Purifying device for producing crude heparin sodium

Abstract

The utility model belongs to the technical field of crude heparin sodium production, and particularly relates to a purification device for crude heparin sodium production, which comprises a purification tank and a support column, the support column is fixedly connected to the lower end of the outer side of the purification tank, the upper end of the purification tank is connected with a tank cover, and the left end of the inside of the tank cover is fixedly connected with a feed hopper. And a discharging pipe is fixedly connected to the middle position of the bottom end in the purification tank. According to the purification device for crude heparin sodium production, when crude heparin sodium is produced and purified, an output shaft of a motor is started to rotate to drive a rotating rod to rotate, stirring blades are driven to rotate together to stir liquid in a purification tank, after the liquid is stirred and mixed, an inserting rod is pressed to press the inserting rod into a circular groove, a tank cover is taken down from the upper end of the purification tank, and then the liquid is purified. And the rotating rod is driven to move upwards, so that the filter screen moves upwards along the inner side of the purification tank, impurities in liquid in the purification tank are filtered out and moved out of the purification tank together, and the purification of the crude heparin sodium is completed.

Description

Technical Field

[0001] The utility model relates to the technical field of crude heparin sodium production, in particular to a purification device for crude heparin sodium production. Background Art

[0002] Heparin sodium can interfere with many links of the blood coagulation process and has anticoagulant effects both in vivo and in vitro. Its mechanism of action is relatively complex. It mainly binds to antithrombin III (AT-III) and enhances the latter's inhibitory effect on activated coagulation factors II, IX, X, XI and XII. Its consequences involve preventing platelet aggregation and destruction, hindering the formation of coagulation activating enzymes, preventing prothrombin from turning into thrombin, inhibiting thrombin, and thus hindering fibrinogen from turning into fibrin, thereby exerting an anticoagulant effect.

[0003] When purifying crude sodium heparin, it is necessary to strictly control the raw materials and liquid metering to ensure the accuracy of the purification of crude sodium heparin. In addition, impurities that need to be insoluble will be produced during the purification of crude sodium heparin, and the impurities need to be cleaned. The existing purification device is not thorough during cleaning, which affects the use effect of the crude sodium heparin after purification in the later stage.

[0004] For example, a crude heparin sodium purification device disclosed in Chinese patent CN207904161U adopts a connecting pipe, a switch valve, a pipe cap and a metering controller to control the metering of the liquid added to the inner cavity, so as to achieve the effect of accurately purifying the crude heparin sodium, and ensure the tightness of the connecting pipe, which is convenient for cleaning the connecting pipe. Different liquids can be added through the connecting pipe, ensuring the diversity of use of the connecting pipe; by providing a slider and a filter screen, impurities generated during the purification of the crude heparin sodium can be cleaned, which can ensure that the impurities are cleaned thoroughly and avoid impurity residues.

[0005] However, the filter screen of the purification device cannot be taken out from the purification device, so it is inconvenient to clean the impurities on the filter screen.

[0006] For this reason, we urgently need to provide a crude heparin sodium production purification device that is easy to disassemble and assemble. Utility Model Content

[0007] The utility model aims to provide a purification device for crude heparin sodium production, so as to solve the problem that the filter screen of the purification device proposed in the above background technology cannot be taken out from the purification device, thereby making it inconvenient to clean the impurities on the filter screen.

[0008] To achieve the above-mentioned purpose, the utility model provides the following technical solutions: a purification device for crude sodium heparin production, comprising a purification tank and a support column, wherein the support column is fixedly connected to the lower end of the outer side of the purification tank, the upper end of the purification tank is connected to a tank cover, the inner left end of the tank cover is fixedly connected to a feed hopper, the middle position of the bottom end of the purification tank is fixedly connected to a discharge pipe, the inner and outer ends of the purification tank are connected to a purification mechanism, the purification mechanism comprises a disassembly unit and a feeding unit, the disassembly unit is arranged at the inner and outer ends of the purification tank, and the feeding unit is arranged above the right end of the purification tank.

[0009] The disassembly and assembly unit includes a motor, a rotating rod, a stirring blade, a limit plate, a filter, a fixed frame, a connecting plate, a spring and an insertion rod. The motor is fixedly connected to the upper middle position of the tank cover, the rotating rod is fixedly connected to the lower end of the output shaft of the motor, the stirring blade is fixedly connected to the outer side of the rotating rod, the limit plate is fixedly connected to the outer side of the rotating rod, the filter is connected to the outer side of the rotating rod, the fixed frame is fixedly connected to the left and right ends of the outer side of the tank cover, the connecting plate is fixedly connected to the left and right ends above the outer side of the purification tank, the spring is connected to the inner upper end of the connecting plate, and the insertion rod is fixedly connected to the front end of the spring.

