Pesticide fertilizer granule containing cyantraniliprole and thiamethoxam

Abstract

The invention belongs to the technical field of pesticide fertilizer granules, and particularly relates to pesticide fertilizer granules containing cyantraniliprole and thiamethoxam. The invention relates to a pesticide-fertilizer granule which is prepared from the following components in percentage by mass: 0.1-0.5% of an insecticidal active component, 1-6% of a dispersing agent, 3-8% of a binder, 1-18% of a fertilizer active component, 0.1-0.75% of a synergist and the balance of inert filler, totaling 100%, wherein the insecticidal active component is prepared from cyantraniliprole and thiamethoxam; the synergist is farnesol. The medical fertilizer is composed of an insecticidal active component, a dispersant, a binder, a fertilizer active component, a synergist and an inert filler, and the fertilizer active component can provide nutrients for crop growth and promote crop growth; the synergist can enhance the control effect of the cyantraniliprole and thiamethoxam mixture on pests such as sugarcane two-point borer and the like.

Description

Technical Field

[0001] The invention belongs to the technical field of medicinal fertilizer granules, and particularly relates to medicinal fertilizer granules containing cyantraniliprole and thiamethoxam. Background Art

[0002] Cyantraniliprole, also known as cyantraniliprole, is a type of o-formylaminobenzamide insecticide that works by inhibiting nicotinic acid receptors, leading to uncontrolled release and consumption of calcium ions in insects, inhibiting muscle contraction, and ultimately paralyzing insect muscles until death. The biggest difference between cyanantraniliprole and chlorantraniliprole is that the structure of chlorantraniliprole is a chlorine group, while cyanantraniliprole replaces the chlorine group on the benzene ring structure with a cyanide group during structural optimization, making it more systemic, more insecticidal, and more broadly insecticidal, making it a diamide insecticide that can simultaneously control both chewing and piercing-sucking mouthparts pests.

[0003] Thiamethoxam is a second-generation nicotinoid insecticide, and its mechanism of action is: inhibiting the nicotinic acetylcholinesterase receptors in the insect central nervous system, thereby blocking the normal conduction of the insect central nervous system, causing paralysis and death of the pests. Thiamethoxam has contact, stomach poison and systemic activity, and can control coleoptera, diptera and lepidoptera pests, especially highly active against homoptera pests, and also has good control effects on piercing-sucking pests.

[0004] In the process of preventing and controlling crop pests, chemical agents play a pivotal role, with the advantages of easy application, quick effect and precise target. However, due to the high frequency and high concentration of chemical agents, crop pests have developed different degrees of resistance to different pesticides, resulting in the decreasing effect of pesticides on crop pests year by year, and there are also problems with the ecological environment and pesticide residues.

[0005] The information disclosed in this background technology section is only intended to enhance the understanding of the overall background of the invention and should not be regarded as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to a person skilled in the art. Summary of the invention

[0006] The object of the present invention is to provide a medicated fertilizer granule containing cyantraniliprole and thiamethoxam to solve the problems caused by the high frequency and high concentration use of chemical drugs.

[0007] To achieve the above object, the present invention provides the following technical solutions:

[0008] The first object of the present invention is to provide an insecticidal composition, which is composed of an insecticidal active ingredient and a synergist in a mass ratio of 1-3:9-1; wherein the insecticidal active ingredient is composed of cyantraniliprole and thiamethoxam in a mass ratio of 1:1-7, and the synergist is farnesol.

[0009] The second object of the present invention is to provide a medicinal fertilizer granule, which is prepared from the following ingredients, by mass percentage: 0.1-0.5% of insecticidal active ingredient, 1-6% of dispersant, 3-8% of binder, 1-18% of fertilizer active ingredient, 0.1-0.75% of synergist, and the inert filler is supplemented to 100%; wherein the insecticidal active ingredient is composed of cyantraniliprole and thiamethoxam; and the synergist is farnesol.

[0010] Preferably, the mass ratio of cyantraniliprole to thiamethoxam is 1:1-7.

