Anti-aging nutritious food based on 2-oxoglutaric acid and application

Abstract

The invention discloses an anti-aging nutritional food based on 2-oxoglutaric acid and application, the 2-oxoglutaric acid is reasonably proportioned with natural components such as sorbitol, maltodextrin, gamma-aminobutyric acid GABA, PS composite nervonic acid 50% and the like, a synergistic effect is exerted, and the aging process is effectively delayed. The 2-oxoglutaric acid not only has a remarkable anti-oxidation effect, but also can remove free radicals, relieve oxidative stress, enhance energy metabolism of mitochondria, improve energy supply of cells and delay cell decline. In addition, 50% of gamma-aminobutyric acid and PS composite nervonic acid in the formula are beneficial to improving neurological functions and relieving chronic inflammation, so that various physiological problems in the aging process are comprehensively resisted, and the overall health level is improved. In addition, by optimizing the production process, the bioavailability of the key components is improved, and the stability and the lasting effect of the key components in vivo are ensured.

Description

Technical Field

[0001] The present invention relates to the technical field of medical and nutritional food, and in particular to an anti-aging nutritional food based on 2-oxoglutaric acid and its application. Background Art

[0002] With the increase in the average life expectancy of human beings and the improvement of health awareness, anti-aging and physical fitness have become the focus of public attention. Aging is a complex biological process, the main characteristics of which include oxidative stress, mitochondrial dysfunction, enhanced inflammatory response and decreased immune system function. These factors together lead to cell damage, tissue degeneration and systemic functional decline; 2-Oxoglutarate (α-ketoglutarate, referred to as AKG) is an important intermediate metabolite of the tricarboxylic acid cycle and is widely present in human cells. Studies have shown that AKG has a significant effect in delaying aging and improving health. Antioxidant effect: It protects cells from damage by reducing oxidative stress levels and removing free radicals; Enhanced mitochondrial function: Improves the efficiency of cell energy metabolism and delays mitochondrial dysfunction caused by aging; Anti-inflammatory effect: Reduce the release of inflammatory mediators and reduce the damage of chronic inflammation to the body.

[0003] Although AKG has important anti-aging functions, it is easily degraded by heat, moisture and oxygen during storage and processing, resulting in reduced functional activity; secondly, AKG is rapidly metabolized in the gastrointestinal tract and has a limited duration of action, making it difficult to achieve a lasting anti-aging effect; and using AKG alone is difficult to fully cope with the aging process driven by multiple factors, such as decreased immune function and decreased neuronal function; based on this, an anti-aging nutritional food and application based on 2-oxoglutaric acid is needed. Summary of the invention

[0004] To achieve the above object, the present invention provides the following solution: an anti-aging nutritional food based on 2-oxoglutaric acid, the nutritional food comprising the following components, and the weight proportion of each component is as follows: 2-Oxoglutaric acid AKG: 28-32 parts; Sorbitol: 14-16 parts; Maltodextrin: 13-15 parts; Gamma-aminobutyric acid GABA: 4.5-5.5 parts; PS composite nervonic acid 50%: 5.5-6.5 parts; Giant salamander peptide: 4.5-5.5 parts; L-arginine: 4.5-5.5 parts; Hydroxypropyl methylcellulose: 4.5-5.5 parts; Noni enzyme powder: 4.5-5.5 parts; EGCG: 2.5-3.5 parts; Astragalus extract: 2.5-3.5 parts; Rehmannia root extract: 2.5-3.5 parts; Magnesium stearate: 0.8-1.2 parts; Vitamin B1: 0.08-0.12 parts; Vitamin B2: 0.08-0.12 parts.

[0005] Further preferably, the purity of the γ-aminobutyric acid GABA is above 99%, and the γ-aminobutyric acid used meets the food grade or pharmacopoeia grade standards, and the source of the γ-aminobutyric acid is extracted from natural plants.

[0006] Further preferably, the PS complex neuraminic acid 50% includes a neuraminic acid component complex of phosphatidylserine and neuraminic acid, phosphatidylcholine, phosphatidylcholine and ceramide, wherein the content of phosphatidylserine in the complex is not less than 50%.

