Biological temperature control fermentation device for producing butanediol solution

Abstract

The biological temperature control fermentation device comprises a biological fermentation box and a fermentation area mechanism, the whole biological fermentation box is concave, the top of the biological fermentation box is open, cleaning nozzles are arranged at the bottom of the biological fermentation box, and gas side nozzles are arranged on the two sides of the bottom of the biological fermentation box; a fermentation area mechanism is located in the biological fermentation box; the fermentation area mechanism comprises a limiting side frame, a reaction screen plate, a lifting rod, embedded sliding plates and a filler strip plate, the reaction screen plate is embedded in the inner side of the limiting side frame, and the embedded sliding plates are arranged on the two sides of the reaction screen plate. In the prior art, in the fermentation process of an existing fermentation device, microorganisms need to breed and grow, the fermentation temperature is controlled through circulating water, however, the heat exchange speed is low, the heat exchange efficiency is influenced, the stirring and ventilation effects and the breeding environment are poor, and the growth speed of the microorganisms and the yield of metabolites can be directly influenced.

Description

Technical Field

[0001] The invention relates to the technical field of butanediol solution production, in particular to a biological temperature-controlled fermentation device for butanediol solution production. Background Art

[0002] Today's butanediol solution, the main component of which is butanediol, also known as 1,3-dihydroxybutane, is an organic substance. Butanediol solution is usually a colorless or light yellow oily liquid, hygroscopic, and can be used in cosmetics and personal care products, the medical field and the industrial field. Its excellent moisturizing properties and safety make it one of the preferred ingredients for many products. In the industrial field, butanediol can be used to make plasticizers, polyester resins, polyurethane resins, etc. It is an important raw material for the chemical, textile, papermaking, automotive and other industries. The production process of butanediol solution can vary according to different production methods. Among them, the biological method is one of the production methods. The fermentation liquid is obtained by fermentation, and the fermentation liquid is treated and separated to finally obtain a high-purity butanediol product.

[0003] During the fermentation process, existing fermentation devices require microorganisms to reproduce and grow, and the fermentation temperature is controlled by circulating water. However, the heat exchange rate is slow, which affects the heat exchange efficiency. In addition, the stirring and ventilation effects and the reproduction environment are poor, which directly affects the growth rate of microorganisms and the output of metabolites. Summary of the invention

[0004] The object of the present invention is to provide a biological temperature-controlled fermentation device for producing butanediol solution, so as to solve the problem that the existing fermentation device proposed in the above background technology requires microorganisms to reproduce and grow during the fermentation process, and the fermentation temperature is controlled by circulating water, but the heat exchange speed is slow, which affects the heat exchange efficiency, and the stirring and ventilation effects and the breeding environment are poor, which directly affects the growth rate of the microorganisms and the output of metabolites.

[0005] To achieve the above-mentioned object, the present invention provides the following technical scheme: a biological temperature-controlled fermentation device for producing a butanediol solution, comprising a biological fermentation box and a fermentation area mechanism, wherein the biological fermentation box is generally concave with an opening at the top, and cleaning nozzles are arranged and installed at the bottom of the biological fermentation box, and gas side nozzles are arranged on both sides of the bottom of the biological fermentation box, and a fermentation area mechanism is located inside the biological fermentation box;

[0006] The fermentation area mechanism comprises a limiting side frame, a reaction mesh plate, a lifting rod, an interlocking slide plate and a padding plate, wherein the reaction mesh plate is embedded in the inner side of the limiting side frame, the interlocking slide plates are arranged on both sides of the reaction mesh plate, and the lifting rods are arranged around the bottom of the interlocking slide plate, and the padding plates are arranged on both sides of the bottom of the reaction mesh plate;

[0007] The pad plate and the cleaning nozzle are symmetrically positioned up and down with each other;

[0008] A temperature regulating mechanism is arranged on the top of the biological fermentation tank, and the temperature regulating mechanism comprises a temperature control circulation plate, a direction-changing connecting pipe, a spiral hose and a side pump water tank. The two sides of the temperature control circulation plate are connected with direction-changing connecting pipes, and the connecting end of the direction-changing connecting pipe is provided with a spiral hose, and the side pump water tank is installed on the outside of the spiral hose. The temperature control circulation plate comprises a fixed circulation plate, a sliding circulation plate and a telescopic push rod. The sliding circulation plate is arranged on the top of the upper surface of the fixed circulation plate, and a telescopic push rod is horizontally arranged at the connection between the outer wall of the sliding circulation plate and the inner wall of the biological fermentation tank;

[0009] A limit plate is arranged on the top of the biological fermentation box, and limit grooves are arranged on the inner sides of both ends of the limit plate, the limit grooves are embedded between the fixed circulation plate and the sliding circulation plate, and a top cover plate is installed on the top of the limit plate;

[0010] An airflow rotating disk is embedded in the middle of the bottom of the biological fermentation box, and a driving motor is connected to the bottom shaft of the airflow rotating disk;

[0011] The gas inlet end of the gas side nozzle is connected to a gas supply device.

