Intelligent residual amount monitoring system and monitoring method for liquid chromatograph

Abstract

The invention belongs to the technical field of solvent monitoring, and particularly relates to an intelligent remaining amount monitoring system and method for a liquid chromatograph, the system comprises a control system and a liquid chromatograph main body, the control system is connected with an alarm, a tray assembly is arranged at the top end of the liquid chromatograph main body, and the tray assembly comprises a tray base and a solvent bottle tray; a placing groove is formed in the top end of the solvent bottle disc, a solvent bottle is arranged in the placing groove, a weighing disc is arranged at the bottom of the solvent bottle disc, and a weighing module is arranged at the bottom of the weighing disc and comprises a weighing main board and a weighing sensor; through the integrated control system, the weighing module and the alarm, real-time monitoring and intelligent control of the residual solvent amount are achieved, the actual volume amount of the solvent is calculated through the mass-volume conversion formula by means of mass data collected in real time, automatic alarm can be achieved when the residual solvent amount is lower than the preset alarm volume amount, and the alarm efficiency is improved. Damage caused by operation of the system under the liquid-free working condition is avoided, and the use safety is improved.

Description

Technical Field

[0001] The invention belongs to the technical field of solvent monitoring, and in particular relates to an intelligent residual monitoring system and a monitoring method for a liquid chromatograph. Background Art

[0002] Liquid chromatographs are widely used in scientific research, drug analysis, environmental monitoring and other fields. During the normal operation of liquid chromatographs, mobile phase liquid needs to be continuously input into the system to ensure the continuity and accuracy of the analysis process. Therefore, it is very important to ensure the adequacy of mobile phase liquid. If the liquid chromatograph is operated without liquid, it will cause dry friction of the internal components of the instrument, which will significantly reduce the service life of the instrument and may even cause serious damage.

[0003] However, in the existing liquid chromatograph technology, the residual liquid monitoring and alarm mechanism in the solvent bottle is still not perfect. At present, the residual liquid in the solvent bottle is mainly monitored by manual observation. This method is not only inefficient, but also easy to cause the liquid to be exhausted due to human negligence, which in turn causes the liquid chromatograph to run idle without liquid, thereby causing damage to the instrument. In addition, the existing technology does not perform effective automatic monitoring and automatic alarm for the liquid in the solvent bottle of the liquid chromatograph, which has become an important bottleneck restricting the further development and application of liquid chromatographs. Summary of the invention

[0004] In view of the above-mentioned deficiencies in the prior art, the present invention provides an intelligent solvent remainder monitoring system and method for a liquid chromatograph, which solves the problem that the remaining amount of liquid in the existing solvent bottle is monitored and alarmed by manual observation, which not only has low work efficiency but also easily causes the liquid chromatograph to run idle in a liquid-free state and cause instrument damage.

[0005] To achieve the above purpose, the technical solution adopted by the present invention is: Provided is an intelligent residual monitoring system for a liquid chromatograph, comprising a control system and a liquid chromatograph body connected to the control system; the control system is connected to an alarm, a tray assembly is arranged on the top of the liquid chromatograph body, the tray assembly comprises a tray base and a solvent bottle tray arranged above the tray base, a plurality of placement slots are arranged on the top of the solvent bottle tray, solvent bottles are arranged in the placement slots, a weighing tray is arranged at the bottom, a weighing module is arranged at the bottom of the weighing tray, the weighing module comprises a weighing mainboard and a weighing sensor connected to the weighing mainboard, and a bottom plate is arranged below the weighing sensor.

