Preparation method of high-transparency elastic cerebral aneurysm model

Abstract

The invention discloses a preparation method of a high-transparency elastic cerebral aneurysm model, and the method specifically comprises the following steps: S1, manufacturing a blood vessel model structure: selecting a transparent circular tube structure with a proper shape and size as a blood vessel structure, cutting an arc-shaped incision at a proper position of the middle part of the tube, the method comprises the following steps: S1, preparing an arc-shaped incision, and preparing an aneurysm spherical model of which the diameter is matched with the length of the arc-shaped incision, S2, preparing a container model, S3, installing a blood vessel model structure, S4, filling a filler, and S5, sealing and installing. The invention relates to the technical field of experimental models. According to the preparation method of the high-transparency elastic cerebral aneurysm model, the vasodilatation condition can be analyzed according to the actual simulated blood pressure condition while demonstration can be realized, the purposes of convenient demonstration and more comprehensive expression of the vascular elastic change condition can be well achieved, the functions of the cerebral aneurysm model are greatly enriched, and the development of the cerebral aneurysm model is facilitated. Therefore, experimental research on cerebral aneurysm is greatly facilitated.

Description

Technical Field

[0001] The invention relates to the technical field of experimental models, in particular to a method for preparing a highly transparent elastic cerebral aneurysm model. Background Art

[0002] Intracranial aneurysms are mostly abnormal bulges that occur on the walls of intracranial arteries. They are the leading cause of subarachnoid hemorrhage and the third most common cause of cerebrovascular accidents, after cerebral thrombosis and hypertensive cerebral hemorrhage. They can occur at any age, but most occur in middle-aged and elderly women between 40 and 60 years old. The cause of intracranial aneurysms is still unclear. Most scholars believe that intracranial aneurysms are caused by local congenital defects in the walls of intracranial arteries and increased intracavitary pressure. Hypertension, cerebral arteriosclerosis, and vasculitis are related to the occurrence and development of aneurysms. Intracranial aneurysms are more likely to occur on the basilar artery circle (Willis circle), of which 80% occur in the anterior half of the basilar artery circle. Intracranial aneurysms are more likely to occur at the bifurcation of the basilar artery circle and its main branches. About 85% of aneurysms are located in the internal carotid artery system in the anterior half of the Willis artery circle, i.e., the intracranial segment of the internal carotid artery, the anterior cerebral artery, the anterior communicating artery, the middle cerebral artery, and the posterior communicating artery. Before rupture and bleeding, 90% of patients with intracranial aneurysms have no obvious symptoms and signs. Only a very small number of patients have special manifestations due to the aneurysm affecting the adjacent nerves or brain structures. Aneurysm symptoms and signs can be roughly divided into pre-rupture warning symptoms, rupture bleeding symptoms, local positioning signs, and symptoms of increased intracranial pressure.

[0003] The existing cerebral aneurysm model has relatively simple functions. It can only demonstrate the principle of cerebral aneurysm, but cannot analyze the blood vessel expansion according to the actual simulated blood pressure conditions during the demonstration. It cannot achieve the purpose of facilitating demonstration and more comprehensively showing the changes in vascular elasticity, which brings great inconvenience to the experimental research of cerebral aneurysm. Summary of the invention

[0004] 1. Technical issues to be resolved

[0005] In view of the deficiencies in the prior art, the present invention provides a method for preparing a highly transparent elastic cerebral aneurysm model, which solves the problem that the existing cerebral aneurysm model has a relatively single function and only demonstrates the principle of cerebral aneurysm, but cannot analyze the blood vessel expansion according to the actual simulated blood pressure conditions during the demonstration, and cannot achieve the purpose of facilitating demonstration and more comprehensively showing the changes in vascular elasticity.

