Growth promoting patch for spleen and kidney deficiency type children and preparation method of growth promoting patch

Abstract

The invention relates to the technical field of Chinese herbal medicines, in particular to a spleen and kidney deficiency type child growth promoting patch and a preparation method thereof.The composition is composed of ligusticum wallichii, bighead atractylodes rhizome, pericarpium citri reticulatae, prepared rehmannia roots, fructus psoraleae and modified attapulgite natural products, has the effects of regulating the spleen and stomach function, tonifying the kidney and strengthening bones, is matched with specific acupuncture points, is beneficial to development of bones and muscles, and has a good effect on promoting growth of children. And the modified attapulgite has good uniformity and a slow release effect, so that the effective components in the rhizoma polygonati can gently and enduringly exert effects. The traditional Chinese medicine is scientific and reasonable in formula, an external treatment method is adopted, the effect is excellent, the effective rate is high, and pills prepared from the composition have the effects of stimulating the growth potential of children, increasing the growth speed of the children and improving the immunity of the children.

Description

Technical Field

[0001] The invention relates to the technical field of Chinese herbal medicines, in particular to a growth-promoting patch for children with spleen and kidney deficiency and a preparation method thereof. Background Art

[0002] With the rapid progress of society, the growth and development of children and future generations have received more and more attention. At present, Western medicine mainly relies on injections of growth hormone to promote the growth and height of children and adolescents, but the efficacy is limited and has no positive effect on diet, sleep and mood. It is expensive and has potential health risks. On the other hand, some people try to promote growth and development through food supplements, such as drinking milk, eating eggs and protein-rich meat. However, many children may be lactose intolerant or uninterested in foods such as eggs and milk. In the field of traditional Chinese medicine, although traditional Chinese medicine has a long history, the traditional Chinese medicine currently used to promote growth and development is mostly limited to prescription decoctions, and its efficacy has yet to be experimentally confirmed and clinically systematically verified. At the same time, the use of traditional Chinese medicine decoctions is not convenient enough, and children's compliance with medical treatment is also poor.

[0003] Traditional Chinese medicine believes that the kidney governs bones, stores essence, and produces marrow. The growth and development of bones mainly depends on the kidney, which is the innate foundation; the spleen and stomach are the acquired foundation, which transport and transform the essence of water and grain, are the basis of qi and blood production, and govern the muscles of the limbs. Only when the spleen and stomach function well in children can the kidney essence be sufficient. If the spleen and kidney functions are weak, calcium supplements and nutrients cannot be effectively absorbed and utilized. Children's growth and development is a matter of great concern to every parent. As a common factor affecting children's growth and development, spleen and kidney deficiency has always attracted much attention for its treatment and conditioning methods. In recent years, with the widespread application of traditional Chinese medicine in the field of pediatrics, patch therapy has gradually gained favor due to its advantages such as simple operation and few side effects.

[0004] Chinese patent CN202311427243.9 discloses a Chinese medicine compound for strengthening the spleen, benefiting the kidney and soothing the liver and a children's growth patch, which is composed of the following weights of Chinese medicine raw materials: 5-15g of Alpinia oxyphylla, 5-15g of Polygala tenuifolia, 1-5g of cinnamon bark; 5-15g of Poria cocos, 5-15g of Atractylodes macrocephala, 5-15g of Evodia rutaecarpa, 5-8g of salt fennel, 3-8g of cloves; 6-10g of Bupleurum chinense, 6-12g of stir-fried chicken gizzard lining; 5-8g of mint. The Chinese medicines in the Chinese medicine compound for strengthening the spleen, benefiting the kidney and soothing the liver can be ground into fine powder and mixed evenly, and then blended evenly with freshly squeezed ginger juice and made into a cake shape, and when used, it can be attached to the acupuncture points with medical dressings to make a Chinese medicine growth patch that promotes children's growth and development.

