Preparation method of nano-silver medical wound self-adhesive dressing patch

Abstract

The invention discloses a preparation method of a nano-silver medical wound self-adhesion dressing patch. The preparation method comprises the following steps: step (1), preparing biological protein fiber cloth; (2) soaking biological protein fiber cloth with a nano-silver solution, and drying to obtain nano-silver biological protein fiber cloth; (3) the nano-silver biological protein fiber cloth and the water-absorbing fiber cloth are subjected to composite rolling cutting, and a moisture-absorbing physiotherapy chip layer is obtained; and (4) assembling and packaging the moisture absorption physiotherapy chip layer, the adhesive tape layer and the protective film layer to obtain the nano-silver medical wound self-adhesive dressing patch. During assembly, the nano-silver biological protein fiber cloth layer of the moisture absorption physiotherapy chip layer is attached to the protective film layer. The dressing patch can solve the problems that when an existing dressing patch is used for treating wounds which are large or deep in wound surface and long in healing period, the dressing patch is frequently replaced, and the wound healing promoting effect is not ideal.

Description

Technical Field

[0001] The invention relates to the technical field of medical dressings, and more particularly to a method for preparing a nano-silver medical wound self-adhesive dressing. Background Art

[0002] At present, there are many kinds of medical dressings on the market, for example: Patent CN2173600Y discloses a medical multi-layer wound patch, which includes a non-stick gauze layer, an adsorbent material layer, a protective film layer, a breathable tape layer, and inner and outer packaging, etc.; Patent CN201912320U discloses a new type of medical wound patch, which consists of an inner layer and two outer layers, the inner layer is a moisture-absorbing material anti-adhesive layer, and the two outer layers are non-woven tape layers and protective film layers. These medical dressings have the following disadvantages: First, they cannot be dissolved in the wound. If the anti-adhesion technology is not properly handled, they will adhere to the wound. Once adhered, it will cause secondary trauma to the wound; second, the processing technology is complicated and the product cost is too high.

[0003] In order to solve the above defects, patent CN209203745U discloses a quantum medical wound self-adhesive dressing, the structure of which is as follows Figure 1 As shown, it includes a tape layer, a hygroscopic therapy chip layer and a protective film layer. The hygroscopic therapy chip layer is provided with grooves to increase the absorption of wound exudate by the hygroscopic therapy chip layer, thereby providing a suitable microenvironment for wound healing. In addition, the patent uses alginate fiber as the raw material of the hygroscopic therapy chip, which has the advantages of safety, non-toxicity, high hygroscopicity, hemostasis, and gelation. However, when the medical self-adhesive wound dressing is used to treat wounds with larger or deeper wounds, due to the long wound healing cycle, the dressing still needs to be replaced frequently to ensure that the wound has a more suitable healing biological environment, which not only increases the workload of medical staff, but also is not conducive to the recovery of the patient's wound. Therefore, it is necessary to further improve the medical self-adhesive wound dressing so that it has a longer service life and a better effect of promoting wound healing. Summary of the invention

[0004] To this end, the technical problem to be solved by the present invention is to provide a method for preparing a nanosilver medical wound self-adhesive dressing patch to solve the problems of frequent replacement of the existing dressing patches and unsatisfactory wound healing effect when used to treat wounds with larger or deeper wounds and longer healing cycles.

[0005] In order to solve the above technical problems, the present invention provides the following technical solutions:

[0006] The preparation method of the above-mentioned nano silver medical wound self-adhesive dressing comprises the following steps:

[0007] Step (1), preparing bioprotein fiber cloth;

[0008] Step (2), soaking the bioprotein fiber cloth in the nanosilver solution and then drying it to obtain the nanosilver bioprotein fiber cloth;

[0009] Step (3), cutting the nano silver bioprotein fiber cloth and the water-absorbent fiber cloth into a composite roll to obtain a moisture-absorbent physiotherapy chip layer;

[0010] Step (4), assembling and packaging the hygroscopic therapy chip layer, the tape layer and the protective film layer to obtain the nano-silver medical wound self-adhesive dressing; during assembly, the nano-silver bio-protein fiber cloth layer of the hygroscopic therapy chip layer is bonded to the protective film layer.

