Filtering device for producing pharmaceutical-grade guanidine hydrochloride

Abstract

The utility model relates to the technical field of pharmaceutical-grade guanidine hydrochloride production, and particularly discloses a filtering device for pharmaceutical-grade guanidine hydrochloride production, which comprises an outer cylinder, a filtering cylinder is mounted in the outer cylinder, and a fixing frame is mounted on the outer wall of the outer cylinder. Two air cylinders with the output ends fixedly connected with the upper end face of the filter cartridge are installed on the upper end face of the fixing frame, a motor is installed on the upper end face of the filter cartridge, the output end of the motor penetrates through and extends into the filter cartridge and is fixedly connected with a stirring plate, and a filter cavity is formed in the lower end face of the outer barrel, so that the stirring plate stirs materials; according to the guanidine hydrochloride filtering device, a guanidine hydrochloride solution can flow into the outer cylinder through meshes of the filtering cylinder, and part of impurities stay in the filtering cylinder, so that the filtering efficiency is improved, and the solution in the outer cylinder sequentially passes through the first filtering plate and the second filtering plate, so that large and small impurities in the solution can be filtered; furthermore, the solution impurity filtering effect and quality can be improved.

Description

Technical Field

[0001] The utility model relates to the technical field of pharmaceutical-grade guanidine hydrochloride production, in particular to a filtering device for pharmaceutical-grade guanidine hydrochloride production. Background Art

[0002] Guanidine hydrochloride is an organic substance with CAS number 50-01-1 and molecular formula CH6ClN3. Ordinary guanidine hydrochloride products are commonly used organic synthesis intermediates for medicines, pesticides, dyes, etc. It is an important raw material for the manufacture of sulfa drugs such as sulfadiazine, sulfamethazine, sulfadimethoxine and folic acid, and can also be used as an antistatic agent for synthetic fibers. With the effective application of guanidine hydrochloride products in medicines, pesticides, dyes and other products, higher requirements are placed on the quality of guanidine hydrochloride products.

[0003] The production process of pharmaceutical-grade guanidine hydrochloride products is to subject ordinary guanidine hydrochloride raw materials to low-temperature dissolution, filtration and impurity removal, high-temperature decomposition and gasification to impurity removal, acidification and calcium neutralization, concentration and solubility reduction to impurity removal and other liquid purification steps, and then cool, crystallize and dry to obtain pharmaceutical-grade guanidine hydrochloride products.

[0004] At present, during the filtration process of pharmaceutical-grade guanidine hydrochloride production, the impurities after the reaction cannot be filtered in time while the material is dissolving, which reduces the filtration efficiency. At the same time, the solution filtration is relatively simple, and the filtration of large and small impurities inside is not comprehensive. Therefore, it is necessary to propose a filtration device for pharmaceutical-grade guanidine hydrochloride production to solve the above-mentioned problems. Utility Model Content

[0005] The utility model aims to provide a filtering device for producing pharmaceutical-grade guanidine hydrochloride, which has the characteristics of improving solution filtering efficiency and secondly improving the effect and quality of filtering solution impurities.

[0006] To achieve the above-mentioned purpose, the utility model provides the following technical solutions: a filtering device for producing pharmaceutical-grade guanidine hydrochloride, comprising an outer cylinder, a filter cylinder is installed inside the outer cylinder, a fixing frame is installed on the outer wall of the outer cylinder, a cylinder with two output ends fixedly connected to the upper end surface of the filter cylinder is installed on the upper end surface of the fixing frame, a motor is installed on the upper end surface of the filter cylinder, the output end of the motor penetrates and extends into the filter cylinder and is fixedly connected to a stirring plate;

[0007] A filter cavity is installed on the lower end surface of the outer cylinder, and two groups of support plates are installed inside the filter cavity. The upper end surfaces of the two groups of support plates are respectively placed with a first filter plate and a second filter plate located below the first filter plate, and the lower end surfaces of the first filter plate and the second filter plate are both installed with liquid guide grooves.

[0008] In order to filter the guanidine hydrochloride solution multiple times, as a preferred filtering device for producing pharmaceutical-grade guanidine hydrochloride of the utility model, the mesh diameters of the filter cartridge, the first filter plate and the second filter plate become smaller in sequence.

[0009] In order to enable the filter cartridge to be stably moved out of the outer cylinder, as a preferred filtering device for producing pharmaceutical-grade guanidine hydrochloride of the utility model, a slide groove is installed on the inner wall of the outer cylinder, and connecting rods slidably connected to the slide groove are fixedly connected on both sides of the filter cartridge.

[0010] In order to accelerate the dissolution of the material, as a preferred filtering device for producing pharmaceutical-grade guanidine hydrochloride of the utility model, the inner wall of the filter cylinder is installed with a plurality of heating tubes distributed in a ring shape.