[0006] (II) Technical solution

[0007] To achieve the above objectives, the present invention is implemented by the following technical scheme: a method for preparing a highly transparent elastic cerebral aneurysm model, specifically comprising the following steps:

[0008] S1. Preparation of blood vessel model structure: Select a transparent circular tube structure of appropriate shape and size as the blood vessel structure, cut an arc-shaped incision at an appropriate position in the middle of the tube, and prepare an aneurysm spherical model with a diameter that matches the length of the arc-shaped incision, then apply adhesive to the arc-shaped incision, place the aneurysm spherical model into the arc-shaped incision, and keep it for 3-5 minutes to ensure that the aneurysm spherical model and the arc-shaped incision are stably adhered;

[0009] S2, making a container model: select a cylinder made of transparent glass as the container model, and open circular holes with sizes matching the size of the transparent circular tube in step S1 at the bottom of the left and right sides of the cylinder;

[0010] S3, installation of the blood vessel model structure: the blood vessel model structure with the aneurysm spherical model prepared in step S1 is installed in the container model prepared in step S2. During the installation process, adhesive is applied to two circular holes of the container model, and then the blood vessel model structure with the aneurysm spherical model is inserted into the circular holes and kept for 3-5 minutes, so that the blood vessel model structure with the aneurysm spherical model is stably adhered to the container model.

[0011] S4, filling material pouring: polydimethylsiloxane and curing agent are mixed by a mixing device, mixed and stirred for 10-20 minutes at a speed of 400-500 r / min and a temperature of 55-70° C., and then transferred to the container model installed in step S3, and allowed to stand and air-cool to room temperature, so that the mixed liquid in the container model is solidified into an elastic material;

[0012] S5. Sealing installation: Put the cylinder head on the top of the cylinder body, and seal and limit the cylinder head with sealing strips and buckles, then install a one-way exhaust valve that can only exhaust air out of the cylinder body at the exhaust hole position on the top of the cylinder head, and an air inlet is set on the top of the cylinder head, and a one-way valve that can only take air into the cylinder body is set in the air inlet.

[0013] Preferably, in step S1, the length of the transparent round tube is 30-50 cm, the diameter is 2-5 cm, and the wall thickness is 2-4 mm.

[0014] Preferably, the diameter of the aneurysm spherical model in step S1 is 8-15 mm.

[0015] Preferably, the transparent round tube in step S1 is made of a deformable elastic rubber material.

[0016] Preferably, the dimensions of the cylinder in step S2 are 28-46 cm in length, 10-15 cm in width, and 20-30 cm in height.

[0017] Preferably, in step S4, the ratio of polydimethylsiloxane to curing agent is 7-13:1.

[0018] Preferably, the curing agent in step S4 is one of polyisocyanate or epoxy resin.

[0019] Preferably, the one-way exhaust valve in step S5 is used to measure the gas exhausted from the container model when performing a simulation experiment on the elastic cerebral aneurysm model, so as to calculate the deformation caused by the aneurysm.

[0020] (III) Beneficial effects

[0021] The invention provides a method for preparing a highly transparent elastic cerebral aneurysm model. Compared with the prior art, the method for preparing the highly transparent elastic cerebral aneurysm model has the following beneficial effects: the method specifically comprises the following steps: S1, making a vascular model structure: selecting a transparent circular tube structure of suitable shape and size as the vascular structure, cutting an arc-shaped incision at a suitable position in the middle of the tube, and making an aneurysm spherical model with a diameter matching the length of the arc-shaped incision, and then applying an adhesive to the arc-shaped incision, placing the aneurysm spherical model into the arc-shaped incision, and keeping it for 3-5 minutes, so that the aneurysm spherical model and the arc-shaped incision are stably adhered; S2, making a container model: selecting a cylinder body made of transparent glass material as the container model, and opening circular holes with a size matching the size of the transparent circular tube in step S1 at the bottom of the left and right sides of the cylinder body; S3, installing the vascular model structure: installing the vascular model structure with the aneurysm spherical model made in step S1 into the container model in step S2, and applying an adhesive to the two circular holes of the container model during the installation process, and then inserting the vascular model structure with the aneurysm spherical model into the circular holes, and keeping it for 3-5 minutes, so that the vascular model with the dynamic The vascular model structure of the aneurysm spherical model is stably adhered to the container model; S4, filler perfusion: polydimethylsiloxane and curing agent are mixed by a mixing device, mixed and stirred for 10-20 minutes at a speed of 400-500r / min and a temperature of 55-70°C, and then transferred to the container model installed in step S3, and allowed to stand and air-cool to room temperature, so that the mixed liquid in the container model is solidified into an elastic material; S5, sealing installation: the cylinder cover is covered on the top of the cylinder body, and the cylinder cover is sealed and limited by a sealing strip and a buckle, and then a one-way exhaust valve that can only exhaust air out of the cylinder body is installed at the exhaust hole position on the top of the cylinder cover, and an air inlet is provided on the top of the cylinder cover, and a one-way valve that can only intake air into the cylinder body is provided in the air inlet, which can realize the analysis of blood vessel expansion according to the actual simulated blood pressure during the demonstration, and well achieves the purpose of facilitating demonstration and more comprehensively showing the change of blood vessel elasticity, greatly enriching the function of the cerebral aneurysm model, thereby greatly facilitating the experimental research of cerebral aneurysm. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 It is a flow chart of the present invention. DETAILED DESCRIPTION