[0007] Further preferably, the giant salamander peptide is a bioactive peptide extracted from giant salamander, containing at least 50% high concentration of collagen peptide, the extract is subjected to ultrasonic extraction, the ultrasonic extraction method uses a water-soluble solvent and is carried out at a temperature of 40-60°C, the extraction time is 1-3 hours, and the purity of the collagen peptide is ensured to be ≥85% by high performance liquid chromatography HPLC.

[0008] Further preferably, the astragalus extract is total astragaloside extracted from the root of astragalus, and its astragaloside content is ≥70%, the extraction process adopts solvent extraction method, the solvent is ethanol-water mixed solvent, the extraction temperature is 50-60°C, the extraction time is 2-4 hours, and the quality control is carried out by high performance liquid chromatography HPLC after extraction.

[0009] The present invention also provides an anti-aging nutritious food based on 2-oxoglutaric acid, the preparation of the nutritious food comprising: S1. Weigh the weight of each raw material according to the formula components; S2. Add 2-oxoglutaric acid AKG, sorbitol, maltodextrin and γ-aminobutyric acid GABA basic ingredients according to the proportion into a clean stirring container, use a high shear mixer for preliminary mixing, set the stirring speed to 200-500 rpm, and the mixing time lasts for 15-20 minutes; S3, adding 50% PS composite nervonic acid, giant salamander peptide, L-arginine and hydroxypropyl methylcellulose to the preliminary mixture in S2, and continuing to mix using a high shear mixer, setting the mixing speed to 200-500 rpm, and mixing for 15-20 minutes to obtain a basic mixture; S4, add noni enzyme powder, magnesium stearate, EGCG, astragalus extract, rehmannia extract, vitamin B1 and vitamin B2 to the basic mixture of S3 in proportion, continue to stir evenly in the mixer, control the stirring speed at 100-300rpm, control the temperature at 20-25°C, maintain the humidity at 40%-60%, and mix for 15-25 minutes to obtain a final mixture; S5, sending the final mixture after uniform mixing into a twin-screw granulator, adding a wetting agent in batches, wherein the wetting agent is water or physiological saline, the granulation temperature is controlled at 30-50° C., and the size of the granules after granulation is 0.5-1.5 mm; The granulated particles are dried and then compressed into tablets or filled into capsules.

[0010] Further preferably, the amount of the wetting agent added is controlled at 5%-10% of the mass of the final mixture, and the addition rate of the wetting agent is controlled at 2-5 g / min.

[0011] Further preferably, the final mixture needs to be sieved before entering the twin-screw granulator, the sieve aperture is 0.5-1.0 mm, the sieving operation duration is 5-10 minutes, and the sieving speed is 30-50 rpm.

[0012] In addition, the present invention also provides an application of an anti-aging nutritional food based on 2-oxoglutaric acid, wherein the nutritional food is used to improve human endurance, relieve post-exercise fatigue and delay aging.

[0013] According to the specific embodiments provided by the present invention, the present invention discloses the following technical effects: 1. The present invention effectively exerts synergistic effects and delays the aging process by combining 2-oxoglutaric acid with sorbitol, maltodextrin, γ-aminobutyric acid, and 50% of PS composite nervonic acid natural ingredients. 2-oxoglutaric acid has a significant antioxidant effect, can scavenge free radicals, and reduce oxidative stress. At the same time, it improves the mitochondrial energy metabolism efficiency, enhances the energy supply of cells, and delays the decline of cell function caused by aging. In addition, the γ-aminobutyric acid and 50% of PS composite nervonic acid in the present invention can further combat various physiological problems in the aging process and improve the overall health level by improving nerve function and reducing chronic inflammatory reactions. 2. The present invention can slow down the oxidative stress, mitochondrial function decline and inflammatory response occurring in the aging process by increasing the synergistic effect of ingredients such as 2-oxoglutaric acid, γ-aminobutyric acid, 50% PS composite neuraminic acid, and giant salamander peptide, thereby effectively improving cell vitality and delaying the aging process. At the same time, the natural plant ingredients of EGCG, astragalus extract and rehmannia extract in the formula further enhance the body's antioxidant capacity for the immune system, and help resist the negative impact of the external environment on the human body. The nutritional ingredients of the present invention improve the bioavailability of key ingredients through optimized production processes and reasonable ingredient ratios, ensure their stability and lasting effects in the body, and better play the comprehensive benefits of anti-aging, improving physical fitness and relieving post-exercise fatigue. BRIEF DESCRIPTION OF THE DRAWINGS

[0014] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0015] Figure 1 The figure is a process flow chart of the nutritional food of the present invention. DETAILED DESCRIPTION

[0016] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0017] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, the present invention is further described in detail below with reference to the accompanying drawings and specific embodiments.

