Microneedle administration device

Abstract

The invention discloses a pressing drug delivery device which can enable pressing drug delivery pressure to be uniform and guarantee effective drug delivery. Meanwhile, the microneedle dosing device is simple in structure and convenient to operate. The microneedle administration device comprises an upper buckle and a lower buckle, the upper buckle comprises a buckle body; a pressing plate is arranged at the upper end of the buckle body; a push block is arranged at the lower end; a microneedle patch is arranged on the push block; a limiting block is arranged at the lower end of the lower buckle; the lower buckle is provided with an inner cavity; the surface of the inner cavity is a conical surface; the limiting block is provided with a central hole; the central hole is communicated with the inner cavity; the diameter of the central hole is matched with that of the microneedle patch; the diameter of the lower end surface of the push block is equal to or smaller than that of the microneedle patch; and a medical double-faced adhesive tape is arranged on the bottom surface of the limiting block. By adopting the microneedle administration device, accurate administration can be realized, effective administration is ensured, and the operation is simple and convenient.

Description

Technical Field

[0001] The present invention belongs to the technical field of medical devices, in particular to a microneedle drug delivery device. Background Art

[0002] Microneedles (MN) are a new type of transdermal delivery system that releases drugs through the skin through tiny needles. The height of the microneedle tip is generally 10 to 2000 μm, and the diameter is 300 to 1000 μm. Microneedles can penetrate the stratum corneum of the skin into the dermis, greatly improving the permeability and penetration of drugs between skin layers. When using microneedles, the microneedle patch is pressed on the human skin by hand or a microneedle introduction instrument, so that the soluble microneedle array penetrates the skin and forms a micron-level drug transmission channel in the skin safely and painlessly, thereby dissolving and releasing the active ingredients such as drugs carried by the soluble microneedle array in the deep layer of the skin, achieving transdermal drug delivery safely and painlessly.

[0003] The existing microneedle drug delivery device includes a microneedle product assembly disclosed in Chinese invention patent application CN 118079221 A. The microneedle product assembly includes a microneedle patch and an introduction instrument. The microneedle patch includes an adhesive sheet, a support sheet, a microsubstrate and a microneedle array. The adhesive surface of the adhesive sheet can be adhered to the support sheet. The support sheet is provided with a slot hole. The microsubstrate is inserted into the slot hole, and the second side of the microsubstrate is adhered to the corresponding area of ​​the adhesive surface and the slot hole. A gripping sheet is provided on the outer periphery of the support sheet protruding from the adhesive sheet. The adhesive sheet has magnetism. The magnetic suction head of the introduction instrument can be mutually adsorbed with the adhesive sheet. The release force between the support surface and the adhesive surface is F1, 1g / mm≤F1≤3g / mm, and the magnetic suction force between the adhesive sheet and the magnetic suction head is F2, F2≥100Gs.

[0004] The above-mentioned microneedle product components use hands to press the microneedles to deliver drugs; it is difficult to achieve uniform and effective drug delivery when the hands press the microneedles to deliver drugs. Since the hands cannot evenly apply force to each part of the microneedles, the needle tips at the edge of the microneedles are difficult to pierce the skin for transdermal drug delivery; the incomplete drug delivery at the needle tip will affect the drug delivery effect of the microneedles. Therefore, drug delivery by pressing the microneedles by hand will lead to improper individual operation, making it difficult to ensure effective drug delivery of the microneedles, let alone achieve precise drug delivery.

[0005] In order to ensure that the microneedles can be completely inserted into the skin, thus ensuring the drug delivery effect, the existing microneedle drug delivery mainly uses adhesive sheets to stick to the skin for transdermal drug delivery. The microneedle backing material is a flexible material, and improper operation during manual separation may easily cause the needle tip to break, thereby affecting the drug delivery effect. Summary of the invention

[0006] The technical problem to be solved by the present invention is to provide a microneedle drug delivery device which can make the drug delivery pressure uniform and ensure effective drug delivery; and at the same time has a simple structure and is easy to operate.

[0007] The technical solution adopted by the present invention to solve the technical problem is: a microneedle drug delivery device, including an upper buckle and a lower buckle; the upper buckle includes a buckle body; a pressure plate is arranged at the upper end of the buckle body; a push block is arranged at the lower end; a microneedle patch is arranged on the push block;

[0008] A limit block is arranged at the lower end of the lower buckle; the lower buckle has an inner cavity; the surface of the inner cavity is a cone; the limit block has a center hole; the center hole is connected to the inner cavity;

[0009] The diameter of the central hole matches the diameter of the microneedle patch; the diameter of the lower end surface of the push block is equal to or smaller than the diameter of the upper end of the microneedle patch; and the bottom surface of the limit block is provided with medical double-sided tape.

