Cooling device for water resistance test of inner surface of medicinal glass container

Abstract

The utility model provides a cooling device for a water resistance test of the inner surface of a medicinal glass container, and relates to the technical field of the water resistance test of the inner surface of the medicinal glass container, the cooling device comprises a cooling box and a fixing piece, the cooling box is a cooling tank used for containing a cooling medium, and the fixing piece is arranged at an opening in the upper end of the cooling tank; according to the medical glass container cooling device, the fixing part is arranged at the opening in the upper end of the cooling tank, the multiple fixing clamping grooves are formed in the fixing part, and the multiple fixing clamping grooves are arranged to be capable of clamping and fixing the multiple medical glass containers to be cooled correspondingly. The fixing part is arranged at the opening in the upper end of the cooling tank, and the multiple fixing clamping grooves formed in the fixing part are used for clamping and fixing the multiple medical glass containers correspondingly; the problem that the erosion liquid contained in the medicinal glass container is polluted due to the fact that the medicinal glass container topples over in the cooling process is effectively solved, and it is ensured that the medicinal glass container containing the erosion liquid can be stably and reliably cooled to the temperature needed by testing.

Description

Technical Field

[0001] The present invention relates to the technical field of water resistance testing of the inner surface of a medicinal glass container, and in particular to a cooling device for testing the water resistance of the inner surface of a medicinal glass container. Background Art

[0002] Pharmaceutical packaging materials can directly contact drugs, and their quality directly affects the safety and stability of drugs. For pharmaceutical glass, one of the main quality criteria is the water resistance of the inner surface: the higher the water resistance, the lower the risk of reaction with drugs, and the higher the quality of the glass.

[0003] Pharmaceutical glass packaging containers are usually produced by molding and tube forming processes. Different production processes have different effects on the quality of glass products, especially on the water resistance of the inner surface of the glass. The water resistance of the inner surface of molded glass containers is basically the same. For different types of glass containers made of tube glass, such as tube injection bottles (or vials), ampoules, pen-type syringe glass sleeves (or flasks), prefilled syringe glass needles, etc., during the process of heating the container to form the container, due to the evaporation and phase separation of alkali metals and borates caused by local heating (such as the bottom stress ring part, the neck), the chemical resistance of the inner surface of the above parts is usually lower than that of the unheated parts of the glass container; in addition, different tube forming processes, such as the flame processing temperature of the bottom and neck, and the annealing temperature and annealing time after the glass container is formed, are different. Therefore, even if the same batch of glass tubes provided by the same manufacturer are used, the tube glass container may have quality differences, which will bring different risks to the packaged drugs. The inner surface water resistance is a method of expressing the ability of the inner surface of a pharmaceutical glass container to withstand water erosion. By measuring the strength of the inner surface of the pharmaceutical glass to resist water erosion, the stability of the chemical properties of the pharmaceutical glass can be reflected. The inner surface water resistance determination method is to inject test water into the test pharmaceutical glass container to a specified capacity, heat it under specified conditions, and measure the degree of water erosion of the inner surface of the pharmaceutical glass container by titrating the erosion liquid.

[0004] The above-mentioned test process requires that the pharmaceutical glass containers containing the corrosive liquid be placed in cooling water for joint cooling. In the process of simultaneously cooling multiple pharmaceutical glass containers, due to the different amounts of corrosive liquid contained in the pharmaceutical glass containers, the pharmaceutical glass containers are prone to tipping over due to unstable center of gravity, so that the corrosive liquid is contaminated, resulting in failure of the water resistance test. Utility Model Content

[0005] A technical problem to be solved by the present disclosure is that the existing cooling device lacks effective fixation, which causes multiple medicinal glass containers containing different amounts of etching liquid to easily tip over during the cooling process, resulting in contamination of the etching liquid and causing the water resistance test to fail.

[0006] In order to solve the above technical problems, the present disclosure provides a cooling device for testing the water resistance of the inner surface of a medicinal glass container, comprising:

[0007] a cooling box having a cooling tank for containing a cooling medium; and

[0008] The fixing piece is arranged at the upper end opening of the cooling groove, and a plurality of fixing slots are arranged on the fixing piece, and the plurality of fixing slots are arranged to respectively clamp and fix a plurality of medicinal glass containers to be cooled.

[0009] In some embodiments, a rubber pad is embedded at the edge of the fixed slot, and the rubber pad is used to clamp the medicinal glass container placed in the fixed slot.

