Drug intermediate fractionation distillation equipment
By introducing a stirring and cleaning mechanism into the drug intermediate fractionation distillation equipment, the problem of heat unevenness and adhesion of the drug liquid during the distillation process is solved, and the distillation efficiency and thoroughness of the drug production are improved.
Patent Information
- Application Number
- CN202421111929.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-05-21
- Publication Date
- 2025-01-07
- Estimated Expiration
- 2034-05-21
AI Technical Summary
The existing drug intermediate fractionation distillation equipment has problems such as uneven heat, low distillation efficiency, and easy adhesion of the drug liquid on the inner wall of the distillation tower during the distillation process, resulting in incomplete and wasteful drug production.
A drug intermediate fractional distillation equipment including a distillation tower, agitating mechanism and a cleaning mechanism is designed. The rotating rod and spiral blade are driven by a stirring motor, and uniform heating is achieved using a heating plate and a heating rod, while wiping the cleaning mechanism. Clean the inner wall of the distillation tower with the rod to avoid adhesion of the liquid.
It improves the heating uniformity and distillation efficiency of the drug intermediate solution, reduces waste of drug solution, and ensures the thoroughness of drug production.
Smart Images
Figure CN222304800U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the field of pharmaceutical intermediates, and in particular to a pharmaceutical intermediate fractionation and distillation device. Background Art
[0002] Drug intermediates refer to intermediate products in the process of drug synthesis, which are usually obtained by multiple separations and purifications of various raw materials through a series of chemical reactions. They connect the API and the finished drug in the pharmaceutical process and are the key components of many drugs. Drug intermediates play an irreplaceable role in the pharmaceutical industry and have multiple functions, such as serving as the starting material or intermediate product for drug synthesis, and ultimately synthesizing drug molecules with specific pharmacological activity. In addition, the quality of drug intermediates directly affects the quality and stability of the drug, so there are usually high requirements for purity. In the process of separating and purifying drug intermediates, fractionation and distillation equipment is required.
[0003] In the existing drug intermediate fractionation and distillation equipment, the drug is heated unevenly during the drug distillation process, the distillation efficiency is low, and after the drug is distilled and separated, the drug liquid is prone to adhere to the inner wall of the distillation tower after condensation, resulting in incomplete drug discharge and waste. Therefore, we have made improvements to this and proposed a drug intermediate fractionation and distillation equipment. Utility Model Content
[0004] In view of the deficiencies in the prior art, the utility model provides a drug intermediate fractionation and distillation device, which solves the problems mentioned in the background technology.
[0005] In order to achieve the above-mentioned utility model purpose, the utility model provides the following technical solutions:
[0006] Pharmaceutical intermediate fractionation and distillation equipment is used to solve the above problems.
[0007] The specific application is as follows:
[0008] The distillation tower comprises a distillation tower, wherein a support leg is fixedly installed at the bottom of the distillation tower, a feed port is fixedly installed at the upper surface of the distillation tower, a stirring mechanism is arranged inside the distillation tower, a cleaning mechanism is arranged on one side of the stirring mechanism, a heating plate is fixedly installed on the inner wall of the distillation tower, a fixed pipe is fixedly installed at the bottom of the distillation tower, and a valve is fixedly installed outside the fixed pipe;
[0009] The stirring mechanism comprises a stirring motor, and the stirring motor is fixedly installed on the top of the distillation tower. A rotating rod is fixedly installed on the output end of the stirring motor, and a spiral blade is fixedly installed on the lower end surface of the rotating rod.
[0010] As a preferred technical solution of the present application, a driving gear is fixedly installed on the surface of the top of the rotating rod, a gear ring is fixedly installed on the inner wall of the distillation tower, and a driven gear is meshingly connected between the driving gear and the gear ring, a stirring rod is fixedly installed on the lower surface of the driven gear, and a plurality of heating rods are fixedly installed on the outer surface of the stirring rod.
[0011] As a preferred technical solution of the present application, a fixed plate is fixedly installed on the lower surface of the driving gear, and a fixed ring is fixedly installed on the lower surface of the gear ring, and the driven gear is slidably connected on the upper surfaces of the fixed plate and the fixed ring.
[0012] As a preferred technical solution of the present application, the cleaning mechanism includes a connecting rod, and one end of the connecting rod is fixedly connected to the rotating rod, the other end of the connecting rod is fixedly installed with a fixed frame, and the interior of the fixed frame is slidably connected with a wiping rod.
[0013] As a preferred technical solution of the present application, a spring is fixedly mounted on one side surface of the wiping rod, and the other end surface of the spring is connected to the inner wall of the fixed frame.
