Double-balloon fixable animal perfusion device

Abstract

The invention discloses a double-balloon fixable animal perfusion device. The device comprises a supporting tube; the isolation plug is placed in the supporting pipe; the end cover is detachably arranged at one end of the supporting pipe, and one end of the end cover is in contact with one end of the isolation plug; the puncture needle penetrates through the supporting tube, the isolation plug and the end cover; the double-balloon assembly comprises a deformable first fixing balloon and a deformable second fixing balloon, one end of the first fixing balloon is connected to the outer wall of the supporting tube in a sealed mode, and a first connecting part is connected between the first fixing balloon and the second fixing balloon; the double-balloon assembly further comprises a supporting cover, a second connecting part is connected between the supporting cover and the second fixing balloon, and a first inlet pipe is connected to the supporting cover. According to the invention, different use requirements can be conveniently met.

Description

Technical Field

[0001] The invention relates to the technical field of animal testing equipment, in particular to a double-balloon fixed animal perfusion device. Background Art

[0002] In animal perfusion tests, the existing perfusion devices are not convenient for properly fixing the part to be perfused, which can easily cause the perfusion device to move, thereby affecting the accuracy and stability of the perfusion; in addition, the existing perfusion devices have poor flexibility in use. Summary of the invention

[0003] The purpose of the present invention is to provide a double-balloon fixed animal perfusion device, which improves the flexibility of use and facilitates meeting different use requirements.

[0004] In order to solve the above technical problems, the present invention provides the following technical solutions: a double-balloon fixed animal perfusion device, comprising: a support tube; an isolation plug, the isolation plug is placed inside the support tube; an end cap, the end cap is detachably arranged at one end of the support tube, and one end of the end cap is in contact with one end of the isolation plug; a puncture needle, the puncture needle passes through the support tube, the isolation plug and the end cap; a double-balloon assembly, the double-balloon assembly comprises a deformable first fixed balloon and a second fixed balloon, one end of the first fixed balloon is sealed and connected to the outer wall of the support tube, and a first connecting portion is connected between the first fixed balloon and the second fixed balloon; the double-balloon assembly also includes a support cover, a second connecting portion is connected between the support cover and the second fixed balloon, and a first inlet pipe is connected to the support cover, and the first inlet pipe is used to connect an external gas injection or liquid injection device; a first extrusion assembly, the first extrusion assembly is used to extrude one end of the second fixed balloon adjacent to the first connecting portion; a second extrusion assembly, the second extrusion assembly is used to extrude one end of the second fixed balloon adjacent to the second connecting portion; wherein the support cover is sealed and connected to the second extrusion assembly.

[0005] Furthermore, the support tube includes: a straight line segment 1, which is arranged outside the puncture needle and is compatible with the puncture needle; a straight line segment 2, which is coaxial with the straight line segment 1; and a conical segment, which is arranged between the straight line segment 1 and the straight line segment 2; wherein the isolation plug is placed inside the straight line segment 2, and one end of the isolation plug contacts the inner wall of the conical segment.

[0006] Furthermore, the first extrusion assembly includes: a first sleeve, which is coaxially arranged outside the support tube, and one end of the first sleeve is fixedly arranged on the conical segment; a first extrusion balloon, which is arranged at the other end of the first sleeve, and the first extrusion balloon is sealed and connected to the straight segment; wherein a second inlet pipe is connected to the first sleeve, and the second inlet pipe is used to connect to an external gas injection or liquid injection device.

[0007] Furthermore, the second extrusion assembly includes: a second sleeve, which is coaxially arranged outside the first sleeve, and one end of the second sleeve is fixedly arranged on the conical section; a second extrusion balloon, which is arranged at the other end of the second sleeve, and the second extrusion balloon is sealed and connected to the first sleeve; wherein the support cover is fixedly arranged on the second sleeve, and the second sleeve is connected to a third inlet pipe, and the third inlet pipe is used to connect to an external gas injection or liquid injection device.

[0008] Furthermore, the isolation plug is made of rubber or silicone.

[0009] Furthermore, a limiting hole is provided through the end cover, one end of the puncture needle is fixedly sleeved with a sleeve seat, and one end of the sleeve seat is fitted in the limiting hole.

