:1.

[0036] Preferably, the reaction in step (2) is carried out in the presence of an initiator;

[0037] Preferably, the initiator is selected from azobisisobutyronitrile;

[0038] Preferably, the molar ratio of the 2-methacryloyloxyethyl phosphorylcholine to the initiator is 1:1-5:1, for example 1:1, 1.5:1, 2:1, 2.5:1, 3:1, 3.5:1, 4:1, 4.5:1 or 5:1.

[0039] Preferably, the reaction temperature in step (2) is 60°C-70°C (e.g., 60°C, 63°C, 65°C, 68°C or 70°C), and the reaction time is 16-64h (e.g., 16h, 18h, 20h, 24h, 28h, 30h, 36h, 40h, 42h, 48h, 50h, 55h, 58h, 60h or 64h).

[0040] Preferably, after the reaction in step (2) is completed, a post-treatment step is further included, wherein the post-treatment step is to precipitate the obtained reaction solution in ether, filter and dry.

[0041] In another aspect, the present invention provides the use of the novel antifouling developing coating material as described above in coating a substrate surface.

[0042] Preferably, the substrate surface includes a silicon-based surface, a glass-based surface, a metal-based surface, or a high-molecular polymer-based surface.

[0043] The antifouling developing coating material of the present invention can be applied to the surfaces of various substrates, including glass substrates, metal substrates and various plastic and high molecular polymer substrates (silicone rubber, polyethylene, polypropylene, polyvinyl chloride, polystyrene, polyurethane, etc.).

[0044] The anti-fouling developing coating material of the present invention has universal applicability. It can be covalently bonded to any silicon-based substrate by combining with the hydroxyl groups on the surface of the substrate through silicon-oxygen bonds, including various silicon-based surfaces such as glass, silicone sheets, and marble. It can be combined with other substrate surfaces through hydrophobic effects or van der Waals forces, and is widely applicable to different clinical and laboratory scenarios to meet the needs of different users.

[0045] In another aspect, the present invention provides an anti-fouling developing coating, wherein the raw materials for preparing the anti-fouling developing coating include the anti-fouling developing coating material as described above.

[0046] In another aspect, the present invention provides use of the antifouling developing coating material as described above in medical devices or medical materials, optical lenses or industrial printing.

[0047] Compared with the prior art, the present invention has the following beneficial effects:

[0048] First of all, the antifouling developer coating material of the present invention has been successfully applied to medical devices to form a coating with excellent antifouling properties. Compared with traditional developer coatings, this material has achieved significant improvement in antifouling. Its uniqueness lies in containing modified phosphorylcholine polymer as an antifouling agent component, which can effectively resist the attachment of bacteria and proteins, and prevent bacterial infection and cross infection. This feature is crucial for medical safety, ensuring that medical equipment remains hygienic and safe during use. This material is suitable for various medical scenarios, especially in high-sanitation standard equipment such as operating rooms and medical catheters.

[0049] In addition, the antifouling developing coating material of the present invention exhibits an excellent developing effect. Compared with the traditional method, the coating is in the form of a water-insoluble elastomer and will not be lost during the human body's metabolism, ensuring the stability and durability of the developing effect, thereby eliminating the side effects that may be caused by the developing coating and improving the safety of the medical developing coating, which has positive significance for the patient's health and medical experience.

[0050] The antifouling developing coating material of the present invention also has a wide range of applicability. It can be covalently bonded to various silicon-based surfaces including glass, silicone sheets, marble, etc. by combining with the hydroxyl groups on the surface of the substrate through silicon-oxygen bonds. It is combined with other substrate surfaces through hydrophobic effects or van der Waals forces, making it widely applicable to different clinical and laboratory scenarios to meet the needs of various users. Compared with traditional coatings, its preparation method is simpler and the cost is lower, providing a feasible way for the large-scale application of developing coatings. BRIEF DESCRIPTION OF THE DRAWINGS

[0051] Figure 1 This is the NMR data of the developer monomer.

[0052] Figure 2 This is the H-NMR spectrum of the polymer prepared in Example 1.

[0053] Figure 3 This is the H-NMR spectrum of the polymer prepared in Example 2.

[0054] Figure 4 This is a diagram showing the anti-coagulation effect of the new anti-fouling developing coating material.

