Traditional Chinese medicine composition for removing acnes, preparation method of traditional Chinese medicine composition and traditional Chinese medicine mask cream

Abstract

The invention relates to the field of acne-removing products, aims to solve the problem that the acne-removing products are difficult to be suitable for acne types caused by different factors, and provides a traditional Chinese medicine composition for removing acnes, which is prepared from the following components in parts by weight: 80 to 170 parts of bletilla striata, 105 to 210 parts of radix paeoniae rubra, 120 to 265 parts of herba portulacae, 110 to 230 parts of dandelion, 90 to 210 parts of herba violae and 115 to 310 parts of fructus forsythiae. The traditional Chinese medicine composition for removing acnes, provided by the invention, has the effects of clearing away heat and toxic materials, diminishing swelling and removing stasis, resisting bacteria, resisting inflammation and whitening after the six traditional Chinese medicines are combined. Wherein fructus forsythiae is used as a main drug and has the effect of killing propionibacterium acnes, dandelion and herba violae are used as ministerial drugs and have the effects of resisting inflammation and oxidation, purslane is used as an adjuvant drug and has the effects of resisting bacteria, diminishing inflammation, removing cutin and repairing cuticles, and rhizoma bletillae and radix paeoniae rubra are used as conductant drugs and have the effects of resisting oxidative stress and improving blood circulation; the traditional Chinese medicine mask cream provided by the invention can promote the absorption of traditional Chinese medicine components, and also has good moisture retention, film-forming property, aging resistance and the like.

Description

Technical Field

[0001] The invention relates to the field of acne-removing products, and in particular to a Chinese medicine composition for acne-removing and a preparation method thereof, and a Chinese medicine facial mask cream. Background Art

[0002] Acne or pimples mostly occur in teenagers and are related to a variety of factors, including excessive sebum secretion, abnormal keratinization of hair follicles, bacterial infection, inflammatory response, and changes in hormone levels. Currently, acne-removing products are relatively simple in terms of efficacy, such as cleaning, anti-inflammatory and antibacterial, and inhibiting sebum secretion. They may have a better effect on acne caused by certain factors or types of factors, but are difficult to apply to most types of acne. Summary of the invention

[0003] The purpose of the present invention is to provide a Chinese medicine composition for acne removal and a preparation method thereof, and a Chinese medicine facial mask cream, so as to solve the problem that acne removal products are difficult to be applied to acne types caused by different factors.

[0004] The embodiments of the present invention are implemented by the following technical solutions:

[0005] A Chinese medicine composition for removing acne comprises the following components in parts by weight: 80-170 parts of bletilla striata, 105-210 parts of red peony root, 120-265 parts of purslane, 110-230 parts of dandelion, 90-210 parts of Viola yedoensis and 115-310 parts of forsythia.

[0006] Acne is a chronic inflammatory skin disease caused by abnormal secretion and metabolism of skin oil. It often appears in areas with strong sebum secretion such as the face, chest and back. Acne, papules, nodules, cysts, pustules, scars, etc. are common symptoms. Hormone imbalance, excessive sebum secretion, excessive keratinization of the sebaceous gland ducts of the hair follicles, excessive proliferation of Propionibacterium acnes, inflammatory immune response, etc. are the main causes of acne. The imbalance of human hormone levels can lead to the rapid development of sebaceous glands and abnormal sebum secretion, thus causing acne symptoms; excessive keratinization of the sebaceous gland ducts of the hair follicles causes sebum and epithelial cells to accumulate at the opening of the hair follicles, inducing the formation of acne; the large-scale reproduction of Propionibacterium acnes in the hair follicles prompts sebum to produce free fatty acids, which ultimately induces an inflammatory response.

[0007] In view of the above-mentioned mechanism of acne occurrence, the effect of oil control and acne removal can be achieved by inhibiting sebum secretion, exfoliating, inhibiting the growth and reproduction of Propionibacterium acnes, and alleviating inflammation.

[0008] Bletilla striata polysaccharide is the main active ingredient of the traditional Chinese medicine Bletillastriata (Thunb. ex Murray) Rchb.F., with a content of up to (43.95±0.26)% in Bletilla striata. It has strong hygroscopic and moisturizing properties. Bletilla striata polysaccharide has antioxidant and anti-inflammatory effects, and can inhibit AngⅡ-induced ROS production and the activation of proinflammatory cytokines.

[0009] Red peony root is a traditional Chinese medicine that has the effects of clearing away heat and detoxifying, promoting blood circulation and removing blood stasis. It has a certain auxiliary effect on acne removal. According to the theory of traditional Chinese medicine, red peony root can improve blood circulation, reduce skin inflammation, and help acne heal. It inhibits skin inflammatory reactions, promotes skin tissue repair, and reduces the redness and swelling of acne.

[0010] Purslane is rich in various nutrients and bioactive substances, and is widely used in medicine and health care. There are many important metabolites in Purslane, which contain a variety of chemical components, such as flavonoids, alkaloids, terpenes, organic acids and polysaccharides. Its active ingredients have good effects in anti-inflammatory, antibacterial, anti-allergic, anti-oxidant, exfoliating, repairing keratin, promoting skin healing, inhibiting sebum secretion, etc., and have great potential in the treatment of acne. At the same time, Purslane extract has a variety of functions in cosmetics, such as antibacterial, anti-inflammatory, exfoliating, repairing stratum corneum, etc. At the same time, Purslane extract has a role in repairing damage and protecting the skin, including promoting wound healing, preventing photoaging, anti-aging, anti-oxidation, anti-allergy and other effects.

