Mould support unit for manufacturing microstructure and microstructure manufacturing apparatus including same

Abstract

A mold support unit is disclosed. The mold support unit includes: a support plate that supports a mold for manufacturing a microstructure, and a plurality of support regions on which the mold is placed are spaced apart from each other and formed, in which the support regions include: a first support region on which an upper surface on which the mold is placed is arranged at a first angle; and a second support region on which an upper surface of the mold is placed at a second angle different from the first angle.

Description

Technical Field

[0001] The present invention relates to a mold support unit for microstructure manufacturing and a microstructure manufacturing device including the same, and more particularly, to a mold support unit for microstructure manufacturing that can fill a composition into a mold using centrifugal force and a microstructure manufacturing device including the same. Background Art

[0002] The routes of administration for delivering drugs to the body include oral, injection, transdermal, etc. Oral administration is a convenient way of administration that can improve the patient's medication compliance, and the active ingredient is delivered to the body in the form of capsules, tablets, and syrups. However, the active ingredient may also be inactivated by first-pass metabolism in the liver, and in fact, the absorption rate of biopharmaceuticals is low. Therefore, in order to show the accurate and rapid efficacy of drugs and therapeutic agents, the drug is administered to the human body by penetrating the skin barrier with an injection. In the case of injection delivery, there is the advantage that the activity of the active ingredient is maintained, but there are the disadvantages of risk of infection, inaccurate volume administration, phobia, pain, etc.

[0003] In order to overcome the limitations of existing oral and injection routes of drug administration, various microstructure transdermal drug delivery systems including minimal permeation microneedles have been developed. Microstructures are mainly prepared in biodegradable (Biodegradable / dissolving), solid (solid), coated (coating), and hollow (hollow) forms. Biodegradable microstructures are transdermal delivery systems that formulate various substances including polymers and active ingredients (active pharmaceutical ingredients (API: Active pharmaceutical ingredient) / cosmetics or pharmaceuticals) into microneedle forms, and after being inserted into the skin, the substances carried are dissolved by body fluids, thereby enabling painless drug delivery.

[0004] As a method for producing the microstructure, a mold casting method is used. In the mold casting method, a composition is filled into a mold using centrifugal force or vacuum and then dried.

[0005] However, in the vacuum utilization method, the composition does not diffuse to the mold top cover, or bubbles are generated in the composition due to the vacuum, which causes problems in uniformity of microstructure production.

[0006] And, in the centrifugal force utilization mode, the mold located in the rotation radius direction of the rotating device is accurately filled with the composition, but in the mold not located in the rotation radius direction, the phenomenon of the composition tilting to one side occurs. In order to solve this problem, more compositions are loaded into the mold to prepare the microstructure, and as the amount of the composition increases, the base of the microstructure thickens. When the thickness of the base thickens, the elasticity of the microstructure array is reduced, so that the possibility that the microneedle cannot be accurately inserted into the skin is large, and the problem that the pharmaceutical products carried cannot be quantitatively delivered is generated.

[0007] There is a need for a method for preparing microstructures that can overcome the limitations of the existing microstructure preparation methods, can be mass-produced, can carry quantitative drugs, and can prepare microstructures with high uniformity. Summary of the invention

[0008] Technical issues

[0009] The present invention provides a mold support unit for producing a microstructure, which can uniformly fill a composition in the entire area of ​​a mold, and a microstructure production device including the same.

[0010] Technical Solution

[0011] The mold support unit according to the present invention includes: a support plate, which supports a mold for manufacturing a microstructure, and support areas for placing the mold are separated from each other and formed in plurality, wherein the support areas include: a first support area, where the upper surface of the mold is placed and arranged at a first angle; and a second support area, where the upper surface of the mold is placed and arranged at a second angle different from the first angle.

[0012] Furthermore, the support area may further include: a third support area, where the upper surface of the mold is placed at a third angle different from the first angle and the second angle.

[0013] Furthermore, the upper surface of the first supporting area can be arranged parallel to the upper surface of the supporting plate, the upper surface of the second supporting area can be arranged inclined at the second angle relative to the upper surface of the supporting plate, and the upper surface of the third supporting area can be arranged inclined at the third angle relative to the upper surface of the supporting plate.

[0014] Furthermore, the third supporting region may be located on an opposite side of the second supporting region across the first supporting region, and an upper surface of the second supporting region and an upper surface of the third supporting region may be symmetrical with respect to the first supporting region.

[0015] Furthermore, the first supporting area, the second supporting area, and the third supporting area may be sequentially arranged along a direction, and the third angle relative to the upper surface of the supporting plate may be greater than the second angle.

[0016] Furthermore, the invention may further include: a loading plate having a plurality of openings formed inwardly so that the supporting areas can be inserted independently, and a supporting platform for placing the mold is formed on the inner side surface of the openings.

