Trace target nucleic acid enrichment device based on porous plate

Abstract

The invention relates to the technical field of nucleic acid enrichment devices, and discloses a porous plate-based trace target nucleic acid enrichment device, which comprises a support plate, a porous support plate, an electric push rod and a rubber block, at least four supporting feet are vertically supported and fixed to the four corners of the bottom of the supporting plate, a bottom plate is fixed to the bottoms of the supporting feet, the porous carrying plate is arranged in the middle of the surface of the supporting plate, a plurality of inserting holes are evenly formed in the surface of the porous carrying plate, and the number of the electric push rods is the same as that of the inserting holes. An electric push rod is vertically mounted at the bottom of a support plate under each insertion hole of the porous support plate, a rubber block is fixed on a lifting rod at the top of the electric push rod and is arranged below the interior of the insertion hole, and the bottom of a placed test tube is supported on the surface of the rubber block; the test tube can be supported and jacked up in a mode that the electric push rod drives the rubber block to lift, and special tools such as a test tube clamp are not needed, so that operation is convenient.

Description

Technical Field

[0001] The invention relates to the technical field of nucleic acid enrichment devices, in particular to a trace target nucleic acid enrichment device based on a porous plate. Background Art

[0002] The enrichment of trace target nucleic acids is a method to increase the content of trace elements in nucleic acid samples. It is usually used in the fields of microbial detection and gene analysis. The enrichment process aims to collect the trace nucleic acids to be measured from a large amount of parent material to a smaller volume, thereby increasing their content to an analyzable level. The enrichment method may include the use of magnetic particle adsorption, co-precipitation enrichment method, foam flotation method and other technologies. The trace target nucleic acid enrichment method based on a porous plate is a commonly used nucleic acid enrichment method. By using the porous plate as a carrier, multiple samples can be placed, and then the enrichment of trace target nucleic acids can be completed by a robot or manually. During the enrichment process, it may be necessary to repeat the operation many times until the trace target nucleic acids adsorbed by the magnetic particles reach an analyzable amount. By adding a nucleic acid elution solution, the nucleic acids adsorbed on the magnetic particles are eluted to obtain an enriched nucleic acid sample.

[0003] The nucleic acid enrichment step is an important part of the nucleic acid extraction process. Nucleic acids are separated and purified from complex biological samples by specific methods. In this process, if the experimental design or process requires separate treatment of specific samples, or if there is an abnormality in a sample in a test tube (such as contamination, degradation, etc.), the test tube needs to be taken out separately for operation. Since the test tubes containing the samples are placed in different holes of the multi-well plate, special tools such as test tube clamps are required when taking them out, which makes the operation inconvenient. Therefore, we propose an enrichment device for trace target nucleic acids based on a multi-well plate. Summary of the invention

[0004] The purpose of the present invention is to provide an enrichment device for trace target nucleic acids based on a porous plate, wherein an electric push rod is vertically installed at the bottom of a support plate directly below each socket of the porous carrier plate, a rubber block is fixed on the lifting rod at the top and is placed below the inside of the socket, and the bottom of a placed test tube is supported on the surface of the rubber block. When it is necessary to take out the corresponding test tube separately for operation, the electric push rod can be used to drive the rubber block to rise and lift the test tube support, which facilitates operation without using special tools such as test tube clamps, thereby solving the problems raised in the background technology.

[0005] To achieve the above-mentioned purpose, the present invention provides the following technical solutions: a device for enriching trace target nucleic acids based on a porous plate, comprising a support plate, a porous carrier plate, an electric push rod and a rubber block; the four corners of the bottom of the support plate are vertically supported and fixed with support legs, at least four of which are provided, and a bottom plate is fixed at the bottom of the support legs; the porous carrier plate is placed in the middle of the surface of the support plate, and a plug hole is opened on the surface of the porous carrier plate, and a plurality of plug holes are evenly provided, and the plug holes are provided through the top and bottom; the number of the electric push rods is the same as the number of the plug holes, and the bottom of the support plate under each plug hole is vertically installed with an electric push rod, and a lifting rod is fixed on the extended end of the electric push rod, and the upper part of the lifting rod passes through the upper part of the upper plate and reaches the lower part of the inner part of the plug hole; the bottom of the rubber block is fixed with a rubber sleeve as a whole, and the top of each lifting rod is provided with a rubber block placed under the inner part of the plug hole, the diameter of the rubber block is smaller than the inner diameter of the plug hole, and the rubber block is fixed to the top of the lifting rod by means of the rubber sleeve being sleeved on the outer ring above the lifting rod.