[0011] In the experiment, it was found that if the biological protein fiber prepared by the present invention is soaked in a nano-silver solution and then mixed with the water-absorbing fiber used in the present invention, no matter how the mixing ratio of the two is adjusted, the obtained blended cloth is used as a moisture-absorbing physiotherapy chip layer, and the assembled dressing is used to treat wounds with a larger or deeper wound surface and a longer healing period. The moisture absorption effect on the wound exudate and the effect of promoting wound healing are not ideal, and if the replacement is not timely, the problem of wound adhesion is likely to occur. However, the double-layer structure obtained by composite rolling and cutting the nano-silver biological protein fiber cloth and the water-absorbing fiber cloth of the present invention is used as the moisture-absorbing physiotherapy chip layer, and the nano-silver biological protein fiber cloth layer of the moisture-absorbing physiotherapy chip layer is aligned with the wound during use, which not only shows a better moisture absorption effect, but also has a significantly better effect of promoting wound healing, and significantly extends the service life of the dressing without the problem of wound adhesion.

[0012] In the preparation method of the above-mentioned nano-silver medical wound self-adhesive dressing, in step (1), the preparation method of the bioprotein fiber cloth is:

[0013] Step (1-1), adding dried shrimp and / or crab shell as biological protein raw materials into alkaline solution, boiling and soaking, filtering after soaking to obtain a filtrate; adding hydrochloric acid solution to the filtrate and stirring thoroughly to obtain a mixed suspension;

[0014] Step (1-2), dehydrating and drying the solid obtained by centrifuging the mixed suspension to obtain the biological protein;

[0015] Step (1-3), dissolving the obtained biological protein in water to make silk, to obtain biological protein fiber;

[0016] Step (1-4), weaving the bioprotein fiber into a cloth to obtain a bioprotein fiber cloth.

[0017] The preparation method of the above-mentioned nano-silver medical wound self-adhesive dressing, in step (1-1), the biological protein raw material is a mixture of shrimp skin and crab shell, and the mass ratio of shrimp skin to crab shell is 1:2-3; the mass ratio of the biological protein raw material to the alkali solution is 1:8-10; the alkali solution is a sodium hydroxide solution with a mass concentration of 15wt%-20wt%; the immersion time is 2-5h; the concentration of the hydrochloric acid solution is 0.5-1.0mol / L, and the volume ratio of the filtrate to the hydrochloric acid solution is 5-8:1.

[0018] In the preparation method of the above-mentioned nano-silver medical wound self-adhesive dressing, in step (1-2), the drying temperature when drying the solid is 50-60° C. and the drying time is 5-8 hours.

[0019] In the preparation method of the above-mentioned nano-silver medical wound self-adhesive dressing, in step (1-3), the thickness of the biological protein fiber is 1.5D; in step (1-4), the density of the biological protein fiber cloth is controlled to be 60-80g / m 2 .

[0020] In the preparation method of the nanosilver medical wound self-adhesive dressing, in step (2), the concentration of the nanosilver solution is 50-100 mg / L, and the particle size of the nanosilver is 2-5 nm. Compared with nanosilver solutions of other particle sizes, the nanosilver solution of this particle size within the above concentration range can be evenly loaded onto the bioprotein fiber cloth when soaking the bioprotein fiber cloth, and has a promoting effect on the antibacterial effect of the bioprotein fiber cloth.

[0021] In the preparation method of the above-mentioned nano-silver medical wound self-adhesive dressing, in step (2), the soaking time is 2 to 5 hours; the drying temperature during drying is 50 to 60° C., and the drying time is 8 to 12 hours.