[0006] The beneficial effects of adopting the above technical scheme are as follows: the control system can realize accurate monitoring and intelligent control of the remaining amount of solvent in the solvent bottle, ensuring the accuracy and efficiency of data monitoring; a plurality of placement slots arranged at the top of the solvent bottle tray in the tray assembly are convenient for neatly arranging and fixing multiple solvent bottles, thereby improving the utilization rate of the liquid chromatograph. At the same time, the tray base, as a fixed basis for the tray assembly, can ensure the stability of the tray assembly, thereby ensuring the stability and safety of the solvent bottle in the placement slot; and by setting a weighing sensor at the bottom of a single placement slot, and the weighing sensor adopts a cantilever sensor, the total mass of the solvent bottle and the solvent inside it can be collected in real time. The weighing mainboard can process the collected data in real time and efficiently by cooperating with the control system, and convert the mass information into volume information of the solvent, thereby improving the data accuracy and reliability of the residual monitoring system.

[0007] The residual monitoring system can realize real-time monitoring and automatic alarm of the liquid residual in the solvent bottle of the liquid chromatograph through the integration of the control system with the liquid chromatograph body, the tray assembly and the weighing module, thereby greatly improving the safety of the use of the liquid chromatograph; and through the coordinated use of the control system and the weighing module in the residual monitoring system, the residual solvent in the solvent bottle can be accurately and efficiently monitored, and the residual volume of the solvent can be displayed in real time. When the remaining volume is less than the preset alarm volume, the system will automatically alarm to avoid damage to the instrument operation due to solvent depletion, extend the service life of the system, and improve the work efficiency and safety of the staff.

[0008] Furthermore, a pallet cover plate is provided on the side of the pallet base, and the pallet cover plates are connected by a connecting block, and a pallet handle is provided on the connecting block.

[0009] The beneficial effects of adopting the above-mentioned further technical solution are as follows: the connecting block serves to connect the pallet cover plate, and the pallet cover plate is arranged on the side of the pallet base through the connecting block, which can ensure the stability of the solvent bottle on the pallet base during movement or use, and the pallet cover plate can also prevent the solvent from dripping directly onto the equipment or the ground when the solvent bottle is tipped over or leaked. In addition, the configuration of different numbers of weighing modules can be achieved by replacing the pallet cover plate; and the pallet handle arranged on the connecting block can further improve the stability of the solvent bottle.

[0010] Furthermore, an observation panel is provided on one side of the tray cover in the length direction, and a storage box is provided on one side of the tray cover in the short side direction.

[0011] The beneficial effects of adopting the above-mentioned further technical solution are as follows: the observation plate is made of transparent material, which is convenient for the staff to observe the remaining liquid volume in the solvent bottle, and the storage box can be used to store other materials, and is arranged on the side of the short side of the tray cover to avoid conflict with the observation plate, thereby having better practicality.

[0012] Furthermore, a pipeline clamp is provided on one side of the connecting block, and a liquid leakage drip tray is provided between the tray base and the solvent bottle tray.

[0013] The beneficial effects of adopting the above-mentioned further technical solution are as follows: the pipeline clamp arranged on one side of the connecting block can store the pipeline of the solvent bottle, thereby improving the stability and safety of use during the operation of the liquid chromatograph; and the leaking drip tray can quickly collect the leaked solvent and prevent the leaked solvent from spreading to other components, thereby improving the safety of the system.

[0014] The present invention provides an intelligent solvent residual monitoring method for a liquid chromatograph, comprising the following steps: S1: Preset the alarm volume value of the remaining solvent and confirm the quality of the empty solvent bottle; S2: Obtain the mass of the solvent bottle during processing through the weighing module; S3: Get the mass of the solvent in the solvent bottle; S4: Obtain the volume of the solvent in the solvent bottle during the treatment process through mass-volume conversion; S5: Compare the volume of the solvent in the solvent bottle with the alarm volume value; if the volume is ≥ the alarm volume value, the actual volume value is displayed; if the volume is < the alarm volume value, the system alarms.

[0015] Furthermore, the volume of the solvent in the solvent bottle during the treatment process is obtained based on the following formula:

[0016] Wherein, V is the actual volume of the solvent in a single solvent bottle during the use of the liquid chromatograph; M1 is the actual mass of a single solvent bottle monitored by the weighing module; M2 is the mass of the pre-confirmed empty solvent bottle; ρ is the density of the solvent in a single solvent bottle.

