Anti-allergy spray and preparation method thereof

Abstract

The invention relates to the technical field of skin care products, and particularly discloses an anti-allergy spray and a preparation method thereof. The anti-allergy spray is prepared from the following components in parts by mass: 74.98 to 84.89 parts of a solvent; 1 to 1.5 parts of an anti-inflammatory agent; 11 to 19 parts of a humectant; 0.8-1.2 parts of a preservative; 0.01 to 0.02 part of an auxiliary agent; 2.3 to 3.3 parts of a composite extract; the composite extract is prepared by compounding garcinia cambogia extract, goose liver extract, pigeon pea leaf extract and fenugreek extract. The traditional Chinese medicine composition has the advantage of better repairing the skin so as to achieve a more obvious and lasting anti-allergy effect.

Description

Technical Field

[0001] The invention relates to the field of skin care products, in particular to an anti-allergic spray and a preparation method thereof. Background Art

[0002] Sensitive skin refers to skin that is prone to discomfort symptoms such as stinging, burning, pain or itching when exposed to external stimuli. In order to relieve skin discomfort, anti-allergic skin care products are used to repair the skin so that the skin is less likely to experience discomfort due to irritation.

[0003] Although existing anti-allergic skin care products can relieve inflammation to a certain extent, they mainly relieve inflammation by adding anti-inflammatory ingredients. Although they can relieve skin discomfort during use, the effect of repairing the skin is not as expected, resulting in the nature of sensitive skin not changing. As a result, the skin is still prone to allergies under external stimuli, which makes it difficult to meet the needs of consumers. Therefore, there is still room for improvement. Summary of the invention

[0004] In order to better repair the skin to achieve a more significant and lasting anti-allergic effect, the present application provides an anti-allergic spray and a preparation method thereof.

[0005] In the first aspect, the present application provides an anti-allergic spray, which adopts the following technical solution: An anti-allergic spray comprising the following components in parts by mass: Solvent 74.98-84.89 parts; 1-1.5 parts of anti-inflammatory agent; Moisturizer 11-19 parts; Preservative 0.8-1.2 parts; Additives 0.01-0.02 parts; 2.3-3.3 parts of compound extract; The composite extract is a compound of garcinia cambogia extract, goose liver extract, pigeon pea leaf extract and fenugreek extract.

[0006] By adopting the above technical scheme, anti-inflammatory agents and moisturizers can quickly eliminate inflammation and relieve discomfort such as skin irritation. The composite extract composed of garcinia cambogia extract, goose liver extract, pigeon pea leaf extract and fenugreek extract can significantly inhibit the activity of hyaluronidase and promote the recovery of hyaluronic acid in the skin, so that the content of hyaluronic acid in the skin is quickly replenished, thereby achieving better skin repair, making the skin no longer sensitive and not prone to allergies due to external stimuli. Since the skin is well repaired, allergies are not prone to occur after the anti-allergic spray is discontinued, making the anti-allergic effect more lasting.

[0007] Preferably, the mass ratio of the garcinia cambogia extract, goose liver extract, pigeon pea leaf extract and fenugreek extract is 0.8-1.2: 0.6-0.8: 0.6-0.8: 0.3-0.5.

[0008] By adopting the above technical scheme and specifically selecting the mass ratio of Garcinia cambogia extract, goose liver extract, pigeon pea leaf extract and fenugreek extract, the active ingredients in each extract can better cooperate with each other, thereby exerting better soothing and anti-allergic effects and achieving better skin repair effects.

[0009] Preferably, the solvent is deionized water.

[0010] By adopting the above technical solution and specifically selecting deionized water, it is less irritating to the skin and is more easily absorbed by the skin, so that the active ingredients can better repair the skin and have a better anti-allergic effect.

[0011] Preferably, the anti-inflammatory agent is D-panthenol.

[0012] By adopting the above technical solution and specifically selecting D-panthenol, the anti-inflammatory effect is better, and it can quickly eliminate inflammation and quickly relieve skin discomfort.

[0013] Preferably, the moisturizing agent is a compound of butylene glycol, glycerol, glyceryl polyether-26 and betaine.