[0010] In some embodiments, the fixing member is a flat fixing plate with a placement hole in the middle of the fixing plate, and a plurality of fixing slots are arranged at circumferential intervals along the placement hole. One ends of the plurality of fixing slots are respectively connected to the placement holes, and the other ends are respectively extended in a direction away from the placement holes.

[0011] In some embodiments, one of the cooling groove and the fixing member is provided with a fixing column, and the other is provided with a limiting hole suitable for inserting the fixing column.

[0012] In some embodiments, the cooling box is provided with an inlet and an outlet, the inlet is used to introduce the cooling medium into the cooling tank, and the outlet is used to guide the cooling medium out of the cooling tank.

[0013] In some embodiments, a liquid inlet area near the inlet and a cooling area near the outlet are formed in the cooling tank. A baffle assembly is provided in the liquid inlet area to enclose a return-shaped flow channel. One end of the flow channel is connected to the inlet, and the other end of the flow channel is connected to the cooling area.

[0014] In some embodiments, the cooling box has a first side wall and a second side wall arranged opposite to each other, the inlet is arranged on the first side wall, the baffle assembly includes a first baffle extending from the first side wall in a direction toward the second side wall and spaced apart from the second side wall, and a second baffle extending from the second side wall in a direction toward the first side wall and spaced apart from the first side wall, and the first baffle and the second baffle are spaced apart in a direction from the inlet toward the outlet.

[0015] In some embodiments, the baffle assembly is integrally formed with the cooling box.

[0016] In some embodiments, the inlet is disposed below the outlet.

[0017] In some embodiments, a first temperature detection unit near the inlet and a second temperature detection unit near the outlet are provided in the cooling tank, and the first temperature detection unit and the second temperature detection unit are respectively used to detect the temperature of the cooling medium in the cooling tank.

[0018] Through the above technical scheme, in the cooling device provided by the present invention, a fixing piece is arranged at the upper end opening of the cooling groove, and a plurality of medicinal glass containers are respectively clamped and fixed by using a plurality of fixing slots arranged on the fixing piece, thereby effectively preventing the medicinal glass containers from tipping over during the cooling process and causing the etching liquid contained therein to be contaminated, thereby ensuring that the medicinal glass containers containing the etching liquid can be stably and reliably cooled to the temperature required for the test. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] In order to more clearly illustrate the embodiments of the present disclosure or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present disclosure. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0020] Figure 1 is a top view of a cooling box disclosed in an embodiment of the present disclosure;

[0021] Figure 2 is a top view of a fixing member disclosed in an embodiment of the present disclosure;

[0022] Figure 3 It is a side view of a cooling device for testing the water resistance of the inner surface of a medicinal glass container disclosed in an embodiment of the present disclosure.

[0023] Description of reference numerals:

[0024] 100, cooling box; 101, liquid inlet area; 102, cooling area; 110, cooling trough; 111, fixing column; 120, inlet; 130, outlet; 140, first side wall; 150, second side wall; 160, first temperature detection unit; 170, second temperature detection unit; 200, fixing piece; 210, fixing slot; 211, rubber pad; 220, placement hole; 230, limiting hole; 300, medicinal glass container; 400, baffle assembly; 410, first baffle; 420, second baffle. DETAILED DESCRIPTION

[0025] The following is a further detailed description of the embodiments of the present disclosure in conjunction with the accompanying drawings and examples. The detailed description of the following embodiments and the accompanying drawings are used to exemplarily illustrate the principles of the present disclosure, but cannot be used to limit the scope of the present disclosure. The present disclosure can be implemented in many different forms and is not limited to the specific embodiments disclosed herein, but includes all technical solutions that fall within the scope of the claims.

[0026] The present disclosure provides these embodiments to make the present disclosure thorough and complete, and to fully express the scope of the present disclosure to those skilled in the art. It should be noted that unless otherwise specifically stated, the relative arrangement of the parts and steps, the composition of the materials, the numerical expressions and the numerical values ​​set forth in these embodiments should be interpreted as being merely exemplary, and not as limiting.

[0027] It should be noted that, in the description of the present disclosure, unless otherwise specified, the meaning of "multiple" is greater than or equal to two; the terms "upper" and "lower" and the like indicate positions or positional relationships only for the convenience of describing the present disclosure and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific position, be constructed and operated in a specific position, and therefore cannot be understood as a limitation of the present disclosure. When the absolute position of the object being described changes, the relative positional relationship may also change accordingly.