[0014] As a preferred technical solution of the present application, a condenser is fixedly installed on one side surface of the exterior of the distillation tower, and a steam pipe is fixedly installed on the upper surface of the condenser, and the other end of the steam pipe is connected to the top of the distillation tower, and a collecting box is fixedly installed on the outer surface of the distillation tower at the lower side of the condenser, and the condenser and the collecting box are connected.
[0015] Compared with the prior art, the utility model has the following beneficial effects:
[0016] In the scheme of this application:
[0017] 1. Through the use of the stirring mechanism and the heating plate, the drug intermediate solution to be separated and purified is added into the distillation tower, and the heating plate and the heating rod are started to work, and the drug intermediate solution is heated and distilled. At the same time, the stirring motor drives the rotating rod and the spiral blade to rotate to stir the drug intermediate solution. The rotating rod can also drive the driving gear to rotate, and cooperate with the gear ring to drive the driven gear to rotate. The driven gear drives the stirring rod and the heating rod to rotate, which can stir the drug intermediate solution, make it more evenly heated, and improve the efficiency of distillation.
[0018] 2. Through the use of the cleaning mechanism, during the stirring process, the rotating rod drives the connecting rod and the fixed frame to rotate, and the spring inside the fixed frame supports the wiping rod through elastic force, so that the wiping rod contacts the inner wall of the distillation tower. The wiping rod can be driven by the rotating rod to clean and scrape off the drugs produced after condensation on the inner wall of the distillation tower, thereby avoiding waste caused by incomplete drug discharge. BRIEF DESCRIPTION OF THE DRAWINGS
[0019] Figure 1 A three-dimensional structural schematic diagram of the pharmaceutical intermediate fractionation and distillation equipment provided in this application;
[0020] Figure 2 A schematic diagram of the three-dimensional structure of the internal structure of the drug intermediate fractionation and distillation equipment provided in this application;
[0021] Figure 3 A schematic diagram of the cross-sectional structure of the pharmaceutical intermediate fractionation and distillation equipment provided in the present application;
[0022] Figure 4 A schematic diagram of the structure of the driving gear and the driven gear of the drug intermediate fractionation and distillation equipment provided in this application;
[0023] Figure 5 This is a schematic structural diagram of the cross-section of the cleaning mechanism of the drug intermediate fractionation and distillation equipment provided in this application.
[0024] Indicated in the figure:
[0025] 1. Distillation tower; 2. Support legs; 3. Feed inlet; 4. Stirring mechanism; 401. Stirring motor; 402. Rotating rod; 403. Helical blade; 404. Driving gear; 405. Gear ring; 406. Driven gear; 407. Stirring rod; 408. Heating rod; 409. Fixed plate; 410. Fixed ring; 5. Heating plate; 6. Cleaning mechanism; 601. Connecting rod; 602. Fixed frame; 603. Wiping rod; 604. Spring; 7. Fixed pipe; 8. Valve; 9. Condenser; 10. Steam pipe; 11. Collecting box. DETAILED DESCRIPTION
[0026] To make the purpose, technical solution and advantages of the embodiment of the utility model clearer, the technical solution in the embodiment of the utility model will be described clearly and completely in conjunction with the accompanying drawings. Obviously, the described examples are part of the embodiments of the utility model, not all of the embodiments.
[0027] Therefore, the following detailed description of the embodiments of the present invention is not intended to limit the scope of the present invention to be protected, but merely represents some embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.
[0028] It should be noted that, in the absence of conflict, the embodiments of the present invention and the features and technical solutions in the embodiments may be combined with each other.
[0029] It should be noted that similar reference numerals and letters denote similar items in the following drawings, and therefore, once an item is defined in one drawing, further definition and explanation thereof is not required in subsequent drawings.
[0030] In the description of the present utility model, it should be noted that the orientation or position relationship indicated by the terms "upper" and "lower" is based on the orientation or position relationship shown in the drawings, or the orientation or position relationship in which the utility model product is usually placed when in use, or the orientation or position relationship commonly understood by those skilled in the art. Such terms are only for the convenience of describing the present utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present utility model. In addition, the terms "first" and "second" are only used to distinguish the description, and cannot be understood as indicating or implying relative importance.
[0031] In order to solve the technical problems in the background technology, the following pharmaceutical intermediate fractionation and distillation equipment is provided:
[0032] Combination Figure 1 - Figure 5 As shown, the utility model provides a drug intermediate fractionation and distillation device, comprising a distillation tower 1, a supporting leg 2 is fixedly installed at the bottom of the distillation tower 1, and a feed port 3 is fixedly installed on the upper surface of the distillation tower 1, a stirring mechanism 4 is arranged inside the distillation tower 1, and a cleaning mechanism 6 is arranged on one side of the stirring mechanism 4, a heating plate 5 is fixedly installed on the inner wall of the distillation tower 1, a fixed pipe 7 is fixedly installed at the bottom of the distillation tower 1, and a valve 8 is fixedly installed on the outside of the fixed pipe 7, the stirring mechanism 4 comprises a stirring motor 401, and the stirring motor 401 is fixedly installed on the top of the distillation tower 1, a rotating rod 402 is fixedly installed at the output end of the stirring motor 401, and a spiral blade 403 is fixedly installed on the lower end surface of the rotating rod 402.