[0010] Furthermore, two fixing rings are arranged on the outer wall of the second straight line segment.

[0011] Compared with the prior art, the beneficial effects achieved by the present invention are: the inflated first fixing balloon and the second fixing balloon respectively contact the inner and outer walls of the animal's ventricle, thereby achieving a fixed perfusion device; at the same time, by providing the first squeezing balloon and the second squeezing balloon, it is easy to meet different usage requirements, thereby facilitating adaptation to animals of different sizes and types and improving flexibility of use. BRIEF DESCRIPTION OF THE DRAWINGS

[0012] The accompanying drawings are used to provide further understanding of the present invention and constitute a part of the specification. They are used to explain the present invention together with the embodiments of the present invention and do not constitute a limitation of the present invention.

[0013] Figure 1 It is an overall schematic diagram of the first embodiment of the present invention.

[0014] Figure 2 It is an overall cross-sectional schematic diagram of the first embodiment of the present invention.

[0015] Figure 3 It is a schematic diagram of the positions of the first sleeve, the first squeezing balloon, the second sleeve, and the second squeezing balloon in the first embodiment of the present invention.

[0016] Figure 4It is a schematic diagram of the installation of the first extrusion assembly and the second extrusion assembly in the first embodiment of the present invention.

[0017] Figure 5 It is a schematic diagram of the cooperation between the end cover and the sleeve seat of the first embodiment of the present invention.

[0018] Figure 6 It is a schematic diagram of the expansion state of the first fixed balloon and the second fixed balloon in the first embodiment of the present invention.

[0019] Figure 7 It is a schematic diagram of the state in which the first squeezing balloon squeezes the second fixing balloon in embodiment 1 of the present invention.

[0020] Figure 8 It is a schematic diagram of the state in which the second squeezing balloon squeezes the second fixing balloon in embodiment 1 of the present invention.

[0021] Fig. 9 It is a schematic diagram of the installation of the fixing ring of the third embodiment of the present invention.

[0022] In the figure: 1. support tube; 11. straight line segment 1; 12. conical segment; 13. straight line segment 2; 131. fixing ring; 2. puncture needle; 3. double balloon assembly; 31. first fixed balloon; 32. first connecting part; 33. second fixed balloon; 34. second connecting part; 35. support cover; 36. first inlet pipe; 4. first extrusion assembly; 41. first extrusion balloon; 42. first sleeve; 43. second inlet pipe; 5. second extrusion assembly; 51. second extrusion balloon; 52. second sleeve; 53. third inlet pipe; 6. end cover; 61. limiting hole; 7. sleeve seat; 8. isolation plug. DETAILED DESCRIPTION

[0023] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0024] Embodiment 1

[0025] See also Figure 1-Figure 8The present invention provides a technical solution: a double-balloon fixed animal perfusion device, comprising a support tube 1 and a puncture needle 2, wherein the support tube 1 is composed of a straight segment 11, a conical segment 12 and a straight segment 2 13 in sequence, wherein the straight segment 11, the conical segment 12 and the straight segment 2 13 are coaxial; an end of the straight segment 2 13 away from the conical segment 12 is detachably provided with an end cap 6, the end cap 6 is a cylindrical structure as a whole, and a limiting hole 61 is provided at the center of the end cap 6, and the limiting hole 61 is coaxial with the end cap 6; the puncture needle 2 passes through the straight segment 11, the conical segment 12 and the straight segment 2 13, and the puncture needle 2 penetrates the limiting hole 61 on the end cap 6; an isolation plug 8 is placed in the support tube 1, and the puncture The needle 2 passes through the isolation plug 8, which is made of rubber or silicone and other materials. The puncture needle 2 passes through the isolation plug 8, which has a clamping effect on the puncture needle 2, thereby achieving a fixing effect on the puncture needle 2; specifically, the isolation plug 8 is placed in the straight line segment 13, and a part of the isolation plug 8 abuts against the inner wall of the conical segment 12, and one end of the end cover 6 abuts against the isolation plug 8; at the same time, the puncture needle 2 is adapted to the straight line segment 11, one end of the puncture needle 2 is set as a pointed tip, and this end of the puncture needle 2 slightly extends out of the straight line segment 11, and the other end of the puncture needle 2 is fixedly sleeved with a sleeve seat 7, a part of the sleeve seat 7 abuts against the end surface of the end cover 6, and one end of the sleeve seat 7 fits in the limiting hole 61.