[0017] Furthermore, the support areas may correspond to the openings in a one-to-one manner.

[0018] Furthermore, a plurality of supporting legs extending downward by a predetermined length may be formed on the bottom surface of the supporting plate.

[0019] Also, a plurality of the support plates may be stacked in an up-down direction, and the support legs may be placed on the upper surfaces of the support plates located below them.

[0020] The microstructure manufacturing device of the present invention may include: a rotating unit, which can rotate around a first rotating axis; and a mold supporting unit, which is combined with the rotating unit at a predetermined distance from the first rotating axis, can rotate relative to the rotating unit around a second rotating axis, and supports a mold for microstructure manufacturing, wherein the mold supporting unit includes: a supporting plate, which forms a supporting area for placing the mold, wherein, by means of the centrifugal force of the rotating unit rotating around the first rotating axis, the mold supporting unit rotates around the second rotating axis so that the supporting area faces the first rotating axis.

[0021] Also, a plurality of the mold supporting units may be arranged in a ring shape with the first rotation axis as a center, and may be located at the same distance from the first rotation axis.

[0022] Furthermore, the supporting area may include: a first supporting area where an upper surface of the mold is placed at a first angle; and a second supporting area where an upper surface of the mold is placed at a second angle different from the first angle.

[0023] Also, an upper surface of the first supporting region may be parallel to an upper surface of the supporting plate, and an upper surface of the second supporting region may be arranged to be inclined at the second angle relative to an upper surface of the supporting plate.

[0024] Also, an upper surface of the first supporting region may be arranged in parallel with an upper surface of the supporting plate, and an upper surface of the second supporting region may be arranged obliquely with respect to an upper surface of the supporting plate.

[0025] Furthermore, the mold supporting unit may further include a loading plate having an opening formed inwardly thereof into which the supporting area can be inserted, and a supporting platform for placing the mold formed on an inner side of the opening.

[0026] Beneficial Effects

[0027] According to the present invention, when the rotating unit rotates around the first rotating axis, the mold placed in the supporting area of ​​the support plate is arranged toward the first rotating axis. By means of the centrifugal force of the rotating unit, the composition is spread to each area of ​​the mold with a predetermined thickness and can be accurately filled in the needle groove of the mold. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] Figure 1 FIG. 1 is a diagram showing a microstructure manufacturing apparatus according to an embodiment of the present invention.

[0029] Figure 2 It is shown Figure 1 FIG. 1 is a diagram showing a high-speed rotation state of a microstructure manufacturing apparatus.

[0030] Figure 3 FIG. 1 is a diagram showing a microstructure manufacturing apparatus according to another embodiment of the present invention.

[0031] Figure 4 It is shown Figure 3 Diagram of the mold support unit.

[0032] Figure 5 It is shown Figure 4 FIG. 4 is a diagram showing the rotation state of the microstructure manufacturing apparatus.

[0033] Figure 6 is a diagram showing a support plate according to another embodiment of the present invention.

[0034] Figure 7 It shows the use of Figure 4 Figure 2 is an example of a mold support unit to fabricate a microstructure.

[0035] Figure 8 : is a figure which shows the microstructure manufactured using the mold support unit according to the comparative example.

[0036] Fig. 9 is a plan view showing a mold supporting unit according to another embodiment of the present invention.

[0037] Fig.10 It is shown Fig. 9 Cross-sectional view of the mold support unit.

[0038] Fig.11 is a diagram showing a mold supporting unit according to still another embodiment of the present invention.

[0039] Fig.12 It is shown Fig.11 Exploded view of the mold support unit.

[0040] Fig.13 is a diagram showing a mold supporting unit according to still another embodiment of the present invention.

[0041] Fig.14 It is shown Fig.13 A diagram of a state in which a plurality of mold support units are stacked.

[0042] Fig.15 It is shown Fig.13 FIG. 1 is a diagram showing a state in which the mold support unit is rotated 90 degrees around the second rotation axis.

[0043] Fig.16 is a diagram showing a mold supporting unit according to still another embodiment of the present invention.

[0044] Fig.17 FIG. 1 is a diagram showing a microstructure manufacturing apparatus according to still another embodiment of the present invention.

[0045] Fig.18 FIG. 1 is a diagram showing a microstructure manufacturing apparatus according to still another embodiment of the present invention. DETAILED DESCRIPTION

[0046] Hereinafter, the preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings. However, the technical idea of ​​the present invention is not limited to the embodiments described herein, and may also be embodied in other forms. On the contrary, the embodiments introduced herein are provided to make the disclosed contents thorough and complete, and to fully convey the idea of ​​the present invention to those skilled in the art.

[0047] In this specification, when a component is mentioned to be located on another component, it means that it can be directly formed on the other component, or a third component can be interposed between them. In addition, in the drawings, the thickness of the film and the region is exaggerated for the purpose of effectively explaining the technical content.

