Formula and preparation method of central venous catheter coating

Abstract

The invention discloses a central venous catheter coating formula and a preparation method thereof.The coating comprises a bottom coating and a top coating, the top coating covers the bottom coating, and the bottom coating comprises, by weight, 50-60 parts of a primer, 1.5-2 parts of a cross-linking agent A, 25-30 parts of ethyl alcohol and 25-30 parts of purified water; the formula of the top-layer coating comprises 100-120 parts by weight of a top coating agent, 1-3 parts by weight of a cross-linking agent B and 100-200 parts by weight of purified water, and the formula of the bottom-layer coating and the formula of the top-layer coating are anti-sticking, hydrophilic and lubricating; the bottom coating has the effect of enhancing adhesive force and is firmly bonded with the base material, and the top coating is combined with the bottom coating through temperature crosslinking, has hydrophilic lubrication and anticoagulation functions and is firmly combined with the base material of the central venous catheter to form the coating with good biocompatibility and antithrombotic effect.

Description

Technical Field

[0001] The invention relates to the technical field of medical equipment, and in particular to a central venous catheter coating formula and a preparation method. Background Art

[0002] Central venous catheters are mainly medical devices made of polyurethane or silicone. They are usually punctured and placed in the subclavian vein, internal jugular vein, and basilic vein for the treatment of patients undergoing surgery or chemotherapy. Central venous catheters are divided into many models, including single-lumen, double-lumen, and triple-lumen central venous catheters. In clinical practice, they are commonly used in departments such as emergency, ICU, anesthesia, and hemodialysis. Central venous catheters are also widely used. They can measure central venous pressure to evaluate the amount of fluid replacement. For malnourished patients, they can be used as a route for long-term parenteral nutrition. When major surgery is performed with a lot of bleeding, a large amount of rapid intravenous infusion can be given through the central venous catheter to maintain blood pressure. Patients with uremia often undergo hemodialysis as a blood route. Tumor patients undergoing chemotherapy can use central venous catheters to infuse tumor chemotherapy drugs to prevent the occurrence of phlebitis. Therefore, central venous catheters are an important auxiliary treatment material in clinical medicine.

[0003] Deficiencies of existing technology: Currently, when a central venous catheter enters the body, the blood compatibility of the material has a significant impact on the patient, and blood clots will form on the surface over a certain period of time. Applying drugs on the surface is a convenient method, but the drugs have certain side effects on the human body, and there is also the problem of weak bonding between the drugs and the catheter. Summary of the invention

[0004] The purpose of the present invention is to provide a central venous catheter coating formulation and preparation method to solve the problems raised in the above background technology.

[0005] To achieve the above-mentioned purpose, the present invention provides the following technical scheme: a central venous catheter coating formula, the coating comprising a bottom coating and a top coating, the top coating being laminated on the bottom coating, the bottom coating formula comprising 50-60 parts by weight of a primer, 1.5-2 parts by weight of a cross-linking agent A, 25-30 parts by weight of ethanol and 25-30 parts by weight of purified water; the top coating formula comprising 100-120 parts by weight of a top coating agent, 1-3 parts by weight of a cross-linking agent B and 100-200 parts by weight of purified water, the bottom coating formula and the top coating formula both being anti-adhesive, hydrophilic and lubricating.

[0006] Preferably, the central venous catheter is made of polyurethane or silicone.

[0007] The present invention also provides a method for preparing a central venous catheter coating formulation, and the preparation method specifically comprises the following steps: S1, complete the bottom coating; S2. Complete the top coating.

[0008] Preferably, the step S1 specifically includes the following steps: a1. Evenly mix 25-30 parts by weight of ethanol and 25-30 parts by weight of purified water; a2. Slowly add 50-60 parts by weight of primer and vibrate to mix evenly, then slowly add 1.5-2 parts by weight of crosslinking agent A and vibrate to mix for 5 minutes; a3. Coat the central venous catheter with the base coating by immersion; a4. Place the coated central venous catheter in a constant temperature drying oven to dry.

[0009] Preferably, the step S2 specifically includes the following steps: b1. Add 100-200 parts by weight of purified water to 1-3 parts by weight of crosslinking agent B and mix by vibration. Then slowly add 100-120 parts by weight of top coating agent and mix by vibration for 5 minutes. b2. Coat the central venous catheter with the top coating by immersion, and place the central venous catheter in a constant temperature drying oven to dry.

[0010] Preferably, in step a4, the constant temperature drying oven is set to 65° C. for drying for 30 minutes or 70° C. for drying for 15 minutes.

[0011] Preferably, in step b2, the constant temperature drying oven is set to 65° C. for drying for 120 minutes or 70° C. for drying for 90 minutes.

[0012] Preferably, the steps a1 and a2 are configured and used within one hour.

[0013] Preferably, the step b2 is used within one hour after configuration.

[0014] Compared with the prior art, the present invention has the following beneficial effects: The present invention discloses a central venous catheter coating formula and a preparation method thereof. The bottom coating has the function of enhancing adhesion, and the coating is firmly bonded to a substrate. The top coating is combined with the bottom coating by temperature cross-linking, has hydrophilic lubrication and anticoagulation functions, and is firmly combined with a central venous catheter base material to form a coating with good biocompatibility and anti-thrombotic effect. DETAILED DESCRIPTION

[0015] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0016] In the description of the present invention, it is necessary to understand that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise" and the like indicate orientations or positional relationships, which are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present invention.

