Istradefylline crystallization device
By designing the Itu theophylline crystallization device, the combination of the sliding sleeve, stirring rod and scraper, combined with the synchronous movement of the limit slider and the slide chute, the problem of theophylline crystallization climbing on the inner wall of the mixing tank is solved, and the crystallization is achieved Effective removal and precipitation.
Patent Information
- Application Number
- CN202323593122.X
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2023-12-27
- Publication Date
- 2024-12-31
- Estimated Expiration
- 2033-12-27
AI Technical Summary
The problem of theophylline crystallization clinging on the inner wall of the stirring container cannot be effectively removed in the prior art, resulting in the inability to completely precipitate and carry out the crystal.
A kind of crystallization device of the icylate is designed, including a mixing tank, support rod, sliding sleeve, stirring rod, scraper, gear, limit slider and drive assembly. Through the cooperation of the sliding sleeve and stirring rod, the scraper pair is driven The inner wall of the mixing tank is scraped off, and the limit slider and chute rotate and move simultaneously to ensure full crystal removal.
It effectively solves the problem that theophylline crystals cling to the inner wall of the container. Through the cooperation of the scraper and the limit slider, the crystals on the inner wall can be completely scraped off to ensure that the crystals can be precipitated and discharged smoothly.
Smart Images
Figure CN222266187U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the technical field of istradefylline preparation, in particular to an istradefylline crystallization device. Background Art
[0002] Theophylline is an organic compound that can reduce smooth muscle tension and dilate the airways; it can promote the release of endogenous adrenaline and norepinephrine, relax airway smooth muscles; inhibit the release of calcium ions from the endoplasmic reticulum of smooth muscles, reduce the intracellular calcium ion concentration and produce airway dilation. Theophylline can be used to treat bronchial asthma, acute bronchitis, asthmatic bronchitis, obstructive pulmonary emphysema, etc. to relieve wheezing symptoms. It is also suitable for the symptoms of bronchospasm associated with chronic bronchitis and emphysema.
[0003] The extraction of theophylline requires a series of operations such as adding various reagents, stirring and cooling, and then theophylline crystals will precipitate. The precipitated theophylline crystals will settle at the bottom of the container, but some of the crystals will cling to the inner wall of the container. These crystals cannot be driven to sink by the stirring water flow alone. Therefore, a istradefylline crystallization device is proposed to address the above problems. Utility Model Content
[0004] The utility model aims at the technical problems existing in the prior art and provides an istradefylline crystallization device, which can solve the problem that theophylline crystals adhere to the inner wall of a container.
[0005] The utility model solves the above-mentioned technical problem with the following technical solution: a istradefylline crystallization device, comprising a stirring tank and a delivery pump, wherein a support rod is fixedly connected inside the stirring tank, a sleeve is slidably connected to the outside of the support rod, a stirring rod is fixedly connected to the bottom of the sleeve, and scrapers are fixedly connected to the stirring rod in a circular array on both the upper and lower sides, a gear is rotatably connected inside the stirring tank, a limiting slider is fixedly connected to the inner side of the sleeve, a limiting slide groove is provided on the outer surface of the support rod, a driving assembly and a feed pipe are fixedly connected to the top of the stirring tank, a waste liquid pipe is fixedly connected to the side of the stirring tank, a cooler is sleeved on the outer surface of the feed pipe, and a discharge port is provided at the bottom of the stirring tank.
[0006] Preferably, the sliding sleeve and the stirring rod are movably connected inside the stirring tank, and the stirring rod surrounds the outside of the support rod and is movably connected to the support rod.
[0007] Preferably, the outer surface of the sliding sleeve is in a tooth shape, and a corresponding bayonet is provided on the inner side of the gear.
[0008] Preferably, the cross section of the outer ring of the stirring rod is trapezoidal, and the scraper is in the shape of a triangular prism.
[0009] Preferably, the limiting sliding block is slidably connected inside the limiting sliding groove, and the driving assembly drives the gear to rotate.
[0010] Preferably, the other end of the feed pipe is fixedly connected to the delivery pump, and the waste liquid pipe is located in the middle of the stirring tank.
[0011] Preferably, when the driving assembly drives the gear to rotate, the limiting slider slides inside the limiting sliding groove, and the sliding sleeve moves up and down and rotates synchronously.
