Reaction equipment

Abstract

The utility model provides reaction equipment which at least comprises a reaction cavity, the reaction cavity is provided with a first port and a second port, and the reaction cavity is used for accommodating reaction liquid and enabling the reaction liquid to flow back and forth in the reaction cavity under the action of external force for reaction; according to the utility model, reciprocating flow is carried out in the reaction cavity, the whole movement of the reaction liquid is more uniform during reciprocating flow, the movement consistency is stronger, and the reaction and mixing are more facilitated; the reciprocating flow speed is accurate and adjustable, the rhythm is accurate and adjustable, and the response can be accurately and quickly realized.

Description

Technical Field

[0001] The utility model relates to the field of biochemistry, in particular to a reaction device. Background Art

[0002] Whether it is a chemical or biological reaction, such as nucleic acid amplification reaction, enzyme reaction, transcription reaction and other reactions, the reaction liquid needs to be mixed during the reaction process to complete the reaction more efficiently. At present, the mixing method in the reaction process is generally shaking, oscillating or oscillating, which is to move the reaction container containing the reaction liquid for reaction to achieve mixing. In this way, the overall movement of the reaction liquid is poor, and many mechanisms are required and the operation is complicated, which increases the cost. In addition, the equipment will also suffer from various problems such as wear and damage after a long time of use.

[0003] Therefore, it is necessary to solve the above defects of using shaking, rocking, oscillation and the like in the reaction. Utility Model Content

[0004] The utility model provides a reaction device to overcome the defects of the above-mentioned reaction methods such as shaking, oscillating and oscillating.

[0005] A reaction device, the reaction device at least comprising:

[0006] A reaction chamber is provided with a first port and a second port, and the reaction chamber is used to contain a reaction liquid. The reaction liquid can flow back and forth inside the reaction chamber under the action of an external force to react.

[0007] In one embodiment, the reaction chamber has at least one curved section. Preferably, the reaction chamber has a plurality of continuous curved sections. In another embodiment, the reaction chamber is a coil.

[0008] In one embodiment, the reaction device further comprises:

[0009] A constant temperature component is provided, wherein the constant temperature component can keep the reaction liquid at a constant temperature during the reciprocating flow process.

[0010] In one embodiment, the thermostatic component comprises:

[0011] A constant temperature container, used to contain a heat exchange medium, wherein the reaction chamber is located in the constant temperature container and can perform heat exchange with the heat exchange medium; preferably, the constant temperature container has a heat insulation layer;

[0012] A thermostat, which heats and / or cools the heat exchange medium to keep the constant temperature container at a constant temperature;

[0013] Preferably, the heat exchange medium is a fluid, more preferably, the fluid is water;

[0014] Another preferred embodiment is that the thermostat is located at the bottom of the constant temperature container.

[0015] In one embodiment, the reaction device further comprises:

[0016] An inlet and outlet assembly, used to allow external liquid to enter the reaction chamber and allow liquid inside the reaction chamber to be discharged from the reaction chamber;

[0017] Preferably, the inlet and outlet assembly comprises a bidirectional pump;

[0018] Another preferred embodiment is that the inlet and outlet assembly comprises an inlet unit and an outlet unit;

[0019] The entry unit is used to allow external liquid to enter the reaction chamber;

[0020] The discharge unit is used to discharge the liquid in the reaction chamber from the reaction chamber;

[0021] Furthermore, the inlet unit and the outlet unit are also used to provide external force to allow the reaction liquid to perform the reciprocating flow.

[0022] In one embodiment, the entry unit comprises:

[0023] A first pump assembly, wherein the first pump assembly has a first pump, the first pump is connected to the reaction chamber, and is used to allow liquid to enter the reaction chamber. Preferably, the first pump is a vacuum pump. Another preferred embodiment is that the first pump is connected to the reaction chamber through the first port. Preferably, the first port is located at the top of the reaction chamber.

[0024] In one embodiment, the discharge unit comprises:

[0025] A second pump assembly, wherein the second pump assembly comprises a second pump, wherein the second pump is connected to the reaction chamber and is used to discharge liquid from the interior of the reaction chamber. Preferably, the second pump is a positive pressure pump.

[0026] In one embodiment, the discharge unit further comprises:

[0027] Pressure regulators and gas filters;

[0028] The pressure regulator is used to adjust the compressed gas pressed into the second pump assembly from the outside to a corresponding gas pressure;

[0029] The air filter is used to filter the gas entering the reaction chamber.

[0030] In one embodiment, the inlet and outlet assembly further comprises:

[0031] A first three-way valve, wherein the first three-way valve is connected to the first pump, the second pump and the reaction chamber respectively, and is used to connect or close the first pump or the second pump to the reaction chamber. Preferably, the first three-way valve is arranged at the first port.

[0032] In one embodiment, the reaction device further comprises:

[0033] A solution bottle, the solution bottle is connected to the reaction chamber and is used to contain liquid entering the reaction chamber and / or liquid discharged from the reaction chamber. The solution bottle is connected to the reaction chamber through the second port. Preferably, the solution bottle and the second port are connected through a liquid pipeline. Preferably, the second port is located at the bottom of the reaction chamber, and the position where the liquid pipeline is connected to the solution bottle is located near the top of the reaction chamber.

