Natural peach resin essence capable of relieving skin sensitivity, relieving itching and balancing micro-ecological flora, preparation method and application

Abstract

The invention discloses a micro-ecological flora balanced natural peach resin essence capable of relieving skin sensitivity and relieving itching and a preparation method and application thereof.The peach resin essence is prepared from, by weight, 15%-25% of peach resin extract, 10%-20% of white perilla leaf extract, 1.0%-10.0% of bio-saccharide gum-1, 1.0%-1.5% of ethylhexylglycerin and the balance pure water. The components in the essence cooperate with each other to promote the deep absorption of water-soluble active matters to the skin, effectively regulate the steady state of skin micro-ecological flora, quickly relieve skin itch, relieve skin sensitivity, effectively improve dry, desquamation and roughness of the skin, restore skin elasticity and make the skin tender and smooth. The disposable hygienic product prepared from the essence can keep micro-ecological flora balance and reduce skin discomfort. The wash supplies prepared from the essence are externally smeared on the skin, the skin microecological flora steady state can be adjusted, and the skin is protected against environmental stimulation.

Description

Technical Field

[0001] The invention relates to a disposable sanitary product, in particular to an essence liquid for the disposable sanitary product, a preparation method and application thereof. Background Art

[0002] Antibacterial (or antibacterial) liquid products, wet wipes, sanitary napkins, panty liners, sanitary pants and other disposable sanitary products for women are close to the vulva skin. The female vulva is in a humid and stuffy environment for a long time, which can cause redness, swelling, pain, itching and discomfort. In addition, long-term contact with chemical substances can easily cause irritation and allergies. When the number of bacteria is too large, it can easily induce inflammation and discomfort. These problems seriously affect women's quality of life. Summary of the invention

[0003] In order to overcome the deficiencies of the prior art, the present invention provides an ecological flora balanced natural peach resin essence liquid which can relieve skin itching, soothe skin sensitivity and make the skin soft and smooth, as well as a preparation method and use thereof.

[0004] The technical solution adopted by the present invention to solve its technical problem is: The invention discloses a natural peach resin essence liquid which can soothe sensitive skin, relieve itching, and balance microecological flora. The essence liquid is prepared from the following raw materials in percentage by weight: 15-25% of peach resin extract, 10-20% of perilla leaf extract, 1.0-10.0% of biosaccharide gum-1, 1.0-1.5% of ethylhexylglycerin, and the remainder is pure water.

[0005] The preparation method of the above-mentioned microecological flora balanced natural peach resin essence is: add the above-mentioned pure water, peach resin extract, perilla leaf extract, biosaccharide gum-1, and ethylhexylglycerin in the above-mentioned weight parts into a blender, stir and mix at a speed of 50-60 rpm for 15-20 minutes to obtain the peach resin essence.

[0006] A disposable sanitary product comprises the above-mentioned microecological flora balancing peach resin essence.

[0007] A peach resin essence fiber layer for disposable sanitary products, the preparation method of which is: applying the microecological flora balanced peach resin essence onto a viscose fiber layer, drying and forming, and then slitting, pulling and winding to obtain the peach resin essence fiber layer for disposable sanitary products.

[0008] A disposable sanitary product comprises the above-mentioned peach resin essence fiber layer. The disposable sanitary product comprises from top to bottom a skin-contacting surface layer, a peach resin essence fiber layer, an absorbent resin layer, a dust-free paper layer, a release paper layer and a PE coating layer.

[0009] A microecological flora balanced washing and skin care product contains the microecological flora balanced peach resin essence as described above.

[0010] The beneficial effects of the present invention are as follows: the components in the essence of the present invention cooperate with each other, especially the peach resin extract promotes the deep absorption of water-soluble active substances by the skin, effectively regulates the homeostasis of the skin microecological flora, quickly relieves skin itching, soothes skin sensitivity, discharges skin toxins, protects the skin from environmental stimulation, rebuilds the microecological barrier, activates aquaporins, and provides long-lasting hydration for skin cells, which can effectively improve dry, desquamating, and rough skin, restore vaginal elasticity, and make the skin soft and smooth. The disposable sanitary products made of the essence can maintain the balance of the microecological flora and reduce skin discomfort. The washing and care products made of the essence are applied externally on the skin, which can regulate the homeostasis of the skin microecological flora, quickly relieve skin itching, soothe skin sensitivity, discharge skin toxins, and protect the skin from environmental stimulation. DETAILED DESCRIPTION

[0011] A microecological flora balanced peach resin essence is prepared from the following raw materials in percentage by weight: 15-25% of peach resin extract, 10-20% of perilla leaf extract, 1.0-10.0% of biosaccharide gum-1, 1.0-1.5% of ethylhexylglycerol, and the remainder is pure water.