[0022] In the preparation method of the nano-silver medical wound self-adhesive dressing, the water-absorbent fiber cloth is artificial cotton cloth, bamboo fiber cloth or silk cloth.

[0023] In the preparation method of the nano-silver medical wound self-adhesive dressing, the thickness of the water-absorbent fiber cloth is 2.5-3.5 mm, and the thickness of the nano-silver bioprotein fiber cloth is 0.5-1.0 mm.

[0024] The preparation method of the above-mentioned nano-silver medical wound self-adhesive dressing patch, the preparation method of the tape layer is: use a medical nano-grade polyurethane PU film, nano-grade ice silk cloth, nano-grade silk cloth, nano-grade artificial cotton cloth or a medical nano-grade polyethylene film as a carrier, first use a hot embossing method to open an interlocking groove for laying a hygroscopic physiotherapy chip layer on the carrier, and then spray a polymer medical oil glue on the side of the carrier with the interlocking groove and dry it. The spraying thickness of the polymer medical oil glue is less than or equal to 0.1nm; the polymer medical oil glue used has unchanged viscosity in an environment of -40°C to 40°C; the protective film layer is a medical polyurethane film, a medical polyethylene film or a glassine silicon film.

[0025] The technical solution of the present invention achieves the following beneficial technical effects:

[0026] 1. The present invention uses a self-made high-protein fiber cloth and a highly absorbent fiber cloth to form a hygroscopic physiotherapy chip layer. Compared with the alginate fiber as the chip layer in the background technology CN209203745U, in addition to the advantages of safety, non-toxicity, hemostasis, and gelation of the alginate fiber chip, its hygroscopicity has been significantly improved. The hygroscopic physiotherapy chip layer of the present invention can absorb 30 times the weight of liquid equivalent to its own weight, and has an ideal absorption effect on wound exudate; and, compared with the alginate fiber chip layer, the hygroscopic physiotherapy chip layer of the present invention has a more prominent effect on promoting wound healing. When used to treat wounds with larger or deeper wounds, the replacement cycle of the dressing is significantly extended, and there will be no problem of wound adhesion.

[0027] 2. The method of the present invention is used to prepare bioprotein fiber cloth. Compared with the common bioprotein fiber cloth on the market, the bioprotein fiber cloth prepared by using shrimp skin and / or crab shell as the bioprotein raw material not only has a better healing effect and a longer service life for deeper and larger wounds, but also can effectively improve the scar formation problem of deeper and larger wounds. This may be related to the fact that shrimp skin and / or crab shell contain a large amount of chitosan. The bioprotein fiber prepared by the preparation method of the present invention may be mixed with chitosan, so that when the dressing is used, the wound heals faster under the joint action of chitosan, bioprotein and nanosilver. In addition, due to the presence of the absorbent fiber cloth layer, the exudate from the wound surface passes through the bioprotein fiber cloth layer and is stored in the absorbent fiber cloth layer, so that the wound can maintain a suitable humidity for a long time without adhesion to the dressing, thereby effectively extending the service life of the dressing. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] Figure 1 Schematic diagram of the structure of quantum nanosilver medical wound self-adhesive dressing in the background art.

[0029] The reference numerals in the figure are as follows: 10 - tape layer; 11 - carrier; 12 - polymer oil layer; 13 - fitting groove; 20 - chip layer; 21 - groove; 30 - protective film layer; 31 - first film layer; 32 - second film layer; 33 - tear line. DETAILED DESCRIPTION

[0030] The preparation method of the nano silver medical wound self-adhesive dressing comprises the following steps:

[0031] Step (1), preparing bioprotein fiber cloth; the preparation method of bioprotein fiber cloth is:

[0032] Step (1-1), adding shrimp skins and crab shells as biological protein raw materials into an alkali solution, boiling and soaking them, filtering after soaking to obtain a filtrate; adding a hydrochloric acid solution to the filtrate and fully stirring it to obtain a mixed suspension; in this embodiment, the biological protein raw material is a mixture of shrimp skins and crab shells, and the mass ratio of shrimp skins to crab shells is 1:3; the mass ratio of the biological protein raw material to the alkali solution is 1:8; the alkali solution is a sodium hydroxide solution with a mass concentration of 15wt%; the soaking time is 5h; the concentration of the hydrochloric acid solution is 1.0mol / L, and the volume ratio of the filtrate to the hydrochloric acid solution is 5:1.