[0018] Example 1 This embodiment describes an anti-aging nutritional food based on 2-oxoglutaric acid, wherein the total amount of ingredients added to the food is 1000 mg, and the amount of each ingredient added is proportioned according to the following ratios: Ingredients (total amount: 1000 mg): S1: Weigh the weight of each raw material according to the formula composition; S2: Add the basic ingredients of 2-oxoglutaric acid (300 mg), sorbitol (150 mg), maltodextrin (138 mg) and γ-aminobutyric acid (50 mg) into a clean mixing container according to the proportion, and use a LFM-1000 high shear mixer for preliminary mixing, setting the stirring speed to 300 rpm and the mixing time to 15 minutes; S3: Add 50% (60 mg) of PS complex nervonic acid, 50 mg of giant salamander peptide, 50 mg of L-arginine and 50 mg of hydroxypropyl methylcellulose to the preliminary mixture in S2, and continue to mix using a high shear mixer at a speed of 250 rpm for 20 minutes to obtain a basic mixture; S4: adding noni enzyme powder (50 mg), magnesium stearate (10 mg), EGCG (30 mg), astragalus extract (30 mg), rehmannia extract (30 mg), vitamin B1 (1 mg) and vitamin B2 (1 mg) to the basic mixture of S3, controlling the stirring speed at 300 rpm, continuing to stir evenly in the mixer, controlling the temperature at 25°C, maintaining the humidity at 45%, and mixing for 24 minutes to obtain a final mixture; S5: Granulation: The final mixture is transferred to a twin-screw granulator, and a wetting agent is added. The amount of the wetting agent is controlled to be 8% of the final mixture mass. The wetting agent is physiological saline. Granulation is performed by the granulator. The granulation temperature is controlled at 40°C and the time is set to 30 minutes. The size of the granules after granulation is 0.5-1.0 mm. The granulated material was dried with the drying temperature set at 40°C, the humidity at 50%, and the drying time at 2 hours. The dried granules were compressed using a tablet press with the compression pressure set at 15 MPa to ensure that the tablets were dense and stable.

[0019] In this embodiment, before the final mixture S4 enters the twin-screw granulator, it is screened, the screen aperture is 0.5 mm, the screening operation duration is 5 minutes, and the screening speed is set to 30 rpm to ensure that the particle size of the final mixture is uniform.

[0020] Example 2 This embodiment describes an anti-aging nutritional food based on 2-oxoglutaric acid, wherein the total amount of ingredients added to the food is 1000 mg, and the amount of each ingredient added is proportioned according to the following ratios: Ingredients (total amount: 1000 mg): S1: Weigh the weight of each raw material according to the formula composition; S2: Add the basic ingredients of 2-oxoglutaric acid (285 mg), sorbitol (155 mg), maltodextrin (138 mg) and γ-aminobutyric acid (47 mg) into a clean mixing container according to the ratio; Use LFM-1000 high shear mixer for preliminary mixing. Set the stirring speed to 300 rpm and the mixing time to 17 minutes; S3: Add active ingredients of PS complex nervonic acid 50% (58 mg), giant salamander peptide (52 mg), L-arginine (53 mg) and hydroxypropyl methylcellulose (45 mg) to the preliminary mixture in S2; Continue mixing using a high shear mixer, set the speed to 280 rpm, and mix for 20 minutes; S4: Add noni enzyme powder (50 mg), magnesium stearate (12 mg), EGCG (33 mg), astragalus extract (35 mg), rehmannia extract (35 mg), vitamin B1 (1 mg) and vitamin B2 (1 mg) to the basic mixture of S3, and continue mixing. The stirring speed is controlled at 230 rpm, the temperature is controlled at 22°C, and the humidity is maintained at 49%. Ensure that these ingredients are evenly distributed in the mixture. The mixing time lasts for 19 minutes to obtain a final mixture. S5: Granulation: The final mixture is transferred to a twin-screw granulator, and a wetting agent is added. The amount of the wetting agent added is controlled to be 8% of the final mixture mass. The wetting agent is water. Granulation is performed by a granulator. The granulation temperature is controlled at 45°C and the time is set to 30 minutes. The size of the particles after granulation is 0.5-1.0 mm.

