Composition for relieving redness and relieving inflammatory chromophore as well as preparation method and application of composition

Abstract

The invention belongs to the technical field of cosmetics, and discloses a composition for relieving redness and inflammatory color deposition as well as a preparation method and application of the composition. The composition comprises the following components: a plant extract and a derivative thereof, zinc salt, a resorcinol derivative and protein, the plant extract and the derivative thereof comprise at least one of an artemisia apiacea extract and a derivative thereof, and a glycyrrhiza inflate extract. The artemisia apiacea extract and the derivative thereof and / or the glycyrrhiza inflate extract, the zinc salt, the resorcinol derivative and the protein are reasonably compounded, so that red, swollen and discomfort in the inflammation period can be relieved, repair of damaged skin can be promoted, color sink after inflammation can be reduced, and scar generation can be inhibited; meanwhile, the composition is mild and non-irritant, and is suitable for sensitive skin and damaged skin.

Description

Technical Field

[0001] The invention belongs to the technical field of cosmetics, and particularly relates to a composition for soothing and relieving redness and inflammatory pigmentation, as well as a preparation method and application thereof. Background Art

[0002] Damage to the skin barrier can cause dryness and itching of the skin, making it more sensitive to external stimuli, making the skin more prone to stress reactions, and causing discomfort such as redness, swelling, itching, pain, and heat. After acute or chronic inflammation of the skin, skin pigmentation often occurs, that is, post-inflammatory pigmentation. This condition usually has no racial or gender differences and is more likely to occur in people with darker skin. The depth and duration vary from person to person. Generally, inflammation and post-inflammatory pigmentation may last for several weeks, or even take 3 to 6 months to gradually subside, which seriously affects the appearance and psychological state of consumers.

[0003] Skin inflammation involves the action of multiple cells and inflammatory factors, and inflammatory pigmentation is first caused by the epidermal inflammatory response, which leads to increased secretion of arachidonic acid, which is oxidized into prostaglandins and lipid compounds, thereby activating the increased synthesis of melanosomes. When the inflammatory response destroys the basal layer of the epidermis, melanin particles are released into the papillary dermis and are engulfed by macrophages in the dermis, resulting in pigmentation; secondly, skin inflammation or trauma destroys the sulfhydryl groups of the skin, weakening its ability to bind copper ions, increasing the activity of tyrosinase, and leading to increased melanin synthesis; in addition, skin inflammation destroys the skin barrier, weakening its ability to resist adverse external stimuli, which can also lead to pigmentation.

[0004] At present, the products on the market often have single effects. Some products only consider relieving discomfort during inflammation by inhibiting inflammatory factors, but the inhibitory effect on melanin synthesis caused by increased tyrosinase activity is not obvious; some products use whitening ingredients to dilute the melanin that has already formed. The use of some conventional whitening ingredients such as VC ethyl ether can prevent melanin synthesis and reduce melanin precipitation, but consumers with damaged or sensitive skin have poor skin conditions, and conventional whitening ingredients are more irritating and may cause more serious skin problems. Summary of the invention

[0005] The present invention aims to solve at least one of the technical problems existing in the above-mentioned prior art. To this end, the present invention provides a composition for soothing and reducing redness and relieving inflammatory pigmentation, as well as a preparation method and application thereof. The composition can not only relieve the redness and swelling during inflammation and promote the repair of damaged skin, but also reduce pigmentation after inflammation and inhibit scar formation; at the same time, the composition of the present invention is mild and non-irritating, and is suitable for use on sensitive skin and damaged skin.

[0006] The first aspect of the present invention provides a composition comprising the following components: plant extracts and derivatives thereof, zinc salts, resorcinol derivatives and proteins; the plant extracts and derivatives thereof include at least one of Artemisia annua extracts and derivatives thereof and Glycyrrhiza inflata extracts.

[0007] In some embodiments of the present invention, the composition comprises the following components in parts by weight: 1 to 40 parts of plant extracts and derivatives thereof, 1 to 40 parts of zinc salts, 1 to 25 parts of resorcinol derivatives and 0.1 to 25 parts of protein.

[0008] In some embodiments of the present invention, the composition comprises the following components in parts by weight: 10 to 40 parts of plant extracts and derivatives thereof, 10 to 40 parts of zinc salts, 10 to 25 parts of resorcinol derivatives and 10 to 25 parts of proteins.