[0014] By adopting the above technical scheme and specifically selecting a moisturizer as a combination of butylene glycol, glycerol, glyceryl polyether-26, and betaine, a better moisturizing effect can be achieved, the skin can be quickly replenished with moisture, and skin discomfort can be better relieved.

[0015] Preferably, the mass ratio of butylene glycol, glycerol, glycerol polyether-26 and betaine is 3-5:5-7:1-3:2-4.

[0016] By adopting the above technical scheme and specifically selecting the mass ratio of butylene glycol, glycerol, glyceryl polyether-26 and betaine, the moisturizing effect is better, the effect of soothing skin discomfort is better and the effect is faster.

[0017] Preferably, the preservative is phenoxyethanol.

[0018] By adopting the above technical solution and specifically selecting phenoxyethanol as the preservative, the skin irritation is low and the preservative effect is better.

[0019] Preferably, the auxiliary agent is disodium ethylenediaminetetraacetate.

[0020] By adopting the above technical solution and specifically selecting disodium ethylenediaminetetraacetic acid as the auxiliary agent, the acidity and alkalinity can be better adjusted, so that the anti-allergic spray is less irritating to the skin and has a better anti-allergic effect.

[0021] In a second aspect, the present application provides a method for preparing an anti-allergic spray, using the following technical solution: A method for preparing the above-mentioned anti-allergic spray comprises the following steps: Step 1), mixing the solvent, moisturizing agent and auxiliary agent, heating to 80-85° C., and keeping the temperature for 30-40 minutes to obtain a premix; Step 2), cooling the premix to 40-45°C, then adding the anti-inflammatory agent, preservative, and compound extract, and stirring evenly to obtain an anti-allergic spray.

[0022] By adopting the above technical solution, the anti-allergic spray can quickly relieve skin discomfort, and can effectively inhibit hyaluronidase, promote the skin to quickly replenish hyaluronic acid, restore the skin to health, effectively improve allergic skin, make the skin less likely to recur allergies, and the anti-allergic effect is more lasting.

[0023] In summary, this application has the following beneficial effects: 1. Since the present application uses anti-inflammatory agents and moisturizers to quickly eliminate inflammation and relieve discomfort such as skin harassment, and the composite extract composed of garcinia cambogia extract, goose liver extract, pigeon pea leaf extract, and fenugreek extract can significantly inhibit the activity of hyaluronidase and promote the recovery of hyaluronic acid in the skin, so that the content of hyaluronic acid in the skin is quickly replenished, thereby achieving better skin repair, making the skin no longer sensitive and not prone to allergies due to external stimuli. Since the skin is well repaired, allergies are not prone to occur after the anti-allergic spray is discontinued, making the anti-allergic effect more lasting.

[0024] 2. In the present application, it is preferred to specifically select the mass ratio of Garcinia Cambogia Extract, Goose Liver Extract, Pigeon Pea Leaf Extract, and Fenugreek Extract so that the active ingredients in each extract can better cooperate with each other, thereby exerting a better soothing and anti-allergic effect and a better skin repair effect. DETAILED DESCRIPTION

[0025] The present application is further described in detail below with reference to the embodiments.

[0026] Example 1 An anti-allergic spray comprising the following components: Solvents, anti-inflammatory agents, moisturizers, preservatives, adjuvants, complex extracts.

[0027] The solvent was deionized water, which was purchased from Jinan Mingfeng Biotechnology Co., Ltd.

[0028] The anti-inflammatory agent was D-panthenol, which was purchased from Shanghai Quanyan Biotechnology Co., Ltd.

[0029] The moisturizer is a combination of butylene glycol, glycerin, glyceryl polyether-26 and betaine.

[0030] Butanediol was purchased from Chiping County Jinshun Chemical Co., Ltd., 1,3-butanediol.

[0031] Glycerol was purchased from Jinan Deying Chemical Co., Ltd.

[0032] Glycerol polyether-26 was purchased from Nantong Hengchuang Chemical Co., Ltd.

[0033] Betaine was purchased from Shaanxi Rankang Biotechnology Co., Ltd.

[0034] The preservative is phenoxyethanol, which was purchased from Rongsheng New Materials Technology (Nantong, Jiangsu) Co., Ltd.

[0035] The auxiliary agent is disodium ethylenediaminetetraacetate, which was purchased from Jinan Zhongbei Fine Chemical Co., Ltd.

