Bacteriostatic erection-assisting time-delay gel and preparation method thereof

Abstract

The invention discloses a bacteriostatic erection-assisting time-delay gel, and belongs to the field of external medicines. The gel is prepared from the following components: glycerol, 1, 2-propylene glycol, ethanol, polyethylene glycol distearate, potassium polysaccharide sulfate, 4-(butylamino)-benzoic acid 2-(dimethylamino) ethyl ester and sustained release elements containing traditional Chinese medicine extracts. Wherein the sustained-release element takes fibroin nano-microspheres as a carrier, carries traditional Chinese medicine extracts of fructus cnidii, saffron crocus and salvia miltiorrhiza, and enhances blood circulation and local metabolism through a sustained-release mechanism. The gel in the technology realizes multiple effects of reducing sensitivity, prolonging sexual life time and improving local blood circulation through matching of the components and a slow release technology.

Description

Technical Field

[0001] The invention belongs to the technical field of external medicines, and in particular relates to an antibacterial, erection-promoting and ejaculation-delaying gel and a preparation method thereof. Background Art

[0002] In recent years, Chinese herbal extracts based on natural plant ingredients have received extensive attention in the field of personal care and functional skin care products. Traditional Chinese medicine theory believes that Chinese herbal extracts have the potential to regulate body circulation, enhance local blood flow, and repair tissue function, which provides a natural and safe option for the development of functional products. For example, Cnidium monnieri extracts were used in ancient medicine to enhance male sexual function and have antibacterial and blood circulation-promoting effects; saffron is often used to promote local metabolism due to its anti-inflammatory, antioxidant and microcirculation-improving properties; and Danshen extracts are widely used in medicines and skin care products for their blood circulation and antioxidant properties. However, the poor stability and insufficient transdermal absorption of traditional Chinese herbal extracts limit their application in topical preparations. The development of modern technologies, such as nanocarriers and sustained-release mechanisms, provides new ways to solve these problems. By combining Chinese herbal extracts with carriers, such as silk protein nanospheres, not only can their bioavailability be improved, but also sustained and stable release of ingredients can be achieved. This technical solution is based on this concept, integrating Chinese herbal extracts such as Cnidium monnieri, Saffron, and Salvia miltiorrhiza into the delayed ejaculation and erection-aiding gel to optimize its functionality and user experience.

[0003] According to the related public technologies, the technical scheme with the publication number CN114191555A proposes a drug for treating erectile dysfunction, which repairs the damaged corpus cavernosum through YAP1 protein, thereby restoring erectile function. The publication number US20130095180A1 proposes an oral delayed-release pharmaceutical composition, which uses a specific sustained-release component to delay the release of drugs used for erectile function, so as to achieve long-term pharmacodynamic effects in the body. The technical scheme with the publication number JP2011012054A proposes a pharmaceutical composition containing a PDE5 inhibitor and AGKISTRODON BLOMHOFFII, which can enhance the erectile function of the penis through the above components.

[0004] The above technical solutions all propose drugs for improving penile erectile function. However, most of the above drugs are for oral administration, and their long-term side effects on the body still need to be investigated by continuous clinical data.

[0005] The foregoing discussion of the background art is intended only to facilitate an understanding of the present invention. This discussion does not acknowledge or admit that any of the material referred to is part of the common general knowledge. Summary of the invention

[0006] The purpose of the present invention is to provide an antibacterial, erectile and delayed ejaculation gel, which belongs to the field of external medicines. The components of the gel include glycerol, 1,2-propylene glycol, ethanol, polyethylene glycol distearate, polysaccharide sulfate potassium salt, 4-

[0007] (Butylamino)-benzoic acid 2-(dimethylamino)ethyl ester, and sustained-release agent containing Chinese herbal extracts. Among them, the sustained-release agent uses silk protein nano-microspheres as carriers, carrying Chinese herbal extracts of Cnidium monnieri, Saffron and Salvia miltiorrhiza, and enhances blood circulation and local metabolism through a sustained-release mechanism. The gel in this technology achieves multiple effects of reducing sensitivity, prolonging sexual intercourse time, and improving local blood circulation through the combination of various components and sustained-release technology.