[0006] By adopting the above technical solution, all the test tubes containing samples are placed in the sockets of the multi-porous carrier plate, and the bottoms are supported on the surface of the rubber block at the top of the electric push rod. When the nucleic acid enrichment operation is performed later, the electric push rod under the corresponding test tube can be controlled as needed to lift the lifting plate and the rubber block upward, thereby facilitating the corresponding test tube to be conveniently and regularly removed for related operations.

[0007] As a preferred embodiment of the present invention, an iron ring is fixed around the lower outer circle of the porous carrier plate, and a plurality of magnets are evenly embedded and fixed on the outer circle surface of the support plate. The porous carrier plate is adsorbed on the surface of the support plate by the magnets adsorbing the iron ring.

[0008] By adopting the above technical solution, the detachable arrangement of the porous carrier plate is achieved, and the porous carrier plate can be conveniently removed together with the rubber block for cleaning.

[0009] As a preferred embodiment of the present invention, a groove whose size is larger than the cross-sectional size of the porous carrier plate is opened on the support plate surface inside the magnet, and when the iron ring is adsorbed and placed on the support plate surface, the porous carrier plate portion below the iron ring is placed in the groove.

[0010] By adopting the above technical solution, when the porous carrier is placed, its bottom is placed in the groove and can be limited when placed.

[0011] As a preferred embodiment of the present invention, the upper outer ring of the lifting rod is surrounded by an external thread, and the inner ring of the rubber sleeve is provided with an internal thread adapted thereto, and the rubber sleeve is screwed onto the outer ring of the lifting rod by screwing the external thread and the internal thread together.

[0012] By adopting the above technical solution, the rubber sleeve can be detachably fixed to the top of the lifting rod by screwing. When the top of the lifting rod is screwed into the rubber sleeve to different degrees, the fixed height of the rubber block can be adjusted, which is convenient for adapting to test tubes of different lengths.

[0013] As a preferred embodiment of the present invention, a light board is fixed on the top of the porous carrier plate through a detachable structure, and a plurality of fill lights are evenly installed on the bottom of the light board, and their control switches are located on the upper surface of the light board.

[0014] By adopting the above technical solution, the fill light can be started to provide lighting fill light when needed.

[0015] As a preferred embodiment of the present invention, the detachable structure is a retractable rod body fixed under the side of the light board and a vertical block fixed on the side of the porous carrier plate. A rod hole is opened inside the vertical block, and the bottom of the retractable rod body is inserted into the rod hole to fix the light board.

[0016] By adopting the above technical solution, the lamp panel structure can be conveniently dismantled when not in use.

[0017] As a preferred embodiment of the present invention, the telescopic rod body is composed of a support tube and a support rod, the support rod is inserted into the support tube in a liftable manner, the support tube is inserted into the rod hole, and the support rod is fixed to the bottom of the light panel.

[0018] By adopting the above technical solution, the height of the lifting lamp panel when it is fixed can be adjusted, which makes it more convenient to use.

[0019] As a preferred embodiment of the present invention, a locking bolt is connected to the upper side of the support tube by screwing, and when the locking bolt is tightened, it penetrates into the support tube and contacts the surface of the support rod.

[0020] By adopting the above technical solution, when the support rod is placed inside the support tube and raised and lowered to adjust the light panel to different heights, the total length of the support rod and the support tube can be locked by tightening the locking bolt.

[0021] As a preferred embodiment of the present invention, an arc groove is formed on the upper surface of the rubber block, and the arc groove is located in the middle of the upper surface of the rubber block.

[0022] By adopting the above technical solution, the bottom of the test tube can be supported on the surface of the rubber block in a central position through the arc groove.

[0023] Compared with the prior art, the present invention has the following beneficial effects:

[0024] 1. The enrichment device for trace target nucleic acid based on a porous plate of the present invention has an electric push rod vertically installed at the bottom of the support plate directly below each socket of the porous carrier plate, a rubber block is fixed on the lifting rod at the top and is placed under the inside of the socket, and the bottom of the placed test tube is supported on the surface of the rubber block. When it is necessary to take out the corresponding test tube separately for operation, the electric push rod can be used to drive the rubber block to rise and lift the test tube support, which is convenient for operation without using special tools such as test tube clamps.