[0017] The beneficial effects of adopting the above-mentioned further technical scheme are as follows: the monitoring method obtains the mass of the solvent bottle by using the weighing module in real time, and calculates the actual volume of the solvent based on the mass-volume conversion formula. This real-time monitoring method ensures the accuracy and timeliness of the data, and effectively avoids damage to the system operation caused by solvent depletion caused by human observation; in addition, through the cooperation of the monitoring system and the monitoring method, the mass of the solvent bottle itself can be automatically removed during the monitoring process, and the volume conversion can be accurately performed according to the preset solvent density, and the volume can be displayed in real time on the host computer of the control system, which effectively reduces the work intensity of the staff and improves work efficiency; at the same time, when the solvent volume is lower than the preset volume alarm value, the monitoring system will automatically alarm, avoiding damage caused by the liquid chromatograph running under liquid-free conditions, greatly improving the safety and stability of the system.

[0018] Furthermore, when there are two or more solvents in a single solvent bottle, the density of the solvent in the solvent bottle during the processing is obtained based on the following formula:

[0019] Where ρ is the density of the solvent in a single solvent bottle; ρ i represents the density of the i-th liquid in a single solvent bottle, V i Represents the volume of the i-th solution in a single solvent bottle.

[0020] The beneficial effects of adopting the above-mentioned further technical scheme are as follows: the monitoring system and the monitoring method can freely select or set solvent bottles of different volumes and different solvent densities. When a single solvent bottle contains two or more solvents, the system can accurately calculate the density of the mixed solvent through the density calculation formula, and then obtain the precise solvent volume by coordinating with the volume calculation formula, which greatly improves work efficiency and has better economic benefits and practicality.

[0021] In summary, the intelligent residual monitoring system and monitoring method for liquid chromatograph provided by the present invention have the following beneficial effects: (1) The residual monitoring system in the present invention realizes accurate and intelligent monitoring of the residual amount of solvent in the solvent bottle by integrating the control system, alarm, liquid chromatograph body, tray assembly and weighing module, thereby ensuring the accuracy and efficiency of data monitoring; and the detection system also has real-time monitoring and automatic alarm functions, which reduces the workload of manual observation and avoids the operation of the liquid chromatograph under liquid-free conditions, thereby preventing dry friction of internal components of the system, reducing the risk of damage to the system due to solvent exhaustion, and extending the service life of the system.

[0022] (2) The residual monitoring system of the present invention can collect the total mass of the solvent bottle and the solvent inside it in real time by arranging a weighing module at the bottom of the tray assembly, and improve the accuracy and reliability of the collected data through mass-volume conversion.

[0023] (3) The monitoring method of the present invention can automatically alarm when the solvent volume is lower than the preset value by presetting the alarm volume value of the residual solvent, thereby avoiding the operation of the liquid chromatograph under liquid-free conditions and improving the safety of the system.

[0024] (4) The monitoring method of the present invention can freely select or set solvent bottles of different volumes and different solvent densities according to actual use requirements. When a single solvent bottle contains two or more solvents, the system can accurately calculate the density of the mixed solvent through the density calculation formula, and then obtain the precise solvent volume by combining it with the volume calculation formula, which greatly improves work efficiency and has better economic benefits and practicality. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Figure 1 It is a schematic diagram of the structure of the tray assembly in the present invention; Figure 2 It is a structural schematic diagram of the weighing module in the present invention; Figure 3 It is a schematic diagram of the structure of A in the present invention; Figure 4 is a flow chart of the monitoring method of the present invention; Figure 5 It is a system principle diagram of the monitoring method in the present invention; Among them, 1. tray assembly; 11. tray base; 12. solvent bottle tray; 13. placement slot; 14. solvent bottle; 15. tray cover; 16. connection block; 17. tray handle; 18. weighing tray; 19. observation plate; 110. storage box; 111. pipeline clamp; 112. leakage drip tray; 2. weighing module; 21. weighing sensor; 22. bottom plate; 23. weighing main board. DETAILED DESCRIPTION

[0026] The specific implementation modes of the present invention are described below to facilitate those skilled in the art to understand the present invention. However, it should be clear that the present invention is not limited to the scope of the specific implementation modes. For those of ordinary skill in the art, as long as various changes are within the spirit and scope of the present invention as defined and determined by the attached claims, these changes are obvious, and all inventions and creations utilizing the concept of the present invention are protected.

