Cooling precipitation device for amantadine hydrochloride production

Abstract

The invention discloses a cooling precipitation device for amantadine hydrochloride production in the technical field of amantadine hydrochloride production, and the cooling precipitation device comprises a box body, a semiconductor cooler, a transfer mechanism, a fixing mechanism and a stripping mechanism, and the transfer mechanism comprises a lifting track, a translation track, a turntable, a lifting seat and a translation seat. The fixing mechanism is used for fixing the seed crystals, the rotary table rotates intermittently, and every time the rotary table rotates once, the two seed crystals change positions, that is, the seed crystals in the precipitation cavity move to the stripping cavity, the seed crystals in the stripping cavity move to the precipitation cavity, the seed crystals in the precipitation cavity are used for realizing precipitation of amantadine hydrochloride, and the stripping mechanism enables crystals on the seed crystals in the stripping cavity to fall off. Therefore, automatic crystallization separation and crystal collection of amantadine hydrochloride are realized, manual crystal collection is not needed, and the production convenience is improved.

Description

Technical Field

[0001] The invention relates to the technical field of amantadine hydrochloride production, and in particular to a cooling and precipitation device for amantadine hydrochloride production. Background Art

[0002] Amantadine hydrochloride is an organic compound with the chemical formula C10H18ClN. It can inhibit viruses from penetrating into host cells, affect the uncoating of viruses, inhibit their reproduction, and play a role in treating and preventing viral infections.

[0003] When producing amantadine hydrochloride, a solution is first prepared, and then the amantadine hydrochloride is crystallized and precipitated on a seed crystal by cooling the solution. A Chinese patent with patent application number: 202321955062.9 discloses a cooling and precipitation device for producing amantadine hydrochloride. Through the coordinated use of coils, connecting pipes, water inlet pipes, support plates, water outlet pipes, heat dissipation shells, curved pipes, water pumps and reflux pipes, the water source is diverted in the heat dissipation shell, and the water pump is started to bring the water source in the water outlet pipe into the reflux pipe through the curved pipe. The provision of multiple heat dissipation shells increases the heat exchange area between the coolant and the air, thereby increasing the heat exchange efficiency.

[0004] Although the above patent can cool the solution well, as the amount of adamantane hydrochloride precipitated on the seed crystal increases, the precipitated crystals need to be separated from the seed crystal to achieve crystal removal and recovery. The above patent cannot achieve automatic collection of crystals. Summary of the invention

[0005] In order to solve the above problems, the present invention provides a cooling and precipitation device for producing amantadine hydrochloride, and the present invention is achieved through the following technical solutions.

[0006] A cooling and precipitation device for amantadine hydrochloride production, comprising a box, a semiconductor refrigerator, a transfer mechanism, a fixing mechanism and a material removal mechanism;

[0007] The box body is symmetrically fixed with partitions, which divide the box body into a precipitation chamber in the middle and material removal chambers on both sides. The material removal chamber is fixed with an inclined sliding plate, and the left and right side plates of the box body are provided with discharge ports at positions corresponding to the heads of the sliding plates.

[0008] The bottom of the left partition is fixedly connected with a mounting frame, the semiconductor refrigerator is fixedly connected to the right side plate of the mounting frame, the semiconductor refrigerator includes a PN junction and a hot end and a cold end connected to the left and right sides of the PN junction, and the hot end is evenly fixedly connected with heat dissipation fins in the longitudinal direction;

[0009] The transfer mechanism includes a lifting rail, a translation rail, a turntable, a lifting seat and a translation seat; the box body is symmetrically fixed with bracket plates, and a driving box is fixedly connected to the top of the bracket plate on the right side, the lifting rail is fixedly connected between the bracket plates, and positioning grooves are opened on both sides of the lifting rail. The lifting rail is "double-peaked", and the two peaks of the lifting rail are aligned with the partition plate. The translation rail is fixedly connected to the top of the lifting rail, and the first rotating shaft is rotatably connected to the top plate of the driving box. The turntable is fixedly connected to the top of the first rotating shaft, and the second rotating shaft is rotatably connected between the front and rear side plates of the driving box. The first rotating shaft and the second rotating shaft are linked by a bevel gear pair, and the transmission ratio of the first rotating shaft to the second rotating shaft is 1:1. A self-locking motor is fixedly connected to the front side of the driving box. The machine is used to drive the second rotating shaft to rotate intermittently 180°, the lifting seat is slidably connected in the lifting track, and the front and rear sides of the lifting seat are fixedly connected with positioning pins, and the positioning pins are slidably connected in the positioning grooves. There are two lifting seats, and when one lifting seat is located in the middle of the precipitation chamber, the other lifting seat is located in the material removal chamber, and the translation seat is slidably connected in the translation track. The translation seat is located directly above the lifting seat, and a connecting rod is fixedly connected between the translation seats, and a suspension rod is fixedly connected below the translation seat, and the suspension rod is slidably connected to the lifting seat, and a first pin shaft is fixedly connected to the translation seat on the left side, and a second pin shaft is fixedly connected to the turntable, and a connecting rod is hinged between the first pin shaft and the second pin shaft, and the distance between the second pin shaft and the center of the turntable is equal to half of the distance between the two translation seats;

[0010] The fixing mechanism is arranged below the lifting seat, and is used to fix the seed crystal;

[0011] The stripping mechanism is arranged in the stripping cavity and is used to make the crystals precipitated on the seed crystals fall off.