[0055] Figure 5A A fluorescence microscope photograph of the anti-protein adhesion test result of the novel anti-fouling developing coating material of the present invention;

[0056] Figure 5B A fluorescence quantitative analysis result diagram of the total amount of protein molecules adsorbed by the novel antifouling developing coating material of the present invention;

[0057] Fig. 6A This is a result diagram of the anti-bacterial adhesion test of the novel anti-fouling developing coating material of the present invention;

[0058] Figure 6B This is a quantitative analysis result diagram of the anti-bacterial adhesion test of the novel anti-fouling developing coating material of the present invention;

[0059] Fig. 7A This is a picture showing the development test results of the new antifouling development coating inside a rat;

[0060] Figure 7B This is a quantitative analysis result of the development of the new anti-fouling development coating inside rat tissue. DETAILED DESCRIPTION

[0061] The technical solution of the present invention is further described below by specific implementation methods. It should be understood by those skilled in the art that the embodiments are only to help understand the present invention and should not be regarded as specific limitations of the present invention.

[0062] Example 1

[0063] This embodiment provides an anti-fouling developing coating material, which is prepared by a method comprising the following steps:

[0064] (1) Preparation of developer monomer:

[0065]

[0066] Take 1.34mmol of iohexol hydrolyzate in 20mL of ultra-dry DMF, stir until suspended, add two drops of catalyst DBTL and 5.36mmol of 2-isocyanatoethyl acrylate respectively, stir magnetically, and react at 30℃ for 24h. Add 1mL of ethanol to quench the reaction, pour the reaction solution into 200mL of ether, and a white precipitate will appear. Let it stand until the upper and lower layers are separated, absorb the upper clear liquid, evaporate the ether at room temperature or dry in a vacuum oven at room temperature to obtain the developing monomer product. The NMR results are as follows: Figure 1 shown.

[0067] 2) Preparation of antifouling developing coating material:

[0068]

[0069] Where R is

[0070] 0.75 mol of 2-methacryloyloxyethyl phosphorylcholine, 0.4 mol of 4-cyano-4-(thiobenzoyl)valeric acid, and 0.4 mol of azobisisobutyronitrile were dissolved in n-propanol, and the temperature was slowly raised to 65°C under nitrogen protection, and stirred for reaction for 24 hours. Then, 0.125 mol of methacryloyloxypropyl tris(trimethylsiloxy)silane and 0.075 mol of developing monomer were added, and the reaction was continued for 24 hours. The obtained n-propanol solution was added to ether for precipitation, and filtered and dried to obtain a modified phosphorylcholine polymer. The obtained polymer NMR was as follows: Figure 2 As shown, a peak of trimethylsiloxane was detected at 3.55 ppm.

[0071] Example 2

[0072] This embodiment provides an anti-fouling developing coating material, which is prepared by a method comprising the following steps: the preparation of the developing monomer is the same as in Embodiment 1.

[0073] 0.75 mol of 2-methacryloyloxyethyl phosphorylcholine, 0.4 mol of 4-cyano-4-(thiobenzoyl)valeric acid, and 0.4 mol of azobisisobutyronitrile were dissolved in n-propanol, and the temperature was slowly raised to 60°C under nitrogen protection, and stirred for reaction for 24 hours. Then, 0.125 mol of 3-(triethoxysilyl) propyl methacrylate and 0.075 mol of developing monomer were added, and the reaction was continued for 24 hours. The obtained n-propanol solution was added to ether for precipitation, and filtered and dried to obtain a modified phosphorylcholine polymer. The obtained polymer NMR was as follows: Figure 3 As shown, a peak of methoxysilane was detected at 3.55 ppm.

[0074] Example 3

[0075] The anti-fouling developing coating material obtained in Example 1 of the present invention was used to test the anti-coagulation effect. In terms of anti-coagulation, the adsorption capacity of rat whole blood on the anti-fouling developing coating was measured and characterized. The anti-fouling developing coating solution was prepared by dissolving the anti-fouling developing coating material in DMF at a concentration of 300 mg / mL. The solution was used to coat a silicone hose and solidified in an oven at 60°C. The silicone hose coated with the anti-fouling developing coating was immersed in freshly taken rat whole blood, taken out after five minutes, and rinsed three times with physiological saline. The control group was a blank control without the anti-fouling developing coating. The results are shown in FIG. Figure 4 shown.

[0076] like Figure 4 As shown in the figure, the coating exhibits excellent anti-coagulation ability compared to the blank control. Blood is hardly adsorbed on the coating, while the blank control group is full of whole blood adsorbed on it.

[0077] Example 4

[0078] The anti-fouling developing coating material of Example 1 was used to carry out an anti-protein adhesion test.

[0079] In terms of anti-protein adsorption, the adsorption capacity of fibrin (FIB), serum protein (HB) and collagen (Col) on the anti-fouling developing coating was measured and characterized.

