Probiotic slow-release device for treating SFTS based on microcapsule technology
By using multiple concentric ring cylinders and limiting components in the probiotic microcapsule, the problems of uneven distribution of probiotics and gastric acid destruction are solved, and the uniform distribution and stable release of probiotics in the intestine are achieved, which improves the Treatment effect.
Patent Information
- Application Number
- CN202411508909.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-10-28
- Publication Date
- 2025-01-14
AI Technical Summary
Traditional probiotic microcapsules are unevenly distributed in the intestine, resulting in poor treatment effects. The existing technology is difficult to effectively protect probiotics from gastric acid damage, resulting in poor efficacy.
Multiple concentric ring cylinders are used to divide the probiotic powder layer by layer from the inside to the outside into independent intervals, and the stable connection between the capsule bottom shell and the ring cylinder is ensured through thin-walled settings and limiting components, thereby delaying probiotics. The diffusion of powder achieves uniform distribution.
Through the design of layered components and limiting components, the diffusion time of probiotic powder in the intestine is delayed, the probiotic powder is evenly distributed, the treatment effect is improved, and the premature spread of probiotics and poor efficacy is avoided. question.
Smart Images
Figure CN119302925A_ABST
Abstract
Description
Technical Field
[0001] The invention relates to the technical field of medical supplies, and in particular to a probiotic sustained-release device for SFTS treatment based on microcapsule technology. Background Art
[0002] Fever with thrombocytopenia syndrome (SFTS) is an acute infectious disease caused by a new type of Bunyavirus. The main clinical manifestations are fever, thrombocytopenia and gastrointestinal symptoms. A small number of patients have severe and rapidly progressing conditions and may die from multiple organ failure. Probiotics are a feasible method to regulate and improve intestinal microbiota. After being ingested by the human body, they colonize in the intestines and become symbiotic bacteria, establishing a mutually beneficial symbiotic relationship with the body and maintaining the balance of intestinal flora. Probiotics not only help to constitute an important part of intestinal local immunity, but also play an immunomodulatory role in other systems. Probiotics can help improve the gastrointestinal symptoms of SFTS patients by regulating the balance of intestinal flora, enhancing the intestinal mucosal barrier function, and reducing the risk of intestinal inflammation and infection. At the same time, the immunomodulatory effect of probiotics may also help to enhance the patient's overall immunity and fight viral infections. Probiotics are usually made into solids, which are dormant. When they are dissolved in warm water below 40 degrees, they will become active. Microencapsulation technology refers to encapsulating the target substance with an embedding material to form a microcapsule with a diameter of several micrometers to several millimeters and a semi-permeable or sealed capsule membrane. It can protect probiotics from the effects of high oxygen, acidity, low temperature and other environments, maintain the growth ability of cells and activate their metabolism in the intestine. It is considered to be one of the most effective probiotic embedding methods; Probiotics are used to regulate intestinal flora and mainly act on the intestines. When taking probiotics orally, the probiotics need to pass through the stomach first. Some probiotics will be killed by gastric acid, resulting in poor efficacy of the probiotics. Therefore, more probiotics need to be taken, resulting in waste of probiotics. The prior art provides a physical barrier for probiotics by using microcapsule walls made of enteric wall materials, which can effectively protect the probiotics from being destroyed by gastric acid, ensure that more live bacteria can reach the intestines, and play their probiotic effects. After the enteric microcapsule wall enters the intestine, the capsule shell gradually dissolves, and the probiotics in the capsule slowly precipitate and colonize in the intestine. However, in the middle stage of the dissolution of the capsule shell of the traditional sustained-release capsule, the capsule shell is basically completely damaged. At this time, the probiotics in the capsule spread rapidly, causing the probiotics to quickly colonize in a certain section of the intestine, resulting in a phenomenon that there are no probiotics in the tail of the intestine, making the distribution of probiotics in the intestine uneven, thereby affecting the balance of the intestinal flora and further affecting the treatment effect.