[0028] In addition, the words "first", "second" and similar words used in this disclosure do not indicate any order, quantity or importance, but are only used to distinguish different parts. The words "include" or "comprise" and similar words mean that the elements before the word include the elements listed after the word, and do not exclude the possibility of including other elements.

[0029] It should also be noted that in the description of the present disclosure, unless otherwise clearly specified and limited, the terms "installed", "connected", and "connected" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be directly connected or indirectly connected through an intermediate medium. For ordinary technicians in this field, the specific meanings of the above terms in the present disclosure can be understood according to the specific circumstances. When a specific device is described as being located between a first device and a second device, there may or may not be an intermediate device between the specific device and the first device or the second device.

[0030] All terms used in the present disclosure have the same meanings as those understood by those of ordinary skill in the art to which the present disclosure belongs, unless otherwise specifically defined. It should also be understood that terms defined in general dictionaries, for example, should be interpreted as having meanings consistent with their meanings in the context of the relevant technology, and should not be interpreted in an idealized or extremely formal sense, unless explicitly defined as such herein.

[0031] Technologies, methods, and equipment known to ordinary technicians in the relevant art may not be discussed in detail, but where appropriate, the technologies, methods, and equipment should be considered part of the specification.

[0032] See also Figure 1 and Figure 2The present disclosure provides a cooling device for testing the water resistance of the inner surface of a medicinal glass container, comprising a cooling box 100 and a fixing member 200. The cooling box 100 has a cooling trough 110 for containing a cooling medium. The fixing member 200 is arranged at the upper end opening of the cooling trough 110. The fixing member 200 is provided with a plurality of fixing slots 210. The plurality of fixing slots 210 are arranged to be able to respectively clamp and fix a plurality of medicinal glass containers 300 to be cooled.

[0033] In the technical solution provided by the present disclosure, a fixing member 200 is provided at the upper end opening of the cooling groove 110, and a plurality of medicinal glass containers 300 are respectively clamped and fixed by using a plurality of fixing slots 210 provided on the fixing member 200, thereby effectively preventing the medicinal glass containers 300 from tipping over during the cooling process and causing the corrosive liquid contained therein to be contaminated, thereby ensuring that the medicinal glass containers 300 containing the corrosive liquid can be stably and reliably cooled to the temperature required for the test.

[0034] In the present disclosure, the cooling medium may be any suitable medium capable of cooling the medicinal glass container 300 and the etching liquid contained therein. From a cost perspective, water is used as the cooling medium.

[0035] It is understandable that in the present disclosure, the medicinal glass container 300 to be cooled and filled with the etching liquid can be fixed to the fixing slot 210 of the fixing member 200 in any appropriate form. For example, the fixing member 200 itself is made of a relatively soft material, and the clamping mouth of the fixing slot 210 is slightly smaller than the outer diameter of the medicinal glass container 300, so that the medicinal glass container 300 can be reliably fixed without damaging the medicinal glass container 300. In some embodiments, a rubber pad 211 is embedded at the edge of the fixing slot 210, and the rubber pad 211 is used to clamp the medicinal glass container 300 placed in the fixing slot 210. By embedding the rubber pad 211 at the edge of the fixing slot 210, the medicinal glass container 300 is reliably fixed while preventing damage to the medicinal glass container 300.

[0036] In some embodiments, the fixing member 200 is a flat fixing plate, a placement hole 220 is provided in the middle of the fixing plate, a plurality of fixing slots 210 are arranged at intervals along the circumference of the placement hole 220, one end of the plurality of fixing slots 210 are respectively connected to the placement holes 220, and the other ends are respectively extended in a direction away from the placement holes 220. In specific operation, the medicinal glass container 300 is placed into the placement hole 220 from top to bottom and is inserted into the fixing slot 210 connected to the placement hole 220.

[0037] It is understandable that in order to avoid mutual interference between multiple medicinal glass containers 300 to be cooled, when the number of medicinal glass containers 300 is significantly less than the number of fixed slots 210, the medicinal glass containers 300 can be placed in a relatively dispersed manner. Figure 2 As shown, in some embodiments, eight fixing slots 210 are provided on the fixing member 200 , and four medicinal glass containers 300 to be cooled are arranged in a mutually spaced manner to ensure that the cooling medium in the cooling slot 110 has a good cooling effect on each medicinal glass container 300 .