[0005] Slow growth and development in children is mostly due to spleen and kidney deficiency, that is, an imbalance between the innate and acquired foundations. Most of the current growth patches fail to select drugs and acupoints in a targeted manner according to the characteristics of spleen and kidney deficiency in children. The present invention mainly targets the common spleen and kidney deficiency type of slow growth in children, adopts traditional Chinese medicine that tonifies the spleen and kidney, and promotes blood circulation and qi, and cooperates with acupoints that tonify the spleen and kidney, which has very good targeting and better clinical efficacy. Summary of the invention

[0006] 1. Technical issues to be resolved

[0007] Based on the technical problems existing in the background technology, the present invention provides a growth-promoting patch for children with spleen and kidney deficiency. The patch is simple to operate and easy for children to cooperate with. It is a green therapy of pure Chinese medicine. Moreover, according to the characteristics of children's spleen and kidney deficiency, targeted spleen and kidney-tonifying Chinese medicine and acupoints are used for patch application, which gradually regulates the spleen and kidney functions, avoids the side effects caused by Western medicine growth hormone injection, and can also improve children's ability to resist diseases.

[0008] (II) Technical solution

[0009] In order to achieve the above-mentioned purpose, the present invention adopts the following technical scheme: a growth-promoting patch for children with spleen and kidney deficiency and a preparation method thereof, comprising the following components by weight: 6-10 parts of Chuanxiong, 5-8 parts of Atractylodes macrocephala, 5-8 parts of dried tangerine peel, 5-8 parts of Rehmannia root, 2-5 parts of Psoralea corylifolia, and 2-5 parts of modified attapulgite.

[0010] Chuanxiong: Chuanxiong has the effect of promoting blood circulation and promoting the flow of qi. Clinically, it can improve microcirculation, relieve fever, calm the nerves, regulate immunity and other pharmacological effects.

[0011] Atractylodes macrocephala: Atractylodes macrocephala has the effects of strengthening the spleen and replenishing qi, drying dampness and promoting diuresis. Clinically, it has multiple pharmacological effects such as promoting gastrointestinal motility, enhancing the body's immune function, and anti-oxidation.

[0012] Tangerine peel: Tangerine peel has the effect of regulating qi and strengthening the spleen. Clinically, it has multiple pharmacological effects such as regulating gastrointestinal motility, promoting gastric juice secretion, anti-oxidation, expectorant, antiasthmatic, antibacterial, and anti-tumor.

[0013] Rehmannia root: Rehmannia root has the effects of nourishing blood and yin, replenishing essence and filling marrow. Clinically, it has multiple pharmacological effects such as promoting hematopoiesis, enhancing memory, enhancing immunity, and lowering blood sugar.

[0014] Psoralea corylifolia: Psoralea corylifolia has the effects of warming the kidney and supporting yang, consolidating essence and reducing urine, promoting qi and relieving asthma, warming the spleen and stopping diarrhea. Clinically, it can regulate intestinal motility, enhance immunity, promote osteoblast proliferation, resist prostate hyperplasia, relieve asthma and other pharmacological effects.

[0015] Polygonatum: Polygonatum has the effects of replenishing qi and nourishing yin, strengthening the spleen, moistening the lungs, and benefiting the kidneys. Clinically, it has multiple pharmacological effects such as improving immunity, resisting fatigue, improving memory, and anti-oxidation.

[0016] The preparation method of modified attapulgite clay is as follows:

[0017] S11: Screening and removing minerals such as hydromica, quartz, opal and carbonate in the attapulgite clay to obtain paste-like attapulgite clay;

[0018] S12: Take paste-like attapulgite clay, and then take 10%-20% of polygonatum sibiricum powder by mass of attapulgite, mix the attapulgite and polygonatum sibiricum powder, add water and a dispersant, heat to 45-50° C., and perform ultrasonic dispersion at an ultrasonic frequency of 40-60 kHz for 5-10 min to obtain a paste;

[0019] S13: filtering the paste, washing it with ultrapure water for 3-5 times, and spray drying it to obtain a paste-like modified attapulgite;

[0020] S14: The paste-like modified attapulgite is input into an ultra-high-speed mixer for high-speed and strong stirring to obtain a natural gel-modified attapulgite with excellent thixotropy and adhesiveness.

[0021] Furthermore, in step S14, the high-speed strong stirring speed is controlled at 4000-11000 r / min, and the stirring time is 30-45 min.