[0025] 2. The porous plate-based trace target nucleic acid enrichment device of the present invention is configured such that the rubber block and the rubber sleeve thereunder can be removed, and the porous carrier plate can also be removed, so that the porous carrier plate and the rubber block can be removed for cleaning when necessary.

[0026] 3. The device for enriching trace target nucleic acids based on a porous plate of the present invention has a rubber sleeve below the rubber block screwed onto a lifting rod above the electric push rod through a thread, and the connection height of the rubber block placed on the top of the electric push rod can be adjusted to facilitate the use of test tubes of different lengths.

[0027] 4. The trace target nucleic acid enrichment device based on a porous plate of the present invention is additionally provided with a lighting component placed above the side of the porous carrier plate to provide lighting when needed, and the lighting component can be removed, making it more flexible and convenient to use. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] Other features, objects and advantages of the present invention will become more apparent from the detailed description of non-limiting embodiments made with reference to the following drawings:

[0029] Figure 1 This is a schematic diagram of the overall structure of a first embodiment of a device for enriching trace target nucleic acids based on a multi-well plate according to the present invention;

[0030] Figure 2 This is a schematic diagram of the surface structure of a plate of an embodiment of the device for enriching trace target nucleic acids based on a multi-well plate of the present invention;

[0031] Figure 3 This is a schematic diagram of the surface structure of the support plate of Example 2 of the device for enriching trace target nucleic acids based on a porous plate of the present invention;

[0032] Figure 4 This is a schematic diagram of the structure of a porous carrier plate according to Embodiment 2 of the device for enriching trace target nucleic acids based on a porous plate of the present invention;

[0033] Figure 5 It is a schematic diagram of the side cross-sectional structure of a porous carrier plate of Example 2 of the device for enriching trace target nucleic acids based on a porous plate of the present invention;

[0034] Figure 6This is a schematic diagram of the connection structure between the rubber block and the lifting rod of Example 3 of the device for enriching trace target nucleic acids based on a porous plate of the present invention;

[0035] Figure 7 This is a schematic diagram of the structure of a multi-well support plate according to Embodiment 4 of the device for enriching trace target nucleic acids based on a multi-well plate of the present invention;

[0036] Figure 8 The schematic diagram of the bottom structure of the light board of the device for enriching trace target nucleic acid based on a porous plate of the present invention.

[0037] In the figure: 1. support plate; 11. support foot; 111. bottom plate; 12. groove; 13. magnet; 2. porous carrier plate; 21. socket; 22. iron ring; 23. vertical block; 231. rod hole; 3. electric push rod; 31. lifting rod; 311. external thread; 4. rubber block; 41. arc groove; 42. rubber sleeve; 5. light board; 51. support rod; 52. support tube; 521. locking bolt; 53. fill light. DETAILED DESCRIPTION

[0038] Embodiment 1

[0039] See also Figure 1 and Figure 2 The present invention provides a technical solution: a device for enriching trace target nucleic acids based on a porous plate, comprising a support plate 1, a porous carrier plate 2, an electric push rod 3 and a rubber block 4, wherein the four corners of the bottom of the support plate 1 are vertically supported and fixed with support legs 11, and the support legs 11 are at least four in number and have the same length, and a bottom plate 111 is fixed at the bottom of the support legs 11. When in use, the support legs 11 are supported and placed on a desktop through the bottom plate 111, so as to realize the lateral support and placement of the support plate 1.

[0040] The porous carrier plate 2 is placed in the middle of the surface of the support plate 1, and a socket 21 for inserting and placing a sample test tube is opened on the surface of the porous carrier plate 2. A plurality of sockets 21 are evenly arranged so that multiple groups of test tubes with samples can be placed. The sockets 21 are through-arranged from top to bottom, and the test tube is inserted into the inside of the sockets 21 from the upper opening.

[0041] The number of electric push rods 3 is the same as the number of sockets 21, and an electric push rod 3 is vertically installed at the bottom of the support plate 1 under each socket 21. A lifting rod 31 is fixed to the extended end of the electric push rod 3. The upper part of the lifting rod 31 passes through the upper part of the upper plate and extends from the opening at the bottom of the socket 21 to the lower part of the socket 21. The specifications of each electric push rod 3 are the same, and the specifications of the lifting rod 31 are also the same. The bottom of the rubber block 4 is fixed with a rubber sleeve 42 as a whole, and the top of each lifting rod 31 is provided with a rubber sleeve 42 placed in the socket 21. The rubber block 4 below the bottom part makes the number of rubber blocks 4 containing rubber sleeves 42 the same as the number of electric push rods 3. The diameter of the rubber block 4 is smaller than the inner diameter of the socket 21, and can be placed inside the socket 21 without touching the inner wall surface of the socket 21. The rubber block 4 is fixed to the top of the lifting rod 31 by the rubber sleeve 42 being sleeved on the outer ring above the lifting rod 31. The inner ring of the rubber sleeve 42 is tightly attached to the outer ring surface of the top of the lifting rod 31, so that the rubber block 4 can be detachably placed on the top of the lifting rod 31.