[0011] In order to allow the solution in the outer cylinder to smoothly enter the filter cavity for filtration, as a preferred filtering device for the production of pharmaceutical-grade guanidine hydrochloride in the utility model, the lower end surface of the filter cylinder is connected to a discharge port, the lower end surface of the outer cylinder is connected to a liquid outlet pipe connected to the filter cavity, and the lower end surface of the filter cavity is connected to a liquid discharge pipe.

[0012] In order to control the normal operation of the motor, the cylinder and the heating tube, as a preferred filtering device for producing pharmaceutical-grade guanidine hydrochloride of the utility model, a controller is installed on the right side of the outer cylinder, and the motor, the cylinder and the heating tube are all electrically connected to the controller.

[0013] Compared with the prior art, the beneficial effects of the utility model are as follows:

[0014] The utility model firstly enables the stirring plate to stir the material to accelerate the dissolution of the material, and at the same time enables the guanidine hydrochloride solution to flow into the outer cylinder through the mesh of the filter cylinder, and some impurities remain in the filter cylinder, thereby improving the filtering efficiency; secondly, the solution in the outer cylinder passes through the first filter plate and the second filter plate in sequence to filter the large and small impurities in the solution, thereby improving the effect and quality of filtering the solution impurities. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 It is the overall structure diagram of the utility model;

[0016] Figure 2 This is a three-dimensional structural diagram of the filter chamber of the utility model;

[0017] Figure 3 This is a three-dimensional structural diagram of the filter cartridge of the present utility model.

[0018] In the figure: 1. outer cylinder; 101. slideway; 102. fixing frame; 103. cylinder; 2. filter cylinder; 201. heating tube; 202. motor; 203. stirring plate; 204. connecting rod; 205. impurity discharge port; 3. filter chamber; 301. support plate; 302. first filter plate; 303. second filter plate; 304. liquid guide groove; 305. liquid discharge pipe; 4. controller. DETAILED DESCRIPTION

[0019] See also Figures 1 to 3 A filtering device for producing pharmaceutical-grade guanidine hydrochloride, comprising an outer cylinder 1, a filter cylinder 2 is installed inside the outer cylinder 1, a fixing frame 102 is installed on the outer wall of the outer cylinder 1, a cylinder 103 with two output ends fixedly connected to the upper end surface of the filter cylinder 2 is installed on the upper end surface of the fixing frame 102, a motor 202 is installed on the upper end surface of the filter cylinder 2, the output end of the motor 202 penetrates and extends into the filter cylinder 2 and is fixedly connected to a stirring plate 203;

[0020] A filter chamber 3 is installed on the lower end surface of the outer cylinder 1, and two groups of support plates 301 are installed inside the filter chamber 3. The upper end surfaces of the two groups of support plates 301 are respectively placed with a first filter plate 302 and a second filter plate 303 located below the first filter plate 302, and the lower end surfaces of the first filter plate 302 and the second filter plate 303 are both installed with a liquid guide groove 304.

[0021] In this embodiment: materials and water are placed in the filter cartridge 2, and the motor 202 is started, so that the motor 202 drives the stirring plate 203 to rotate, prompting the stirring plate 203 to stir the materials and accelerate the dissolution of the materials. After the dissolution reaction, the guanidine hydrochloride solution can flow into the outer cylinder 1 through the mesh of the filter cartridge 2, and some impurities remain in the filter cartridge 2, thereby improving the filtration efficiency. Then, the cylinder 103 is started, so that the cylinder 103 pulls the filter cartridge 2 upward until the filter cartridge 2 moves out of the outer cylinder 1, and then the impurities in the filter cartridge 2 can be discharged. Then, the solution in the outer cylinder 1 enters the filter cavity 3, and passes through the first filter plate 302 and the second filter plate 303 in sequence, and then the large and small impurities in the solution can be filtered through the first filter plate 302 and the second filter plate 303, thereby improving the effect and quality of filtering the solution impurities.

[0022] As a technical optimization solution of the present invention, the mesh diameters of the filter cartridge 2, the first filter plate 302 and the second filter plate 303 become smaller in sequence.

[0023] In this embodiment, the mesh diameters of the filter cartridge 2, the first filter plate 302 and the second filter plate 303 are successively reduced, so as to facilitate multiple filtration of the guanidine hydrochloride solution, thereby reducing impurities in the solution.

[0024] As a technical optimization solution of the present invention, a slide groove 101 is installed on the inner wall of the outer cylinder 1 , and connecting rods 204 slidably connected to the slide groove 101 are fixedly connected to the left and right sides of the filter cylinder 2 .