[0038] In the present disclosure, the fixing member 200 and the cooling box 100 can be fixed in any appropriate form, so that the plurality of medicinal glass containers 300 fixed to the fixing member 200 are stably inserted into the cooling slot 110 of the cooling box 100 for cooling. In some embodiments, one of the cooling slot 110 and the fixing member 200 is provided with a fixing column 111, and the other is provided with a limiting hole 230 suitable for inserting the fixing column 111. In some embodiments, see Figure 1 As shown, the cooling groove 110 is a square groove, and upwardly extending fixing columns 111 are respectively arranged at the four corners of the square groove. The fixing member 200 is provided with a limiting hole 230 suitable for inserting the fixing column 111. During installation, the fixing member 200 is placed at the upper opening of the cooling groove 110, and the fixing column 111 is inserted into the limiting hole 230, thereby completing the arrangement of the fixing member 200 at the upper opening of the cooling groove 110.

[0039] It should be noted that in the present disclosure, if the cooling medium in the cooling tank 110 does not flow, it will not only affect the cooling efficiency of the medicinal glass container 300, but may also cause the cooling temperature of multiple medicinal glass containers 300 to be inconsistent and the cooling to be uneven. To this end, in some embodiments, the cooling box 100 is provided with an inlet 120 and an outlet 130, the inlet 120 is used to introduce the cooling medium into the cooling tank 110, and the outlet 130 is used to guide the cooling medium out of the cooling tank 110. By providing the inlet 120 and the outlet 130, a flowing cooling medium can be formed in the cooling tank 110, which can not only improve the cooling efficiency of the medicinal glass container 300, but also avoid the phenomenon of uneven cooling of the medicinal glass container 300, ensuring that multiple medicinal glass containers 300 can be quickly cooled to the required temperature for testing.

[0040] In some embodiments, a liquid inlet area 101 near the inlet 120 and a cooling area 102 near the outlet 130 are formed in the cooling tank 110. A baffle assembly 400 is provided in the liquid inlet area 101 to enclose a return-shaped flow channel, one end of the flow channel is connected to the inlet 120, and the other end of the flow channel is connected to the cooling area 102. By providing a return-shaped flow channel, the cooling medium from the inlet 120 is buffered to prevent the excessive pressure of the cooling medium from causing the medicinal glass container 300 to move or even tip over.

[0041] In the present disclosure, the baffle assembly 400 may adopt any appropriate form to form a return-shaped flow channel. In some embodiments, the cooling box 100 has a first side wall 140 and a second side wall 150 disposed opposite to each other, the inlet 120 is disposed on the first side wall 140, the baffle assembly 400 includes a first baffle 410 extending from the first side wall 140 in a direction toward the second side wall 150 and spaced from the second side wall 150, and a second baffle 420 extending from the second side wall 150 in a direction toward the first side wall 140 and spaced from the first side wall 140, and the first baffle 410 and the second baffle 420 are spaced from each other in a direction from the inlet 120 to the outlet 130.

[0042] In some embodiments, the baffle assembly 400 is integrally formed with the cooling box 100. By arranging the baffle assembly 400 and the cooling box 100 as an integrally formed unit, the baffle assembly 400 and the cooling box 100 have the advantages of being firm and stable, and the gap problem that may exist when multiple plates are spliced ​​together is avoided.

[0043] In some embodiments, see Figure 3 The inlet 120 is arranged below the outlet 130. When the cooling device is used, the cooling medium enters the cooling tank 110 through the inlet 120, and when the liquid level of the cooling medium in the cooling tank 110 rises to the height of the outlet 130, the cooling medium overflows out of the cooling tank 110 through the outlet 130.

[0044] In some embodiments, a first temperature detection unit 160 near the inlet 120 and a second temperature detection unit 170 near the outlet 130 are disposed in the cooling tank 110 , and the first temperature detection unit 160 and the second temperature detection unit 170 are respectively used to detect the temperature of the cooling medium in the cooling tank 110 .

[0045] It can be understood that the first temperature detection unit 160 near the inlet 120 detects the initial temperature of the cooling medium, while the second temperature detection unit 170 near the outlet 130 detects the temperature of the cooling medium that has undergone heat exchange with multiple medicinal glass containers 300. Therefore, the cooling effect on the medicinal glass container 300 can be determined by the temperature difference of the cooling medium at these two positions.

