Novel cell transfusion bag

Abstract

The utility model discloses a novel cell transfusion bag which comprises a cell bag and a saline bag, the upper end and the lower end of the cell bag are both sealed edges, and the novel cell transfusion bag further comprises a saline bag. A separating film is arranged in the cell bag and divides the cell bag into a cell accommodating cavity and a placing cavity, and the saline bag is arranged in the placing cavity; the upper end of the cell bag is provided with a first butterfly opening and an input pipe which are communicated with the cell accommodating cavity, the lower end of the cell bag is provided with a second butterfly opening communicated with the cell accommodating cavity, a filter is arranged at the second butterfly opening in the cell bag, and the filter is used for filtering up and down; the saline bag is connected with the separation membrane, a release opening is formed in the joint of the saline bag and the separation membrane, an easy-to-fold part is arranged on the release opening for blocking, and after the easy-to-fold part is folded and damaged, the saline bag is communicated with the cell containing cavity. The cell bag can be flushed at the end of cell transfusion, cells can be flushed cleanly, pollution probability caused by frequent manual operation can be avoided, and the cell bag flushing device is safe, sanitary and good in using effect.

Description

Technical Field

[0001] The utility model relates to the technical field of cell reinfusion equipment, in particular to a novel cell reinfusion bag. Background Art

[0002] In recent years, based on the rapid development of the cell industry, especially stem cells and immune cells, cell therapy has begun to be applied to clinical experimental research on a variety of diseases such as immune system diseases, diabetes and cancer, and has achieved exciting preliminary research results, showing broad prospects for clinical application. Cell therapy is the use of bioengineering methods to obtain certain cells with specific functions in the body. After in vitro amplification, special culture and other treatments, these cells have therapeutic effects such as enhancing immunity, killing pathogens and tumor cells, promoting tissue and organ regeneration and body recovery, thereby achieving the purpose of treating diseases. With the development of biological technology, cell therapy is developing rapidly and being increasingly accepted by people around the world. The essence of cell therapy is the acquisition and storage of living cells. The transfusion bag is a bag for storing cells, which is used to transfuse cells back into the body.

[0003] During cell therapy, cells need to be kept in the same container from collection to final transfusion to avoid contamination. The biological sample may need to be tested before transfusion, and the remaining cells in the cell bag need to be flushed at the end of transfusion. However, existing transfusion bags cannot meet the needs of flushing the remaining cells in the cell bag at the end, and there are also problems such as single connection port, difficult sampling and testing, and poor sterility assurance. Utility Model Content

[0004] In view of the above-mentioned defects in the prior art, the purpose of the present invention is to provide a new type of cell reinfusion bag. By changing the structure of the cell reinfusion bag, adding a separation membrane and a variety of docking ports, the problems of the existing reinfusion bags are that they cannot meet the requirements of the final flushing of the residual cells in the cell bag, the single connection port, sampling and testing, and sterility assurance.

[0005] In order to achieve the above purpose, the utility model adopts the following technical solutions:

[0006] A novel cell reinfusion bag comprises a cell bag, the upper and lower ends of which are both sealed, and a saline bag; a separation membrane is arranged inside the cell bag, dividing the cell bag into a cell containing cavity and a placement cavity, and the saline bag is arranged in the placement cavity; a butterfly port 1 and an input tube are arranged at the upper end of the cell bag, a butterfly port 2 communicating with the cell containing cavity is arranged at the lower end of the cell bag, a filter is arranged at the butterfly port 2 in the cell bag, and the filter filters up and down; the saline bag is connected to the separation membrane, and a release port is arranged at the connection, and an easy-to-break piece is arranged on the release port for blocking, and after the easy-to-break piece is broken, the saline bag is connected to the cell containing cavity.

[0007] Furthermore, the two ends of the separation membrane are divided into a release end and a fixed end, the fixed end is connected to the top of the filter side wall, the saline bag is connected to the separation membrane at the release end, and the release end is higher than the fixed end.

[0008] Furthermore, the volume of the saline bag is half of that of the cell bag.