[0012] Preferably, a temperature sensor is fixedly connected to the bottom of the precipitation chamber, and a PLC controller and a first switch are fixedly connected to the front side of the box body. The model of the PLC controller is STC15W201S. The PLC controller has a timer and a comparator. The power interface of the PLC controller is electrically connected to the first external power supply through the first switch, the temperature sensor is electrically connected to the signal input end of the PLC controller through the comparator, the control output end of the PLC controller is electrically connected to the semiconductor refrigerator, and the control output end of the PLC controller is also electrically connected to the self-locking motor through the timer. The PLC controller controls the intermittent rotation of the self-locking motor for a fixed period of time through the timer. Within the fixed period of time, the self-locking motor rotates 180°.

[0013] Preferably, the fixing mechanism includes a fixing seat and an elastic strap; the fixing seat is connected to the bottom of the lifting seat through a spring seat, the fixing seat is a regular hexagon, a locking pin is fixedly connected to the side of the fixing seat, a locking head is fixedly connected to the head of the locking pin, one end of the elastic strap is fixedly connected to the side of the fixing seat, the other end of the elastic strap is fixedly connected to a fixing plate, the elastic strap and the locking pin are alternately arranged, a through hole is provided on the fixing plate, a locking groove is provided on the side of the through hole away from the elastic strap, the diameter of the through hole is larger than the diameter of the locking head, the width of the locking groove is larger than the diameter of the locking pin and smaller than the diameter of the locking head.

[0014] Preferably, the stripping mechanism includes a stripping motor and a beating rod, the stripping motor is fixedly connected to the bottom of the stripping chamber, the stripping motor is provided with a vertically upward output shaft, the output shaft is rotatably connected to the sliding plate, the beating rod is symmetrically fixedly connected to the top of the output shaft, and the height of the beating rod is consistent with the fixed seat.

[0015] Preferably, a pair of first metal sheets are symmetrically fixed to the left side of the groove body of the translation track, and a pair of second metal sheets are symmetrically fixed to the middle part of the groove body of the translation track. The translation seat on the left side is made of metal, and a second switch is fixed to the front side of the box body. It also includes a second external power supply, one pole of the second external power supply is electrically connected to one of the first metal sheets and the second metal sheet, and the other pole of the second external power supply is electrically connected to one of the terminals of the two stripping motors through the second switch, the other terminal of the stripping motor on the left side is electrically connected to the other first metal sheet, and the other terminal of the stripping motor on the right side is electrically connected to the other second metal sheet.

[0016] Preferably, a groove is provided at the bottom of the front side plate of the box body at a position corresponding to the precipitation chamber, a reverse osmosis membrane is fixedly connected to the opening of the groove, extrusion ports are densely distributed at positions corresponding to the groove on the box body, a cover shell is fixedly connected to the front side of the box body, the cover shell covers the extrusion port therein, a drain pipe is fixedly connected to the top of the cover shell, a spring telescopic rod is fixedly connected to the front side plate of the cover shell, a seat plate is fixedly connected to the head of the spring telescopic rod, a sealing column corresponding to the extrusion port is fixedly connected to the seat plate, a pressure plate is sealingly and slidably connected in the precipitation chamber, a through hole is provided on the pressure plate, and the bottom of the precipitation chamber corresponds to the position of the through hole A vertical rod is fixedly connected, and the diameter of the vertical rod is consistent with the through hole. A guide rod is fixedly connected to the inner wall of the partition, and the pressure plate is slidably connected to the guide rod. A return spring is sleeved on the guide rod above the pressure plate, and the two ends of the return spring are respectively fixedly connected to the partition and the pressure plate. A third rotating shaft is rotatably connected to the top of the pressure plate, and a cam is evenly fixedly connected to the third rotating shaft in the longitudinal direction, and the cam abuts against the pressure plate. A support plate is fixedly connected to the rear side of the bracket plate on the right side, and the second rotating shaft is rotatably connected to the support plate, and the rear ends of the third rotating shaft and the second rotating shaft are fixedly connected to transmission wheels, and the two transmission wheels are linked by belts.

[0017] Preferably, a liquid storage cylinder is fixedly connected to the rear side of the box body, a liquid supply tube is fixedly connected to the bottom of the liquid storage cylinder, the head of the liquid supply tube is fixedly connected to the rear side plate of the box body, the connection position of the liquid supply tube and the box body is located at the upper left corner of the precipitation chamber, and a floating frame is fixedly connected to the inner wall of the box body, and a floating seat is slidably connected inside the floating frame.

[0018] Preferably, the drain pipe passes through the heat dissipation fins in a serpentine shape.

[0019] The beneficial effects of the present invention are as follows:

[0020] 1. The fixing mechanism is used to fix the crystal seeds, and the turntable rotates intermittently. Every time the turntable rotates once, the two crystal seeds are exchanged, that is, the crystal seeds in the precipitation chamber move to the dematerializing chamber, and the crystal seeds in the dematerializing chamber move to the precipitation chamber. The crystal seeds in the precipitation chamber are used to realize the precipitation of amantadine hydrochloride. The dematerializing mechanism causes the crystals on the crystal seeds in the dematerializing chamber to fall off, thereby realizing the automatic crystallization and collection of amantadine hydrochloride, without the need for manual collection of crystals, and improving the convenience of production.