[0080] The protein molecules were pre-labeled with fluorescent markers and subjected to 21-day adsorption experiments. On the 3rd, 14th and 21st days, the adsorption of various molecules on the coating was observed using a fluorescence microscope (Nikon Eclipse TE / Ti). The control group was a blank control without antifouling developing coating. The results are shown in Figure 2. Figure 5A and Figure 5B shown.

[0081] like Figure 5AAs shown in the figure, the coating exhibits excellent anti-protein adsorption ability compared with the blank control. Serum protein is hardly adsorbed on the coating, and the amount of fibrin adsorbed on the anti-fouling developing coating is also very small, while the blank control group is full of protein molecules adsorbed on it. Furthermore, the total amount of adsorbed molecules was quantitatively analyzed by fluorescence, as shown in Figure 2. Figure 5B As shown, compared with the blank control group, the total amount of protein adsorbed on the anti-fouling developing coating was significantly reduced, demonstrating the extremely strong anti-protein adsorption ability of the anti-fouling developing coating.

[0082] Example 5

[0083] The anti-fouling developing coating material of Example 1 was used to conduct an anti-bacterial adhesion test.

[0084] In terms of anti-bacterial adhesion, the anti-bacterial adsorption ability of the anti-fouling developing coating was characterized and tested using Candida albicans (C.albicans), Escherichia coli (E.coli) and Staphylococcus aureus (S.aureus). The samples were immersed in a high concentration (10 8 The live bacteria were replaced once a day in three kinds of live bacterial solutions (1000 cells / mL). After soaking for one week, the live bacteria were taken out and dried. The number of bacteria on them was observed using a scanning electron microscope (SEM, Japan Hitachi; S-3400N). The solvent was dialysate to ensure bacterial activity, and the control group was a blank control. The results are shown in Figure 2. Fig. 6A and Figure 6B shown.

[0085] like Fig. 6A As shown in the figure, under the adsorption of three different bacteria, after one week, there were obvious large colonies on the control group without antifouling developing coating, while no obvious colony growth was observed on the sample coated with antifouling developing coating. Further, the adsorbed colonies were quantitatively analyzed, and the results are shown in Figure 6B As shown, the samples using the antifouling developer coating showed a significant reduction in bacterial adhesion, with the amount of bacterial adhesion reduced by 90% after one week.

[0086] Example 6

[0087] The antifouling developing coating material of Example 1 was used to perform an X-ray development test. The antifouling developing coating material of the present invention was coated on a silicone hose and placed in a rat body. The coating concentration (solution concentration) was 100 mg / mL and 200 mg / mL. The uncoated group was used as a control. A medical X-ray irradiator (manufacturer: Frameview Dexin; model: XVS2530) was used to take photos. The results are as follows: Fig. 7A and Figure 7B As shown, Fig. 7A It is X-ray development pictures of development materials with different concentrations; Figure 7Bis the gray value of the developer material at different concentrations; it can be seen that the development effect of the antifouling developer coating material of the present invention is much higher than that of the blank control group. Through quantitative analysis of the development part by ImageJ software, it can be found that the development intensity inside the rat increases with the increase of concentration. It can be seen that the antifouling developer coating material of the present invention has a strong X-ray development effect.

[0088] It can be seen from the above that the antifouling and developing coating material of the present invention has excellent coating performance, antifouling performance and X-ray developing effect.

[0089] The modified phosphorylcholine polymer part in the antifouling developing coating material of the present invention serves as an antifouling unit, and the combined iohexol serves as a developing unit, and the antifouling and developing properties are excellent. The siloxane group in the antifouling unit can form a covalent bond with the substrate surface so that the coating is firmly combined with the substrate, ensuring the binding stability and safety of the antifouling developing coating material of the present invention on the substrate. For example, the siloxane group can be covalently combined with the silicon-based substrate material, has excellent stability, will not be lost or fall off over time, and significantly improves the durability and reliability of the developing coating; the siloxane group can also be combined with other substrate surfaces through hydrophobic effects and van der Waals forces, thereby providing flexibility and applicability for the wide application of the developing coating. The antifouling developing coating material of the present invention can be coated on the surfaces of various substrates, including silicon-based substrates (such as glass substrates), metal substrates, and various plastic and high molecular polymer substrates (such as silicone rubber, polyethylene, polypropylene, polyvinyl chloride, polystyrene, polyurethane, etc.), and has wide applicability; the application fields are wide, for example, it can be used in the fields of medical devices, optical lenses and industrial printing. The coating gives the coated object the dual functions of antifouling and X-ray imaging, and exhibits excellent X-ray absorption performance during development, especially can provide accurate and clear development effects for medical imaging, and provide reliable imaging information for medical imaging.