[0011] Dandelion is a common medicinal and edible plant that contains flavonoids, polysaccharides, phenolic acids and other substances. It has antibacterial and anti-inflammatory, whitening and antioxidant effects.

[0012] Viola yedoensis contains more than 10 active ingredients, including flavonoids and their glycosides, organic acids, and coumarin components. Flavonoids and their glycosides are the main components. Flavonoid compounds include apigenin and its glycosides, luteolin and its glycosides, etc. Apigenin and its glycosides have many beneficial effects on the skin, such as anti-irritation, anti-inflammatory, anti-allergic, and anti-aging; luteolin and its glycosides can inhibit the growth of Staphylococcus and Bacillus subtilis; have anti-inflammatory effects, and can be used with phospholipids to treat dermatitis; inhibit hyaluronidase activity, and use with hyaluronic acid can prolong the physiological activity of the substance; have a strong ability to capture oxygen-containing free radicals. In summary, Viola yedoensis extract has antibacterial, anti-inflammatory, and antioxidant effects, and contains a variety of flavonoid compounds that are beneficial to the skin.

[0013] The forsythia glycosides in Forsythia suspensa have a strong inhibitory effect on a variety of pathogenic bacteria and endotoxins.

[0014] In summary, the external use of these six Chinese herbal extracts can play the role of clearing away heat and detoxification, reducing swelling and dispersing knots, antibacterial, anti-inflammatory and whitening. Among them, Forsythia suspensa is the main drug, which plays a role in killing Propionibacterium acnes, Taraxacum officinale and Viola yedoensis are the assistant drugs, which play an anti-inflammatory and antioxidant role, Portulaca oleracea is the adjuvant drug, which plays an antibacterial, anti-inflammatory, exfoliating and repairing stratum corneum role, Bletilla striata and Paeonia lactiflora are the guiding drugs, which play an anti-oxidative stress and improve blood circulation.

[0015] Preferably, the components are as follows, in parts by weight: 160 parts of Bletilla striata, 160 parts of Red Peony Root, 200 parts of Portulaca Oleracea, 180 parts of Taraxacum Officinale, 185 parts of Viola Yedoensis, and 200 parts of Forsythia suspensa.

[0016] A method for preparing the acne-removing Chinese medicine composition comprises:

[0017] S100, dissolving and extracting all medicinal materials once to obtain a dissolution solution and a dissolved material; the material-liquid ratio of medicinal materials to solvent is 1:18-1:10;

[0018] S200, performing secondary dissolution extraction on the material after the primary dissolution to obtain a secondary dissolution liquid; the material-liquid ratio of the medicinal material to the solvent is 1:9-1:7; combining the primary dissolution liquid and the secondary dissolution liquid to obtain a mixed solution;

[0019] S300, filtering, centrifuging and concentrating the mixed solution to obtain a Chinese medicine composition for acne removal.

[0020] Preferably, the S100 includes:

[0021] Adding Bletilla striata and Paeonia lactiflora to water and decocting once to obtain a first decoction liquid and a first decoction material; the decoction temperature is 75-85° C., the material-liquid ratio is 1:12-1:10, and the decoction time is 100-140 minutes;

[0022] Add purslane, dandelion, Viola yedoensis and Forsythia suspensa to ethanol, evaporate the ethanol after heating in a water bath to obtain a first extract and a post-extract material, the water bath temperature is 80-100°C, the material-liquid ratio is 1:18-1:15, the water bath time is 1.5-2.5h, and the ethanol concentration is 70%-85%.

[0023] Bletilla striata is rich in a large amount of adhesive substances, the main component of which is glucomannan, which is soluble in water to form a relatively viscous hydrophilic glue. Red peony root contains more active substances, such as monoterpene glycosides, triterpene glycosides and other glycoside compounds, and also contains polyphenols, flavonoids, aromatic acids and other ester compounds. Glycoside compounds are the main active substances in red peony root, which are water-soluble components. After considering the dissolution characteristics and stability of the effective ingredients of the two medicinal materials, the present invention extracts Bletilla striata and red peony root together in a specific extraction method.

[0024] Purslane contains many active substances such as flavonoids, polysaccharides, polyphenols, etc., which have various functions such as analgesia, anti-inflammatory, antibacterial and antioxidant. There are many methods for extracting flavonoids from purslane, and the most common ones are solvent extraction, ultrasonic-assisted extraction, microwave-assisted extraction and enzymatic hydrolysis. Among them, the heating reflux water extraction method has a high extraction rate and is green and environmentally friendly. Based on the certain solubility of flavonoids in water, the total flavonoids in purslane can be extracted by heating reflux method. The main active substance of dandelion is flavonoids; Viola yedoensis has antibacterial, anti-inflammatory, antiviral, antioxidant, anticancer, immunomodulatory and other effects, and the main active substance is flavonoids; Forsythia suspensa is rich in flavonoids, alkaloids, volatile oils and other substances, among which flavonoids are important substances with unique biological activity of Forsythia suspensa. Since the main active substances of the above four medicinal materials are mainly flavonoids, the present invention combines these four medicinal materials in a specific extraction method for extraction.