[0034] In one embodiment, the reaction device further includes a heat exchange medium component, and the heat exchange medium component includes:

[0035] A heat exchange pipe, wherein a first end of the heat exchange pipe extends into the bottom of the constant temperature container, and a second end of the heat exchange pipe extends to the outside of the constant temperature container;

[0036] A third pump is connected to the second end of the heat exchange pipe and is used to circulate the heat exchange medium of the fluid to the interior of the constant temperature container through the heat exchange pipe, and / or to discharge the heat exchange medium of the fluid from the interior of the constant temperature container through the heat exchange pipe.

[0037] In one embodiment, the reaction device further comprises:

[0038] The liquid level sensor assembly is used to send a sensing signal to activate the third pump.

[0039] In one embodiment, the liquid level sensor assembly includes:

[0040] The emptying liquid level sensor is located at the bottom of the constant temperature container. When the emptying liquid level sensor sends a signal, the third pump stops discharging the heat exchange medium from the interior of the constant temperature container.

[0041] In one embodiment, the liquid level sensor assembly includes:

[0042] A maximum liquid level sensor is located at the top of the constant temperature container. When the maximum liquid level sensor sends a signal, the third pump stops inputting the heat exchange medium into the constant temperature container.

[0043] In one embodiment, the liquid level sensor assembly includes:

[0044] A standard liquid level sensor, the standard liquid level sensor is located below the maximum liquid level sensor and above the emptying liquid level sensor, wherein a vertical distance between the standard liquid level sensor and the emptying liquid level sensor is much greater than a distance between the standard liquid level sensor and the maximum liquid level sensor;

[0045] When the standard liquid level sensor sends a signal, the third pump starts to circulate the heat exchange medium into the constant temperature container through the heat exchange pipe.

[0046] In one embodiment, the reaction device further comprises:

[0047] First liquid sensor,

[0048] The first liquid sensor is used to sense liquid inflow and / or liquid discharge:

[0049] When the first liquid sensor sends a signal that there is liquid, the first pump component stops the action of allowing the liquid to enter or discharge the reaction chamber; or

[0050] The first liquid sensor is used to perform liquid sensing on the first displacement endpoint of the reaction liquid when the reaction liquid performs the reciprocating flow.

[0051] In one embodiment, the reaction device further comprises:

[0052] Second liquid sensor,

[0053] The second liquid sensor is used to sense liquid inflow and / or liquid discharge;

[0054] When the second liquid sensor sends a liquid-free signal, the second pump assembly stops the action of discharging the liquid from the reaction chamber; or

[0055] The second liquid sensor is used to perform liquid sensing on the second displacement endpoint of the reaction liquid when the reaction liquid performs the reciprocating flow.

[0056] In one embodiment, the reaction device further comprises:

[0057] A display screen, wherein the display screen is used for an operator to input operating instructions; and / or

[0058] A control component is used to control the operation of the reaction device.

[0059] In one embodiment, the reaction device further comprises:

[0060] A weighing device is used to weigh the weight of the solution bottle and control the amount of liquid entering the reaction chamber through a weight signal provided by the weighing device.

[0061] In one embodiment, the second port is disposed at the bottom of the reaction chamber, and the second port is provided with a second three-way valve, and the second three-way valve is also connected to the external discharge pipeline and the solution bottle;

[0062] Preferably, the solution bottle is arranged above the reaction chamber;

[0063] Preferably, the external discharge port on the external discharge pipeline is located at the lowest point of the reaction equipment.

[0064] A reaction method comprising:

[0065] Under the action of external force, the reaction liquid is made to flow back and forth in the reaction chamber for a predetermined time to complete the reaction.

[0066] In one embodiment, the reaction liquid maintains a constant temperature while flowing back and forth in the reaction chamber for a predetermined time.

[0067] In one embodiment, the reaction liquid is caused to reciprocate in the reaction chamber for a predetermined time under the action of an external force to complete the reaction, and the process also includes:

[0068] When the weight change in the solution bottle reaches a preset weighing condition, the introduction of the reaction solution is stopped.

[0069] In one embodiment, the reaction liquid is caused to reciprocate in the reaction chamber for a predetermined time under the action of an external force to complete the reaction, and then the process further includes:

[0070] When the weight of the solution bottle no longer changes and lasts for a preset time, the discharge of the reaction solution from the reaction chamber stops.

[0071] In one embodiment:

[0072] Performing the reciprocating flow within a predetermined displacement range for a predetermined time;

[0073] Preferably, based on the preset external force control condition, the reaction liquid is caused to reciprocate within the predetermined distance range inside the reaction chamber for a predetermined time to complete the reaction;

[0074] Preferably, the preset external force control condition includes a preset external force magnitude.