[0022] Polygonatum sibiricum is a traditional Chinese medicinal material, which has the effects of delaying aging, improving cardiovascular function, resisting pathogenic microorganisms, stopping bleeding, lowering blood sugar, resisting viruses, anti-fatigue, anti-oxidation, improving body functions, etc. Attapulgite clay is a water-containing magnesium-rich nano-scale porous fibrous silicate clay mineral. The present invention uses Polygonatum sibiricum powder to modify the paste-like attapulgite clay, and when the attapulgite content in the attapulgite clay is ≥80%, its specific surface area is large, and various saponins, Polygonatum sibiricum polysaccharides, and various amino acids in the rhizome of Polygonatum sibiricum can be directly adsorbed into the pores, and can be grafted to the surface of attapulgite, thereby increasing its loading capacity for effective ingredients, thereby improving the uniformity of effective ingredients in the patch and the sustained release effect on the skin. The paste-like modified attapulgite obtained by the invention has the characteristics of ultrafine particles, low friction hardness, no sandy feeling, soft and delicate without peculiar smell, and the viscosity of the natural gel modified attapulgite obtained by high-speed and strong stirring is as high as 10000mPa·s, and its adsorption performance and moisture retention are further improved, so that the effective ingredients in the polygonatum can form a firm structure with the skin, and can stay on the skin for a long time, not only making the skin moist and not dry, but also making the effective ingredients better absorbed by the body; in addition, the modified attapulgite has good uniformity and sustained release effect, so that the effective ingredients in the polygonatum can gently and lastingly exert their effects.

[0023] The preparation method of the growth-promoting patch for children with spleen and kidney deficiency of the present invention specifically comprises the following steps:

[0024] S1: Mix chuanxiong, cinnamon bark, tangerine peel, evodia rutaecarpa, psoralea corylifolia and modified attapulgite, and grind into powder to obtain raw material powder of chuanxiong powder, atractylodes macrocephala powder, tangerine peel powder, rehmannia root powder, psoralea corylifolia powder and modified attapulgite;

[0025] S2: After mixing the raw material powders, add ginger juice and solid agent, blend evenly into a paste, and granulate to obtain a finished patch product.

[0026] Furthermore, the amount of solid agent added to every 100g of the medicinal powder is 70-80g, and the amount of ginger juice added is 80-120ml.

[0027] Furthermore, the ginger juice is obtained by washing, sorting, crushing and squeezing fresh ginger, and the temperature of the squeezer is controlled at 1 to 35°C.

[0028] The modified attapulgite clay in the present invention has good interfacial activity, and after being compounded with ingredients such as Chuanxiong, cinnamon, tangerine peel, and Evodia rutaecarpa, a synergistic effect can be produced, which helps to improve the growth-promoting effect of the finished patch, while further enhancing the stability and antibacterial performance of the finished patch; and, because the modified attapulgite clay has hydrophilic functional groups such as cations and hydroxyls, the finished patch of the present invention has good film-forming and spreading effects on the skin surface, thereby effectively improving product performance.

[0029] The method of using the children's growth-promoting patch preparation is as follows: place the children's growth-promoting patch pill in the central depression of the prepared acupoint patch, apply it to the acupoints such as Dazhui, Shenzhu, Pishu, Shenshu, Shenque, Mingmen, etc., leave it in for 2-4 hours, once a week, and 6-8 times as a course of treatment.

[0030] (III) Beneficial effects

[0031] The present invention provides a children's growth-promoting patch composition, which is composed of Chuanxiong, Atractylodes macrocephala, dried orange peel, Rehmannia glutinosa, Psoralea corylifolia and modified attapulgite natural products. The composition has the effects of regulating spleen and stomach function, tonifying kidney and strengthening bones, and cooperates with specific acupuncture points to benefit the development of bones and muscles, and has good growth-promoting function. The modified attapulgite clay has good uniformity and sustained release effect after being modified by polygonatum sibiricum powder, so that the effective ingredients in polygonatum sibiricum can be gently and lastingly exerted. The Chinese medicine formula of the present invention is scientific and reasonable, adopts external treatment, has excellent effect, and has high efficiency. The pills prepared by the composition have the effects of stimulating children's growth potential, improving children's growth rate, and improving children's immunity. DETAILED DESCRIPTION

[0032] The present invention is further described below in conjunction with the examples, but the present invention is not limited thereby. The experimental methods in the following examples are conventional methods unless otherwise specified.