[0008] The present invention adopts the following technical scheme: an antibacterial, erection-promoting and delayed-ejaculation gel, wherein the components in the gel are calculated by mass ratio and include: 22% to 25% glycerol; 6% to 7% 1,2-propylene glycol; 16% to 18% ethanol; 0.3% to 0.5% polyethylene glycol distearate; 0.2% to 0.4% potassium salt of polysaccharide sulfate; less than 0.1% 4-(butylamino)-benzoic acid 2-(dimethylamino)ethyl ester; 3% to 5% sustained-release agent; and the rest is pure water.

[0009] Preferably, the sustained-release agent includes a Chinese herbal medicine extract and silk protein, and the two are combined to form nano-microspheres; in the sustained-release agent, the silk protein accounts for 50% to 60% by mass.

[0010] Preferably, the Chinese herbal medicine extract includes Cnidium monnieri, Saffron and Salvia miltiorrhiza.

[0011] Preferably, the gel is in the form of a gel with a viscosity of 125,000 to 300,000 mPas.

[0012] Preferably, the gel further comprises a thickener or a gelling agent.

[0013] At the same time, a preparation method of an antibacterial, erection-promoting and ejaculation-delaying gel is proposed, and the preparation method is applied to prepare the gel; the preparation method comprises the following steps:

[0014] S100: Add propylene glycol and 1,2-propylene glycol to pure water and stir them with a vacuum homogenizer until they are completely dissolved; then add ethanol and stir again to obtain a basic solution;

[0015] S200: Dissolve the potassium sulfate of polysaccharide in an appropriate amount of water, keep the water temperature at 40°C, and use an ultrasonic disperser with stirring for 15 minutes to obtain a uniform potassium sulfate solution of polysaccharide; then add polyethylene glycol distearate and stir again to obtain Conditioning solution ;

[0016] S300: slowly dripping the conditioning solution into the base solution, and stirring the mixed solution of the two.

[0017] S400: slowly adding the sustained-release agent into the mixed solution obtained in step S300, and slowly stirring the solution at a speed of 200 rpm for more than 30 minutes during the adding process to obtain a mixed matrix.

[0018] S500: Dissolve 4-(butylamino)-benzoic acid 2-(dimethylamino)ethyl ester in a small amount of ethanol, slowly add it to the mixed matrix, continue to stir homogenously, and use a pH sensor to monitor the pH value of the current mixed matrix, slowly add sodium hydroxide solution to the mixed matrix, and adjust the pH value of the mixed matrix to 6.5-7.0.

[0019] S600: gradually adding a thickener to the mixed matrix, continuously stirring, and adjusting the viscosity of the mixed matrix so that the mixed matrix is ​​converted into a gel-like mixture; placing the mixture in a constant temperature oscillator and maintaining it at 25° C. for 12 hours or more to make the mixture fully uniform and form a stable gel.

[0020] S700: After degassing the gel using a centrifugal degassing device, it is aseptically filled into a clean container for storage.

[0021] Preferably, the preparation of the sustained-release agent includes synthesizing the Chinese herbal medicine extract with silk protein using microfluidic technology to obtain silk protein nanoparticles.

[0022] Preferably, when preparing the sustained-release agent, the flow rate ratio of the dispersed phase and the continuous phase in the microfluidic device is controlled, and the viscosity and surface tension of the liquid in the dispersed phase and the continuous phase are measured in real time to control the particle size of the obtained nano-microspheres.

[0023] The beneficial effects achieved by the present invention are:

[0024] 1. This technical solution combines the dual effects of Chinese herbal extracts and local anesthetics, which can effectively reduce sensitivity and prolong sexual intercourse time, and promote local blood circulation and enhance erectile effect through extracts of Cnidium monnieri, Saffron and Salvia miltiorrhiza. The blood circulation and anti-inflammatory properties of Chinese herbal ingredients complement the nerve signal blocking function of anesthetics, so that the product has the dual effects of delaying and helping erection, which is suitable for diverse user needs.