[0025] In this embodiment, the connecting rod 204 and the slide groove 101 cooperate with each other to support the filter cartridge 2 and enable the filter cartridge 2 to be stably moved out of the outer cartridge 1 .

[0026] As a technical optimization solution of the present invention, a plurality of heating tubes 201 distributed in a ring shape are installed on the inner wall of the filter cartridge 2 .

[0027] In this embodiment, the material in the filter cartridge 2 can be heated by the heating tube 201, thereby accelerating the dissolution of the material.

[0028] As a technical optimization solution of the utility model, the lower end face of the filter cylinder 2 is connected to a discharge port 205, the lower end face of the outer cylinder 1 is connected to a liquid outlet pipe connected to the filter chamber 3, and the lower end face of the filter chamber 3 is connected to a discharge pipe 305.

[0029] In this embodiment, impurities in the filter cartridge 2 can be discharged through the impurity discharge port 205, the solution in the outer cartridge 1 can smoothly enter the filter chamber 3 for filtration through the liquid outlet pipe, and the filtered solution can be smoothly discharged and collected through the liquid discharge pipe 305.

[0030] As a technical optimization solution of the present invention, a controller 4 is installed on the right side of the outer tube 1 , and the motor 202 , the cylinder 103 and the heating tube 201 are all electrically connected to the controller 4 .

[0031] In this embodiment, the controller 4 can control the motor 202, the cylinder 103 and the heating tube 201 to work normally.

[0032] Working principle: firstly, put the material and water into the filter cartridge 2, and start the motor 202, so that the motor 202 drives the stirring plate 203 to rotate, prompting the stirring plate 203 to stir the material and accelerate the dissolution of the material. After the dissolution reaction, the guanidine hydrochloride solution can flow into the outer cylinder 1 through the mesh of the filter cartridge 2, and some impurities remain in the filter cartridge 2, thereby improving the filtration efficiency. Then, start the cylinder 103, so that the cylinder 103 pulls the filter cartridge 2 upward until the filter cartridge 2 moves out of the outer cylinder 1, and then the impurities in the filter cartridge 2 can be discharged. Secondly, the solution in the outer cylinder 1 enters the filter cavity 3, and passes through the first filter plate 302 and the second filter plate 303 in turn, and then the large and small impurities in the solution can be filtered through the first filter plate 302 and the second filter plate 303, thereby improving the effect and quality of filtering the solution impurities.

[0033] The above are only preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A filtering device for producing pharmaceutical-grade guanidine hydrochloride, comprising an outer cylinder (1), Features: A filter cartridge (2) is installed inside the outer cartridge (1), a fixing frame (102) is installed on the outer wall of the outer cartridge (1), a cylinder (103) having two output ends fixedly connected to the upper end surface of the filter cartridge (2) is installed on the upper end surface of the fixing frame (102), a motor (202) is installed on the upper end surface of the filter cartridge (2), the output end of the motor (202) penetrates and extends into the filter cartridge (2) and is fixedly connected to a stirring plate (203); A filter chamber (3) is installed on the lower end surface of the outer cylinder (1), and two groups of support plates (301) are installed inside the filter chamber (3). A first filter plate (302) and a second filter plate (303) located below the first filter plate (302) are placed on the upper end surfaces of the two groups of support plates (301), respectively, and a liquid guide groove (304) is installed on the lower end surfaces of the first filter plate (302) and the second filter plate (303).

2. A filtering device for producing pharmaceutical-grade guanidine hydrochloride according to claim 1, Features: The mesh diameters of the filter cartridge (2), the first filter plate (302), and the second filter plate (303) decrease in sequence.

3. A filtering device for producing pharmaceutical-grade guanidine hydrochloride according to claim 1, Features: A slide groove (101) is installed on the inner wall of the outer cylinder (1), and connecting rods (204) slidably connected to the slide groove (101) are fixedly connected to the left and right sides of the filter cylinder (2).

4. A filtering device for producing pharmaceutical-grade guanidine hydrochloride according to claim 1, Features: The inner wall of the filter cartridge (2) is provided with a plurality of heating tubes (201) distributed in a ring shape.

5. A filtering device for producing pharmaceutical-grade guanidine hydrochloride according to claim 1, Features: The lower end surface of the filter cylinder (2) is connected to a discharge port (205), the lower end surface of the outer cylinder (1) is connected to a liquid outlet pipe connected to the filter chamber (3), and the lower end surface of the filter chamber (3) is connected to a liquid discharge pipe (305).

6. A filtering device for producing pharmaceutical-grade guanidine hydrochloride according to claim 1, Features: A controller (4) is installed on the right side of the outer cylinder (1), and the motor (202), the cylinder (103) and the heating tube (201) are all electrically connected to the controller (4).

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