[0075] Beneficial Effects

[0076] The reaction chamber of the utility model is provided with a first port and a second port, and the reaction chamber is used to contain a reaction liquid, and the reaction liquid can flow back and forth inside the reaction chamber under the action of an external force to react; thereby, the following effects can be achieved:

[0077] 1. During the reaction process, there is no need to use complex equipment. It can be achieved by simply using external force to make the reaction liquid in the reaction chamber flow back and forth, which is simple to operate;

[0078] 2. During the reaction process, the reaction chamber is stationary, there is no contact with moving components, and there will be no wear and damage;

[0079] 3. During the reaction process, the reaction liquid reciprocates in the reaction chamber, which can make the overall movement of the reaction liquid more uniform, the movement consistency is stronger, and it is more conducive to the reaction;

[0080] 4. Compared with the existing shaking, swaying and oscillation methods, since the reciprocating flow is a whole back and forth movement, the overall flow speed and rhythm can be precisely adjusted, and the response can be achieved accurately and quickly;

[0081] 5. Combining the effects of the third and fourth points above, it can be seen that the above process is gentler and more beneficial for more fragile reactions;

[0082] 6. Based on the reciprocating flow of the utility model, the reaction chamber can be formed into a structure with at least one curved section and folded multiple times to reduce the occupied space;

[0083] 7. In addition, when using coils, heat exchange can be achieved faster and constant temperature can be maintained more easily, which is more beneficial for temperature-sensitive reactions. BRIEF DESCRIPTION OF THE DRAWINGS

[0084] In order to more clearly illustrate the technical solutions in the present invention or the prior art, a brief introduction will be given below to the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings described below are some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0085] Figure 1 It is a structural schematic diagram of the reaction equipment provided by the utility model. DETAILED DESCRIPTION

[0086] In order to make the purpose, technical solution and advantages of the utility model clearer, the technical solution of the utility model will be described clearly and completely in conjunction with the drawings in the utility model. Obviously, the described embodiments are part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0087] Figure 1 The schematic diagram of the structure of the reaction equipment provided by the utility model is as follows: Figure 1 As shown, the reaction equipment at least includes:

[0088] The reaction chamber 5 is provided with a first port and a second port. The reaction chamber is used to contain a reaction liquid. The reaction liquid can flow back and forth inside the reaction chamber under the action of an external force to react.

[0089] The reaction equipment can be used for various reactions, such as constant temperature nucleic acid amplification reaction, enzyme reaction, transcription reaction; in addition, the reaction equipment can also be used for mixing various solutions, etc.

[0090] Specifically, this embodiment is not directed to a specific reaction, and any mixing in the reaction that can be achieved by the above reaction equipment is within the protection scope of this embodiment.

[0091] The reaction equipment of this embodiment can be automatically controlled and intelligently controlled. Of course, this embodiment does not exclude manual operation, but it will reduce the working efficiency and speed of the reaction equipment.

[0092] Reciprocating flow is a control result of the working form of the reaction liquid in the reaction chamber. Specifically, the reaction liquid in the reaction chamber can flow from the first displacement end point to the second displacement end point as a whole through the action of external force, and then flow from the second displacement end point to the first displacement end point. The reaction liquid repeats this flow in the reaction chamber, which is the reciprocating flow of the utility model. The external force in this article refers to the power that can drive the liquid to flow, such as through a pump, gravity difference, etc.

[0093] The reciprocating flow in the reaction chamber can make the overall movement of the reaction liquid more uniform, the movement consistency is stronger, and it is more conducive to reaction and mixing; moreover, the speed and rhythm of the reciprocating flow are precisely adjustable, and the reaction can be achieved accurately and quickly.

[0094] When the liquid flows back and forth inside the reaction chamber to react, there is no need to use complex equipment, and only the above-mentioned reaction chamber is needed to achieve the reaction, which is simple to operate; in the above process, there is no contact of moving elements in the reaction chamber, and no wear or damage problems will occur; in the above process, the liquid flows back and forth in the reaction chamber, and the overall movement of the liquid is more uniform during the reciprocating flow, the movement consistency is stronger, and it is more conducive to reaction and mixing; the speed of the reciprocating flow can be precisely adjusted, and the rhythm can be precisely adjusted, so the reaction can be achieved accurately and quickly; for relatively fragile reactions and temperature-sensitive reactions, the above process can better promote the reaction and improve the reaction efficiency and rate.

[0095] In one embodiment, the reaction chamber has at least one curved section. Preferably, all reaction chambers have a plurality of continuous curved sections. By bending, the reaction chambers can be stacked to reduce the occupied space.

[0096] In another preferred embodiment, the reaction chamber is a coil, which can better achieve heat exchange, thereby ensuring the temperature requirement during the reaction process.

[0097] like Figure 1 As shown, the reaction chamber 5 is a coil, and the coil is laid in circles from bottom to top to form a spring-like stacked shape.

[0098] In one embodiment, the reaction device further comprises:

[0099] A constant temperature component is provided, wherein the constant temperature component can keep the reaction liquid at a constant temperature during the reciprocating flow process.

[0100] Some reaction processes need to be carried out at a certain temperature, such as nucleic acid isothermal amplification reaction. The isothermal component can control the temperature to ensure constant temperature during the reaction process.

[0101] In one embodiment, the thermostatic component comprises:

[0102] A constant temperature container 17, used to contain a heat exchange medium, wherein the reaction chamber 5 is located in the constant temperature container 17 and can perform heat exchange with the heat exchange medium; preferably, the constant temperature container has a heat insulation layer;

[0103] A thermostat 16, wherein the thermostat 16 heats and / or cools the heat exchange medium so as to keep the constant temperature container 17 at a constant temperature;

[0104] Preferably, the heat exchange medium is a fluid, more preferably, the fluid is water;

[0105] Another preferred embodiment is that the thermostat 16 is located at the bottom of the constant temperature container 17 .