[0026] The perfusion device also includes a double balloon assembly 3, a first extrusion assembly 4 and a second extrusion assembly 5. The double balloon assembly 3 includes a first fixed balloon 31 and a second fixed balloon 33. The first fixed balloon 31 is adjacent to the end of the straight line segment 11 away from the conical segment 12. A first connecting portion 32 is provided between the first fixed balloon 31 and the second fixed balloon 33. The double balloon assembly 3 also includes a support cover 35, which is sealed and connected to the second extrusion assembly 5. A second connecting portion 34 is provided between the support cover 35 and the second fixed balloon 33. The first fixed balloon 31, the second fixed balloon 33, the first connecting portion 32 and the second connecting portion 34 are all sleeved outside the straight line segment 11. The first fixed balloon 31 and the second fixed balloon 33 are deformable, while the first connecting part 32, the second connecting part 34 and the support cover 35 are not deformable; a first inlet pipe 36 is connected to the support cover 35, and the first inlet pipe 36 is used to connect to an external gas injection or liquid injection device, so as to introduce gas or liquid into the double balloon assembly 3, so as to achieve the expansion of the first fixed balloon 31 and the second fixed balloon 33; at the same time, the external gas injection device draws out the gas in the double balloon assembly 3 (the external liquid injection device can draw out the liquid in the gas in the double balloon assembly 3), and when the gas or liquid in the double balloon assembly 3 is drawn out again, the first fixed balloon 31 and the second fixed balloon 33 can become deflated again.

[0027] The first extrusion assembly 4 includes a first sleeve 42 coaxially arranged outside the support tube 1, one end of the first sleeve 42 is fixedly arranged on the outer wall of the conical section 12; the first sleeve 42 is composed of a straight tube part and a conical tube part, the conical tube part is fixedly arranged on the outer wall of the conical section 12, and the straight tube part is sleeved on the outside of the straight section 11; the first sleeve 42 is provided with a first extrusion balloon 41 at one end away from the conical section 12, and the first extrusion balloon 41 is sealed and connected to the outer wall of the straight section 11; the first extrusion balloon 41 is located at the first The second extrusion balloon 51 is located inside the second fixed balloon 33 and adjacent to one end of the second fixed balloon 33 connected to the first connecting portion 32; a second inlet tube 43 is connected to the first sleeve 42, the second inlet tube 43 penetrates the support tube 1, and the second inlet tube 43 is sealed and connected to the support tube 1; the second inlet tube 43 is used to be connected to an external gas injection or liquid injection device, so as to expand the first extrusion balloon 41; at the same time, the external gas injection device draws away the gas or the liquid injection device draws away the liquid, so that the first extrusion balloon 41 becomes deflated again.

[0028] The second extrusion assembly 5 includes a second sleeve 52 coaxially arranged outside the first sleeve 42, one end of the second sleeve 52 is fixedly arranged on the conical section 12, the second inlet pipe 43 penetrates the second sleeve 52, and the second inlet pipe 43 is sealed and connected to the second sleeve 52; the second sleeve 52 is also composed of a straight tube part and a conical tube part, and the support cover 35 is fixedly arranged on the conical tube part of the second sleeve 52; a second extrusion balloon 51 is arranged at one end of the second sleeve 52 away from the conical section 12, and the second extrusion balloon 51 is sealed and connected to the outer wall of the first sleeve 42; the second extrusion balloon 51 is located inside the second fixed balloon 33, and the second extrusion balloon 51 is adjacent to the end of the second fixed balloon 33 connected to the second connecting portion 34; a third inlet pipe 53 is connected to the second sleeve 52; the third inlet pipe 53 is also used to connect with an external gas injection or liquid injection device, so as to realize the expansion of the second extrusion balloon 51; at the same time, the external gas injection device draws away the gas or the liquid injection device draws away the liquid, so that the second extrusion balloon 51 becomes deflated again.

