Double-shaft stirring mixer for pharmaceutical-grade liquid medicine

Abstract

The invention discloses a double-shaft stirring mixer for medicine-grade liquid medicine, and relates to the technical field of medicine production. According to the invention, the two swingable mixing stirring shafts are combined with the ultrasonic generators embedded in the stirring blades, so that the mixing effect is enhanced in macroscopic and microcosmic aspects. Due to the swinging design of the stirring shaft, the stirring blades can be in contact with more liquid, and the stirring uniformity is improved. The cavitation effect of ultrasonic waves further promotes refining and dispersion of particles in the liquid, efficient mixing of the medicine is ensured, and the device is particularly suitable for pharmaceutical-grade liquid medicine with high requirements for uniformity; the discharging process is controlled through the electric cylinder, and after mixing is completed, the sealing plug is automatically pulled away, so that mixed liquid is rapidly discharged through the funnel, and residues are prevented from blocking a pipeline. By means of the design, the discharging efficiency is improved, cleanliness of a discharging pipeline is guaranteed, the problems of shutdown and difficult cleaning caused by pipeline blockage in traditional equipment are solved, and the discharging device is particularly suitable for medicine factories with efficient production requirements.

Description

Technical Field

[0001] The invention relates to the technical field of medicine production, in particular to a double-shaft stirring mixer for pharmaceutical-grade liquid medicine. Background Art

[0002] Most of the common pharmaceutical-grade liquid drug stirring equipment on the market currently adopts a single-axis stirring structure. The fixed position and rotation speed of the stirring blade cannot be flexibly adjusted, which easily leads to uneven mixing of the drug liquid. In addition, traditional stirring equipment generally lacks an efficient discharge system, and the liquid remains inside the equipment, resulting in incomplete discharge, increasing waste and cleaning difficulty in the production process. Especially in the cleaning process, traditional equipment usually requires manual disassembly and flushing, which is inefficient and prone to the risk of cross contamination. Therefore, the existing technology has significant deficiencies in stirring uniformity, discharge efficiency and equipment cleaning. Summary of the invention

[0003] In order to overcome the defects of the above-mentioned prior art, the present invention provides the following technical solutions: a double-shaft stirring mixer for pharmaceutical-grade liquid drugs, comprising a base barrel, a mixing bottom sealing plate is fixed on the top of the base barrel, a plurality of discharge ports are opened at the circumference of the mixing bottom sealing plate, a mixing and stirring chamber is fixedly provided on the mixing bottom sealing plate, the mixing and stirring chamber is used to accommodate the drug liquid to be mixed, and the discharge port is used to discharge the mixed drug liquid, wherein each discharge port is sealed with a blocking sealing plug, all the blocking sealing plugs are fixed on a funnel, and the funnel is used to drain all the discharged drug liquid into a discharge pipe; two mixing and stirring shafts are also rotatably installed inside the mixing and stirring chamber, each mixing and stirring shaft is fixed with a plurality of stirring blades, and each mixing and stirring shaft can swing relative to each other to change the stirring position of the stirring blade inside the mixing and stirring chamber, and an ultrasonic generator is embedded inside each stirring blade.

[0004] Preferably, the funnel and all the plugging seals are in sliding and sealing cooperation with the inner wall of the base barrel, and a discharge intermediate tube is fixed at the bottom of the funnel, and the discharge intermediate tube is in sliding and sealing cooperation with the discharge tube.

[0005] Preferably, two concentrically arranged center dial plates and edge dial plates are rotatably matched on the upper surface of the mixing bottom sealing plate, and two concentrically arranged active rotating magnetic disks and an intermediate driving gear plate are rotatably matched on the lower surface of the mixing bottom sealing plate, wherein the intermediate driving gear plate and the center dial plate are fixedly and synchronously driven via a synchronous transmission shaft, the synchronous transmission shaft and the mixing bottom sealing plate are rotationally sealed, and the edge dial plate and the active rotating magnetic disk are transmission matched by magnetic coupling.

