Composition with after-sun repairing and whitening effects and preparation method thereof

Abstract

The invention relates to the technical field of cosmetics, and particularly discloses a composition with after-sun repairing and whitening effects and a preparation method thereof. According to the present invention, various efficient components such as the ergothioneine compound, the acetylchitosamine, the nicotinamide, the sodium hyaluronate, the inositol, the aloe vera extract, the glycerophosphoinositide choline salt, the tetrahydromethylpyrimidine carboxylic acid, the oat beta-glucan compound, the citrus peel extract compound and the skin brightening agent are scientifically matched; according to the present invention, the excellent after-sun repairing and whitening effect is achieved, the comprehensive after-sun skin care is achieved, the skin state can be improved, and the skin health degree can be improved. The application creatively finds that when the glycerophosphoinositide choline salt, the citrus peel extract compound and the skin brightening agent are compounded, the effects of the composition in the aspects of after-sun repairing and whitening can be improved at the same time, and the comprehensive effect is relatively good.

Description

Technical Field

[0001] The present application relates to the technical field of cosmetics, and in particular to a composition having after-sun repair and whitening effects and a preparation method thereof. Background Art

[0002] With the increase of outdoor activities, the damage of ultraviolet rays to the skin is becoming more and more significant. When the skin is exposed to excessive ultraviolet rays, the enzyme tyrosinase in the skin becomes active, affecting the amino acid that becomes tyrosine and combining with it to form melanin. Under normal skin metabolism, melanin will be naturally excreted with the keratin metabolism, but when the skin is exposed to excessive ultraviolet rays, melanin will precipitate in large quantities, causing the skin to become dark and dull, and even forming spots and freckles. In addition, the skin often has problems such as redness, swelling, stinging, and peeling after sun exposure, and may cause long-term pigmentation and skin aging.

[0003] Therefore, there is an urgent need in the market for skin care products that can effectively repair sun damage, reduce melanin deposition, and brighten skin tone. Summary of the invention

[0004] The purpose of the present application is to overcome the deficiencies of the above-mentioned prior art and provide a composition with after-sun repair and whitening effects and a preparation method thereof. The composition of the present application has significant after-sun repair and whitening effects through scientific proportioning.

[0005] To achieve the above purpose, the technical solution adopted by this application is:

[0006] The present application provides a composition with after-sun repair and whitening effects, the composition comprising the following components:

[0007] Ergothioneine compound, acetyl glucosamine, niacinamide, sodium hyaluronate, inositol, aloe vera extract, glycerophosphoinositol choline salt, ectoine, oat beta-glucan compound, citrus peel extract compound and skin lightening agent;

[0008] The ergothioneine compound comprises ergothioneine, agaricus pine extract and mannitol;

[0009] The oat β-glucan compound comprises oat β-glucan, butylene glycol, 1,2-hexanediol, caprylyl glycol and water;

[0010] The citrus peel extract compound comprises citrus peel extract, butylene glycol and water;

[0011] The INCI name of the skin lightening agent is Arginine Ferulate / 1-Methylhydantoin-2-Imide / Cornus Officinalis Extract.

[0012] The composition with after-sun repair and whitening effects of the present application achieves excellent after-sun repair and whitening effects by scientifically proportioning a variety of high-efficiency ingredients such as ergothioneine compound, acetyl glucosamine, niacinamide, sodium hyaluronate, inositol, aloe vera extract, glycerophosphoinositol choline salt, tetrahydromethylpyrimidine carboxylic acid, oat β-glucan compound, citrus peel extract compound and skin lightening agent, and realizes comprehensive care for the skin after sun exposure, which can improve the skin condition and enhance the health of the skin.

