Palonosetron hydrochloride crystallization device

Abstract

The utility model discloses a palonosetron hydrochloride crystallization device which is applied to the technical field of biological pharmacy and comprises a bottom plate, the top of the bottom plate is fixedly connected with an L-shaped plate, the top of the bottom plate is provided with a containing barrel, a crystallization mechanism is arranged between the containing barrel and the bottom plate, a stirring assembly is arranged between the L-shaped plate and the containing barrel, and the stirring assembly is connected with the L-shaped plate. The crystallization mechanism is arranged, a containing barrel is placed on the top of a heat conduction plate, then a palonosetron hydrochloride medicine needing to be crystallized is injected into the containing barrel, then a heating pipe is started, the heating pipe can heat the containing barrel, after heating work is finished, a sealing cover on a liquid adding pipe is screwed off, and the liquid adding pipe is sealed. Then cooling water is injected into the liquid injection cavity through the liquid adding pipe, and at the moment, the cooling water in the liquid injection cavity exchanges heat with the palonosetron hydrochloride medicine in the containing barrel for cooling, so that the palonosetron hydrochloride medicine is slowly cooled and crystallized.

Description

Technical Field

[0001] The utility model belongs to the technical field of biopharmaceuticals, and particularly relates to a palonosetron hydrochloride crystallization device. Background Art

[0002] Palonosetron hydrochloride is a 5-HT3 receptor antagonist and an antiemetic used to prevent and treat nausea and vomiting caused by tumor radiotherapy, chemotherapy, and surgery. It can effectively reduce the incidence of nausea and vomiting. Compared with other antiemetics, palonosetron hydrochloride has better effects and longer duration of action.

[0003] The Chinese utility model patent currently announced as CN214415639U discloses a crystallization device for biomedical preparation, which places a reaction container on a base plate and controls a first motor to drive a threaded rod to rotate. Two sliders on the outer side of the threaded rod are moved laterally by the thrust of the thread, so that the two clamping plates move toward each other to clamp the reaction container, maintain the stability of the reaction container, and prevent the container from shaking during crystallization and stirring. The support seat at the bottom of the base plate is a rubber seat with a large friction coefficient, which can maintain the stability of the entire crystallization device. Before placing the reaction container, the electric push rod is controlled to push the guide rod downward, so that the sleeve is driven by the reaction force to drive the top plate to rise, to prevent the rotating rod from blocking the placement space of the container. When the reaction container is placed and fixed, the rotating rod is controlled to move down to the inside of the reaction container, and normal crystallization operation can be performed, thereby achieving the purpose of convenient use.

[0004] Although this patent has the feature of allowing cooling water to enter the rotating rod from the connector above the fixed frame and flow out from the dripping hole, so that the steps of dripping cooling water and stirring are automatically performed synchronously, the crystallization process is smooth and uniform, and the distance between the clamps and the height of the top plate can be adjusted at will, and can be adapted to reaction vessels of different sizes, thus achieving the purpose of convenient use, the cooling water is directly added to the reaction vessel, so that the cooling water is in direct contact with the drug in the reaction vessel, which will affect the concentration of the drug and cause a decrease in product quality. Utility Model Content

[0005] The utility model aims to provide a palonosetron hydrochloride crystallization device, which solves the problem that cooling water is directly added into a reaction container in the existing palonosetron hydrochloride crystallization device, so that the cooling water is in direct contact with the medicine in the reaction container, thereby affecting the concentration of the medicine and causing a decrease in product quality.

[0006] The above technical objectives of the utility model are achieved through the following technical solutions: a palonosetron hydrochloride crystallization device, comprising a bottom plate, an L-shaped plate fixedly connected to the top of the bottom plate, a containing barrel arranged on the top of the bottom plate, a crystallization mechanism arranged between the containing barrel and the bottom plate, and a stirring assembly arranged between the L-shaped plate and the containing barrel;

[0007] The crystallization mechanism includes a mounting groove, a heating tube, a heat conduction plate, a liquid injection cavity, a liquid adding tube, a liquid draining tube and a sealing cover. The mounting groove is opened at the top of the bottom plate, the heating tube is arranged inside the mounting groove, the heat conduction plate is bolted to the inside of the mounting groove and is flush with the top of the bottom plate, the liquid injection cavity is opened in the side wall of the containing barrel, one end of the liquid adding tube and the liquid draining tube are fixedly connected to the side wall of the containing barrel and are communicated with the liquid injection cavity, and the sealing cover is spirally connected to the liquid adding tube and the other end of the liquid adding tube.