[0006] Preferably, the two mixing and stirring shafts are arranged along the axial direction of the mixing and stirring chamber, and two symmetrically arranged driven mixing gears are rotatably installed on the lower surface of the mixing bottom sealing plate. The two driven mixing gears are meshed with the intermediate driving gear plate for transmission, and two universal joints are rotatably installed on the upper surface of the mixing bottom sealing plate. The two universal joints and the two driven mixing gears are fixedly coupled with the rotating shafts, and the two mixing and stirring shafts are coupled with the two driven mixing gears through corresponding universal joints.

[0007] Preferably, the active rotating disk and the synchronous transmission shaft are fixedly matched through a rotating disk bracket, and a spline shaft is fixed to the bottom end of the synchronous transmission shaft. A cleaning brush hollow frame is sleeved on the spline shaft in a spline sliding manner, and a plurality of cleaning brushes that slide and rotate with the inner wall of the funnel are fixed on the cleaning brush hollow frame, wherein the cleaning brush hollow frame is rotationally matched with the discharge intermediate tube, and a plurality of through holes are opened on the cleaning brush hollow frame for discharging the drug liquid, and the cleaning brush hollow frame and the discharge intermediate tube cannot be axially displaced.

[0008] Preferably, two symmetrically arranged electric cylinders are fixedly mounted on the inner wall of the base barrel via electric cylinder brackets, and the ends of the telescopic rods of the two electric cylinders are fixedly matched with the funnel.

[0009] Preferably, a top adjustment support plate is fixed at the top of the mixing chamber, an annular electromagnet is fixed at the circumference of the upper surface of the top adjustment support plate, a top sealing cover plate is fixed on the annular electromagnet, an adjustment support ring is fixed between the top sealing cover plate and the top adjustment support plate, and two symmetrically arranged adjustment support frames are slidably installed on the adjustment support ring through two corresponding parallel adjustment support slide rods, and the two adjustment support frames are rotatably matched with an adjustment movable slider at one end close to the mixing shaft, and the adjustment movable slider is slidably sleeved on the corresponding mixing shaft.

[0010] Preferably, each adjustment support slide rod is surrounded by a reset spring, and both ends of the reset spring are fixed to the adjustment support frame and the adjustment support ring. A permanent magnet block is fixed to the end of the adjustment support slide rod away from the adjustment support frame, and the permanent magnet block cooperates with the magnetic force of the annular electromagnet.

[0011] Preferably, an overhead cover is fixedly mounted on the top sealing cover plate, a driving motor is fixedly mounted on the overhead cover, a plurality of feed ports are also provided on the overhead cover, and the output shaft of the driving motor and the center dial wheel are fixedly driven via a main shaft.

[0012] Compared with the prior art, the present invention has the following beneficial effects: (1) The present invention enhances the mixing effect at both the macroscopic and microscopic levels by combining two swingable mixing and stirring shafts with an ultrasonic generator embedded in the stirring blades. The swinging design of the stirring shaft enables the stirring blades to contact more liquids, thereby maximizing the mixing uniformity. The cavitation effect of the ultrasonic wave further promotes the particle refinement and dispersion inside the liquid, ensuring the efficient mixing of the medicine, and is particularly suitable for pharmaceutical-grade liquid medicines with high requirements for uniformity; (2) The multiple discharge ports in the present invention are equipped with sealing plugs, and the discharge process is controlled by an electric cylinder. When the mixing is completed, the sealing plug is automatically withdrawn, so that the mixed liquid is quickly discharged through the funnel to avoid residues clogging the pipeline. This design not only improves the discharge efficiency, but also ensures the cleanliness of the discharge pipeline, avoiding the shutdown and cleaning difficulties caused by pipeline blockage in traditional equipment, and is particularly suitable for pharmaceutical factories with high production requirements; (3) The cleaning brush hollow frame equipped in the present invention can automatically clean the inner wall of the funnel when the synchronous transmission shaft rotates, reducing the manual cleaning process after the equipment is running. This not only improves the cleaning efficiency, but also reduces the risk of cross contamination. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] Figure 1 This is the overall external structure diagram of the present invention.