[0009] In some embodiments of the present invention, the Artemisia annua extract and its derivatives include at least one of artemisinin, Artemisia annua volatile oil, dihydroartemisinin, arglabin, and artesunate.

[0010] In some embodiments of the present invention, the Glycyrrhiza inflata extract includes at least one of licorice chalcone A, licorice chalcone B, licorice chalcone C, licorice chalcone D, and licorice chalcone E.

[0011] In some embodiments of the present invention, the zinc salt includes at least one of PCA zinc, hyaluronate zinc, gluconate zinc, and yeast / zinc fermentation products.

[0012] In some embodiments of the present invention, the resorcinol derivative includes at least one of 4-butylresorcinol, hexylresorcinol, and phenethylresorcinol.

[0013] In some embodiments of the present invention, the protein includes at least one of recombinant fibronectin, recombinant collagen, recombinant elastin, lactoferrin, and SOD (superoxide dismutase).

[0014] In some embodiments of the present invention, the recombinant collagen comprises recombinant type III collagen.

[0015] The second aspect of the present invention provides a method for preparing the composition according to the first aspect of the present invention, comprising the following steps:

[0016] The components are mixed to obtain a composition.

[0017] The third aspect of the present invention provides a cosmetic comprising the composition according to the first aspect of the present invention.

[0018] In some embodiments of the present invention, the content of the composition in the cosmetic is 0.1-10wt%, for example, it can be any point value among 0.1%, 0.5%, 2%, 4%, 6%, 8%, 10%, or a range value between two arbitrary point values.

[0019] In some embodiments of the present invention, the cosmetic further comprises cosmetically acceptable excipients.

[0020] In some embodiments of the present invention, the auxiliary material includes at least one of a humectant, a thickener, an emulsifier, an emollient, and a preservative.

[0021] In some embodiments of the present invention, the cosmetic comprises any one of essence, lotion, cream or mask.

[0022] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0023] In the composition of the present invention, the extract of Artemisia annua and its derivatives have bactericidal and anti-inflammatory, immunomodulatory, anti-angiogenic and anti-skin scar effects; the extract of Glycyrrhiza uralensis has multiple effects such as anti-inflammatory, analgesic, redness-reducing, acne-removing, and antibacterial; zinc is one of the essential trace elements for the human body, directly involved in the synthesis and metabolism of multiple enzymes, and zinc supplementation can control oil, anti-inflammatory, and accelerate wound healing; resorcinol derivatives are very effective skin whitening agents, which have a strong inhibitory effect on tyrosinase activity; proteins are involved in the regulation of various cells in the body, and biologically active proteins have the effects of anti-allergic soothing, acne-removing and anti-inflammatory, whitening and lightening spots, and promoting hair growth. The present invention rationally compounds the extract of Artemisia annua and its derivatives and / or the extract of Glycyrrhiza uralensis, zinc salts, resorcinol derivatives and proteins, which can not only relieve the redness and swelling discomfort during inflammation, promote the repair of damaged skin, but also fade the color after inflammation and inhibit scar formation.

[0024] The composition of the present invention is mild and non-irritating, and is suitable for use on sensitive skin and damaged skin. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Figure 1 This is a VISIA test comparison chart of Application Example 3 before use and 7 days after use;

[0026] Figure 2 This is a VISIA test comparison chart of Application Example 6 before use and 7 days after use. DETAILED DESCRIPTION

[0027] In order to make the technical scheme of the present invention more clearly understood by those skilled in the art, the following embodiments are listed for illustration. It should be pointed out that the following embodiments do not limit the protection scope of the present invention.

[0028] Unless otherwise specified, the raw materials, reagents or devices used in the present invention can be obtained from conventional commercial channels or by existing known methods.

[0029] Example 1

[0030] A composition comprising the following components in parts by weight: 25 parts of licorice chalcone A, 25 parts of zinc gluconate, 25 parts of hexylresorcinol and 25 parts of recombinant type III collagen;

[0031] The composition of this example can be prepared by mixing the various components.

[0032] Example 2

[0033] A composition comprising the following components in parts by weight: 40 parts of artemisinin, 20 parts of PCA zinc, 25 parts of 4-butylresorcinol and 15 parts of recombinant fibronectin;

[0034] The composition of this example can be prepared by mixing the various components.