[0027] Example 1 like Figure 1 to Figure 3 As shown, this embodiment provides an intelligent solvent residual monitoring system for a liquid chromatograph, including a control system and a liquid chromatograph body connected to the control system; the control system is connected to an alarm, a tray assembly 1 is arranged on the top of the liquid chromatograph body, the tray assembly 1 includes a tray base 11 and a solvent bottle tray 12 arranged above the tray base 11, a plurality of placement slots 13 are arranged on the top of the solvent bottle tray 12, solvent bottles 14 are arranged in the placement slots 13, a weighing tray 18 is arranged at the bottom, a weighing module 2 is arranged at the bottom of the weighing tray 18, the weighing module 2 includes a weighing mainboard 23 and a weighing sensor 21 connected to the weighing mainboard 23, and a bottom plate 22 is arranged below the weighing sensor 21.

[0028] During implementation, the control system can realize accurate monitoring and intelligent control of the residual amount of solvent in the solvent bottle 14, ensuring the accuracy and efficiency of data monitoring; a plurality of placement slots 13 are arranged at the top of the solvent bottle tray 12 in the tray assembly 1, which facilitates the neat arrangement and fixation of multiple solvent bottles 14, thereby improving the utilization rate of the liquid chromatograph. At the same time, the tray base 11, as a fixed base of the tray assembly 1, can ensure the stability of the tray assembly 1, thereby ensuring the stability and safety of the solvent bottle 14 in the placement slot 13; and by setting a weighing sensor 21 at the bottom of a single placement slot 13, and the weighing sensor 21 adopts a cantilever sensor, the total mass of the solvent bottle 14 and the solvent therein can be collected in real time, and the weighing mainboard 23 can process the collected data in real time and efficiently by cooperating with the control system, and convert the mass information into volume information of the solvent, thereby improving the data accuracy and reliability of the residual monitoring system.

[0029] The residual monitoring system can realize real-time monitoring and automatic alarm functions of the liquid residual in the solvent bottle 14 of the liquid chromatograph through the integration of the control system with the liquid chromatograph body, the tray assembly 1 and the weighing module 2, thereby greatly improving the safety of the use of the liquid chromatograph; and through the coordinated use of the control system and the weighing module 2 in the residual monitoring system, the residual solvent in the solvent bottle 14 can be accurately and efficiently monitored, and the residual volume of the solvent can be displayed in real time. When the remaining volume is less than the preset alarm volume, the system will automatically alarm to avoid damage to the instrument operation due to solvent exhaustion, extend the service life of the system, and improve the work efficiency and safety of the staff.

[0030] like Figure 1 As shown, a pallet cover 15 is provided on the side of the pallet base 11, and the pallet cover 15 is connected by a connecting block 16, and a pallet handle 17 is provided on the connecting block 16; the connecting block 16 serves to connect the pallet cover 15, and the pallet cover 15 is provided on the side of the pallet base 11 through the connecting block 16, which can ensure the stability of the solvent bottle 14 on the pallet base 11 during movement or use, and the pallet cover 15 can also prevent the solvent from dripping directly onto the equipment or the ground when the solvent bottle 14 is dumped or leaked. In addition, the configuration of different numbers of weighing modules 2 can be achieved by replacing the pallet cover 15; and the pallet handle provided on the connecting block 16 can further improve the stability of the solvent bottle 14.