[0008] The above technical scheme is adopted, by setting an installation groove, a heating tube, a heat conduction plate, a liquid injection chamber, a liquid adding tube, a liquid discharge tube, a sealing cover and a stirring assembly. When in use, the containing barrel is placed on the top of the heat conduction plate, and then the palonosetron hydrochloride drug that needs to be crystallized is injected into the containing barrel, and then the heating tube is started. The heating tube will heat the containing barrel. When the heating work is completed, the sealing cover on the liquid adding tube is unscrewed, and then cooling water is injected into the liquid injection chamber through the liquid adding tube. At this time, the cooling water inside the liquid injection chamber will exchange heat and cool the palonosetron hydrochloride drug inside the containing barrel, so that the palonosetron hydrochloride drug will slowly cool down and crystallize. By setting the stirring assembly, the heating rate of the palonosetron hydrochloride drug in the containing barrel can be improved, and at the same time, the working efficiency of cooling and crystallizing the palonosetron hydrochloride drug in the containing barrel can be improved.

[0009] The utility model is further configured as follows: the stirring assembly includes a servo motor, a screw rod, a T-shaped plate, a stirring motor, a stirring shaft and a stirring rod, the servo motor is bolted to the top of the L-shaped plate, one end of the screw rod is connected to the top of the bottom plate by a bearing, the other end of the screw rod passes through the T-shaped plate and is fixedly connected to the output end of the servo motor, the T-shaped plate is spirally connected to the periphery of the screw rod, the stirring motor is bolted to the top of the T-shaped plate, the stirring shaft passes through the T-shaped plate and is fixedly connected to the output end of the stirring motor, and a plurality of stirring rods are fixedly connected to the side wall of the stirring shaft and are evenly distributed.

[0010] The above technical solution is adopted by setting a servo motor, a screw, a T-shaped plate, a stirring motor, a stirring shaft and a stirring rod, and starting the servo motor to drive the screw to rotate. Since the T-shaped plate is spirally connected to the screw, the T-shaped plate will move up and down on the screw. At the same time, the T-shaped plate will drive the stirring motor and the stirring shaft to move up and down, which is convenient for separating the stirring shaft and the stirring rod from the containing barrel to meet the usage requirements in different situations. Starting the stirring motor drives the stirring shaft and the stirring rod to rotate, thereby increasing the heating rate of the palonosetron hydrochloride drug in the containing barrel, and at the same time improving the working efficiency of cooling and crystallizing the palonosetron hydrochloride drug in the containing barrel.

[0011] The utility model is further configured as follows: two through holes are opened on the top of the T-shaped plate and are located on both sides of the screw rod, a guide rod is slidably connected inside the through hole, and two ends of the guide rod are respectively fixedly connected to the top of the bottom plate and the inner top of the L-shaped plate.

[0012] By adopting the above technical solution, through holes and guide rods are set, when the T-shaped plate moves up and down on the screw rod, the through holes on the T-shaped plate will move along the trajectory of the guide rod at the same time, which can limit and guide the moving trajectory of the T-shaped plate, greatly improving the stability of the T-shaped plate during movement.

[0013] The utility model is further configured as follows: three ribbon stirring blades are arranged on the periphery of the stirring shaft, and the three ribbon stirring blades are respectively fixedly connected to one end of the stirring rod.

[0014] By adopting the above technical solution, a ribbon stirring blade is provided, which can increase the contact area with the palonosetron hydrochloride drug inside the containing barrel, thereby greatly improving the working speed.

[0015] The utility model is further configured as follows: a guide sleeve is slidably connected to the periphery of the guide rod, and the guide sleeve is fixedly connected to the inner side wall of the through hole.

[0016] By adopting the above technical solution and providing the guide sleeve, the friction between the guide rod and the through hole can be reduced, thereby greatly improving the service life of the guide rod.

[0017] The utility model is further configured as follows: a plurality of flow holes are opened on the top of the heat conducting plate, and the plurality of flow holes all penetrate the heat conducting plate and are equidistantly distributed around the circumference.

[0018] By adopting the above technical solution and setting the flow holes, the working efficiency of heating the containing barrel by the heat generated by the heating tube can be increased.

[0019] The utility model is further configured as follows: a heat-conducting fin used in conjunction with the heat-conducting plate is fixedly connected to the bottom of the containing barrel.

[0020] By adopting the above technical solution, heat-conducting fins are provided to increase the heat conduction rate, thereby greatly shortening the time required for heating the palonosetron hydrochloride drug inside the container.