[0025] Preferably, before the first decoction, the Bletilla striata and the Red Peony Root are dried and crushed to form drug particles, the drying temperature is 50-60° C., the particle size of the drug particles is ≤20 mesh, and the water content of the drug particles is 10%-12%.

[0026] Preferably, before adding ethanol, purslane, dandelion, Viola yedoensis and forsythia are dried and crushed to form drug particles, the drying temperature is 65-70° C., the particle size of the drug particles is 50-60 mesh, and the water content of the drug particles is 10%-12%.

[0027] Preferably, the step S200 comprises: adding water to the first decoction material and decocting it twice to obtain a second decoction liquid, wherein the decoction temperature is 75-85° C. and the decoction time is 50-70 min, and the first decoction liquid and the second decoction liquid are combined to obtain a first medicinal liquid;

[0028] The extracted material is added to ethanol, and the ethanol is evaporated after heating in a water bath to obtain a second extract, the water bath temperature is 80-100°C, the water bath time is 0.8-1.2h, the ethanol concentration is 70%-85%, and the first extract and the second extract are combined to obtain a second drug solution;

[0029] The first liquid medicine and the second liquid medicine are combined to obtain the mixed solution.

[0030] Preferably, the centrifugal speed in S300 is 250-350 r / min, and the centrifugal time is 8-12 min.

[0031] Preferably, the relative density of the acne-removing traditional Chinese medicine composition is 1.05-1.25 g / ml.

[0032] A Chinese medicine facial mask cream comprises, by weight: 500-550 parts of a Chinese medicine composition for removing acne, 0.06-0.08 parts of sodium hyaluronate, 30-40 parts of honey, 33-38 parts of propylene glycol, 33-38 parts of glycerol, 15-20 parts of cyclopentasiloxane, 8-12 parts of squalane, 6-8 parts of cetearyl alcohol, 6-8 parts of elaeis guineensis kernel oil, 4-6 parts of polydimethylsiloxane, 4-6 parts of caprylic / capric triglyceride, 3-5 parts of cetearyl alcohol, 0.6-0.8 parts of fucose and 150-180 parts of water.

[0033] Hyaluronic acid has a powerful effect of moisturizing and repairing the skin barrier. In addition, when Viola yedoensis is used together with hyaluronic acid, it can also inhibit the activity of hyaluronidase. When used together with hyaluronic acid, it can prolong the physiological activity of the substance.

[0034] Honey is a natural moisturizer. The moisturizing factors in honey can help the stratum corneum cells absorb water and swell. Honey is rich in hydrogen peroxide, phenolic compounds and other substances with antibacterial effects, which can inhibit the growth and reproduction of many kinds of bacteria. Honey also has antioxidant repair, gentle cleansing and soothing functions.

[0035] When propylene glycol works synergistically with other moisturizing ingredients such as hyaluronic acid and glycerin, it can further enhance the overall moisturizing effect. Propylene glycol can help other active ingredients penetrate the stratum corneum faster and reach the bottom layer of the skin to work, thereby increasing the utilization rate of various active ingredients in the mask. Propylene glycol can be used as a solvent to dissolve certain oily ingredients that are not easily soluble in water.

[0036] Cyclopentasiloxane and polydimethicone allow facial masks to dry quickly and form a film. The protective film they form can effectively resist the intrusion of external moisture and keep the skin dry, which is especially important for facial masks that need to maintain their effects for a long time. This film can also reduce the evaporation or loss of other active ingredients from the skin, ensuring that they can work for a longer period of time. Cyclopentasiloxane can help dissolve and carry other oils or solid ingredients that are not easily soluble in water, allowing these ingredients to be better integrated into the formula and helping their distribution on the skin. It can indirectly help active ingredients cover the skin more evenly by improving the rheology and spreadability of the product, thereby potentially improving absorption efficiency.

[0037] Squalane has excellent skin affinity and can quickly penetrate into the surface of the skin, replenish the oils needed by the skin, and form a protective film to lock in moisture and prevent moisture loss. It helps to restore and strengthen the skin's natural barrier and is particularly suitable for dry, sensitive skin and skin damaged by environmental factors. Squalane can neutralize free radicals produced in the body, reduce oxidative stress on the skin caused by ultraviolet radiation and other external factors, and delay the aging process. By providing the necessary lipid support, squalane promotes the production of healthy skin cells and helps improve signs of aging such as fine lines and wrinkles. Squalane has certain anti-inflammatory properties and the ability to accelerate wound healing.

[0038] Cetearyl alcohol can significantly increase the viscosity of facial masks, giving them a thicker texture that is easier to apply and spread evenly. As an emulsifier or co-emulsifier, it improves the compatibility between the oil and water phases, prevents product stratification, and ensures the long-term stability of the formula. By replenishing the skin's natural lipids, it helps repair and strengthen the skin barrier, making it particularly suitable for dry and sensitive skin. It can form a lubricating layer on the skin, reducing friction and thus avoiding unnecessary pulling or damage to the skin. Cetearyl alcohol can quickly form a thin and long-lasting protective film, which not only helps keep the skin moisturized, but also enhances the effects of other active ingredients. The film it forms has a certain degree of water resistance, which can help prevent external pollutants and moisture from invading the skin.

