High performance liquid chromatograph capable of controlling flow velocity

Abstract

The invention provides a high performance liquid chromatograph capable of controlling flow velocity, the high performance liquid chromatograph comprises an instrument body, four double-tube pump sets are arranged on the upper side in the instrument body, one-way pistons are arranged in the double-tube pump sets in a penetrating manner, the outer surfaces of the one-way pistons slide on the inner walls of the double-tube pump sets in a sealing manner, and the two ends of the one-way pistons are connected with the two ends of the instrument body. A curved bar transmission set is arranged on one side of the double-pipe pump set, a curved bar in the middle of the curved bar transmission set is hinged to the end of the one-way piston, a solution collecting box is arranged on the side, away from the one-way piston, of the curved bar transmission set, one side of the top of the double-pipe pump set communicates with the interior of the solution collecting box in a one-way mode, and a bubble removing frame is slidably connected to the inner side of the solution collecting box. One end of the bubble removing frame slides on the outer side of the solution collecting box, and bidirectional driving parts are arranged at the two ends of the curved bar transmission set; according to the liquid chromatograph, bubbles can be automatically discharged, the manual adjustment process is reduced, and the liquid chromatograph is more convenient and efficient to use.

Description

Technical Field

[0001] The invention relates to the field of high performance liquid chromatographs, in particular to a high performance liquid chromatograph capable of controlling flow rate. Background Art

[0002] High performance liquid chromatography is a commonly used chromatographic analysis technology, widely used in chemistry, biology, medicine, environment and other fields. It uses a high-pressure pump to pass the sample solution through a chromatographic column filled with a stationary phase at a certain flow rate, and uses the different distribution coefficients of each component in the sample between the mobile phase and the stationary phase to achieve component separation.

[0003] During the use of the HPLC, a high-pressure pump is used to draw the stock solution to fill the inside of the device, and then the solution to be tested is drawn through the infusion tube to complete the content detection of various solutions and generate a chromatographic column. However, before the HPLC is used, the air in the stock solution pipeline and the stock solution needs to be discharged. This requires manual operation, which is inconvenient and takes a long time to remove the bubbles, and it cannot be discharged efficiently and automatically.

[0004] Therefore, we made improvements on this and proposed a high performance liquid chromatograph that can control the flow rate. Summary of the invention

[0005] The purpose of the present invention is to solve the problem that the existing bubbles cannot be automatically and efficiently discharged, which is inconvenient to use.

[0006] In order to achieve the above-mentioned object of the invention, the present invention provides the following high performance liquid chromatograph capable of controlling flow rate to improve the above-mentioned problem.

[0007] The specific application is as follows:

[0008] A high performance liquid chromatograph capable of controlling flow rate comprises an instrument body, a double-tube pump group is provided on the upper side of the interior of the instrument body, the double-tube pump group is provided with four groups, a one-way piston is passed through the interior of the double-tube pump group, the outer surface of the one-way piston is sealed and slides on the inner wall of the double-tube pump group, a bent rod transmission group is provided on one side of the double-tube pump group, a bent rod in the middle of the bent rod transmission group is hinged to the end of the one-way piston, a solution collection box is provided on the side of the bent rod transmission group away from the one-way piston, one side of the top of the double-tube pump group is unidirectionally connected to the interior of the solution collection box, a bubble removal rack is slidably connected to the inside of the solution collection box, one end of the bubble removal rack slides on the outside of the solution collection box, two ends of the bent rod transmission group are provided with bidirectional driving parts, and the bidirectional driving part is transmission-connected to the bubble removal rack in the reverse driving state of the bent rod transmission group.

[0009] As a preferred technical solution of the present application, the instrument body includes a solvent bottle holder, a pump group portion is provided on the bottom surface of the solvent bottle holder, a filter portion is provided on the bottom surface of the pump group portion, a sample portion is provided on the bottom surface of the filter portion, a chromatographic column is provided on the bottom surface of the sample portion, a column temperature box is provided on the bottom surface of the chromatographic column, and the double-tube pump group, curved rod transmission group, and solution collection box are located inside the pump group portion.

[0010] As a preferred technical solution of the present application, the double-tube pump group includes a solution cavity, and the solution cavity is provided with four groups. A bottle body connecting tube is connected to the top of the solution cavity, and the end of the bottle body connecting tube facing away from the solution cavity is passed through the inner side of the solvent bottle bracket, and a symmetrical pump tube is connected to one side of the solution cavity, and the one-way piston is passed through the inside of the pump tube, and a sealing block is fixed to the end of the pump tube facing away from the solution cavity, and a first sealing ring arranged equidistantly is provided inside the sealing block, one end of the one-way piston is passed through the inside of the sealing block and slides in contact with the first sealing ring, the top surface of one end of the pump tube connected to the sealing block is connected to an infusion tube, and the other end of the infusion tube is connected to the inside of the solution collection box, and a one-way valve is provided at one end of the infusion tube connected to the pump tube.

[0011] As a preferred technical solution of the present application, the one-way piston includes a piston seal, a double-piece valve, and a rotary driving member. The piston seal is located on the inner side of the pump tube, and the middle part of one end of the piston seal is connected to a piston push-pull rod, and the end of the piston push-pull rod away from the piston seal is arranged on the inner side of the sealing block and slides in engagement with the first sealing ring. The end of the piston push-pull rod facing away from the piston seal is hinged to the crankshaft transmission group, and the piston seal is provided with a through opening at the center of the piston seal, and two symmetrical groups of sealing ring grooves are provided on both sides of the outer wall of the one-way piston, a second sealing ring is provided inside the sealing ring groove, and the outer wall of the second sealing ring is in engagement with the inner surface of the pump tube, the double-piece valve is connected to the middle inner side of the through opening, and a one-way limiting groove is provided at the position where the through opening is connected to the double-piece valve, and two ends of the double-piece valve are in contact with the inner wall of the one-way limiting groove, and the rotary driving member is located on both sides of the outer wall of the piston seal, the outer wall of one side of the rotary driving member is slidably connected to the inner wall of the pump tube, and the two ends of the rotary driving member are transmission connected to the double-piece valve.

[0012] As a preferred technical solution of the present application, the double-piece valve includes a valve stem, both ends of which are fixed on the inner wall of the one-way limit groove, symmetrical valve plates are hinged on both sides of the middle part of the valve stem, the outer ends of the valve plates are in contact with the inner wall of the one-way limit groove, and a hinge rod is provided at the position where the valve plate and the valve stem are hinged, and both ends of the hinge rod are passed through the outer sides of both ends of the valve stem, and driven gears are fixed at both ends of the hinge rod, and the driven gears are meshed with the rotating driving member for transmission.