[0033] Step (1-2), dehydrating and drying the solid obtained by centrifuging the mixed suspension to obtain biological protein; in this embodiment, the drying temperature when drying the solid is 60°C; and the drying time is 8 hours.

[0034] Step (1-3), dissolving the obtained biological protein in water to make silk, to obtain biological protein fiber. The thickness of the biological protein fiber prepared in this embodiment is 1.5D;

[0035] Step (1-4), weaving the bioprotein fiber into a cloth to obtain a bioprotein fiber cloth; the density of the bioprotein fiber cloth prepared in this embodiment is 80g / m 2 .

[0036] Step (2), soaking the bioprotein fiber cloth in the nanosilver solution and then drying it to obtain the nanosilver bioprotein fiber cloth; the concentration of the nanosilver solution used in this embodiment is 80 mg / L, and the particle size of the nanosilver is 2 to 5 nm; the soaking time is 5 h; the drying temperature during drying is 50° C., and the drying time is 12 h.

[0037] Step (3), composite rolling and cutting the nano-silver bio-protein fiber cloth and the water-absorbent fiber cloth to obtain a moisture-absorbing physiotherapy chip layer; in this embodiment, the water-absorbent fiber cloth is artificial cotton cloth; the thickness of the water-absorbent fiber cloth is 2.5 mm, and the thickness of the nano-silver bio-protein fiber cloth is 0.5 mm.

[0038] Step (4), assembling and packaging the hygroscopic therapy chip layer, the tape layer and the protective film layer to obtain the nano-silver medical wound self-adhesive dressing; the preparation method of the tape layer in this embodiment is: using nano-grade artificial cotton cloth as a carrier, firstly using a hot embossing method to open an interlocking groove for laying the hygroscopic therapy chip layer on the carrier, and then spraying a polymer medical oil glue on the side of the carrier with the interlocking groove and drying it, and the spraying thickness of the polymer medical oil glue is less than or equal to 0.1nm; the viscosity of the polymer medical oil glue used remains unchanged in an environment of -40℃ to 40℃; the protective film layer is a medical polyurethane film; during assembly, the nano-silver bioprotein fiber cloth layer of the hygroscopic therapy chip layer is bonded to the protective film layer.

[0039] The dressing patch of this embodiment was used in clinical trials. Compared with existing dressing patches, the wound healing speed was faster and there was no problem of adhesion to the wound. Compared with the dressing patch in the background technology, when it was used for larger or deeper wounds, the replacement cycle of the dressing patch was extended by 1.5 times, and the formation of scars on the wound surface could be effectively reduced.

[0040] Obviously, the above embodiments are merely examples for the purpose of clear explanation, and are not intended to limit the implementation methods. For those skilled in the art, other different forms of changes or modifications can be made based on the above description. It is not necessary and impossible to list all the implementation methods here. The obvious changes or modifications derived therefrom are still within the scope of protection of the claims of this patent application.

Claims

1. A method for preparing a nano-silver medical wound self-adhesive dressing, characterized in that: The steps include: Step (1), preparing bioprotein fiber cloth; Step (2), soaking the bioprotein fiber cloth in the nanosilver solution and then drying it to obtain the nanosilver bioprotein fiber cloth; Step (3), cutting the nano silver bioprotein fiber cloth and the water-absorbent fiber cloth into a composite roll to obtain a moisture-absorbent physiotherapy chip layer; Step (4), assembling and packaging the hygroscopic therapy chip layer, the tape layer and the protective film layer to obtain the nano-silver medical wound self-adhesive dressing; during assembly, the nano-silver bio-protein fiber cloth layer of the hygroscopic therapy chip layer is bonded to the protective film layer.