[0021] 2. When amantadine hydrochloride in the solution is continuously precipitated, the concentration of the solution will decrease. The present application can squeeze out the water in the solution, increase the concentration of the solution, and realize automatic liquid replenishment, thereby increasing the crystallization rate of amantadine hydrochloride. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] In order to more clearly illustrate the technical solution of the present invention, the drawings required for use in the description of the specific implementation methods will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0023] Figure 1 : An axonometric view of a cooling and precipitation device for producing amantadine hydrochloride according to the present invention;

[0024] Figure 2 : A three-dimensional schematic diagram of the rear side of a cooling and precipitation device for producing amantadine hydrochloride according to the present invention;

[0025] Figure 3 : A schematic diagram of the internal structure of the box body of the present invention;

[0026] Figure 4 : A cross-sectional view of a cooling and precipitation device for producing amantadine hydrochloride according to the present invention;

[0027] Figure 5 : Figure 4 A partial enlarged view of point A shown;

[0028] Figure 6 : A driving schematic diagram of the turntable of the present invention;

[0029] Figure 7 : A three-dimensional schematic diagram of the lifting track of the present invention;

[0030] Figure 8 : A schematic diagram of the structure of the translation track of the present invention;

[0031] Fig. 9 : A schematic diagram of the connection between the lifting seat and the translation seat of the present invention;

[0032] Fig.10 : A schematic diagram of the circuit connection of the PLC controller of the present invention;

[0033] Fig.11 : Figure 4 A partial enlarged view of point B shown;

[0034] Fig.12 : A three-dimensional schematic diagram of the fixing mechanism of the present invention;

[0035] Fig.13 : A schematic diagram of the circuit connection of the stripping motor of the present invention;

[0036] Fig.14 : A partial cross-sectional view of the position of the reverse osmosis membrane of the present invention;

[0037] Fig.15 : A schematic diagram of the internal structure of the cover shell of the present invention;

[0038] Fig.16 : Schematic diagram of the installation of the reverse osmosis membrane of the present invention;

[0039] Fig.17 : A schematic diagram of the installation of the floating seat of the present invention;

[0040] Fig.18 : Schematic diagram of the connection between the drain pipe and the heat dissipation fins described in the present invention.

[0041] The reference numerals are as follows:

[0042] 1-box, 11-partition, 12-separation chamber, 13-material removal chamber, 14-sliding plate, 15-discharging port;

[0043] 2-semiconductor refrigerator, 201-PN junction, 202-hot end, 203-cold end, 21-mounting frame, 22-heat dissipation fins;

[0044] 31-lifting track, 32-translation track, 33-turntable, 34-lifting seat, 35-translation seat, 36-bracket plate, 37-driving box, 38-positioning slot, 39-first rotating shaft, 310-second rotating shaft, 311-bevel gear pair, 312-self-locking motor, 313-positioning pin, 314-connecting rod, 315-suspending rod, 316-first pin shaft, 317-second pin shaft, 318-connecting rod;

[0045] 4-fixing mechanism, 401-crystal seed, 41-fixing seat, 42-elastic strap, 43-spring seat, 44-locking pin, 45-locking head, 46-fixing plate, 47-through hole, 48-locking slot;

[0046] 5-stripping mechanism, 51-stripping motor, 52-beating rod, 53-output shaft, 54-first metal sheet, 55-second metal sheet, 56-second switch, 57-second external power supply;

[0047] 61 - temperature sensor, 62 - PLC controller, 63 - first switch, 64 - timer, 65 - comparator, 66 - first external power supply;

[0048] 71-groove, 72-reverse osmosis membrane, 73-extrusion port, 74-cover, 75-drain pipe, 76-spring telescopic rod, 77-seat plate, 78-sealing column, 79-pressing plate, 710-through hole, 711-vertical rod, 712-guide rod, 713-reset spring, 714-third rotating shaft, 715-cam, 716-support plate, 717-transmission wheel, 718-belt;

[0049] 81 - liquid storage cylinder, 82 - liquid supply pipe, 83 - floating frame, 84 - floating seat. DETAILED DESCRIPTION

[0050] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0051] like Figure 1-18 As shown, the present invention has the following three specific embodiments.

[0052] Example 1

[0053] A cooling and precipitation device for producing amantadine hydrochloride, comprising a housing 1, a semiconductor refrigerator 2, a transfer mechanism, a fixing mechanism 4 and a material removal mechanism 5;

[0054] The box body 1 is symmetrically fixed with partitions 11, which divide the box body 1 into a precipitation chamber 12 in the middle and material removal chambers 13 on both sides. The material removal chambers 13 are fixed with inclined sliding plates 14. The left and right side plates of the box body 1 are provided with discharge ports 15 at positions corresponding to the heads of the sliding plates 14.

[0055] The bottom of the left partition 11 is fixedly connected with a mounting frame 21, and the semiconductor refrigerator 2 is fixedly connected to the right side plate of the mounting frame 21. The semiconductor refrigerator 2 includes a PN junction 201 and a hot end 202 and a cold end 203 connected to the left and right sides of the PN junction 201. The hot end 202 is evenly fixedly connected with heat dissipation fins 22 in the longitudinal direction.