[0021] The granulated material is dried at a temperature of 40°C, a humidity of 50%, and a drying time of 2 hours to ensure that the granules do not stick together and reach a dryness suitable for tableting. The dried granules are tableted using a tablet press with a tableting pressure set to 15 MPa to ensure that the tablets are dense and stable.

[0022] In this embodiment, before the S4 final mixture enters the twin-screw granulator, it is screened, the screen mesh size is 0.6 mm, the screening operation duration is 6 minutes, and the screening speed is set to 36 rpm to ensure that the particle size of the final mixture is uniform.

[0023] Embodiment 3: This embodiment describes an anti-aging nutritional food based on 2-oxoglutaric acid, wherein the total amount of ingredients added to the food is 1000 mg, and the amount of each ingredient added is proportioned according to the following ratios: Ingredients (total amount: 1000 mg): S1: Weigh the weight of each raw material according to the formula composition; S2: Add the basic ingredients of 2-oxoglutaric acid (300 mg), sorbitol (148 mg), maltodextrin (140 mg) and γ-aminobutyric acid (50 mg) into a clean mixing container according to the proportions; Use LFM-1000 high shear mixer for preliminary mixing, set the stirring speed to 300 rpm, and the mixing time to 18 minutes; S3: Add PS complex nervonic acid 50% (58 mg), giant salamander peptide (48 mg), L-arginine (52 mg) and hydroxypropyl methylcellulose (50 mg) to the preliminary mixture in S2; Continue to use the high shear mixer to mix, set the speed to 350 rpm, and continue mixing for 20 minutes to obtain a basic mixture; S4: adding noni enzyme powder (50 mg), magnesium stearate (10 mg), EGCG (28 mg), astragalus extract (32 mg), rehmannia extract (32 mg), vitamin B1 (1 mg) and vitamin B2 (1 mg) to the basic mixture of S3, controlling the stirring speed at 240 rpm, continuing to stir evenly in the mixer, controlling the temperature at 25°C, maintaining the humidity at 58%, and mixing for 20 minutes to obtain a final mixture; S5: Granulation: The final mixture is transferred to a twin-screw granulator, and a wetting agent is added. The amount of the wetting agent is controlled to be 6% of the final mixture mass. The wetting agent is water. Granulation is performed by the granulator. The granulation temperature is controlled at 40°C and the time is set to 30 minutes. The size of the granules after granulation is 0.5-1.0 mm. The granulated material is dried at a temperature of 40°C, a humidity of 50%, and a drying time of 2 hours to ensure that the particles do not stick together and reach a dryness suitable for tableting; The dried granules were compressed using a tablet press with the compression pressure set at 15 mPa to ensure that the tablets were dense and stable.

[0024] In this embodiment, before the S4 final mixture enters the twin-screw granulator, it is screened, the screen aperture is 0.7 mm, the screening operation duration is 7 minutes, and the screening speed is set to 39 rpm to ensure that the particle size of the final mixture is uniform.