[0013] As a preferred technical solution of the present application, the rotating driving member includes a roller, which is rotatably connected to the inside of both sides of the piston seal, and the outer surface of the roller is in contact with the inner wall of the pump pipe, and the two ends of the roller located inside the piston seal are connected to driving cone wheels, and the position inside the piston seal connected to the driving cone wheel is rotatably connected to a transmission shaft, and a transmission cone wheel is fixed at one end of the transmission shaft close to the driving cone wheel, and the transmission cone wheel is meshed with the driving cone wheel for transmission, and a transmission gear is fixed to the other end of the transmission shaft, and the transmission gear is meshed with the driven gear for transmission.

[0014] As a preferred technical solution of the present application, the crankshaft transmission group includes a transmission crankshaft, a connecting rod is hinged in the middle of the transmission crankshaft, the end of the connecting rod away from the transmission crankshaft is hinged to the piston push-pull rod, and symmetrical driving shafts are connected at both ends of the transmission crankshaft. The bidirectional driving part is connected to the outside of the driving shaft, one end of the driving shaft is rotatably connected to the inner wall of the pump group, and the other end of the driving shaft is provided with a stepless motor. The output end of the stepless motor is transmission-connected to the driving shaft, and the stepless motor is fixed inside the pump group.

[0015] As a preferred technical solution of the present application, a bubble collecting box is provided on the top surface of the solution collection box, and the bubble collecting box is connected to the top of the inner side of the solution collection box. A grid is provided at the position where the solution collection box is connected to the bubble collection box, and symmetrical sealing grooves are provided on the bottom surface of the grid at both ends of the solution collection box. The bubble removal frame slides inside the sealing grooves, the top surface of the bubble collection box is connected to a bubble drainage pipe, and the bottom surface of the solution collection box is connected to a solution delivery pipe.

[0016] The cam is an assembly made of a plurality of movable parts, each of which is connected to a pair of movable parts in a plurality of movable parts. The movable parts are connected to a pair of movable parts in a plurality of movable parts. The movable parts are connected to a pair of movable parts in a plurality of movable parts.

[0017] As a preferred technical solution of the present application, the bidirectional driving part includes a driving retaining ring, which is fixed on a side of the driving shaft connected to the transmission bent rod, and a reset retaining ring is provided on the side of the driving retaining ring away from the driving shaft, and the outer wall of the driving shaft connected to the driving retaining ring is provided with threaded teeth, and a cam driving member is screwed on the outer side of the threaded teeth in threaded engagement, and a second spring is provided on a side of the reset retaining ring close to the driving retaining ring, and one end of the second spring facing away from the reset retaining ring abuts against the cam driving member, and a driving protrusion is fixed on one side of the outer wall of the cam driving member, and the driving protrusion abuts against the end of the transmission guide rod, and a spring limiting ring is fixed on the side of the cam driving member connected to the second spring, and one end of the second spring connected to the cam driving member is located on the inner side of the spring limiting ring.

[0018] Compared with the prior art, the present invention has the following beneficial effects:

[0019] In the scheme of the present application: by synchronously driving the double one-way pistons through the curved rod transmission group, the function of uninterrupted solution delivery can be achieved, and at the same time, the solution flow rate can be freely controlled through the speed adjustment of the stepless motor. A solution collection box is provided on one side of the double-tube pump group to collect the solution delivered by the double-tube pump group, and the bubbles contained in the solution are separated from the solution through the bubble removal rack, and the bubble removal rack can cooperate with the curved rod transmission group to automatically complete the discharge of bubbles, reduce the process of manual adjustment, and make the use of liquid chromatograph more convenient and efficient.

[0020] 1. The double-tube pump set of the present invention adopts double pump tubes to absorb the solution inside a single solution bottle, and can cooperate with the piston transmission method to allow the solution to be transmitted uninterruptedly. At the same time, the sealing of the transportation is guaranteed during the transportation process, and the forward transportation of the solution can be ensured, thereby achieving high-precision control of the flow rate of the solution, and the sealing block can seal the pump tube transmission.

[0021] 2. The present invention has a one-way piston slidably connected to the inner side of the pump tube, and the solution inside the pump tube can be extracted to the outside through the reciprocating sliding of the piston. A double valve plate and a rotating drive member are provided inside the piston, which can enable the one-way piston to exert one-way pressure on the solution when sliding back and forth, thereby completing the one-way delivery of the solution, so that the one-way piston will not cause the solution to exert pressure on the inside of the solution bottle when sliding in the return stroke.

[0022] 3. During the driving process, the crankshaft transmission group of the present invention can be connected to the one-way piston through the crankshaft and the connecting rod to realize the function of reciprocating and staggered extraction of solution by the double pump tubes inside the single solution bottle, complete the driving of the one-way piston, and thus realize uninterrupted delivery of the solution inside the single solution bottle. By adjusting the rotation speed of the crankshaft transmission group, the flow rate of the pump tube can be controlled with high precision.

[0023] 4. The solution collection box in the present invention can collect and transport the solutions transported by the double-tube pump group together, and the bubbles in the solution can be separated to the inner side of the bubble collection box by the principle of air buoyancy through the bubble collection box, and transported out through the bubble discharge pipe, and the separated pure solution will be transported downward through the solution delivery pipe for use.

[0024] 5. The bubble removal frame in the present invention can cooperate with the grid frame inside the solution collection box to seal the solution collection box and the bubble collection box. When it is necessary to remove bubbles, the bubble collection box can be connected by sliding the bubble removal frame to allow the bubbles inside the solution collection box to be discharged. After the bubbles in the solution are completely discharged, the debubble removal frame is used to complete the sealing of the inside of the solution collection box. The bubble removal frame is driven by the follower assembly and the crankshaft transmission group, and can automatically complete the debubble operation of the bubble removal frame through the drive of the crankshaft transmission group. During the bubble removal process, due to the reciprocating drive of the cam drive member, the high-speed sliding of the bubble removal frame can be achieved, so that the bubbles inside the bubble removal frame can be completely separated from the solution and discharged through the bubble collection box.