[0012] Furthermore, a discharge pipe is connected to one side of the bottom of the biological fermentation tank.

[0013] Furthermore, a horizontal transmission structure is formed between the sliding circulation plate and the telescopic push rod, and the sliding circulation plate is interlocked with the limiting plate through the limiting groove.

[0014] Furthermore, the biological fermentation box forms a wrapping structure through the limiting side frame and the reaction mesh plate, and the reaction mesh plate is horizontal and matches the inner diameter size of the biological fermentation box.

[0015] Furthermore, the position-limiting side frame forms an up-and-down sliding structure between the interlocking slide plate and the biological fermentation box, and an up-and-down transmission structure is formed between the lifting rod and the interlocking slide plate.

[0016] Furthermore, the reaction grid plate and the temperature control circulation plate are arranged horizontally and in parallel.

[0017] Furthermore, both sides of the fixed circulation plate and the sliding circulation plate are respectively connected with a change-of-direction connecting pipe, and the change-of-direction connecting pipe is connected to each other through a spiral hose and a side pump water tank.

[0018] Furthermore, the cleaning nozzles are symmetrically arranged in two groups, and each group of the cleaning nozzles is provided with eight groups, and each group of the cleaning nozzles and the pad plate are interlocked.

[0019] Furthermore, the spraying surface of the cleaning nozzle is arranged in a circular shape.

[0020] Furthermore, a temperature and humidity monitoring sensor is provided inside the biological fermentation box.

[0021] Compared with the prior art, the beneficial effects of the present invention are as follows: the biological temperature-controlled fermentation device for the production of butanediol solution adopts the mutual cooperation between multiple mechanisms, has strong functionality, uses the reaction mesh plate as the reproduction and production area of ​​microorganisms, and the filter holes of the reaction mesh plate ensure sufficient contact between the reaction solvent and the microorganisms on the basis of meeting the solvent penetration, and facilitates the microorganisms to form a stable biofilm on the surface of the filter hole, thereby improving the biological transformation efficiency; the lifting structure can flexibly adjust the contact depth between the microorganisms and the reaction solvent, so that the operator can accurately control the reproduction position of the microorganisms according to specific production needs, and further optimize the biological transformation process; cooperate with the heat circulation component on the top, by adjusting the vertical height of the microorganism, the distance between it and the heat circulation component can be accurately controlled. This design not only helps to achieve accurate heat transfer, but also can flexibly adjust the temperature according to the different temperature requirements of different stages of microbial growth.

[0022] 1. The present invention uses a temperature regulating mechanism as the main component of the heat circulation component, uses a temperature control circulation plate as a channel for the heat medium, and uses a fixed circulation plate and a sliding circulation plate as the main structure, so that the medium carrying heat can be synchronously transmitted from the reversing connecting pipe to transfer heat, thereby improving the temperature condition of the breeding space;

[0023] The laying structure of the temperature control circulation plate can block the opening of the biological fermentation box in a large area, making the heat transfer more concentrated and the heat conduction faster, thus making the heat control more precise;

[0024] The sliding circulation plate can slide on the upper surface of the fixed circulation plate, and the horizontal position of the sliding circulation plate can be adjusted to facilitate the smooth implementation of operations such as feeding and observation inside the biological fermentation box.