[0025] 2. Using silk protein nanospheres as a sustained-release carrier, Chinese medicine extracts can be stably encapsulated and continuously released on the skin surface. This technology significantly improves the stability and transdermal absorption efficiency of Chinese medicine active ingredients, and solves the problem of low absorption rate and short-lasting effect of traditional topical Chinese medicine preparations. At the same time, the sustained-release mechanism can reduce the irritation of active ingredients and improve user comfort and safety.

[0026] 3. The glycerol and 1,2-propylene glycol added to the gel provide moisturizing and lubricating functions, while the rapid volatilization of ethanol brings a cooling feeling and antibacterial effect, improving the comfort when applying. Polyethylene glycol distearate and polysaccharide potassium sulfate ensure the physical stability of the gel to prevent stratification or precipitation. The entire formula design focuses on user experience and safety, and all components are scientifically matched to avoid excessive irritation or skin discomfort. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] The present invention can be further understood from the following description in conjunction with the accompanying drawings. The components in the figures are not necessarily drawn to scale, but the emphasis is placed on illustrating the principles of the embodiments. In different views, the same reference numerals designate corresponding parts.

[0028] Figure 1 This is an infrared spectrum detection diagram of the gel described in the embodiment of the present invention;

[0029] Figure 2 This is a gas chromatography-mass spectrometry (GC-MS) test image of the gel described in the embodiment of the present invention;

[0030] Figure 3 This is a nuclear magnetic spectrum detection diagram of the gel described in the embodiment of the present invention;

[0031] Figure 4 This is a microcurrent sensitivity test diagram before and after applying the gel described in the embodiment of the present invention. DETAILED DESCRIPTION

[0032] In order to make the purpose, technical solutions and advantages of the present invention clearer, the present invention is further described in detail below in conjunction with its embodiments; it should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention. For those skilled in the art, after reviewing the following detailed description, other systems, methods and / or features of the present embodiment will become apparent. It is intended that all such additional systems, methods, features and advantages are included in this specification. Included within the scope of the present invention and protected by the appended claims. Additional features of the disclosed embodiments are described in the following detailed description, and these features will be apparent from the following detailed description.

[0033] The same or similar reference numerals in the drawings of the embodiments of the present invention correspond to the same or similar components; in the description of the present invention, it should be understood that if there are terms such as "upper", "lower", "left", "right" and the like indicating the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, it is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or component referred to must have a specific orientation. The invention is constructed and operated in a specific orientation, so the terms describing the positional relationship in the drawings are only used for exemplary description and cannot be understood as a limitation of this patent. For ordinary technicians in this field, the specific meanings of the above terms can be understood according to the specific circumstances.

[0034] Embodiment 1: Exemplarily, an antibacterial, erection-promoting and delayed ejaculation gel is proposed, in which the components in the gel, calculated by mass ratio, include: glycerol, 22% to 25%; 1,2-propylene glycol, 6% to 7%; ethanol, 16% to 18%; polyethylene glycol distearate, 0.3% to 0.5%; polysaccharide potassium sulfate, 0.2% to 0.4%; 4-(butylamino)-benzoic acid 2-(dimethylamino)ethyl ester, less than 0.1%; sustained-release agent, 3% to 5%; and the rest is purified water.

[0035] Preferably, the sustained-release agent includes a Chinese herbal medicine extract and silk protein, and the two are combined to form nano-microspheres; in the sustained-release agent, the silk protein accounts for 50% to 60% by mass.

[0036] Preferably, the Chinese herbal medicine extract includes Cnidium monnieri, Saffron and Salvia miltiorrhiza.

[0037] Preferably, the gel is in the form of a gel with a viscosity of 125,000 to 300,000 mPas.

[0038] Preferably, the gel further comprises a thickener or a gelling agent.