[0025] Embodiment 4: This embodiment describes an anti-aging nutritional food based on 2-oxoglutaric acid, wherein the total amount of ingredients added to the food is 1000 mg, and the amount of each ingredient added is proportioned according to the following ratios: Ingredients (total amount: 1000 mg): S1: Weigh the weight of each raw material according to the formula composition; S2: Add the basic ingredients of 2-oxoglutaric acid (310 mg), sorbitol (152 mg), maltodextrin (135 mg) and γ-aminobutyric acid (48 mg) into a clean mixing container according to the ratio; Use LFM-1000 high shear mixer for preliminary mixing. Set the stirring speed to 300 rpm and the mixing time to 19 minutes to ensure that the ingredients are evenly dispersed; S3: Add active ingredients of PS complex nervonic acid 50% (55 mg), giant salamander peptide (50 mg), L-arginine (50 mg) and hydroxypropyl methylcellulose (48 mg) to the preliminary mixture in S2; Continue mixing using the high shear mixer at a speed of 220 rpm to obtain a base mixture; S4: adding noni enzyme powder (52 mg), magnesium stearate (10 mg), EGCG (32 mg), astragalus extract (28 mg), rehmannia extract (28 mg), vitamin B1 (1 mg) and vitamin B2 (1 mg) to the basic mixture of S3, controlling the stirring speed at 190 rpm, continuing to stir evenly in the mixer, controlling the temperature at 25°C, maintaining the humidity at 40%, and mixing for 25 minutes to obtain a final mixture; S5: Granulation: The mixed material is transferred to a twin-screw granulator, and a wetting agent is added. The amount of the wetting agent is controlled to be 6% of the final mixture mass. The wetting agent is water. Granulation is performed by the granulator. The temperature is controlled at 40°C, the time is set to 30 minutes, and the particle diameter is controlled to be 0.5-1.0 mm. The granulated material is dried at a temperature of 40°C, a humidity of 50%, and a drying time of 2 hours to ensure that the particles do not stick together and reach a dryness suitable for tableting; The dried granules were compressed using a tablet press with the compression pressure set at 15 mPa to ensure that the tablets were dense and stable.

[0026] In this embodiment, before the S4 final mixture enters the twin-screw granulator, it is screened, the screen mesh size is 0.9 mm, the screening operation duration is 8 minutes, and the screening speed is set to 45 rpm to ensure that the particle size of the final mixture is uniform.

[0027] Embodiment 5: This embodiment describes an anti-aging nutritional food based on 2-oxoglutaric acid, wherein the total amount of ingredients added to the food is 1000 mg, and the amount of each ingredient added is proportioned according to the following ratios: Ingredients (total amount: 1000 mg): S1: Weigh the weight of each raw material according to the formula composition; S2: Add the basic ingredients of 2-oxoglutaric acid (320 mg), sorbitol (140 mg), maltodextrin (135 mg) and γ-aminobutyric acid (45 mg) into a clean mixing container according to the proportions; Use LFM-1000 high shear mixer for preliminary mixing, set the stirring speed to 280 rpm, and the mixing time to 18 minutes to ensure that the ingredients are evenly dispersed; S3: Add active ingredients of PS complex nervonic acid 50% (55 mg), giant salamander peptide (55 mg), L-arginine (50 mg) and hydroxypropyl methylcellulose (45 mg) to the preliminary mixture in S2; Continue to mix using the high shear mixer, set the speed to 250 rpm, and the mixing time to 20 minutes to obtain a base mixture; S4: add noni enzyme powder (48 mg), magnesium stearate (10 mg), EGCG (33 mg), astragalus extract (32 mg), rehmannia extract (30 mg), vitamin B1 (1 mg) and vitamin B2 (1 mg) to the basic mixture of S3, control the stirring speed at 300 rpm, continue to stir evenly in the mixer, control the temperature at 25°C, maintain the humidity at 52%, and mix for 20 minutes to obtain a final mixture; S5: Granulation: The final mixture is transferred to a twin-screw granulator, and a wetting agent is added. The amount of the wetting agent added is controlled at 7% of the final mixture mass. The wetting agent is physiological saline. Granulation is performed by a granulator. The temperature is controlled at 38°C, the time is set to 25 minutes, and the particle diameter is controlled at 0.5-1.0 mm.

[0028] The granulated material is dried at a temperature of 38°C, a humidity of 55%, and a drying time of 2 hours to ensure that the particles do not stick together and reach a dryness suitable for tableting; The dried granules were compressed using a tablet press with the compression pressure set at 14 mPa to ensure that the tablets were dense and stable.

[0029] In this embodiment, before the S4 final mixture enters the twin-screw granulator, it is screened, the screen aperture is 0.8 mm, the screening operation duration is 10 minutes, and the screening speed is set to 47 rpm to ensure that the particle size of the final mixture is uniform.