[0048] Furthermore, in various embodiments of this specification, the terms first, second, third, etc. are used to describe various constituent elements, but these constituent elements are not limited to the above terms. These terms are only used to distinguish a certain constituent element from other constituent elements. Therefore, a constituent element mentioned as a first constituent element in a certain embodiment may also be mentioned as a second constituent element in another embodiment. Each embodiment described and illustrated herein also includes its complementary embodiment. Furthermore, in this specification, "and / or" is used to mean at least one of the constituent elements listed before and after.

[0049] In this specification, unless the context clearly stipulates otherwise, the singular expression includes the plural expression. In addition, the terms such as "including" or "having" are used to specify the existence of features, numbers, steps, operations, constituent elements, parts or their combinations recorded in the specification, and do not preclude the existence or additional possibility of one or more other features or numbers, steps, operations, constituent elements, parts or their combinations. In addition, in this specification, "connected" includes the case of indirectly connecting multiple constituent elements and the case of directly connecting multiple constituent elements.

[0050] Furthermore, in the following description of the present invention, if it is determined that a detailed description of a related well-known function or configuration may unnecessarily obscure the gist of the present invention, the detailed description thereof will be omitted.

[0051] The microstructure manufacturing device of various embodiments described below can manufacture a microstructure that can deliver drugs to the body. The microstructure is a structure that combines a thin base layer (Base layer) and a plurality of needles (needles) formed on a surface of the base layer, wherein the needles can be inserted into skin tissue to deliver drugs. This microstructure is manufactured by filling a composition in the needle groove of a mold for microstructure manufacturing (hereinafter referred to as a "mold"). The composition can be a biocompatible or biodegradable substance. Biocompatible or biodegradable substances are substantially non-toxic, chemically inert, and non-immunogenic substances to the human body, and have the advantage of finally penetrating into the body and then dissolving.

[0052] The type of such biocompatible material is not particularly limited, and for example, hyaluronic acid, polyester, polyhydroxyalkanoate (PHAs: polyhydroxyalkanoate), poly (α-hydroxy acid), poly (β-hydroxy acid), poly (3-hydroxybutyrate-co-hydroxyvalerate (PHBV: poly (3-hydroxybutyrate-co-hydroxyvalerate)), poly (3-hydroxypropionate) (PHP: poly (3-hydroxypropionate)), poly (3-hydroxyhexanoate) (PHH: poly (3-hydroxyhexanoate)), poly (4-hydroxy acid), poly (4-hydroxybutyrate), poly (4-hydroxyvalerate), poly (4-hydroxyhexanoate) can be used. , poly(esteramide), polycaprolactone, polylactide, polyglycolide, poly(lactide-co-glycolide) (PLGA: poly(lactide-co-glycolide)), polydioxanone, polyorthoester, polyetherester, polyanhydride, poly(glycolide-co-trimethylene carbonate), polyphosphate, polyphosphate urethane, poly(amino acid), polycyanoacrylate, poly(trimethylene carbonate), poly(imino carbonate), poly(tyrosine carbonate), polycarbonate, poly(tyrosine arylate), poly(alkylene oxalate), polyphosphate, phytohemagglutinin-polyethylene glycol (PHA-PEG: phytohemagglutinin-polyethylene glycol), ethylene-vinyl alcohol copolymer (EVOH: ethylene , vinyl alcohol copolymer), polyurethane, silicone, polyester, polyolefin, polyisobutylene and ethylene-alpha olefin copolymer, styrene-isobutylene-styrene triblock copolymer, acrylic polymers and copolymers, vinyl halide polymers and copolymers, polyvinyl chloride, polyvinyl ether, polyvinyl methyl ether, polyvinylidene halide, polyvinylidene fluoride, polyvinylidene chloride, polyfluoroalkane, polyperfluoroalkane, polyacrylonitrile, polyvinyl ketone, polyvinyl aromatic hydrocarbon, polystyrene, polyvinyl ester, polyvinyl acetate, ethylene-methyl methacrylate copolymer, acrylonitrile-styrene copolymer, ABS resin and ethylene-vinyl acetate copolymer, polyamide, alkyd resin, polyoxymethylene, polyimide, polyether, polyacrylate, polymethacrylate, poly(acrylic acid-co-maleic acid), chitosan, dextran, cellulose, heparin, alginate, inulin, starch or glycogen,Alternatively, one or more selected from the group consisting of hyaluronic acid, polyester, polyhydroxyalkanoate (PHAs), poly(α-hydroxy acid), poly(β-hydroxy acid), poly(3-hydroxybutyrate-co-hydroxyvalerate) (PHBV: poly(3-hydroxybutyrate-co-hydroxyvalerate)), poly(3-hydroxypropionate) (PHP: poly(3-hydroxypropionate)), poly(3-hydroxyhexanoate) (PHH: poly(3-hydroxyhexanoate)), poly(4-hydroxy acid), poly(4-hydroxybutyrate), poly(4-hydroxypentanoate) can be used. esters), poly(4-hydroxyhexanoate), poly(esteramides), polycaprolactone, polylactide, polyglycolide, poly(lactide-co-glycolide) (PLGA: poly(lactide-co-glycolide)), polydioxanone, polyorthoesters, polyetheresters, polyanhydrides, poly(glycolide-co-trimethylene carbonate), polyphosphates, polyphosphate urethanes, poly(amino acids), polycyanoacrylates, poly(trimethylene carbonate), poly(imino carbonate), poly(tyrosine carbonate), polycarbonate, poly(tyrosine arylate), poly(alkylene oxalate), polyphosphates, phytohemagglutinin-polyethylene glycol (PHA-PEG: phytohemagglutinin-polyethylene glycol), chitosan, dextran, cellulose, heparin, alginate, inulin, starch and glycogen.