[0039] At the same time, a method for preparing an antibacterial, erection-promoting and ejaculation-delaying gel is proposed, and the method is used to prepare the gel; the method comprises the following steps:

[0040] Step S100, first add glycerol and 1,2-propylene glycol into pure water, and stir them with a vacuum homogenizer until they are completely dissolved; then add ethanol, and stir them again to obtain a basic solution. By using a vacuum homogenizer, bubbles can be effectively avoided from mixing in, and the uniformity of the solution can be improved.

[0041] Step S200, dissolving the potassium salt of polysaccharide sulfate in an appropriate amount of water, maintaining the water temperature at 40°C, and treating with an ultrasonic disperser and stirring for 15 minutes to obtain a uniform potassium salt of polysaccharide sulfate solution; then adding polyethylene glycol distearate and stirring again to obtain a tempered solution.

[0042] Step S300, slowly dripping the conditioning solution into the base solution, and stirring the mixed solution of the two.

[0043] Step S400, slowly adding the sustained-release agent to the mixed solution of step S300, stirring the solution slowly at 200 rpm for more than 30 minutes during the addition process to ensure that the microspheres are evenly dispersed, so as to obtain Mixed matrix .

[0044] Step S500, slowly adding 4-(butylamino)-benzoic acid 2-(dimethylamino)ethyl ester into ethanol.

[0045] Preferably, the preparation of the sustained-release agent includes synthesizing the Chinese herbal medicine extract with silk protein using microfluidic technology to obtain silk protein nanoparticles.

[0046] Preferably, when preparing the sustained-release agent, the flow rate ratio of the dispersed phase and the continuous phase in the microfluidic device is controlled, and the viscosity and surface tension of the liquid in the dispersed phase and the continuous phase are measured in real time to control the particle size of the obtained nano-microspheres.

[0047] Among them, glycerol, as a moisturizer, can form a protective film on the skin surface to prevent water evaporation and improve the softness of the gel and the lubricity when applied. 1,2-Propanediol, as a penetration enhancer, helps active ingredients penetrate the skin surface and improves the efficacy; at the same time, it provides appropriate viscosity, enhances the fluidity and uniformity of the gel, and assists active ingredients, such as the sustained-release agent and 4-(butylamino)-benzoic acid 2-(dimethylamino)ethyl ester, to effectively penetrate into the skin nerve endings and improve the effect of the drug. Ethanol provides a cooling effect of rapid evaporation, stimulating the local skin, increasing the cooling sensation in sensitive areas, and has an antibacterial effect to prevent the growth of microorganisms. Polyethylene glycol distearate and polysaccharide potassium sulfate can be used as emulsifiers and thickeners to help mix aqueous and oily components, ensure that the gel is uniform and stable, have certain anti-inflammatory and lubricating effects, and reduce skin irritation.

[0048] Among them, 2-(dimethylamino)ethyl 4-(butylamino)-benzoate acts as a local anesthetic to block the transmission of electrical signals at nerve endings, thereby reducing the sensitivity of the skin, reducing allergic reactions caused by sexual stimulation, and prolonging the duration of sexual life.

[0049] The sustained-release agent includes nano-microspheres made of Chinese herbal extracts (Cnidium monnieri, Saffron, Salvia miltiorrhiza) and silk protein, which can continuously release active ingredients through a sustained-release mechanism. Among them, Cnidium monnieri can effectively enhance local blood circulation; Saffron has anti-inflammatory and antioxidant effects and improves the skin microenvironment; Salvia miltiorrhiza can promote local metabolism and relieve irritation. Silk protein microspheres serve as carriers to enhance skin absorption and sustained release of active ingredients.

[0050] Embodiment 2: This embodiment should be understood to include at least all the features of any one of the aforementioned embodiments and to be further improved thereon.

[0051] In a preferred embodiment, the preparation of the sustained-release agent includes the following steps:

[0052] (1) Preparation of silk protein, comprising the following sub-steps:

[0053] E110: Raw material degumming treatment: silk was added into a sodium carbonate solution at a mass ratio of 1:8 to 0.05 mol / L sodium carbonate solution; the silk was boiled at 100°C for 30 minutes, and then rinsed with deionized water until neutral to obtain degummed silk.