[0021] In summary, the utility model has the following beneficial effects:

[0022] By setting up a crystallization mechanism, the containing barrel is placed on the top of the heat conduction plate, and then the palonosetron hydrochloride drug that needs to be crystallized is injected into the containing barrel, and then the heating tube is started. The heating tube will heat the containing barrel. When the heating work is completed, the cover on the liquid adding tube is unscrewed, and then cooling water is injected into the liquid injection chamber through the liquid adding tube. At this time, the cooling water inside the liquid injection chamber will exchange heat and cool down the palonosetron hydrochloride drug inside the containing barrel, so that the palonosetron hydrochloride drug will slowly cool down and crystallize.

[0023] By providing a stirring component, the heating rate of the palonosetron hydrochloride drug in the containing barrel can be increased, and the working efficiency of the palonosetron hydrochloride drug cooling and crystallization in the containing barrel can be improved.

[0024] Based on the above-mentioned improvements, the overall technical effect achieved by the present device is to prevent the cooling water from directly contacting the palonosetron hydrochloride drug in the containing barrel, thereby affecting the concentration of the drug and causing a decrease in product quality. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Figure 1 It is a schematic diagram of the overall structure of the utility model;

[0026] Figure 2 It is a structural schematic diagram of the crystallization mechanism of the utility model;

[0027] Figure 3 It is a structural schematic diagram of the stirring assembly and the screw stirring piece of the utility model;

[0028] Figure 4 It is a schematic diagram of the structure of the through hole, guide rod and guide sleeve of the utility model;

[0029] Figure 5 It is a structural schematic diagram of the flow hole and the heat conducting fin of the utility model.

[0030] In the figure, 1, bottom plate; 2, L-shaped plate; 3, containing barrel; 4, crystallization mechanism; 401, mounting groove; 402, heating tube; 403, heat transfer plate; 404, liquid injection chamber; 405, liquid adding tube; 406, liquid discharge tube; 407, sealing cover; 5, stirring assembly; 501, servo motor; 502, screw rod; 503, T-shaped plate; 504, stirring motor; 505, stirring shaft; 506, stirring rod; 6, through hole; 7, guide rod; 8, ribbon stirring blade; 9, guide sleeve; 10, flow hole; 11, heat transfer fin. DETAILED DESCRIPTION

[0031] The utility model is further described in detail below in conjunction with the accompanying drawings.

[0032] Example:

[0033] See also Figure 1-Figure 5The utility model provides a technical solution: a palonosetron hydrochloride crystallization device, comprising a bottom plate 1, an L-shaped plate 2 is fixedly connected to the top of the bottom plate 1, a containing barrel 3 is arranged on the top of the bottom plate 1, a crystallization mechanism 4 is arranged between the containing barrel 3 and the bottom plate 1, and a stirring component 5 is arranged between the L-shaped plate 2 and the containing barrel 3;

[0034] The crystallization mechanism 4 includes a mounting groove 401, a heating tube 402, a heat conducting plate 403, a liquid injection cavity 404, a liquid adding tube 405, a liquid draining tube 406 and a cover 407. The mounting groove 401 is opened at the top of the bottom plate 1, the heating tube 402 is arranged inside the mounting groove 401, the heat conducting plate 403 is bolted to the inside of the mounting groove 401 and is flush with the top of the bottom plate 1, the liquid injection cavity 404 is opened in the side wall of the receiving barrel 3, one end of the liquid adding tube 405 and the liquid draining tube 406 are fixedly connected to the side wall of the receiving barrel 3 and communicated with the liquid injection cavity 404, and the cover 407 is spirally connected to the other end of the liquid adding tube 405 and the liquid adding tube 405. By setting the mounting groove 401, the heating tube 402, the heat conducting plate 403, the liquid injection cavity 404, the liquid adding tube 405, the liquid draining tube 406, the cover 407 7 and stirring component 5. When in use, the containing barrel 3 is placed on the top of the heat conducting plate 403, and then the Palonosetron Hydrochloride drug that needs to be crystallized is injected into the containing barrel 3, and then the heating tube 402 is started. The heating tube 402 will heat the containing barrel 3. After the heating work is completed, the cover 407 on the liquid adding tube 405 is unscrewed, and then the cooling water is injected into the liquid injection cavity 404 through the liquid adding tube 405. At this time, the cooling water inside the liquid injection cavity 404 will exchange heat and cool down the Palonosetron Hydrochloride drug inside the containing barrel 3, so that the Palonosetron Hydrochloride drug is slowly cooled and crystallized. By setting the stirring component 5, the heating rate of the Palonosetron Hydrochloride drug in the containing barrel 3 can be improved, and at the same time, the working efficiency of the Palonosetron Hydrochloride drug in the containing barrel 3 is improved.