[0009] Furthermore, the input tube is divided into a syringe port, a sterile docking port and a rubber port through a pivot port.

[0010] Furthermore, a bag hanging opening is provided at the upper end of the cell bag.

[0011] Furthermore, the material of the easy-to-break component is one of polycarbonate, polyethylene, polystyrene and polypropylene, and the easy-to-break component is easy to break by providing a sharp depression.

[0012] Furthermore, a label area is arranged outside the cell bag.

[0013] Compared with the prior art, the utility model has the following beneficial effects:

[0014] The utility model has a simple and reasonable structure and is easy to use. It can avoid the probability of contamination caused by frequent manual operations during cell collection, transportation and detection. It can also rinse the cell bag at the end of cell reinfusion, which can not only rinse the cells clean but also avoid the probability of contamination caused by frequent manual operations. It is safe and hygienic and has a good use effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 The utility model is a structural schematic diagram of a novel cell reinfusion bag.

[0016] In the figure: 1. Butterfly mouth 1; 2. Bag hanging mouth; 3. Cell bag; 4. Easy folding mouth; 5. Saline bag; 6. Label area; 7. Filter; 8. Butterfly mouth 2; 9. Input tube; 10. Pivot port; 11. Syringe port; 12. Sterile docking port; 13. Rubber port; 14. Separation membrane. DETAILED DESCRIPTION

[0017] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0018] See also Figure 1The utility model provides a novel cell reinfusion bag, comprising a cell bag 3 and a saline bag 5. The upper and lower ends of the cell bag 3 are both sealed. A separation membrane 14 is arranged inside the cell bag 3 to divide the cell bag 3 into a cell holding cavity and a placement cavity. The saline bag 5 is arranged in the placement cavity. The upper end of the cell bag 3 is provided with a butterfly mouth 1 and an input tube 9 connected to the cell holding cavity. The lower end of the cell bag 3 is provided with a butterfly mouth 2 8 connected to the cell holding cavity. A filter 7 is arranged at the butterfly mouth 2 8 in the cell bag 3. The filter 7 filters up and down. The saline bag 5 is connected to the separation membrane 14, and a release port is arranged at the connection. The release port is provided with an easily foldable part 4 for blocking. After the easily foldable part 4 is folded and damaged, the saline bag 5 is connected to the cell holding cavity.

[0019] Specifically, the cell bag 3 and the saline bag 5 are both sealed bags.

[0020] Specifically, the butterfly mouth 1 and the butterfly mouth 2 8 are used in conjunction with a butterfly plug, the butterfly mouth 1 is used to connect other medical devices, and the butterfly mouth 2 8 is used to insert an infusion tube.

[0021] Specifically, the volume of the saline bag 5 is half of that of the cell bag 3 .

[0022] Specifically, the filter 7 is used to filter aggregated cell clusters.

[0023] Specifically, the input tube 9 is divided into a syringe port 11, a sterile docking port 12, and a rubber port 13 through a pivot port 10 to meet the requirements of different connection methods.

[0024] Specifically, a bag hanging opening 2 is provided at the upper end of the cell bag 3 , and the bag hanging opening 2 is located on the sealed edge of the cell bag 3 , and is used to fix and hang the cell bag 3 to improve the convenience of use.

[0025] Specifically, the two ends of the separation membrane 14 are divided into a release end and a fixed end. The fixed end is connected to the top of the side wall of the filter 7. The saline bag 5 is connected to the separation membrane 14 at the release end. The release end is higher than the fixed end, which is convenient for emptying the cell holding cavity and flushing the cells that finally remain in the cell holding cavity. The saline bag 5 is connected to the release port at the connection by lightly folding the foldable part 4, and the saline in the saline bag is introduced into the cell holding cavity for flushing and re-infusion, thereby reducing cell loss and no longer requiring manual flushing, thereby meeting the requirements of sterility.

[0026] Specifically, the material of the easy-to-break component 4 is one of polycarbonate, polyethylene, polystyrene and polypropylene, and the easy-to-break component 4 is easy to break by providing a sharp depression.