[0025] 6. In the present invention, a bidirectional driving part is provided on the outer wall of the driving shaft, which can drive the bubble removal frame through the reverse rotation of the bent rod transmission group to realize the separation and removal of bubbles in the solution. In the process of removing bubbles, the reverse rotation of the bent rod transmission group can still ensure the solution transportation inside the double-tube pump group, and realize the efficient removal of bubbles in the solution. When the bubble removal is completed, the forward-driven stepless motor can transport the solution and disengage from the drive of the bubble removal frame at the same time, completing the normal transportation of the solution. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 A schematic structural diagram of a preferred embodiment of a high performance liquid chromatograph capable of controlling flow rate provided by the present invention;

[0027] Figure 2 for Figure 1 The schematic diagram of the structure of the pump unit shown in FIG.

[0028] Figure 3 for Figure 2 The schematic diagram of the internal structure of the pump unit shown;

[0029] Figure 4 for Figure 3 The structural diagram of the position of the crankshaft transmission group shown;

[0030] Figure 5 for Figure 4 The schematic structural diagram of the double-tube pump unit in cross section shown;

[0031] Figure 6 for Figure 5 A schematic diagram of the structure of the pump tube position shown;

[0032] Figure 7 for Figure 6 The structural sectional exploded schematic diagram of the one-way piston shown;

[0033] Figure 8 for Figure 7 The schematic diagram of the structure of the double-piece valve position shown;

[0034] Fig. 9 for Figure 8 An enlarged schematic diagram of the structure of the position of the rotating drive member shown;

[0035] Fig.10 for Figure 3 A schematic diagram of the structure of the solution collection box position shown;

[0036] Fig.11 for Fig.10 An exploded and enlarged schematic diagram of the structure of the bubble removal rack position is shown;

[0037] Fig.12 for Fig.11 The enlarged schematic diagram of the structure of the driven component and the transmission position of the bidirectional driving part shown;

[0038] Fig.13 for Fig.12 The shown schematic diagram is an enlarged cross-sectional exploded view of the position structure of the driven component and the bidirectional transmission part.

[0039] Indicated in the figure:

[0040] 1. Instrument body; 11. Solvent bottle bracket; 12. Pump unit; 13. Filter unit; 14. Sample unit; 15. Chromatographic column; 16. Column oven;

[0041] 2. Double-tube pump set; 21. Solution chamber; 22. Bottle connecting tube; 23. Pump tube; 24. Sealing block; 25. First sealing ring; 26. Infusion tube; 27. One-way valve;

[0042] 3. One-way piston; 31. Piston seal; 311. Piston push-pull rod; 312. Through port; 313. Sealing ring groove; 314. Second sealing ring; 315. One-way limit groove; 32. Double-plate valve; 321. Valve stem; 322. Valve plate; 323. Hinge rod; 324. Driven gear; 33. Rotary drive member; 331. Roller; 332. Driving cone wheel; 333. Transmission shaft; 334. Transmission cone wheel; 335. Transmission gear;

[0043] 4. crankshaft transmission group; 41. transmission crankshaft; 42. connecting rod; 43. stepless motor; 44. driving shaft;

[0044] 5. Solution collection box; 51. Bubble collection box; 52. Grid; 53. Sealed slide; 54. Bubble drainage pipe; 55. Solution delivery pipe;

[0045] 6. Bubble removal rack; 61. Transmission plate; 62. Driven assembly; 621. Fixed box; 622. Guide rod slide groove; 623. Guide rod limit groove; 624. Transmission guide rod; 625. Limit block; 626. First spring;

[0046] 7. Bidirectional driving part; 71. Driving retaining ring; 72. Reset retaining ring; 73. Threaded teeth; 74. Cam driving member; 741. Driving protrusion; 742. Spring limiting ring; 75. Second spring. DETAILED DESCRIPTION

[0047] In order to enable those skilled in the art to better understand the scheme of the present invention, the technical scheme in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work should fall within the scope of protection of the present invention.

[0048] As described in the background art, the bubbles cannot be automatically and efficiently discharged, which is inconvenient to use.

[0049] In order to solve this technical problem, the present invention provides a high performance liquid chromatograph capable of controlling flow rate, which is applied to automatically discharge bubbles in pipelines before the high performance liquid chromatograph is used, and the bubbles are discharged quickly and efficiently.

[0050] Specifically, please refer to Figure 1-Figure 13 , the high performance liquid chromatograph capable of controlling flow rate specifically comprises:

[0051] An instrument body 1, wherein a double-tube pump group 2 is provided on the upper side of the interior of the instrument body 1, and the double-tube pump group 2 is provided with four groups. A one-way piston 3 is passed through the interior of the double-tube pump group 2, and the outer surface of the one-way piston 3 is sealed and slides on the inner wall of the double-tube pump group 2. A bent rod transmission group 4 is provided on one side of the double-tube pump group 2. The bent rod in the middle of the bent rod transmission group 4 is hinged to the end of the one-way piston 3. A solution collection box 5 is provided on the side of the bent rod transmission group 4 away from the one-way piston 3. One side of the top of the double-tube pump group 2 is unidirectionally connected with the interior of the solution collection box 5. A bubble removal frame 6 is slidably connected to the inside of the solution collection box 5, and one end of the bubble removal frame 6 slides on the outside of the solution collection box 5. Two ends of the bent rod transmission group 4 are provided with bidirectional driving parts 7. When the bent rod transmission group 4 is in the reverse driving state, the bidirectional driving part 7 is transmission-connected to the bubble removal frame 6.

[0052] The present invention provides a high-performance liquid chromatograph that can control the flow rate. By synchronously driving the double one-way pistons 3 through the crankshaft transmission group 4, the function of uninterrupted solution delivery can be realized. At the same time, the speed adjustment of the stepless motor 43 can freely control the solution flow rate. A solution collection box 5 is provided on one side of the double-tube pump group 2 to collect the solution delivered by the double-tube pump group 2, and the bubbles contained in the solution are separated from the solution through the bubble removal rack 6. The bubble removal rack 6 can cooperate with the crankshaft transmission group 4 to automatically complete the discharge of bubbles, reduce the process of manual adjustment, and make the use of the liquid chromatograph more convenient and efficient.

[0053] In order to enable those skilled in the art to better understand the solutions of the present invention, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings.

[0054] It should be noted that, in the absence of conflict, the embodiments of the present invention and the features and technical solutions in the embodiments may be combined with each other.

[0055] It should be noted that similar reference numerals and letters denote similar items in the following drawings, and therefore, once an item is defined in one drawing, further definition and explanation thereof is not required in subsequent drawings.