[0033] In this embodiment: the drug intermediate solution to be separated and purified is added to the distillation tower 1, and the heating plate 5 is started to heat and distill the drug intermediate solution, and the stirring motor 401 is started at the same time. The stirring motor 401 will drive the rotating rod 402 at the output end and the spiral blade 403 on the surface to rotate to stir the drug intermediate solution. The drug produced after distillation can be discharged from the fixed tube 7 by opening the valve 8.
[0034] refer to Figure 1 - Figure 4 On the basis of the above embodiment, the stirring effect can be improved so that the drug intermediate solution is heated more evenly. This embodiment provides the following design:
[0035] As a preferred embodiment, a driving gear 404 is fixedly installed on the surface of the top of the rotating rod 402, a gear ring 405 is fixedly installed on the inner wall of the distillation tower 1, and a driven gear 406 is meshedly connected between the driving gear 404 and the gear ring 405, a stirring rod 407 is fixedly installed on the lower surface of the driven gear 406, and a plurality of heating rods 408 are fixedly installed on the outer surface of the stirring rod 407.
[0036] In this embodiment: when the rotating rod 402 rotates, it can drive the driving gear 404 to rotate. When the driving gear 404 rotates, it can drive the driven gear 406 to make a circular motion around the driving gear 404 and rotate on its own by cooperating with the outer gear ring 405. When the driven gear 406 rotates on its own, it will drive the stirring rod 407 on the lower surface and the heating rod 408 on the surface to rotate, and at the same time start the heating rod 408 to work, so that the drug intermediate solution can be heated during the stirring process, so that the drug intermediate solution is heated more evenly, thereby improving the distillation effect.
[0037] refer to Figure 2 - Figure 4 On the basis of the above embodiment, the driven gear 406 can be supported. The present embodiment provides the following design:
[0038] As a preferred embodiment, a fixing plate 409 is fixedly mounted on the lower surface of the driving gear 404 , and a fixing ring 410 is fixedly mounted on the lower surface of the gear ring 405 . The driven gear 406 is slidably connected on the upper surfaces of the fixing plate 409 and the fixing ring 410 .
[0039] In this embodiment, the driven gear 406 can be supported by the fixing plate 409 and the fixing ring 410 to prevent the driven gear 406 from falling from the middle of the driving gear 404 and the gear ring 405 .
[0040] refer to Figure 2 - Figure 5 On the basis of the above embodiment, the drug produced after the drug intermediate solution in the distillation tower 1 is condensed can be cleaned up. This embodiment provides the following design:
[0041] As a preferred embodiment, the cleaning mechanism 6 includes a connecting rod 601, and one end of the connecting rod 601 is fixedly connected to the rotating rod 402, and the other end of the connecting rod 601 is fixedly installed with a fixing frame 602, and the interior of the fixing frame 602 is slidably connected with a wiping rod 603.
[0042] In this embodiment: when the rotating rod 402 rotates, it can drive the connecting rod 601 to rotate, and the connecting rod 601 drives the fixed frame 602 to rotate, and the drugs condensed on the inner wall of the distillation tower 1 are cleaned by the wiping rod 603 inside the fixed frame 602 to avoid waste.
[0043] As a preferred embodiment, a spring 604 is fixedly mounted on one side surface of the wiping rod 603 , and the other end surface of the spring 604 is connected to the inner wall of the fixed frame 602 .
[0044] In this embodiment, the wiping rod 603 can be supported by the elastic force of the spring 604 so that the wiping rod 603 contacts the inner wall of the distillation tower 1, thereby facilitating the cleaning of the drugs produced by condensation.
[0045] refer to Figure 1 - Figure 4 On the basis of the above embodiment, the steam generated by distillation can be cleaned. This embodiment provides the following design:
[0046] As a preferred embodiment, a condenser 9 is fixedly installed on one side surface of the outside of the distillation tower 1, and a steam pipe 10 is fixedly installed on the upper surface of the condenser 9, and the other end of the steam pipe 10 is connected to the top of the distillation tower 1, and a collecting box 11 is fixedly installed on the outer surface of the distillation tower 1 at the lower side of the condenser 9, and the condenser 9 and the collecting box 11 are connected.
[0047] In this embodiment, the steam generated by distillation in the distillation tower 1 can be discharged into the condenser 9 through the steam pipe 10, and the hot steam is condensed by the condenser 9. The cold water generated after the treatment can be collected by the collection box 11 for subsequent treatment.