[0030] Embodiment 6: This embodiment describes an anti-aging nutritional food based on 2-oxoglutaric acid, using a non-integer precise ingredient ratio, wherein the total ingredient addition amount of the food is 1000 mg, and the addition amount of each ingredient is proportioned according to the following ratio; Ingredients (total amount: 1000 mg): S1: Weigh the weight of each raw material according to the formula composition; S2: Add 2-oxoglutaric acid (310.5 mg), sorbitol (150 mg), maltodextrin (132.2 mg) and γ-aminobutyric acid (50.1 mg) into a clean stirring container according to the ratio; Use LFM-1000 high shear mixer for preliminary mixing, set the stirring speed to 300 rpm, and the mixing time to 15 minutes; S3: Add active ingredients of PS complex nervonic acid 50% (55.7 mg), giant salamander peptide (49.6 mg), L-arginine (50.8 mg) and hydroxypropyl methylcellulose (47.5 mg) to the preliminary mixture in S2; Use the same high shear mixer, set the speed to 250 rpm, and mix for 20 minutes to ensure that all ingredients are fully blended to obtain a base mixture; S4: adding noni enzyme powder (52.6 mg), magnesium stearate (10.2 mg), EGCG (30.3 mg), astragalus extract (28.7 mg), rehmannia extract (29.8 mg), vitamin B1 (1 mg) and vitamin B2 (1 mg) to the basic mixture of S3, controlling the stirring speed at 300 rpm, continuing to stir evenly in the mixer, controlling the temperature at 25°C, maintaining the humidity at 45%, and mixing for 22 minutes to obtain a final mixture; Step 5: Granulation: The final mixture is transferred to a twin-screw granulator, and a wetting agent is added. The amount of the wetting agent is controlled to be 8.5% of the final mixture mass. The wetting agent is water. Granulation is performed by a granulator. The granulation temperature is controlled at 38°C for 25 minutes. The particle diameter is controlled to be 0.5-1.0 mm. The granulated material is dried at a temperature of 40°C, a humidity of 50%, and a drying time of 2 hours to ensure that the particles do not stick together and reach a dryness suitable for tableting; The dried granules are compressed into tablets using a tablet press, and the compression pressure is set to 14 mPa to ensure the density and stability of the tablets.

[0031] In this embodiment, before the S4 final mixture enters the twin-screw granulator, it is screened, the screen mesh diameter is 1.0 mm, the screening operation duration is 9 minutes, and the screening speed is set to 50 rpm to ensure that the particle size of the final mixture is uniform.