[0106] The constant temperature container 17 can be a square container or other three-dimensional shapes. The volume of the constant temperature container should be large enough to accommodate the heat exchange medium and the reaction chamber. In order to quickly heat up and maintain the temperature of the reaction chamber constant after heating, the constant temperature container can be provided with an insulation layer, which can make the heat of the heat exchange medium in the constant temperature container dissipate slowly to the outside. When the thermostat 16 is heated, the speed of heating the heat exchange medium can be increased, so that the constant temperature container 17 can be quickly heated to a predetermined constant temperature, so that the reaction liquid inside the reaction chamber reaches the corresponding constant temperature. When the temperature of the constant temperature container is high and exceeds the required temperature, the thermostat 16 can cool the constant temperature container.

[0107] The heat exchange medium herein refers to a medium that can contact with the reaction chamber to exchange heat in the reaction chamber, and can be a fluid such as a liquid or a gas, or a fast heat conductor, etc., as long as the reaction liquid can be kept at a constant temperature during the reciprocating flow.

[0108] In one embodiment, the reaction device further comprises:

[0109] The inlet and outlet assembly is used to allow external liquid to enter the reaction chamber and to allow liquid inside the reaction chamber to be discharged from the reaction chamber.

[0110] Where there is no special indication in this document, "liquid" is at least a reaction liquid, and sometimes can also be, for example, a cleaning liquid. For example, the inlet and outlet assembly at least realizes the inlet and outlet of the reaction liquid; it can also be used for the inlet and outlet of the cleaning liquid for cleaning the reaction chamber at the same time, which will not be described in detail below;

[0111] Preferably, the inlet and outlet assembly comprises a bidirectional pump;

[0112] Another preferred embodiment is that the inlet and outlet assembly comprises an inlet unit and an outlet unit;

[0113] The entry unit is used to allow external liquid to enter the reaction chamber;

[0114] The discharge unit is used to discharge the solution in the reaction chamber from the reaction chamber;

[0115] Furthermore, the inlet unit and the outlet unit are also used to provide external force to allow the reaction liquid to perform the reciprocating flow.

[0116] Liquid needs to enter the reaction chamber and needs to be discharged from the reaction chamber after the reaction. This embodiment uses an inlet and outlet assembly to allow the liquid to enter and discharge the reaction chamber.

[0117] In one embodiment, the entry unit comprises:

[0118] The first pump assembly comprises a first pump 7, which is connected to the reaction chamber 5 and is used to allow liquid to enter the reaction chamber. Preferably, the first pump is a vacuum pump. Preferably, the first pump 7 is connected to the reaction chamber 5 through the first port. Preferably, the first port is located at the top of the reaction chamber. The first port is one of the ports of the reaction chamber, which is not shown in the figure.

[0119] The first pump 7 is connected to the first interface 8. When the first pump is working, the gas inside the reaction chamber can be discharged from the first interface 8, so that the liquid can be sucked into the reaction chamber.

[0120] In one embodiment, the discharge unit comprises:

[0121] A second pump assembly, wherein the second pump assembly comprises a second pump, wherein the second pump is connected to the reaction chamber and is used to discharge liquid from the interior of the reaction chamber. Preferably, the second pump is a positive pressure pump.

[0122] like Figure 1 As shown, a second pump (not shown) is connected to the second interface 9, and gas can be introduced from the second interface 9 to discharge the liquid in the reaction chamber from the reaction chamber. The gas pressure introduced by the second pump is large enough to discharge the liquid from the reaction chamber.

[0123] In one embodiment, the discharge unit further comprises:

[0124] A pressure regulator 10 and a gas filter 11;

[0125] The pressure regulator 10 is used to adjust the compressed gas pressed from the outside by the second pump assembly to a corresponding gas pressure;

[0126] The air filter is used to filter the gas entering the reaction chamber.

[0127] The pressure regulator can be an air compressor, etc., which can adjust the pressure of the gas entering the reaction chamber to fully meet the following conditions: the gas entering the reaction chamber can discharge the liquid from the reaction chamber. The air filter can filter the gas to ensure that the gas entering the reaction chamber does not affect the liquid.

[0128] The gas may first pass through the pressure regulator 10 and the gas filter 11 before entering the reaction chamber, or may first pass through the gas filter 11 and the pressure regulator 10 before entering the reaction chamber. Therefore, there is no order in which the pressure regulator 10 and the gas filter 11 are positioned.

[0129] In one embodiment, the inlet and outlet assembly further comprises:

[0130] The first three-way valve 6 is connected to the first pump 7, the second pump and the reaction chamber 5 respectively, and is used to connect or close the first pump component or the second pump component to the reaction chamber. Preferably, the first three-way valve is arranged at the first port.