[0014] Figure 2 It is a structural schematic diagram of the electric cylinder of the present invention.

[0015] Figure 3 For the present invention Figure 2 Schematic diagram of the structure at point A in the middle.

[0016] Figure 4 It is a schematic diagram of the internal structure of the mixing and stirring chamber of the present invention.

[0017] Figure 5 It is a schematic diagram of the funnel structure of the present invention.

[0018] Figure 6 It is a structural schematic diagram of the center dial plate of the present invention.

[0019] In the figure: 101-base barrel; 102-discharge pipe; 103-electric cylinder bracket; 104-discharge middle pipe; 105-electric cylinder; 106-funnel; 107-spline shaft; 108-synchronous transmission shaft; 109-cleaning brush; 110-cleaning brush hollow frame; 111-blocking sealing plug; 112-discharge port; 113-active rotating disk; 114-rotating disk bracket; 115-mixing bottom sealing plate; 116-middle driving gear disk; 117-driven mixing gear; 118-mixing stirring Shaft; 119-stirring blade; 120-universal joint; 121-center dial; 122-edge dial; 123-mixing and stirring chamber; 124-top adjustment support plate; 125-adjustment support ring; 126-adjustment support slide bar; 127-adjustment support frame; 128-adjustment movable slide block; 129-reset spring; 130-permanent magnet block; 131-top sealing cover plate; 132-ring electromagnet; 133-overhead cover; 134-drive motor; 135-feed port; 136-spindle. DETAILED DESCRIPTION

[0020] The following is combined with Figure 1-6 , and further illustrate the technical solution of the present invention through specific implementation methods.

[0021] The present invention provides a dual-shaft stirring mixer for pharmaceutical-grade liquid drugs, comprising a base barrel 101, a mixing bottom sealing plate 115 is fixed on the top of the base barrel 101, a plurality of discharge ports 112 are opened at the circumference of the mixing bottom sealing plate 115, a mixing and stirring chamber 123 is fixedly arranged on the mixing bottom sealing plate 115, the mixing and stirring chamber 123 is used to contain the drug liquid to be mixed, and the discharge ports 112 are used to discharge the mixed drug liquid, wherein each discharge port 112 is sealed and plugged with a blocking seal plug 112. 1. All the plugging and sealing plugs 111 are fixed on the funnel 106, and the funnel 106 is used to drain all the discharged pharmaceutical liquid into the discharge pipe 102; two mixing and stirring shafts 118 are also rotatably installed inside the mixing and stirring chamber 123, and each mixing and stirring shaft 118 is fixed with multiple stirring blades 119, and each mixing and stirring shaft 118 can swing with each other to change the stirring position of the stirring blades 119 inside the mixing and stirring chamber 123, and each stirring blade 119 is embedded with an ultrasonic generator. The funnel 106 and all the plugging and sealing plugs 111 are slidably sealed with the inner wall of the base barrel 101, and the discharge intermediate pipe 104 is fixed at the bottom of the funnel 106, and the discharge intermediate pipe 104 and the discharge pipe 102 are slidably sealed.