[0025] 2. In the present invention, the cleaning nozzle vertically arranged at the bottom of the biological fermentation box can spray the reaction mesh plate at the top under the action of the spray surface at the center of the circle during cleaning, so as to rinse and clean the surface of the reaction mesh plate, making the fermentation device more convenient to use;

[0026] The cleaning nozzle and the upper and lower positions of the pad plate are coordinated, so that when the pad plate descends with the reaction screen plate, the cleaning nozzle can be protected to avoid damage to the cleaning nozzle, thereby extending the service life of the cleaning nozzle;

[0027] The airflow rotating disk located in the middle of the cleaning nozzle can utilize the rotation of the airflow rotating disk to speed up the internal fluid rotation, ensure that the material is evenly distributed in the biological fermentation box, avoid the generation of vortexes and dead corners, and improve the stirring effect;

[0028] A gas side nozzle is further arranged on the inner side of the bottom of the biological fermentation box. It has a horizontal structure and can supply gas to the inside through the gas side nozzle. According to the growth needs of the microorganisms, an appropriate amount of oxygen or nitrogen and other gases are provided to the biological fermentation box to assist the microorganisms in fermentation and growth. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] Figure 1 A schematic diagram of the internal structure of a biological temperature-controlled fermentation device for producing a butanediol solution according to the present invention;

[0030] Figure 2 It is a schematic diagram of a partially enlarged structure of a fermentation area mechanism of a biological temperature-controlled fermentation device for producing a butanediol solution according to the present invention;

[0031] Figure 3 It is a schematic diagram of the internal structure of a biological temperature-controlled fermentation device for producing a butanediol solution according to the present invention from a side view;

[0032] Figure 4 A schematic diagram of a top view of the fermentation area mechanism of a biological temperature-controlled fermentation device for producing a butanediol solution according to the present invention;

[0033] Figure 5 A biological temperature-controlled fermentation device for producing a butanediol solution according to the present invention Figure 3 Schematic diagram of the local enlarged structure at point A in the middle.

[0034] In the figure: 1. biological fermentation box; 2. limit plate; 201. limit groove; 3. temperature adjustment mechanism; 301. temperature control circulation plate; 3011. fixed circulation plate; 3012. sliding circulation plate; 3013. telescopic push rod; 302. change-of-direction connecting pipe; 303. spiral hose; 304. side pump water tank; 4. fermentation area mechanism; 401. limit side frame; 402. reaction mesh plate; 403. lifting rod; 404. embedded slide plate; 405. pad plate; 5. cleaning nozzle; 6. gas supply device; 7. gas side nozzle; 8. air flow rotating disk; 9. top cover plate; 10. discharge pipe; 11. drive motor. DETAILED DESCRIPTION

[0035] In the description of the present invention, unless otherwise specified, "plurality" means two or more than two; the orientations or positional relationships indicated by the terms "upper", "lower", "left", "right", "inner", "outer", "front end", "rear end", "head", "tail", etc. are based on the orientations or positional relationships shown in the drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operate in a specific orientation, and therefore cannot be understood as limiting the present invention. In addition, the terms "first", "second", "third", etc. are only used for descriptive purposes and cannot be understood as indicating or implying relative importance.

[0036] In the description of the present invention, it should be noted that, unless otherwise clearly specified and limited, the terms "connected" and "connection" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0037] like Figure 1-5 As shown, the present invention provides a technical solution: a biological temperature-controlled fermentation device for producing a butanediol solution, a biological fermentation box 1 and a fermentation area mechanism 4, the biological fermentation box 1 is generally concave with an opening at the top, and a cleaning nozzle 5 is arranged and installed at the bottom of the biological fermentation box 1, and gas side nozzles 7 are arranged on both sides of the bottom of the biological fermentation box 1, and the fermentation area mechanism 4 is located inside the biological fermentation box 1;

[0038] The fermentation area mechanism 4 includes a limiting side frame 401, a reaction mesh plate 402, a lifting rod 403, an embedded slide plate 404 and a pad plate 405. The reaction mesh plate 402 is embedded inside the limiting side frame 401, and the embedded slide plates 404 are arranged on both sides of the reaction mesh plate 402. The lifting rod 403 is arranged around the bottom of the embedded slide plate 404, and the pad plates 405 are arranged on both sides of the bottom of the reaction mesh plate 402;

[0039] The pad plate 405 and the cleaning nozzle 5 are symmetrically matched with each other in the upper and lower positions;

[0040] A temperature regulating mechanism 3 is arranged on the top of the biological fermentation tank 1, and the temperature regulating mechanism 3 includes a temperature control circulation plate 301, a direction-changing connecting pipe 302, a spiral hose 303 and a side pump water tank 304. The two sides of the temperature control circulation plate 301 are connected with the direction-changing connecting pipe 302, and the connecting end of the direction-changing connecting pipe 302 is provided with a spiral hose 303, and the outer side of the spiral hose 303 is installed with the side pump water tank 304. The temperature control circulation plate 301 includes a fixed circulation plate 3011, a sliding circulation plate 3012 and a telescopic push rod 3013. The sliding circulation plate 3012 is arranged on the top of the upper surface of the fixed circulation plate 3011, and the telescopic push rod 3013 is horizontally arranged at the connection between the outer wall of the sliding circulation plate 3012 and the inner wall of the biological fermentation tank 1;

[0041] A limit plate 2 is arranged on the top of the biological fermentation box 1, and limit grooves 201 are provided on the inner sides of both ends of the limit plate 2. The limit grooves 201 are embedded between the fixed circulation plate 3011 and the sliding circulation plate 3012. A top cover plate 9 is installed on the top of the limit plate 2.