[0056] The transfer mechanism includes a lifting rail 31, a translation rail 32, a turntable 33, a lifting seat 34 and a translation seat 35; the box body 1 is symmetrically fixed with support plates 36, and a driving box 37 is fixed to the top of the support plate 36 on the right side. The lifting rail 31 is fixed between the support plates 36, and positioning grooves 38 are provided on both sides of the lifting rail 31. The lifting rail 31 is a "double-peaked" shape, and the two peaks of the lifting rail 31 are aligned with the partition 11. The translation rail 32 is fixed above the lifting rail 31, and a first rotating shaft 39 is rotatably connected to the top plate of the driving box 37. The turntable 33 is fixed to the top of the first rotating shaft 39, and a second rotating shaft 310 is rotatably connected between the front and rear side plates of the driving box 37. The first rotating shaft 39 and the second rotating shaft 310 are linked by a bevel gear pair 311. The transmission ratio of the first rotating shaft 39 to the second rotating shaft 310 is 1:1. A self-locking motor 312 is fixed to the front side of the driving box 37, and the self-locking motor 312 is used to drive The second rotating shaft 310 intermittently rotates 180 degrees, and the lifting seat 34 is slidably connected to the lifting track 31. The front and rear sides of the lifting seat 34 are fixed with positioning pins 313, and the positioning pins 313 are slidably connected to the positioning groove 38. There are two lifting seats 34. When one lifting seat 34 is located in the middle of the precipitation chamber 12, the other lifting seat 34 is located in the stripping chamber 13. The translation seat 35 is slidably connected to the translation track 32. The translation seat 35 is located at the lifting seat 34. A connecting rod 314 is fixed between the translation seats 35, a suspension rod 315 is fixed below the translation seats 35, the suspension rod 315 is slidably connected to the lifting seat 34, a first pin 316 is fixed to the translation seat 35 on the left, a second pin 317 is fixed to the turntable 33, a connecting rod 318 is hinged between the first pin 316 and the second pin 317, and the distance between the second pin 317 and the center of the turntable 33 is equal to half the distance between the two translation seats 35;

[0057] The fixing mechanism 4 is disposed below the lifting seat 34 and is used to fix the seed crystal 401;

[0058] The stripping mechanism 5 is disposed in the stripping chamber 13 and is used to make the crystals precipitated on the seed crystal 401 fall off.

[0059] In this embodiment, Figure 6 As shown, when the self-locking motor 312 is working, it drives the second rotating shaft 310 to rotate, and the second rotating shaft 310 drives the first rotating shaft 39 and the turntable 33 to rotate through the bevel gear pair 311. Since the self-locking motor 312 drives the second rotating shaft 310 to rotate 180° intermittently, and the transmission ratio of the first rotating shaft 39 and the second rotating shaft 310 is 1:1, when the self-locking motor 312 is working, it drives the turntable 33 to rotate 180° intermittently, and the turntable 33 drives the translation seat 35 on the left side to move through the connecting rod 318. Under the action of the connecting rod 314, the translation seat 35 on the right side moves synchronously.

[0060] like Figure 3 and 4 As shown, in the initial state, the left and right translation seats 35 are respectively located in the middle and right sides of the translation track 32. When the turntable 33 rotates 180°, the middle translation seat 35 moves to the left side, and the right translation seat 35 moves to the middle, thereby realizing the replacement of the two translation seats 35. When the turntable 33 continues to rotate 180°, the left and right translation seats 35 move to the middle and right sides of the translation track 32 respectively.

[0061] The translation seat 35 drives the lifting seat 34 to translate through the suspension rod 315. Figure 7 and 9 As shown, the suspension rod 315 is slidably connected to the lifting seat 34, and the lifting seat 34 is slidably connected in the positioning groove 38 through the positioning pin 313. When the lifting seat 34 moves horizontally, it moves along the path of the lifting track 31, and the position corresponding to the partition 11 on the lifting track 31 is provided with two peaks, that is, when the lifting seat 34 moves to the position of the peak, it is at the highest point, so that the lifting seat 34 and the fixing mechanism 4 can smoothly pass through the partition 11. The movement of the middle lifting seat 34 to the right is taken as an example for explanation. The middle lifting seat 34 is located at a low point, and its bottom is fixed with a seed 401 by the fixing mechanism 4, and the seed 401 is inserted into the solution. When the lifting seat 34 moves to the right, it will rise to the highest point at the peak position on the right, so that the seed 401 can smoothly pass through the partition 11 on the right. After passing through the partition 11, the seed 401 will drop again, and the seed 401 falls into the dematerializing chamber 13 on the right.

[0062] like Figure 1-4 As shown, the precipitation chamber 12 is used to contain the amantadine hydrochloride solution, and the fixing mechanism 4 fixes the seed crystal 401 at the bottom of the lifting seat 34, as shown in FIG. Figure 5 As shown, when the semiconductor refrigerator 2 is working, the solution is cooled through the cold end 203, and the hot end 202 dissipates heat through the heat dissipation fins 22. The front and rear ends of the mounting frame 21 are open to facilitate heat dissipation.

[0063] In the initial state, the left and right seed crystals 401 are respectively located in the precipitation chamber 12 and the right dematerializing chamber 13. The seed crystal 401 on the left is used to precipitate the adamantane hydrochloride in the solution. Under the action of the dematerializing mechanism 5, the crystals on the seed crystal 401 on the right fall off and are discharged through the sliding plate 14 and the discharge port 15. A collection box can be used at the position of the discharge port 15 to receive the crystals.