[0011] Preferably, the dispersant is a mixture of sodium dodecyl sulfate and calcium lignin sulfonate in a mass ratio of 1:2.

[0012] Preferably, the binder is xanthan gum.

[0013] Preferably, the active ingredients of the fertilizer are mixed with urea, potassium chloride, zinc sulfate and potassium dihydrogen phosphate in a mass ratio of 4:1:1:3.

[0014] Preferably, the mass ratio of the insecticidal active ingredient to the synergist is 1-3:9-1.

[0015] Preferably, the inert filler is a mixture of attapulgite and diatomaceous earth in a mass ratio of 1:8.

[0016] Preferably, the medicated fertilizer granules are prepared from the following ingredients, measured by mass percentage: 0.02% cyantraniliprole, 0.1% thiamethoxam, 1.2% sodium lauryl sulfate, 2.4% calcium lignin sulfonate, 6% xanthan gum, 8% urea, 2% potassium chloride, 2% zinc sulfate, 6% potassium dihydrogen phosphate, 0.48% farnesol, and the inert filler is supplemented to 100%.

[0017] Compared with the prior art, the present invention has the following beneficial effects:

[0018] The medicated fertilizer of the present invention consists of an insecticide active ingredient, a dispersant, a binder, a fertilizer active ingredient, a synergist and an inert filler, wherein the fertilizer active ingredient can provide nutrients for the growth of crops and promote the growth of crops; the synergist can enhance the control effect of the mixture of cyantraniliprole and thiamethoxam on pests such as sugarcane borer, help reduce the amount of the agent used, and further alleviate the problem of pesticide residues; in addition, by screening suitable inert fillers, the heat storage stability of the active ingredients in the medicated fertilizer granules can be improved. DETAILED DESCRIPTION

[0019] The following is a clear and complete description of the technical solution of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by technicians in this field without creative work are within the scope of protection of the present invention.

[0020] 1. The synergistic effect of farnesol as a synergist

[0021] 1.1 Test pests

[0022] The sugarcane borer was collected from sugarcane planting areas, and was reared for several generations in the laboratory. The second-instar larvae were selected as the experimental subjects.

[0023] 1.2 Test agents

[0024] 94% cyantraniliprole TC, 98% thiamethoxam TC, 95% farnesol TC

[0025] 1.3 Test method (refer to "NY / T 1154.4-2006 Pesticide Indoor Bioassay Test Guidelines Insecticides Part 4: Systemic Activity Test Continuous Immersion Method")

[0026] The test agent was diluted with dimethyl sulfoxide solution and then with 0.1% Tween-80 aqueous solution to form a single-dose stock solution. Multiple groups of proportions were set up, and each single dose and proportioned mixture was diluted with 0.1% Tween-80 aqueous solution to form 5 mass concentration gradients.

[0027] Take out the sugarcane seedlings grown indoors with 4 true leaves with roots, clean the roots, absorb excess water with filter paper and dry them; insert the roots of the sugarcane seedlings into a conical flask (volume 50mL) containing 50mL of the drug solution. After 8 hours, take out the sugarcane seedlings, cut off the part of the stem that has not been in contact with the drug and put it in a culture dish with a diameter of 9cm, repeat 4 times for each mass of drug solution, and inoculate 20 test pests that have been starved for 4 hours for each repeat; and set the water treatment as a blank control. After 24 hours, investigate the death of the test insects, record the total number of insects and the number of dead insects in each treatment, and calculate the corrected mortality rate of each treatment.

[0028]

[0029] In the above formula: P--mortality rate, unit is %; K--number of dead insects; N--total number of insects treated.

[0030]

[0031] In the above formula: P1--corrected mortality rate, unit is %; P t --Treatment mortality rate, in %; P0--blank control mortality rate, in %.

[0032] 1.4 Data Analysis

[0033] The corrected mortality probability value and the logarithmic value of the pesticide concentration were subjected to regression analysis to calculate the LC value of each pesticide on the tested pests. 50 The co-toxicity coefficient (CTC value) of the mixture was calculated using the Sun Yunpei co-toxicity coefficient method, and the synergistic effect of the agent was evaluated based on the calculated co-toxicity coefficient (CTC value). The results are shown in Table 1.