[0031] In addition, an observation plate 19 is provided on one side of the tray cover 15 in the length direction, and a storage box 110 is provided on one side of the short side direction; the observation plate 19 is made of a transparent material, which is convenient for the staff to observe the remaining liquid volume in the solvent bottle 14, and the storage box 110 can be used to store other materials, and is provided on one side of the short side direction of the tray cover 15 to avoid conflict with the observation plate 19, which has better practicality. A pipeline clamp 111 is provided on one side of the connection block 16, and a leaking drip tray 112 is provided between the tray base 11 and the solvent bottle tray 12; the pipeline clamp 111 provided on one side of the connection block 16 can store the pipeline of the solvent bottle 14, thereby improving the stability and safety of the use of the liquid chromatograph during operation; and the leaking drip tray 112 can quickly collect the leaked solvent, prevent the leaked solvent from spreading to other components, and improve the safety of the system.

[0032] The residual monitoring system in this embodiment realizes precise and intelligent monitoring of the residual amount of solvent in the solvent bottle 14 by integrating the control system, alarm, liquid chromatograph body, tray assembly 1 and weighing module 2, thereby ensuring the accuracy and efficiency of data monitoring; and the detection system also has real-time monitoring and automatic alarm functions, which reduces the workload of manual observation and avoids the operation of the liquid chromatograph under liquid-free conditions, thereby preventing dry friction of internal components of the system, reducing the risk of damage to the system due to solvent depletion, and extending the service life of the system.

[0033] Example 2 Based on Example 1, this embodiment provides a method for monitoring the residual amount of an intelligent solvent for a liquid chromatograph, comprising the following steps: S1: Preset the alarm volume value of the remaining solvent and confirm the quality of the empty solvent bottle; S2: Obtain the mass of the solvent bottle during processing through the weighing module; S3: Get the mass of the solvent in the solvent bottle; S4: Obtain the volume of the solvent in the solvent bottle during the treatment process through mass-volume conversion; S5: Compare the volume of the solvent in the solvent bottle with the alarm volume value; if the volume is ≥ the alarm volume value, the actual volume value is displayed; if the volume is < the alarm volume value, the system alarms.

[0034] In this embodiment, the volume of the solvent in the solvent bottle during the treatment process is obtained based on the following formula:

[0035] Wherein, V is the actual volume of the solvent in a single solvent bottle during the use of the liquid chromatograph; M1 is the actual mass of a single solvent bottle monitored by the weighing module; M2 is the mass of the pre-confirmed empty solvent bottle; ρ is the density of the solvent in a single solvent bottle.

[0036] The monitoring method obtains the mass of the solvent bottle by using a weighing module in real time, and calculates the actual volume of the solvent based on the mass-volume conversion formula. This real-time monitoring method ensures the accuracy and timeliness of the data, and effectively avoids damage to the system operation caused by solvent exhaustion due to human observation; in addition, through the coordination of the monitoring system and the monitoring method, the mass of the solvent bottle itself can be automatically removed during the monitoring process, and the volume conversion can be accurately performed according to the preset solvent density, and the volume can be displayed in real time on the host computer in the control system, which effectively reduces the workload of the staff and improves work efficiency; at the same time, when the solvent volume is lower than the preset volume alarm value, the monitoring system will automatically alarm, avoiding damage caused by the liquid chromatograph running under liquid-free conditions, greatly improving the safety and stability of the system.

[0037] Example 3 Based on Example 2, this example provides a formula for calculating the density of the solvent in the solvent bottle during the treatment process when there are two or more solvents in a single solvent bottle:

[0038] Where ρ is the density of the solvent in a single solvent bottle; ρ i represents the density of the i-th liquid in a single solvent bottle, V i Represents the volume of the i-th solution in a single solvent bottle.

[0039] After the system accurately calculates the density of the mixed solvent, the volume of the solvent in the solvent bottle during the processing process is obtained based on the following formula:

[0040] Wherein, V is the actual volume of the solvent in a single solvent bottle during the use of the liquid chromatograph; M1 is the actual mass of a single solvent bottle monitored by the weighing module; M2 is the mass of the pre-confirmed empty solvent bottle; ρ is the density of the solvent in a single solvent bottle.