[0090] The applicant declares that the present invention uses the above-mentioned embodiments to illustrate the anti-fouling developing coating material and its application, but the present invention is not limited to the above-mentioned embodiments, that is, it does not mean that the present invention must rely on the above-mentioned embodiments to be implemented. Those skilled in the art should understand that any improvement of the present invention, equivalent replacement of the raw materials selected by the present invention, addition of auxiliary components, selection of specific methods, etc., all fall within the protection scope and disclosure scope of the present invention.

Claims

1. An antifouling developing coating material, characterized in that: The anti-fouling developing coating material has a structure as shown in the following formula I: Wherein m=1-40, n=1-40, k=1-4, R1 is hydrogen or methyl, R2 is a single bond, C1-C8 alkyl or R4 is a C1-C5 alkyl group, R3 is a C1-C5 alkyl group or -O-Si-R5, R5 is a C1-C5 alkyl group; R is a hydroxyl group or The wavy line represents the attachment site of the group.

2. The antifouling developing coating material according to claim 1, characterized in that: m:n=1:1~4:

1.

3. The antifouling developing coating material according to claim 1, characterized in that: The anti-fouling developing coating material is any one of the compounds shown in the following formula II to formula IV: wherein m, n, k and R are defined in the same manner as in Formula I.

4. The method for preparing an antifouling developing coating material according to any one of claims 1 to 3, characterized in that: The preparation method comprises the following steps: (1) The hydrolyzate of iohexol is reacted with 2-isocyanatoethyl acrylate to obtain the developing monomer described in Formula II. The reaction formula is as follows: (2) 2-methacryloyloxyethyl phosphorylcholine reacts with the developing monomer of formula II and the siloxane compound of formula A to obtain the antifouling developing coating material of formula I. The reaction formula is as follows: Where R is hydroxyl or 5. The preparation method according to claim 4, characterized in that: The reaction in step (1) is carried out in the presence of a catalyst; Preferably, the catalyst is any one of dibutyltin dilaurate, ethylenediamine, polyethyleneimine, triethylenediamine or bis(2-dimethylaminoethyl)ether or a combination of at least two thereof; Preferably, the molar ratio of the iohexol hydrolyzate to 2-isocyanatoethyl acrylate is 1:1 to 1:4; Preferably, the reaction temperature in step (1) is 30-50°C and the reaction time is 24-48h; Preferably, the solvent for the reaction in step (1) is any one of N,N-dimethylformamide, isopropanol, methanol, diethyl ether or ethyl acetate, or a combination of at least two thereof; Preferably, the reaction in step (1) is carried out under nitrogen protection.

6. The preparation method according to claim 4 or 5, characterized in that: The siloxane compound in step (2) is methacryloxypropyl tris(trimethylsiloxy)silane, methacryloxypropyl tris(trimethoxy)silane or vinyl trimethoxysilane; Preferably, the molar ratio of the 2-methacryloyloxyethyl phosphorylcholine to the siloxane compound in step (2) is 1:1-8:1; Preferably, the molar ratio of the siloxane-modified modified phosphorylcholine polymer in step (2) to the developing monomer of formula II is 2:1-8:

1.

7. The preparation method according to any one of claims 4 to 6, characterized in that: The reaction in step (2) is carried out in the presence of 4-cyano-4-(thiobenzoyl)pentanoic acid; Preferably, the molar ratio of 2-methacryloyloxyethyl phosphorylcholine to 4-cyano-4-(thiobenzoyl)pentanoic acid in step (2) is 1:1-5:1; Preferably, the reaction in step (2) is carried out in the presence of an initiator; Preferably, the initiator is selected from azobisisobutyronitrile; Preferably, the molar ratio of the 2-methacryloyloxyethyl phosphorylcholine to the initiator is 1:1-5:1; Preferably, the reaction temperature in step (2) is 60°C-70°C, and the reaction time is 16-64h; Preferably, after the reaction in step (2) is completed, a post-treatment step is further included, wherein the post-treatment step is to precipitate the obtained reaction solution in ether, filter and dry.

8. Use of the novel antifouling developing coating material according to claim 1 or 2 in coating a substrate surface; Preferably, the substrate surface includes a silicon-based surface, a glass-based surface, a metal-based surface, or a high-molecular polymer-based surface.

9. An antifouling developing coating, characterized in that: The raw material for preparing the anti-fouling developing coating comprises the anti-fouling developing coating material as claimed in claim 1 or 2.

10. Use of the antifouling developing coating material according to claim 1 or 2 in medical devices or medical materials, optical lenses or industrial printing.

Images