[0010] A further improvement is that two limit plates are fixed at the lower end of the outer side of the rotating rod, a rotating hole is opened in the middle position of the filter screen, the outer side of the rotating rod is rotatably connected to the inner side of the rotating hole, the middle position of the upper and lower sides of the filter screen is slidably connected to the adjacent side of the two limit plates, and the outer edge of the filter screen is slidably connected to the inner side of the purification tank. Therefore, when the rotating rod moves upward, the filter screen can be driven to move upward along the inner side of the purification tank, and the impurities in the liquid in the purification tank are filtered and moved upward out of the purification tank.

[0011] A further improvement is that a circular groove is provided in the middle of the upper end of the connecting plate, the rear end of the spring is fixedly connected to the rear end of the inner side of the circular groove, and the outer side of the insertion rod is slidably connected to the inner side of the circular groove. Therefore, when the spring is elastic and drives the insertion rod to move, the insertion rod can be driven to slide along the inner side of the circular groove, which plays a role in limiting the movement of the insertion rod.

[0012] A further improvement is that a plug hole is provided in the middle of the front end of the fixing frame, the front end outer side of the plug rod is plugged into the inner side of the plug hole, and the upper end outer side of the connecting plate is slidably connected to the inner side of the fixing frame. Thus, after the tank cover is placed on the upper end of the purification tank and the fixing frames at the left and right ends thereof slide to the upper end outer side of the connecting plate, the plug rod is pushed forward by the spring rebound, so that the front end of the plug rod moves forward to the plug hole at the front end of the fixing frame, and the connecting plate is fixed to the inner side of the fixing frame, so that the tank cover is fixed to the upper end of the purification tank.

[0013] A further improvement is that the feeding unit includes a filling tube, a measuring bucket and a valve, the filling tube is fixedly connected to the upper right end of the interior of the purification tank, the measuring bucket is fixedly connected to the upper end of the filling tube, and the valve is fixedly connected to the inner upper end of the filling tube.

[0014] A further improvement is that the measuring bucket is made of transparent glass and has scale lines engraved on the outside of the measuring bucket, so that after the additive is added into the measuring bucket, the amount of the additive can be accurately measured according to the scale lines on the outside of the measuring bucket.

[0015] A further improvement is that a rubber pad is fixedly connected to the outer edge of the filter screen, so that when the filter screen moves upward along the inner side of the purification tank, the rubber pad at the outer edge of the filter screen contacts the inner side of the purification tank, so that impurities in the liquid inside the purification tank can be completely filtered by the filter screen.

[0016] In summary, the present application discloses a purification device for producing crude heparin sodium.

[0017] According to the technical solution, after the rod is pressed into the circular groove by the rear pressure, the tank cover can be removed from the upper end of the purification tank, driving the rotating rod to move upward, so that the filter moves upward along the inner side of the purification tank, and the impurities in the liquid in the purification tank are filtered and moved upward out of the purification tank, and then the impurities on the filter can be easily cleaned.

[0018] Furthermore, after the additive is added into the measuring bucket, the amount of the additive can be accurately measured according to the scale lines on the outside of the measuring bucket. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 It is a schematic diagram of the main structure of the utility model;

[0020] Figure 2 This is a schematic diagram of the internal structure of the purification tank of the utility model;

[0021] Figure 3 It is a schematic diagram of the structure below the tank cover of the utility model;

[0022] Figure 4 This is a schematic diagram of the internal structure of the connecting plate of the utility model;

[0023] Figure 5 It is a structural schematic diagram of the feeding unit of the utility model.