[0048] Specifically, the working principle of this solution is:
[0049] When in use, the drug intermediate solution to be separated and purified is added to the distillation tower 1, and the heating plate 5 is started to work, the drug intermediate solution is heated and distilled, and the stirring motor 401 is started to work. The stirring motor 401 will drive the rotating rod 402 at the output end and the spiral blade 403 on the surface to rotate. When the rotating rod 402 rotates, it can drive the driving gear 404 to rotate. When the driving gear 404 rotates, it can drive the driven gear 406 to make a circular motion around the driving gear 404 and rotate by cooperating with the outer gear ring 405. When the driven gear 406 rotates, it will drive the stirring rod 407 on the lower surface and the heating rod 408 on the surface to rotate. At the same time, the heating rod 408 is started to work, and the drug intermediate solution can be heated during the stirring process, so that the drug intermediate solution is heated more evenly, thereby improving the distillation effect.
[0050] When the rotating rod 402 rotates, it can drive the connecting rod 601 and the fixed frame 602 to rotate. The spring 604 inside the fixed frame 602 can support the wiping rod 603 through its own elastic force, so that the wiping rod 603 is in contact with the inner wall of the distillation tower 1. The drugs condensed on the inner wall of the distillation tower 1 are cleaned by the wiping rod 603 to avoid waste. The above is the working process of the whole device, and the contents not described in detail in this specification belong to the existing technology known to professional and technical personnel in this field.
[0051] The above embodiments are only used to illustrate the present invention and are not intended to limit the technical solutions described in the present invention. Although the present invention has been described in detail with reference to the above embodiments, the present invention is not limited to the above specific implementation methods. Therefore, any modification or equivalent replacement of the present invention; and all technical solutions and improvements thereof that do not depart from the spirit and scope of the present invention are included in the scope of the claims of the present invention.
Claims
1. A pharmaceutical intermediate fractionation and distillation device, comprising a distillation tower (1), characterized in that: The bottom of the distillation tower (1) is fixedly provided with a support leg (2), and the upper surface of the distillation tower (1) is fixedly provided with a feed port (3), the interior of the distillation tower (1) is provided with a stirring mechanism (4), and a cleaning mechanism (6) is provided on one side of the stirring mechanism (4), a heating plate (5) is fixedly provided on the inner wall of the distillation tower (1), a fixed pipe (7) is fixedly provided at the bottom of the distillation tower (1), and a valve (8) is fixedly provided on the outside of the fixed pipe (7); The stirring mechanism (4) comprises a stirring motor (401), and the stirring motor (401) is fixedly mounted on the top of the distillation tower (1), a rotating rod (402) is fixedly mounted on the output end of the stirring motor (401), and a spiral blade (403) is fixedly mounted on the lower end surface of the rotating rod (402).
2. A pharmaceutical intermediate fractionation and distillation device according to claim 1, characterized in that: A driving gear (404) is fixedly mounted on the surface of the top of the rotating rod (402), a gear ring (405) is fixedly mounted on the inner wall of the distillation tower (1), and a driven gear (406) is meshedly connected between the driving gear (404) and the gear ring (405), a stirring rod (407) is fixedly mounted on the lower surface of the driven gear (406), and a plurality of heating rods (408) are fixedly mounted on the outer surface of the stirring rod (407).
3. A pharmaceutical intermediate fractionation and distillation device according to claim 2, characterized in that: A fixing plate (409) is fixedly mounted on the lower surface of the driving gear (404), and a fixing ring (410) is fixedly mounted on the lower surface of the gear ring (405), and the driven gear (406) is slidably connected on the upper surfaces of the fixing plate (409) and the fixing ring (410).
4. A pharmaceutical intermediate fractionation and distillation device according to claim 1, characterized in that: The cleaning mechanism (6) comprises a connecting rod (601), one end of which is fixedly connected to the rotating rod (402), the other end of which is fixedly mounted with a fixing frame (602), and a wiping rod (603) is slidably connected inside the fixing frame (602).
5. A pharmaceutical intermediate fractionation and distillation device according to claim 4, characterized in that: A spring (604) is fixedly mounted on one side surface of the wiping rod (603), and the other end surface of the spring (604) is connected to the inner wall of the fixed frame (602).
6. A pharmaceutical intermediate fractionation and distillation device according to claim 1, characterized in that: A condenser (9) is fixedly mounted on one side surface of the exterior of the distillation tower (1), and a steam pipe (10) is fixedly mounted on the upper surface of the condenser (9), and the other end of the steam pipe (10) is connected to the top of the distillation tower (1). A collecting box (11) is fixedly mounted on the exterior surface of the distillation tower (1) below the condenser (9), and the condenser (9) and the collecting box (11) are connected.