[0064] Then the turntable 33 rotates 180°, the two seed crystals 401 are switched, the seed crystal 401 on the right enters the solution to precipitate crystals, and the seed crystal 401 on the left moves to the left stripping chamber 13 , and the crystals on the seed crystal 401 fall off under the action of the stripping mechanism 5 .

[0065] As a further implementation method of this embodiment, a temperature sensor 61 is fixedly connected to the bottom of the precipitation chamber 12, and a PLC controller 62 and a first switch 63 are fixedly connected to the front side of the box body 1. The model of the PLC controller 62 is STC15W201S. The PLC controller 62 is equipped with a timer 64 and a comparator 65. The power interface of the PLC controller 62 is electrically connected to the first external power supply 66 through the first switch 63, the temperature sensor 61 is electrically connected to the signal input end of the PLC controller 62 through the comparator 65, the control output end of the PLC controller 62 is electrically connected to the semiconductor refrigerator 2, and the control output end of the PLC controller 62 is also electrically connected to the self-locking motor 312 through the timer 64. The PLC controller 62 controls the intermittent rotation of the self-locking motor 312 for a fixed duration through the timer 64. During the fixed duration, the self-locking motor 312 rotates 180°.

[0066] like Figure 1 , 3 As shown in 10, the self-locking motor 312 and the semiconductor refrigerator 2 can be powered on by the first switch 63, and the semiconductor refrigerator 2 cools the solution. The temperature of the solution is monitored by the temperature sensor 61 and transmitted to the comparator 65 for comparison. The upper and lower thresholds of the temperature are set in the comparator 65. When the monitored temperature is greater than the upper threshold, the semiconductor refrigerator 2 is started, and when the temperature is less than the lower threshold, the semiconductor refrigerator 2 stops working, so that the temperature of the solution is maintained within a certain range, thereby increasing the speed of crystal precipitation.

[0067] The PLC controller 62 controls the intermittent operation of the self-locking motor 312 through the timer 64 . The self-locking motor 312 rotates 180° when working, thereby realizing the intermittent 180° rotation of the turntable 33 .

[0068] As a further implementation method of this embodiment, the fixing mechanism 4 includes a fixing seat 41 and an elastic band 42; the fixing seat 41 is connected to the bottom of the lifting seat 34 through a spring seat 43, the fixing seat 41 is a regular hexagon, a locking pin 44 is fixedly connected to the side of the fixing seat 41, a locking head 45 is fixedly connected to the head of the locking pin 44, one end of the elastic band 42 is fixedly connected to the side of the fixing seat 41, and the other end of the elastic band 42 is fixedly connected to a fixing plate 46, the elastic band 42 and the locking pin 44 are arranged alternately, a through hole 47 is opened on the fixing plate 46, a locking groove 48 is opened on the side of the through hole 47 away from the elastic band 42, the diameter of the through hole 47 is larger than the diameter of the locking head 45, and the width of the locking groove 48 is larger than the diameter of the locking pin 44 and smaller than the diameter of the locking head 45.

[0069] like Fig.11 and 12 As shown, the fixing mechanism 4 is used to fix the crystal seed 401. The crystal seed 401 is placed under the fixing seat 41, and then the elastic band 42 is stretched through the fixing plate 46 to align the through hole 47 with the locking head 45. The fixing plate 46 is pressed to make it fit with the fixing seat 41, and then the fixing plate 46 is released, the elastic band 42 retracts, and the locking pin 44 enters the locking groove 48. Since the width of the locking groove 48 is greater than the diameter of the locking pin 44 and smaller than the diameter of the locking head 45, the fixing plate 46 can be prevented from falling off. Multiple elastic bands 42 can fix the crystal seed 401. When the crystal seed 401 is separated from the crystal in the stripping chamber 13, if the crystal seed 401 is damaged, the crystal seed 401 can be easily replaced.

[0070] Example 2

[0071] The stripping mechanism 5 includes a stripping motor 51 and a beating rod 52. The stripping motor 51 is fixedly connected to the bottom of the stripping chamber 13. The stripping motor 51 is provided with a vertically upward output shaft 53. The output shaft 53 is rotatably connected to the sliding plate 14. The beating rod 52 is symmetrically fixedly connected to the top of the output shaft 53. The height of the beating rod 52 is consistent with the fixed seat 41.

[0072] Furthermore, a pair of first metal sheets 54 are symmetrically fixed to the left side of the groove body of the translation rail 32, and a pair of second metal sheets 55 are symmetrically fixed to the middle part of the groove body of the translation rail 32. The translation seat 35 on the left side is made of metal. A second switch 56 is fixed to the front side of the box body 1, and also includes a second external power supply 57. One pole of the second external power supply 57 is electrically connected to one of the first metal sheets 54 and the second metal sheet 55. The other pole of the second external power supply 57 is electrically connected to one of the terminals of the two stripping motors 51 through the second switch 56. The other terminal of the stripping motor 51 on the left is electrically connected to the other first metal sheet 54, and the other terminal of the stripping motor 51 on the right is electrically connected to the other second metal sheet 55.