[0010] Furthermore, the microneedle patch includes a patch and a support sheet; the patch is provided with a support sheet; the support sheet is provided with uniformly distributed microneedles; the diameter of the patch is larger than the diameter of the support sheet; and the patch uses double-sided tape with different adhesive forces on both sides; one side of the patch is adhered to the push block, and the other side is adhered to the support sheet; when the microneedle patch is attached to the skin, the part of the patch extending out of the support sheet is attached to the skin; and the adhesive force of the side attached to the skin is greater than the adhesive force of the patch attached to the lower surface of the push block.

[0011] Furthermore, the diameter of the lower end surface of the push block is smaller than the maximum diameter of the microneedle patch; and an anti-retraction boss is arranged in the central hole.

[0012] Furthermore, the outer surface of the buckle body or the push block is a conical surface that matches the inner cavity of the lower buckle.

[0013] Furthermore, the push block is detachably connected to the buckle body;

[0014] The lower end of the buckle body is provided with a first connecting boss; the upper surface of the push block is provided with a first connecting groove matching the first connecting boss;

[0015] The limit block is detachably connected to the lower buckle; a second connecting boss is provided on the lower surface of the lower buckle;

[0016] The upper surface of the limiting block is provided with a second connecting groove matching the second connecting boss.

[0017] Specifically, the lower buckle is made of medical elastic material.

[0018] The beneficial effects of the present invention are as follows: the microneedle drug delivery device described in the present invention realizes microneedle drug delivery by adopting an upper buckle and a lower buckle, the lower buckle can accurately locate the drug delivery position, and the upper buckle can make the drug delivery pressure uniform; therefore, the microneedle drug delivery device described in the present invention can realize precise drug delivery and ensure effective drug delivery.

[0019] Secondly, the microneedle drug delivery device described in the present invention still adopts pressing drug delivery during the drug delivery process, thereby making the operation simple and convenient. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 is an exploded schematic diagram of a microneedle drug delivery device according to an embodiment of the present invention;

[0021] Figure 2 This is a front view of the microneedle drug delivery device according to an embodiment of the present invention.

[0022] Figure 3 yes Figure 2 AA section view;

[0023] Figure 4 is a schematic diagram of the structure of the microneedle drug delivery device in an embodiment of the present invention when the upper buckle and the lower buckle are buckled together;

[0024] Figure 5 is an exploded schematic diagram of the upper buckle and the lower buckle of the microneedle drug delivery device in an embodiment of the present invention when they are in a combined manner;

[0025] Figure 6 1 is a front view of the upper buckle and the lower buckle of the microneedle drug delivery device in the embodiment of the present invention when they are in a combined manner;

[0026] Figure 7 yes Figure 6 BB cross-sectional view;

[0027] Figure 8 2 is a schematic diagram of the structure of the microneedle drug delivery device in an embodiment of the present invention when the upper buckle and the lower buckle are combined and buckled;

[0028] Markings in the figure: 100-upper buckle, 110-pressure plate, 120-buckle body, 130-first connecting boss, 200-push block, 210-first connecting groove, 300-lower buckle, 310-inner cavity, 320-second connecting boss; 400-medical double-sided tape, 500-microneedle patch, 510-patch, 520-support sheet, 530-microneedle, 600-limiting block, 610-center hole, 620-anti-retreat boss, 630-second connecting groove. DETAILED DESCRIPTION

[0029] The present invention is further described below in conjunction with the accompanying drawings and embodiments.

[0030] like Figures 1 to 8As shown, a microneedle drug delivery device according to the present invention comprises an upper buckle 100 and a lower buckle 300; the upper buckle 100 comprises a buckle body 120; a pressing plate 110 is arranged at the upper end of the buckle body 120; a push block 200 is arranged at the lower end; a microneedle patch 500 is arranged on the push block 200;

[0031] A limiting block 600 is disposed at the lower end of the lower buckle 300; the lower buckle 300 has an inner cavity 310; the surface of the inner cavity 310 is a conical surface; the limiting block 600 has a central hole 610; the central hole 610 is connected to the inner cavity 310;

[0032] The diameter of the central hole 610 matches the maximum diameter on the microneedle patch 500; the diameter of the lower end surface of the push block 200 is equal to or smaller than the maximum diameter on the microneedle patch 500; and a medical double-sided tape 400 is provided on the bottom surface of the limit block 600.

[0033] Specifically, the main function of the upper buckle 100 is to achieve uniform pressure on the microneedle patch; the main function of the lower buckle 300 is to achieve positioning of the drug delivery position, and to guide the upper buckle 100 to achieve precise drug delivery. In the lower buckle 100, the limit block 600 achieves precise positioning, and the inner cavity 310 achieves guidance.

[0034] Specifically, the microneedle patch 500 is attached to the lower surface of the push block 200; the push block 200 can be a magnetic block, and the microneedle patch 500 is a magnetic patch. Adhesive can also be provided on the lower surface of the push block 200 to achieve adsorption of the microneedle patch 500.