[0022] Two concentrically arranged center dial plates 121 and edge dial plates 122 are rotatably matched on the upper surface of the mixing bottom sealing plate 115, and two concentrically arranged active rotating magnetic disks 113 and an intermediate driving gear plate 116 are rotatably matched on the lower surface of the mixing bottom sealing plate 115, wherein the intermediate driving gear plate 116 and the center dial plate 121 are fixedly synchronously driven via a synchronous transmission shaft 108, the synchronous transmission shaft 108 and the mixing bottom sealing plate 115 are rotationally sealed, wherein the edge dial plate 122 and the active rotating magnetic disk 113 are transmission matched by magnetic coupling. Two mixing and stirring shafts 118 are arranged along the axial direction of the mixing and stirring chamber 123, and two symmetrically arranged driven mixing gears 117 are rotatably installed on the lower surface of the mixing bottom sealing plate 115. The two driven mixing gears 117 are meshed with the intermediate driving gear plate 116 for transmission. Two universal joints 120 are rotatably installed on the upper surface of the mixing bottom sealing plate 115. The two universal joints 120 and the two driven mixing gears 117 are fixedly coupled with the rotating shafts, and the two mixing and stirring shafts 118 and the two driven mixing gears 117 are coupled with each other through corresponding universal joints 120 for transmission. The active rotating disk 113 and the synchronous transmission shaft 108 are fixedly matched through the rotating disk bracket 114. The bottom end of the synchronous transmission shaft 108 is fixed with a spline shaft 107. The spline shaft 107 is sleeved with a cleaning brush hollow frame 110 in a spline sliding manner. The cleaning brush hollow frame 110 is fixed with multiple cleaning brushes 109 that slide and rotate with the inner wall of the funnel 106. The cleaning brush hollow frame 110 rotates with the discharge intermediate tube 104. The cleaning brush hollow frame 110 is provided with multiple through holes for discharging the drug liquid. The cleaning brush hollow frame 110 and the discharge intermediate tube 104 cannot be axially displaced. Two symmetrically arranged electric cylinders 105 are fixedly installed on the inner wall of the base barrel 101 through the electric cylinder bracket 103. The ends of the telescopic rods of the two electric cylinders 105 are fixedly matched with the funnel 106.

[0023] A top adjustment support plate 124 is fixed to the top of the mixing and stirring chamber 123, and an annular electromagnet 132 is fixed to the circumference of the upper surface of the top adjustment support plate 124. A top sealing cover plate 131 is fixed to the annular electromagnet 132, and an adjustment support ring 125 is fixed between the top sealing cover plate 131 and the top adjustment support plate 124. Two symmetrically arranged adjustment support frames 127 are slidably installed on the adjustment support ring 125 through two corresponding parallel adjustment support slide bars 126. The ends of the two adjustment support frames 127 close to the mixing and stirring shaft 118 are both rotatably matched with an adjustment movable slide block 128, and the adjustment movable slide block 128 is slidably sleeved on the corresponding mixing and stirring shaft 118. A return spring 129 is sleeved around each adjustment support slide bar 126, and the two ends of the return spring 129 are fixed to the adjustment support frame 127 and the adjustment support ring 125. A permanent magnet block 130 is fixed to the end of the adjustment support slide bar 126 away from the adjustment support frame 127, and the permanent magnet block 130 is magnetically matched with the annular electromagnet 132. An overhead cover 133 is fixedly mounted on the top sealing cover plate 131 , a driving motor 134 is fixedly mounted on the overhead cover 133 , a plurality of feed ports 135 are also provided on the overhead cover 133 , and a main shaft 136 is used for fixed transmission between the output shaft of the driving motor 134 and the center dial wheel 121 .

[0024] The working principle of a dual-axis stirring mixer for pharmaceutical-grade liquid drugs disclosed in the present invention is as follows: the drugs to be mixed are poured into the mixing and stirring chamber 123 through the feed port 135, and then the drive motor 134 is started. The output shaft of the drive motor 134 drives the center dial 121 to rotate through the main shaft 136. The rotation of the center dial 121 will drive the intermediate drive gear plate 116 and the rotating disk bracket 114 to rotate through the synchronous transmission shaft 108, wherein the rotating disk bracket 114 will drive the active rotating disk 113 to rotate, and the active rotating disk 113 drives the edge dial 122 to rotate through magnetic force. At this time, the rotation of the center dial 121 and the edge dial 122 will drive the drug liquid inside the mixing and stirring chamber 123 to rotate. At the same time, the rotation of the intermediate driving gear disk 116 will drive the two driven mixing gears 117 to rotate. The two driven mixing gears 117 will drive the mixing stirring shaft 118 to rotate through the universal joint 120. The mixing stirring shaft 118 will drive the stirring blades 119 to rotate. The rotation of the stirring blades 119 will drive the surrounding drug liquid to rotate, and cooperate with the center dial 121 and the edge dial 122 to drive the rotation of the drug liquid, thereby achieving the mixing of all drugs inside the mixing stirring chamber 123. At the same time, in order to better allow the stirring blade 119 to contact with more drug liquid, the mixing and stirring shaft 118 can be driven to swing, so that the stirring blade 119 swings, thereby making the stirring blade 119 contact with more drug liquid. Specifically, it is only necessary to control the annular electromagnet 132 to generate magnetic force. The annular electromagnet 132 will repel or attract the permanent magnet block 130, thereby driving the permanent magnet block 130 away from or close to the new annular electromagnet 132. The movement of the permanent magnet block 130 will drive the adjustment support slide bar 126 to move, and the adjustment support slide bar 126 will drive the adjustment support frame 127 to move. The adjustment support frame 127 will drive the adjustment movable slider 128 to slide on the mixing and stirring shaft 118. At this time, the top end of the mixing and stirring shaft 118 will swing, thereby changing the position of the stirring blade 119 in the mixing and stirring chamber 123, wherein the reset spring 129 can restore the mixing and stirring shaft 118 to a vertical position when the annular electromagnet 132 loses its magnetic force. While the stirring blade 119 is stirring the drug liquid, the ultrasonic generator inside the stirring blade 119 is started to enhance the mixing at the microscopic level through the ultrasonic cavitation effect.