[0017] In the description of this patent, it should be noted that, unless otherwise clearly specified and limited, the terms "installation", "connection" and "setting" should be understood in a broad sense, for example, it can be fixed connection, setting, or detachable connection, setting, or integrated connection, setting. For ordinary technicians in this field, the specific meanings of the above terms in this patent can be understood according to specific circumstances.

[0018] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of the features. In the description of the present invention, the meaning of "several" is two or more, unless otherwise clearly and specifically defined.

[0019] Example 1 The present invention provides a central venous catheter coating formula and a technical solution for preparing the same: the coating comprises a bottom coating and a top coating, the top coating is laminated on the bottom coating, the bottom coating comprises 50-60 parts by weight of a primer, 1.5-2 parts by weight of a cross-linking agent A, 25-30 parts by weight of ethanol and 25-30 parts by weight of purified water; the top coating comprises 100-120 parts by weight of a top coating, 1-3 parts by weight of a cross-linking agent B and 100-200 parts by weight of purified water, the bottom coating and the top coating are both anti-adhesive, hydrophilic and lubricating, and the central venous catheter is made of polyurethane or silicone.

[0020] This preparation method specifically comprises the following steps: S1, complete the bottom coating; a1. Mix 28 parts by weight of ethanol and 28 parts by weight of purified water; a2. Slowly add 55 parts by weight of primer and vibrate to mix evenly, then slowly add 1.8 parts by weight of cross-linking agent A and vibrate to mix for 5 minutes. Use within one hour after preparation. a3. Coat the central venous catheter with the base coating by immersion; a4. Place the coated central venous catheter in a constant temperature drying oven and set the constant temperature drying oven to 65°C for 30 minutes or 70°C for 15 minutes.

[0021] S2, top coating is completed; b1. Add 110 parts by weight of purified water to 2 parts by weight of crosslinking agent B and mix by vibration. Then slowly add 110 parts by weight of top coating agent and mix by vibration for 5 minutes. Use within one hour after preparation. b2. Coat the central venous catheter with a top coating by immersion, and place the central venous catheter in a constant temperature drying oven for drying. The constant temperature drying oven is set to 65°C for drying for 120 minutes or 70°C for drying for 90 minutes.

[0022] Comparative Example 1 Follow these steps: S1, complete the bottom coating; a1. Mix 20 parts by weight of ethanol and 20 parts by weight of purified water; a2. Slowly add 40 parts by weight of primer and vibrate to mix evenly, then slowly add 1.0 parts by weight of cross-linking agent A and vibrate to mix for 5 minutes. Use within one hour after preparation. a3. Coat the central venous catheter with the base coating by immersion; a4. Place the coated central venous catheter in a constant temperature drying oven and set the constant temperature drying oven to 65°C for 30 minutes or 70°C for 15 minutes.

[0023] S2, top coating is completed; b1. Add 2 parts by weight of cross-linking agent B to 100 parts by weight of purified water and mix by vibration. Then slowly add 110 parts by weight of top coating agent and mix by vibration for 5 minutes. Use within one hour after preparation. b2. Coat the central venous catheter with a top coating by immersion, and place the central venous catheter in a constant temperature drying oven for drying. The constant temperature drying oven is set to 65°C for drying for 120 minutes or 70°C for drying for 90 minutes.

[0024] Comparative Example 2 Follow these steps: S1, complete the bottom coating; a1. Mix 35 parts by weight of ethanol and 35 parts by weight of purified water; a2. Slowly add 65 parts by weight of primer and vibrate to mix evenly, then slowly add 3 parts by weight of crosslinking agent A and vibrate to mix for 5 minutes. Use within one hour after preparation. a3. Coat the central venous catheter with the base coating by immersion; a4. Place the coated central venous catheter in a constant temperature drying oven and set the constant temperature drying oven to 65°C for 30 minutes or 70°C for 15 minutes.

[0025] S2. Complete the top coating.

[0026] b1. Add 2 parts by weight of cross-linking agent B to 100 parts by weight of purified water and mix by vibration. Then slowly add 110 parts by weight of top coating agent and mix by vibration for 5 minutes. Use within one hour after preparation. b2. Coat the central venous catheter with a top coating by immersion, and place the central venous catheter in a constant temperature drying oven for drying. The constant temperature drying oven is set to 65°C for drying for 120 minutes or 70°C for drying for 90 minutes.

[0027] Comparative Example 3 Follow these steps: S1, complete the bottom coating; a1. Mix 28 parts by weight of ethanol and 28 parts by weight of purified water; a2. Slowly add 55 parts by weight of primer and vibrate to mix evenly, then slowly add 1.8 parts by weight of cross-linking agent A and vibrate to mix for 5 minutes. Use within one hour after preparation. a3. Coat the central venous catheter with the base coating by immersion; a4. Place the coated central venous catheter in a constant temperature drying oven and set the constant temperature drying oven to 65°C for 30 minutes or 70°C for 15 minutes.