[0056] Example 1

[0057] Please refer to Figure 1-Figure 13 A high performance liquid chromatograph capable of controlling flow rate, wherein the instrument body 1 comprises a solvent bottle holder 11, a pump group 12 is disposed on the bottom surface of the solvent bottle holder 11, a filter 13 is disposed on the bottom surface of the pump group 12, a sample 14 is disposed on the bottom surface of the filter 13, a chromatographic column 15 is disposed on the bottom surface of the sample group 14, a column temperature box 16 is disposed on the bottom surface of the chromatographic column 15, and the double-tube pump group 2, the crankshaft transmission group 4, and the solution collection box 5 are located inside the pump group 12.

[0058] The double-tube pump group 2 includes a solution chamber 21, and the solution chamber 21 is provided with four groups. A bottle connecting tube 22 is connected to the top of the solution chamber 21. The end of the bottle connecting tube 22 facing away from the solution chamber 21 is passed through the inner side of the solvent bottle bracket 11. A symmetrical pump tube 23 is connected to one side of the solution chamber 21. The one-way piston 3 is passed through the pump tube 23. A sealing block 24 is fixed to the end of the pump tube 23 facing away from the solution chamber 21. The sealing block 24 is provided with first sealing rings 25 arranged equidistantly. One end of the one-way piston 3 is passed through the sealing block 24 and slides in contact with the first sealing ring 25. An infusion tube 26 is connected to the top surface of one end of the pump tube 23 connected to the sealing block 24. The other end of the infusion tube 26 is connected to the inside of the solution collection box 5. A one-way valve 27 is provided at one end of the infusion tube 26 connected to the pump tube 23.

[0059] The double-tube pump group 2 adopts a double pump tube 23 to absorb the solution inside a single solution bottle, and can cooperate with the piston transmission method to allow the solution to be transmitted uninterruptedly. At the same time, the sealing of the transportation is guaranteed during the transportation process, which can ensure the forward transportation of the solution, thereby achieving high-precision control of the flow rate of the solution, and the sealing block 24 can transmit a seal to the pump tube 23.

[0060] Example 2

[0061] The high performance liquid chromatograph capable of controlling flow rate provided in Example 1 is further optimized, specifically, as follows: Figure 1-Figure 13 The one-way piston 3 includes a piston seal 31, a double-piece valve 32, and a rotary drive member 33. The piston seal 31 is located inside the pump tube 23. A piston push-pull rod 311 is connected to the middle of one end of the piston seal 31. The end of the piston push-pull rod 311 away from the piston seal 31 is inserted into the inner side of the sealing block 24 and slides in contact with the first sealing ring 25. The end of the piston push-pull rod 311 away from the piston seal 31 is hinged to the crankshaft transmission group 4. A through hole 312 is opened at the center of the piston seal 31. Two symmetrical sets of seals are opened on both sides of the outer wall of the one-way piston 3. A sealing ring groove 313 is provided with a second sealing ring 314 inside the sealing ring groove 313, and the outer wall of the second sealing ring 314 is fitted on the inner surface of the pump tube 23. The double-piece valve 32 is connected to the middle part of the inner side of the through port 312, and a one-way limiting groove 315 is provided at the position where the through port 312 is connected to the double-piece valve 32, and both ends of the double-piece valve 32 are in contact with the inner wall of the one-way limiting groove 315. The rotary drive member 33 is located on both sides of the outer wall of the piston seal 31, and the outer wall of one side of the rotary drive member 33 is slidably connected to the inner wall of the pump tube 23, and both ends of the rotary drive member 33 are drivingly connected to the double-piece valve 32.

[0062] The double-plate valve 32 includes a valve stem 321, both ends of which are fixed to the inner wall of the one-way limit groove 315, and symmetrical valve plates 322 are hinged on both sides of the middle of the valve stem 321. The outer ends of the valve plates 322 are in contact with the inner wall of the one-way limit groove 315, and a hinge rod 323 is provided at the position where the valve plate 322 and the valve stem 321 are hinged. Both ends of the hinge rod 323 are passed through the outer sides of both ends of the valve stem 321, and driven gears 324 are fixed to both ends of the hinge rod 323, and the driven gear 324 is meshed with the rotating drive member 33 for transmission.

[0063] The rotary drive member 33 includes a roller 331, which is rotatably connected to the inside of both sides of the piston seal 31, and the outer surface of the roller 331 is attached to the inner wall of the pump pipe 23. The two ends of the roller 331 located inside the piston seal 31 are connected to driving cone wheels 332, and the position inside the piston seal 31 connected to the driving cone wheel 332 is rotatably connected to a transmission shaft 333, and a transmission cone wheel 334 is fixed to one end of the transmission shaft 333 close to the driving cone wheel 332, and the transmission cone wheel 334 is meshed with the driving cone wheel 332 for transmission, and a transmission gear 335 is fixed to the other end of the transmission shaft 333, and the transmission gear 335 is meshed with the driven gear 324 for transmission.

[0064] The inner side of the pump tube 23 is slidably connected with a one-way piston 3, and the solution inside the pump tube 23 can be extracted to the outside through the reciprocating sliding of the piston. A double valve plate 322 and a rotating drive member 33 are provided inside the piston, which can enable the one-way piston 3 to exert one-way pressure on the solution when sliding back and forth, thereby completing the one-way delivery of the solution, so that the one-way piston 3 will not exert pressure on the solution inside the solution bottle when sliding back and forth.

[0065] Example 3

[0066] A high performance liquid chromatograph capable of controlling flow rate provided in Example 1 or 2 is further optimized, specifically, as Figure 1-Figure 13 As shown, the crankshaft transmission group 4 includes a transmission crankshaft 41, a connecting rod 42 is hinged in the middle of the transmission crankshaft 41, and one end of the connecting rod 42 away from the transmission crankshaft 41 is hinged to the piston push-pull rod 311, and symmetrical driving shafts 44 are connected to both ends of the transmission crankshaft 41. The bidirectional driving part 7 is connected to the outside of the driving shaft 44, and one end of the driving shaft 44 is rotatably connected to the inner wall of the pump group part 12. The other end of the driving shaft 44 is provided with a stepless motor 43, and the output end of the stepless motor 43 is transmission-connected to the driving shaft 44, and the stepless motor 43 is fixed inside the pump group part 12.

[0067] During the driving process, the curved rod transmission group 4 can be connected to the one-way piston 3 through the curved rod and the connecting rod 42, so as to realize the function of reciprocating and staggered extraction of solution by the double pump tubes 23 inside the single solution bottle, complete the driving of the one-way piston 3, and thus realize uninterrupted delivery of the solution inside the single solution bottle, and by adjusting the rotation speed of the curved rod transmission group 4, the flow rate of the pump tube 23 can be controlled with high precision.