[0003] Therefore, a probiotic sustained-release device for SFTS treatment based on microcapsule technology was proposed. Summary of the invention
[0004] The purpose of the present invention is to provide a probiotic sustained-release device for SFTS treatment based on microcapsule technology, which divides the probiotic powder layer by layer from the inside to the outside into independent intervals through a plurality of concentrically arranged annular cylinders, and the capsule bottom shell and the bottom end of the annular cylinder are thin-walled, so that the capsule bottom shell and the bottom end of the annular cylinder are preferentially dissolved and cut off, so that the probiotic powder flows out from the bottom end of the capsule bottom shell during the dissolution of the capsule bottom shell, and cooperates with the layer-by-layer dissolution of the annular cylinder to delay the diffusion time of the probiotic powder in the intestine, thereby achieving the purpose of evenly distributing the probiotic powder in the intestine.
[0005] To achieve the above object, the present invention provides the following technical solutions: A probiotic sustained-release device for SFTS treatment based on microcapsule technology, comprising a capsule bottom shell, the top end of which is sleeved with a capsule upper shell, the capsule bottom shell and the capsule upper shell are both arranged in a hemispherical shape, the capsule bottom shell is filled with probiotic powder, the center of gravity of the capsule bottom shell and the capsule upper shell after being fitted together is located at the capsule bottom shell, a layered component is also arranged in the capsule bottom shell, the layered component comprises a plurality of annular cylinders uniformly arranged in the capsule bottom shell, the plurality of annular cylinders are concentrically and vertically arranged, the centers of the plurality of annular cylinders are located on the same straight line as the axis of the capsule bottom shell, a limiting component is arranged at the top end of the innermost annular cylinder, the layered component divides the probiotic powder into a plurality of annular independent spaces, the limiting component stably connects the innermost annular cylinder with the capsule upper shell and keeps the capsule upper shell and the capsule bottom shell in a fitted state.
[0006] Through the above scheme, the probiotic powder can be divided into independent intervals layer by layer from the inside to the outside through a plurality of concentrically arranged annular cylinders. In the process of dissolving the annular cylinders layer by layer, the probiotic powder in different intervals gradually diffuses, delaying the diffusion time of the probiotic powder in the intestine, thereby achieving the purpose of evenly distributing the probiotic powder in the intestine. The stability of the overall connection between the capsule bottom shell and the capsule upper shell can be guaranteed by the limiting component, avoiding the upper shell of the capsule from quickly separating from the capsule bottom shell during the dissolution process, preventing the probiotic powder from diffusing from the top of the capsule bottom shell, and ensuring the directional diffusion of the probiotic powder.
[0007] Preferably, the capsule bottom shell and the capsule upper shell are both made of enteric material, and a conical ring is fixedly installed on the bottom end of the capsule upper shell, a limiting groove is provided on the inner side of the conical ring, and the conical ring is sleeved on the top end of the capsule bottom shell, and a limiting ring matched with the limiting groove is fixedly installed on the top end of the capsule bottom shell, and the limiting groove and the limiting ring are both arranged in an arc shape.
[0008] Through the above scheme, the enteric material can effectively prevent the capsule bottom shell and the capsule upper shell from decomposing in the stomach, can prevent gastric acid from killing the probiotics, can ensure the survival rate of the probiotics, and the conical ring increases the thickness of the top of the capsule bottom shell, thereby slowing down the dissolution rate of the top of the capsule bottom shell, making it easier for the probiotic powder to flow out from the bottom of the capsule bottom shell in a directional manner during the dissolution of the capsule bottom shell.
[0009] Preferably, a sealing plate is provided at the bottom end of the capsule upper shell, and the bottom wall of the sealing plate is in contact with the top wall of the capsule bottom shell.
[0010] Through the above solution, the probiotic powder in the capsule bottom shell can be limited by the sealing plate, which can ensure that the center of gravity of the capsule bottom shell and the capsule upper shell after being attached is always located at the capsule bottom shell.
[0011] Preferably, the top wall of the annular tube is flush with the top wall of the capsule bottom shell, the inner wall thickness of the bottom end of the capsule bottom shell is smaller than the inner wall thickness of the top end of the capsule bottom shell, and the inner wall thickness of the bottom end of the annular tube is smaller than the inner wall thickness of the top end of the annular tube.
[0012] Through the above scheme, the capsule bottom shell and the bottom end of the annular tube are thin-walled. During the dissolution process, the capsule bottom shell and the bottom end of the annular tube are dissolved first, so that the probiotic powder first diffuses outward from the bottom end of the capsule bottom shell, and the probiotic powder at the top of the capsule bottom shell can gradually flow downward under the action of its own gravity, so that the probiotic powder is slowly released.