[0054] E120: Dissolution treatment, dissolving the degummed silk in a ternary system of CaCl2:C2H5OH:H2O, wherein the molar ratio of CaCl2:C2H5OH:H2O is 1:2:8.

[0055] E130: Stir at 60° C. for 2 hours, filter at 3500 rpm and centrifuge for 15 minutes to obtain a silk protein solution.

[0056] E140: Place the silk protein solution in a cellulose dialysis bag and dialyze it in deionized water at 5°C for 5 days to remove impurities and small molecules.

[0057] E150: The dialyzed silk fibroin solution was freeze-dried at -25°C and a vacuum degree of 4Pa for 24 hours to obtain pure silk fibroin powder.

[0058] (2) Extracting Chinese medicinal materials, including the following sub-steps:

[0059] E210: Take flaky raw materials of Cnidium monnieri, Saffron and Salvia miltiorrhiza, grind them, and mix them in a mass ratio of 40:35:25.

[0060] E220: Add 10 times the amount of 50% ethanol aqueous solution to the mixed medicinal materials and reflux extract at 60°C for 2 hours;

[0061] E230: Collect the extract and concentrate under reduced pressure to a thick paste.

[0062] E240: The concentrated extract is spray dried, and the inlet temperature of the drying oven is set to 150°C and the outlet temperature is set to 80°C; the remaining material after drying is crushed to obtain the Chinese medicine extract powder.

[0063] (3) Preparation of nanoparticles, including the following sub-steps:

[0064] E310: Weigh the raw materials and weigh the following components according to the mass ratio: 2% to 3% silk fibroin, 2% to 3% Chinese herbal medicine extract, and 94% to 96% distilled water.

[0065] E320: Dissolve silk protein powder in distilled water, stir evenly, and prepare a silk protein solution with a concentration of 8 mg / mL.

[0066] E330: Dissolve the Chinese herbal medicine extract powder in the silk protein solution and stir until evenly dispersed to form a raw material liquid.

[0067] E340: The raw material liquid is mixed through a dispersed phase channel (wherein a Chinese medicine extract-silk fibroin solution is provided) and a continuous phase channel (wherein a buffer solution of 1.25 mol / L aminotrihydroxymethylmethane and HCl is provided) in a microfluidic device to form a nanoemulsion; the flow rate ratio Qd of the dispersed phase and the continuous phase is adjusted, preferably to 1:10 to 1:20, to control the particle size of the microspheres; and a dynamic light scattering instrument is used to monitor the particle size of the nano-microspheres in real time.

[0068] (4) Nano-processing, which includes the following sub-steps:

[0069] E410: Centrifuge the nanosphere suspension at 6000 rpm for 15 minutes, collect the precipitate, wash with distilled water and centrifuge twice to obtain purified nanospheres.

[0070] E420: Disperse the nanospheres in an appropriate amount of cryoprotectant solution and stir evenly; preferably, the cryoprotectant is a mixture of trehalose and mannitol in a mass ratio of 1:1; and freeze-dry at -25°C, vacuum degree 4Pa, for 24 hours to obtain the final sustained-release powder.

[0071] E430: Use dynamic light scattering to measure the particle size of the final powder to ensure that its average particle size is less than 200nm.

[0072] Finally, the powder was packaged in airtight containers and stored at room temperature.

[0073] Embodiment 3: This embodiment should be understood to include at least all the features of any of the above embodiments, and further improve upon them;

[0074] In a preferred embodiment, in step E340, the particle size D of the nanospheres is dynamically controlled using the following calculation formula:

[0075]

[0076] In the above formula, η disperse and η continuous are the solution viscosities of the dispersed phase and the continuous phase in the microfluidic channel preparation process, respectively.

[0077] Qd is the flow rate ratio of the dispersed phase to the continuous phase; γ is the interfacial surface tension between the dispersed phase liquid and the continuous phase liquid in the microchannel.