[0035] When using, first stick the microneedle patch 500 on the lower surface of the push block 200; stick the medical double-sided tape 400 on the bottom surface of the limit block 600; and tear off the remaining side of the medical double-sided tape 400 and stick it on the skin. So that the lower buckle 300 is fixed at the position where the drug needs to be administered. Then insert the upper buckle 100 into the inner cavity 310 of the lower buckle, press the pressing plate 110 so that the upper buckle 100 enters the lower buckle 300; then the microneedle patch 500 is squeezed out of the central hole 610 of the limit block 600, and the microneedle is delivered to the surface of the skin to puncture the skin; so as to achieve accurate and effective drug administration.

[0036] Specifically, the microneedle patch 500 includes a patch 510 and a support sheet 520; the patch 510 is provided with the support sheet 520; the support sheet 520 is provided with uniformly distributed microneedles 530; the diameter of the patch 510 is greater than the diameter of the support sheet 520. That is, the largest diameter on the microneedle patch 500 is the diameter of the patch 510. That is, the diameter of the central hole 610 matches the diameter of the patch 510; the diameter of the lower end surface of the push block 200 is equal to or less than the diameter of the patch 510.

[0037] The patch 510 uses double-sided tape with different adhesive forces on both sides; one side of the patch 510 is adhered to the push block 200, and the other side is adhered to the support sheet 520; when the microneedle patch is attached to the skin, the portion of the patch 510 extending out of the support sheet 520 is attached to the skin; and the adhesive force of the side attached to the skin is greater than the adhesive force of the patch 510 attached to the lower surface of the push block 200; thereby, after the microneedles pierce the skin, the microneedle drug delivery device can be easily separated from the skin, while ensuring that the microneedle patch 500 is attached to the skin, thereby achieving continuous drug delivery of the microneedles in the skin.

[0038] Embodiment 1

[0039] like Figures 1 to 4 As shown, a microneedle drug delivery device includes an upper buckle 100 and a lower buckle 300; the upper buckle 100 and the lower buckle 300 are both made by integral molding.

[0040] The upper buckle 100 and the lower buckle 300 are both made of polymer materials such as polystyrene, polyethylene, and polypropylene.

[0041] The upper buckle 100 includes a buckle body 120; a pressing plate 110 is disposed at the upper end of the buckle body 120; a push block 200 is disposed at the lower end; and a microneedle patch 500 is disposed on the push block 200;

[0042] A limiting block 600 is disposed at the lower end of the lower buckle 300; the lower buckle 300 has an inner cavity 310; the surface of the inner cavity 310 is a conical surface; the limiting block 600 has a central hole 610; the central hole 610 is connected to the inner cavity 310;

[0043] The diameter of the central hole 610 matches the maximum diameter of the microneedle patch 500; the diameter of the lower end surface of the push block 200 is equal to or smaller than the maximum diameter of the microneedle patch 500; the bottom surface of the limit block 600 is provided with a medical double-sided adhesive 400. The outer surface of the push block 200 is a conical surface that matches the inner cavity 310 of the lower buckle 300.

[0044] Specifically, the microneedle patch 500 includes a patch 510 and a support sheet 520; the patch 510 is provided with the support sheet 520; the support sheet 520 is provided with uniformly distributed microneedles 530; the diameter of the patch 510 is greater than the diameter of the support sheet 520; that is, the diameter of the central hole 610 matches the diameter of the patch 510; the diameter of the lower end surface of the push block 200 is equal to or less than the diameter of the patch 510. The patch 510 uses double-sided adhesive with different adhesive forces on both sides; one side of the patch 510 is attached to the push block 200, and the other side is attached to the support sheet 520; when the microneedle patch is attached to the skin, the part of the patch 510 extending out of the support sheet 520 is attached to the skin; and the adhesive force of the side attached to the skin is greater than the adhesive force of the patch 510 attached to the lower surface of the push block 200.

[0045] Embodiment 2

[0046] like Figures 5 to 8 As shown, a microneedle drug delivery device includes an upper buckle 100 and a lower buckle 300; the upper buckle 100 and the lower buckle 300 are combined; the upper buckle is made of a polymer material such as polystyrene, polyethylene, and polypropylene.

[0047] The upper buckle 100 includes a buckle body 120; a pressing plate 110 is disposed at the upper end of the buckle body 120; and a push block 200 is disposed at the lower end;

[0048] The push block 200 is detachably connected to the buckle body 120; a first connection boss 130 is disposed at the lower end of the buckle body 120; a first connection groove 210 matching the first connection boss 130 is disposed on the upper surface of the push block 200; and a microneedle patch 500 is disposed on the push block 200.