[0025] After the mixing is completed, the electric cylinder 105 is started, and the telescopic rod of the electric cylinder 105 drives the funnel 106 to slide downward on the inner wall of the base barrel 101, so that the blocking sealing plug 111 is pulled out from the discharge port 112. At this time, the discharge port 112 is in an open state, and the liquid inside the mixing chamber 123 will enter the funnel 106 through the discharge port 112, and then be discharged into the discharge pipe 102 through the discharge intermediate pipe 104. The mixed drug liquid is discharged to a designated location for collection and treatment through the discharge pipe 102. If the entire equipment needs to be cleaned, it is only necessary to replace the drug with water (select a suitable cleaning liquid according to actual conditions). When the synchronous transmission shaft 108 rotates, the cleaning brush hollow frame 110 will be driven to rotate through the spline shaft 107, and the cleaning brush hollow frame 110 will drive the cleaning brush 109 to rotate. When the cleaning brush 109 rotates, it will clean the residual liquid on the inner wall of the funnel 106.

Claims

1. A dual-shaft stirring mixer for pharmaceutical-grade liquid drugs, characterized in that: The invention comprises a base barrel (101), a mixing bottom sealing plate (115) is fixed on the top of the base barrel (101), a plurality of discharge ports (112) are provided at the circumference of the mixing bottom sealing plate (115), a mixing and stirring chamber (123) is fixedly provided on the mixing bottom sealing plate (115), the mixing and stirring chamber (123) is used to contain the pharmaceutical liquid to be mixed, the discharge ports (112) are used to discharge the mixed pharmaceutical liquid, wherein a blocking sealing plug (111) is sealed and inserted in each discharge port (112), all the blocking sealing plugs (111) are fixed on the funnel (106), and the funnel (106) is used to drain all the discharged pharmaceutical liquid into the discharge pipe (102); Two mixing and stirring shafts (118) are rotatably mounted inside the mixing and stirring chamber (123), and a plurality of stirring blades (119) are fixed to each mixing and stirring shaft (118). Each mixing and stirring shaft (118) is capable of swinging relative to each other to change the stirring position of the stirring blades (119) inside the mixing and stirring chamber (123), and an ultrasonic generator is embedded inside each stirring blade (119); Two mixing and stirring shafts (118) are arranged along the axial direction of the mixing and stirring chamber (123); two symmetrically arranged driven mixing gears (117) are rotatably mounted on the lower surface of the mixing bottom sealing plate (115); the two driven mixing gears (117) are meshed with the intermediate driving gear plate (116) for transmission; two universal joints (120) are rotatably mounted on the upper surface of the mixing bottom sealing plate (115); the two universal joints (120) and the two driven mixing gears (117) are fixedly coupled with each other through a rotating shaft for transmission; The mixing and stirring shafts (118) and the two driven mixing gears (117) are matched through corresponding universal joints (120); a return spring (129) is provided around each adjusting support slide bar (126); both ends of the return spring (129) are fixed to the adjusting support frame (127) and the adjusting support ring (125); a permanent magnet block (130) is fixed to one end of the adjusting support slide bar (126) away from the adjusting support frame (127); the permanent magnet block (130) and the annular electromagnet (132) are matched by magnetic force.