[0032] In this embodiment, the sources of the remaining components of the nutritional food are as follows: 2-Oxoglutarate AKG is produced by microbial fermentation, wherein Bacillus strains or Escherichia coli are used as the bacterial species, and fermentation is carried out in a specific culture medium (the carbon source is glucose), and the fermentation broth is centrifuged, purified by ion exchange resin and spray dried to meet food grade standards; Sorbitol is prepared by catalytic hydrogenation of corn or cassava starch, using a nickel-based catalyst to catalyze the reaction to obtain food-grade sorbitol; Maltodextrin, commercial food-grade maltodextrin, is made by partial hydrolysis of corn starch, tapioca starch or wheat starch by enzymatic hydrolysis, with a molecular weight between 1000-3000, meeting food-grade standards; γ-aminobutyric acid GABA is extracted from natural plants, obtained through ultrafiltration purification and freeze-drying after fermentation, and meets food grade or pharmacopoeia grade standards; PS complex neuraminic acid 50%, including phosphatidylserine and neuraminic acid, phosphatidylcholine, phosphatidylcholine and ceramide neuraminic acid component complex, wherein the content of phosphatidylserine in the complex is not less than 50%; The giant salamander peptide is a bioactive peptide extracted from the giant salamander, containing at least 50% high-concentration collagen peptide. The extract is extracted by ultrasonic extraction, which uses a water-soluble solvent and is carried out at a temperature of 40-60° C. The extraction time is 1-3 hours. The purity of the collagen peptide is ensured to be ≥85% by high-performance liquid chromatography HPLC detection; Hydroxypropyl methylcellulose is extracted from natural plant cellulose, treated with sodium hydroxide solution and etherified with propylene glycol, and meets food grade standards; Noni enzyme powder is fermented from fresh Noni fruit, dried at low temperature and powdered to ensure the activity of its main ingredients. The astragalus extract is the total astragaloside extracted from the root of astragalus, and its astragaloside content is ≥70%. The extraction process adopts a solvent extraction method, the solvent is an ethanol-water mixed solvent, the extraction temperature is 50-60°C, the extraction time is 2-4 hours, and the quality control is performed by high performance liquid chromatography HPLC after extraction; The Rehmannia root extract is a total glycoside component extracted from the root of Rehmannia root. The Rehmannia root extract is extracted from the fresh Rehmannia root by using an ethanol-water mixed solvent, the extraction temperature is 50-60° C., the extraction time is 2-4 hours, and then the purity is detected by high performance liquid chromatography HPLC, and the Rehmannia root extract is separated and purified by column chromatography to obtain the Rehmannia root extract; EGCG, the active ingredient extracted from green tea, was extracted using a water-ethanol mixed solvent, and the extract was freeze-dried to obtain EGCG; L-arginine is prepared by microbial fermentation, using Corynebacterium glutamicum as the fermentation strain, glucose as the carbon source during the fermentation process, the fermentation broth is centrifuged to remove impurities, then purified by ion exchange resin to remove impure substances, and finally spray dried to obtain dry powder, the final product meets food grade standards; Magnesium stearate, produced by reacting stearic acid with magnesium oxide in a reactor to produce magnesium stearate, which meets food grade standards; Vitamin B1 is prepared by microbial fermentation. Microorganisms such as Klebsiella intestinalis are often used as fermentation strains. Their ability to synthesize vitamin B1 is utilized. During the fermentation process, glucose or other simple sugars are used as carbon sources. The fermentation broth is extracted, purified and crystallized to obtain high-purity vitamin B1 that meets food grade standards. Vitamin B2 is prepared by microbial fermentation. The commonly used strain is riboflavin fungus, which can synthesize a large amount of riboflavin during the fermentation process. After fermentation, the product liquid is separated and spray-dried to finally obtain food-grade vitamin B2 powder, which meets the food additive standards.

[0033] The present invention forms a synergistic anti-aging nutritional combination by rationally mixing 2-oxoglutaric acid with sorbitol, maltodextrin, γ-aminobutyric acid, 50% PS composite nervonic acid, and giant salamander peptide. 2-oxoglutaric acid plays a key antioxidant role in the present invention, can effectively remove free radicals, reduce oxidative stress, and improve mitochondrial energy metabolism efficiency, delaying the common mitochondrial function decline problem in the aging process. By introducing 50% of γ-aminobutyric acid GABA and PS complex neuraminic acid, it can effectively improve nerve function, reduce chronic inflammatory response, and fight against the degeneration of nerve cell function during the aging process. The natural plant ingredients of Astragalus extract and Rehmannia extract enhance the antioxidant capacity of the immune system.

[0034] The technical features of the above embodiments may be combined arbitrarily. To make the description concise, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0035] The principles and implementation methods of the present invention are described in this article using specific examples. The description of the above embodiments is only used to help understand the method and core idea of ​​the present invention. At the same time, for those skilled in the art, according to the idea of ​​the present invention, there will be changes in the specific implementation methods and application scope. In summary, the content of this specification should not be understood as limiting the present invention.

Claims

1. An anti-aging nutritional food based on 2-oxoglutaric acid, characterized in that: The nutritional food comprises the following components, and the weight proportion of each component is as follows: 2-Oxoglutaric acid AKG: 28-32 parts; Sorbitol: 14-16 parts; Maltodextrin: 13-15 parts; Gamma-aminobutyric acid GABA: 4.5-5.5 parts; PS composite nervonic acid 50%: 5.5-6.5 parts; Giant salamander peptide: 4.5-5.5 parts; L-arginine: 4.5-5.5 parts; Hydroxypropyl methylcellulose: 4.5-5.5 parts; Noni enzyme powder: 4.5-5.5 parts; EGCG: 2.5-3.5 parts; Astragalus extract: 2.5-3.5 parts; Rehmannia root extract: 2.5-3.5 parts; Magnesium stearate: 0.8-1.2 parts; Vitamin B1: 0.08-0.12 parts; Vitamin B2: 0.08-0.12 parts.