[0046] So far, various embodiments of the present disclosure have been described in detail. In order to avoid obscuring the concept of the present disclosure, some details known in the art are not described. Based on the above description, those skilled in the art can fully understand how to implement the technical solution disclosed here.

[0047] Although some specific embodiments of the present disclosure have been described in detail by way of examples, it should be understood by those skilled in the art that the above examples are for illustration only and are not intended to limit the scope of the present disclosure. It should be understood by those skilled in the art that the above embodiments may be modified or some technical features may be replaced by equivalents without departing from the scope and spirit of the present disclosure. In particular, the various technical features mentioned in the various embodiments may be combined in any manner as long as there is no structural conflict.

Claims

1. A cooling device for testing the water resistance of the inner surface of a medicinal glass container, characterized in that: include: A cooling box (100), wherein the cooling box (100) has a cooling tank (110) for containing a cooling medium; and A fixing member (200), the fixing member (200) being arranged at the upper end opening of the cooling groove (110), the fixing member (200) being provided with a plurality of fixing slots (210), the plurality of fixing slots (210) being arranged to be able to respectively clamp and fix a plurality of medicinal glass containers (300) to be cooled.

2. The cooling device for testing the water resistance of the inner surface of a medicinal glass container according to claim 1, characterized in that: A rubber pad (211) is nested at the edge of the fixed card slot (210), and the rubber pad (211) is used to clamp the medicinal glass container (300) placed in the fixed card slot (210).

3. The cooling device for testing the water resistance of the inner surface of a medicinal glass container according to claim 1, characterized in that: The fixing member (200) is a flat fixing plate, a placement hole (220) is provided in the middle of the fixing plate, the plurality of fixing slots (210) are arranged at intervals along the circumference of the placement hole (220), one end of the plurality of fixing slots (210) is respectively connected to the placement hole (220), and the other end is respectively extended in a direction away from the placement hole (220).

4. The cooling device for testing the water resistance of the inner surface of a medicinal glass container according to claim 3, characterized in that: One of the cooling groove (110) and the fixing member (200) is provided with a fixing column (111), and the other is provided with a limiting hole (230) suitable for inserting the fixing column (111).

5. The cooling device for testing the water resistance of the inner surface of a medicinal glass container according to any one of claims 1 to 4, characterized in that: The cooling box (100) is provided with an inlet (120) and an outlet (130), wherein the inlet (120) is used to introduce a cooling medium into the cooling tank (110), and the outlet (130) is used to guide the cooling medium out of the cooling tank (110).

6. The cooling device for testing the water resistance of the inner surface of a medicinal glass container according to claim 5, characterized in that: The cooling trough (110) is formed with a liquid inlet area (101) close to the inlet (120) and a cooling area (102) close to the outlet (130); a baffle assembly (400) is provided in the liquid inlet area (101) for enclosing a return-shaped flow channel, one end of the flow channel is connected to the inlet (120), and the other end of the flow channel is connected to the cooling area (102).

7. The cooling device for testing the water resistance of the inner surface of a medicinal glass container according to claim 6, characterized in that: The cooling box (100) has a first side wall (140) and a second side wall (150) which are arranged opposite to each other, the inlet (120) is arranged on the first side wall (140), the baffle assembly (400) includes a first baffle (410) extending from the first side wall (140) in a direction toward the second side wall (150) and spaced apart from the second side wall (150), and a second baffle (420) extending from the second side wall (150) in a direction toward the first side wall (140) and spaced apart from the first side wall (140), the first baffle (410) and the second baffle (420) being spaced apart in a direction from the inlet (120) toward the outlet (130).

8. The cooling device for testing the water resistance of the inner surface of a medicinal glass container according to claim 6, characterized in that: The baffle assembly (400) and the cooling box (100) are integrally formed.

9. The cooling device for testing the water resistance of the inner surface of a medicinal glass container according to claim 5, characterized in that: The inlet (120) is arranged below the outlet (130).

10. The cooling device for testing the water resistance of the inner surface of a medicinal glass container according to claim 5, characterized in that: The cooling tank (110) is provided with a first temperature detection unit (160) close to the inlet (120) and a second temperature detection unit (170) close to the outlet (130); the first temperature detection unit (160) and the second temperature detection unit (170) are respectively used to detect the temperature of the cooling medium in the cooling tank (110).

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