[0012] The beneficial effect of the utility model is that the cooperation of the sliding sleeve, the stirring rod, the scraper and the limiting slider can effectively solve the problem that theophylline crystals will cling to the inner wall of the container. The stirring rod and the scraper can be conveniently scraped off the crystals clinging to the inner wall. The limiting slider and the limiting groove can make the sliding sleeve move up and down synchronously when rotating, so as to comprehensively scrape off the crystals on the inner wall. BRIEF DESCRIPTION OF THE DRAWINGS
[0013] Figure 1 It is a schematic diagram of the three-dimensional structure of the utility model;
[0014] Figure 2 It is a side sectional view of the utility model;
[0015] Figure 3 For this utility model Figure 2 Enlarged view of point A in the middle;
[0016] Figure 4 This is a top sectional view of the utility model;
[0017] Figure 5 This is a new explosion diagram of the utility model.
[0018] In the accompanying drawings, the components represented by the reference numerals are listed as follows:
[0019] 1. Mixing tank, 2. Support rod, 3. Sliding sleeve, 4. Mixing rod, 5. Scraper, 6. Gear, 7. Limiting slider, 8. Limiting slide, 9. Driving assembly, 10. Conveying, 11. Feed pipe, 12. Waste liquid pipe, 13. Cooler, 14. Discharge port. DETAILED DESCRIPTION
[0020] The following will be combined with the drawings in the embodiments of the present application to clearly and completely describe the technical solutions in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative work are within the scope of protection of this application.
[0021] like Figures 1 to 5As shown, the utility model provides an istradefylline crystallization device, including a stirring tank 1 and a delivery pump 10, a support rod 2 is fixedly connected inside the stirring tank 1, a sleeve 3 is slidably connected to the outside of the support rod 2, a stirring rod 4 is fixedly connected to the bottom of the sleeve 3, and scrapers 5 are fixedly connected to the stirring rod 4 on both sides of the upper and lower sides in a circular array, a gear 6 is rotatably connected inside the stirring tank 1, a limited position slider 7 is fixedly connected to the inner side of the sleeve 3, a limited position slide groove 8 is provided on the outer surface of the support rod 2, a driving component 9 and a feeding pipe 11 are fixedly connected to the top of the stirring tank 1, a waste liquid pipe 12 is fixedly connected to the side of the stirring tank 1, a cooler 13 is sleeved on the outer surface of the feeding pipe 11, and the stirring tank 1 A discharge port 14 is provided at the bottom; by starting the delivery pump 10, the solution is pumped into the stirring tank 1 for mixing, and then the driving component 9 is started. The driving component 9 drives the gear 6 to drive the sleeve 3 to rotate to stir the solution, and then the driving component 9 is closed and allowed to stand for crystals to precipitate. After a certain period of time, the waste liquid pipe 12 is opened to discharge the waste liquid, and then the driving component 9 is started again to drive the sleeve 3 to rotate. The limiting slider 7 on the inner side of the sleeve 3 slides in the limiting groove 8 to drive the sleeve 3 to rotate while moving up and down, so as to scrape off the crystals attached to the inner wall of the stirring tank 1, and then the liquid containing the crystals can be discharged from the discharge port 14 for drying.
[0022] like Figure 2 , Figure 3 As shown, the sleeve 3 and the stirring rod 4 are movably connected inside the stirring tank 1, the stirring rod 4 surrounds the outside of the support rod 2 and is movably connected to the support rod 2, the outer surface of the sleeve 3 is in a toothed shape, and a corresponding bayonet is provided on the inner side of the gear 6, the outer ring cross-section of the stirring rod 4 is trapezoidal, and the scraper 5 is in a triangular prism shape; by arranging the stirring rod 4, the stirring rod 4 can stir the solution inside the stirring tank 1, and at the same time, the crystals attached to the inner wall of the stirring tank 1 can be scraped off after crystallization, the outer surface of the sleeve 3 is in a toothed shape and the inner side of the gear 6 is provided with a corresponding bayonet, the gear 6 can move freely up and down when the sleeve 3 drives the gear 6 to rotate, the outer ring cross-section of the stirring rod 4 is set to a trapezoidal shape and the scraper 5 is set to a triangular prism shape, which is convenient for fitting the inner wall of the stirring tank 1 and better scraping.