[0039] Palm kernel oil is rich in saturated fatty acids, such as lauric acid and myristic acid, which can quickly penetrate into the surface of the skin, replenish the lipids needed by the skin, and form a protective film to lock in moisture. Palm kernel oil is rich in vitamin E and other natural antioxidants, such as carotenoids, which can neutralize free radicals, reduce oxidative damage to the skin caused by ultraviolet radiation and other external factors, and slow down the aging process. Palm kernel oil helps promote the production of healthy skin cells and helps improve signs of aging such as fine lines and wrinkles. Palm kernel oil has good emulsification ability, which can help remove aging keratin cells and dirt on the surface of the skin, but will not excessively deprive the skin of its natural oils, maintaining the water and oil balance of the skin.

[0040] Caprylic / capric triglyceride can quickly penetrate into the surface of the skin, replenish the lipids needed by the skin, help lock in moisture and prevent moisture loss. Caprylic / capric triglyceride can improve the compatibility between different ingredients, ensure that the various active ingredients in the mask cream are evenly distributed, and improve the overall stability and consistency of the product.

[0041] Cetearyl alcohol can significantly increase the viscosity of the mask cream, making it thicker and easier to spread and distribute evenly. It can improve the compatibility between the oil phase and the water phase, prevent product stratification, and ensure the long-term stability of the formula.

[0042] Fucose has good hygroscopicity and can attract and lock in moisture, helping the skin stay hydrated. It can form a moisturizing film on the skin surface to prevent moisture loss. By replenishing the polysaccharide components needed by the skin, fucose helps repair and strengthen the skin barrier and improve the skin's ability to retain water. Fucose may stimulate the activity of fibroblasts and promote the production of collagen and elastic fibers, thereby delaying the skin's aging process and improving fine lines and wrinkles.

[0043] The present invention has at least the following beneficial effects:

[0044] The Chinese medicine composition for removing acne provided by the present invention can play the role of clearing away heat and detoxification, reducing swelling and dispersing knots, antibacterial, anti-inflammatory and whitening after the six Chinese medicines are matched. Among them, Forsythia suspensa is the main drug, which plays the role of killing Propionibacterium acnes, Taraxacum officinale and Viola yedoensis are the assistant drugs, which play the role of anti-inflammatory and antioxidant, Portulaca oleracea is the adjuvant, which plays the role of antibacterial, anti-inflammatory, exfoliation and repairing stratum corneum, Bletilla striata and Paeonia lactiflora are the guiding drugs, which play the role of anti-oxidative stress and improving blood circulation; the Chinese medicine facial mask cream provided by the present invention can promote the absorption of Chinese medicine ingredients, and also has good moisturizing, film-forming and anti-aging properties. DETAILED DESCRIPTION

[0045] In order to make the purpose, method scheme and advantages of the embodiments of the present invention clearer, the method scheme in the embodiments of the present invention is clearly and completely described. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments.

[0046] Embodiment 1: A Chinese medicine composition for acne removal, comprising the following components, by weight: 80 parts of Bletilla striata, 105 parts of Red Peony Root, 120 parts of Portulaca Oleracea, 110 parts of Taraxacum Officinale, 90 parts of Viola Yedoensis, and 115 parts of Forsythia suspensa.

[0047] Example 2: A Chinese medicine composition for acne removal, comprising the following components, in parts by weight: 170 parts of Bletilla striata, 210 parts of Red Peony Root, 265 parts of Portulaca Oleracea, 230 parts of Taraxacum Officinale, 210 parts of Viola Yedoensis, and 310 parts of Forsythia suspensa.

[0048] Example 3: A Chinese medicine composition for acne removal, comprising the following components, in parts by weight: 160 parts of Bletilla striata, 160 parts of Red Peony Root, 200 parts of Portulaca Oleracea, 180 parts of Taraxacum Officinale, 185 parts of Viola Yedoensis, and 200 parts of Forsythia suspensa.

[0049] Embodiment 4: A method for preparing a Chinese medicine composition for acne treatment, comprising:

[0050] S100, all the medicinal materials are decocted with water once, 10 times the amount of water is added, and the mixture is extracted for 1 hour to obtain a dissolution liquid and a dissolution material;

[0051] S200, boiling the first dissolved material for a second time, adding 8 times the amount of water, extracting for 30 minutes, and obtaining a second dissolved solution; combining the first dissolved solution and the second dissolved solution to obtain a mixed solution;

[0052] S300, the mixed solution is filtered, centrifuged and concentrated to obtain a Chinese medicine composition for acne removal with a relative density of 1.16 g / mL, the centrifugal rate is 3000 r / min, and the centrifugal time is 10 min.