[0013] The present application creatively discovered that when glycerophosphoinositol choline salt, citrus peel extract compound and skin lightening agent are compounded, the effect of the composition in after-sun repair and whitening can be improved at the same time. Adding glycerophosphoinositol choline salt to the composition has the effect of moisturizing and improving muscle and fat metabolism; adding citrus peel extract compound to the composition can avoid free radical damage to cells, help reduce the number of erythema after sun exposure, quickly repair damaged skin after sun exposure, effectively help reduce the number of erythema after sun exposure, and can also enhance the resistance of the skin, improve the skin environment, reduce the breeding of mites, and thus maintain the health of the skin. Adding a skin lightening agent to the composition can eliminate various free radicals, inhibit oxidation reactions and free radical reactions, and can combine with biological membrane phospholipids to protect membrane lipids from free radical damage to tissues, effectively inhibit the activity of tyrosinase, inhibit the phagocytosis of melanin by keratinocytes in the stratum corneum of the skin, prevent melanin from entering the stratum corneum of the skin, improve the transparency of skin tone, and brighten the skin color.

[0014] In addition, ergothioneine compound is added to the composition of the present application, and antioxidant ingredients such as ergothioneine can effectively neutralize free radicals, reduce ultraviolet damage, promote skin cell repair, and promote skin barrier repair; moisturizing components such as acetyl glucosamine and hyaluronic acid are added, which have the effects of moisturizing, soothing, and promoting skin barrier repair; whitening ingredients such as niacinamide are added to promote skin metabolism, reduce melanin deposition, and brighten skin color; inositol is added to have the effects of moisturizing, anti-oxidation, enhancing information exchange between skin cells, and promoting skin self-repair; aloe vera extract is added to have the effects of moisturizing, whitening and freckle removal, anti-aging, wound repair and anti-inflammatory healing; tetrahydromethylpyrimidine carboxylic acid is added to have the effects of whitening and anti-aging, and oat beta-glucan compound is added to have the effects of moisturizing, anti-aging, anti-allergic and anti-inflammatory, penetration, etc.

[0015] On the whole, the composition obtained by scientific formulation in the present application has significant after-sun repair and whitening effects.

[0016] As a preferred embodiment of the composition with after-sun repair and whitening effects described in the present application, the composition comprises the following components in parts by weight:

[0017] 0.2-1.5 parts of ergothioneine compound, 2-8 parts of acetyl glucosamine, 1-6 parts of niacinamide, 0.02-0.3 parts of sodium hyaluronate, 0.5-3.5 parts of inositol, 0.5-3 parts of aloe vera extract, 0.2-1 parts of glycerophosphoinositol choline salt, 0.5-3 parts of tetrahydromethylpyrimidine carboxylic acid, 0.1-1 parts of oat beta-glucan compound, 1-4 parts of citrus peel extract compound and 1-5 parts of skin lightening agent.

[0018] The present application prefers the above-mentioned components in parts by weight, which can better achieve after-sun repair and whitening effects.

[0019] As a preferred embodiment of the composition with after-sun repair and whitening effects described in the present application, the weight proportion of the glycerophosphoinositol choline salt is 0.3-0.7 parts, the weight proportion of the citrus peel extract compound is 1.5-2.5 parts, and the weight proportion of the skin lightening agent is 1.5-2.5 parts.

[0020] As a preferred embodiment of the composition with after-sun repair and whitening effects described in the present application, the weight proportion of the glycerophosphoinositol choline salt is 0.5 parts, the weight proportion of the citrus peel extract compound is 2 parts, and the weight proportion of the skin lightening agent is 2 parts.

[0021] The present application preferably synergistically compound the above-mentioned weight proportions of glycerophosphoinositol choline salt, citrus peel extract compound and skin lightening agent, and the obtained composition has excellent effects in after-sun repair and whitening.

[0022] As a preferred embodiment of the composition with after-sun repair and whitening effects described in the present application, the ergothioneine compound includes the following components in percentage by mass:

[0023] Ergothioneine 0.45-0.5%, Agaricus matsutake extract 5-15% and mannitol 84.45-94.5%;

[0024] The oat β-glucan compound comprises the following components in percentage by mass:

[0025] 0.9-1.1% oat beta-glucan, 5% butylene glycol, 2% 1,2-hexanediol, 0.3% caprylyl glycol and the balance water.

[0026] Preferably, the thioneine composite comprises the following components in mass percentage:

[0027] Ergothioneine 0.5%, Agaricus matsutake extract 15% and mannitol 84.5%;

[0028] The oat β-glucan compound comprises the following components in percentage by mass:

[0029] 1% oat β-glucan, 5% butylene glycol, 2% 1,2-hexanediol, 5% caprylyl glycol and the balance water.