[0042] An airflow rotating disk 8 is embedded in the middle of the bottom of the biological fermentation box 1, and a driving motor 11 is connected to the bottom shaft of the airflow rotating disk 8;

[0043] The air inlet end of the gas side nozzle 7 is connected to the gas supply device 6; the bottom side of the biological fermentation box 1 is connected to the discharge pipe 10; the sliding circulation plate 3012 and the telescopic push rod 3013 form a horizontal transmission structure, and the sliding circulation plate 3012 is interlocked with the limiting plate 2 through the limiting groove 201; the biological fermentation box 1 forms a wrapping structure through the limiting side frame 401 and the reaction mesh plate 402, and the reaction mesh plate 402 is horizontal and matches the inner diameter size of the biological fermentation box 1; the limiting side frame 401 forms an up and down sliding structure through the interlocking slide plate 404 and the biological fermentation box 1 The movable structure is provided, and the lifting rod 403 and the interlocking slide plate 404 form an up and down transmission structure; the reaction mesh plate 402 and the temperature control circulation plate 301 are arranged horizontally in parallel; the fixed circulation plate 3011 and the sliding circulation plate 3012 are respectively connected with the change-direction connecting pipe 302 on both sides, and the change-direction connecting pipe 302 is connected with the side pump water tank 304 through the spiral hose 303; the cleaning nozzles 5 are symmetrically arranged in two groups, and each group of cleaning nozzles 5 is arranged in eight groups, and each group of cleaning nozzles 5 and the pad plate 405 are interlocked with each other; the spraying surface of the cleaning nozzle 5 is arranged in a circular shape.

[0044] The system adopts the cooperation between multiple mechanisms, and has strong functionality. The reaction mesh plate 402 is used as the reproduction and production area of ​​microorganisms. The filter holes of the reaction mesh plate 402 ensure sufficient contact between the reaction solvent and the microorganisms on the basis of meeting the solvent penetration, and facilitate the microorganisms to form a stable biofilm on the surface of the filter holes, thereby improving the biotransformation efficiency; the lifting structure can flexibly adjust the contact depth between the microorganisms and the reaction solvent, so that the operator can accurately control the reproduction position of the microorganisms according to specific production needs, and further optimize the biotransformation process; in conjunction with the heat circulation component on the top, by adjusting the vertical height of the microorganisms, the distance between them and the heat circulation component can be accurately controlled. This design not only helps to achieve accurate heat transfer, but also can flexibly adjust the temperature according to the different temperature requirements of the different stages of microbial growth.

[0045] The temperature regulating mechanism 3 is used as the main component of the heat circulation component, and the temperature control circulation plate 301 is used as the channel of the heat medium. The fixed circulation plate 3011 and the sliding circulation plate 3012 are used as the main structure, so that the medium carrying heat can be synchronously transmitted from the reversing connecting pipe 302 to transfer heat, thereby improving the temperature condition of the breeding space;

[0046] The laying structure of the temperature control circulation plate 301 can block the opening of the biological fermentation box 1 in a large range, so that the heat transfer is more concentrated and the heat conduction is faster, thereby making the heat control more precise;

[0047] The sliding circulation plate 3012 can slide on the upper surface of the fixed circulation plate 3011 , and the horizontal position of the sliding circulation plate 3012 can be adjusted to facilitate the smooth implementation of operations such as feeding and observation inside the biological fermentation box 1 .