[0053] Embodiment 5: A method for preparing a Chinese medicine composition for acne treatment, comprising:

[0054] S100, adding Bletilla striata and Paeonia lactiflora to water and decocting once to obtain a first decoction liquid and a first decoction material; the decoction temperature is 75° C., the material-liquid ratio is 1:12, and the decoction time is 100 min;

[0055] Purslane, dandelion, Viola yedoensis and Forsythia suspensa are added to ethanol, heated in a water bath, and then the ethanol is recovered by a rotary evaporator to obtain a first extract and an extracted material. The water bath temperature is 80°C, the material-liquid ratio is 1:18, the water bath time is 1.5h, and the ethanol concentration is 70%.

[0056] S200, the S200 comprises: adding water to the first decoction material and boiling it twice to obtain a second decoction liquid, the boiling temperature is 75° C., the boiling time is 50 min, and the first decoction liquid and the second decoction liquid are combined to obtain a first medicinal liquid;

[0057] The extracted material is added to ethanol, heated in a water bath, and the ethanol is recovered by a rotary evaporator to obtain a second extract. The water bath temperature is 80° C., the water bath time is 0.8 h, and the ethanol concentration is 70%. The first extract and the second extract are combined to obtain a second drug solution;

[0058] The first liquid medicine and the second liquid medicine are combined to obtain the mixed solution.

[0059] S300, the mixed solution is filtered, centrifuged and concentrated to obtain a Chinese medicine composition for acne removal with a relative density of 1.16 g / mL, the centrifugal rate is 3000 r / min, and the centrifugal time is 10 min.

[0060] Embodiment 6: A method for preparing a Chinese medicine composition for acne treatment, comprising:

[0061] S100, adding Bletilla striata and Paeonia lactiflora to water and decocting once to obtain a first decoction liquid and a first decoction material; the decoction temperature is 85° C., the material-liquid ratio is 1:10, and the decoction time is 140 min;

[0062] Purslane, dandelion, Viola yedoensis and Forsythia suspensa are added to ethanol, heated in a water bath, and then the ethanol is recovered by a rotary evaporator to obtain a first extract and an extracted material. The water bath temperature is 100°C, the material-liquid ratio is 1:15, the water bath time is 2.5h, and the ethanol concentration is 85%.

[0063] S200, the S200 comprises: adding water to the first decoction material and boiling it twice to obtain a second decoction liquid, the boiling temperature is 85° C., the boiling time is 70 min, and the first decoction liquid and the second decoction liquid are combined to obtain a first medicinal liquid;

[0064] The extracted material is added to ethanol, heated in a water bath, and the ethanol is recovered by a rotary evaporator to obtain a second extract. The water bath temperature is 100° C., the water bath time is 1.2 h, and the ethanol concentration is 85%. The first extract and the second extract are combined to obtain a second drug solution;

[0065] The first liquid medicine and the second liquid medicine are combined to obtain the mixed solution.

[0066] S300, the mixed solution is filtered, centrifuged and concentrated to obtain a Chinese medicine composition for acne removal with a relative density of 1.16 g / mL, the centrifugal rate is 3000 r / min, and the centrifugal time is 10 min.

[0067] Embodiment 7: A method for preparing a Chinese medicine composition for acne treatment, comprising:

[0068] S100, adding Bletilla striata and Paeonia lactiflora to water and decocting once to obtain a first decoction liquid and a first decoction material; the decoction temperature is 80° C., the material-liquid ratio is 1:10, and the decoction time is 120 min;

[0069] Purslane, dandelion, Viola yedoensis and Forsythia suspensa are added to ethanol, heated in a water bath, and then the ethanol is recovered by a rotary evaporator to obtain a first extract and an extracted material. The water bath temperature is 90°C, the material-liquid ratio is 1:15, the water bath time is 2 hours, and the ethanol concentration is 80%.

[0070] S200, the S200 comprises: adding water to the first decoction material and boiling it twice to obtain a second decoction liquid, the boiling temperature is 80° C., the boiling time is 60 min, and the first decoction liquid and the second decoction liquid are combined to obtain a first medicinal liquid;

[0071] The extracted material is added to ethanol, heated in a water bath, and the ethanol is recovered by a rotary evaporator to obtain a second extract. The water bath temperature is 90° C., the water bath time is 1 hour, and the ethanol concentration is 80%. The first extract and the second extract are combined to obtain a second drug solution;

[0072] The first liquid medicine and the second liquid medicine are combined to obtain the mixed solution.

[0073] S300, the mixed solution is filtered, centrifuged and concentrated to obtain a Chinese medicine composition for acne removal with a relative density of 1.16 g / mL, the centrifugal rate is 3000 r / min, and the centrifugal time is 10 min.

[0074] Embodiment 8: A method for preparing a Chinese medicine composition for acne treatment, comprising:

[0075] S100, drying the bletilla striata and red peony root in a hot constant temperature blast drying oven at 60° C. to a water content of 12%, crushing them with a traditional Chinese medicine grinder, and passing them through a 20-mesh sieve to obtain drug granules, adding water to the bletilla striata granules and the red peony root granules to decoct them once to obtain a first decoction liquid and a first decoction material; the decoction temperature is 80° C., the material-liquid ratio is 1:10, and the decoction time is 120 min;

[0076] Take purslane, dandelion, viola yedoensis and forsythia, place them in an oven at 65°C and dry them to a moisture content of 12%, take out the dried medicinal materials and crush them with a grinder for 2 to 3 times, and finally pass them through a 60-mesh sieve to obtain medicinal powder, add purslane powder, dandelion powder, viola yedoensis powder and forsythia powder to ethanol, heat them in a water bath, and recover ethanol through a rotary evaporator to obtain a first extract and an extracted material, the water bath temperature is 90°C, the solid-liquid ratio is 1:15, the water bath time is 2h, and the ethanol concentration is 80%.