[0131] In one embodiment, the reaction device further comprises:

[0132] A solution bottle 3, wherein the solution bottle 3 is connected to the reaction chamber 5 and is used to accommodate liquid entering the reaction chamber for reaction and / or accommodating liquid discharged from the reaction chamber. The solution bottle 3 is connected to the reaction chamber 5 through the second port. Preferably, the solution bottle and the second port are connected through a liquid pipeline. Preferably, the second port is located at the bottom of the reaction chamber, and the position where the liquid pipeline is connected to the solution bottle is located near the top of the reaction chamber.

[0133] In one embodiment, the first three-way valve 6 is controlled to connect the first pump 7 to the reaction chamber 5 , or to connect the second pump to the reaction chamber.

[0134] In one embodiment, the reaction device further comprises a heat exchange medium component, and the heat exchange medium component comprises:

[0135] A heat exchange pipe, wherein a first end of the heat exchange pipe extends into the bottom of the constant temperature container, and a second end of the heat exchange pipe extends to the outside of the constant temperature container;

[0136] The third pump 14 is connected to the second end of the heat exchange pipe and is used to circulate the heat exchange medium, which is a fluid, into the interior of the constant temperature container through the heat exchange pipe, and / or to discharge the heat exchange medium, which is a fluid, from the interior of the constant temperature container through the heat exchange pipe.

[0137] like Figure 1 As shown, the second end of the heat exchange pipe has a third interface 15. When the third pump 14 is working, the heat exchange medium (such as water) can be drawn from the outside through the third interface 15 and circulated to the inside of the constant temperature container through the heat exchange pipe; the heat exchange medium can also be discharged from the inside of the constant temperature container through the heat exchange pipe and discharged to the outside through the third interface 15.

[0138] In one embodiment, the reaction device further comprises:

[0139] The liquid level sensor assembly is used to send a sensing signal to activate the third pump.

[0140] Specifically, the liquid level sensor assembly includes:

[0141] The emptying liquid level sensor is located at the bottom of the constant temperature container. When the emptying liquid level sensor sends a signal, the third pump stops discharging the heat exchange medium from the interior of the constant temperature container.

[0142] When the third pump is working, it will discharge the liquid heat exchange medium in the constant temperature container from the constant temperature container. When the emptying liquid level sensor detects no liquid, it means that it has been emptied and no further emptying is required. The emptying liquid level sensor will send an emptying signal and the third pump will stop the discharge action.

[0143] In one embodiment, the liquid level sensor assembly includes:

[0144] A maximum liquid level sensor is located at the top of the constant temperature container. When the maximum liquid level sensor sends a signal, the third pump stops circulating the heat exchange medium into the constant temperature container.

[0145] When the third pump is working to circulate the heat exchange medium into the thermostatic container through the heat exchange pipe, the maximum liquid level sensor determines when to stop injecting the liquid heat exchange medium into the thermostatic container. The maximum liquid level sensor ensures that the injected liquid heat exchange medium does not overflow the thermostatic container.

[0146] In one embodiment, the liquid level sensor assembly includes:

[0147] A standard liquid level sensor, the standard liquid level sensor is located below the maximum liquid level sensor and above the emptying liquid level sensor, wherein a vertical distance between the standard liquid level sensor and the emptying liquid level sensor is much greater than a distance between the standard liquid level sensor and the maximum liquid level sensor;

[0148] When the standard liquid level sensor sends a signal, the third pump starts to circulate the heat exchange medium into the constant temperature container through the heat exchange pipe.

[0149] For liquid heat exchange medium, the reaction chamber needs to be completely or partially submerged in the heat exchange medium when working. The standard liquid level sensor needs to ensure that the liquid heat exchange medium in the constant temperature container is not too little to avoid the reaction chamber being unable to be completely or partially submerged in the heat exchange medium. Therefore, when the liquid level is lower than the standard liquid level sensor, it means that there is insufficient liquid in the constant temperature container and liquid needs to be injected into the constant temperature container. At this time, the third component can be started to inject the liquid into the constant temperature container.

[0150] The above emptying liquid level sensor can realize the discharge of the liquid heat exchange medium in the constant temperature container, and the maximum liquid level sensor and the standard liquid level sensor can cooperate to realize the injection of the liquid heat exchange medium in the constant temperature container. The above three sensors are not shown in the figure, but they are all set in the constant temperature container.

[0151] In one embodiment, the reaction device further includes a first liquid sensor.

[0152] In one example, the first liquid sensor is used to sense liquid inflow and / or liquid discharge. In this case, the first liquid sensor can be disposed at the first port.

[0153] Wherein, when the first liquid sensor sends a signal that there is liquid, the first pump component stops the action of allowing the liquid to enter or discharge the interior of the reaction chamber;

[0154] In other examples, the first liquid sensor is used to perform liquid sensing on a first displacement endpoint of the reaction liquid when the reaction liquid performs the reciprocating flow.

[0155] In one embodiment, the reaction device further includes a second liquid sensor.

[0156] In one example, the second liquid sensor is used to sense liquid inflow and / or liquid discharge. In this case, the second liquid sensor can be disposed at the second port.

[0157] Wherein, when the second liquid sensor sends out a liquid-free signal, the second pump assembly stops the action of discharging the liquid from the interior of the reaction chamber;

[0158] In other examples, the second liquid sensor is used to perform liquid sensing on a second displacement endpoint of the reaction liquid when the reaction liquid performs the reciprocating flow.