[0013] Preferably, the inner wall of the bottom end of the capsule bottom shell is arranged in a conical shape, and the bottom end of the capsule bottom shell is inclined downward from the inside to the outside.
[0014] Through the above solution, the inclined inner wall of the capsule bottom shell can facilitate the probiotic powder to flow to the outside of the capsule bottom shell.
[0015] Preferably, a cavity is opened in the capsule upper shell, and the cavity is filled with sterile air. The thickness of the outer wall of the capsule upper shell is the sum of the thickness of the outer wall of the capsule bottom shell and the thickness of the multiple annular cylinders.
[0016] Through the above scheme, when dissolving, the upper shell of the capsule has a larger thickness and a slower dissolution speed. At this time, the sterile air in the cavity can ensure that the upper shell of the capsule floats upward, and when the weight of the bottom shell of the capsule decreases due to the gradual diffusion of the probiotic powder, the bottom shell of the capsule is always at the bottom, ensuring that the annular tube dissolves layer by layer, which is conducive to the slow diffusion of the probiotic powder.
[0017] Preferably, the limiting assembly includes a limiting block, which is arranged in a ring shape, the bottom wall of the limiting block is connected to the top wall of the innermost annular cylinder, and the bottom end of the sealing plate is provided with a limiting groove adapted to the limiting block.
[0018] Through the above scheme, the ring-shaped limiting block enables the innermost circular tube to be completely embedded in the sealing plate, thereby increasing the contact area between the limiting block and the sealing plate, ensuring the stability of the connection between the capsule bottom shell and the capsule upper shell, and cooperating with the sealing plate to ensure the sealing of the probiotic powder in the independent space.
[0019] Preferably, the cross-sections of the limit block and the limit slot are both prismatic.
[0020] Through the above scheme, the setting of the prismatic surface increases the contact area between the limit block and the limit slot, thereby increasing the friction between the limit block and the limit slot, ensuring the stability of the sealing plate and the innermost circular cylinder, and further ensuring the sealing of the capsule bottom shell and the capsule upper shell.
[0021] Preferably, a pressing assembly is provided at the bottom end of the sealing plate, and the pressing assembly is used to press the probiotic powder toward the bottom end of the capsule bottom shell. The pressing assembly includes a plurality of pressing blocks, and the plurality of pressing blocks are connected to the bottom wall of the sealing plate, and the plurality of pressing blocks are arranged in the gap of the annular cylinder.
[0022] According to the above scheme, the probiotic powder in the bottom shell of the capsule can be squeezed against the thin wall of the annular tube by the pressing component, so that the probiotic powder can first slide out from the bottom end of the annular tube during the dissolution of the annular tube.
[0023] Preferably, the innermost pressing block is designed to be hemispherical, and the outer pressing blocks are all configured to be semicircular rings.
[0024] Through the above scheme, the semi-circular pressing block can easily press the probiotic powder in the gap between the outer ring cylinders, and the hemispherical pressing block can easily press the probiotic powder in the innermost ring cylinder, which can ensure the pressing effect.
[0025] Compared with the prior art, the present invention has the following beneficial effects: 1. By setting a layered component and a plurality of concentrically arranged annular cylinders, the probiotic powder is divided layer by layer from the inside to the outside into independent intervals, and the capsule bottom shell and the bottom end of the annular cylinder are thin-walled, so that the capsule bottom shell and the bottom end of the annular cylinder are preferentially dissolved and cut off, so that the probiotic powder flows out from the bottom end of the capsule bottom shell during the dissolution of the capsule bottom shell. In combination with the layer-by-layer dissolution of the annular cylinder, the diffusion time of the probiotic powder in the intestine is delayed, so that the probiotic powder is evenly distributed in the intestine.
[0026] 2. By setting a limit component, the limit block arranged in an annular shape enables the innermost annular cylinder to be completely embedded in the sealing plate, thereby ensuring the stability of the connection between the capsule bottom shell and the capsule upper shell, and cooperating with the sealing plate to ensure the sealing of the probiotic powder in the independent space. By embedding the limit block arranged on the innermost annular cylinder into the sealing plate, it can be ensured that the capsule upper shell is finally dissolved and separated from the capsule bottom shell, and that the probiotic powder is diffused only when the bottom wall of the capsule bottom shell and the bottom wall of the annular cylinder are gradually dissolved, thereby avoiding the probiotic powder from diffusing from the top of the capsule bottom shell, and ensuring the slow diffusion of the probiotic powder.