[0077] S200, the S200 comprises: adding water to the first decoction material and boiling it twice to obtain a second decoction liquid, the boiling temperature is 80° C., the boiling time is 60 min, and the first decoction liquid and the second decoction liquid are combined to obtain a first medicinal liquid;

[0078] The extracted material is added to ethanol, heated in a water bath, and the ethanol is recovered by a rotary evaporator to obtain a second extract. The water bath temperature is 90° C., the water bath time is 1 hour, and the ethanol concentration is 80%. The first extract and the second extract are combined to obtain a second drug solution;

[0079] The first liquid medicine and the second liquid medicine are combined to obtain the mixed solution.

[0080] S300, the mixed solution is filtered, centrifuged and concentrated to obtain a Chinese medicine composition for acne removal with a relative density of 1.16 g / mL, the centrifugal rate is 3000 r / min, and the centrifugal time is 10 min.

[0081] Example 9: A Chinese medicine facial mask cream, comprising, by weight: 522 parts of a Chinese medicine composition for removing acne, 0.075 parts of sodium hyaluronate, 36 parts of honey, 36.12 parts of propylene glycol, 36.12 parts of glycerin, 18.06 parts of cyclopentasiloxane, 10.83 parts of squalane, 7.22 parts of cetearyl alcohol, 7.22 parts of elaeis guineensis kernel oil, 5.42 parts of polydimethylsiloxane, 5.42 parts of caprylic / capric triglyceride, 4.33 parts of cetearyl alcohol, 0.72 parts of fucose, and 168.54 parts of water.

[0082] Test Example 1: A Chinese medicine facial mask cream, in parts by weight, includes: 522g of Chinese medicine composition for acne removal, 0.075g of sodium hyaluronate, 36g of honey, 36.12g of propylene glycol, 36.12g of glycerol, 18.06g of cyclopentasiloxane, 10.83g of squalane, 7.22g of cetearyl alcohol, 7.22g of elaeis guineensis kernel oil, 5.42g of polydimethylsiloxane, 5.42g of caprylic / capric triglyceride, 4.33g of cetearyl alcohol, 0.72g of fucose, and 168.54g of water. The above components are mixed and stirred evenly to obtain a Chinese medicine facial mask cream.

[0083] Among them, the Chinese medicine composition for acne removal is prepared by using the component ratio of Example 3 and the preparation method of Example 4.

[0084] Experimental Example 2: The difference from Experimental Example 1 is that the anti-acne Chinese medicine composition is prepared by using the component proportions of Example 3 and the preparation method of Example 5.

[0085] Test Example 3: The difference from Test Example 1 is that the anti-acne Chinese medicine composition is prepared by using the component proportions of Example 3 and the preparation method of Example 6.

[0086] Test Example 4: The difference from Test Example 1 is that the anti-acne Chinese medicine composition is prepared by using the component proportions of Example 3 and the preparation method of Example 7.

[0087] Test Example 5: The difference from Test Example 1 is that the anti-acne Chinese medicine composition is prepared by using the component proportions of Example 3 and the preparation method of Example 8.

[0088] Safety evaluation

[0089] 1. Rat skin irritation test

[0090] (1) Animal grouping and modeling

[0091] Sixteen Wistar rats were randomly divided into two groups according to gender and weight, namely, intact skin group and damaged skin group. 24 hours before applying the Chinese medicine anti-acne mask, the two groups of rats were depilated on both sides of the spine, and the depilated area was about 3cm×3cm on each side. Among them, the damaged skin group was disinfected with 75% ethanol in the depilated area, and then the skin was scratched in a letter shape with a disposable sterile needle. The laceration was about 3cm horizontally and vertically, and the degree of oozing of small blood beads was considered the same. The experiment adopted the self-control method. The mask cream on the left depilated area was covered with pearlescent film and fixed with medical non-woven fabric. The right depilated area was used as a blank control. The test substance was applied for 4 hours a day, once a day, for 7 consecutive days. Observe and record the presence of erythema and edema in the application site 1 hour after wiping off the mask cream with pure water and before applying it again. Observe the application site for erythema and edema 1, 24, 48, and 72 hours after the last application and removal of the test substance, and give scores according to the scoring criteria and judge the intensity of stimulation according to the intensity criteria.

[0092] (2) Evaluation of skin irritation intensity

[0093] The presence of erythema and edema at the application site was scored according to the "Skin Irritation Reaction Scoring Standards", the average score of each group of rats was calculated, and the irritation intensity was evaluated. The "Skin Irritation Reaction Scoring Standards" are shown in Table 1, and the "Skin Irritation Intensity Evaluation Standards" are shown in Table 2.