[0023] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0024] See also Figure 1 The present invention provides three technical solutions: a method for preparing a highly transparent elastic cerebral aneurysm model, specifically including the following embodiments:

[0025] Example 1: A method for preparing a highly transparent elastic cerebral aneurysm model, comprising the following steps:

[0026] S1. Preparation of blood vessel model structure: Select a transparent circular tube structure of appropriate shape and size as the blood vessel structure, cut an arc-shaped incision at an appropriate position in the middle of the tube, and make an aneurysm spherical model with a diameter that matches the length of the arc-shaped incision, then apply adhesive to the arc-shaped incision, put the aneurysm spherical model into the arc-shaped incision, and keep it for 4 minutes to make the aneurysm spherical model adhere to the arc-shaped incision stably. The length of the transparent circular tube is 40 cm, the diameter is 3 cm, the wall thickness is 3 mm, and the diameter of the aneurysm spherical model is 11 mm. The transparent circular tube is made of deformable elastic rubber material;

[0027] S2. Making a container model: Select a cylinder made of transparent glass as the container model, and open circular holes with sizes matching the transparent round tube in step S1 at the bottom of the left and right sides of the cylinder. The size of the cylinder is 38 cm long, 13 cm wide, and 25 cm high;

[0028] S3, installation of the blood vessel model structure: the blood vessel model structure with the aneurysm spherical model prepared in step S1 is installed in the container model prepared in step S2. During the installation process, adhesive is applied to two circular holes of the container model, and then the blood vessel model structure with the aneurysm spherical model is inserted into the circular holes and kept for 4 minutes, so that the blood vessel model structure with the aneurysm spherical model is stably adhered to the container model.

[0029] S4, filling material pouring: polydimethylsiloxane and curing agent are mixed by a mixing device, mixed and stirred for 15 minutes at a speed of 450 r / min and a temperature of 62° C., and then transferred to the container model installed in step S3, and allowed to stand and cool to room temperature, so that the mixed liquid in the container model is solidified into an elastic material, the ratio of polydimethylsiloxane to curing agent is 11:1, and the curing agent is polyisocyanate;

[0030] S5. Sealing installation: Put the cylinder head on the top of the cylinder body and seal and limit the cylinder head with sealing strips and buckles, then install a one-way exhaust valve at the exhaust hole on the top of the cylinder head that can only exhaust air out of the cylinder body, and an air inlet is set on the top of the cylinder head, and a one-way valve is set in the air inlet that can only take air into the cylinder body. The one-way exhaust valve is used to measure the gas discharged from the container model when conducting a simulation experiment on the elastic cerebral aneurysm model, so as to convert the deformation caused by the aneurysm.