[0012] This embodiment provides three reference formulas. Formula 1: 15% peach resin extract (in this embodiment, peach (Prunus Persica) resin extract is selected, brand name: Amber Peach®), 10% perilla leaf extract (in this embodiment, the product name is: ReSILiEMcare CROP®-G), 1.0% biosaccharide gum-1 (in this embodiment, the product name is: Fucogel biopolysaccharide gum-1), 1.0% ethylhexylglycerol, and the rest is pure water. Formula 2: 25% peach resin extract, 20% perilla leaf extract, 6.0% biosaccharide gum-1, 1.5% ethylhexylglycerol, and the rest is pure water. Formula 3: 20% peach resin extract, 15% perilla leaf extract, 10.0% biosaccharide gum-1, 1.2% ethylhexylglycerol, and the rest is pure water.

[0013] The preparation method of the above-mentioned microecological flora balanced natural peach resin essence is: add the above-mentioned pure water, peach resin extract, perilla leaf extract, biosaccharide gum-1, and ethylhexylglycerin in the above-mentioned weight parts into a blender, stir and mix at a speed of 50-60 rpm for 15-20 minutes to obtain the peach resin essence.

[0014] The microecological flora balance peach resin essence of the present invention can be applied to a disposable sanitary product, such as sanitary napkins, panty liners, sanitary pants, tampons, etc., and can also be applied to toiletries, such as essence, wet wipes base liquid, antibacterial lotion, antibacterial gel, etc. The toiletries made of the essence are applied externally on the skin to maintain the balance of the microecological flora and reduce skin discomfort. The toiletries made of the essence are applied externally on the skin to regulate the homeostasis of the skin microecological flora, quickly relieve skin itching, soothe skin sensitivity, discharge skin toxins, and protect the skin from environmental stimulation.

[0015] When used for disposable sanitary products, a peach resin essence fiber layer needs to be prepared in advance. The preparation method of the peach resin essence fiber layer is: the above-mentioned microecological flora balanced peach resin essence is applied to the viscose fiber layer and dried to form, and then cut, pulled and rolled to obtain the peach resin essence fiber layer for disposable sanitary products.

[0016] The disposable sanitary product using the peach resin essence fiber layer comprises, from top to bottom, a skin-contacting surface layer, a peach resin essence fiber layer, an absorbent resin layer, a dust-free paper layer, a release paper layer and a PE coating layer. Except for the peach resin essence fiber layer, the rest of the structure is the same as that of the current disposable sanitary products.

[0017] The main components of peach resin extract are natural macromolecular polysaccharides such as L-rhamnose, L-arabinose, D-galactose, D-xylose, D-glucuronic acid, and D-mannose, with an average molecular weight of 70-90wDa. When placed under relative humidity of 43%, 60%, and 81% for 48 hours, the moisture absorption rate of peach resin extract is higher than or similar to that of sodium alginate and lower than that of glycerol. However, in a dry environment, the moisture retention rate of peach resin extract is about 18%, which is higher than that of sodium alginate and glycerol.

[0018] Can effectively improve dry, flaky and rough skin Experiment: Instrument: VisioScan VC98 image analyzer.

[0019] Test method: Volunteers: 15 cases, aged 18-60, with dry skin.

[0020] Test sample: 5% peach resin extract.

[0021] Test method: Apply the test sample to a specific area on the outside of the volunteer's calf, and collect the activity status of the skin surface of the test area before, 1h, 2h, and 4h after application.

[0022] Test results: After applying the formula matrix area, the dryness of the skin was temporarily relieved due to moisture replenishment 1 hour later, the scales disappeared, and the roughness decreased. However, after 2 hours and 4 hours, the skin gradually began to flake due to the evaporation of moisture in the formula matrix. After applying 5% peach resin extract area, the scales disappeared and the roughness decreased 1 hour later, and the skin remained plump and smooth after 2 hours and 4 hours.