[0024] In the figure: 1. purification tank; 2. support column; 3. tank cover; 4. feed hopper; 5. discharge pipe; 601. motor; 602. rotating rod; 603. stirring blade; 604. limit plate; 605. filter screen; 606. fixing frame; 607. connecting plate; 608. spring; 609. plug rod; 701. stuffing tube; 702. measuring bucket; 703. valve. DETAILED DESCRIPTION

[0025] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0026] See also Figure 1-Figure 5 , the utility model provides a technical solution: Example

[0027] A purification device for crude sodium heparin production comprises a purification tank 1 and a support column 2, wherein the support column 2 is fixedly connected to the lower end of the outer side of the purification tank 1, the upper end of the purification tank 1 is connected to a tank cover 3, the inner left end of the tank cover 3 is fixedly connected to a feed hopper 4, a discharge pipe 5 is fixedly connected to the middle position of the bottom end of the purification tank 1, and the inner and outer ends of the purification tank 1 are connected to a purification mechanism, the purification mechanism comprises a disassembly unit and a feeding unit, the disassembly unit is arranged at the inner and outer ends of the purification tank 1, and the feeding unit is arranged above the right end of the purification tank 1.

[0028] The disassembly and assembly unit includes a motor 601, a rotating rod 602, a stirring blade 603, a limit plate 604, a filter screen 605, a fixed frame 606, a connecting plate 607, a spring 608 and an insertion rod 609. The motor 601 is fixedly connected to the middle position of the upper side of the tank cover 3, the rotating rod 602 is fixedly connected to the lower end of the output shaft of the motor 601, the stirring blade 603 is fixedly connected to the outer side of the rotating rod 602, the limit plate 604 is fixedly connected to the outer side of the rotating rod 602, the filter screen 605 is connected to the outer side of the rotating rod 602, and two limit plates 604 are fixed to the lower end of the outer side of the rotating rod 602. A rotating hole is opened in the middle position inside the filter screen 605, and the outer side of the rotating rod 602 is rotatably connected to the inner side of the rotating hole. The middle position of the upper and lower sides of the filter screen 605 is slidably connected to the adjacent side of the two limit plates 604, and the outer edge of the filter screen 605 is slidably connected to the inner side of the purification tank 1. Therefore, when the rotating rod 602 moves upward, the filter screen 605 can be driven to move upward along the inner side of the purification tank 1 , filtering impurities in the liquid in the purification tank 1 and moving them upward out of the purification tank 1 .

[0029] The fixing frame 606 is fixedly connected to the left and right ends of the outer side of the tank cover 3, the connecting plate 607 is fixedly connected to the left and right ends of the upper outer side of the purification tank 1, the spring 608 is connected to the inner upper end of the connecting plate 607, and the plug rod 609 is fixedly connected to the front end of the spring 608. A circular groove is provided in the middle of the inner upper end of the connecting plate 607, the rear end of the spring 608 is fixedly connected to the inner rear end of the circular groove, and the outer side of the plug rod 609 is slidably connected to the inner side of the circular groove. Therefore, when the spring 608 is elastically driven to move the plug rod 609, the plug rod 609 can be driven to slide along the inner side of the circular groove, which plays a role in limiting the movement of the plug rod 609.

[0030] A plug hole is provided in the middle of the front end of the fixed frame 606, the front end outer side of the plug rod 609 is plugged into the inner side of the plug hole, and the upper end outer side of the connecting plate 607 is slidably connected to the inner side of the fixed frame 606. Thus, after the tank cover 3 is placed on the upper end of the purification tank 1, and the fixed frames 606 at the left and right ends thereof slide to the upper end outer side of the connecting plate 607, the plug rod 609 is pushed forward by the spring 608 rebound, so that the front end of the plug rod 609 moves forward to the plug hole at the front end of the fixed frame 606, and the connecting plate 607 can be fixed to the inner side of the fixed frame 606, so that the tank cover 3 is fixed to the upper end of the purification tank 1. Example

[0031] On the basis of the first embodiment: the feeding unit includes a filling tube 701, a measuring bucket 702 and a valve 703, the filling tube 701 is fixedly connected to the upper right end of the interior of the purification tank 1, the measuring bucket 702 is fixedly connected to the upper end of the filling tube 701, and the valve 703 is fixedly connected to the upper end of the interior of the filling tube 701. The measuring bucket 702 is made of transparent glass, and the outer side of the measuring bucket 702 is engraved with scale lines. Therefore, after the additive is added to the measuring bucket 702, the dosage of the additive can be accurately measured according to the scale lines on the outer side of the measuring bucket 702. Example

[0032] On the basis of the first embodiment: a rubber pad is fixedly connected to the outer edge of the filter screen 605. Therefore, when the filter screen 605 moves upward along the inner side of the purification tank 1, the rubber pad at the outer edge of the filter screen 605 contacts the inner side of the purification tank 1, so that the impurities in the liquid inside the purification tank 1 can be completely filtered by the filter screen 605.