2. The method for preparing the nano silver medical wound self-adhesive dressing according to claim 1, characterized in that: In step (1), the preparation method of the bioprotein fiber cloth is: Step (1-1), adding dried shrimp and / or crab shell as biological protein raw materials into alkaline solution, boiling and soaking, filtering after soaking to obtain a filtrate; adding hydrochloric acid solution to the filtrate and stirring thoroughly to obtain a mixed suspension; Step (1-2), dehydrating and drying the solid obtained by centrifuging the mixed suspension to obtain the biological protein; Step (1-3), dissolving the obtained biological protein in water to make silk, to obtain biological protein fiber; Step (1-4), weaving the bioprotein fiber into a cloth to obtain a bioprotein fiber cloth.

3. The method for preparing the nano silver medical wound self-adhesive dressing according to claim 2, characterized in that: In step (1-1), the biological protein raw material is a mixture of shrimp skins and crab shells, and the mass ratio of the shrimp skins to the crab shells is 1:2-3; the mass ratio of the biological protein raw material to the alkali solution is 1:8-10; the alkali solution is a sodium hydroxide solution with a mass concentration of 15wt%-20wt%; the soaking time is 2-5h; the concentration of the hydrochloric acid solution is 0.5-1.0mol / L, and the volume ratio of the filtrate to the hydrochloric acid solution is 5-8:

1.

4. The method for preparing the nano silver medical wound self-adhesive dressing according to claim 2, characterized in that: In step (1-2), the drying temperature for drying the solid is 50 to 60° C. and the drying time is 5 to 8 hours.

5. The method for preparing the nano silver medical wound self-adhesive dressing according to claim 2, characterized in that: In step (1-3), the thickness of the bioprotein fiber is 1.5D; in step (1-4), the density of the bioprotein fiber cloth is controlled to be 60-80g / m 2 .

6. The method for preparing the nano silver medical wound self-adhesive dressing according to claim 1, characterized in that: In step (2), the concentration of the nanosilver solution is 50-100 mg / L, and the particle size of the nanosilver is 2-5 nm.

7. The method for preparing the nano-silver medical wound self-adhesive dressing according to claim 4, characterized in that: In step (2), the soaking time is 2 to 5 hours; the drying temperature during drying is 50 to 60° C., and the drying time is 8 to 12 hours.

8. The method for preparing the nano-silver medical wound self-adhesive dressing according to any one of claims 1 to 7, characterized in that: The water-absorbent fiber cloth is artificial cotton cloth, bamboo fiber cloth or silk cloth.

9. The method for preparing the nano silver medical wound self-adhesive dressing according to claim 8, characterized in that: The thickness of the water-absorbent fiber cloth is 2.5-3.5 mm, and the thickness of the nano-silver bioprotein fiber cloth is 0.5-1.0 mm.

10. The method for preparing the nano-silver medical wound self-adhesive dressing according to claim 9, characterized in that: The preparation method of the tape layer is as follows: using a medical nano-grade polyurethane PU film, nano-grade ice silk cloth, nano-grade silk cloth, nano-grade artificial cotton cloth or a medical nano-grade polyethylene film as a carrier, firstly using a hot embossing method to open an interlocking groove for laying a hygroscopic physiotherapy chip layer on the carrier, and then spraying a polymer medical oil glue on one side of the carrier with the interlocking groove and then drying it, wherein the spraying thickness of the polymer medical oil glue is less than or equal to 0.1nm; the viscosity of the polymer medical oil glue used remains unchanged in an environment of -40°C to 40°C; the protective film layer is a medical polyurethane film, a medical polyethylene film or a glassine silicon film.

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