[0033] Example 1

[0034] A growth-promoting patch for children with spleen and kidney deficiency and a preparation method thereof, comprising the following components by weight: 6 parts of chuanxiong, 5 parts of atractylodes macrocephala, 5 parts of dried orange peel, 5 parts of rehmannia root, 2 parts of psoralea corylifolia, and 2 parts of modified attapulgite.

[0035] The preparation process of modified attapulgite clay is as follows:

[0036] S11: Screening and removing minerals such as hydromica, quartz, opal and carbonate in the attapulgite clay to obtain paste-like attapulgite clay;

[0037] S12: Take a paste of attapulgite clay, and then take 10% of the mass of attapulgite, polygonatum sibiricum powder, mix the attapulgite and polygonatum sibiricum powder, add water and a dispersant, heat to 45° C., and perform ultrasonic dispersion at an ultrasonic frequency of 40 kHz for 5 minutes to obtain a paste;

[0038] S13: filtering the paste, washing it with ultrapure water for three times, and spray drying it to obtain a paste-like modified attapulgite;

[0039] S14: The paste-like modified attapulgite is input into an ultra-high-speed mixer for high-speed and strong stirring at a speed of 4000 r / min for 30 min to obtain a natural gel-modified attapulgite with excellent thixotropy and adhesiveness.

[0040] The preparation method of the growth-promoting patch for children with spleen and kidney deficiency of the present invention specifically comprises the following steps:

[0041] S1: Mix chuanxiong, cinnamon bark, tangerine peel, evodia rutaecarpa, psoralea corylifolia and modified attapulgite, and grind into powder to obtain raw material powder of chuanxiong powder, atractylodes macrocephala powder, tangerine peel powder, rehmannia root powder, psoralea corylifolia powder and modified attapulgite;

[0042] S2: After mixing the raw material powders, add ginger juice and solids, blend evenly into a paste, and granulate to obtain a finished patch product; the amount of solid added to every 100g of the powder is 70g, and the amount of ginger juice added is 80ml; the ginger juice is obtained by washing, sorting, crushing and squeezing fresh ginger, and the squeezer temperature is controlled at 1-35°C.

[0043] The method of using the children's growth-promoting patch preparation is as follows: place the children's growth-promoting patch pill in the central depression of the prepared acupoint patch, apply it to the acupoints such as Dazhui, Shenzhu, Pishu, Shenshu, Shenque, Mingmen, etc., leave it in for 2-4 hours, once a week, and 6-8 times as a course of treatment.

[0044] Example 2

[0045] A growth-promoting patch for children with spleen and kidney deficiency and a preparation method thereof, comprising the following components by weight: 10 parts of chuanxiong, 8 parts of atractylodes macrocephala, 8 parts of dried orange peel, 8 parts of rehmannia root, 5 parts of psoralea corylifolia, and 5 parts of modified attapulgite.

[0046] The preparation process of modified attapulgite clay is as follows:

[0047] S11: Screening and removing minerals such as hydromica, quartz, opal and carbonate in the attapulgite clay to obtain paste-like attapulgite clay;

[0048] S12: Take a paste of attapulgite clay, and then take 20% of the mass of attapulgite polygonatum powder, mix the attapulgite and polygonatum powder, add water and a dispersant, heat to 50° C., and perform ultrasonic dispersion at an ultrasonic frequency of 60 kHz for 10 minutes to obtain a paste;

[0049] S13: filtering the paste, washing it with ultrapure water for 5 times, and spray drying it to obtain a paste-like modified attapulgite;

[0050] S14: The paste-like modified attapulgite is fed into an ultra-high speed mixer for high-speed and strong stirring at a speed of 11000 r / min for 45 min to obtain a natural gel-modified attapulgite having excellent thixotropy and adhesiveness.