[0034] Table 1 The synergistic effect of farnesol as a synergist in controlling sugarcane borer

[0035]

[0036] As shown in Table 1, when cyantraniliprole and thiamethoxam were mixed in a mass ratio of 1:1-7, their co-toxicity coefficients were all 120, showing a synergistic effect in killing sugarcane borer, indicating that mixing cyantraniliprole and thiamethoxam in a certain mass ratio can improve the control effect on sugarcane borer.

[0037] When cyantraniliprole or thiamethoxam was mixed with farnesol in a mass ratio of 1:1, the co-toxicity coefficients were 82.3550 and 60.1907, respectively, ranging from 80-120, showing an additive effect in killing the sugarcane stem borer.

[0038] When the mass ratio of cyantraniliprole and thiamethoxam to farnesol is within the range of 1-9:15-1, when the mass ratio of the mixture to farnesol is 1:15 or 9:1, the co-toxicity coefficient is between 80-120, showing an additive effect on killing sugarcane striped borer; when the mass ratio of the mixture to farnesol is 1-3:9-1, the co-toxicity coefficient is 120, showing a synergistic effect on killing sugarcane two-spotted borer. This shows that within the mass ratio range of 1-3:9-1, farnesol can be used as a synergist of the mixture of cyantraniliprole and thiamethoxam, enhancing the control effect of the mixture of cyantraniliprole and thiamethoxam on pests such as sugarcane two-spotted borer.

[0039] 2. Effects of different inert fillers on the stability of active ingredients in fertilizer granules

[0040] See Table 2 for the fertilizer granules.

[0041] Table 2 Formula of medicated fertilizer granules

[0042]

[0043] The insecticide active ingredient, dispersant, fertilizer active ingredient, synergist and inert filler in Table 2 are mixed evenly, a binder is added and kneaded, granulated, dried at 65° C. for 12 minutes, and sieved to obtain a finished product.

[0044] The finished product samples were sampled and tested with reference to the method of "2.3 Other preparations" in "GB / T 19136-2003 Determination of thermal storage stability of pesticides", specifically: 20g of the sample was placed in a glass bottle, spread into a smooth and even layer, and the bottle mouth was sealed and placed in a 54±2℃ constant temperature box for 14 days. Take it out and put it in a desiccator. After the finished product sample is cooled to room temperature, high-performance chromatography is used to separate and determine the mass fraction of insecticidal active ingredients in the sample within 24 hours. The results are shown in Table 3.

[0045] Table 3 Effects of different inert fillers on the stability of active ingredients in fertilizer granules

[0046]

[0047] As shown in Table 3, different inert fillers have different effects on the active ingredients cyantraniliprole and thiamethoxam in the fertilizer granules. Among them, kaolin and light calcium hydrochloride have a greater effect on the thermal storage stability of cyantraniliprole; white carbon black and bentonite have a greater effect on the thermal storage stability of thiamethoxam; while diatomaceous earth and attapulgite have a smaller effect on the thermal storage stability of cyantraniliprole and thiamethoxam.

[0048] 3. Effect of different inert filler ratios on the stability of active ingredients in fertilizer granules

[0049] See Table 4 for the granular formulations of fertilizers and pesticides.

[0050] Table 4 Formula of medicated fertilizer granules

[0051]

[0052] The finished product was made according to the above method and the mass fraction of insecticidal active ingredients in the finished product samples was determined. The results are shown in Table 5.

[0053] Table 5 Effect of different inert filler ratios on the stability of active ingredients in fertilizer granules

[0054]

[0055] As shown in Table 5, compared with single attapulgite or diatomite, the combination of attapulgite and diatomite in a certain mass ratio can effectively reduce the thermal storage decomposition rate of the active ingredients cyantraniliprole and thiamethoxam, and improve their thermal storage stability. In addition, the effects of different ratios of diatomite and attapulgite on the thermal storage stability of the active ingredients are significantly different. From a comprehensive comparison, when diatomite and attapulgite are mixed in a mass ratio of 1:8, the stability of the active ingredients of the fertilizer granules of the present invention is optimal.