[0035] Example 3

[0036] A composition comprising the following components in parts by weight: 40 parts of licorice chalcone B, 40 parts of zinc hyaluronate, 10 parts of phenethyl resorcinol and 10 parts of lactoferrin;

[0037] The composition of this example can be prepared by mixing the various components.

[0038] Example 4

[0039] A composition comprising the following components in parts by weight: 10 parts of Artemisia annua volatile oil, 40 parts of zinc gluconate, 25 parts of hexylresorcinol and 25 parts of recombinant type III collagen;

[0040] The composition of this example can be prepared by mixing the various components.

[0041] Example 5

[0042] A composition comprising the following components in parts by weight: 40 parts of dihydroartemisinin, 10 parts of PCA zinc, 25 parts of 4-butylresorcinol and 25 parts of recombinant elastin;

[0043] The composition of this example can be prepared by mixing the various components.

[0044] Example 6

[0045] A composition comprising the following components in parts by weight: 40 parts of licorice chalcone A, 40 parts of yeast / zinc fermentation product, 10 parts of phenethyl resorcinol and 10 parts of recombinant fibronectin;

[0046] The composition of this example can be prepared by mixing the various components.

[0047] Example 7

[0048] A composition comprising the following components in parts by weight: 12.5 parts of licorice chalcone A, 12.5 parts of artemisinin, 25 parts of zinc gluconate, 25 parts of hexylresorcinol and 25 parts of recombinant type III collagen;

[0049] The composition of this example can be prepared by mixing the various components.

[0050] Comparative Example 1

[0051] Compared with Example 1, the only difference is that licorice chalcone A is replaced by water.

[0052] Comparative Example 2

[0053] Compared with Example 1, the only difference is that zinc gluconate is replaced by water.

[0054] Comparative Example 3

[0055] Compared with Example 1, the only difference is that hexylresorcinol is replaced by water.

[0056] Comparative Example 4

[0057] Compared with Example 1, the only difference is that the recombinant type III collagen is replaced by water.

[0058] Comparative Example 5

[0059] Compared with Example 1, the only difference is that licorice chalcone A and zinc gluconate are replaced by water.

[0060] Comparative Example 6

[0061] Compared with Example 1, the only difference is that licorice chalcone A and hexylresorcinol are replaced by water.

[0062] Comparative Example 7

[0063] Compared with Example 1, the only difference is that licorice chalcone A and recombinant type III collagen are replaced by water.

[0064] Comparative Example 8

[0065] Compared with Example 1, the only difference is that zinc gluconate and hexylresorcinol are replaced by water.

[0066] Comparative Example 9

[0067] Compared with Example 1, the only difference is that zinc gluconate and recombinant type III collagen are replaced by water.

[0068] Comparative Example 10

[0069] Compared with Example 1, the only difference is that hexylresorcinol and recombinant type III collagen are replaced by water.

[0070] Comparative Example 11

[0071] Compared with Example 1, the only difference is that licorice chalcone A is replaced by glabridin.

[0072] Comparative Example 12

[0073] Compared with Example 1, the only difference is that zinc gluconate is replaced by allantoin.

[0074] Comparative Example 13

[0075] Compared with Example 1, the only difference is that hexylresorcinol is replaced by niacinamide.

[0076] Comparative Example 14

[0077] Compared with Example 1, the only difference is that the recombinant type III collagen is replaced by hydrolyzed collagen (derived from fish skin).

[0078] Application Example 1

[0079] A facial cream is composed of 99.5 wt % of a facial cream base and 0.5 wt % of the composition of Example 1. The formula of the facial cream base is shown in Table 1.

[0080] Table 1 Cream base formula

[0081]

[0082]

[0083] The preparation method of the facial cream of this example comprises the following steps:

[0084] 1) Add the phase A components into the water phase pot and stir at 80°C until completely dissolved;

[0085] 2) Add the phase B component into the oil phase pot, stir at 80°C until completely dissolved, slowly add the oil phase into the water phase for emulsification, homogenize at high speed for 15 minutes, and cool down;

[0086] 3) Cool the mixture to below 60° C., add the components of phase C and the composition of Example 1, and stir until the mixture is evenly dispersed.

[0087] Application Examples 2 to 7

[0088] Compared with Application Example 1, in Application Examples 2 to 7, the composition of Example 1 is replaced by the compositions of Examples 2 to 7, respectively, and other conditions are the same as those of Application Example 1.