2. A dual-shaft stirring mixer for pharmaceutical-grade liquid medicine according to claim 1, characterized in that: The funnel (106) and all the blocking sealing plugs (111) are in sliding sealing cooperation with the inner wall of the base barrel (101); a discharge intermediate tube (104) is fixed at the bottom of the funnel (106); and the discharge intermediate tube (104) is in sliding sealing cooperation with the discharge tube (102).

3. A dual-shaft stirring mixer for pharmaceutical-grade liquid medicine according to claim 2, characterized in that: Two concentrically arranged central dial discs (121) and an edge dial disc (122) are rotatably engaged on the upper surface of the mixing bottom sealing plate (115), and two concentrically arranged active rotating magnetic discs (113) and an intermediate driving toothed disc (116) are rotatably engaged on the lower surface of the mixing bottom sealing plate (115), wherein the intermediate driving toothed disc (116) and the central dial disc (121) are fixedly and synchronously driven via a synchronous transmission shaft (108), the synchronous transmission shaft (108) and the mixing bottom sealing plate (115) are rotationally and sealedly engaged, and the edge dial disc (122) and the active rotating magnetic disc (113) are transmission engaged via magnetic coupling.

4. A dual-shaft stirring mixer for pharmaceutical-grade liquid medicine according to claim 3, characterized in that: The active rotating disk (113) and the synchronous transmission shaft (108) are fixedly coupled via a rotating disk bracket (114); a spline shaft (107) is fixed to the bottom end of the synchronous transmission shaft (108); a cleaning brush hollow frame (110) is sleeved on the spline shaft (107) in a spline sliding manner; a plurality of cleaning brushes (109) that slide and rotate with the inner wall of the funnel (106) are fixed to the cleaning brush hollow frame (110); the cleaning brush hollow frame (110) and the discharge intermediate tube (104) are rotationally coupled; a plurality of through holes are provided on the cleaning brush hollow frame (110) for discharging the drug liquid; and the cleaning brush hollow frame (110) and the discharge intermediate tube (104) cannot be axially displaced.

5. A dual-shaft stirring mixer for pharmaceutical-grade liquid medicine according to claim 4, characterized in that: Two symmetrically arranged electric cylinders (105) are fixedly mounted on the inner wall of the base barrel (101) via an electric cylinder bracket (103), and the ends of the telescopic rods of the two electric cylinders (105) are fixedly matched with the funnel (106).

6. A dual-shaft stirring mixer for pharmaceutical-grade liquid medicine according to claim 5, characterized in that: A top adjustment support plate (124) is fixed to the top of the mixing chamber (123); an annular electromagnet (132) is fixed at the circumference of the upper surface of the top adjustment support plate (124); a top sealing cover plate (131) is fixed to the annular electromagnet (132); an adjustment support ring (125) is fixed between the top sealing cover plate (131) and the top adjustment support plate (124); two symmetrically arranged adjustment support frames (127) are slidably mounted on the adjustment support ring (125) via two corresponding parallelly arranged adjustment support slide bars (126); one end of the two adjustment support frames (127) close to the mixing shaft (118) is rotatably matched with an adjustment movable slide block (128); the adjustment movable slide block (128) is slidably sleeved on the corresponding mixing shaft (118).

7. A dual-shaft stirring mixer for pharmaceutical-grade liquid medicine according to claim 6, characterized in that: An overhead cover (133) is fixedly mounted on the top sealing cover plate (131), a driving motor (134) is fixedly mounted on the overhead cover (133), a plurality of feed ports (135) are also provided on the overhead cover (133), and a main shaft (136) is used for fixed transmission between the output shaft of the driving motor (134) and the center dial wheel (121).

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