[0078] P / L refers to the pressure gradient in the microfluidic channel; higher shear stress can effectively stretch the dispersed phase droplets to produce smaller particle sizes; the channel geometry (such as nozzle size and length) and flow rate will affect the shear stress.

[0079] The adjustment parameters k, α1, and α2 are fitting variables and need to be determined by experiments. By analyzing the three variables, the weight of their influence on the particle size can be analyzed to optimize the above calculation formula.

[0080] By controlling the particle size of nano-microspheres through microfluidic technology, the bioavailability and efficiency of drugs can be significantly improved. Precise regulation of particle size can increase the specific surface area, making it easier for active ingredients to contact the skin and reach the target tissue through the skin barrier. For the Chinese herbal extracts (Cnidium monnieri, Saffron, Salvia miltiorrhiza) and local anesthetics (tetracaine) in this technical solution, the particle size is controlled within the range of 100-200nm, which can not only enhance the transdermal absorption capacity, but also ensure that the drug acts on specific targets, thereby improving the effect of delay and erection. At the same time, the uniform particle size distribution avoids the malabsorption phenomenon that may be caused by large particle size in traditional methods, making the product more efficient and reliable.

[0081] In addition, the particle size control of nano-microspheres also has the function of optimizing the sustained-release function. Microspheres prepared by microfluidic technology are highly uniform, and precise control of different release rates can be achieved through particle size adjustment. Smaller particle sizes ensure long-term release of active ingredients, while larger particle sizes can meet short-term effect requirements, so that the delayed-release gel can achieve sustained efficacy after use. This sustained-release mechanism not only prolongs the action time of the product, but also effectively reduces the initial release intensity of the active ingredients, reduces skin irritation, and improves safety of use and user experience.

[0082] Furthermore, experiments were conducted to test the effect of the erection-aiding and delaying gel of the present technical solution, and the effect was compared with that before the gel was used.

[0083] A total of 100 subjects were included in the experiment, all males, aged between 25 and 45 years old, with no history of major urogenital diseases.

[0084] Test environment: Conducted in a constant temperature (22°C) and interference-free laboratory. Use current stimulation equipment that meets medical standards. Use a transcutaneous electrical nerve stimulator (TENS) to apply a small current to the skin surface of the penis in an erect state. The current range is set from 1.5mA to 5.5mA, in steps of 0.5mA, and each stimulation lasts for 3 seconds.

[0085] The subjects first recorded their responses before applying the gel as a control group. After completing the control group test, the subjects applied the gel and waited 10 minutes to ensure that the gel was completely absorbed. The current sensitivity threshold after gel treatment was recorded.

[0086] In each test cycle, a gradually increasing microcurrent is applied to the subjects, and the lowest current value that the subjects first report feeling is recorded, that is, the current sensitivity threshold. The number of subjects who have an initial reaction at different current level thresholds is counted.

[0087] Attach Figure 4 As shown, in the control group, the thresholds of most subjects were concentrated at 2.0-3.0 mA, indicating high sensitivity. After using the gel, the thresholds shifted significantly to the right, and more subjects' sensitivity decreased to a higher current range.

[0088] Although the present invention has been described above with reference to various embodiments, it should be understood that many changes and modifications may be made without departing from the scope of the present invention. That is, the methods, systems and devices discussed above are examples. Various configurations may appropriately omit, replace or add various processes or components. For example, in alternative configurations, the method may be performed in an order different from the order described, and / or various components may be added, omitted and / or combined. Moreover, the features described with respect to certain configurations may be combined in various other configurations, such as different aspects and elements of the configurations may be combined in a similar manner. In addition, the elements therein may be updated as the technology develops, i.e., many elements are examples and do not limit the scope of the present disclosure or claims.

[0089] Specific details are given in the specification to provide a thorough understanding of the exemplary configurations including implementations. However, the configurations may be practiced without these specific details. For example, well-known circuits, processes, algorithms, structures, and techniques have been shown without unnecessary details to avoid obscuring the configurations. This description provides only example configurations and does not limit the scope, applicability, or configurations of the claims. On the contrary, the foregoing description of the configurations will provide those skilled in the art with an enabling description for implementing the described techniques. Various changes may be made to the functions and arrangements of the elements without departing from the spirit or scope of the present disclosure.