[0089] Application Comparative Examples 1 to 14

[0090] Compared with Application Example 1, in Application Comparative Examples 1 to 14, the composition of Example 1 was replaced by the compositions of Comparative Examples 1 to 14, respectively, and other conditions were the same as those of Application Example 1.

[0091] Product performance testing

[0092] Experimental Example 1 Whitening Efficacy Test

[0093] 1.1 Experimental Principle

[0094] There are many factors that affect melanin synthesis. It is more appropriate and scientific to use the change of melanin content in melanocytes to judge the whitening effect of raw materials. At the same time, the synthesis of melanin is mainly regulated by tyrosinase, which is the rate-limiting enzyme for the initial reaction of melanin synthesis in the body. Therefore, this project compares the lightening effect of the combination on pigmentation by exploring the inhibition of melanin production and tyrosinase activity in vitro by single ingredients and combinations.

[0095] 1.2 Experimental methods

[0096] The melanin content after A375 cell lysis was detected by an ELISA instrument to evaluate the inhibitory effect of melanin production, and the tyrosinase activity inhibition effect was evaluated by the mushroom tyrosinase DOPA rate oxidation method, and the whitening effect of the raw materials was comprehensively evaluated.

[0097] Examples 1 to 7 and Comparative Examples 1 to 14 were tested, and the monomer components in Example 1 were used as a control reference. The concentrations of the monomers and the composition in the experiment were both 5 μM.

[0098] 1.3 Experimental Results

[0099] The results are shown in Table 2.

[0100] Table 2 Whitening effect comparison (unit: %)

[0101]

[0102]

[0103] The data in Table 2 above show that resorcinol derivatives, Glycyrrhiza inflata extract, Artemisia annua extract and its derivatives all have relatively significant whitening effects, while zinc salts and proteins have almost no whitening effects. The data of the comparative examples show that not only Glycyrrhiza inflata extract or Artemisia annua extract and its derivatives have good whitening synergistic effects with resorcinol derivatives, but zinc salts and proteins can also enhance the whitening effects of resorcinol derivatives and Glycyrrhiza inflata extract or Artemisia annua extract and its derivatives to a certain extent. The data of the embodiments show that the combination of Glycyrrhiza inflata extract and / or Artemisia annua extract and its derivatives with resorcinol derivatives, zinc salts and proteins has significant whitening effects.

[0104] Experimental Example 2 Anti-inflammatory Efficacy Test

[0105] 2.1 Experimental Principle

[0106] In the inflammatory site, NO is a highly active signaling molecule that plays an important role in regulating cell function. However, long-term, excessive NO can cause cell and tissue damage through cytotoxic effects, and then participate in the occurrence and development of certain inflammatory diseases. Therefore, inhibiting the excessive expression of NO has become an important indicator for the detection of efficacy substances that prevent inflammatory reactions and diseases.

[0107] 2.2 Experimental methods

[0108] The anti-inflammatory efficacy of cosmetic raw materials and finished products was evaluated by measuring the cytotoxicity of cosmetics on RAW264.7 mouse mononuclear macrophage leukemia cells and the inhibitory effect on the pro-inflammatory mediator NO released by them.

[0109] The compositions of Examples 1 to 7 and Comparative Examples 1 to 14 were tested, and the monomer components in Example 1 were used as references, 1 μg / mL LPS (lipopolysaccharide) was used as a control group, and the mass concentrations of the remaining monomers and compositions in the experiment were all 0.01%.

[0110] 2.3 Experimental Results

[0111] The results are shown in Table 3.

[0112] Table 3 NO content (unit: μM)

[0113]

[0114]

[0115] The data in Table 3 above show that protein, Glycyrrhiza inflata extract, Artemisia annua extract and its derivatives all have good anti-inflammatory effects, zinc salts also have certain anti-inflammatory effects, but resorcinol derivatives have no anti-inflammatory effects, and even have a slight pro-inflammatory effect. The data of the comparative examples show that zinc salts, proteins and Glycyrrhiza inflata extract or Artemisia annua extract and their derivatives have good anti-inflammatory synergistic effects, which can better enhance the anti-inflammatory effect. The data of the embodiments show that the composition of the present invention has a significant anti-inflammatory effect.

[0116] Experimental Example 3: Soothing and Removing Redness Test

[0117] 3.1 Experimental Principle

[0118] When sensitive skin is stimulated by physical, chemical, mental and other factors, the skin is prone to subjective symptoms such as burning, stinging, itching and tightness, with or without objective signs such as erythema, scaling, capillary dilation, etc. If it can relieve and improve skin irritation and other conditions, it can be considered to have a soothing effect.