[0041] The monitoring system and monitoring method can freely select or set solvent bottles of different volumes and different solvent densities. When a single solvent bottle contains two or more solvents, the system can accurately calculate the density of the mixed solvent through the density calculation formula, and then obtain the precise solvent volume by coordinating with the volume calculation formula, which greatly improves work efficiency and has better economic benefits and practicality.

[0042] In summary, the intelligent solvent remainder monitoring system and monitoring method for liquid phase chromatography provided by the present invention realize real-time monitoring and intelligent control of the remaining solvent in the solvent bottle through the integration of the control system, the weighing module and the alarm, and use the mass data collected in real time to calculate the actual volume of the solvent through the mass-volume conversion formula, thereby ensuring the accuracy and timeliness of the data; in addition, when the remaining solvent amount is lower than the preset alarm volume, the system will automatically alarm, effectively reducing the workload of manual observation, avoiding system damage caused by the operation of the liquid chromatograph under liquid-free conditions, and greatly improving the safety of system use.

Claims

1. An intelligent residual monitoring system for a liquid chromatograph, comprising a control system and a liquid chromatograph body connected to the control system, characterized in that: The control system is connected to the alarm, a tray assembly is arranged on the top of the liquid chromatograph body, the tray assembly includes a tray base and a solvent bottle tray arranged above the tray base, a plurality of placement slots are arranged on the top of the solvent bottle tray, solvent bottles are arranged in the placement slots, a weighing tray is arranged at the bottom, a weighing module is arranged at the bottom of the weighing tray, the weighing module includes a weighing mainboard and a weighing sensor connected to the weighing mainboard, and a bottom plate is arranged below the weighing sensor.

2. The intelligent residual monitoring system for liquid chromatograph according to claim 1, characterized in that: A pallet cover plate is arranged on the side of the pallet base, and the pallet cover plates are connected by a connecting block, and a pallet handle is arranged on the connecting block.

3. The intelligent residual monitoring system for liquid chromatograph according to claim 1, characterized in that: An observation plate is arranged on one side of the tray cover in the length direction, and a storage box is arranged on one side of the tray cover in the short side direction.

4. The intelligent residual monitoring system for liquid chromatograph according to claim 1, characterized in that: A pipeline clamp is arranged on one side of the connection block, and a liquid leakage drip tray is arranged between the tray base and the solvent bottle tray.

5. An intelligent solvent residual monitoring method for a liquid chromatograph, characterized in that: The following steps are involved: S1: Preset the alarm volume value of the remaining solvent and confirm the quality of the empty solvent bottle; S2: Obtain the mass of the solvent bottle during processing through the weighing module; S3: Get the mass of the solvent in the solvent bottle; S4: Obtain the volume of the solvent in the solvent bottle during the treatment process through mass-volume conversion; S5: Compare the volume of the solvent in the solvent bottle with the alarm volume value; if the volume is ≥ the alarm volume value, the actual volume value is displayed; if the volume is < the alarm volume value, the system alarms.

6. The intelligent solvent residual monitoring method for liquid chromatograph according to claim 5, characterized in that: The volume of solvent in the solvent bottle during the treatment process is obtained based on the following formula: Wherein, V is the actual volume of the solvent in a single solvent bottle during the use of the liquid chromatograph; M1 is the actual mass of a single solvent bottle monitored by the weighing module; M2 is the mass of the pre-confirmed empty solvent bottle; ρ is the density of the solvent in a single solvent bottle.

7. The intelligent solvent residual monitoring method for liquid chromatograph according to claim 5, characterized in that: When there are two or more solvents in a single solvent bottle, the density of the solvent in the solvent bottle during the processing is obtained based on the following formula: Where ρ is the density of the solvent in a single solvent bottle; ρ i represents the density of the i-th liquid in a single solvent bottle, V i Represents the volume of the i-th solution in a single solvent bottle.

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