[0030] Among them, the representative ergothioneine compound is F066-1, which includes the following components in percentage by mass: 0.5% of ergothioneine, 15% of Tricholoma matsutake extract and 84.5% of mannitol.

[0031] Among them, the representative glycerophosphoinositol choline salt is GPI CHOLINETM, and its INCI name is glycerophosphoinositol choline salt.

[0032] As a preferred embodiment of the composition with after-sun repair and whitening effects described in the present application, the citrus peel extract compound includes the following components in percentage by mass:

[0033] 1-5% citrus peel extract, 60-70% butylene glycol and the balance water;

[0034] The skin lightening agent comprises the following components in percentage by mass:

[0035] Arginine ferulate 2-6%, 1-methylhydantoin-2-imide 30-40%, Cornus officinalis extract 54-68%

[0036] Preferably, the citrus peel extract compound comprises the following components in percentage by mass:

[0037] 3% citrus peel extract, 67.9% butylene glycol and the balance water;

[0038] The skin lightening agent comprises the following components in percentage by mass:

[0039] Arginine ferulate 5%, 1-methylhydantoin-2-imide 35%, Cornus officinalis extract 60%.

[0040] Among them, the representative citrus peel extract compound is Mandarin Clear, which includes the following components in percentage by mass: 3% citrus peel extract, 67.9% butylene glycol and the remainder water.

[0041] A representative skin lightening agent is NB-835 deep skin lightening agent, which includes the following components in percentage by mass: 5% arginine ferulate, 35% 1-methylhydantoin-2-imide, and 60% cornus officinalis extract.

[0042] As a preferred embodiment of the composition with after-sun repair and whitening effects described in the present application, the composition further comprises at least one of a moisturizer, a thickener, an antioxidant and a chelating agent.

[0043] As a preferred embodiment of the composition with after-sun repair and whitening effects described in the present application, the moisturizer includes at least one of glycerin, 2,3-butylene glycol, saccharide isomers, panthenol and glyceryl polyether-26;

[0044] The thickener comprises at least one of hydroxyethyl acrylate / sodium acryloyldimethyltaurate copolymer, ammonium acryloyldimethyltaurate / VP copolymer and Sphingomonas fermentation product extract;

[0045] The antioxidant includes 1,2-hexanediol, or a mixture consisting of 0.7-1.3% of caprylhydroxamic acid, 10-14% of glycerol caprylate, and 84.7-89.3% of butanediol;

[0046] The chelating agent includes disodium EDTA.

[0047] The present application also provides a method for preparing the above-mentioned composition having after-sun repair and whitening effects, comprising the following steps:

[0048] S1, weighing the above components in parts by weight;

[0049] S2, adding a thickener and a chelating agent into an emulsifying pot, and homogenizing to form a mixture;

[0050] S3, add the moisturizer to the mixture, stir and heat to 80-85°C until the material is completely dissolved and transparent, keep warm for 15-25 minutes, and cool down to 40-45°C;

[0051] S4. Add antioxidants, ergothioneine compound, acetyl glucosamine, niacinamide, sodium hyaluronate, inositol, aloe vera extract, glycerophosphoinositol choline salt, tetrahydromethylpyrimidine carboxylic acid, oat β-glucan compound, citrus peel extract compound and skin lightening agent, stir evenly to obtain a composition with after-sun repair and whitening effects.

[0052] The present application provides a cosmetic, which comprises the above-mentioned composition with after-sun repair and whitening effects, and the mass percentage of the composition with after-sun repair and whitening effects in the cosmetic is 1-20%, preferably 8%.

[0053] Compared with the prior art, this application has the following beneficial effects:

[0054] The present application provides a composition with after-sun repair and whitening effects, and its preparation method and application. The present application achieves excellent after-sun repair and whitening effects by scientifically proportioning ergothioneine compound, acetyl glucosamine, niacinamide, sodium hyaluronate, inositol, aloe vera extract, glycerophosphoinositol choline salt, tetrahydromethylpyrimidine carboxylic acid, oat β-glucan compound, citrus peel extract compound and skin lightening agent and other high-efficiency ingredients, and achieves comprehensive care for after-sun skin, which can improve skin condition and enhance skin health. Among them, the present application creatively discovered that when glycerophosphoinositol choline salt, citrus peel extract compound and skin lightening agent are compounded, the effect of the composition in after-sun repair and whitening can be improved at the same time, and the comprehensive effect is better. DETAILED DESCRIPTION

[0055] In order to better illustrate the purpose, technical solutions and advantages of the present application, the present application will be further described below in conjunction with specific embodiments.