[0027] 3. By setting a pressing component, the probiotic powder in the capsule bottom shell is pressed by the pressing block at the bottom end of the sealing plate, so that the probiotic powder can be squeezed against the thin wall of the capsule bottom shell and the annular cylinder, and the thin wall of the capsule bottom shell and the annular cylinder can be in a compressed state. At the moment when the thin wall of the capsule bottom shell and the annular cylinder is dissolved, the probiotic powder at the bottom end of the capsule bottom shell can be diffused outward, which can prevent the probiotic powder from accumulating at the bottom end of the capsule bottom shell, and can facilitate the probiotic powder at the top end of the capsule bottom shell to continue to flow downward and diffuse, thereby ensuring the uniform colonization effect of the probiotic powder. BRIEF DESCRIPTION OF THE DRAWINGS
[0028] Figure 1 It is a schematic diagram of the overall structure of the present invention; Figure 2 for Figure 1 Schematic diagram of the cross-sectional structure of AA; Figure 3 It is a partial cross-sectional schematic diagram of the overall structure of the present invention; Figure 4 It is a structural schematic diagram of the capsule bottom shell of the present invention; Figure 5 for Figure 2 Enlarged view of middle B; Figure 6 It is a schematic diagram of the partial cross-sectional structure of the capsule bottom shell of the present invention; Figure 7 A bottom view of the upper shell of the capsule of the present invention; Figure 8 It is a schematic diagram of the partial cross-sectional structure of the upper shell of the capsule of the present invention.
[0029] In the figure: 1. Capsule bottom shell; 101. Limiting ring; 2. Capsule upper shell; 201. Conical ring; 2011. Limiting groove; 202. Cavity; 203. Sealing plate; 2031. Limiting slot; 3. Probiotic powder; 4. Layered component; 401. Ring cylinder; 5. Limiting component; 501. Limiting block; 6. Pressing component; 601. Pressing block. DETAILED DESCRIPTION
[0030] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.
[0031] See also Figures 1 to 8 The present invention provides a probiotic sustained-release device for SFTS treatment based on microcapsule technology, and the technical solution is as follows: A probiotic sustained-release device for SFTS treatment based on microcapsule technology comprises a capsule bottom shell 1, a capsule upper shell 2 is sleeved on the top of the capsule bottom shell 1, the capsule bottom shell 1 and the capsule upper shell 2 are both arranged in a hemispherical shape, the capsule bottom shell 1 is filled with probiotic powder 3, the center of gravity of the capsule bottom shell 1 and the capsule upper shell 2 after being fitted together is located at the capsule bottom shell 1, a layered component 4 is also arranged in the capsule bottom shell 1, the layered component 4 comprises a plurality of annular cylinders 401 uniformly arranged in the capsule bottom shell 1, the plurality of annular cylinders 401 are concentrically and vertically arranged, the centers of the plurality of annular cylinders 401 are located on the same straight line as the axis of the capsule bottom shell 1, a limiting component 5 is arranged on the top of the innermost annular cylinder 401, the layered component 4 divides the probiotic powder 3 into a plurality of annular independent spaces, the limiting component 5 stably connects the innermost annular cylinder 401 with the capsule upper shell 2 and keeps the capsule upper shell 2 and the capsule bottom shell 1 in a fitted state.
[0032] In the present embodiment, the vertically arranged annular cylinder 401 is open at the top, so it is convenient to add the probiotic powder 3 into the capsule bottom shell 1. Through a plurality of concentrically arranged annular cylinders 401, the probiotic powder 3 can be divided layer by layer from the inside to the outside into independent intervals. During the layer-by-layer dissolution of the annular cylinder 401, the probiotic powder 3 in different intervals gradually diffuses, delaying the diffusion time of the probiotic powder 3 in the intestine, so as to achieve the purpose of uniformly distributing the probiotic powder 3 in the intestine. Since the probiotic powder 3 is filled in the capsule bottom shell 1, the center of gravity of the capsule is located at the capsule bottom shell 1, so that the capsule can always keep the capsule bottom shell 1 at the bottom when it is delivered by water, and the probiotic powder 3 can be gradually diffused from the bottom end of the capsule bottom shell 1. Moreover, the stability of the overall connection between the capsule bottom shell 1 and the capsule upper shell 2 can be ensured by the limiting component 5, so as to avoid the capsule upper shell 2 from quickly separating from the capsule bottom shell 1 during the dissolution process, and the probiotic powder 3 can be prevented from diffusing from the top of the capsule bottom shell 1, so as to ensure the directional diffusion of the probiotic powder 3.