[0036] The compound extract is a combination of garcinia cambogia extract, goose liver extract, pigeon pea leaf extract and fenugreek extract.

[0037] Garcinia cambogia extract was purchased from Shaanxi Bohong Health Industry Co., Ltd. It is a water-soluble extract with an extraction ratio of 10:1.

[0038] The goose liver extract was purchased from Shaanxi Bocuijian Biotechnology Co., Ltd., a water-soluble extract with a goose liver peptide content of 80%.

[0039] Pigeon pea leaf extract was purchased from Xi'an Ruierli Bioengineering Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0040] Fenugreek extract was purchased from Xi'an Ruierli Bioengineering Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0041] The preparation method of the anti-allergic spray comprises the following steps: Step 1), 84.89 kg of deionized water, 3 kg of butanediol, 5 kg of glycerol, 1 kg of glycerol polyether-26, 2 kg of betaine, and 0.01 kg of disodium ethylenediaminetetraacetate are put into a stirring kettle, the speed is 120 r / min, stirring is continued, heating to 80° C., and keeping warm for 30 minutes to obtain a premix.

[0042] Step 2), cooling the premix to 40°C, then adding 1kg D-panthenol, 0.8kg phenoxyethanol, 0.8kg garcinia cambogia extract, 0.6kg goose liver extract, 0.6kg pigeon pea leaf extract, 0.3kg fenugreek extract, rotating at 120r / min, stirring for 20min, to obtain an anti-allergic spray.

[0043] Example 2 An anti-allergic spray comprising the following components: Solvents, anti-inflammatory agents, moisturizers, preservatives, adjuvants, complex extracts.

[0044] The solvent was deionized water, which was purchased from Jinan Mingfeng Biotechnology Co., Ltd.

[0045] The anti-inflammatory agent was D-panthenol, which was purchased from Shanghai Quanyan Biotechnology Co., Ltd.

[0046] The moisturizer is a combination of butylene glycol, glycerin, glyceryl polyether-26 and betaine.

[0047] Butanediol was purchased from Chiping County Jinshun Chemical Co., Ltd., 1,3-butanediol.

[0048] Glycerol was purchased from Jinan Deying Chemical Co., Ltd.

[0049] Glycerol polyether-26 was purchased from Nantong Hengchuang Chemical Co., Ltd.

[0050] Betaine was purchased from Shaanxi Rankang Biotechnology Co., Ltd.

[0051] The preservative is phenoxyethanol, which was purchased from Rongsheng New Materials Technology (Nantong, Jiangsu) Co., Ltd.

[0052] The auxiliary agent is disodium ethylenediaminetetraacetate, which was purchased from Jinan Zhongbei Fine Chemical Co., Ltd.

[0053] The compound extract is a combination of garcinia cambogia extract, goose liver extract, pigeon pea leaf extract and fenugreek extract.

[0054] Garcinia cambogia extract was purchased from Shaanxi Bohong Health Industry Co., Ltd. It is a water-soluble extract with an extraction ratio of 10:1.

[0055] The goose liver extract was purchased from Shaanxi Bocuijian Biotechnology Co., Ltd., a water-soluble extract with a goose liver peptide content of 80%.

[0056] Pigeon pea leaf extract was purchased from Xi'an Ruierli Bioengineering Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0057] Fenugreek extract was purchased from Xi'an Ruierli Bioengineering Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0058] The preparation method of the anti-allergic spray comprises the following steps: Step 1), 79.935 kg of deionized water, 4 kg of butanediol, 6 kg of glycerol, 2 kg of glycerol polyether-26, 3 kg of betaine, and 0.015 kg of disodium ethylenediaminetetraacetate are put into a stirring kettle, the speed is 120 r / min, stirring is continued, heating to 82° C., and keeping warm for 35 minutes to obtain a premix.

[0059] Step 2), cooling the premix to 42°C, then adding 1.25kg D-panthenol, 1kg phenoxyethanol, 1kg garcinia cambogia extract, 0.7kg goose liver extract, 0.7kg pigeon pea leaf extract, 0.4kg fenugreek extract, rotating at 120r / min, stirring for 20min, to obtain an anti-allergic spray.

[0060] Example 3 An anti-allergic spray comprising the following components: Solvents, anti-inflammatory agents, moisturizers, preservatives, adjuvants, complex extracts.