[0159] When liquid is introduced, the liquid entering the reaction chamber from the solution bottle can only enter the reaction chamber, but cannot flow out from the second port of the reaction chamber. Therefore, when liquid is introduced, when the second liquid sensor senses the liquid, it will send a liquid signal, and the first pump needs to stop introducing liquid.

[0160] In one implementation of this embodiment, the first liquid sensor and the second liquid sensor can also limit the flow distance of the liquid in the reaction chamber. In this case, both liquid sensors need to be arranged inside the reaction chamber, the first liquid sensor can be close to the first port, and the second liquid sensor can be close to the second port. The positions defined by the two sensors are the flow distance of the liquid in the reaction chamber. Through external pressure control, the liquid in the reaction chamber can flow back and forth in the reaction chamber within the distance defined by the two liquid sensors to react.

[0161] The solution bottle 3 connects the second port with the reaction chamber 5 through the liquid pipeline 18. The second liquid sensor can be arranged on the liquid pipeline 18 or inside the reaction chamber. When arranged inside the reaction chamber, the second liquid sensor can be located close to the second port.

[0162] When liquid is introduced, the first three-way valve 6 connects the first pump 7 with the solution bottle, and the first pump 7 starts to work to extract the gas in the reaction chamber from the first interface 8. Correspondingly, the liquid in the solution bottle 3 will enter the reaction chamber, and the first liquid sensor will sense it. When all the liquid in the solution bottle 3 enters the reaction chamber, the first liquid sensor will sense the liquid and generate a liquid signal. At this time, the liquid introduction is completed and the first pump 7 can stop introducing liquid.

[0163] When discharging liquid, the first three-way valve 6 connects the second pump with the solution bottle, the second pump starts to work, and gas is introduced into the reaction chamber from the second interface 9. Under the action of the gas, the liquid in the reaction chamber is discharged from the reaction chamber and enters the solution bottle. During the whole process, the second liquid sensor senses the liquid. When all the liquid in the reaction chamber enters the solution bottle, the second liquid sensor senses no liquid and generates a liquid-free signal. At this time, the liquid discharging is completed and the second pump can stop discharging liquid.

[0164] In this embodiment, liquid introduction refers to the introduction of liquid (such as in a solution bottle) into the reaction chamber, and liquid discharge refers to the discharge of liquid in the reaction chamber to the outside (such as in a solution bottle).

[0165] In one embodiment, the reaction device further comprises:

[0166] Display screen 1, which is used for an operator to input operation instructions.

[0167] In one embodiment, the reaction device further comprises:

[0168] A control component 2 is used to control the operation of the reaction device.

[0169] The control component interacts with various components or assemblies in the above-mentioned reaction device through signals, thereby realizing overall automation and improving reaction efficiency, rate and accuracy. In one embodiment, the reaction device further includes:

[0170] The weighing device 4 is used to weigh the weight of the solution bottle and control the amount of the reaction liquid entering the reaction chamber through the weighing device. That is, after the weighing device obtains the weight, it can be sent to the control component, and the control component controls the amount of liquid entering the reaction chamber according to the weight change.

[0171] In another implementation of this embodiment, when liquid is introduced, the solution bottle is weighed by a weighing device to determine whether the reaction liquid in the solution bottle has entered the reaction chamber and how much weight of the liquid has entered the reaction chamber. If all the liquid in the solution bottle has entered the reaction chamber, or a predetermined weight of liquid has entered the reaction chamber, the liquid introduction can be stopped. When discharging liquid, if it is determined by the weighing device that all the liquid in the reaction chamber has entered the solution bottle, or a predetermined weight of liquid has entered the reaction chamber, the discharging of liquid can be stopped.

[0172] In one embodiment, the second port is disposed at the bottom of the reaction chamber, and the second port is provided with a second three-way valve 12, and the second three-way valve 12 is respectively connected to the second port, the external discharge pipeline and the solution bottle 3,

[0173] A liquid pipeline 18 is provided between the solution bottle and the second port, and the solution bottle is arranged above the reaction chamber;

[0174] Preferably, the external discharge port 13 on the external discharge pipeline is located at the lowest point of the reaction equipment.

[0175] When the liquid in the reaction chamber needs to be discharged to the outside from the external discharge port 13 , the second three-way valve connects the external discharge pipeline with the second port, and the liquid in the reaction chamber can be discharged from the external discharge port 13 .

[0176] This embodiment also provides a reaction method, comprising:

[0177] Under the action of external force, the reaction liquid is made to flow back and forth in the reaction chamber for a predetermined time to complete the reaction.

[0178] The specific structure of the reaction chamber is described above and will not be described in detail in this embodiment.

[0179] In this embodiment, when the reaction liquid flows back and forth inside the reaction chamber to react, there is no need to use complex equipment, and it can be realized by using the above-mentioned reaction chamber, which is simple to operate. In the above process, there is no contact of moving elements in the reaction chamber, and there will be no problems of wear and damage. The above process is carried out in the reaction chamber. During the reciprocating flow, the overall movement of the liquid is more uniform, the consistency of the movement is stronger, and it is more conducive to reaction and mixing. The speed of the above-mentioned reciprocating flow can be precisely adjusted, and the rhythm can be precisely adjusted, so that the reaction can be achieved accurately and quickly. The above process can better promote the reaction for more fragile reactions and temperature-sensitive reactions, and improve the reaction efficiency and rate.