[0031] Example 2: A method for preparing a highly transparent elastic cerebral aneurysm model, comprising the following steps:

[0032] S1. Preparation of blood vessel model structure: Select a transparent circular tube structure of appropriate shape and size as the blood vessel structure, cut an arc-shaped incision at an appropriate position in the middle of the tube, and make an aneurysm spherical model with a diameter that matches the length of the arc-shaped incision, then apply adhesive to the arc-shaped incision, put the aneurysm spherical model into the arc-shaped incision, and keep it for 3 minutes to make the aneurysm spherical model adhere to the arc-shaped incision stably. The length of the transparent circular tube is 30 cm, the diameter is 2 cm, the wall thickness is 2 mm, and the diameter of the aneurysm spherical model is 8 mm. The transparent circular tube is made of deformable elastic rubber material;

[0033] S2. Making a container model: Select a transparent glass cylinder as the container model, and open circular holes with sizes matching the transparent round tube in step S1 at the bottom of the left and right sides of the cylinder. The size of the cylinder is 28 cm long, 10 cm wide, and 20 cm high;

[0034] S3, installation of the blood vessel model structure: the blood vessel model structure with the aneurysm spherical model prepared in step S1 is installed in the container model prepared in step S2. During the installation process, adhesive is applied to two circular holes of the container model, and then the blood vessel model structure with the aneurysm spherical model is inserted into the circular holes and kept for 3 minutes, so that the blood vessel model structure with the aneurysm spherical model is stably adhered to the container model.

[0035] S4, filling material pouring: polydimethylsiloxane and curing agent are mixed by a mixing device, mixed and stirred for 10 minutes at a speed of 400 r / min and a temperature of 55°C, and then transferred to the container model installed in step S3, and allowed to stand and cool to room temperature, so that the mixed liquid in the container model is solidified into an elastic material, the ratio of polydimethylsiloxane to curing agent is 7:1, and the curing agent is epoxy resin;

[0036] S5. Sealing installation: Put the cylinder head on the top of the cylinder body and seal and limit the cylinder head with sealing strips and buckles, then install a one-way exhaust valve at the exhaust hole on the top of the cylinder head that can only exhaust air out of the cylinder body, and an air inlet is set on the top of the cylinder head, and a one-way valve is set in the air inlet that can only take air into the cylinder body. The one-way exhaust valve is used to measure the gas discharged from the container model when conducting a simulation experiment on the elastic cerebral aneurysm model, so as to convert the deformation caused by the aneurysm.

[0037] Example 3: A method for preparing a highly transparent elastic cerebral aneurysm model, comprising the following steps:

[0038] S1. Preparation of blood vessel model structure: Select a transparent circular tube structure of appropriate shape and size as the blood vessel structure, cut an arc-shaped incision at an appropriate position in the middle of the tube, and make an aneurysm spherical model with a diameter that matches the length of the arc-shaped incision, then apply adhesive to the arc-shaped incision, put the aneurysm spherical model into the arc-shaped incision, and keep it for 5 minutes to make the aneurysm spherical model adhere to the arc-shaped incision stably. The length of the transparent circular tube is 50 cm, the diameter is 5 cm, the wall thickness is 4 mm, and the diameter of the aneurysm spherical model is 15 mm. The transparent circular tube is made of deformable elastic rubber material;

[0039] S2. Making a container model: Select a cylinder made of transparent glass as the container model, and open circular holes with sizes matching the transparent round tube in step S1 at the bottom of the left and right sides of the cylinder. The size of the cylinder is 46 cm long, 15 cm wide, and 30 cm high;

[0040] S3, installation of the blood vessel model structure: the blood vessel model structure with the aneurysm spherical model prepared in step S1 is installed in the container model prepared in step S2. During the installation process, adhesive is applied to two circular holes of the container model, and then the blood vessel model structure with the aneurysm spherical model is inserted into the circular holes and kept for 3-5 minutes, so that the blood vessel model structure with the aneurysm spherical model is stably adhered to the container model.

[0041] S4, filling material pouring: polydimethylsiloxane and curing agent are mixed by a mixing device, mixed and stirred for 20 minutes at a speed of 500 r / min and a temperature of 70°C, and then transferred to the container model installed in step S3, and allowed to stand and cool to room temperature, so that the mixed liquid in the container model is solidified into an elastic material, the ratio of polydimethylsiloxane to curing agent is 13:1, and the curing agent is polyisocyanate;

[0042] S5. Sealing installation: Put the cylinder head on the top of the cylinder body and seal and limit the cylinder head with sealing strips and buckles, then install a one-way exhaust valve at the exhaust hole on the top of the cylinder head that can only exhaust air out of the cylinder body, and an air inlet is set on the top of the cylinder head, and a one-way valve is set in the air inlet that can only take air into the cylinder body. The one-way exhaust valve is used to measure the gas discharged from the container model when conducting a simulation experiment on the elastic cerebral aneurysm model, so as to convert the deformation caused by the aneurysm.