[0033] As an embodiment of the present invention, refer to Figure 2-Figure 4The capsule bottom shell 1 and the capsule upper shell 2 are both made of enteric material. A conical ring 201 is fixedly installed on the bottom end of the capsule upper shell 2. A limiting groove 2011 is provided on the inner side of the conical ring 201. The conical ring 201 is sleeved on the top of the capsule bottom shell 1. A limiting ring 101 matched with the limiting groove 2011 is fixedly installed on the top of the capsule bottom shell 1. The limiting groove 2011 and the limiting ring 101 are both arranged in an arc shape.
[0034] In this embodiment, the enteric material can effectively prevent the capsule bottom shell 1 and the capsule upper shell 2 from being decomposed in the stomach, can prevent gastric acid from killing the probiotics, and can ensure the survival rate of the probiotics. The conical ring 201 increases the thickness of the top of the capsule bottom shell 1, thereby slowing down the dissolution rate of the top of the capsule bottom shell 1, and facilitating the probiotic powder 3 to flow out from the bottom of the capsule bottom shell 1 in a directional manner during the dissolution of the capsule bottom shell 1. After the capsule upper shell 2 is fitted with the capsule bottom shell 1, the limiting ring 101 can be embedded in the limiting groove 2011, which can fix the outer sides of the capsule bottom shell 1 and the capsule upper shell 2 to each other, so that the capsule bottom shell 1 and the capsule upper shell 2 are stably connected.
[0035] As an embodiment of the present invention, refer to Figure 2 A sealing plate 203 is provided at the bottom end of the capsule upper shell 2, and the bottom wall of the sealing plate 203 is in contact with the top wall of the capsule bottom shell 1.
[0036] In this embodiment, the probiotic powder 3 in the capsule bottom shell 1 can be limited by the sealing plate 203, so that the probiotic powder 3 is always in the capsule bottom shell 1, which can prevent the probiotic powder 3 from flowing during the rolling of the pill, and ensure that the center of gravity of the capsule bottom shell 1 and the capsule upper shell 2 after being fitted together is always located at the capsule bottom shell 1.
[0037] As an embodiment of the present invention, refer to Figure 2 The top wall of the annular cylinder 401 is flush with the top wall of the capsule bottom shell 1 , the inner wall thickness of the bottom end of the capsule bottom shell 1 is smaller than the inner wall thickness of the top end of the capsule bottom shell 1 , and the inner wall thickness of the bottom ends of the multiple annular cylinders 401 is smaller than the inner wall thickness of the top end of the annular cylinder 401 .
[0038] In this embodiment, the bottom ends of the capsule bottom shell 1 and the annular tube 401 are thin-walled, so that during the dissolution process, the bottom ends of the capsule bottom shell 1 and the annular tube 401 are dissolved first, allowing the probiotic powder 3 to diffuse outward from the bottom end of the capsule bottom shell 1 first, and the probiotic powder 3 at the top end of the capsule bottom shell 1 can gradually flow downward under the action of its own gravity, so that the probiotic powder 3 is slowly released.
[0039] As an embodiment of the present invention, refer to Figure 2-Figure 3 The inner wall of the bottom end of the capsule bottom shell 1 is arranged in a conical shape, and the bottom end of the capsule bottom shell 1 is inclined downward from the inside to the outside.
[0040] In this embodiment, after the capsule bottom shell 1 and the bottom end of the annular cylinder 401 are gradually dissolved, the probiotic powder 3 can flow from the bottom end of the capsule bottom shell 1 to the outside, and the inclined inner wall of the capsule bottom shell 1 can facilitate the probiotic powder 3 to flow to the outside of the capsule bottom shell 1, thereby avoiding the probiotic powder 3 from piling up and ensuring that the probiotic powder 3 is evenly colonized in the intestine.
[0041] As an embodiment of the present invention, refer to Figure 2 A cavity 202 is provided in the capsule upper shell 2 , and the cavity 202 is filled with sterile air. The outer wall thickness of the capsule upper shell 2 is the sum of the outer wall thickness of the capsule bottom shell 1 and the thickness of the plurality of annular cylinders 401 .