[0090] In summary, it is intended that the above detailed description is considered to be illustrative rather than restrictive, and it should be understood that the above embodiments should be understood to be only used to illustrate the present invention and not to limit the scope of protection of the present invention. After reading the contents of the present invention, the technician can make various changes or modifications to the present invention, and these equivalent changes and modifications also fall within the scope defined by the claims of the present invention.

Claims

1. An antibacterial, erection-promoting and ejaculation-delaying gel, characterized in that: The components in the gel are calculated by mass ratio and include: 22% to 25% propylene glycol; 6% to 7% 1,2-propylene glycol; 16% to 18% ethanol; 0.3% to 0.5% polyethylene glycol distearate; 0.2% to 0.4% polysaccharide sulfate potassium salt; less than 0.1% 4-(butylamino)-benzoic acid 2-(dimethylamino)ethyl ester; 3% to 5% sustained-release agent; and the rest is pure water.

2. The gel according to claim 1, characterized in that The sustained-release agent includes Chinese herbal medicine extract and silk protein, and the two are combined to form nano-microspheres; in the sustained-release agent, the silk protein accounts for 50% to 60% by weight.

3. The gel according to claim 2, characterized in that The Chinese medicinal extracts include Cnidium monnieri, Saffron and Salvia miltiorrhiza.

4. The gel according to claim 3, characterized in that The gel is in the form of a gel with a viscosity of 125,000 to 300,000 mPas.

5. The gel according to claim 4, characterized in that The gel also includes a thickening or gelling agent.

6. A method for preparing an antibacterial, erection-promoting and ejaculation-delaying gel, characterized in that: The preparation method is applied to prepare the gel as claimed in any one of claims 1 to 5; the preparation method comprises the following steps: S100: Add propylene glycol and 1,2-propylene glycol to pure water and stir them with a vacuum homogenizer until they are completely dissolved; then add ethanol and stir again to obtain a basic solution; S200: Dissolve the potassium sulfate of polysaccharide in an appropriate amount of water, keep the water temperature at 40°C, and use an ultrasonic disperser with stirring for 15 minutes to obtain a uniform potassium sulfate solution of polysaccharide; then add polyethylene glycol distearate and stir again to obtain Conditioning solution ; S300: slowly dripping the conditioning solution into the base solution, and stirring the mixed solution of the two. S400: slowly adding the sustained-release agent into the mixed solution obtained in step S300, and slowly stirring the solution at a speed of 200 rpm for more than 30 minutes during the adding process to obtain a mixed matrix. S500: Dissolve 4-(butylamino)-benzoic acid 2-(dimethylamino)ethyl ester in a small amount of ethanol, slowly add it to the mixed matrix, continue to stir homogenously, and use a pH sensor to monitor the pH value of the current mixed matrix, slowly add sodium hydroxide solution to the mixed matrix, and adjust the pH value of the mixed matrix to 6.5-7.

0. S600: gradually adding a thickener to the mixed matrix, continuously stirring, and adjusting the viscosity of the mixed matrix so that the mixed matrix is ​​converted into a gel-like mixture; placing the mixture in a constant temperature oscillator and maintaining it at 25° C. for 12 hours or more to make the mixture fully uniform and form a stable gel. S700: After degassing the gel using a centrifugal degassing device, it is aseptically filled into a clean container for storage.

7. The preparation method according to claim 6, characterized in that: The preparation of the sustained-release agent includes synthesizing the traditional Chinese medicine extract and silk protein by adopting microfluidic technology to obtain silk protein nano-microspheres.

8. The preparation method according to claim 7, characterized in that: When preparing the sustained-release agent, the flow rate ratio of the dispersed phase and the continuous phase in the microfluidic device is controlled, and the viscosity and surface tension of the liquid in the dispersed phase and the continuous phase are measured in real time to control the particle size of the obtained nano-microspheres.

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