[0073] In this embodiment, Figure 8and 13 As shown, when the device is working, the second switch 56 is closed, when the left translation seat 35 is located in the middle, the two second metal sheets 55 are connected, and the stripping motor 51 on the right works; when the left translation seat 35 moves to the left, the two first metal sheets 54 are connected, and the stripping motor 51 on the left works. The stripping motor 51 drives the output shaft 53 and the beating rod 52 to rotate.

[0074] like Figure 4 As shown, when the device is working, when the seed crystal 401 on the right is located in the stripping chamber 13 on the right, the stripping motor 51 on the right works, and the fixing seat 41 on the right is struck by the beating rod 52. Since the fixing seat 41 is connected to the lifting seat 34 through the spring seat 43, the fixing seat 41 can vibrate, and the crystal on the seed crystal 401 falls off.

[0075] On the contrary, when the seed crystal 401 on the left is located in the stripping chamber 13 on the left, the stripping motor 51 on the left works, the fixing seat 41 vibrates, and the crystal on the seed crystal 401 falls off.

[0076] Example 3

[0077] A groove 71 is provided at the bottom of the front side plate of the box body 1 at a position corresponding to the precipitation chamber 12, a reverse osmosis membrane 72 is fixedly connected to the opening of the groove 71, and extrusion ports 73 are densely distributed on the box body 1 at positions corresponding to the groove 71. A cover shell 74 is fixedly connected to the front side of the box body 1, and the cover shell 74 covers the extrusion port 73 therein, a drain pipe 75 is fixedly connected to the top of the cover shell 74, a spring telescopic rod 76 is fixedly connected to the front side plate of the cover shell 74, a seat plate 77 is fixedly connected to the head of the spring telescopic rod 76, and a sealing column 78 corresponding to the extrusion port 73 is fixedly connected to the seat plate 77, a pressing plate 79 is sealingly and slidably connected in the precipitation chamber 12, a through hole 710 is provided on the pressing plate 79, and a vertical rod 711 is fixedly connected to the position of the through hole 710 at the bottom of the precipitation chamber 12, and the vertical rod 71 The diameter of 1 is consistent with the through hole 710, the inner wall of the partition 11 is fixedly connected with a guide rod 712, the pressure plate 79 is slidably connected to the guide rod 712, and a return spring 713 is sleeved on the guide rod 712 above the pressure plate 79. The two ends of the return spring 713 are respectively fixedly connected to the partition 11 and the pressure plate 79, and the third rotating shaft 714 is rotatably connected to the upper side of the pressure plate 79. A cam 715 is evenly fixedly connected to the third rotating shaft 714 in the longitudinal direction, and the cam 715 abuts against the pressure plate 79. A support plate 716 is fixedly connected to the rear side of the bracket plate 36 on the right side, and the second rotating shaft 310 is rotatably connected to the support plate 716. The rear ends of the third rotating shaft 714 and the second rotating shaft 310 are fixedly connected with a transmission wheel 717, and the two transmission wheels 717 are linked by a belt 718.

[0078] Furthermore, a liquid storage cylinder 81 is fixedly connected to the rear side of the box body 1, a liquid supply tube 82 is fixedly connected to the bottom of the liquid storage cylinder 81, the head of the liquid supply tube 82 is fixedly connected to the rear side plate of the box body 1, the connection position of the liquid supply tube 82 and the box body 1 is located at the upper left corner of the precipitation cavity 12, a floating frame 83 is fixedly connected to the inner wall of the box body 1, and a floating seat 84 is slidably connected inside the floating frame 83.

[0079] Furthermore, the drain pipe 75 passes through the heat dissipation fins 22 in a serpentine shape.

[0080] In this embodiment, as the amantadine hydrochloride in the solution precipitates, the concentration of the solution decreases, resulting in a slower rate of crystallization. To solve this problem, Figure 2 , 4 as well as Figure 14-18 As shown, the support plate 716 provided can improve the stability of the second rotating shaft 310. The second rotating shaft 310 drives the third rotating shaft 714 to rotate through the cooperation of the transmission wheel 717 and the belt 718, so that the cam 715 rotates. The cam 715 rotates synchronously with the turntable 33, that is, the cam 715 also rotates 180° intermittently. When the cam 715 rotates, the pressure plate 79 first descends and then rises under the action of the reset spring 713.

[0081] When the pressure plate 79 descends, when the vertical rod 711 enters the through hole 710, the through hole 710 is closed, and the pressure plate 79 descends to squeeze water out of the reverse osmosis membrane 72. Fig.14 As shown, as water is continuously squeezed out, the sealing column 78 will be squeezed out from the extrusion port 73, the water enters the cover 74, and is discharged from the drain pipe 75. When the pressure plate 79 rises, no water is squeezed out from the reverse osmosis membrane 72. Under the action of the spring telescopic rod 76, the seat plate 77 and the sealing column 78 are reset, and the sealing column 78 closes the extrusion port 73. When the pressure plate 79 rises, a negative pressure is formed below the pressure plate 79. When the through hole 710 is separated from the vertical rod 711, the liquid above the pressure plate 79 flows down through the through hole 710.

[0082] Since the two sides of the reverse osmosis membrane 72 are solution and water respectively, and since the density of the solution is relatively large, under natural conditions, water will enter the solution through the reverse osmosis membrane 72 to reduce the concentration of the solution. However, the sealing column 78 is provided to avoid this situation. When the pressure plate 79 is at a high point, crystals are precipitated. At this time, the sealing column 78 can block the extrusion port 73. When the pressure plate 79 descends, artificial pressure is applied to squeeze the water in the solution into the cover 74.