[0061] The solvent was deionized water, which was purchased from Jinan Mingfeng Biotechnology Co., Ltd.

[0062] The anti-inflammatory agent was D-panthenol, which was purchased from Shanghai Quanyan Biotechnology Co., Ltd.

[0063] The moisturizer is a combination of butylene glycol, glycerin, glyceryl polyether-26 and betaine.

[0064] Butanediol was purchased from Chiping County Jinshun Chemical Co., Ltd., 1,3-butanediol.

[0065] Glycerol was purchased from Jinan Deying Chemical Co., Ltd.

[0066] Glycerol polyether-26 was purchased from Nantong Hengchuang Chemical Co., Ltd.

[0067] Betaine was purchased from Shaanxi Rankang Biotechnology Co., Ltd.

[0068] The preservative is phenoxyethanol, which was purchased from Rongsheng New Materials Technology (Nantong, Jiangsu) Co., Ltd.

[0069] The auxiliary agent is disodium ethylenediaminetetraacetate, which was purchased from Jinan Zhongbei Fine Chemical Co., Ltd.

[0070] The compound extract is a combination of garcinia cambogia extract, goose liver extract, pigeon pea leaf extract and fenugreek extract.

[0071] The preparation method of the anti-allergic spray comprises the following steps: Step 1), 74.98 kg of deionized water, 5 kg of butanediol, 7 kg of glycerol, 3 kg of glycerol polyether-26, 4 kg of betaine, and 0.02 kg of disodium ethylenediaminetetraacetate are put into a stirring kettle, the speed is 120 r / min, stirring is continued, heating to 85° C., and keeping warm for 40 minutes to obtain a premix.

[0072] Step 2), cooling the premix to 45°C, then adding 1.5kg D-panthenol, 1.2kg phenoxyethanol, 1.2kg garcinia cambogia extract, 0.8kg goose liver extract, 0.8kg pigeon pea leaf extract, 0.5kg fenugreek extract, rotating at 120r / min, stirring for 20min, to obtain an anti-allergic spray.

[0073] Garcinia cambogia extract was purchased from Shaanxi Bohong Health Industry Co., Ltd. It is a water-soluble extract with an extraction ratio of 10:1.

[0074] The goose liver extract was purchased from Shaanxi Bocuijian Biotechnology Co., Ltd., a water-soluble extract with a goose liver peptide content of 80%.

[0075] Pigeon pea leaf extract was purchased from Xi'an Ruierli Bioengineering Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0076] Fenugreek extract was purchased from Xi'an Ruierli Bioengineering Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0077] Comparative Example 1 An anti-allergic spray, compared with Example 2, the only difference is: In the composite extract, chamomile extract is used to replace garcinia cambogia extract in equal amounts.

[0078] Chamomile extract was purchased from Shaanxi New Horizon Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0079] Comparative Example 2 An anti-allergic spray, compared with Example 2, the only difference is: In the composite extract, purslane extract was used to replace goose liver extract in equal amounts.

[0080] Purslane extract was purchased from Gansu Yishengxiang Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0081] Comparative Example 3 An anti-allergic spray, compared with Example 2, the only difference is: In the composite extract, an equal amount of the Centella asiatica extract was used to replace the Cajanus cajan leaf extract.

[0082] Centella asiatica extract was purchased from Lanzhou Waterless Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0083] Comparative Example 4 An anti-allergic spray, compared with Example 2, the only difference is: In the composite extract, green tea extract was used to replace fenugreek extract in equal amounts.

[0084] Green tea extract was purchased from Xi'an Ruierli Bioengineering Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0085] Comparative Example 5 An anti-allergic spray, compared with Example 2, the only difference is: In the composite extract, chamomile extract was used to replace garcinia cambogia extract in an equal amount, purslane extract was used to replace goose liver extract in an equal amount, Centella asiatica extract was used to replace pigeon pea leaf extract in an equal amount, and green tea extract was used to replace fenugreek extract in an equal amount.