[0094] Table 1 Skin irritation response scoring criteria

[0095]

[0096] Table 2 Evaluation criteria for skin irritation intensity

[0097] Points evaluate 0—0.49 Non-irritating 0.5—2.99 Mild irritant 3.0—5.99 Moderate irritation 6.0—8.00 Severe irritation

[0098] (3) Experimental results

[0099] Rats in the intact skin group and damaged skin group did not show obvious erythema or edema at the application site, indicating that the Chinese medicine anti-acne mask cream had no irritation to the skin (see Table 3).

[0100] Table 3 Results of the rat skin irritation test of Chinese medicine mask cream

[0101]

[0102] It can be seen from the test results of Test Examples 1-5 that the Chinese medicine facial mask cream provided by the present invention is non-irritating.

[0103] 2. Guinea pig skin allergy test

[0104] (1) Animal grouping and modeling

[0105] Guinea pigs were randomly divided into 3 groups according to gender and weight: blank matrix group, positive control group (2,4-dinitrochlorobenzene, prepared with 75% ethanol to a concentration of 1%), and Chinese medicine anti-acne mask group, with 6 animals in each group. The hair on both sides of the guinea pigs' backs was removed 24 hours before application, and the hair removal area on each side was about 3cm×3cm. Sensitization contact: Apply the mask cream to the hair removal area on the left side, with an area of ​​3cm×3cm, cover it with a pearlescent film, fix it with a medical non-woven patch, and remove it after 6 hours. Repeat once on the 7th and 14th days, for a total of 3 times. The blank matrix group and the positive control group were sensitized in the same way. Provocative contact: Apply the mask cream to the hair removal area on the right side 14 days after the last application of the mask cream. Remove it after 6 hours, observe immediately, and observe the skin allergic reaction at 24, 48, and 72 hours. Provocative contact and observation were performed in the same way in the blank matrix group and the positive control group.

[0106] (2) Evaluation of skin sensitization

[0107] The presence or absence of erythema and edema at the application site was scored according to the "Skin Allergy Reaction Scoring Standard". The sensitization incidence was calculated according to the formula and the skin sensitization evaluation was performed. Sensitization incidence = (number of guinea pig skin allergy reaction scores / total number of guinea pigs tested) × 100%. See Table 4 for the "Skin Allergy Reaction Scoring Standard" and Table 5 for the "Skin Sensitization Evaluation Standard".

[0108] Table 4 Scoring criteria for skin allergic reaction

[0109]

[0110] Table 5 Evaluation criteria for skin sensitization

[0111] Sensitization incidence (%) Skin sensitization evaluation 0—10 Non-allergenic 11—30 Mild allergenicity 31—60 Moderate sensitization 61—80 Severe allergenicity 81—100 Extremely allergenic

[0112] (3) Experimental results

[0113] After 6 hours of 2,4-dinitrochlorobenzene stimulation, guinea pigs showed varying degrees of erythema or edema on their skin, which worsened over time and reached a peak at 48 hours. No obvious erythema or edema was observed on the skin of the guinea pigs in the blank matrix group and the mask cream group at 6, 24, 48, and 72 hours of stimulation. Compared with the positive control group, the skin allergy scores of the blank matrix group and the mask cream group were reduced at each time point, and the difference was statistically significant (P<0.01). This shows that the Chinese medicine anti-acne mask cream has no sensitization to guinea pigs (the results are shown in Table 6).

[0114] Table 6 Guinea pig skin allergy test results of Chinese medicine anti-acne mask cream

[0115]

[0116] Compared with the positive control group, *P<0.05, **P<0.01

[0117] It can be seen from the test results of Test Examples 1-5 that the Chinese medicine facial mask cream provided by the present invention is non-allergenic.

[0118] 3. Effect test of Chinese medicine mask cream

[0119] 100 volunteers with acne on their faces were selected, with an age distribution of 18-30 years old, and randomly divided into five groups A, B, C, D, and E, with 20 people in each group. Group A applied the Chinese medicine mask cream prepared in Test Example 1, Group B applied the Chinese medicine mask cream prepared in Test Example 2, Group C applied the Chinese medicine mask cream prepared in Test Example 3, Group D applied the Chinese medicine mask cream prepared in Test Example 4, and Group E applied the Chinese medicine mask cream prepared in Test Example 5. Usage: Take 3g each time and apply it on the face for 20 minutes before removing it, once every night, once every other day, for a total of 20 days, and apply it 10 times.

[0120] The Pillsburg four-level modified grading method was used to evaluate the efficacy: Grade I (mild), the main skin lesions were blackheads, scattered or multiple, inflammatory papules scattered, and the total number of lesions was 10-30; Grade II (moderate), the main skin lesions were acne, and there were a moderate number of papules and potential pustules, the total number of lesions was 31-50, and it was confined to the face; Grade III (moderate), the main skin lesions were deep inflammatory papules and pustules, the total number of lesions was 51-100, the number of nodules was less than 3, and it occurred on the face, neck, chest and back; Grade IV (severe), the main skin lesions were deep inflammatory papules and pustules, the total number of lesions was greater than 100, the number of nodules or cysts was greater than 3, and it was easy to form scars, and it occurred on the upper body. The efficacy was evaluated by the average number of total lesions before and after treatment of each sample and the effective rate. The effective rate refers to the percentage of individuals with a reduction of more than 40% in the number of lesions in the total number of people. The results are shown in Table 7.