[0053] In the case where the microstructure is a solid microneedle equipped with a biocompatible or biodegradable substance, a drug can be additionally carried. The drug refers to a broad concept, including not only therapeutic agents for narrow therapeutic purposes, but also energy, nano ingredients, beauty ingredients (for example, wrinkle improvers, skin aging inhibitors and skin whitening agents), cell culture fluids, etc.

[0054] Specifically, the therapeutic agent includes chemical drugs, protein / peptide drugs, peptide drugs, nucleic acid molecules for gene therapy, etc.

[0055] For example, therapeutic agents may include anti-inflammatory agents, analgesics, anti-arthritic agents, antispasmodics, antidepressants, antipsychotics, neurostabilizers, antianxiety agents, narcotic antagonists, anti-Parkinson's disease drugs, cholinergic agonists, anticancer agents, anti-angiogenesis inhibitors, immunosuppressants, antiviral agents, antibiotics, appetite suppressants, analgesics, anticholinergics, antihistamines, anti-migraine drugs, hormonal agents, coronary, cerebrovascular or peripheral vasodilators, contraceptives, antithrombotic agents, diuretics, antihypertensive agents, cardiovascular disease therapeutics, etc.

[0056] In particular, protein / peptide drugs may include hormones, hormone analogs, enzymes, enzyme inhibitors, signal transduction proteins or portions thereof, antibodies or portions thereof, single-chain antibodies, binding proteins or binding domains thereof, antigens, attachment proteins, structural proteins, regulatory proteins, toxin proteins, cytokines, transcriptional regulators, coagulation factors, vaccines, and the like. In more detail, protein / peptide drugs may include insulin, insulin-like growth factor 1 (IGF-1), growth hormone, erythropoietin, granulocyte colony stimulating factor (G-CSF), granulocyte / macrophage colony stimulating factor (GM-CSF), interferon α, interferon β, interferon γ, interleukin-1α and β, interleukin-3, interleukin-4, interleukin-6, interleukin-2, epidermal growth factor (EGFs: epidermal growth factors), calcitonin, adrenocorticotropic hormone (ACTH: adrenocorticotropichormone), tumor necrosis factor (TNF: tumor necrosis factor factor), atobisban, buserelin, cetrorelix, deslorelin, desmopressin, dynorphin A (1-13), elcatonin, eleidosin, eptifibatide, growth hormone releasing hormone-II (GHRH-II: growth hormone releasing hormonehormone-II), gonadorelin, goserelin, histrelin, leuprorelin, lypressin, octreotide, oxytocin, pitressin, secretin, sincalide, terlipressin, thymopentin, thymosine α1, triptorelin, bivalirudin, carbetocin, cyclosporine, exedine, lanreotide, luteinizing hormone-releasing hormone (LHRH: uteinizing hormone-releasing hormone hormone), nafarelin, parathyroid hormone, pramlintide, enfuvirtide (T-20), thymalfasin, and ziconotide.

[0057] The mold can have a variety of shapes. In the accompanying drawings of the present invention, the mold is shown as a quadrilateral shape, but it is not limited to this. The mold can have a circular or polygonal shape. According to the shape of this mold, a quadrilateral, circular and polygonal base layer can be manufactured.

[0058] Hereinafter, the microstructure manufacturing apparatus according to the present invention will be described in detail.

[0059] Figure 1 is a diagram showing a microstructure manufacturing apparatus according to an embodiment of the present invention, Figure 2 It is shown Figure 1 FIG. 1 is a diagram showing a high-speed rotation state of a microstructure manufacturing apparatus.

[0060] Reference Figure 1 and Figure 2 The microstructure manufacturing apparatus 10 includes a rotating unit 100 and a mold supporting unit 200 .

[0061] The rotating unit 100 is a structure that can rotate around the first rotating shaft 20, and can be set in various shapes. According to one embodiment, the rotating unit 100 can be set as a circular plate that can rotate around the first rotating shaft 20. According to another embodiment, the rotating unit 100 can be set as a circular frame that can rotate around the first rotating shaft 20. The first rotating shaft 20 can be set perpendicular to the ground.