[0029] The external gas injection or liquid injection devices connected to the first inlet pipe 36, the second inlet pipe 43 and the third inlet pipe 53 all adopt existing technologies, and can realize functions such as gas supply and extraction or liquid injection and extraction, and also have the function of controlling flow, which can be specifically realized by using pumps, control valves, sensors, etc. This is existing and will not be repeated here.

[0030] When the perfusion device is used, the animal's chest cavity is first opened to locate the ventricle, and the puncture needle 2 together with the support tube 1, the first fixing balloon 31 and the first connecting portion 32 are inserted from the left ventricle; so that the first fixing balloon 31 and the second fixing balloon 33 are respectively located inside and outside the ventricle, and at this time, gas or liquid is introduced into the double balloon assembly 3 through an external gas injection or liquid injection device to expand the first fixing balloon 31 and the second fixing balloon 33, so that the first fixing balloon 31 and the second fixing balloon 33 are respectively against the inner and outer walls of the animal's left ventricle, thereby fixing the entire perfusion device; The length of the first connecting portion 32 can be set to 0.1-10 mm, and can be set to a suitable range according to the actual use object; at the same time, since the first squeezing balloon 41 and the second squeezing balloon 51 are also provided, the first squeezing balloon 41 and the second squeezing balloon 51 are respectively used to squeeze the two ends of the second fixed balloon 33; when the second fixed balloon 33 is expanded, the first squeezing balloon 41 is expanded, and the second squeezing balloon 51 is not expanded, the first squeezing balloon 41 squeezes the end of the second fixed balloon 33 adjacent to the first connecting portion 32 to deform toward the first fixed balloon 31, such as Figure 7 In the state shown, the distance between the first fixing balloon 31 and the second fixing balloon 33 is reduced, so that the entire perfusion device is fixed on the ventricle with a smaller wall thickness; when the second fixing balloon 33 is expanded, the second squeezing balloon 51 is expanded, and the first squeezing balloon 41 is not expanded, the second squeezing balloon 51 squeezes the end of the second fixing balloon 33 adjacent to the second connecting portion 34 to deform, that is, Figure 8 In the state shown, the second fixing balloon 33 is pulled, and the end of the second fixing balloon 33 adjacent to the first connecting portion 32 can reduce the squeezing effect on the animal's ventricle, thereby facilitating adaptation to the ventricle with thicker wall thickness and avoiding excessive pressure on the animal's ventricle.

[0031] When the first fixing balloon 31 and the second fixing balloon 33 respectively contact the inner and outer walls of the animal's left ventricle, the puncture needle 2 is pulled out through the cannula seat, and the support tube 1, the first fixing balloon 31, etc. remain in the animal's ventricle; and when the puncture needle 2 is separated from the isolation plug 8, the isolation plug 8 is automatically closed (the isolation plug 8 is made of rubber or silicone); thereafter, physiological saline can be injected into the support tube 1 through the needle of the injector through the end cover 6 and the isolation plug 8, so as to carry out subsequent perfusion work.

[0032] The perfusion device causes the first fixed balloon 31 and the second fixed balloon 33 to expand, and the first fixed balloon 31 and the second fixed balloon 33 respectively contact the inner and outer walls of the animal's ventricle, thereby realizing a fixed perfusion device; in addition, by providing the first extrusion balloon 41 and the second extrusion balloon 51, compared with the traditional double-balloon perfusion device, it is easier to meet different usage requirements, thereby facilitating adaptation to animals of different sizes and types and improving flexibility of use.

[0033] Embodiment 2

[0034] See also Figure 1-Figure 8 This embodiment is based on the first embodiment. Specifically, the end cover 6 is connected and fixed to the second straight line segment 13 by means of screws or buckles, so as to facilitate the disassembly of the end cover 6. After the end cover 6 is disassembled, it is convenient to remove and replace the isolation plug 8, thereby avoiding the puncture needle 2 from penetrating the isolation plug 8 multiple times and the isolation plug 8 failing to automatically close and seal when the puncture needle 2 is pulled out, that is, ensuring that the isolation plug 8 can automatically close and seal when the puncture needle 2 is pulled out.

[0035] Embodiment 3

[0036] See also Figure 1-Figure 9 This embodiment is based on the second embodiment, and two fixing rings 131 are fixedly provided on the outer wall of the second straight line segment 13; the two fixing rings 131 are provided, and the whole perfusion device can be stably held by passing fingers through the fixing rings 131, so that it is convenient to use.