[0042] In this embodiment, during dissolution, the capsule upper shell 2 has a large thickness and a slow dissolution speed. At this time, the sterile air in the cavity 202 can ensure that the capsule upper shell 2 floats upward, and can keep the capsule bottom shell 1 at the bottom when the probiotic powder 3 gradually diffuses and causes the weight of the capsule bottom shell 1 to decrease, thereby ensuring that the annular cylinder 401 dissolves layer by layer, which is beneficial to the slow diffusion of the probiotic powder 3. When a small amount of sterile air dissolves and diffuses in the intestine, the small amount of air will be gradually absorbed by the intestine and will not cause serious impact on the intestinal bacteria.
[0043] As an embodiment of the present invention, refer to Figure 5 The limiting assembly 5 includes a limiting block 501, which is arranged in an annular shape. The bottom wall of the limiting block 501 is connected to the top wall of the innermost annular cylinder 401, and the bottom end of the sealing plate 203 is provided with a limiting groove 2031 adapted to the limiting block 501.
[0044] In this embodiment, the limiting block 501 arranged in an annular shape allows the innermost annular cylinder 401 to be completely embedded in the sealing plate 203, thereby increasing the contact area between the limiting block 501 and the sealing plate 203, ensuring the stability of the connection between the capsule bottom shell 1 and the capsule upper shell 2, and cooperating with the sealing plate 203 to ensure the sealing of the probiotic powder 3 in the independent space, and can ensure that the capsule upper shell 2 is finally dissolved and separated from the capsule bottom shell 1, and can ensure that the probiotic powder 3 is diffused only when the bottom wall of the capsule bottom shell 1 and the bottom wall of the annular cylinder 401 are gradually dissolved.
[0045] As an embodiment of the present invention, refer to Figure 5 The cross-sections of the limiting block 501 and the limiting slot 2031 are both set to be prism-shaped.
[0046] In this embodiment, the surface of the limit block 501 with a prism-shaped cross section has a turning point, which can facilitate the limit block 501 to be stuck in the limit slot 2031, and the setting of the prism surface increases the contact area between the limit block 501 and the limit slot 2031, thereby increasing the friction between the limit block 501 and the limit slot 2031, and ensuring the stability of the sealing plate 203 and the innermost annular cylinder 401. As an embodiment of the present invention, refer to Figure 7-Figure 8 A pressing assembly 6 is provided at the bottom end of the sealing plate 203, and the pressing assembly 6 is used to press the probiotic powder 3 toward the bottom end of the capsule bottom shell 1. The pressing assembly 6 includes a plurality of pressing blocks 601, and the plurality of pressing blocks 601 are connected to the bottom wall of the sealing plate 203, and the plurality of pressing blocks 601 are arranged in the gap of the annular cylinder 401.
[0047] In this embodiment, by pressing the component 6, the probiotic powder 3 in the capsule bottom shell 1 can be squeezed against the thin walls of the capsule bottom shell 1 and the annular cylinder 401, so that the thin walls of the capsule bottom shell 1 and the annular cylinder 401 are in a compressed state, and at the moment when the thin walls of the capsule bottom shell 1 and the annular cylinder 401 are dissolved, the probiotic powder 3 at the bottom end of the capsule bottom shell 1 can diffuse outward, and the probiotic powder 3 at the top end of the capsule bottom shell 1 can continue to flow downward and diffuse.
[0048] As an embodiment of the present invention, refer to Figure 8 The innermost pressing block 601 is designed to be hemispherical, and the outer pressing blocks 601 are all designed to be semicircular.
[0049] In this embodiment, the semicircular pressing block 601 can press the probiotic powder 3 in the gap between the outer circular cylinders 401, and the hemispherical pressing block 601 can press the probiotic powder 3 in the innermost circular cylinder 401, and can press the probiotic powder 3 in the capsule bottom shell 1 in all directions, thereby ensuring the pressing effect.