[0180] In one embodiment, the reaction liquid maintains a constant temperature while flowing back and forth in the reaction chamber for a predetermined time.

[0181] Keep constant temperature during reciprocating flow, and the specific process can refer to the above description.

[0182] In one embodiment, the reaction liquid is caused to reciprocate in the reaction chamber for a predetermined time under the action of an external force to complete the reaction, and the process also includes:

[0183] When the weight change in the solution bottle reaches a preset weighing condition, the introduction of the reaction solution is stopped.

[0184] In one embodiment, the reaction liquid is caused to reciprocate in the reaction chamber for a predetermined time under the action of an external force to complete the reaction, and then the following steps are further included:

[0185] When the weight of the solution bottle stops changing and continues to change for a period of time, the discharge of the reaction solution from the reaction chamber stops.

[0186] When the liquid is added, it is necessary to ensure that the weight of the reaction liquid entering the reaction chamber from the solution bottle meets the requirement; when the liquid is discharged, it is necessary to ensure that sufficient reaction liquid is completely discharged from the reaction chamber; this can be controlled by a weighing device. For details, please refer to the contents of the above embodiments.

[0187] In one embodiment, a reciprocating flow is performed within a predetermined displacement range for a predetermined time;

[0188] Preferably, based on the preset external force control condition, the reaction liquid is caused to reciprocate within the predetermined distance range inside the reaction chamber for a predetermined time to complete the reaction;

[0189] Preferably, the preset external force control condition includes a preset external force magnitude.

[0190] In this embodiment, the external force of the first pump or / and the second pump can be preset so that the reaction liquid can flow back and forth within the predetermined distance range inside the reaction chamber. Specifically, after the reaction liquid enters the reaction chamber, the suction force of the first pump can be controlled so that the reaction liquid flows in the reaction chamber to the first displacement endpoint in the reaction chamber, and then the first pump stops working, the second pump starts working, and the gas is introduced through the second interface 9, and the reaction liquid flows to the second displacement endpoint. The first displacement endpoint and the second displacement endpoint are the predetermined distance range of the liquid.

[0191] This embodiment can also realize the reciprocating flow of the reaction liquid in the reaction chamber within a predetermined distance range through the first liquid sensor and the second liquid sensor. For details, refer to the contents of the above-mentioned embodiments of the reaction equipment.

[0192] The above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that the technical solutions described in the aforementioned embodiments may still be modified, or some of the technical features may be replaced by equivalents. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A reaction device, characterized in that: The reaction equipment at least comprises: A reaction chamber is provided with a first port and a second port, and the reaction chamber is used to contain a reaction liquid. The reaction liquid can flow back and forth inside the reaction chamber under the action of an external force to react.

2. The reaction device according to claim 1, characterized in that: The reaction chamber has at least one curved section, or the reaction chamber has a plurality of continuous curved sections, or the reaction chamber is a coil.

3. The reaction device according to claim 1, characterized in that: The reaction equipment also includes: A constant temperature component is provided, wherein the constant temperature component can keep the reaction liquid at a constant temperature during the reciprocating flow process.

4. The reaction device according to claim 3, characterized in that: The thermostatic assembly comprises: A constant temperature container, used to contain a heat exchange medium, wherein the reaction chamber is located in the constant temperature container and can perform heat exchange with the heat exchange medium; A thermostat is used to heat and / or cool the heat exchange medium so as to keep the constant temperature container at a constant temperature.

5. The reaction device according to claim 4, characterized in that: The heat exchange medium is a fluid.

6. The reaction device according to claim 5, characterized in that: The fluid is water.

7. The reaction device according to claim 4, characterized in that: The thermostat is located at the bottom of the constant temperature container.

8. The reaction device according to any one of claims 1 to 7, characterized in that: The reaction equipment also includes: The inlet and outlet assembly is used to allow external liquid to enter the reaction chamber and to allow liquid inside the reaction chamber to be discharged from the reaction chamber.

9. The reaction device according to claim 8, characterized in that: The inlet and outlet assembly includes a bidirectional pump.

10. The reaction device according to claim 8, characterized in that: The inlet and outlet components include an inlet unit and an outlet unit.

11. The reaction device according to claim 10, characterized in that: The entry unit is used to allow external liquid to enter the reaction chamber; The discharge unit is used to discharge the liquid in the reaction chamber from the reaction chamber.

12. The reaction device according to claim 11, characterized in that The inlet unit and the outlet unit are also used to provide external force to allow the reaction liquid to perform the reciprocating flow.

13. The reaction device according to claim 11, characterized in that: The entry unit comprises: The first pump assembly comprises a first pump, wherein the first pump is communicated with the reaction chamber and is used for allowing liquid to enter the reaction chamber.

14. The reaction device according to claim 13, characterized in that: The first pump is a vacuum pump.

15. The reaction device according to claim 13, characterized in that: The first pump is in communication with the reaction chamber through the first port.