[0119] 3.2 Experimental methods

[0120] 35 subjects with sensitive skin were selected and randomly tested on half of their face. The samples were used once every night. Under the conditions of temperature 20±2°C and humidity 50±10%, after the subjects' faces were cleaned for 20 minutes, lactic acid stinging test questionnaires were conducted on D7 (Day 7) and D14 (Day 14). Antera 3D was used to take photos on D7 and D28 (Day 28) to measure the average value of the facial redness area, and the soothing and redness-reducing effects of the creams of Application Examples 1 to 7 and the creams prepared based on the comparative examples with better in vitro anti-inflammatory data (Application Comparative Examples 3 and 13) on the skin were determined.

[0121] The lactic acid sting test questionnaire is scored on a 4-point scale, with 0 for no sensation, 1 for mild sensation, 2 for moderate sensation, and 3 for severe sensation. Intermediate scores can be used to describe the degree of sensation, such as 0.2, 0.5, 0.7 or other intermediate scores.

[0122] 3.3 Experimental Results

[0123] The results are shown in Tables 4 and 5.

[0124] Table 4 Mean values ​​of lactic acid stinging scores

[0125] Sample set D0 D7 D14 Application Example 1 3.6 2.7 1.9 Application Example 2 3.5 2.4 1.3 Application Example 3 3.8 2.2 1.0 Application Example 4 3.7 2.9 2.1 Application Example 5 3.6 2.6 1.8 Application Example 6 3.5 1.8 0.7 Application Example 7 3.6 2.8 2.0 Application Comparative Example 3 3.5 3.2 2.5 Application Comparative Example 13 3.6 3.0 2.7 Blank group (cream base) 3.7 3.5 3.0

[0126] The data in Table 4 above show that the extract of Glycyrrhiza inflata, the extract of Artemisia annua and its derivatives have a good effect on relieving short-term stinging pain, especially at D7, the relieving effect is obvious; while the protein has a more prominent effect on long-term (D14) soothing, which may be related to the fact that proteins promote epidermal barrier repair. The data of the application examples show that the composition of the present invention has a significant relieving effect, which is better than the comparative example and the blank example.

[0127] Table 5 Average values ​​of facial redness area

[0128]

[0129]

[0130] The data in Table 5 above show that the combination of Glycyrrhiza inflata extract or Artemisia annua extract and its derivatives with zinc salt has a better effect on redness reduction, especially at D7, the relief effect is obvious; and the effect of protein on long-term (D28) redness reduction is more prominent, which may be related to the fact that proteins promote epidermal barrier repair. The application example data show that the composition of the present invention has a significant redness reduction effect, which is better than the comparative example and the blank example.

[0131] Experimental Example 4: Acne Scar Reduction Test

[0132] 4.1 Experimental Principle

[0133] Although acne can be relieved by drugs or physical therapy, and the pustules and skin lesions can be relieved and subsided, even if the acne subsides, black and red acne marks, sunken acne pits or hyperplastic convex scars will still be left on the affected area. In order to investigate the effect of the composition of the present invention on the redness and swelling of acne and the reduction of acne marks, a clinical evaluation was conducted on consumers who are in the acne stage and have acne marks before and after using the product.

[0134] 4.2 Experimental methods

[0135] 30 subjects with sensitive skin with obvious acne and acne marks on their faces were selected and randomly divided into three groups. The subjects used the product once in the morning and evening. Before and 7 days after use, at a temperature of 20±2°C and a humidity of 50±10%, the subjects cleaned their faces and waited for 20 minutes. The efficacy of the composition of the present invention in anti-inflammatory acne removal and fading acne marks was comprehensively evaluated by questionnaire and taking photos with a VISIA instrument. The samples selected were application examples 1, 3, and 6 with better verification effects as described above.

[0136] 4.3 Experimental Results

[0137] The results of the questionnaire are shown in Tables 6, 7 and 8, where the effective rate is the sum of significant and very significant;

[0138] VISIA instrument test results are as follows Figure 1 and Figure 2 As shown, Figure 1 This is a comparison chart of the VISIA test of Application Example 3 before use (D0) and 7 days after use (D7). Figure 2 This is a comparison chart of the VISIA tests of Application Example 6 before use (D0) and 7 days after use (D7).