[0035] refer to Figure 3The stirring assembly 5 includes a servo motor 501, a screw rod 502, a T-shaped plate 503, a stirring motor 504, a stirring shaft 505 and a stirring rod 506. The servo motor 501 is bolted to the top of the L-shaped plate 2. One end of the screw rod 502 is connected to the top of the bottom plate 1 with a bearing. The other end of the screw rod 502 passes through the T-shaped plate 503 and is fixedly connected to the output end of the servo motor 501. The T-shaped plate 503 is spirally connected to the periphery of the screw rod 502. The stirring motor 504 is bolted to the top of the T-shaped plate 503. The stirring shaft 505 passes through the T-shaped plate 503 and is fixedly connected to the output end of the stirring motor 504. A plurality of stirring rods 506 are fixedly connected to the side wall of the stirring shaft 505 and are evenly distributed. By arranging the servo motor 501, the screw rod 502, T T-shaped plate 503, stirring motor 504, stirring shaft 505 and stirring rod 506, start servo motor 501 to drive screw 502 to rotate, because T-shaped plate 503 is spirally connected to screw 502, so T-shaped plate 503 will move up and down on screw 502, and at the same time, T-shaped plate 503 will drive stirring motor 504 and stirring shaft 505 to move up and down, so as to facilitate the separation of stirring shaft 505 and stirring rod 506 from containing barrel 3 to meet the use requirements in different situations, start stirring motor 504 to drive stirring shaft 505 and stirring rod 506 to rotate, so as to improve the heating rate of palonosetron hydrochloride drug in containing barrel 3, and at the same time improve the working efficiency of cooling and crystallizing of palonosetron hydrochloride drug in containing barrel 3.

[0036] refer to Figure 4 Two through holes 6 are provided on the top of the T-shaped plate 503 and are located on both sides of the screw rod 502. A guide rod 7 is slidably connected inside the through hole 6. The two ends of the guide rod 7 are fixedly connected to the top of the bottom plate 1 and the inner top of the L-shaped plate 2 respectively. By setting the through hole 6 and the guide rod 7, when the T-shaped plate 503 moves up and down on the screw rod 502, the through hole 6 on the T-shaped plate 503 will move along the trajectory of the guide rod 7, which can limit and guide the moving trajectory of the T-shaped plate 503, thereby greatly improving the stability of the T-shaped plate 503 during movement.

[0037] refer to Figure 3 Three ribbon stirring blades 8 are arranged on the periphery of the stirring shaft 505, and the three ribbon stirring blades 8 are respectively fixedly connected to one end of the stirring rod 506. By arranging the ribbon stirring blades 8, the ribbon stirring blades 8 can increase the contact area with the palonosetron hydrochloride drug inside the containing barrel 3, thereby greatly improving the working speed.

[0038] refer to Figure 4 The outer periphery of the guide rod 7 is slidably connected with a guide sleeve 9, and the guide sleeve 9 is fixedly connected to the inner wall of the through hole 6. By providing the guide sleeve 9, the friction between the guide rod 7 and the through hole 6 can be reduced, and the service life of the guide rod 7 can be greatly improved.

[0039] refer to Figure 5 A plurality of flow holes 10 are provided on the top of the heat conducting plate 403 , and the plurality of flow holes 10 all penetrate the heat conducting plate 403 and are evenly distributed around the circumference. By providing the flow holes 10 , the efficiency of heating the containing barrel 3 by using the heat generated by the heating tube 402 can be increased.

[0040] refer to Figure 5 The bottom of the storage barrel 3 is fixedly connected with a heat-conducting fin 11 used in conjunction with the heat-conducting plate 403. By providing the heat-conducting fin 11, the heat conduction rate is improved, and the time required for heating the palonosetron hydrochloride drug inside the storage barrel 3 is greatly shortened.