16. The reaction device according to claim 15, characterized in that The first port is located at the top of the reaction chamber.

17. The reaction device according to claim 13, characterized in that: The discharge unit comprises: The second pump assembly comprises a second pump, wherein the second pump is connected to the reaction chamber and is used for discharging liquid from the reaction chamber.

18. The reaction device according to claim 17, characterized in that: The second pump is a positive pressure pump.

19. The reaction device according to claim 17, characterized in that: The discharge unit further comprises: Pressure regulators and gas filters; The pressure regulator is used to adjust the compressed gas pressed into the second pump assembly from the outside to a corresponding gas pressure; The gas filter is used to filter the gas entering the reaction chamber.

20. The reaction device according to claim 13 or 17, characterized in that: The inlet and outlet assembly also includes: A first three-way valve is connected to the first pump, the second pump and the reaction chamber respectively, and is used to connect or close the first pump or the second pump to the reaction chamber.

21. The reaction device according to claim 20, characterized in that The first three-way valve is disposed at the first port.

22. The reaction device according to claim 17, characterized in that: The reaction equipment also includes: A solution bottle is communicated with the reaction chamber and is used to contain liquid entering the reaction chamber and / or liquid discharged from the reaction chamber. The solution bottle is communicated with the reaction chamber through the second port.

23. The reaction device according to claim 22, characterized in that: The solution bottle is connected to the second port through a liquid pipeline.

24. The reaction device according to claim 23, characterized in that The second port is located at the bottom of the reaction chamber, and the position where the liquid pipeline is connected to the solution bottle is located near the top of the reaction chamber.

25. The reaction device according to any one of claims 4 to 7, characterized in that: The reaction device further includes a heat exchange medium component, and the heat exchange medium component includes: A heat exchange pipe, wherein a first end of the heat exchange pipe extends into the bottom of the constant temperature container, and a second end of the heat exchange pipe extends to the outside of the constant temperature container; A third pump is connected to the second end of the heat exchange pipe and is used to circulate the heat exchange medium of the fluid to the interior of the constant temperature container through the heat exchange pipe, and / or to discharge the heat exchange medium of the fluid from the interior of the constant temperature container through the heat exchange pipe.

26. The reaction device according to claim 25, characterized in that The reaction equipment also includes: The liquid level sensor assembly is used to send a sensing signal to activate the third pump.

27. The reaction device according to claim 26, characterized in that The liquid level sensor assembly comprises: The emptying liquid level sensor is located at the bottom of the constant temperature container. When the emptying liquid level sensor sends a signal, the third pump stops discharging the heat exchange medium from the interior of the constant temperature container.

28. The reaction device according to claim 27, characterized in that The liquid level sensor assembly comprises: A maximum liquid level sensor is located at the top of the constant temperature container. When the maximum liquid level sensor sends a signal, the third pump stops inputting the heat exchange medium into the constant temperature container.

29. The reaction device according to claim 28, characterized in that The liquid level sensor assembly comprises: A standard liquid level sensor, the standard liquid level sensor is located below the maximum liquid level sensor and above the emptying liquid level sensor, wherein a vertical distance between the standard liquid level sensor and the emptying liquid level sensor is much greater than a distance between the standard liquid level sensor and the maximum liquid level sensor; When the standard liquid level sensor sends a signal, the third pump starts to circulate the heat exchange medium into the constant temperature container through the heat exchange pipe.

30. The reaction device according to claim 22, characterized in that The reaction equipment also includes: First liquid sensor, The first liquid sensor is used to sense liquid inflow and / or liquid discharge: When the first liquid sensor sends a signal that there is liquid, the first pump component stops the action of allowing the liquid to enter or discharge the reaction chamber; or The first liquid sensor is used to perform liquid sensing on the first displacement endpoint of the reaction liquid when the reaction liquid performs the reciprocating flow.

31. The reaction device according to claim 30, characterized in that The reaction equipment also includes: Second liquid sensor, The second liquid sensor is used to sense liquid inflow and / or liquid discharge; When the second liquid sensor sends a liquid-free signal, the second pump assembly stops the action of discharging the liquid from the reaction chamber; or The second liquid sensor is used to perform liquid sensing on the second displacement endpoint of the reaction liquid when the reaction liquid performs the reciprocating flow.

32. The reaction device according to any one of claims 1 to 7, characterized in that: The reaction equipment also includes: A display screen, wherein the display screen is used for an operator to input operating instructions; and / or A control component is used to control the operation of the reaction device.

33. The reaction device according to claim 22, characterized in that The reaction equipment also includes: A weighing device is used to weigh the weight of the solution bottle and control the amount of liquid entering the reaction chamber through a weight signal provided by the weighing device.

34. The reaction device according to claim 22, characterized in that The second port is arranged at the bottom of the reaction chamber, and a second three-way valve is arranged on the second port. The second three-way valve is also connected with an external discharge pipeline and the solution bottle.

35. The reaction device according to claim 22, characterized in that The solution bottle is arranged above the reaction chamber.

36. The reaction device according to claim 34, characterized in that The external discharge port on the external discharge pipeline is located at the lowest point of the reaction equipment.

37. The reaction device according to claim 4, characterized in that The constant temperature container has a heat-insulating layer.

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