[0056] 4. Field trials

[0057] Experimental site: Sugarcane planting fields in Guigang City, Guangxi Zhuang Autonomous Region.

[0058] Experimental design: random division of multiple plots, each plot has an area of ​​50m 2 , each treatment was repeated 4 times. The pesticide was applied during the soiling stage of sugarcane seedlings. When applying the pesticide, a small ditch was dug around the sugarcane planting hole, and the formula 3.2 fertilizer granules were spread in the small ditch and completely covered with soil. The blank control was set for the soiling treatment only. After 30 days of pesticide application, the total number of seedlings and dead seedlings in the plot were investigated and counted, and the dead heart rate and control effect were calculated. The results are shown in Table 6.

[0059]

[0060] Table 6 Field control effect of 0.12% cyantraniliprole·thiamethoxam fertilizer granules of the present invention on sugarcane borer

[0061]

[0062] It can be seen from Table 6 that the pesticide-fertilizer granules of the present invention can effectively prevent and control the sugarcane borer.

[0063] In summary, farnesol is added as a synergist in the fertilizer granules of the present invention, and farnesol can be used as a synergist of the mixture of cyantraniliprole and thiamethoxam, thereby enhancing the control effect of the mixture of cyantraniliprole and thiamethoxam on pests such as sugarcane borer. In addition, the inert filler composed of diatomaceous earth and attapulgite can improve the thermal storage stability of the active ingredients cyantraniliprole and thiamethoxam in the fertilizer granules.

[0064] The foregoing description of specific exemplary embodiments of the present invention is for the purpose of illustration and demonstration. These descriptions are not intended to limit the present invention to the precise form disclosed, and it is clear that many changes and variations can be made based on the above teachings. The purpose of selecting and describing the exemplary embodiments is to explain the specific principles of the present invention and its practical application, so that those skilled in the art can realize and utilize various different exemplary embodiments of the present invention and various different selections and changes. The scope of the present invention is intended to be limited by the claims and their equivalents.

Claims

1. A medicinal fertilizer granule, characterized in that: The medicated fertilizer granules are prepared from the following ingredients by mass percentage: 0.1-0.5% of insecticide active ingredient, 1-6% of dispersant, 3-8% of binder, 1-18% of fertilizer active ingredient, 0.1-0.75% of synergist, and the inert filler is supplemented to 100%; wherein the insecticide active ingredient is composed of cyantraniliprole and thiamethoxam; and the synergist is farnesol.

2. The medicinal fertilizer granules according to claim 1, characterized in that: The mass ratio of cyantraniliprole to thiamethoxam is 1:1-7.

3. The medicinal fertilizer granules according to claim 1, characterized in that: The dispersant is prepared by mixing sodium dodecyl sulfate and calcium lignin sulfonate in a mass ratio of 1:

2.

4. The medicinal fertilizer granules according to claim 1, characterized in that: The binder is xanthan gum.

5. The medicinal fertilizer granules according to claim 1, characterized in that: The active ingredients of the fertilizer are prepared by mixing urea, potassium chloride, zinc sulfate and potassium dihydrogen phosphate in a mass ratio of 4:1:1:

3.

6. The medicinal fertilizer granules according to claim 1, characterized in that: The mass ratio of the insecticidal active ingredient to the synergist is 1-3:9-1.

7. The medicinal fertilizer granules according to claim 1, characterized in that: The inert filler is prepared by mixing attapulgite and diatomaceous earth in a mass ratio of 1:

8.

8. The medicinal fertilizer granules according to claim 7, characterized in that: The medicated fertilizer granules are prepared from the following ingredients by mass percentage: 0.02% of cyantraniliprole, 0.1% of thiamethoxam, 1.2% of sodium lauryl sulfate, 2.4% of calcium lignin sulfonate, 6% of xanthan gum, 8% of urea, 2% of potassium chloride, 2% of zinc sulfate, 6% of potassium dihydrogen phosphate, 0.48% of farnesol, and the inert filler is supplemented to 100%.

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