[0027] Specifically, a label area 6 is provided on the outside of the cell bag 3 to facilitate recording of usage information.

[0028] When using, follow the steps below:

[0029] S1. Place the new cell transfusion bag in a biosafety cabinet, open the screw cap of the syringe port 11, connect the outer tube of the syringe, pour the collected cell suspension into the cell holding cavity through the outer tube of the syringe, and then heat-seal the catheter of the syringe port 11 with a heat sealer, and attach a cell coding label to the label area 6.

[0030] S2. Put the whole cell transfusion bag into the vaccine box and send it out for use in clinical research in the hospital.

[0031] S3. When in use, insert the infusion set from the butterfly port 8 for reinfusion. After the reinfusion of the cell suspension in the cell accommodation cavity is completed, gently fold the easy-folding port 4 to connect the release end of the separation membrane 14 with the release port of the connection between the saline bag 5, inject the physiological saline in the saline bag 5 into the cell accommodation cavity, flush the remaining cells, and continue to reinfuse to reduce cell loss.

[0032] It should be noted that the filter 7, the syringe port 11, the sterile docking port 12, and the rubber port 13 in the present invention are common medical devices, and those skilled in the art are clear about their structures and usage methods.

[0033] All components and connection methods of components not discussed in this application belong to the known technologies in this technical field and can be directly applied without further explanation.

[0034] In the present invention, the term "plurality" means two or more than two, unless otherwise clearly defined. The terms "install", "connect", "connect", "fix" and the like should be understood in a broad sense. For example, "connect" can be a fixed connection, a detachable connection, or an integral connection; "connected" can be a direct connection or an indirect connection through an intermediate medium. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to the specific circumstances.

[0035] In the description of the present invention, it is necessary to understand that the directions or positional relationships indicated by terms such as "up", "down", "left", "right", "front" and "back" are based on the directions or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or unit referred to must have a specific direction, be constructed and operated in a specific orientation, and therefore, cannot be understood as a limitation on the present invention.

[0036] In the description of this specification, the description of the terms "one embodiment", "some embodiments", "specific embodiments", etc. means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the utility model. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner.

[0037] The above description is only the preferred embodiment of the utility model, and is not intended to limit the utility model. For those skilled in the art, the utility model can have various modifications and changes. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the utility model shall be included in the protection scope of the utility model.

Claims

1. A novel cell transfusion bag, comprising a cell bag, wherein the upper and lower ends of the cell bag are sealed, characterized in that: Also included are saline bags; A separation membrane is arranged in the cell bag, dividing the cell bag into a cell holding cavity and a placement cavity, and the saline bag is arranged in the placement cavity; The cell bag is provided with a butterfly port 1 and an input tube connected to the cell accommodation cavity at the upper end, and a butterfly port 2 connected to the cell accommodation cavity at the lower end. A filter is provided at the butterfly port 2 in the cell bag, and the filter filters up and down; The saline bag is connected to the separation membrane, and a release port is arranged at the connection. The release port is provided with an easy-to-break piece for sealing. After the easy-to-break piece is broken, the saline bag is connected to the cell containing cavity.

2. A novel cell reinfusion bag according to claim 1, characterized in that: The two ends of the separation membrane are divided into a release end and a fixed end. The fixed end is connected to the top of the filter side wall. The saline bag is connected to the separation membrane at the release end, and the release end is higher than the fixed end.

3. A novel cell reinfusion bag according to claim 1, characterized in that: The volume of the saline bag is half of that of the cell bag.

4. A novel cell reinfusion bag according to claim 1, characterized in that: The input tube is divided into a syringe port, a sterile docking port and a rubber port through a pivot port.

5. A novel cell reinfusion bag according to claim 1, characterized in that: The upper end of the cell bag is provided with a bag hanging opening.

6. A novel cell reinfusion bag according to claim 1, characterized in that: The material of the easy-to-break component is one of polycarbonate, polyethylene, polystyrene and polypropylene, and the easy-to-break component is easy to break by providing a sharp depression.

7. A novel cell reinfusion bag according to claim 1, characterized in that: A label area is arranged outside the cell bag.

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