[0068] Example 4

[0069] A high performance liquid chromatograph capable of controlling flow rate provided in Example 1-3 is further optimized, specifically, as Figure 1-Figure 13As shown, a bubble collecting box 51 is provided on the top surface of the solution collecting box 5, and the bubble collecting box 51 is communicated with the top of the inner side of the solution collecting box 5. A grid frame 52 is provided at the position where the solution collecting box 5 is connected to the bubble collecting box 51. Symmetrical sealing grooves 53 are provided on the bottom surface of the grid frame 52 at both ends of the solution collecting box 5. The bubble removal frame 6 slides on the inside of the sealing grooves 53. The top surface of the bubble collecting box 51 is connected to a bubble drainage pipe 54, and the bottom surface of the solution collecting box 5 is connected to a solution delivery pipe 55.

[0070] The solution collection box 5 can collect and transport the solutions transported by the double-tube pump group 2 together, and can separate the bubbles in the solution to the inner side of the bubble collection box 51 through the bubble collection box 51 by utilizing the principle of air buoyancy, and transport them out through the bubble drainage pipe 54, and the separated pure solution will be transported downward for use through the solution delivery pipe 55.

[0071] Example 5

[0072] A high performance liquid chromatograph capable of controlling flow rate provided in Examples 1-4 is further optimized, specifically, Figure 1-Figure 13 As shown, both ends of the bubble removal frame 6 slide inside the sealing slide groove 53, and the middle part of the bubble removal frame 6 slides in contact with the bottom surface of the grid frame 52. Both ends of the bubble removal frame 6 sliding inside the sealing slide groove 53 are connected with a transmission plate 61, and one end of the transmission plate 61 is slidably penetrated outside the solution collection box 5, and one end of the transmission plate 61 located outside the solution collection box 5 is connected with a driven component 62, and the driven component 62 includes a fixed box 621, and the fixed box 621 is fixed to the outer wall of the solution collection box 5, and the one end of the transmission plate 61 located outside the solution collection box 5 is penetrated by the fixed box 6 21, a guide rod slot 622 is provided in the middle of the inner side of the fixed box 621, a guide rod limit slot 623 is provided in the guide rod slot 622 near the transmission plate 61, a transmission guide rod 624 is slidably provided inside the guide rod slot 622, limit blocks 625 are fixed on both sides of the middle of the transmission guide rod 624, the limit blocks 625 slide inside the guide rod limit slot 623, one end of the transmission guide rod 624 is fixedly connected to the transmission plate 61, a first spring 626 is provided inside the guide rod limit slot 623, and one end of the first spring 626 abuts against the outer wall of the limit block 625.

[0073] The bubble removal rack 6 can cooperate with the grid 52 inside the solution collection box 5 to seal the solution collection box 5 and the bubble collection box 51. When it is necessary to remove bubbles, the bubble removal rack 6 can be connected to the bubble collection box 51 by sliding, so that the bubbles inside the solution collection box 5 can be discharged. After the bubbles in the solution are completely discharged, the debubble removal rack is used to complete the sealing of the inside of the solution collection box 5. The bubble removal rack 6 is driven by the follower component 62 and the curved rod transmission group 4, and can automatically complete the debubble operation of the bubble removal rack 6 by the drive of the curved rod transmission group 4. During the bubble removal process, due to the reciprocating drive of the cam driving member 74, the high-speed sliding of the bubble removal rack 6 can be achieved, so that the bubbles inside the bubble removal rack 6 can be completely separated from the solution and discharged through the bubble collection box 51.

[0074] Example 6

[0075] A high performance liquid chromatograph capable of controlling flow rate provided in Examples 1-5 is further optimized, specifically, as Figure 1-Figure 13 As shown, the bidirectional driving portion 7 includes a driving retaining ring 71, which is fixed on the side of the driving shaft 44 connected to the transmission bent rod 41, and a reset retaining ring 72 is provided on the side of the driving retaining ring 71 away from the driving shaft 44. The outer wall of the position where the driving shaft 44 is connected to the driving retaining ring 71 is provided with threaded teeth 73, and the outer side of the threaded teeth 73 is threadedly engaged and screwed with a cam driving member 74. A second spring 75 is provided on the side of the reset retaining ring 72 close to the driving retaining ring 71, and the end of the second spring 75 facing away from the reset retaining ring 72 abuts against the cam driving member 74, and a driving protrusion 741 is fixed on one side of the outer wall of the cam driving member 74, and the driving protrusion 741 abuts against the end of the transmission guide rod 624, and a spring limiting ring 742 is fixed on the side of the cam driving member 74 connected to the second spring 75, and the end of the second spring 75 connected to the cam driving member 74 is located on the inner side of the spring limiting ring 742.

[0076] The outer wall of the driving shaft 44 is provided with a bidirectional driving part 7, which can drive the bubble removal frame 6 through the reverse rotation of the bent rod transmission group 4, so as to separate and remove the bubbles in the solution. In the process of removing bubbles, the reverse rotation of the bent rod transmission group 4 can still ensure the solution transportation inside the double-tube pump group 2, so as to realize the efficient removal of bubbles in the solution. When the bubble removal is completed, the forward-driven stepless motor 43 can transport the solution and disengage from the drive of the bubble removal frame 6 at the same time, so as to complete the normal transportation of the solution.

[0077] Working steps:

[0078] The instrument body 1 is started, and the stepless motor 43 inside the pump group 12 rotates in reverse, driving the drive shaft 44 and the transmission bent rod 41 to rotate. The drive shaft 44 rotates in reverse, and the drive protrusion 741 on the outer wall of the cam drive 74 will be pushed by the second spring 75, so that the drive protrusion 741 abuts against the transmission guide rod 624, forming a blocking thrust. With the push of the second spring 75, the cam drive 74 will engage with the threaded teeth 73 on the outer wall of the drive shaft 44. When the cam drive 74 engages with the threaded teeth 73 until the cam drive 74 abuts against the drive retaining ring 71, the cam drive 74 will be fixed, thereby pushing the transmission guide rod 624 through the drive protrusion 741.