[0042] When in use, after the test tube is placed into the socket 21, its bottom support is in contact with the upper surface of the rubber block 4. In order to achieve the center of the bottom of the test tube in contact with the middle position of the surface of the rubber block 4, an arc groove 41 is opened on the upper surface of the rubber block 4. The arc groove 41 is located in the middle position of the upper surface of the rubber block 4, so that the bottom of the test tube can be in contact with the middle position of the surface of the rubber block 4 through the arc groove 41. When performing nucleic acid enrichment operations, if there is a need to take out the corresponding test tube for specific operations, all electric push rods 3 can be connected to the industrial control computer first, and the industrial control computer can be used to control the electric push rods 3 at the corresponding positions to drive the lifting rod 31 and the rubber block 4 on its top to rise, thereby supporting and lifting the test tube at the corresponding position upward, and the test tube can be easily taken out without using special tools such as test tube clamps.

[0043] Embodiment 2

[0044] See also Figure 3-5, under the premise that other structures remain the same as those in Example 1, the porous carrier plate 2 is placed on the top of the support plate 1 in a detachable manner, and in order to achieve relative stability during placement and prevent it from falling, a groove 12 is opened on the surface of the support plate 1, and the lifting rods 31 on the top of all the electric push rods 3 are distributed on the surface in the groove 12, and the size of the groove 12 is larger than the cross-sectional size of the porous carrier plate 2. When the porous carrier plate 2 is placed on the surface of the support plate 1, its lower part can be positioned in the groove 12, and a plurality of magnets 13 are evenly embedded and fixed on the surface of the support plate 1 on the outer circle of the groove 12, and an iron ring 22 is fixed around the outer circle below the porous carrier plate 2. When the bottom of the porous carrier plate 2 is placed in the groove 12, that is, the part of the porous carrier plate 2 below the iron ring 22 is placed in the groove 12, the iron ring 22 will support and touch the surface of the support plate 1, and the iron ring 22 can be adsorbed by the magnet 13 to achieve the purpose of adsorbing the porous carrier plate 2 on the surface of the support plate 1, and it is also convenient to remove the porous carrier plate 2 for cleaning later.

[0045] When the porous carrier plate 2 is taken away for cleaning, the rubber sleeve 42 can also be pulled out to remove the rubber block 4 so as to be taken away for cleaning.

[0046] Embodiment 3

[0047] See also Figure 6 Under the premise that other structures remain the same as those in the second embodiment, the upper outer ring of the lifting rod 31 is surrounded by an external thread 311, and the inner ring of the rubber sleeve 42 is provided with an internal thread adapted thereto, and the rubber sleeve 42 can be screwed on the outer ring of the lifting rod 31 by means of screwing and matching the external thread 311 with the internal thread, so that the rubber sleeve 42 can be screwed on the outer ring of the lifting rod 31, which can ensure that the rubber sleeve 42 and the rubber block 4 can be disassembled and removed. At the same time, when the lifting rod 31 is screwed into the rubber sleeve 42 to different depths, the height of the rubber block 4 placed below the inside of the jack 21 when it is screwed and fixed can be changed, so that test tubes of different heights can be adapted for use. When the test tube is relatively long, the rubber sleeve 42 below the rubber block 4 is screwed downward, and vice versa, when the test tube is relatively short, the rubber sleeve 42 below the rubber block 4 is screwed upward.

[0048] Embodiment 4

[0049] See also Figure 7 and Figure 8 Under the premise that other structures remain the same as those in Example 3, a light board 5 is arranged above the side of the porous carrier plate 2, and a plurality of fill-in lights 53 are evenly installed at the bottom of the light board 5. The control switch of the fill-in lights 53 is located on the upper surface of the light board 5. Therefore, when in use, the control switch of the fill-in lights 53 can be powered on, and the fill-in lights 53 can be started by the control switch to light them up and provide fill-in lighting.