[0050] Working principle: First, fill the capsule bottom shell 1 with probiotic powder 3. The vertically arranged annular cylinder 401 is open at the top, so it is convenient to add probiotic powder 3 into the capsule bottom shell 1. Through multiple concentrically arranged annular cylinders 401, the probiotic powder 3 can be divided layer by layer from the inside to the outside in independent intervals. After the filling is completed, the capsule upper shell 2 is sleeved on the capsule bottom shell 1. At this time, the limiting ring 101 can be embedded in the limiting groove 2011, so that the outer sides of the capsule bottom shell 1 and the capsule upper shell 2 can be fixed to each other, so that the capsule bottom shell 1 and the capsule upper shell 2 are stably connected; When the capsule upper shell 2 and the capsule bottom shell 1 are fitted together, the limiting block 501 arranged in an annular shape can be embedded in the limiting groove 2031, so that the innermost annular cylinder 401 is completely embedded in the sealing plate 203, thereby ensuring the stability of the connection between the capsule bottom shell 1 and the capsule upper shell 2, and cooperating with the sealing plate 203 to ensure the sealing of the probiotic powder 3 in the independent space, and ensuring that the capsule upper shell 2 is finally dissolved and separated from the capsule bottom shell 1, and the conical ring 201 increases the thickness of the top end of the capsule bottom shell 1, slowing down the dissolution speed of the top end of the capsule bottom shell 1, so as to facilitate the probiotic powder 3 to flow out from the bottom end of the capsule bottom shell 1 in a directional manner during the dissolution of the capsule bottom shell 1; When the sealing plate 203 contacts the capsule bottom shell 1, the pressing block 601 can make the probiotic powder 3 squeeze the capsule bottom shell 1 and the thin wall of the annular tube 401, so that the capsule bottom shell 1 and the thin wall of the annular tube 401 are in a compressed state; When taking the capsule, the enteric material can effectively prevent the capsule bottom shell 1 and the capsule upper shell 2 from being decomposed in the stomach, can prevent gastric acid from killing the probiotics, and can ensure the survival rate of the probiotics. When the capsule enters the intestine, the capsule begins to dissolve, and the bottom ends of the capsule bottom shell 1 and the annular tube 401 are thin-walled. The bottom ends of the capsule bottom shell 1 and the annular tube 401 are preferentially dissolved and cut off, and the probiotic powder 3 under the compressed state can flow outward from the bottom end of the capsule bottom shell 1, and the inclined inner wall of the capsule bottom shell 1 can facilitate the probiotic powder 3 to flow outward from the capsule bottom shell 1, which can prevent the probiotic powder 3 from piling up, and can ensure that the probiotic powder 3 is uniformly colonized in the intestine, and the probiotic powder 3 at the top of the capsule bottom shell 1 can gradually flow downward under the action of its own gravity, so that the probiotic powder 3 is slowly released; In the process of layer-by-layer dissolution of the annular cylinder 401, the probiotic powder 3 in different intervals gradually diffuses, delaying the diffusion time of the probiotic powder 3 in the intestine, so as to achieve the purpose of evenly distributing the probiotic powder 3 in the intestine. Since the probiotic powder 3 is filled in the capsule bottom shell 1, the center of gravity of the capsule is located at the capsule bottom shell 1, which can ensure that the capsule bottom shell 1 is always kept at the bottom when the capsule is delivered by water, and the probiotic powder 3 can be gradually diffused from the bottom end of the capsule bottom shell 1. The stability of the overall connection between the capsule bottom shell 1 and the capsule upper shell 2 can be ensured by the limiting component 5, so as to avoid the capsule upper shell 2 from quickly separating from the capsule bottom shell 1 during the dissolution process, and the probiotic powder 3 can be prevented from diffusing from the top of the capsule bottom shell 1, thereby ensuring the directional diffusion of the probiotic powder 3. During dissolution, the capsule upper shell 2 has a large thickness and a slow dissolution speed. At this time, the sterile air in the cavity 202 can ensure that the capsule upper shell 2 floats upward, and can keep the capsule bottom shell 1 at the bottom when the probiotic powder 3 gradually diffuses and causes the weight of the capsule bottom shell 1 to decrease, thereby ensuring that the annular cylinder 401 dissolves layer by layer, which is beneficial to the slow diffusion of the probiotic powder 3. When a small amount of sterile air dissolves and diffuses in the intestine, the small amount of air will be gradually absorbed by the intestine, and will not cause serious impact on the intestinal bacteria.
[0051] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.