[0048] The cleaning nozzle 5 vertically arranged at the bottom of the biological fermentation box 1 can spray the top reaction mesh plate 402 under the action of the spray surface at the center of the circle during cleaning, so as to rinse and clean the surface of the reaction mesh plate 402, making the fermentation device more convenient to use;

[0049] The cleaning nozzle 5 cooperates with the upper and lower positions of the pad plate 405, so that when the pad plate 405 descends with the reaction mesh plate 402, the cleaning nozzle 5 can be protected to avoid damage to the cleaning nozzle 5, thereby extending the service life of the cleaning nozzle 5;

[0050] The airflow rotating disk 8 located at the middle side of the cleaning nozzle 5 can utilize the rotation of the airflow rotating disk 8 to accelerate the internal fluid rotation, ensure that the material is evenly distributed in the biological fermentation box 1, avoid the generation of vortexes and dead corners, and improve the stirring effect;

[0051] A gas side nozzle 7 is further arranged on the inner side of the bottom of the biological fermentation box 1, which is in a horizontal structure, and can supply gas to the inside through the gas side nozzle 7. According to the growth requirements of the microorganisms, an appropriate amount of oxygen or nitrogen and other gases are provided to the biological fermentation box 1 to assist the microorganisms in fermentation and growth;

[0052] The reaction screen 402 adopts a lifting structure design, which can flexibly adjust the contact depth between the microorganisms and the reaction solvent. This feature allows operators to accurately control the reproduction position of microorganisms according to specific production needs and further optimize the biotransformation process. For example, when the microbial density needs to be increased, the position of the reaction screen can be lowered to increase the contact area between the microorganisms and the solvent; when the growth rate of the microorganisms needs to be controlled, the position of the reaction screen can be raised accordingly.

[0053] In addition, the top of the reaction grid plate 402 is equipped with a top heat circulation component, namely, the temperature regulating mechanism 3. By adjusting the vertical height of the microorganism, the distance between it and the temperature regulating mechanism 3 can be accurately controlled. This design not only helps to achieve accurate heat transfer, but also can flexibly adjust the temperature according to the different temperature requirements of the different stages of microbial growth. For example, during the vigorous growth period of microorganisms, the temperature can be increased by reducing the distance to promote the rapid reproduction of microorganisms; and after the microorganisms enter the stable growth period, the temperature can be reduced by increasing the distance to prevent the microorganisms from overheating and death;

[0054] The composition and function of the temperature control mechanism 3: The temperature control mechanism 3 is the core of the heat circulation component, which is mainly composed of the temperature control circulation plate 301. The temperature control circulation plate 301 serves as a channel for the heat medium and undertakes the important task of heat transfer. This design enables the heat medium to circulate in the system, thereby achieving uniform distribution and precise control of heat.

[0055] Structural features of the temperature control circulation plate 301: The temperature control circulation plate 301 adopts a laying structure, which consists of a fixed circulation plate 3011 and a sliding circulation plate 3012. This structural design not only enhances the stability of the system, but also improves the efficiency of heat transfer. The fixed circulation plate 3011, as the base part, provides stable support for the sliding circulation plate 3012; and the sliding circulation plate 3012 can slide on the upper surface of the fixed circulation plate 3011, thereby further adjusting the heat transfer.

[0056] Heat transfer and temperature improvement: The heat-carrying medium is synchronously transmitted through the reversing connecting pipe 302, and this process ensures that the heat can be evenly distributed in the system. By adjusting the flow and temperature of the heat medium on the temperature-controlled circulation plate 301, the temperature condition inside the biological fermentation box 1 can be significantly improved, providing suitable environmental conditions for the growth and reproduction of microorganisms.

[0057] The blocking effect of the temperature control circulation plate 301; the laying structure of the temperature control circulation plate 301 can also block the opening of the biological fermentation box 1 in a large range. This design makes the heat transfer more concentrated and the heat conduction faster. By reducing the loss and waste of heat, the system can achieve precise regulation of heat control, thereby meeting the different temperature requirements during the growth and reproduction of microorganisms.

[0058] The structure of the sliding circulation plate 3012: The sliding function of the sliding circulation plate 3012 provides great convenience for the internal operation of the biological fermentation box 1. By adjusting the horizontal position of the sliding circulation plate 3012, operations such as feeding and observation can be conveniently performed without interrupting the heat circulation and temperature control process, thereby ensuring the continuity and stability of the biological fermentation process.

[0059] It is to be understood that the above embodiments are merely exemplary embodiments used to illustrate the principles of the present invention, but the present invention is not limited thereto. For those of ordinary skill in the art, various modifications and improvements can be made without departing from the spirit and essence of the present invention, and these modifications and improvements are also considered to be within the scope of protection of the present invention.