[0050] A support rod 51 is vertically fixed to the lower side of the lamp board 5, and a support tube 52 is arranged at the lower side of the support rod 51. The lower side of the support rod 51 can be inserted into the upper inner part of the support tube 52. When the support rod 51 slides up and down in the support tube 52, the total length of the support rod 51 and the support tube 52 can be changed, and the light board 5 is supported by the support tube 52 and the support rod 51. When the lower side of the support rod 51 is raised and lowered inside the support tube 52, the support height of the light board 5 can be changed, and a locking bolt 521 is connected to the upper side of the support tube 52 by means of a screw connection. When the position of the lower side of the support rod 51 inside the support tube 52 is adjusted to the right position, the locking bolt 521 can be tightened so that its end passes through the support tube 52 and contacts the surface of the support rod 51, thereby locking the total length of the support rod 51 and the support tube 52, thereby locking the support height of the light board 5.

[0051] A vertical block 23 is fixed to the side of the porous carrier plate 2. The vertical block 23 is located above the iron ring 22, and a rod hole 231 is opened inside the vertical block 23. The size of the rod hole 231 is slightly larger than the outer diameter of the support tube 52. When in use, the bottom of the support tube 52 is inserted into the rod hole 231 and fixed, which can realize the support and fixation of the support tube 52 and the support rod 51, and the support and fixation of the light board 5. With this arrangement, when there is no need for fill light, the support tube 52 can be pulled out of the rod hole 231 of the vertical block 23, so that the support tube 52 and the structure above it and the light board 5 can be taken away together and stored without increasing the volume of the structure. In order to ensure stability during insertion and fixation, a plurality of rubber protrusions can be fixed on the inner wall of the rod hole 231 of the vertical block 23. When the support tube 52 is inserted, it can abut against the outer surface of the support tube 52, which has a certain anti-slip locking effect on the support tube 52.

[0052] When in use, the electric push rod 3 is connected to the industrial control computer, and the test tube containing the nucleic acid sample is inserted into different sockets 21 of the multi-porous carrier plate 2 and placed. The bottom of the test tube is supported on the surface of the rubber block 4 by the arc groove 41. Then, a multi-channel pipette gun operated manually or by a robot can be used to perform pipetting and other operations. A certain amount of crude nucleic acid extract or high-purity nucleic acid sample is injected into different test tubes, and then a magnetic particle suspension is added. A magnetic field is applied around the magnetic field generating device to adsorb the magnetic particles at the bottom of the reaction well, and the unbound liquid is removed at the same time. Then, the crude nucleic acid extract or high-purity nucleic acid sample in other test tubes can be quantitatively moved into the already entered well. In the test tube where the magnetic particles are adsorbed, the operation of magnetic particle adsorption and liquid removal is repeated. During the enrichment operation, a specific sample needs to be processed separately, or an abnormal situation (such as contamination, degradation, etc.) occurs in the sample in a test tube, and the test tube needs to be taken out separately for operation. The electric push rod 3 at the bottom of the test tube to be taken out can be controlled by the industrial control computer to drive the lifting rod 31 at the top to rise, and the rubber block 4 can be driven to rise through the rubber sleeve 42, so that the test tube at the corresponding position can be lifted up, which is convenient for the operator to take away the corresponding test tube and the sample loaded therein; after the enrichment operation is completed When the porous carrier plate 2 or the rubber block 4 needs to be cleaned, the porous carrier plate 2 can be taken upwards, and the rubber sleeve 42 can be pulled off from the lifting rod 31 to clean the porous carrier plate 2 and the rubber block 4. When the porous carrier plate 2 is placed again, the ring plate of the outer ring below it contacts the surface of the support plate 1 of the outer ring of the groove 12, and the ring plate is adsorbed by the magnet 13 to achieve the locking of the porous carrier plate 2; in addition, if the rubber block 4 is connected to the outer ring of the lifting rod 31 by screwing the rubber sleeve 42, the rotation of the rubber sleeve 42 can also adjust the height of the rubber block 4, so that it can provide a stable surface for the test tube at the bottom. The support requirements of the same height can meet the use of test tubes of different lengths; when better lighting conditions are needed, the support tube 52 can be inserted into the rod hole 231 of the vertical block 23, and the light board 5 is placed above the porous carrier plate 2. After the power supply line of the fill light 53 is connected to the power supply, the fill light 53 can be started by the switch to provide fill light. The support rod 51 can also be moved up and down in the support tube 52 by loosening the locking bolt 521 to change the height of the light board 5, and the locking bolt 521 can be tightened again to make its end contact with the outer surface of the support rod 51, locking the height of the light board 5 and the fill light 53 to meet the lighting fill light requirements in different situations.