[0051] The preparation method of the growth-promoting patch for children with spleen and kidney deficiency of the present invention specifically comprises the following steps:

[0052] S1: Mix chuanxiong, cinnamon bark, tangerine peel, evodia rutaecarpa, psoralea corylifolia and modified attapulgite, and grind into powder to obtain raw material powder of chuanxiong powder, atractylodes macrocephala powder, tangerine peel powder, rehmannia root powder, psoralea corylifolia powder and modified attapulgite;

[0053] S2: After mixing the raw material powders, add ginger juice and solids, blend evenly into a paste, and granulate to obtain a finished patch product; the amount of solid added to every 100g of the powder is 80g, and the amount of ginger juice added is 120ml; the ginger juice is obtained by washing, sorting, crushing and squeezing fresh ginger, and the squeezer temperature is controlled at 1-35°C.

[0054] The method of using the children's growth-promoting patch preparation is as follows: place the children's growth-promoting patch pill in the central depression of the prepared acupoint patch, apply it to the acupoints such as Dazhui, Shenzhu, Pishu, Shenshu, Shenque, Mingmen, etc., leave it in for 2-4 hours, once a week, and 6-8 times as a course of treatment.

[0055] Example 3

[0056] A growth-promoting patch for children with spleen and kidney deficiency and a preparation method thereof, comprising the following components by weight: 8 parts of chuanxiong, 7 parts of atractylodes macrocephala, 7 parts of dried orange peel, 7 parts of rehmannia root, 4 parts of psoralea corylifolia, and 4 parts of modified attapulgite.

[0057] The preparation process of modified attapulgite clay is as follows:

[0058] S11: Screening and removing minerals such as hydromica, quartz, opal and carbonate in the attapulgite clay to obtain paste-like attapulgite clay;

[0059] S12: Take a paste of attapulgite clay, and then take 15% of the mass of attapulgite polygonatum powder, mix the attapulgite and polygonatum powder, add water and a dispersant, heat to 48° C., and perform ultrasonic dispersion at an ultrasonic frequency of 50 kHz for 8 minutes to obtain a paste;

[0060] S13: filtering the paste, washing it with ultrapure water for 4 times, and spray drying it to obtain a paste-like modified attapulgite;

[0061] S14: The paste-like modified attapulgite is input into an ultra-high-speed mixer for high-speed and strong stirring at a speed of 8000 r / min for 38 min to obtain a natural gel-modified attapulgite with excellent thixotropy and adhesiveness.

[0062] The preparation method of the growth-promoting patch for children with spleen and kidney deficiency of the present invention specifically comprises the following steps:

[0063] S1: Mix chuanxiong, cinnamon bark, tangerine peel, evodia rutaecarpa, psoralea corylifolia and modified attapulgite, and grind into powder to obtain raw material powder of chuanxiong powder, atractylodes macrocephala powder, tangerine peel powder, rehmannia root powder, psoralea corylifolia powder and modified attapulgite;

[0064] S2: After mixing the raw material powders, add ginger juice and solids, blend evenly into a paste, and granulate to obtain a finished patch product; the amount of solid added to every 100g of the powder is 75g, and the amount of ginger juice added is 100ml; the ginger juice is obtained by washing, sorting, crushing and squeezing fresh ginger, and the squeezer temperature is controlled at 1-35°C.

[0065] The method of using the children's growth-promoting patch preparation is as follows: place the children's growth-promoting patch pill in the central depression of the prepared acupoint patch, apply it to the acupoints such as Dazhui, Shenzhu, Pishu, Shenshu, Shenque, Mingmen, etc., leave it in for 2-4 hours, once a week, and 6-8 times as a course of treatment.

[0066] Typical Cases

[0067] Case 1:

[0068] Jiang, girl, born on May 9, 2019, measured height 101cm in March 2023 (median: 103.1cm), weight: 15kg, normal range of bone age. Usually weak and prone to colds, sweating. Father's height: 168cm, mother's height: 160cm. Treatment of children with spleen and kidney deficiency with growth-promoting patch prepared in Example 3 of the present invention (once a week for 7 consecutive times from March to May 2023). Height measured in March 2024: 113cm (median: 110.2cm), weight 18kg, sweating stopped, physical condition improved significantly, and the number of colds decreased significantly.