[0062] The rotating unit 100 is formed with a receiving space 110 in which the mold supporting unit 200 can be placed. According to an embodiment, a plurality of receiving spaces 110 are formed and arranged in a circle around the first rotating shaft 20. Each receiving space 110 may be located at the same distance from the first rotating shaft 20.

[0063] The mold support unit 200 supports the mold 50. The mold support units 200 are respectively located in the receiving spaces 110 and are combined with the rotating unit 100 in a manner that they can rotate around the second rotating shaft 30. The second rotating shaft 30 is arranged along the arrangement direction of the mold support units 200 (i.e., the direction tangent to the circle). The second rotating shaft 30 may be arranged perpendicular to the rotation radius direction of the mold support unit 200.

[0064] The mold support unit 200 includes a support plate 210. The support plate 210 is a thin plate having a predetermined area, and has a support region 211 formed on one surface. The mold 50 is placed on the upper surface of the support region 211. The upper surface of the support region 211 is set to be a flat surface.

[0065] In a state where the mold 50 is placed on the support area 211, the composition 60 is supplied to the upper surface of the mold 50. The composition 60 cannot be directly put into the needle groove 51 of the mold 50 due to its high viscosity. In this state, if the rotating unit 100 rotates at a high speed with the first rotating shaft 20 as the center, the mold support unit 200 rotates 90 degrees with the second rotating shaft 30 as the center by centrifugal force, so that the support plate 210 is arranged perpendicular to the rotation radius direction of the rotating unit 100, and the support area 211 is arranged toward the first rotating shaft 20. The centrifugal force of the rotating unit 100 acts perpendicularly on the upper surface of the mold 50 and spreads radially, so that the composition 60 can be evenly spread to each area of ​​the mold 50 and put into the needle groove 51. The composition 60 can penetrate deeply into the needle groove 51 along the centrifugal force direction of the rotating unit 100.

[0066] Figure 3 2 is a diagram showing a microstructure manufacturing apparatus according to another embodiment of the present invention, Figure 4 It is shown Figure 3 Figure 1. Diagram of the mold support unit. Figure 5 It is shown Figure 4 FIG. 4 is a diagram showing the rotation state of the microstructure manufacturing apparatus.

[0067] First, refer to Figure 3 and Figure 4A plurality of receiving spaces 110 are formed in the rotating unit 100. According to an embodiment, four receiving spaces 110 are formed and arranged at an angle of 90 degrees. The receiving spaces 110 are formed with a predetermined length and arranged such that the length direction thereof is perpendicular to the radius direction of the rotating unit 100.

[0068] The mold support unit 200 is respectively located in the receiving space 110, and is combined with the rotating unit 100 in a manner that it can rotate around the second rotating shaft 30. The mold support unit 200 includes a support plate 210. The support plate 210 has an area corresponding to the receiving space 110, and a plurality of support areas 211, 212, and 213 are formed on one surface. The mold 50 is placed in the support areas 211, 212, and 213, respectively. According to an embodiment, three support areas 211, 212, and 213 are provided on the upper surface of the support plate 210, and the first support area 211 is located in the center of the support plate 210. The second support area 212 and the third support area 213 are respectively located on both sides of the first support area 211.

[0069] The upper surface of the first support area 211 is arranged at a first angle θ1. According to an embodiment, the first angle 211 is an angle of 0° with the upper surface of the support plate 210, and the upper surface of the first support area 211 is arranged parallel to the upper surface of the support plate 210.

[0070] The upper surface of the second support area 212 is arranged at a second angle θ2. The second angle θ2 is an angle different from the first angle θ1, and can form an angle greater than 0° and less than 90° with the upper surface of the support plate 210 based on the center of the support plate 210. According to an embodiment, the second angle θ2 can form an angle greater than 1° and less than 60° with the upper surface of the support plate 210. Thus, the upper surface of the second support area 212 can be arranged obliquely at the second angle θ2 relative to the upper surface of the support plate 210. Specifically, the second support area 212 is arranged so that the front end adjacent to the first support area 211 is lower than the height of the rear end, so that the upper surface is arranged to be inclined downward at the second angle θ1 toward the side of the first support area 211.

[0071] The upper surface of the third support area 213 is arranged at a third angle θ3. The third angle θ3 is an angle different from the first angle θ1 and the second angle θ2, and can form an angle greater than 90° and less than 180° with the upper surface of the support plate 210 based on the center of the support plate 210. According to an embodiment, the third angle θ3 can form an angle greater than 91° and less than 150° relative to the upper surface of the support plate 210. Therefore, the upper surface of the third support area 213 can be arranged obliquely at the third angle θ3 relative to the upper surface of the support plate 210. Specifically, the third support area 213 is provided so that the front end adjacent to the first support area 211 is lower than the height of the end, and is arranged so that the upper surface is inclined downward at the third angle θ3 toward the side of the first support area 211. The upper surface of the third support area 213 can be symmetrical with the upper surface of the second support area 212 with the first support area 211 as the center.