Claims
1. A probiotic sustained-release device for SFTS treatment based on microcapsule technology, comprising a capsule bottom shell (1), the top end of which is provided with a capsule upper shell (2), characterized in that: The capsule bottom shell (1) and the capsule upper shell (2) are both arranged in a hemispherical shape. The capsule bottom shell (1) is filled with probiotic powder (3). The center of gravity of the capsule bottom shell (1) and the capsule upper shell (2) after being fitted together is located at the capsule bottom shell (1). A layered component (4) is also arranged in the capsule bottom shell (1). The layered component (4) comprises a plurality of annular cylinders (401) uniformly arranged in the capsule bottom shell (1). The plurality of annular cylinders (401) are concentrically and vertically arranged. The centers of the plurality of annular cylinders (401) and the axis of the capsule bottom shell (1) are located on the same straight line. A limiting component (5) is arranged at the top of the innermost annular cylinder (401). The layered component (4) divides the probiotic powder (3) into a plurality of annular independent spaces. The limiting component (5) enables the innermost annular cylinder (401) to be stably connected to the capsule upper shell (2) and enables the capsule upper shell (2) to maintain a fitted state with the capsule bottom shell (1).
2. The probiotic sustained-release device for SFTS treatment based on microcapsule technology according to claim 1, characterized in that: The capsule bottom shell (1) and the capsule upper shell (2) are both made of enteric material; a conical ring (201) is fixedly mounted on the bottom end of the capsule upper shell (2); a limiting groove (2011) is provided on the inner side of the conical ring (201); the conical ring (201) is sleeved on the top end of the capsule bottom shell (1); a limiting ring (101) matched with the limiting groove (2011) is fixedly mounted on the top end of the capsule bottom shell (1); the limiting groove (2011) and the limiting ring (101) are both arranged in an arc shape.
3. The probiotic sustained-release device for SFTS treatment based on microcapsule technology according to claim 1, characterized in that: A sealing plate (203) is provided at the bottom end of the capsule upper shell (2), and the bottom wall of the sealing plate (203) is in contact with the top wall of the capsule bottom shell (1).
4. The probiotic sustained-release device for SFTS treatment based on microcapsule technology according to claim 3, characterized in that: The top wall of the annular cylinder (401) is flush with the top wall of the capsule bottom shell (1); the inner wall thickness of the bottom end of the capsule bottom shell (1) is smaller than the inner wall thickness of the top end of the capsule bottom shell (1); and the inner wall thickness of the bottom end of the annular cylinder (401) is smaller than the inner wall thickness of the top end of the annular cylinder (401).
5. The probiotic sustained-release device for SFTS treatment based on microcapsule technology according to claim 4, characterized in that: The inner wall of the bottom end of the capsule bottom shell (1) is arranged in a conical shape, and the bottom end of the capsule bottom shell (1) is inclined downward from the inside to the outside.
6. The probiotic sustained-release device for SFTS treatment based on microcapsule technology according to claim 1, characterized in that: A cavity (202) is provided in the capsule upper shell (2), and the cavity (202) is filled with sterile air. The thickness of the outer wall of the capsule upper shell (2) is the sum of the thickness of the outer wall of the capsule bottom shell (1) and the thickness of the plurality of annular cylinders (401).
7. The probiotic sustained-release device for SFTS treatment based on microcapsule technology according to claim 3, characterized in that: The limiting assembly (5) comprises a limiting card block (501), the limiting card block (501) is arranged in an annular shape, the bottom wall of the limiting card block (501) is connected to the top wall of the innermost annular cylinder (401), and the bottom end of the sealing plate (203) is provided with a limiting card groove (2031) adapted to the limiting card block (501).
8. The probiotic sustained-release device for SFTS treatment based on microcapsule technology according to claim 7, characterized in that: The cross-sections of the limiting card block (501) and the limiting card slot (2031) are both arranged to be prismatic.
9. The probiotic sustained-release device for SFTS treatment based on microcapsule technology according to claim 3, characterized in that: A pressing assembly (6) is provided at the bottom end of the sealing plate (203), and the pressing assembly (6) is used to press the probiotic powder (3) toward the bottom end of the capsule bottom shell (1). The pressing assembly (6) comprises a plurality of pressing blocks (601), and the plurality of pressing blocks (601) are connected to the bottom wall of the sealing plate (203), and the plurality of pressing blocks (601) are arranged at the gap of the annular cylinder (401).
10. The probiotic sustained-release device for SFTS treatment based on microcapsule technology according to claim 9, characterized in that: The innermost pressing block (601) is designed to be hemispherical, and the outer pressing blocks (601) are all configured to be semicircular.