[0056] In this application, when it comes to numerical ranges, unless otherwise specified, the above numerical ranges are deemed to be continuous and include the minimum and maximum values ​​of the range, as well as each value between such minimum and maximum values. Further, when a range refers to an integer, each integer between the minimum and maximum values ​​of the range is included. In addition, when multiple ranges are provided to describe features or characteristics, the ranges can be merged. In other words, unless otherwise specified, all ranges disclosed herein should be understood to include any and all subranges included therein.

[0057] In the following examples and comparative examples, the experimental methods used are conventional methods unless otherwise specified, and the materials, reagents, etc. used are all commercially available unless otherwise specified, and the components and raw materials used in each parallel experiment are of the same type.

[0058] In the following examples and comparative examples:

[0059] Ergothioneine compound is F066-1, which includes the following components in percentage by mass: 0.5% ergothioneine, 15% matsutake extract and 84.5% mannitol, was purchased from Shanghai Ergothioneine Biotechnology Group Co., Ltd.

[0060] Glyceroinositol phosphate choline salt is GPI CHOLINETM, INCI name is glyceroinositol phosphate choline salt, purchased from Croda Chemicals (Shanghai) Co., Ltd.

[0061] The compound of citrus peel extract is MandarinClear transparent skin, which includes the following components in percentage by mass: 3% citrus peel extract, 67.9% butylene glycol and the balance water, purchased from Ichimaru Natural Beauty Co., Ltd. of Japan.

[0062] The skin lightening agent is NB-835 deep skin lightening agent, which includes the following components in percentage by mass: 5% arginine ferulate, 35% 1-methylhydantoin-2-imide, and 60% cornus officinalis extract, and is purchased from Guangdong Gexin Biotechnology Co., Ltd.

[0063] The oat β-glucan compound includes the following components in percentage by mass: 1% oat β-glucan, 5% butanediol, 2% 1,2-hexanediol, 5% caprylyl glycol and the balance water, and is purchased from Guangzhou Beta Health Biotechnology Co., Ltd.

[0064] Tetrahydromethylpyrimidine carboxylic acid was purchased from Merck, Germany; Aloe vera extract was purchased from Yunnan Wanlv Biological Co., Ltd.;

[0065] The thickener includes thickener 1, thickener 2 and thickener 3;

[0066] Thickener 1 is a mixture of hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, polysorbate-60 and sorbitan isostearate (the mass percentage of hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer is 88%, the mass percentage of polysorbate-60 is 6% and the mass percentage of sorbitan isostearate is 6%), purchased from Sepico (Shanghai) Special Cosmetics Co., Ltd.

[0067] Thickener 2 is ammonium acryloyldimethyltaurate / VP copolymer, which is sourced from Clariant Chemical Technology (Shanghai) Co., Ltd.; thickener 3 is a Sphingomonas fermentation product extract purchased from Lubrizol Corporation of the United States.

[0068] NAGO AB91 is composed of caprylhydroxamic acid, caprylic glycerol and butanediol (the mass percentage of caprylhydroxamic acid is 12%, the mass percentage of caprylic glycerol is 1% and the mass percentage of butanediol is 87%), and was purchased from Guangzhou Aizhuo Biotechnology Co., Ltd.

[0069] Neyeahn INS includes 60% by weight of carbohydrate isomers, 3% by weight of lactobionic acid and 37% by weight of water, and was purchased from Zhongke Houpu (Guangzhou) Technology Development Co., Ltd.

[0070] Examples 1-5

[0071] Examples 1-5 provide a composition with after-sun repair and whitening effects, and its components and their mass percentages (%) are shown in Table 1.