[0072] Reference Figure 5 , if the rotating unit 100 rotates at a high speed with the first rotating shaft 20 as the center, the mold supporting unit 200 rotates 90 degrees with the second rotating shaft 30 as the center by centrifugal force, so that one surface of the supporting plate 210 is arranged perpendicular to the rotation radius direction of the rotating unit 100. At this time, with the virtual circle 70 whose radius is the shortest distance r connecting the upper surfaces of the respective supporting areas 211, 212, and 213 in the first rotating shaft 20 as the reference, the upper surfaces of the supporting areas 211, 212, and 213 are arranged along the tangent direction of the virtual circle 70. Therefore, the centrifugal force of the rotating unit 100 is provided perpendicular to the upper surface of the mold 50, so that the composition 60 can be evenly spread to each area of ​​the mold 50.

[0073] In this embodiment, the case where three support areas 211, 212, and 213 are provided on the support plate 210 is described, but the number of support areas can be changed in many ways. Figure 6 , nine support areas 211 to 219 may be provided on the support plate 210. With the first support area 211 located in the center of the support plate 210 as a reference, four support areas 212 to 219 may be provided on both sides. The upper surfaces of the support areas 211 to 219 are arranged at different angles from each other, and the angles gradually increase as they are away from the center of the support plate 210. In addition, the inclination angles of the support areas 212 to 219 may be symmetrical to each other with respect to the first support area 211 as a reference.

[0074] Figure 7 It shows the use of Figure 4 FIG. 1 is a diagram of an embodiment of a mold support unit to manufacture a microstructure. Figure 83 is a diagram showing a microstructure manufactured using a mold support unit according to a comparative example. In the mold support unit 300 according to the comparative example, the upper surfaces of the first support region 311 to the third support region 313 are all set to be flat surfaces.

[0075] First, refer to Figure 7 It can be confirmed that since the centrifugal force of the rotating unit 100 is provided in a direction perpendicular to the upper surface of the first support area 211 to the third support area 213, the compositions 61, 62, and 63 can be evenly spread to various areas of the mold 50 and evenly put into the needle groove 51.

[0076] On the contrary, refer to Figure 8 In the mold 50 placed in the first support area 311, the composition 71 is uniformly spread, but it can be confirmed that the compositions 72 and 73 are concentrated in the outer contour area in the mold 50 placed in the second support area 312 and the third support area 313. This is understood to be the result of the composition 72 and 73 being spread in the centrifugal force direction of the rotating unit 100 because the upper surfaces of the second support area 312 and the third support area 313 are not arranged toward the first rotating shaft 20.

[0077] Fig. 9 is a plan view showing a mold support unit according to another embodiment of the present invention, Fig.10 It is shown Fig. 9 Cross-sectional view of the mold support unit.

[0078] Reference Fig. 9 and Fig.10 In the support plate 100 of the mold support unit 200, the first to third support areas 211 to 213 may be arranged in a plurality of rows. Along the Y-axis direction, the first support areas 211 are arranged in a row, the second support areas 212 are arranged in a row, and the third support areas 213 are arranged in a row. The upper surface of the first support area 211 is arranged in a flat plane, the upper surface of the second support area 212 is arranged at an angle of the second angle, and the upper surface of the third support area 213 is arranged at an angle of the third angle.

[0079] When a microstructure is manufactured using the mold support unit 200 , a plurality of microstructures can be simultaneously manufactured through one manufacturing process.

[0080] Fig.11 is a diagram showing a mold support unit according to still another embodiment of the present invention, Fig.12 It is shown Fig.11 Exploded view of the mold support unit.

[0081] Reference Fig.11 and Fig.12, the mold supporting unit 200 includes a supporting plate 210 and a loading plate 220 .

[0082] The support plate 210 can be used Figures 3 to 10 One of the support plates described in .

[0083] The loading plate 220 has an area corresponding to the support plate 210, and has a plurality of openings 221, 222, 223. The openings 221, 222, 223 are holes that penetrate the upper and lower surfaces of the loading plate 220, and according to an embodiment, the openings 221, 222, 223 are arranged in a quadrilateral shape. The opening 211 is formed in a position, number and size corresponding to the support areas 211, 212, 213 of the support plate 210. Support protrusions 231, 232, 233 are formed on the inner side surface of the loading plate 220 where the openings 221, 222, 223 are formed. The support protrusions 231, 232, 233 may be formed on at least one pair of inner side surfaces facing each other among the inner side surfaces of the loading plate 220 where the openings 221, 222, 223 are formed. When the mold 50 is inserted into the openings 221 , 222 , 223 , the support protrusions 231 , 232 , 233 support the bottom surface of the mold 50 .