[0033] Working principle: When the crude heparin sodium is produced and purified, the motor 601 is started and its output shaft rotates to drive the rotating rod 602 to rotate, and the stirring blade 603 is driven to rotate together to stir the liquid in the purification tank 1. After the liquid is stirred and mixed, the rod 609 is pressed back to press it into the circular groove, and then the tank cover 3 is removed from the upper end of the purification tank 1, driving the rotating rod 602 to move up, so that the filter screen 605 moves up along the inner side of the purification tank 1, and the impurities in the liquid in the purification tank 1 are filtered and moved up out of the purification tank 1, thereby completing the purification of the crude heparin sodium.

[0034] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device. In the absence of further restrictions, the elements defined by the statement "comprise a ..." do not exclude the presence of other identical elements in the process, method, article or device including the elements.

Claims

1. A purification device for producing crude heparin sodium, comprising a purification tank (1) and a support column (2), wherein the support column (2) is fixedly connected to the lower end of the outer side of the purification tank (1), characterized in that: The upper end of the purification tank (1) is connected to a tank cover (3), the inner left end of the tank cover (3) is fixedly connected to a feed hopper (4), the middle position of the bottom end of the purification tank (1) is fixedly connected to a discharge pipe (5), the inner and outer ends of the purification tank (1) are connected to a purification mechanism, the purification mechanism comprises a disassembly unit and a feeding unit, the disassembly unit is arranged at the inner and outer ends of the purification tank (1), and the feeding unit is arranged above the right end of the purification tank (1); The disassembly and assembly unit comprises a motor (601), a rotating rod (602), a stirring blade (603), a limiting plate (604), a filter screen (605), a fixing frame (606), a connecting plate (607), a spring (608) and an insertion rod (609); the motor (601) is fixedly connected to the middle position of the upper side of the tank cover (3); the rotating rod (602) is fixedly connected to the lower end of the output shaft of the motor (601); and the stirring blade (603) is fixedly connected to the rotating rod (602). The limiting plate (604) is fixedly connected to the outside of the rotating rod (602), the filter screen (605) is connected to the outside of the rotating rod (602), the fixing frame (606) is fixedly connected to the left and right ends of the outside of the tank cover (3), the connecting plate (607) is fixedly connected to the left and right ends of the upper outside of the purification tank (1), the spring (608) is connected to the inner upper end of the connecting plate (607), and the insert rod (609) is fixedly connected to the front end of the spring (608).

2. A purification device for producing crude heparin sodium according to claim 1, characterized in that: Two limit plates (604) are fixed to the lower end of the outer side of the rotating rod (602), a rotating hole is opened in the middle position inside the filter (605), the outer side of the rotating rod (602) is rotatably connected to the inner side of the rotating hole, the middle position of the upper and lower sides of the filter (605) is slidably connected to the adjacent side of the two limit plates (604), and the outer edge of the filter (605) is slidably connected to the inner side of the purification tank (1).

3. A purification device for producing crude heparin sodium according to claim 1, characterized in that: A circular groove is provided in the middle of the upper end of the connecting plate (607), the rear end of the spring (608) is fixedly connected to the inner rear end of the circular groove, and the outer side of the insertion rod (609) is slidably connected to the inner side of the circular groove.

4. A purification device for producing crude heparin sodium according to claim 1, characterized in that: A plug hole is provided in the middle of the front end of the fixed frame (606); the front end outer side of the plug rod (609) is plugged into the inner side of the plug hole; the upper end outer side of the connecting plate (607) is slidably connected to the inner side of the fixed frame (606).

5. The purification device for producing crude heparin sodium according to claim 1, characterized in that: The feeding unit comprises a filling tube (701), a measuring bucket (702) and a valve (703); the filling tube (701) is fixedly connected to the upper right end of the interior of the purification tank (1); the measuring bucket (702) is fixedly connected to the upper end of the filling tube (701); and the valve (703) is fixedly connected to the upper end of the interior of the filling tube (701).

6. A purification device for producing crude heparin sodium according to claim 5, characterized in that: The measuring bucket (702) is made of transparent glass, and scale lines are engraved on the outer side of the measuring bucket (702).

7. A purification device for producing crude heparin sodium according to claim 1, characterized in that: A rubber pad is fixedly connected to the outer edge of the filter screen (605).

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