[0069] Case 2:

[0070] Huang, boy, born on November 11, 2015, measured height 113cm (median: 124.0cm) in May 2023, weight: 19kg, bone age normal range. Usually has partiality and hyperhidrosis. Father's height: 160cm, mother's height: 155cm. The growth-promoting patch for children with spleen and kidney deficiency prepared by the present invention (once a week for 7 consecutive times between May and July 2023). Height measured in May 2024: 126cm (median: 130.0cm), weight 22.5kg, hyperhidrosis stopped, and food smells good.

[0071] Case 3:

[0072] Hu, a boy, was born on October 22, 2012. Height was 136cm (median: 143.3cm) and weight was 21kg in May 2023. He was in the normal range of bone age. He usually has a partial diet and goes to bed late, after 11pm. Father's height: 170cm, mother's height: 160cm. The growth-promoting patch for children with spleen and kidney deficiency prepared by the present invention was used for treatment (once a week for 7 consecutive times between May and July 2023). Height was 145cm (median: 149.7cm) and weight was 23kg in May 2024. He had a good appetite.

[0073] The above contents are merely examples and explanations of the concept of the present invention. Those skilled in the art may make various modifications or additions to the specific embodiments described or replace them in a similar manner. As long as they do not deviate from the concept of the invention or exceed the scope defined by the claims, they shall all fall within the protection scope of the present invention.

Claims

1. A growth-promoting patch for children with spleen and kidney deficiency, characterized in that: The invention comprises the following components in parts by weight: 6-10 parts of chuanxiong, 5-8 parts of atractylodes macrocephala, 5-8 parts of dried orange peel, 5-8 parts of prepared rehmannia root, 2-5 parts of psoralea corylifolia and 2-5 parts of modified attapulgite.

2. A growth-promoting patch for children with spleen and kidney deficiency according to claim 1, characterized in that: The modified attapulgite clay preparation method is as follows: S11: Screening and removing minerals such as hydromica, quartz, opal and carbonate in the attapulgite clay to obtain paste-like attapulgite clay; S12: Take paste-like attapulgite clay, and then take 10%-20% of polygonatum sibiricum powder by mass of attapulgite, mix the attapulgite and polygonatum sibiricum powder, add water and a dispersant, heat to 45-50° C., and perform ultrasonic dispersion at an ultrasonic frequency of 40-60 kHz for 5-10 min to obtain a paste; S13: filtering the paste, washing it with ultrapure water for 3-5 times, and spray drying it to obtain a paste-like modified attapulgite; S14: The paste-like modified attapulgite is input into an ultra-high-speed mixer for high-speed and strong stirring to obtain a natural gel-modified attapulgite with excellent thixotropy and adhesiveness.

3. A growth-promoting patch for children with spleen and kidney deficiency according to claim 2, characterized in that: In step S14, the high-speed strong stirring speed is controlled at 4000-11000 r / min, and the stirring time is 30-45 min.

4. A preparation method for a growth-promoting patch for children with spleen and kidney deficiency as claimed in any one of claims 1 to 3, characterized in that: The following steps are involved: S1: Mix chuanxiong, cinnamon bark, tangerine peel, evodia rutaecarpa, psoralea corylifolia and modified attapulgite, and grind into powder to obtain raw material powder of chuanxiong powder, atractylodes macrocephala powder, tangerine peel powder, rehmannia root powder, psoralea corylifolia powder and modified attapulgite; S2: After mixing the raw material powders, add ginger juice and solid agent, blend evenly into a paste, and granulate to obtain a finished patch product.

5. A growth-promoting patch for children with spleen and kidney deficiency according to claim 4, characterized in that: In the step S2, the amount of solid agent added to every 100g of the medicinal powder is 70-80g, and the amount of ginger juice added is 80-120ml.

6. A growth-promoting patch for children with spleen and kidney deficiency according to claim 4, characterized in that: The ginger juice in step S2 is obtained by washing, sorting, crushing and squeezing fresh ginger, and the temperature of the squeezer is controlled at 1-35°C.