[0084] Hereinafter, a process of placing the mold 50 on the mold supporting unit 200 according to the above embodiment will be described.

[0085] First, in a state where the support plate 210 and the loading plate 220 are separated, the mold 50 is placed in the openings 221, 222, 223 of the loading plate 220. And, in a state where the support plate 210 and the loading plate 220 are placed, the loading plate 220 is moved downward so that the support areas 211, 212, 213 and the openings 221, 222, 223 are located on the same line. In this process, the support areas 211, 212, 213 are inserted into the openings 221, 222, 223, and the mold 50 placed in the openings 221, 222, 223 is placed on the upper surface of the support areas 211, 212, 213.

[0086] As described above, the upper surfaces of some of the support areas 212, 213 are set as inclined surfaces. The inclined surface makes it difficult to place the mold 50 at a predetermined position due to the inclination. In order to solve this problem, the loading plate 220 is used. In a state where the mold 50 is placed in the openings 221, 222, 223 of the loading plate 220, the mold 50 is transferred to the upper surfaces of the support areas 211, 212, 213 through the combination between the loading plate 220 and the support plate 210. In this process, the mold 50 can always be placed at a constant position on the upper surfaces of the support areas 211, 212, 213.

[0087] Fig.13 is a diagram showing a mold support unit according to still another embodiment of the present invention, Fig.14 It is shown Fig.13 A diagram of a state in which a plurality of mold support units are stacked with a plurality of, Fig.15 It is shown Fig.13 FIG. 1 is a diagram showing a state in which the mold support unit is rotated 90 degrees around the second rotation axis.

[0088] Reference Fig.13 and Fig.14 A support leg 240 is formed on the bottom surface of the support plate 210. The support leg 240 is provided downward from the bottom surface of the support plate 210 with a predetermined length. A plurality of support legs 240 are provided, and are arranged at predetermined positions of the support plate 210 and spaced apart from each other.

[0089] The mold support unit 200 having the above structure may be stacked in plurality. Specifically, in the support plate 210 included in the mold support unit 200 located at the upper portion, the support leg 240 is placed on the upper surface of the loading plate 220 of the mold support unit 200 located at the lower portion. The plurality of mold support units 200 stacked in this manner are combined into one by a combining unit (not shown) and can rotate in one piece around the second rotation axis 30.

[0090] The upper surfaces of all the first support areas 211 formed in the mold support unit 200 are arranged in parallel with the upper surface of the support plate 210. The second support area 212 and the third support area 213 are provided with different inclination angles according to the mold support unit 200. Specifically, as the distance from the first rotation axis 20 increases, the inclination angles of the second support area 212 and the third support area 213 gradually decrease. Therefore, the upper surfaces of the second support area 212 and the third support area 213 of the mold support unit 200 located at the lower part have a smaller inclination angle than the upper surfaces of the second support area 212 and the third support area 213 of the mold support unit 200 located at the upper part.

[0091] Reference Fig.15 , when the rotating unit 100 rotates at a high speed around the first rotating shaft 20, the mold supporting unit 200 rotates 90 degrees around the second rotating shaft 30 by centrifugal force, so that the supporting plate 210 is arranged perpendicular to the radial direction of the rotating unit 100. In addition, through the above-mentioned arrangement of the upper surfaces of the first supporting area 211, the second supporting area 212 and the third supporting area 213 at an inclined angle, the upper surfaces of the first supporting area 211, the second supporting area 212 and the third supporting area 213 can be arranged toward the first rotating shaft 20.

[0092] Fig.16 is a diagram showing a mold supporting unit according to still another embodiment of the present invention.

[0093] Reference Fig.16 , the support legs 240 may be formed not only at the bottom edge region of the support plate 210 but also at the central region of the support plate 210. The support legs 240 are placed on the upper surface of the loading plate 220 located below it. The support legs 240 are arranged at predetermined intervals throughout the entire region of the support plate 210, so that the mold can be stably supported during high-speed rotation.

[0094] Fig.17 FIG. 1 is a diagram showing a microstructure manufacturing apparatus according to still another embodiment of the present invention.

[0095] Reference Fig.17 , the mold support unit 200 is fixedly arranged on the second rotating shaft 30 so that the upper surface of the mold 50 faces the first rotating shaft 20. Therefore, when the composition 60 is supplied to the mold 50, or during the high-speed rotation of the rotating unit 100, the upper surface of the mold 50 is always arranged toward the first rotating shaft 20. In the process of supplying the composition 60 to the mold 50, the composition 60 may flow downward due to its own weight. Therefore, the microstructure manufacturing device 10 according to the present embodiment is suitable for a composition 60 with high viscosity. Through the high-speed rotation of the rotating unit 100, a sufficient centrifugal force can be transmitted to the upper surface of the mold 50, so the highly viscous composition 60 can also be spread on the upper surface of the mold 50 with a uniform thickness.