[0023] like Figure 2 , Figure 4As shown, the limit slider 7 is slidably connected to the inside of the limit slide groove 8, the driving component 9 drives the gear 6 to rotate, the other end of the feed pipe 11 is fixedly connected to the delivery pump 10, and the waste liquid pipe 12 is located in the middle of the stirring tank 1. When the driving component 9 drives the gear 6 to rotate, the limit slider 7 slides in the limit slide groove 8, and the sleeve 3 moves up and down and rotates synchronously; the limit slider 7 slides in the limit slide groove 8, so that the sleeve 3 can move up and down reciprocatingly, and by setting the delivery pump 10, the delivery pump 10 can conveniently pump the raw material solution into the stirring tank 1, and the waste liquid pipe 12 is set in the middle of the stirring tank 1 to prevent the discharge of the waste liquid together with the crystallized liquid. When the driving component 9 drives the gear 6 to rotate, it drives the sleeve 3 to rotate, and at the same time, the limit slider 7 inside the sleeve 3 slides in the limit slide groove 8, so that the sleeve 3 can move up and down while rotating.
[0024] The working principle and use process of the utility model are as follows: when working, the delivery pump 10 is started to pump the solution into the stirring tank 1 for mixing, and then the driving component 9 is started, and the driving component 9 drives the gear 6 to drive the sleeve 3 to rotate to stir the solution, and then the driving component 9 is closed, and the crystals are allowed to stand and precipitate. After a certain period of time, the waste liquid pipe 12 is opened to discharge the waste liquid, and then the driving component 9 is started again to drive the sleeve 3 to rotate, and the limiting slider 7 on the inner side of the sleeve 3 slides in the limiting slide groove 8 to drive the sleeve 3 to rotate while moving up and down, so as to scrape off the crystals attached to the inner wall of the stirring tank 1, and then the liquid containing the crystals can be discharged from the discharge port 14 for drying.
[0025] It should be noted that in the above embodiments, the description of each embodiment has its own emphasis, and for parts that are not described in detail in a certain embodiment, reference can be made to the relevant descriptions of other embodiments.
[0026] Although the preferred embodiments of the utility model have been described, those skilled in the art may make other changes and modifications to these embodiments once they have learned the basic creative concept. Therefore, the appended claims are intended to be interpreted as including the preferred embodiments and all changes and modifications falling within the scope of the utility model.
[0027] Obviously, those skilled in the art can make various changes and modifications to the present invention without departing from the spirit and scope of the present invention. Thus, if these modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include these modifications and variations.
Claims
1. An istradefylline crystallization device, comprising a stirring tank (1) and a delivery pump (10), characterized in that: The stirring tank (1) is fixedly connected to a support rod (2) inside, and a sleeve (3) is slidably connected to the outside of the support rod (2), and a stirring rod (4) is fixedly connected to the bottom of the sleeve (3), and scrapers (5) are fixedly connected to the upper and lower sides of the stirring rod (4) in a circular array, and a gear (6) is rotatably connected inside the stirring tank (1), and a limiting slider (7) is fixedly connected to the inside of the sleeve (3), and a limiting slide groove (8) is provided on the outer surface of the support rod (2), and a driving component (9) and a feeding pipe (11) are fixedly connected to the top of the stirring tank (1), and a waste liquid pipe (12) is fixedly connected to the side of the stirring tank (1), and a cooler (13) is sleeved on the outer surface of the feeding pipe (11), and a discharge port (14) is provided at the bottom of the stirring tank (1).
2. The istradefylline crystallization device according to claim 1, characterized in that: The sliding sleeve (3) and the stirring rod (4) are movably connected inside the stirring tank (1); the stirring rod (4) surrounds the outside of the support rod (2) and is movably connected to the support rod (2).
3. The istradefylline crystallization device according to claim 1, characterized in that: The outer surface of the sliding sleeve (3) is in the shape of a tooth, and a corresponding tooth opening is arranged on the inner side of the gear (6).
4. The istradefylline crystallization device according to claim 1, characterized in that: The outer ring cross section of the stirring rod (4) is trapezoidal, and the scraper (5) is in the shape of a triangular prism.
5. The istradefylline crystallization device according to claim 1, characterized in that: The limiting slide block (7) is slidably connected inside the limiting slide groove (8), and the driving component (9) drives the gear (6) to rotate.
6. The istradefylline crystallization device according to claim 1, characterized in that: The other end of the feed pipe (11) is fixedly connected to the delivery pump (10), and the waste liquid pipe (12) is located in the middle of the stirring tank (1).
7. The istradefylline crystallization device according to claim 1, characterized in that: When the driving assembly (9) drives the gear (6) to rotate, the limiting slider (7) slides inside the limiting slide groove (8), and the sliding sleeve (3) moves up and down and rotates synchronously.