[0023] Improvement of dry and flaky skin experiment: The skin activity state images collected by VisioScan VC98 image analyzer are digitized to obtain the skin scale index SEsc. The skin scale index SEsc can be used to reflect the degree of exfoliation of the skin stratum corneum. The smaller the value, the less exfoliation of the skin stratum corneum and the less scales. Experiments show that P < 0.01 can effectively smooth the skin scales caused by dryness.

[0024] Experiment on reducing skin roughness: The skin activity state images collected by VisioScan VC98 image analyzer were digitized to obtain the average skin roughness R3. The average skin roughness R3 can be used to characterize the overall roughness of the test area. The larger the value, the rougher the skin. The experiment showed that P < 0.05 can significantly reduce the roughness of dry skin.

[0025] Biosaccharide Gum-1 has a strong water-binding ability and can absorb water well even in a low-humidity environment. It also forms a breathable sugar film on the surface of the skin to prevent the evaporation of skin moisture. Biosaccharide Gum-1 has both immediate and long-lasting hydrating and moisturizing effects.

[0026] The main components of Perilla leaf extract are rosmarinic acid, polysaccharides, glycoproteins, and salvianolic acid. Keratinocyte inflammation experiment: The ratio of phosphorylated JNK protein (pJNK) to the total amount of JNK protein after stimulating human keratinocytes (HaCaT) with culture medium derived from human monocyte culture activated by bacterial LPS for 30, 60 and 90 minutes was measured by ELISA kit. The experimental results showed that JNK was highly activated after 60 minutes of stimulation with LPS-stimulated monocyte culture medium, which could inhibit the degradation of IkB-a and reduce the levels of proinflammatory cytokines: TNF-a and IL-1B.

[0027] Experiment on anti-inflammatory effect on keratinocytes: Acute dermatitis was simulated by treating human keratinocytes with different concentrations of perilla leaf extract active ingredients for 24 hours and stimulating human keratinocytes with culture medium of human monocytes (THP-1) activated by bacterial lipopolysaccharide (LPS). TNF-α, IL-1β and IL-6 cytokines were detected by ELISA kits. The experimental results showed that the perilla leaf extract active ingredients at 100μg / ml could significantly inhibit the release of inflammatory cytokines and almost completely eliminate the excessive release of TNF-α, IL-1β and IL-6.

[0028] Keratinocyte Leukocyte Infiltration Assay: Keratinocytes were grown on a monolayer slide. The cells were treated with 100µg / ml of Perilla leaf extract active substances and then treated with bacterial LPS for 24 hours. THP1 cells (monocytes) were then co-cultured. After washing, the slides were stained with hematoxylin and eosin. Human keratinocytes stimulated with LPS and co-incubated with monocytes exhibited several leukocyte infiltration areas, and the experimental results showed that Perilla leaf extract active substances protected the integrity of the human keratinocyte monolayer from inflammatory damage. The leukocyte infiltration area was significantly reduced.

[0029] Experiment to counteract the effects of LPS and H2O2 by reducing the level of filaggrin: HCaT cells were pretreated with the active ingredients of Perilla frutescens leaves extract for 2 hours and stimulated with LPS (250 ng / mL) and H2O2 (2 mM). The optical density quantification of the level of filaggrin in HCaT cells was obtained by Western blotting, and the experimental results showed that p<0.05.

[0030] Skin barrier repair experiment: 20 female subjects aged 25-65 with normal skin were treated with 2% SLS aqueous solution and Curatest FIL-6 patch was applied to the forearm for 24 hours. Then, 3% Perilla leaf extract was applied to one part of the forearm and placebo was applied to the other part. The transepidermal water loss (TEWL) was measured in g / m2h by VapoMeterDelfin under humidity and temperature controlled conditions (24±2°C; 50±10%RH). After the patch was completed (T1), 3% Perilla leaf extract was applied twice a day for 24 hours and 48 hours after the patch was completed, and the transepidermal water loss TEWL was measured. The product significantly reduced TEWL 24 hours and 48 hours after the patch, by 45% and 66% respectively. The experimental results showed that the TEWL of the Perilla leaf extract site was significantly reduced by 18% compared with the site where the placebo was used.