[0096] Fig.18 FIG. 1 is a diagram showing a microstructure manufacturing apparatus according to still another embodiment of the present invention.

[0097] Reference Fig.18 , the rotating unit 100 is arranged so that the first rotating axis 20 is parallel to the ground (XY plane). Therefore, the mold support units 200 are located at different heights from each other with the first rotating axis 20 as the center. Due to the structure of such a rotating unit 100, the composition 60 can be supplied to the mold 50 of the mold support unit 200 disposed at the lower part of the first rotating axis 20. A weight forming fixture 90 may be provided in other mold support units 200 where the composition is not supplied. The weight forming fixture 90 is provided as a structure having the weight of the mold 50 and the composition 60 added together, and is used to align the center of gravity of the rotating unit 100 with the first rotating axis 20 as the center.

[0098] The present invention has been described in detail using preferred embodiments, but the scope of the present invention is not limited to the specific embodiments and should be interpreted according to the scope of the attached claims. Furthermore, it should be understood by those skilled in the art that various modifications and variations may be made without departing from the scope of the present invention.

Claims

1. A mold support unit, as a mold support unit for supporting a mold for manufacturing a microstructure, comprising: A support plate supports a mold for manufacturing a microstructure, and a plurality of support areas where the mold is placed are separated from each other and formed, Wherein, the support area includes: a first support area, where the upper surface of the mold is placed at a first angle; and A second supporting area is provided, where the upper surface of the mold is arranged at a second angle different from the first angle.

2. The mold support unit according to claim 1, wherein: The support area also includes: A third supporting area is provided, where the upper surface of the mold is arranged at a third angle different from the first angle and the second angle.

3. The mold support unit according to claim 2, wherein: The upper surface of the first supporting area is arranged parallel to the upper surface of the supporting plate, The upper surface of the second supporting area is arranged to be inclined at the second angle relative to the upper surface of the supporting plate. An upper surface of the third supporting region is arranged to be inclined at the third angle relative to an upper surface of the supporting plate.

4. The mold support unit according to claim 3, wherein: The third supporting area is located on the opposite side of the second supporting area across the first supporting area. The upper surface of the second supporting area and the upper surface of the third supporting area are symmetrical with respect to the first supporting area.

5. The mold support unit according to claim 2, wherein: The first supporting area, the second supporting area and the third supporting area are arranged in sequence along a direction, Relative to the upper surface of the support plate, the third angle is greater than the second angle.

6. The mold support unit according to claim 1, further comprising: The loading plate has a plurality of openings formed inwardly so that the supporting areas can be inserted independently respectively, and a supporting platform for placing the mold is formed on the inner side surface of the opening.

7. The mold support unit according to claim 6, wherein: The support areas correspond one-to-one to the openings.

8. The mold support unit according to claim 1, wherein: A plurality of supporting legs extending downward by a predetermined length are formed on the bottom surface of the supporting plate.

9. The mold support unit according to claim 8, wherein: A plurality of the support plates are stacked in an up-down direction, and the support legs are placed on the upper surfaces of the support plates located below them.

10. A microstructure manufacturing device, comprising: A rotating unit capable of rotating around a first rotating axis; as well as a mold supporting unit, which is coupled to the rotating unit at a predetermined distance from the first rotating axis, can rotate relative to the rotating unit about the second rotating axis, and supports the mold for manufacturing the microstructure; Wherein, the mold support unit comprises: A support plate, formed with a support area for placing the mold, Wherein, by means of the centrifugal force of the rotating unit rotating around the first rotating axis, the mold supporting unit rotates around the second rotating axis, so that the supporting area faces the first rotating axis.

11. The microstructure manufacturing device according to claim 10, wherein: A plurality of the mold supporting units are arranged in a ring shape around the first rotation axis and are located at the same distance from the first rotation axis.

12. The microstructure manufacturing device according to claim 10, wherein: The support area includes: a first support area, where the upper surface of the mold is placed at a first angle; and A second supporting area is provided, where the upper surface of the mold is arranged at a second angle different from the first angle.

13. The microstructure manufacturing device according to claim 12, wherein: The upper surface of the first supporting area is parallel to the upper surface of the supporting plate, The upper surface of the second supporting area is arranged to be inclined at the second angle relative to the upper surface of the supporting plate.

14. The microstructure manufacturing device according to claim 12, wherein: The upper surface of the first supporting area is arranged parallel to the upper surface of the supporting plate, An upper surface of the second supporting region is arranged obliquely with respect to an upper surface of the supporting plate.

15. The microstructure manufacturing device according to claim 10, wherein: The mold support unit also includes: The loading plate has an opening formed inwardly for inserting the supporting area, and a supporting platform for placing the mold is formed on the inner side of the opening.

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