[0079] When the transmission guide rod 624 is pushed, it will slide on the inside of the fixed box 621. When the transmission guide rod 624 slides, it will push the limit block 625 to slide on the inside of the guide rod limit groove 623, applying pressure to the first spring 626. At the same time, the transmission guide rod 624 will push the transmission plate 61, allowing the bubble removal frame 6 connected to the other end of the transmission plate 61 to slide on the inside of the solution sealing groove 53. When the bubble removal frame 6 slides, the sealing environment formed by the abutment between the bubble removal frame 6 and the grid frame 52 will open, so that the bubbles inside the bubble removal frame 6 will move to the inside of the bubble collection box 51 through the mesh mouth of the grid frame 52.

[0080] As the driving shaft 44 continues to rotate, the bubble removal frame 6 will be continuously subjected to thrust and the reverse thrust of the first spring 626, and will slide back and forth inside the sealing slide groove 53, so that the grid 52 and the bubble removal frame 6 are constantly in an open and closed state, allowing the bubbles to float out quickly while reducing the outflow of the solution.

[0081] It should be noted that: since the bubble removal rack 6 is in a reciprocating sliding state, the bubbles will float out quickly due to the buoyancy when the grid frame 52 and the bubble removal rack 6 are opened, and the rapid closing can avoid the waste of solution. At the same time, the rapid opening and closing of the bubble removal rack 6 can allow the bubbles adsorbed on its surface to be driven by the rapid sliding force, and the bubbles will be thrown off the surface of the bubble removal rack 6, thereby avoiding the presence of bubbles inside the solution collection box 5 and on the surface of the bubble removal rack 6 to affect the operation of the liquid chromatograph.

[0082] It should be noted that when the bubble removal frame 6 is in a stationary state, the mesh opening inside the bubble removal frame 6 and the mesh opening between the mesh frame 52 are in a closed and sealed state.

[0083] The removed bubbles and a small amount of solution contained in the bubbles will be discharged to the outside of the device through the bubble discharge pipe 54, and the solution from which the bubbles have been removed will be transported to the bottom of the device through the solution transport pipe 55.

[0084] When the transmission bent rod 41 rotates, the connecting rod 42 hinged on the outer wall of the transmission bent rod 41 will drive the piston push-pull rod 311 to extend and slide on the inner side of the pump tube 23. During the extension and sliding process of the piston push-pull rod 311, the piston seal 31 will follow the piston push-pull rod 311 to slide on the inner wall of the pump tube 23. When the piston seal 31 slides, the second sealing ring 314 on the outer wall of the piston seal 31 will fit against the inner wall of the pump tube 23, forming a seal between the piston seal 31 and the pump tube 23.

[0085] When the piston seal 31 is pulled to slide toward one side of the sealing block 24, the roller 331 inside the rotary drive member 33 will fit with the inner wall of the pump tube 23 and roll due to the friction between the inner wall of the pump tube 23 and the roller. During the rolling process of the roller 331, the driving cone wheels 332 on both sides of the roller 331 will rotate, driving the transmission cone wheel 334 to rotate. When the transmission cone wheel 334 rotates, the transmission shaft 333 will rotate, the transmission shaft 333 rotates, and the transmission gear 335 will rotate, so that the transmission gear 335 drives the meshing When the driven gear 324 rotates, the hinge rod 323 connected thereto will rotate. When the hinge rod 323 rotates, the valve plate 322 connected thereto will rotate in a direction horizontal to the valve stem 321, so that the valve plate 322 fits against the inner wall of the one-way limit groove 315 to form a seal on the inner side of the through-port 312. When the through-port 312 is sealed, the piston seal 31 slides and presses the solution on the side of the pump tube 23 connected to the infusion tube 26, allowing the solution to be transported to the inner side of the solution collection box 5 through the one-way valve 27 inside the infusion tube 26.

[0086] When the piston seal 31 slides to the top of the sealing block 24 for a return push, the roller 331 will rotate in the opposite direction, driving the transmission cone wheel 334 to rotate, so that the transmission shaft 333 drives the hinge rod 323 to rotate in the opposite direction, and the valve plate 322 connected to the hinge rod 323 rotates, so that the valve plate 322 rotates to a position perpendicular to the valve stem 321, and the one-way limit groove 315 will open at this time. After the one-way limit groove 315 is opened, the piston seal 31 is pushed, and the solution inside the pump tube 23 will pass through the one-way limit groove 315 and the through port 312 to move to the other side of the piston seal 31, so that the solution is collected at one end of the pump tube 23 close to the sealing block 24.

[0087] It should be noted that when the valve plate 322 rotates to the limit, the roller 331 cannot rotate due to resistance, and the roller 331 will slide against the inner wall of the pump tube 23 .

[0088] At the same time, when the piston seal 31 returns, due to the design of the one-way valve 27 at the end of the infusion tube 26 , the solution will not flow to the side of the pump tube 23 connected to the solution chamber 21 .

[0089] And because the double-tube pump group 2 is provided with two groups of pump tubes 23, when a single group of pump tubes 23 returns, the other group of pump tubes 23 will be in a staggered sliding state, so as the transmission crank 41 rotates, the solution inside each solution bottle can be transported to the solution collection box 5.

[0090] At the same time, through the drive of the stepless motor 43, the pulling position of the piston seal 31 can follow with high precision, thereby completing the high-precision delivery of the solution and freely controlling the delivery speed of the solution.

[0091] After the solution enters the solution collection box 5 , the bubbles will be removed through the solution collection box 5 .

[0092] When the bubble removal is completed, the stepless motor 43 is switched to forward rotation, and the forward rotating stepless motor 43 drives the transmission crankshaft 41 to rotate, so that the double-tube pump group 2 transports the solution to the interior of the solution collection box 5 .

[0093] The present invention can simultaneously transport the solution in a bidirectional rotation state, and drive the bubble removal frame 6 to work in a reverse rotation state to automatically remove bubbles, which has higher work efficiency and reduces manual operation. At the same time, the bubbles are separated by the reciprocating sliding of the bubble removal frame 6, so that the bubble removal effect is better and more stable.

[0094] When the stepless motor 43 rotates forward, the end of the driving protrusion 741 will abut against the bottom surface of the transmission guide rod 624, allowing the cam driving member 74 and the transmission guide rod 624 to form a support. At this time, as the driving functional shaft rotates, the cam driving member 74 will slide in the opposite direction of the thread teeth 73, pushing the cam driving member 74 and the thread teeth 73 to gradually separate, and at the same time apply a thrust to the second spring 75. Therefore, when the driving shaft 44 rotates forward, the cam driving member 74 will not apply a driving force to the transmission guide rod 624.