[0028] S2, top coating is completed; b1. Add 0.5 parts by weight of cross-linking agent B to 90 parts by weight of purified water and mix by vibration. Then slowly add 90 parts by weight of top coating agent and mix by vibration for 5 minutes. Use within one hour after preparation. b2. Coat the central venous catheter with a top coating by immersion, and place the central venous catheter in a constant temperature drying oven for drying. The constant temperature drying oven is set to 65°C for drying for 120 minutes or 70°C for drying for 90 minutes.

[0029] Comparative Example 4 Follow these steps: S1, complete the bottom coating; a1. Mix 28 parts by weight of ethanol and 28 parts by weight of purified water; a2. Slowly add 55 parts by weight of primer and vibrate to mix evenly, then slowly add 1.8 parts by weight of cross-linking agent A and vibrate to mix for 5 minutes. Use within one hour after preparation. a3. Coat the central venous catheter with the base coating by immersion; a4. Place the coated central venous catheter in a constant temperature drying oven and set the constant temperature drying oven to 65°C for 30 minutes or 70°C for 15 minutes.

[0030] S2, top coating is completed; b1. Add 130 parts by weight of purified water to 4 parts by weight of cross-linking agent B and mix by vibration. Then slowly add 130 parts by weight of top coating agent and mix by vibration for 5 minutes. Use within one hour after preparation. b2. Coat the central venous catheter with a top coating by immersion, and place the central venous catheter in a constant temperature drying oven for drying. The constant temperature drying oven is set to 65°C for drying for 120 minutes or 70°C for drying for 90 minutes.

[0031] According to Example 1, compared with Comparative Examples 1, 2, 3 and 4, the formula of the bottom coating layer includes 50-60 parts by weight of a primer, 1.5-2 parts by weight of a cross-linking agent A, 25-30 parts by weight of ethanol and 25-30 parts by weight of purified water; the formula of the top coating layer includes 100-120 parts by weight of a top coating agent, 1-3 parts by weight of a cross-linking agent B and 100-200 parts by weight of purified water as the best solution.

[0032] The above shows and describes the basic principles, main features and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited by the above embodiments. The above embodiments and descriptions are only preferred examples of the present invention and are not intended to limit the present invention. Without departing from the spirit and scope of the present invention, the present invention may have various changes and improvements, which fall within the scope of the present invention. The scope of protection of the present invention is defined by the attached claims and their equivalents.

Claims

1. A central venous catheter coating formulation, characterized in that: The coating comprises a bottom coating and a top coating, wherein the top coating is laminated on the bottom coating, wherein the bottom coating comprises 50 to 60 parts by weight of a primer, 1.5 to 2 parts by weight of a cross-linking agent A, 25 to 30 parts by weight of ethanol and 25 to 30 parts by weight of purified water; wherein the top coating comprises 100 to 120 parts by weight of a top coating, 1 to 3 parts by weight of a cross-linking agent B and 100 to 200 parts by weight of purified water, and both the bottom coating and the top coating have anti-stick, hydrophilic and lubricating properties.

2. A central venous catheter coating formulation according to claim 1, characterized in that: The central venous catheter is made of polyurethane or silicone catheter.

3. A method for preparing a central venous catheter coating formulation according to any one of claims 1-2, characterized in that: This preparation method specifically comprises the following steps: S1, complete the bottom coating; S2. Complete the top coating.

4. The method for preparing a central venous catheter coating formulation according to claim 3, characterized in that: The step S1 specifically includes the following steps: a1. Evenly mix 25-30 parts by weight of ethanol and 25-30 parts by weight of purified water; a2. Slowly add 50-60 parts by weight of primer and vibrate to mix evenly, then slowly add 1.5-2 parts by weight of crosslinking agent A and vibrate to mix for 5 minutes; a3. Coat the central venous catheter with the base coating by immersion; a4. Place the coated central venous catheter in a constant temperature drying oven to dry.

5. The method for preparing a central venous catheter coating formulation according to claim 3, characterized in that: The step S2 specifically includes the following steps: b1. Add 100-200 parts by weight of purified water to 1-3 parts by weight of crosslinking agent B and mix by vibration. Then slowly add 100-120 parts by weight of top coating agent and mix by vibration for 5 minutes. b2. Coat the central venous catheter with the top coating by immersion, and place the central venous catheter in a constant temperature drying oven to dry.

6. The method for preparing a central venous catheter coating formulation according to claim 4, characterized in that: In step a4, the constant temperature drying oven is set to 65° C. for drying for 30 minutes or 70° C. for drying for 15 minutes.

7. The method for preparing a central venous catheter coating formulation according to claim 5, characterized in that: In step b2, the constant temperature drying oven is set to 65° C. for drying for 120 minutes or 70° C. for drying for 90 minutes.

8. The method for preparing a central venous catheter coating formulation according to claim 4, characterized in that: The steps a1 and a2 are configured and used within one hour.

9. The method for preparing a central venous catheter coating formulation according to claim 5, characterized in that: The configuration in step b2 is completed and used within one hour.