[0072] The preparation method of the composition having after-sun repair and whitening effects comprises the following steps:

[0073] S1, weighing the above components in parts by weight;

[0074] S2, adding thickener 1-3 and disodium EDTA into an emulsifying pot, and homogenizing to form a mixture;

[0075] S3, add glycerin, 2,3-butylene glycol, panthenol and glyceryl polyether-26 to the mixture, stir and heat to 85°C until the material is completely dissolved and transparent, keep warm for 20 minutes, and cool to 40-45°C;

[0076] S4. Add NAGO AB91, 1,2-hexanediol, ergothioneine compound, acetyl glucosamine, niacinamide, sodium hyaluronate, inositol, aloe vera extract, glycerophosphoinositol choline salt, tetrahydromethylpyrimidine carboxylic acid, oat β-glucan compound, citrus peel extract compound and skin lightening agent, stir evenly to obtain a composition with after-sun repair and whitening effects.

[0077] Table 1

[0078]

[0079]

[0080] Comparative Examples 1-10

[0081] Comparative Examples 1-10 provide a composition with after-sun repair and whitening effects, and its components and their mass percentages (%) are shown in Table 2.

[0082] The preparation methods of the compositions with after-sun repair and whitening effects provided in Comparative Examples 1-10 are similar to those of Examples 1-5.

[0083] Table 2

[0084]

[0085]

[0086]

[0087] Test Example 1: DPPH free radical scavenging rate test

[0088] Take 2 mL of each of the compositions with after-sun repair and whitening effects prepared in Examples 1-5 and Comparative Examples 1-10, and mix with 8 mL of 1×10 -4 mol / L DPPH-ethanol solution, shaken evenly, and placed in a dark place at 25°C to react for 30 minutes to obtain a mixed solution, which was then placed in a centrifuge and centrifuged at 7000 rpm for 5 minutes. The supernatant after centrifugation was taken and the absorbance A1 was measured at a wavelength of 517 nm.

[0089] Take 2 mL of anhydrous ethanol and perform the same operation to measure the absorbance A2; take 2 mL of deionized water and perform the same operation to measure the absorbance A3; take 2 mL of 1 mg / mL vitamin C solution as a positive control, set up 3 parallel experiments in each group to calculate the average value, and calculate the free radical scavenging ability of different combinations of compositions according to the DPPH scavenging rate formula. The test results are shown in Table 3 below:

[0090] DPPH clearance rate = [1-(A1-A2) / A3] × 100%

[0091] Table 3

[0092]

[0093]

[0094] It can be seen from Table 3 above that, compared with Comparative Examples 1-14, the compositions with after-sun repair and whitening effects prepared in Examples 1-5 have higher DPPH radical scavenging rates, all reaching more than 30%, among which Example 5 is the best example, and the composition has the highest DPPH radical scavenging rate.

[0095] In Comparative Examples 1 to 6, due to the lack of one or two of the raw material components (glycerophosphoinositol choline salt, skin lightening agent and citrus peel extract compound), the prepared compositions with after-sun repair and whitening effects have a low DPPH radical scavenging rate, which illustrates that the composition using the formula of the present application has a higher DPPH radical scavenging rate.

[0096] Comparative Examples 7-10 add a small amount or an excess of glycerophosphoinositol choline salt, a skin lightening agent and a citrus peel extract compound, and the DPPH radical scavenging rate of the composition is lower than that of Examples 1-5, indicating that the content of the components also has a great influence on the DPPH radical scavenging rate of the composition.

[0097] Test Example 2: Testing of Facial Brightness L* Value and ITA° Value

[0098] 150 healthy women aged 20 to 45 were selected and randomly divided into 15 groups, 10 people in each group. After cleaning their faces, they sat quietly for 30 minutes in a constant temperature and humidity environment (temperature 21±1°C, relative humidity 50±10%). Each group used the compositions of Examples 1-5 and Comparative Examples 1-14 for 5 minutes each and then removed. The L* value and ITA° value of the skin were detected using a CK skin tester and a VISIA skin tester. The test time was immediately after cleaning the skin (initial value), immediately after removal, 10 minutes, 30 minutes and 4 hours. The higher the L* value, the brighter the skin, and the larger the ITA° value, the lighter the skin color. The average value of each group was recorded and calculated. The test results are shown in Table 4 below:

[0099] Table 4

[0100]

[0101]

[0102] It can be seen from Table 4 above that compared with Comparative Examples 1-14, the ΔL* value change rate and ΔITA° value of the composition with after-sun repair and whitening effects prepared in Examples 1-5 are significantly increased, while in the composition of Comparative Examples 1-6, due to the lack of one or two of the raw material components (glycerophosphoinositol choline salt, skin lightening agent and citrus peel extract compound), the ΔL* value change rate and ΔITA° value of the prepared composition with after-sun repair and whitening effects are not significantly increased, which illustrates that the composition with after-sun repair and whitening effects of the present application has a significant instant whitening and brightening effect.

[0103] Comparing Examples 1-5 and Comparative Examples 7-10, the △L* value change rate and △ITA° value of the skin increased significantly, but the higher the content of each component, the better the effect. Among them, the △L* value change rate and △ITA° value of the skin in Example 5 increased most significantly, which shows that Example 5 is the best combination and can achieve the best whitening and lightening effect.

[0104] Test Example 3: Moisturizing Test - Transepidermal Water Loss Test

[0105] Test method: The moisture content of the facial skin of the subjects was measured before and after using the product (a composition with after-sun repair and whitening effects). The moisture content of the facial skin was measured using a transepidermal water loss meter Vapometer (model: SWL5201, Delfin, Finland). The test used TEWL parameters to compare the skin moisture loss before and after the product use.

[0106] Where △TEWL=(TEWL1-TEWL2) / TEWL1×100%, TEWL1 is the test value before using the product, TEWL2 is the test value after using the product, and the larger the △TEWL value, the greater the reduction in transepidermal water loss of the test skin after using the product, and the better the barrier repair and moisturizing effect of the product. The average value of each group was recorded and calculated, and the results are shown in Table 5 below.

[0107] Table 5

[0108] Group <![CDATA[TEWL1]]> <![CDATA[TEWL2]]> △TEWL(%) Example 1 19.95 12.03 39.70 Example 2 20.08 12.05 39.99 Example 3 20.54 12.01 41.53 Example 4 20.23 12.05 40.43 Example 5 21.03 12.13 42.32 Comparative Example 1 13.30 9.23 30.60 Comparative Example 2 12.45 8.88 28.67 Comparative Example 3 12.36 9.01 27.10 Comparative Example 4 10.22 7.59 25.73 Comparative Example 5 10.31 7.76 24.73 Comparative Example 6 11.07 8.28 25.20 Comparative Example 7 15.44 10.18 34.07 Comparative Example 8 16.04 10.46 34.78 Comparative Example 9 15.93 9.86 38.10 Comparative Example 10 16.47 10.67 35.21

[0109] It can be seen from Table 5 above that, compared with Comparative Examples 1-14, the ΔTEWL data of the compositions with after-sun repair and whitening effects prepared in Examples 1-5 all reached more than 39%, while the compositions of Comparative Examples 1-6 lacked one or two of the raw material components (glycerophosphoinositol choline salt, skin lightening agent and citrus peel extract compound), and the ΔTEWL of the compositions with after-sun repair and whitening effects prepared was lower, which shows that the formula of the composition with after-sun repair and whitening effects of the present application has significant moisturizing effect, among which the composition of Example 5 has the highest transepidermal moisture retention rate and is the best embodiment.

[0110] The contents of the compound of glycerophosphoinositol choline salt, skin lightening agent and citrus peel extract in Comparative Examples 7-10 vary, and the higher the content of the components, the better the effect. The △TEWL of the prepared composition with after-sun repair and whitening effects is low, which is lower than that of the composition of Examples 1-5.