[0095] It should be noted that the meshing position of the threaded teeth 73 is only half the size of the cam driving member 74 itself. After the cam driving member 74 is completely disengaged from the threaded teeth 73, the end of the driving protrusion 741 on the outer wall of the cam driving member 74 is still in contact with the outer wall of the transmission guide rod 624. When it rotates in the opposite direction again, the driving of the bubble removal frame 6 of the bidirectional driving unit 7 can be guaranteed.

[0096] Realize high-precision, high-quality and high-efficiency automated bubble removal in liquid chromatographs.

[0097] The use process of a high performance liquid chromatograph capable of controlling flow rate provided by the present invention is as follows:

[0098] When the equipment is started, the stepless motor 43 will rotate in the reverse direction. When the stepless motor 43 rotates in the reverse direction, the transmission crankshaft 41 will drive the double-tube pump group 2 to work, and the various solutions inside the absorption solution bottle will be continuously transported to the solution collection box 5. The solution will pass through the solution collection box 5 and separate the bubbles from the solution through the bubble removal frame 6, and the separated bubble solution will be discharged through the bubble discharge pipe 54. The solution after the bubbles are removed will be transported to the lower part through the solution delivery pipe 55. When the bubbles in the solution are removed, the stepless motor 43 will be driven to rotate forward. Under forward rotation, the bidirectional drive unit 7 will disengage the transmission from the driven component 62, so that the bubble removal frame 6 and the grid 52 are closed, completing the solution delivery of the equipment.

[0099] It should be noted that the reverse start time of the stepless motor 43 of the present invention can be started according to its own needs, or according to the time when the bubbles need to be removed. When the time after the reverse start of the stepless motor 43 is reached, the stepless motor 43 will rotate forward, so that the equipment is in a working state, and in the forward or reverse rotation state, the curved rod transmission group 4 can drive the solution to be transported, thereby completing the automatic removal of bubbles in the solution without manual operation, with high work efficiency and more stable bubble removal.

[0100] In the present invention, unless otherwise clearly specified and limited, the terms "installed", "connected", "connected", "fixed" and the like should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral one; it can be a mechanical connection, an electrical connection, or communication with each other; it can be a direct connection, or an indirect connection through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements, unless otherwise clearly defined. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0101] Obviously, the embodiments described above are only some embodiments of the present invention, rather than all embodiments. The preferred embodiments of the present invention are given in the accompanying drawings, but they do not limit the patent scope of the present invention. The present invention can be implemented in many different forms. On the contrary, the purpose of providing these embodiments is to make the understanding of the disclosure of the present invention more thorough and comprehensive. Although the present invention has been described in detail with reference to the aforementioned embodiments, for those skilled in the art, it is still possible to modify the technical solutions recorded in the aforementioned specific embodiments, or to perform equivalent replacements for some of the technical features therein. Any equivalent structure made using the contents of the specification and drawings of the present invention, directly or indirectly used in other related technical fields, is also within the scope of patent protection of the present invention.

Claims

1. A high performance liquid chromatograph capable of controlling flow rate, characterized in that: The apparatus comprises an instrument body (1), wherein a double-tube pump group (2) is arranged on the upper side of the inside of the instrument body (1), wherein the double-tube pump group (2) is provided with four groups, wherein a one-way piston (3) is passed through the inside of the double-tube pump group (2), wherein the outer surface of the one-way piston (3) is sealed and slides on the inner wall of the double-tube pump group (2), wherein a bent rod transmission group (4) is arranged on one side of the double-tube pump group (2), wherein a bent rod in the middle of the bent rod transmission group (4) is hinged to the end of the one-way piston (3), and the bent rod transmission group (4) is away from the one-way piston A solution collection box (5) is provided on one side of the double-tube pump group (2), one side of the top of the double-tube pump group (2) is in one-way communication with the interior of the solution collection box (5), a bubble removal rack (6) is slidably connected to the inside of the solution collection box (5), one end of the bubble removal rack (6) slides on the outside of the solution collection box (5), two ends of the curved rod transmission group (4) are provided with a bidirectional driving part (7), and when the curved rod transmission group (4) is in a reverse driving state, the bidirectional driving part (7) is in driving connection with the bubble removal rack (6).

2. A high performance liquid chromatograph capable of controlling flow rate according to claim 1, characterized in that: The instrument body (1) comprises a solvent bottle bracket (11), a pump group (12) is provided on the bottom surface of the solvent bottle bracket (11), a filter (13) is provided on the bottom surface of the pump group (12), a sample group (14) is provided on the bottom surface of the filter (13), a chromatographic column (15) is provided on the bottom surface of the sample group (14), a column temperature box (16) is provided on the bottom surface of the chromatographic column (15), and the double-tube pump group (2), the crankshaft transmission group (4), and the solution collection box (5) are located inside the pump group (12).

3. A high performance liquid chromatograph capable of controlling flow rate according to claim 2, characterized in that: The double-tube pump assembly (2) comprises a solution chamber (21), wherein the solution chamber (21) is provided with four groups, the top of the solution chamber (21) is connected with a bottle connecting tube (22), one end of the bottle connecting tube (22) facing away from the solution chamber (21) is inserted into the inner side of the solvent bottle bracket (11), one side of the solution chamber (21) is connected with a symmetrical pump tube (23), the one-way piston (3) is inserted into the pump tube (23), and one end of the pump tube (23) facing away from the solution chamber (21) is fixed with a A sealing block (24), wherein the sealing block (24) is provided with first sealing rings (25) arranged at equal intervals, one end of the one-way piston (3) is inserted into the sealing block (24) and slides in close contact with the first sealing ring (25), the top surface of one end of the pump tube (23) connected to the sealing block (24) is connected to an infusion tube (26), the other end of the infusion tube (26) is connected to the solution collection box (5), and one end of the infusion tube (26) connected to the pump tube (23) is provided with a one-way valve (27).