Claims

1. A device for enriching trace target nucleic acids based on a multi-well plate, characterized in that: It comprises a support plate (1), a porous carrier plate (2), an electric push rod (3) and a rubber block (4); the four corners of the bottom of the support plate (1) are vertically supported and fixed with support feet (11), at least four support feet (11) are provided, and a bottom plate (111) is fixed at the bottom of the support feet (11); The porous carrier plate (2) is placed in the middle of the surface of the support plate (1), and a plug hole (21) is provided on the surface of the porous carrier plate (2). A plurality of the plug holes (21) are evenly arranged, and the plug holes (21) are arranged to penetrate from top to bottom. The number of the electric push rods (3) is the same as the number of the sockets (21), and an electric push rod (3) is vertically installed at the bottom of the support plate (1) below each socket (21), and a lifting rod (31) is fixed on the extended end of the electric push rod (3), and the upper part of the lifting rod (31) passes through the upper part of the upper plate and reaches the lower part of the socket (21); A rubber sleeve (42) is integrally fixed to the bottom of the rubber block (4), and a rubber block (4) is disposed at the top of each lifting rod (31) and is placed below the inside of the insertion hole (21). The diameter of the rubber block (4) is smaller than the inner diameter of the insertion hole (21), and the rubber block (4) is fixed to the top of the lifting rod (31) by means of the rubber sleeve (42) being sleeved on the outer ring above the lifting rod (31).

2. The device for enriching trace target nucleic acids based on a multi-well plate according to claim 1, characterized in that: An iron ring (22) is fixed around the lower outer ring of the porous carrier plate (2), and a plurality of magnets (13) are evenly embedded and fixed on the outer ring surface of the support plate (1). The purpose of adsorbing the porous carrier plate (2) to the surface of the support plate (1) is achieved by adsorbing the iron ring (22) with the magnets (13).

3. The device for enriching trace target nucleic acids based on a multi-well plate according to claim 2, characterized in that: The surface of the support plate (1) inside the magnet (13) is provided with a groove (12) whose size is larger than the cross-sectional size of the porous carrier plate (2); when the iron ring (22) is adsorbed and placed on the surface of the support plate (1), the part of the porous carrier plate (2) below the iron ring (22) is placed in the groove (12).

4. The device for enriching trace target nucleic acids based on a multi-well plate according to claim 1, characterized in that: The upper outer ring of the lifting rod (31) is surrounded by an external thread (311), and the inner ring of the rubber sleeve (42) is provided with an internal thread adapted thereto. The rubber sleeve (42) is screwed onto the outer ring of the lifting rod (31) by means of the screwing cooperation between the external thread (311) and the internal thread.

5. The device for enriching trace target nucleic acids based on a multi-well plate according to claim 1, characterized in that: A light board (5) is fixed on the top of the porous carrier plate (2) via a detachable structure, and a plurality of fill lights (53) are evenly mounted on the bottom of the light board (5), and a control switch thereof is located on the upper surface of the light board (5).

6. The device for enriching trace target nucleic acids based on a multi-well plate according to claim 5, characterized in that: The detachable structure comprises a telescopic rod body fixed below the side of the light board (5) and a vertical block (23) fixed on the side of the porous carrier plate (2); a rod hole (231) is provided inside the vertical block (23); the bottom of the telescopic rod body is inserted into the rod hole (231) to fix the light board (5).

7. The device for enriching trace target nucleic acids based on a multi-well plate according to claim 6, characterized in that: The telescopic rod body is composed of a support tube (52) and a support rod (51), the support rod (51) is inserted into the support tube (52) in a liftable manner, the support tube (52) is inserted into the rod hole (231), and the support rod (51) is fixed to the bottom of the light board (5).

8. The device for enriching trace target nucleic acids based on a multi-well plate according to claim 7, characterized in that: A locking bolt (521) is connected to the upper side of the support tube (52) by means of a screw connection. When the locking bolt (521) is tightened, it penetrates into the support tube (52) and contacts the surface of the support rod (51).

9. The device for enriching trace target nucleic acids based on a multi-well plate according to claim 1, characterized in that: An arc groove (41) is provided on the upper surface of the rubber block (4), and the arc groove (41) is located in the middle of the upper surface of the rubber block (4).

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