[0111] Test Example 4: Tyrosinase Activity Inhibition Test

[0112] 0.025 g of the composition with after-sun repair and whitening effects of Examples 1-5 and Comparative Examples 1-14 were respectively placed in test tubes, 120 μL of phosphate buffer solution and 40 μL of 2.98 mmol / L tyrosine solution (2.98 mmol / L tyrosine solution was used as a substrate) were added to the test tubes respectively, and the mixed solution in the test tubes was added to a 96-well plate in equal amounts, and 40 μL of 200 U / mL tyrosinase solution was added to each well after being kept constant at 37° C. in a water bath for 10 min, and the mixture was mixed at room temperature and protected from light. After being bathed in a water bath at 37° C. for 15 min, the mixture was quickly placed in a multifunctional microplate reader, and the absorbance at 475 nm was measured to calculate the tyrosinase inhibition rate. The above operation was repeated for 3 times in parallel. The test results are shown in Table 6:

[0113] Table 6

[0114]

[0115]

[0116] It can be seen from Table 6 above that, compared with Comparative Examples 1-14, the compositions with after-sun repair and whitening effects prepared in Examples 1-5 have higher inhibition rates on tyrosinase, all reaching more than 50%. The composition of Example 5 has the highest inhibition rate on tyrosinase, which indicates that Example 5 is the best combination.

[0117] Since the compositions of Comparative Examples 1-6 lack one or two of the raw material components (glycerophosphoinositol choline salt, skin lightening agent and citrus peel extract compound), the inhibition rate of the prepared composition with after-sun repair and whitening effects on tyrosinase is low, indicating that the composition with after-sun repair and whitening effects of the present application has a high inhibitory effect on tyrosinase activity; the content of glycerophosphoinositol choline salt, skin lightening agent and citrus peel extract compound in Comparative Examples 7-10 changes, and the higher the content of the components, the better the effect. The inhibition rate of tyrosinase in the prepared composition with after-sun repair and whitening effects is not as good as that of the composition of Examples 1-5.

[0118] Test Example 5: Safety Test - Patch Test

[0119] The compositions with after-sun repair and whitening effects prepared in the above Examples 1-5 were subjected to human safety patch tests, and the test method referred to the human skin patch test in the "2015 Cosmetic Safety Technical Specifications".

[0120] The method of skin occlusion patch test is: select 30 people aged 18-60 years old, and select an area not exceeding 50mm 2 , a qualified spot test device with a depth of about 1mm, take 0.020mL of the above example and put it into the small chamber of the spot tester, apply the spot tester to the curved side of the subject's forearm with a low-allergenic tape, and gently press it with the palm of your hand to evenly apply it to the skin for 24 hours. Observe the skin reaction according to the standards in the table below 0.5h after removal (after the indentation disappears), 24h and 48h, and record the observation results.

[0121] The grading standards for skin reactions in the skin occlusive patch test are shown in Table 7.

[0122] Table 7

[0123]

[0124]

[0125] The results are shown in Table 8.

[0126] Table 8

[0127] Group 0.5h 24h 48h Overall results Example 1 0 0 0 All 30 people had no positive reaction Example 2 0 0 0 All 30 people had no positive reaction Example 3 0 0 0 All 30 people had no positive reaction Example 4 0 0 0 All 30 people had no positive reaction Example 5 0 0 0 All 30 people had no positive reaction

[0128] As can be seen from Table 8, the patch test results of the compositions with after-sun repair and whitening effects prepared in Examples 1-5 are all negative, indicating that the compositions prepared in the present application are mild and non-irritating and will not cause adverse skin reactions to this batch of subjects.

[0129] Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present application rather than to limit the scope of protection of the present application. Although the present application has been described in detail with reference to the preferred embodiments, ordinary technicians in this field should understand that the technical solution of the present application can be modified or replaced by equivalents without departing from the essence and scope of the technical solution of the present application.

Claims

1. A composition having after-sun repair and whitening effects, characterized in that: The composition comprises the following components: Ergothioneine compound, acetyl glucosamine, niacinamide, sodium hyaluronate, inositol, aloe vera extract, glycerophosphoinositol choline salt, ectoine, oat beta-glucan compound, citrus peel extract compound and skin lightening agent; The ergothioneine compound comprises ergothioneine, agaricus pine extract and mannitol; The oat β-glucan compound comprises oat β-glucan, butylene glycol, 1,2-hexanediol, caprylyl glycol and water; The citrus peel extract compound comprises citrus peel extract, butylene glycol and water; The INCI name of the skin lightening agent is Arginine Ferulate / 1-Methylhydantoin-2-Imide / Cornus Officinalis Extract.