Claims

1. A biological temperature-controlled fermentation device for producing butanediol solution, characterized in that: The invention comprises a biological fermentation box (1) and a fermentation area mechanism (4); the biological fermentation box (1) is generally concave in shape with an opening at the top, a cleaning nozzle (5) is arranged at the bottom of the biological fermentation box (1), and gas side nozzles (7) are arranged at both sides of the bottom of the biological fermentation box (1); and the fermentation area mechanism (4) is located inside the biological fermentation box (1); The fermentation area mechanism (4) comprises a limiting side frame (401), a reaction mesh plate (402), a lifting rod (403), an interlocking slide plate (404) and a padding plate (405); the reaction mesh plate (402) is embedded in the inner side of the limiting side frame (401); the interlocking slide plates (404) are arranged on both sides of the reaction mesh plate (402); the lifting rod (403) is arranged around the bottom of the interlocking slide plate (404); and the padding plates (405) are arranged on both sides of the bottom of the reaction mesh plate (402); The pad plate (405) and the cleaning nozzle (5) are symmetrically matched in upper and lower positions; A temperature regulating mechanism (3) is arranged on the top of the biological fermentation box (1), and the temperature regulating mechanism (3) comprises a temperature control circulation plate (301), a direction-changing connecting pipe (302), a spiral hose (303) and a side pump water tank (304). The two sides of the temperature control circulation plate (301) are connected with the direction-changing connecting pipe (302), and the connecting end of the direction-changing connecting pipe (302) is provided with a spiral hose (303), and the outer side of the spiral hose (303) is installed with the side pump water tank (304). The temperature control circulation plate (301) comprises a fixed circulation plate (3011), a sliding circulation plate (3012) and a telescopic push rod (3013). The sliding circulation plate (3012) is arranged on the top of the upper surface of the fixed circulation plate (3011), and the telescopic push rod (3013) is horizontally arranged at the connection between the outer wall of the sliding circulation plate (3012) and the inner wall of the biological fermentation box (1); A limiting plate (2) is arranged on the top of the biological fermentation box (1), and limiting grooves (201) are provided on the inner sides of both ends of the limiting plate (2), the limiting grooves (201) are embedded with the fixed circulation plate (3011) and the sliding circulation plate (3012), and a top cover plate (9) is installed on the top of the limiting plate (2); An airflow rotating disk (8) is embedded in the middle of the bottom of the biological fermentation box (1), and a driving motor (11) is connected to the bottom shaft of the airflow rotating disk (8); The gas inlet end of the gas side nozzle (7) is connected to a gas supply device (6).

2. The biological temperature-controlled fermentation device for producing a butanediol solution according to claim 1, characterized in that: A discharge pipe (10) is connected to one side of the bottom of the biological fermentation box (1).

3. The biological temperature-controlled fermentation device for producing a butanediol solution according to claim 1, characterized in that: A horizontal transmission structure is formed between the sliding circulation plate (3012) and the telescopic push rod (3013), and the sliding circulation plate (3012) is interlocked with the limiting plate (2) via the limiting groove (201).

4. The biological temperature-controlled fermentation device for producing a butanediol solution according to claim 1, characterized in that: The biological fermentation box (1) forms a wrapping structure through the limiting side frame (401) and the reaction mesh plate (402), and the reaction mesh plate (402) is horizontal and matches the inner diameter size of the biological fermentation box (1).

5. The biological temperature-controlled fermentation device for producing a butanediol solution according to claim 1, characterized in that: The position-limiting side frame (401) forms an up-and-down sliding structure between the interlocking slide plate (404) and the biological fermentation box (1), and an up-and-down transmission structure is formed between the lifting rod (403) and the interlocking slide plate (404).

6. The biological temperature-controlled fermentation device for producing a butanediol solution according to claim 1, characterized in that: The reaction mesh plate (402) and the temperature control circulation plate (301) are arranged horizontally and in parallel.

7. The biological temperature-controlled fermentation device for producing a butanediol solution according to claim 1, characterized in that: The two sides of the fixed circulation plate (3011) and the sliding circulation plate (3012) are respectively connected with a change-of-direction connecting pipe (302), and the change-of-direction connecting pipe (302) is connected to the side pump water tank (304) through a spiral hose (303).

8. The biological temperature-controlled fermentation device for producing a butanediol solution according to claim 1, characterized in that: The cleaning nozzles (5) are symmetrically arranged in two groups, and each group of the cleaning nozzles (5) is provided with eight groups, and each group of the cleaning nozzles (5) and the pad strip plate (405) are interlocked.

9. The biological temperature-controlled fermentation device for producing butanediol solution according to claim 1, characterized in that: The spraying surface of the cleaning nozzle (5) is arranged in a circular shape.

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