2. The anti-aging nutritional food based on 2-oxoglutaric acid according to claim 1, characterized in that: The purity of the gamma-aminobutyric acid GABA is above 99%, and the gamma-aminobutyric acid used meets the food grade or pharmacopoeia grade standards. The gamma-aminobutyric acid is extracted from natural plants.

3. The anti-aging nutritional food based on 2-oxoglutaric acid according to claim 1, characterized in that: The PS complex neuraminic acid 50% comprises a neuraminic acid component complex of phosphatidylserine and neuraminic acid, phosphatidylcholine, phosphatidylcholine and ceramide, wherein the content of phosphatidylserine in the complex is not less than 50%.

4. The anti-aging nutritional food based on 2-oxoglutaric acid according to claim 1, characterized in that: The giant salamander peptide is a bioactive peptide extracted from the giant salamander, containing at least 50% high-concentration collagen peptides. The extract is subjected to ultrasonic extraction, and the ultrasonic extraction method uses a water-soluble solvent and is carried out at a temperature of 40-60°C. The extraction time is 1-3 hours. The purity of the collagen peptide is ensured to be ≥85% by high-performance liquid chromatography HPLC detection.

5. The anti-aging nutritional food based on 2-oxoglutaric acid according to claim 1, characterized in that: The astragalus extract is the total astragaloside extracted from the root of astragalus, and its astragaloside content is ≥70%. The extraction process adopts a solvent extraction method, the solvent is an ethanol-water mixed solvent, the extraction temperature is 50-60°C, the extraction time is 2-4 hours, and the quality control is carried out by high performance liquid chromatography HPLC after extraction.

6. An anti-aging nutritional food based on 2-oxoglutaric acid according to any one of claims 1 to 5, characterized in that: The nutritious food preparation comprises: S1. Weigh the weight of each raw material according to the formula components; S2. Add 2-oxoglutaric acid AKG, sorbitol, maltodextrin and γ-aminobutyric acid GABA basic ingredients according to the proportion into a clean stirring container, use a high shear mixer for preliminary mixing, set the stirring speed to 200-500 rpm, and the mixing time lasts for 15-20 minutes; S3, adding 50% PS composite nervonic acid, giant salamander peptide, L-arginine and hydroxypropyl methylcellulose to the preliminary mixture in S2, and continuing to mix using a high shear mixer, setting the mixing speed to 200-500 rpm, and mixing for 15-20 minutes to obtain a basic mixture; S4, add noni enzyme powder, magnesium stearate, EGCG, astragalus extract, rehmannia extract, vitamin B1 and vitamin B2 to the basic mixture of S3 in proportion, continue to stir evenly in the mixer, control the stirring speed at 100-300rpm, control the temperature at 20-25°C, maintain the humidity at 40%-60%, and mix for 15-25 minutes to obtain a final mixture; S5, sending the final mixture after uniform mixing into a twin-screw granulator, adding a wetting agent, wherein the wetting agent is water or physiological saline, and the granulation temperature is controlled at 30-50° C. The size of the granules after granulation is 0.5-1.5 mm; The granulated particles are dried and then compressed into tablets or filled into capsules.

7. The anti-aging nutritional food based on 2-oxoglutaric acid according to claim 6, characterized in that: The amount of the wetting agent added is controlled at 5%-10% of the final mixture mass, and the adding speed of the wetting agent is controlled at 2-5 g / min.

8. The anti-aging nutritional food based on 2-oxoglutaric acid according to claim 6, characterized in that: The final mixture needs to be sieved before entering the twin-screw granulator. The sieve aperture is 0.5-1.0 mm, the sieving operation duration is 5-10 minutes, and the sieving speed is 30-50 rpm.

9. The use of an anti-aging nutritional food based on 2-oxoglutaric acid according to any one of claims 1 to 8, characterized in that: The nutritious food is used for improving human endurance, relieving fatigue after exercise and delaying aging.

Images