[0121] Table 7

[0122]

[0123]

[0124] It can be seen from the test results of Test Examples 1-5 that, after treatment, the acne grade of the volunteers was changed from grade II to grade I, and the Chinese medicine mask cream provided by the present invention has a good acne-removing effect.

[0125] From the comparison of the results of Experimental Example 1 and Experimental Examples 2-4, it can be seen that the batch and method extraction of the active ingredients of the medicinal materials can improve the acne-removing effect of the facial mask.

[0126] From the comparison of the results of Experimental Example 4 and Experimental Example 5, it can be seen that the pretreatment process of the medicinal materials: drying and crushing, helps to improve the acne-removing effect of the mask cream.

[0127] The above are only preferred embodiments of the present invention and are not intended to limit the present invention. For those skilled in the art, the present invention may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A Chinese medicine composition for acne treatment, characterized in that: The invention comprises the following components in parts by weight: 80-170 parts of bletilla striata, 105-210 parts of red peony root, 120-265 parts of purslane, 110-230 parts of dandelion, 90-210 parts of viola yedoensis and 115-310 parts of forsythia.

2. A Chinese medicine composition for acne treatment according to claim 1, characterized in that: The invention comprises the following components in parts by weight: 160 parts of bletilla striata, 160 parts of red peony root, 200 parts of purslane, 180 parts of dandelion, 185 parts of viola yedoensis and 200 parts of forsythia.

3. A method for preparing the acne-removing Chinese medicine composition according to claim 1 or 2, characterized in that: include: S100, dissolving and extracting all medicinal materials once to obtain a dissolution solution and a dissolved material; the material-liquid ratio of medicinal materials to solvent is 1:18-1:10; S200, performing secondary dissolution extraction on the material after the primary dissolution to obtain a secondary dissolution liquid; the material-liquid ratio of the medicinal material to the solvent is 1:9-1:7; combining the primary dissolution liquid and the secondary dissolution liquid to obtain a mixed solution; S300, filtering, centrifuging and concentrating the mixed solution to obtain a Chinese medicine composition for acne removal.

4. The preparation method according to claim 3, characterized in that: The S100 includes: Adding Bletilla striata and Paeonia lactiflora to water and decocting once to obtain a first decoction liquid and a first decoction material; the decoction temperature is 75-85° C., the material-liquid ratio is 1:12-1:10, and the decoction time is 100-140 minutes; Add purslane, dandelion, Viola yedoensis and Forsythia suspensa to ethanol, evaporate the ethanol after heating in a water bath to obtain a first extract and a post-extract material, the water bath temperature is 80-100°C, the material-liquid ratio is 1:18-1:15, the water bath time is 1.5-2.5h, and the ethanol concentration is 70%-85%.

5. The preparation method according to claim 4, characterized in that: Before decocting once, the white striata and red peony root are dried and crushed to form medicine granules, the drying temperature is 50-60 DEG C, the particle size of the medicine granules is ≤20 mesh, and the water content of the medicine granules is 10%-12%.

6. The preparation method according to claim 4, characterized in that: Before adding ethanol, purslane, dandelion, Viola yedoensis and forsythia are dried and crushed to form drug particles, the drying temperature is 65-70 DEG C, the particle size of the drug particles is 50-60 meshes, and the water content of the drug particles is 10%-12%.

7. The preparation method according to any one of claims 4 to 6, characterized in that: The step S200 comprises: adding water to the first decoction material and boiling it twice to obtain a second decoction liquid, wherein the boiling temperature is 75-85° C. and the boiling time is 50-70 min, and the first decoction liquid and the second decoction liquid are combined to obtain a first medicinal liquid; The extracted material is added to ethanol, and the ethanol is evaporated after heating in a water bath to obtain a second extract, the water bath temperature is 80-100°C, the water bath time is 0.8-1.2h, the ethanol concentration is 70%-85%, and the first extract and the second extract are combined to obtain a second drug solution; The first liquid medicine and the second liquid medicine are combined to obtain the mixed solution.

8. The preparation method according to claim 7, characterized in that: The centrifugal speed in the S300 is 250-350 r / min, and the centrifugal time is 8-12 min.

9. The preparation method according to claim 7, characterized in that: The relative density of the acne-removing Chinese medicinal composition is 1.05-1.25 g / ml.

10. A Chinese medicine facial mask cream, characterized in that: The invention comprises, by weight, 500-550 parts of a Chinese herbal composition for removing acne, 0.06-0.08 parts of sodium hyaluronate, 30-40 parts of honey, 33-38 parts of propylene glycol, 33-38 parts of glycerol, 15-20 parts of cyclopentasiloxane, 8-12 parts of squalane, 6-8 parts of cetearyl alcohol, 6-8 parts of elaeis guineensis kernel oil, 4-6 parts of polydimethylsiloxane, 4-6 parts of caprylic / capric triglyceride, 3-5 parts of cetearyl alcohol, 0.6-0.8 parts of fucose and 150-180 parts of water; the Chinese herbal composition for removing acne is prepared by the preparation method according to any one of claims 3 to 9.

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