[0086] Chamomile extract was purchased from Shaanxi New Horizon Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0087] Purslane extract was purchased from Gansu Yishengxiang Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0088] Centella asiatica extract was purchased from Lanzhou Waterless Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0089] Green tea extract was purchased from Xi'an Ruierli Bioengineering Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0090] Experiment 1 According to T / SHRH 006-2018 "Experimental Method for Scavenging Cosmetics Free Radicals (DPPH)", the DPPH free radical scavenging rate (%) of the anti-allergic spray of each embodiment and comparative example was detected.

[0091] Experiment 2 According to T / JSRH 003-2023 "Hyaluronidase inhibition method for testing the anti-allergic activity of cosmetic raw materials", the hyaluronidase inhibition rate (%) of the anti-allergic spray of each embodiment and comparative example was tested.

[0092] The specific test data of Experiments 1 and 2 are shown in Table 1.

[0093] Table 1 According to the data comparison of each embodiment and comparative example in Table 1, the DPPH free radical scavenging rate and hyaluronidase inhibition rate of each embodiment are significantly higher than those of each comparative example. It can be seen that after adding the composite extract composed of garcinia cambogia extract, goose liver extract, pigeon pea leaf extract and fenugreek extract, the anti-allergic spray can not only play the role of superficial anti-inflammatory and moisturizing to relieve skin discomfort, but also can significantly inhibit hyaluronidase and scavenge DPPH free radicals, can well reduce the attack of free radicals, and promote the supplement of hyaluronic acid, so that the skin can recover health better, and allergic skin can be improved more thoroughly, so that the skin is not easy to be allergic, thereby making the anti-allergic effect more lasting.

[0094] In each comparative example, other extracts with soothing and anti-allergic effects are used to replace the Garcinia cambogia extract, goose liver extract, pigeon pea leaf extract, and fenugreek extract in the example alone or in whole. Although the comparative examples also have a certain effect of scavenging DPPH free radicals and inhibiting hyaluronidase, the special combination of Garcinia cambogia extract, goose liver extract, pigeon pea leaf extract, and fenugreek extract is destroyed, resulting in no significant improvement in the effects of scavenging DPPH free radicals and inhibiting hyaluronidase, making it difficult to achieve the effect of completely improving sensitive skin, so that the skin is still prone to allergies.

[0095] This specific embodiment is merely an explanation of the present application and is not a limitation of the present application. After reading this specification, those skilled in the art may make modifications to the present embodiment without any creative contribution as needed, but such modifications are protected by the patent law as long as they are within the scope of the claims of the present application.

Claims

1. An anti-allergic spray, characterized in that: The composition includes the following components in parts by weight: Solvent 74.98-84.89 parts; 1-1.5 parts of anti-inflammatory agent; Moisturizer 11-19 parts; Preservative 0.8-1.2 parts; Additives 0.01-0.02 parts; 2.3-3.3 parts of compound extract; The composite extract is a compound of garcinia cambogia extract, goose liver extract, pigeon pea leaf extract and fenugreek extract.

2. An anti-allergic spray according to claim 1, characterized in that: The mass ratio of the garcinia cambogia extract, the goose liver extract, the pigeon pea leaf extract and the fenugreek extract is 0.8-1.2: 0.6-0.8: 0.6-0.8: 0.3-0.

5.

3. The anti-allergic spray according to claim 1, characterized in that: The solvent is deionized water.

4. The anti-allergic spray according to claim 1, characterized in that: The anti-inflammatory agent is D-panthenol.

5. The anti-allergic spray according to claim 1, characterized in that: The moisturizing agent is a compound of butylene glycol, glycerol, glyceryl polyether-26 and betaine.

6. The anti-allergic spray according to claim 5, characterized in that: The mass ratio of the butanediol, glycerol, glycerol polyether-26 and betaine is 3-5:5-7:1-3:2-4.

7. The anti-allergic spray according to claim 1, characterized in that: The preservative is phenoxyethanol.

8. The anti-allergic spray according to claim 1, characterized in that: The auxiliary agent is disodium ethylenediaminetetraacetate.

9. A method for preparing the anti-allergic spray according to any one of claims 1 to 8, characterized in that: The following steps are involved: Step 1), the solvent, moisturizer and auxiliary agent are mixed, heated to 80-85°C, and kept warm for 30-40 minutes to obtain a premix; Step 2), cool the premix to 40-45°C, then add the anti-inflammatory agent, preservative, and compound extract, stir evenly, and obtain the anti-allergic spray.

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