[0031] Product effect experiment: 30 women aged 40-70 years old, who all had vaginal dryness, irritation and / or loss of firmness, were recruited and divided into 2 groups, 15 in each group, one of which was randomly used with disposable sanitary napkins of Formula 1, Formula 2 or Formula 3 of the present invention, and the other group was used with a placebo. After 2 weeks of use, the deep moisturizing value of the experimental group increased significantly, while there was no significant change in the placebo group. The total elasticity value of the experimental group increased by 6.1% compared with the placebo group, and the total ductility decreased by 17.5%. Genital redness and dryness of the experimental group were significantly reduced.

[0032] The components in the essence of the present invention cooperate with each other, especially the peach resin extract promotes deep absorption of water-soluble active substances by the skin, effectively regulates the homeostasis of the skin microecological flora, quickly relieves skin itching, soothes skin sensitivity, discharges skin toxins, protects the skin from environmental stimulation, rebuilds the microecological barrier, activates aquaporins, and provides long-lasting hydration for skin cells, which can effectively improve dry, desquamating, and rough skin, restore vaginal elasticity, and make the skin soft and smooth. The disposable sanitary products made of the essence can maintain the balance of the microecological flora and reduce skin discomfort. The washing and care products made of the essence are applied externally on the skin, which can regulate the homeostasis of the skin microecological flora, quickly relieve skin itching, soothe skin sensitivity, discharge skin toxins, and protect the skin from environmental stimulation.

[0033] The above implementation modes cannot limit the protection scope of the present invention. The equivalent modifications and changes made by those skilled in the art without departing from the overall concept of the present invention are still within the scope of the present invention.

Claims

1. A microecological flora balanced natural peach resin essence, characterized in that The invention is prepared from the following raw materials in percentage by weight: 15-25% of peach resin extract, 10-20% of white osmanthus leaf extract, 1.0-10.0% of biosaccharide gum-1, 1.0-1.5% of ethylhexylglycerol, and the rest of pure water.

2. The microecological flora balanced natural peach resin essence according to claim 1, characterized in that The invention is prepared from the following raw materials in percentage by weight: 15% peach resin extract, 10% perilla leaf extract, 1.0% biosaccharide gum-1, 1.0% ethylhexylglycerin, and the rest is pure water.

3. The microecological flora balanced natural peach resin essence according to claim 1, characterized in that The invention is prepared from the following raw materials in percentage by weight: 25% of peach resin extract, 20% of white osmanthus leaf extract, 6.0% of biosaccharide gum-1, 1.5% of ethylhexylglycerin, and the rest of pure water.

4. The microecological flora balanced natural peach resin essence according to claim 1, characterized in that The invention is prepared from the following raw materials in percentage by weight: 20% of peach resin extract, 15% of white osmanthus leaf extract, 10.0% of biosaccharide gum-1, 1.2% of ethylhexylglycerin, and the rest of pure water.

5. A method for preparing the microecological flora balanced natural peach resin essence as claimed in any one of claims 1 to 4, characterized in that Add the above-mentioned pure water, peach resin extract, perilla leaf extract, biosaccharide gum-1 and ethylhexylglycerin in parts by weight into a blender, and stir and mix at a speed of 50-60 rpm for 15-20 minutes to obtain peach resin essence.

6. A disposable sanitary product, characterized in that The invention comprises the natural peach resin essence as claimed in any one of claims 1 to 4.

7. A natural peach resin essence fiber layer for disposable sanitary products, characterized in that The preparation method is as follows: the natural peach resin essence liquid described in any one of claims 1 to 4 is applied to a viscose fiber layer for drying and forming, and then the fiber layer of the natural peach resin essence liquid for disposable sanitary products is obtained by slitting, pulling and rolling.

8. A disposable sanitary product, characterized in that The disposable sanitary product comprises the natural peach resin essence fiber layer as claimed in claim 7, and comprises from top to bottom a skin-contacting surface layer, a natural peach resin essence fiber layer, an absorbent resin layer, a dust-free paper layer, a release paper layer and a PE coating layer.

9. A microecological flora balanced toiletries, characterized in that The invention comprises the natural peach resin essence as claimed in any one of claims 1 to 4.