[0083] The extrusion of water from the solute will increase the concentration of the solution and increase the rate of crystallization. However, due to the extrusion of water, the amount of solution will decrease, so the solution needs to be replenished.

[0084] like Figure 2 , 4As shown in Figure 17, when the pressure plate 79 descends, the height of the solution in the precipitation chamber 12 decreases. At this time, the floating seat 84 descends to open the head of the liquid supply pipe 82, and the solution in the liquid storage cylinder 81 flows into the precipitation chamber 12 through the liquid supply pipe 82. When the pressure plate 79 moves to the highest point, the upper and lower sides of the pressure plate 79 are connected, and the solution continues to flow until the floating seat 84 blocks the liquid supply pipe 82.

[0085] like Figure 5 and 18 As shown, the water in the cover 74 is squeezed out from the precipitation chamber 12. Due to the cooling effect of the semiconductor refrigerator 2, the water in the cover 74 has a lower temperature. The low-temperature water passes through the heat dissipation fins 22 in a serpentine manner through the drain pipe 75, which can improve the heat dissipation effect of the hot end 202.

[0086] The working principle of the present invention is:

[0087] The seed crystal 401 is fixed to the bottom of the lifting seat 34 by the fixing mechanism 4, the precipitation chamber 12 is filled with a solution and cooled by the semiconductor refrigerator 2. In the initial state, the left and right seed crystals 401 are respectively located in the middle and the right side, and crystals are precipitated on the seed crystal 401 in the middle, and the stripping mechanism 5 on the right side works to cause the crystals on the seed crystal 401 on the right side to fall off.

[0088] Then the turntable 33 rotates 180°, the left and right seed crystals 401 are swapped, the seed crystal 401 on the right moves to the middle for crystal precipitation, the seed crystal 401 in the middle moves to the left stripping chamber 13, the stripping mechanism 5 on the left works to make the crystal on the seed crystal 401 on the left fall off, and then the turntable 33 rotates 180° again, the seed crystal 401 is swapped, and this cycle is repeated to achieve crystal precipitation and collection.

[0089] When the seed crystal 401 is replaced, the pressing plate 79 descends to squeeze out the water in the solution, thereby increasing the concentration of the solution, and the solution in the liquid storage cylinder 81 can be replenished into the precipitation chamber 12.

[0090] The preferred embodiments of the present invention disclosed above are only used to help explain the present invention. The preferred embodiments do not describe all the details in detail, nor do they limit the invention to only specific implementation methods. Obviously, many modifications and changes can be made according to the content of this specification. This specification selects and specifically describes these embodiments in order to better explain the principles and practical applications of the present invention, so that those skilled in the art can understand and use the present invention well. The present invention is limited only by the claims and their full scope and equivalents.

Claims

1. A cooling and precipitation device for producing amantadine hydrochloride, characterized in that: It includes a box body, a semiconductor refrigerator, a transfer mechanism, a fixing mechanism and a material removal mechanism; The box body is symmetrically fixed with partitions, which divide the box body into a precipitation chamber in the middle and material removal chambers on both sides. The material removal chamber is fixed with an inclined sliding plate, and the left and right side plates of the box body are provided with discharge ports at positions corresponding to the heads of the sliding plates. The bottom of the left partition is fixedly connected with a mounting frame, the semiconductor refrigerator is fixedly connected to the right side plate of the mounting frame, the semiconductor refrigerator includes a PN junction and a hot end and a cold end connected to the left and right sides of the PN junction, and the hot end is evenly fixedly connected with heat dissipation fins in the longitudinal direction; The transfer mechanism includes a lifting rail, a translation rail, a turntable, a lifting seat and a translation seat; the box body is symmetrically fixed with bracket plates, and a driving box is fixedly connected to the top of the bracket plate on the right side, the lifting rail is fixedly connected between the bracket plates, and positioning grooves are opened on both sides of the lifting rail. The lifting rail is "double-peaked", and the two peaks of the lifting rail are aligned with the partition plate. The translation rail is fixedly connected to the top of the lifting rail, and the first rotating shaft is rotatably connected to the top plate of the driving box. The turntable is fixedly connected to the top of the first rotating shaft, and the second rotating shaft is rotatably connected between the front and rear side plates of the driving box. The first rotating shaft and the second rotating shaft are linked by a bevel gear pair, and the transmission ratio of the first rotating shaft to the second rotating shaft is 1:

1. A self-locking motor is fixedly connected to the front side of the driving box. The machine is used to drive the second rotating shaft to rotate intermittently 180°, the lifting seat is slidably connected in the lifting track, and the front and rear sides of the lifting seat are fixedly connected with positioning pins, and the positioning pins are slidably connected in the positioning grooves. There are two lifting seats, and when one lifting seat is located in the middle of the precipitation chamber, the other lifting seat is located in the material removal chamber, and the translation seat is slidably connected in the translation track. The translation seat is located directly above the lifting seat, and a connecting rod is fixedly connected between the translation seats, and a suspension rod is fixedly connected below the translation seat, and the suspension rod is slidably connected to the lifting seat, and a first pin shaft is fixedly connected to the translation seat on the left side, and a second pin shaft is fixedly connected to the turntable, and a connecting rod is hinged between the first pin shaft and the second pin shaft, and the distance between the second pin shaft and the center of the turntable is equal to half of the distance between the two translation seats; The fixing mechanism is arranged below the lifting seat, and is used to fix the seed crystal; The stripping mechanism is arranged in the stripping cavity and is used to make the crystals precipitated on the seed crystals fall off.