[0043] In summary, the present invention can analyze the expansion of blood vessels according to the actual simulated blood pressure conditions while demonstrating, which well achieves the purpose of facilitating demonstration and more comprehensively showing the changes in vascular elasticity, greatly enriching the function of the cerebral aneurysm model, thereby greatly facilitating the experimental research of cerebral aneurysms.

[0044] Meanwhile, the contents not described in detail in this specification belong to the prior art known to those skilled in the art.

[0045] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device.

[0046] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A method for preparing a highly transparent elastic cerebral aneurysm model, characterized in that: The specific steps include: S1. Preparation of blood vessel model structure: Select a transparent circular tube structure of appropriate shape and size as the blood vessel structure, cut an arc-shaped incision at an appropriate position in the middle of the tube, and prepare an aneurysm spherical model with a diameter that matches the length of the arc-shaped incision, then apply adhesive to the arc-shaped incision, place the aneurysm spherical model into the arc-shaped incision, and keep it for 3-5 minutes to ensure that the aneurysm spherical model and the arc-shaped incision are stably adhered; S2, making a container model: select a cylinder made of transparent glass as the container model, and open circular holes with sizes matching the size of the transparent circular tube in step S1 at the bottom of the left and right sides of the cylinder; S3, installation of the blood vessel model structure: the blood vessel model structure with the aneurysm spherical model prepared in step S1 is installed in the container model prepared in step S2. During the installation process, adhesive is applied to two circular holes of the container model, and then the blood vessel model structure with the aneurysm spherical model is inserted into the circular holes and kept for 3-5 minutes, so that the blood vessel model structure with the aneurysm spherical model is stably adhered to the container model. S4, filling material pouring: polydimethylsiloxane and curing agent are mixed by a mixing device, mixed and stirred for 10-20 minutes at a speed of 400-500 r / min and a temperature of 55-70° C., and then transferred to the container model installed in step S3, and allowed to stand and air-cool to room temperature, so that the mixed liquid in the container model is solidified into an elastic material; S5. Sealing installation: Put the cylinder head on the top of the cylinder body, and seal and limit the cylinder head with sealing strips and buckles, then install a one-way exhaust valve that can only exhaust air out of the cylinder body at the exhaust hole position on the top of the cylinder head, and an air inlet is set on the top of the cylinder head, and a one-way valve that can only take air into the cylinder body is set in the air inlet.

2. The method for preparing a highly transparent elastic cerebral aneurysm model according to claim 1, characterized in that: In the step S1, the length of the transparent round tube is 30-50 cm, the diameter is 2-5 cm, and the wall thickness is 2-4 mm.

3. The method for preparing a highly transparent elastic cerebral aneurysm model according to claim 1, characterized in that: In step S1, the diameter of the aneurysm spherical model is 8-15 mm.

4. The method for preparing a highly transparent elastic cerebral aneurysm model according to claim 1, characterized in that: In step S1, the transparent round tube is made of deformable elastic rubber material.

5. The method for preparing a highly transparent elastic cerebral aneurysm model according to claim 1, characterized in that: The dimensions of the cylinder in step S2 are 28-46 cm in length, 10-15 cm in width, and 20-30 cm in height.

6. The method for preparing a highly transparent elastic cerebral aneurysm model according to claim 1, characterized in that: In the step S4, the ratio of polydimethylsiloxane to curing agent is 7-13:

1.

7. The method for preparing a highly transparent elastic cerebral aneurysm model according to claim 1, characterized in that: In step S4, the curing agent is one of polyisocyanate or epoxy resin.

8. The method for preparing a highly transparent elastic cerebral aneurysm model according to claim 1, characterized in that: The one-way exhaust valve in step S5 is used to measure the gas exhausted from the container model when performing a simulation experiment on the elastic cerebral aneurysm model, so as to calculate the deformation caused by the aneurysm.

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