2. The composition with after-sun repair and whitening effects as claimed in claim 1, characterized in that: The composition comprises the following components in parts by weight: 0.2-1.5 parts of ergothioneine compound, 2-8 parts of acetyl glucosamine, 1-6 parts of niacinamide, 0.02-0.3 parts of sodium hyaluronate, 0.5-3.5 parts of inositol, 0.5-3 parts of aloe vera extract, 0.2-1 parts of glycerophosphoinositol choline salt, 0.5-3 parts of tetrahydromethylpyrimidine carboxylic acid, 0.1-1 parts of oat beta-glucan compound, 1-4 parts of citrus peel extract compound and 1-5 parts of skin lightening agent.

3. The composition with after-sun repair and whitening effects as claimed in claim 2, characterized in that: The weight proportion of the glycerophosphoinositol choline salt is 0.3-0.7 parts, the weight proportion of the citrus peel extract compound is 1.5-2.5 parts, and the weight proportion of the skin lightening agent is 1.5-2.5 parts.

4. The composition with after-sun repair and whitening effects as claimed in claim 2, characterized in that: The weight proportion of the glycerophosphoinositol choline salt is 0.5 parts, the weight proportion of the citrus peel extract compound is 2 parts, and the weight proportion of the skin lightening agent is 2 parts.

5. The composition with after-sun repair and whitening effects as claimed in claim 1, characterized in that: The ergothioneine composite comprises the following components in percentage by weight: Ergothioneine 0.45-0.5%, Agaricus matsutake extract 5-15% and mannitol 84.45-94.5%; The oat β-glucan compound comprises the following components in percentage by mass: 0.9-1.1% oat beta-glucan, 5% butylene glycol, 2% 1,2-hexanediol, 0.3% caprylyl glycol and the balance water.

6. The composition with after-sun repair and whitening effects as claimed in claim 1, characterized in that: The citrus peel extract compound comprises the following components in percentage by mass: 1-5% citrus peel extract, 60-70% butylene glycol and the balance water; The skin lightening agent comprises the following components in percentage by mass: Arginine ferulate 2-6%, 1-methylhydantoin-2-imide 30-40%, Cornus officinalis extract 54-68%.

7. The composition with after-sun repair and whitening effects as claimed in claim 1, characterized in that: The composition further comprises at least one of a humectant, a thickener, an antioxidant and a chelating agent.

8. The composition with after-sun repair and whitening effects as claimed in claim 7, characterized in that: The moisturizing agent includes at least one of glycerin, 2,3-butylene glycol, saccharide isomers, panthenol and glyceryl polyether-26; The thickener comprises at least one of hydroxyethyl acrylate / sodium acryloyldimethyltaurate copolymer, ammonium acryloyldimethyltaurate / VP copolymer and Sphingomonas fermentation product extract; The antioxidant includes 1,2-hexanediol, or a mixture consisting of 0.7-1.3% of caprylhydroxamic acid, 10-14% of glycerol caprylate, and 84.7-89.3% of butanediol; The chelating agent includes disodium EDTA.

9. A method for preparing a composition having after-sun repair and whitening effects as claimed in any one of claims 1 to 8, characterized in that: The following steps are involved: S1, weighing the above components in parts by weight; S2, adding a thickener and a chelating agent into an emulsifying pot, and homogenizing to form a mixture; S3, add the moisturizer to the mixture, stir and heat to 80-85°C until the material is completely dissolved and transparent, keep warm for 15-25 minutes, and cool down to 40-45°C; S4. Add antioxidants, ergothioneine compound, acetyl glucosamine, niacinamide, sodium hyaluronate, inositol, aloe vera extract, glycerophosphoinositol choline salt, tetrahydromethylpyrimidine carboxylic acid, oat β-glucan compound, citrus peel extract compound and skin lightening agent, stir evenly to obtain a composition with after-sun repair and whitening effects.

10. A cosmetic, characterized in that: The cosmetic comprises the composition with after-sun repairing and whitening effects as claimed in any one of claims 1 to 8, and the mass percentage of the composition with after-sun repairing and whitening effects in the cosmetic is 1-20%.

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