[0041] Brief description of the use process: When in use, place the holding barrel 3 on the top of the heat conducting plate 403, then inject the Palonosetron Hydrochloride drug that needs to be crystallized into the holding barrel 3, and then start the heating tube 402. The heating tube 402 will heat the holding barrel 3. Increasing the temperature will increase the solubility of the Palonosetron Hydrochloride drug inside the holding barrel 3, forming an oversaturated state. When the heating work is completed, unscrew the cover 407 on the liquid adding tube 405, and then inject cooling water into the liquid injection chamber 404 through the liquid adding tube 405. At this time, the cooling water inside the liquid injection chamber 404 will exchange heat and cool down the Palonosetron Hydrochloride drug inside the holding barrel 3, so that the Palonosetron Hydrochloride drug will slowly cool down. During warm crystallization, start the servo motor 501 to drive the screw 502 to rotate. Since the T-shaped plate 503 is spirally connected to the screw 502, the T-shaped plate 503 will move up and down on the screw 502. At the same time, the T-shaped plate 503 will drive the stirring motor 504 and the stirring shaft 505 to move up and down, so that the stirring shaft 505 and the stirring rod 506 can be separated from the containing barrel 3 to meet the usage requirements in different situations. Start the stirring motor 504 to drive the stirring shaft 505, the stirring rod 506 and the ribbon stirring blade 8 to rotate, thereby increasing the heating rate of the palonosetron hydrochloride drug in the containing barrel 3 and improving the working efficiency of cooling and crystallizing the palonosetron hydrochloride drug in the containing barrel 3.

[0042] This specific embodiment is merely an explanation of the present invention and is not a limitation of the present invention. After reading this specification, those skilled in the art may make non-creative modifications to the present embodiment as needed, but such modifications are protected by patent law as long as they are within the scope of the claims of the present invention.

Claims

1. A palonosetron hydrochloride crystallization device, comprising a bottom plate (1), characterized in that: An L-shaped plate (2) is fixedly connected to the top of the bottom plate (1), a containing barrel (3) is arranged on the top of the bottom plate (1), a crystallization mechanism (4) is arranged between the containing barrel (3) and the bottom plate (1), and a stirring assembly (5) is arranged between the L-shaped plate (2) and the containing barrel (3); The crystallization mechanism (4) comprises a mounting groove (401), a heating tube (402), a heat conducting plate (403), a liquid injection cavity (404), a liquid adding tube (405), a liquid draining tube (406) and a cover (407); the mounting groove (401) is opened at the top of the bottom plate (1); the heating tube (402) is arranged inside the mounting groove (401); the heat conducting plate (403) is bolted inside the mounting groove (401) and is flush with the top of the bottom plate (1); the liquid injection cavity (404) is opened in the side wall of the containing barrel (3); one end of the liquid adding tube (405) and the liquid draining tube (406) are fixedly connected to the side wall of the containing barrel (3) and communicated with the liquid injection cavity (404); and the cover (407) is spirally connected to the liquid adding tube (405) and the other end of the liquid adding tube (405).

2. A palonosetron hydrochloride crystallization device according to claim 1, characterized in that: The stirring assembly (5) comprises a servo motor (501), a screw rod (502), a T-shaped plate (503), a stirring motor (504), a stirring shaft (505) and a stirring rod (506); the servo motor (501) is bolted to the top of the L-shaped plate (2); one end of the screw rod (502) is connected to the top of the bottom plate (1) by a bearing; the other end of the screw rod (502) passes through the T-shaped plate (503) and is fixedly connected to the output end of the servo motor (501); the T-shaped plate (503) is spirally connected to the periphery of the screw rod (502); the stirring motor (504) is bolted to the top of the T-shaped plate (503); the stirring shaft (505) passes through the T-shaped plate (503) and is fixedly connected to the output end of the stirring motor (504); and a plurality of stirring rods (506) are fixedly connected to the side wall of the stirring shaft (505) and are evenly distributed.

3. A palonosetron hydrochloride crystallization device according to claim 2, characterized in that: The top of the T-shaped plate (503) is provided with two through holes (6) located on both sides of the screw rod (502); the interior of the through holes (6) is slidably connected with a guide rod (7); the two ends of the guide rod (7) are respectively fixedly connected to the top of the bottom plate (1) and the inner top of the L-shaped plate (2).

4. A palonosetron hydrochloride crystallization device according to claim 2, characterized in that: Three ribbon stirring blades (8) are arranged on the periphery of the stirring shaft (505), and the three ribbon stirring blades (8) are respectively fixedly connected to one end of the stirring rod (506).

5. A palonosetron hydrochloride crystallization device according to claim 3, characterized in that: A guide sleeve (9) is slidably connected to the periphery of the guide rod (7), and the guide sleeve (9) is fixedly connected to the inner side wall of the through hole (6).

6. A palonosetron hydrochloride crystallization device according to claim 1, characterized in that: A plurality of flow holes (10) are provided on the top of the heat conducting plate (403), and the plurality of flow holes (10) all penetrate the heat conducting plate (403) and are equidistantly distributed around the circumference.

7. A palonosetron hydrochloride crystallization device according to claim 1, characterized in that: The bottom of the containing barrel (3) is fixedly connected with a heat conducting fin (11) used in conjunction with the heat conducting plate (403).

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