4. A high performance liquid chromatograph capable of controlling flow rate according to claim 3, characterized in that: The one-way piston (3) comprises a piston seal (31), a double-plate valve (32), and a rotary drive member (33). The piston seal (31) is located inside the pump tube (23). A piston push-pull rod (311) is connected to the middle of one end of the piston seal (31). The end of the piston push-pull rod (311) away from the piston seal (31) is inserted into the inner side of the sealing block (24) and slides in close contact with the first sealing ring (25). The end of the piston push-pull rod (311) away from the piston seal (31) is hinged to the crankshaft transmission group (4). A through hole (312) is provided at the center of the piston seal (31). Two symmetrical sets of sealing members are provided on both sides of the outer wall of the one-way piston (3). A sealing ring groove (313) is provided inside the sealing ring groove (313), the outer wall of the second sealing ring (314) is in contact with the inner surface of the pump tube (23), the double-piece valve (32) is connected to the middle part of the inner side of the through port (312), a one-way limiting groove (315) is provided at the position where the through port (312) is connected to the double-piece valve (32), the two ends of the double-piece valve (32) are in contact with the inner wall of the one-way limiting groove (315), the rotating driving member (33) is located at both sides of the outer wall of the piston sealing member (31), the outer wall of one side of the rotating driving member (33) is slidably connected to the inner wall of the pump tube (23), and the two ends of the rotating driving member (33) are drivingly connected to the double-piece valve (32).

5. A high performance liquid chromatograph capable of controlling flow rate according to claim 4, characterized in that: The double-plate valve (32) comprises a valve stem (321), the two ends of the valve stem (321) are fixed to the inner wall of the one-way limiting groove (315), symmetrical valve plates (322) are hinged on both sides of the middle of the valve stem (321), the ends of the valve plates (322) are externally abutted against the inner wall of the one-way limiting groove (315), a hinge rod (323) is provided at the hinged position of the valve plate (322) and the valve stem (321), the two ends of the hinge rod (323) are passed through the outer sides of the two ends of the valve stem (321), and driven gears (324) are fixed to the two ends of the hinge rod (323), and the driven gears (324) are meshed with the rotating driving member (33) for transmission.

6. A high performance liquid chromatograph capable of controlling flow rate according to claim 5, characterized in that: The rotary drive member (33) comprises a roller (331), wherein the roller (331) is rotatably connected to the inside of both sides of the piston seal (31), and the outer surface of the roller (331) is in contact with the inner wall of the pump pipe (23); the two ends of the roller (331) located inside the piston seal (31) are connected to driving cone wheels (332); the position inside the piston seal (31) connected to the driving cone wheel (332) is rotatably connected to a transmission shaft (333); a transmission cone wheel (334) is fixed to one end of the transmission shaft (333) close to the driving cone wheel (332), and the transmission cone wheel (334) is meshed with the driving cone wheel (332) for transmission; a transmission gear (335) is fixed to the other end of the transmission shaft (333), and the transmission gear (335) is meshed with the driven gear (324) for transmission.

7. A high performance liquid chromatograph capable of controlling flow rate according to claim 1, characterized in that: The crankshaft transmission group (4) comprises a crankshaft transmission rod (41), a connecting rod (42) is hinged in the middle of the crankshaft transmission rod (41), one end of the connecting rod (42) away from the crankshaft transmission rod (41) is hinged to the piston push-pull rod (311), and symmetrical driving shafts (44) are connected to both ends of the crankshaft transmission rod (41), the bidirectional driving part (7) is connected to the outside of the driving shaft (44), one end of the driving shaft (44) is rotatably connected to the inner wall of the pump group part (12), and the other end of the driving shaft (44) is provided with a stepless motor (43), the output end of the stepless motor (43) is transmission-connected to the driving shaft (44), and the stepless motor (43) is fixed inside the pump group part (12).

8. A high performance liquid chromatograph capable of controlling flow rate according to claim 1, characterized in that: The top surface of the solution collection box (5) is provided with a bubble collection box (51), and the bubble collection box (51) is communicated with the top of the inner side of the solution collection box (5). A grid frame (52) is provided at the position where the solution collection box (5) is connected to the bubble collection box (51). The bottom surface of the grid frame (52) is provided with symmetrical sealing grooves (53) at both ends of the solution collection box (5). The bubble removal frame (6) slides inside the sealing grooves (53). The top surface of the bubble collection box (51) is connected with a bubble drainage pipe (54), and the bottom surface of the solution collection box (5) is connected with a solution delivery pipe (55).

9. A high performance liquid chromatograph capable of controlling flow rate according to claim 8, characterized in that: The two ends of the bubble removal frame (6) slide inside the sealing slide groove (53), and the middle part of the bubble removal frame (6) slides in contact with the bottom surface of the grid frame (52). The two ends of the bubble removal frame (6) sliding inside the sealing slide groove (53) are connected to a transmission plate (61), and one end of the transmission plate (61) is slidably arranged outside the solution collection box (5). The end of the transmission plate (61) located outside the solution collection box (5) is connected to a driven component (62), and the driven component (62) includes a fixed box (621), and the fixed box (621) is fixed to the outer wall of the solution collection box (5). The end of the transmission plate (61) located outside the solution collection box (5) is arranged to be arranged on the fixed box (621). 21), a guide rod sliding groove (622) is provided in the middle of the inner side of the fixed box (621), a guide rod limiting groove (623) is provided in the guide rod sliding groove (622) near the transmission plate (61), a transmission guide rod (624) is slidably provided in the inner side of the guide rod sliding groove (622), limiting blocks (625) are fixed on both sides of the middle part of the transmission guide rod (624), the limiting blocks (625) slide in the inner side of the guide rod limiting groove (623), one end of the transmission guide rod (624) is fixedly connected to the transmission plate (61), a first spring (626) is provided in the guide rod limiting groove (623), and one end of the first spring (626) abuts against the outer wall of the limiting block (625).

10. A high performance liquid chromatograph capable of controlling flow rate according to claim 9, characterized in that: The bidirectional driving part (7) comprises a driving retaining ring (71), the driving retaining ring (71) being fixed to a side of the driving shaft (44) connected to the transmission crankshaft (41), a reset retaining ring (72) being provided on a side of the driving retaining ring (71) away from the driving shaft (44), a threaded tooth (73) being provided on an outer wall of a position where the driving shaft (44) is connected to the driving retaining ring (71), a cam driving member (74) being screwed and engaged with an outer thread of the threaded tooth (73), and a reset retaining ring (72) being provided on a side close to the driving retaining ring (71). A second spring (75) is provided, one end of the second spring (75) facing away from the reset retaining ring (72) is in contact with the cam driving member (74), a driving protrusion (741) is fixed to one side of the outer wall of the cam driving member (74), the driving protrusion (741) is in contact with the end of the transmission guide rod (624), a spring limiting ring (742) is fixed to one side of the cam driving member (74) connected to the second spring (75), and one end of the second spring (75) connected to the cam driving member (74) is located on the inner side of the spring limiting ring (742).

Images