[0049] A limiting block 600 is provided at the lower end of the lower buckle 300; the limiting block 600 is detachably connected to the lower buckle 300; a second connecting boss 320 is provided on the lower surface of the lower buckle 300; and a second connecting groove 630 matching the second connecting boss 320 is provided on the upper surface of the limiting block 600.

[0050] By configuring the push block 200 to be detachably connected to the buckle body 120 and configuring the limit block 600 to be detachably connected to the lower buckle 300, it is possible to easily replace the push block 200 and the limit block 600 of different sizes, thereby facilitating the application of microneedle patches 500 of different sizes.

[0051] The lower buckle 300 has an inner cavity 310; the surface of the inner cavity 310 is a conical surface; the outer surface of the buckle body 120 is a conical surface matching the inner cavity 310 of the lower buckle 300. By setting the outer surface of the buckle body 120 as a conical surface matching the inner cavity 310 of the lower buckle 300, it is convenient to guide the upper buckle 100 during the pressing process.

[0052] The limiting block 600 has a central hole 610 ; the central hole 610 is connected to the inner cavity 310 ; the diameter of the central hole 610 matches the diameter of the microneedle patch 500 ; and a medical double-sided tape 400 is disposed on the bottom surface of the limiting block 600 .

[0053] The diameter of the lower end surface of the push block 200 is smaller than the maximum diameter of the microneedle patch 500; an anti-retraction boss 620 is provided in the central hole 610. The anti-retraction boss 620 can prevent the microneedle patch 500 from being lifted up when the upper buckle 100 is removed. Specifically, the microneedle patch 500 includes a patch 510 and a support sheet 520; the patch 510 is provided with a support sheet 520; the support sheet 520 is provided with uniformly distributed microneedles 530; the diameter of the patch 510 is larger than the diameter of the support sheet 520.

[0054] In order to ensure that the upper buckle 100 is smoothly pressed into the lower buckle 300, it is avoided that the upper buckle 100 is blocked by the anti-retraction boss 620 in the center hole 610 and cannot be pressed in. Further, the lower buckle 300 is made of medical elastic material. The specific elastic material can be rubber or silicone.

Claims

1. A microneedle drug delivery device, characterized in that: The invention comprises an upper buckle (100) and a lower buckle (300); the upper buckle (100) comprises a buckle body (120); a pressing plate (110) is arranged at the upper end of the buckle body (120); a pushing block (200) is arranged at the lower end; and a microneedle patch (500) is arranged on the pushing block (200); A limiting block (600) is provided at the lower end of the lower buckle (300); the lower buckle (300) has an inner cavity (310); the surface of the inner cavity (310) is a conical surface; the limiting block (600) has a center hole (610); the center hole (610) is in communication with the inner cavity (310); The diameter of the central hole (610) matches the maximum diameter on the microneedle patch (500); the diameter of the lower end surface of the push block (200) is equal to or smaller than the maximum diameter on the microneedle patch (500); and the bottom surface of the limit block (600) is provided with a medical double-sided adhesive tape (400).

2. A microneedle drug delivery device according to claim 1, characterized in that: The microneedle patch (500) comprises a patch (510) and a support sheet (520); the patch (510) is provided with a support sheet (520); the support sheet (520) is provided with uniformly distributed microneedles (530); the diameter of the patch (510) is greater than the diameter of the support sheet (520); and the patch (510) uses double-sided adhesive tape with different adhesive forces on both sides; one side of the patch (510) is adhered to the push block (200), and the other side is adhered to the support sheet (520); when the microneedle patch (500) is attached to the skin, the portion of the patch (510) extending out of the support sheet (520) is attached to the skin; and the adhesive force of the side attached to the skin is greater than the adhesive force of the patch (510) attached to the lower surface of the push block (200).

3. A microneedle drug delivery device according to claim 1, characterized in that: The diameter of the lower end surface of the push block (200) is smaller than the maximum diameter on the microneedle patch (500); and an anti-retraction boss (620) is arranged in the central hole (610).

4. A microneedle drug delivery device according to claim 2 or 3, characterized in that: The push block (200) is detachably connected to the buckle body (120); The lower end of the buckle body (120) is provided with a first connecting boss (130); the upper surface of the push block (200) is provided with a first connecting groove (210) matching the first connecting boss (130); The limiting block (600) is detachably connected to the lower buckle (300); a second connecting boss (320) is provided on the lower surface of the lower buckle (300); The upper surface of the limiting block (600) is provided with a second connecting groove (630) matching the second connecting boss (320).

5. A microneedle drug delivery device according to claim 2 or 3, characterized in that: The outer surface of the buckle body (120) or the push block (200) is a conical surface that matches the inner cavity (310) of the lower buckle (300).

6. A microneedle drug delivery device according to claim 2 or 3, characterized in that: The lower buckle (300) is made of medical elastic material.

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