2. A cooling and precipitation device for producing amantadine hydrochloride according to claim 1, characterized in that: A temperature sensor is fixedly connected to the bottom of the precipitation chamber, and a PLC controller and a first switch are fixedly connected to the front side of the box. The model of the PLC controller is STC15W201S. The PLC controller has a timer and a comparator. The power interface of the PLC controller is electrically connected to the first external power supply through the first switch, the temperature sensor is electrically connected to the signal input end of the PLC controller through the comparator, the control output end of the PLC controller is electrically connected to the semiconductor refrigerator, and the control output end of the PLC controller is also electrically connected to the self-locking motor through the timer. The PLC controller controls the intermittent rotation of the self-locking motor for a fixed period of time through the timer. Within the fixed period of time, the self-locking motor rotates 180°.

3. A cooling and precipitation device for producing amantadine hydrochloride according to claim 1, characterized in that: The fixing mechanism includes a fixing seat and an elastic band; the fixing seat is connected to the bottom of the lifting seat through a spring seat, the fixing seat is a regular hexagon, a locking pin is fixedly connected to the side of the fixing seat, a locking head is fixedly connected to the head of the locking pin, one end of the elastic band is fixedly connected to the side of the fixing seat, and the other end of the elastic band is fixedly connected to a fixing plate, the elastic band and the locking pin are arranged alternately, a through hole is provided on the fixing plate, a locking groove is provided on the side of the through hole away from the elastic band, the diameter of the through hole is larger than the diameter of the locking head, and the width of the locking groove is larger than the diameter of the locking pin and smaller than the diameter of the locking head.

4. A cooling and precipitation device for producing amantadine hydrochloride according to claim 3, characterized in that: The stripping mechanism includes a stripping motor and a beating rod. The stripping motor is fixed at the bottom of the stripping chamber. The stripping motor is provided with a vertically upward output shaft. The output shaft is rotatably connected to the sliding plate. The beating rod is symmetrically fixed at the top of the output shaft, and the height of the beating rod is consistent with the fixed seat.

5. A cooling and precipitation device for producing amantadine hydrochloride according to claim 4, characterized in that: A pair of first metal sheets are symmetrically fixed to the left side of the groove body of the translation track, and a pair of second metal sheets are symmetrically fixed to the middle part of the groove body of the translation track. The translation seat on the left is made of metal, and a second switch is fixed to the front side of the box body. It also includes a second external power supply. One pole of the second external power supply is electrically connected to one of the first metal sheets and the second metal sheet, and the other pole of the second external power supply is electrically connected to one of the terminals of the two stripping motors through the second switch. The other terminal of the stripping motor on the left is electrically connected to the other first metal sheet, and the other terminal of the stripping motor on the right is electrically connected to the other second metal sheet.

6. The cooling and precipitation device for producing amantadine hydrochloride according to claim 1, characterized in that: A groove is provided at the bottom of the front side plate of the box body corresponding to the position of the precipitation chamber, a reverse osmosis membrane is fixedly connected to the opening of the groove, extrusion ports are densely distributed at the positions corresponding to the grooves on the box body, a cover shell is fixedly connected to the front side of the box body, the cover shell covers the extrusion port therein, a drain pipe is fixedly connected to the top of the cover shell, a spring telescopic rod is fixedly connected to the front side plate of the cover shell, a seat plate is fixedly connected to the head of the spring telescopic rod, a sealing column corresponding to the extrusion port is fixedly connected to the seat plate, a pressure plate is sealingly and slidably connected in the precipitation chamber, a through hole is provided on the pressure plate, and a sealing column is fixedly connected to the bottom of the precipitation chamber corresponding to the through hole There is a vertical rod, the diameter of the vertical rod is consistent with the through hole, the inner wall of the partition is fixedly connected with a guide rod, the pressure plate is slidably connected to the guide rod, a return spring is sleeved on the guide rod above the pressure plate, the two ends of the return spring are respectively fixedly connected to the partition and the pressure plate, a third rotating shaft is rotatably connected above the pressure plate, a cam is evenly fixed on the third rotating shaft longitudinally, the cam abuts against the pressure plate, a support plate is fixedly connected to the rear side of the right bracket plate, the second rotating shaft is rotatably connected to the support plate, the third rotating shaft and the rear end of the second rotating shaft are fixedly connected with a transmission wheel, and the two transmission wheels are linked by belts.

7. A cooling and precipitation device for producing amantadine hydrochloride according to claim 6, characterized in that: A liquid storage cylinder is fixedly connected to the rear side of the box body, a liquid supply tube is fixedly connected to the bottom of the liquid storage tube, the head of the liquid supply tube is fixedly connected to the rear side plate of the box body, the connection position of the liquid supply tube and the box body is located at the upper left corner of the precipitation cavity, a floating frame is fixedly connected to the inner wall of the box body, and a floating seat is slidably connected inside the floating frame.

8. The cooling and precipitation device for producing amantadine hydrochloride according to claim 6, characterized in that: The drain pipe passes through the heat dissipation fins in a serpentine shape.

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