[0037] Finally, it should be noted that the above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art can still modify the technical solutions described in the aforementioned embodiments or replace some of the technical features therein by equivalents. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A double-balloon fixed animal perfusion device, characterized in that: include: Support tube (1); An isolation plug (8), the isolation plug (8) being placed inside the support tube (1); an end cover (6), the end cover (6) being detachably arranged at one end of the support tube (1), and one end of the end cover (6) being in contact with one end of the isolation plug (8); A puncture needle (2), wherein the puncture needle (2) passes through the support tube (1), the isolation plug (8) and the end cover (6); A double-balloon assembly (3), the double-balloon assembly (3) comprising a deformable first fixed balloon (31) and a second fixed balloon (33), one end of the first fixed balloon (31) being sealed and connected to the outer wall of the support tube (1), a first connecting portion (32) being connected between the first fixed balloon (31) and the second fixed balloon (33); the double-balloon assembly (3) further comprising a support cover (35), a second connecting portion (34) being connected between the support cover (35) and the second fixed balloon (33), a first inlet pipe (36) being connected to the support cover (35), the first inlet pipe (36) being used to connect to an external gas injection or liquid injection device; A first extrusion assembly (4), the first extrusion assembly (4) being used to extrude an end of the second fixing balloon (33) adjacent to the first connecting portion (32); A second extrusion assembly (5), the second extrusion assembly (5) being used to extrude an end of the second fixing balloon (33) adjacent to the second connecting portion (34); Wherein, the support cover (35) is sealedly connected to the second extrusion assembly (5).

2. A double-balloon fixable animal perfusion device according to claim 1, characterized in that: The support tube (1) comprises: A straight line segment 1 (11), wherein the straight line segment 1 (11) is sleeved outside the puncture needle (2), and the straight line segment 1 (11) is adapted to the puncture needle (2); A second straight line segment (13), wherein the second straight line segment (13) is coaxial with the first straight line segment (11); A conical segment (12), wherein the conical segment (12) is arranged between the straight line segment 1 (11) and the straight line segment 2 (13); The isolation plug (8) is placed inside the second straight line segment (13), and one end of the isolation plug (8) contacts the inner wall of the conical segment (12).

3. A double-balloon fixable animal perfusion device according to claim 2, characterized in that: The first extrusion assembly (4) comprises: A first sleeve (42), the first sleeve (42) being coaxially arranged outside the support tube (1), and one end of the first sleeve (42) being fixedly arranged on the conical section (12); A first squeezing balloon (41), wherein the first squeezing balloon (41) is arranged at the other end of the first sleeve (42), and the first squeezing balloon (41) is sealedly connected to the straight line segment 1 (11); Wherein, the first sleeve (42) is connected to a second inlet pipe (43), and the second inlet pipe (43) is used to connect to an external gas injection or liquid injection device.

4. A double-balloon fixable animal perfusion device according to claim 3, characterized in that: The second extrusion assembly (5) comprises: a second sleeve (52), the second sleeve (52) being coaxially arranged outside the first sleeve (42), and one end of the second sleeve (52) being fixedly arranged on the conical section (12); A second squeezing balloon (51), wherein the second squeezing balloon (51) is arranged at the other end of the second sleeve (52), and the second squeezing balloon (51) is sealedly connected to the first sleeve (42); The support cover (35) is fixedly arranged on the second sleeve (52), the second sleeve (52) is connected with a third inlet pipe (53), and the third inlet pipe (53) is used to connect to an external gas injection or liquid injection device.

5. A double-balloon fixable animal perfusion device according to claim 1, characterized in that: The isolation plug (8) is made of rubber or silicone.

6. A double-balloon fixable animal perfusion device according to claim 1, characterized in that: The end cover (6) is provided with a limiting hole (61) extending therethrough, one end of the puncture needle (2) is fixedly sleeved with a sleeve seat (7), and one end of the sleeve seat (7) is fitted in the limiting hole (61).

7. A double-balloon fixable animal perfusion device according to claim 2, characterized in that: Two fixing rings (131) are arranged on the outer wall of the second straight line segment (13).

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