[0139] Table 6 Human efficacy analysis results of application example 1

[0140] Sample set Very subtle Not obvious obvious Very obvious Efficiency Acne and pimples are improved —— 30％ 20％ 50％ 70％ Improved skin irritation —— 10％ 60％ 30％ 90％ Skin redness improved —— 10％ 80％ 10％ 90％ Improved acne scar color —— 20％ 60％ 20％ 80％ Scars improved —— 30％ 60％ 10％ 70％

[0141] Table 7 Human efficacy analysis results of application example 3

[0142] Sample set Very subtle Not obvious obvious Very obvious Efficiency Acne and pimples are improved —— 20％ 70％ 10％ 80％ Improved skin irritation —— 10％ 40％ 50％ 90％ Skin redness improved —— 10％ 20％ 70％ 90％ Improved acne scar color —— —— 60％ 40％ 100％ Scars improved 10％ 50％ 40％ —— 40％

[0143] Table 8 Human efficacy analysis results of application example 6

[0144] Sample set Very subtle Not obvious obvious Very obvious Efficiency Acne and pimples are improved —— 10％ 60％ 30％ 90％ Improved skin irritation —— —— 30％ 70％ 100％ Skin redness improved —— —— 30％ 70％ 100％ Improved acne scar color —— 30％ 40％ 30％ 70％ Scars improved —— 50％ 50％ —— 50％

[0145] From the data in Tables 6 to 8 and Figure 1-2 It can be seen that, compared with before use on D7, the improvement of acne marks by application example 3 is the most significant, the improvement of acne in the red, swollen and inflamed state by application example 6 is the most significant, and the effect of fading acne and acne marks by application example 1 is good. The data of the application examples show that the composition of the present invention has a significant effect of soothing, reducing redness and fading pigmentation.

[0146] Based on the test results of the above experimental examples, it can be seen that the present invention rationally mixes Artemisia annua extract and its derivatives and / or Glycyrrhiza inflata extract, zinc salt, resorcinol derivatives and protein, which can not only relieve the redness and swelling during inflammation, promote the repair of damaged skin, but also reduce the color after inflammation and inhibit scar formation. At the same time, the composition of the present invention is mild and non-irritating, and is suitable for sensitive skin and damaged skin.

[0147] The preferred embodiments of the present invention are specifically described above, but the invention is not limited to the embodiments. Those skilled in the art may make various equivalent modifications or substitutions without violating the spirit of the invention. These equivalent modifications or substitutions are all included in the scope defined by the claims of this application.

Claims

1. A composition, characterized in that The composition comprises the following components: plant extracts and derivatives thereof, zinc salts, resorcinol derivatives and proteins; the plant extracts and derivatives thereof comprise at least one of Artemisia annua extracts and derivatives thereof and Glycyrrhiza inflata extracts.

2. The composition according to claim 1, characterized in that The composition comprises the following components in parts by weight: 1 to 40 parts of plant extracts and derivatives thereof, 1 to 40 parts of zinc salts, 1 to 25 parts of resorcinol derivatives and 0.1 to 25 parts of protein.

3. The composition according to claim 1, characterized in that The artemisia annua extract and its derivatives include at least one of artemisinin, artemisia annua volatile oil, dihydroartemisinin, arglabin and artesunate.

4. The composition according to claim 1, characterized in that The Glycyrrhiza inflata extract comprises at least one of licorice chalcone A, licorice chalcone B, licorice chalcone C, licorice chalcone D and licorice chalcone E.

5. The composition according to claim 1, characterized in that The zinc salt includes at least one of PCA zinc, hyaluronate zinc, gluconate zinc, and yeast / zinc fermentation products.

6. The composition according to claim 1, characterized in that The resorcinol derivative includes at least one of 4-butylresorcinol, hexylresorcinol and phenethylresorcinol.

7. The composition according to claim 1, characterized in that The protein includes at least one of recombinant fibronectin, recombinant collagen, recombinant elastin, lactoferrin and SOD.

8. The method for preparing the composition according to any one of claims 1 to 7, characterized in that: The following steps are involved: The components are mixed to obtain a composition.

9. A cosmetic, characterized in that: The cosmetic comprises the composition according to any one of claims 1 to 7.

10. The cosmetic according to claim 9, characterized in that: The content of the composition is 0.1-10 wt %.

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