Analyzing device of cyanoacetic acid high performance liquid chromatography

Abstract

The utility model discloses an analysis device for cyanoacetic acid high performance liquid chromatography, which belongs to the technical field of liquid chromatographs, and is characterized by comprising a liquid chromatograph body, a loading box is arranged at the top of the liquid chromatograph body, a support plate is fixedly connected onto the inner wall of the loading box, and the support plate is fixedly connected with the liquid chromatograph body. Three placing grooves are formed in the top surface of the supporting plate at equal intervals, reagent bottles are placed in the placing grooves, a protection mechanism used for limiting the reagent bottles is arranged on the top surface of the supporting plate, and a liquid collecting machine is arranged on the side wall of the carrying box. The protection mechanism can clamp and limit the reagent bottle placed in the placement groove, the reagent bottle is prevented from toppling over in the placement groove to cause outflow of a reagent in the reagent bottle, the liquid collection mechanism can collect the reagent leaked and flowing out from the interior of the reagent bottle, and meanwhile, the collected reagent can be conveniently cleaned.

Description

Technical Field

[0001] The utility model relates to the technical field of liquid chromatographs, in particular to an analysis device for cyanoacetic acid high performance liquid chromatography. Background Art

[0002] Cyanoacetic acid is an organic synthesis intermediate, mainly used for the synthesis of cyanoacetates, and also used for the production of cyanoacrylate and butyral (medical adhesive), vitamin B6, caffeine, barbiturate, etc. In the process of increasing the cyanoacetic acid content, in order to better analyze the decomposition products, side reaction products, components and decomposition amounts of each impurity produced in each step of the reaction, it is necessary to use a liquid chromatograph to analyze the parameters of cyanoacetic acid.

[0003] Liquid chromatographs are often used for pharmaceutical liquid analysis, so they are often used in designated working environments, especially in environments with humid ground. If no supporting structure is set up, the bottom is easily corroded by the pharmaceutical liquid, which will reduce the service life of the liquid chromatograph.

[0004] The Chinese utility model patent with the current announcement number CN219639799U discloses a liquid chromatograph for metronidazole production. The liquid chromatograph for metronidazole production is conveniently supported by providing a support plate and a first movable groove.

[0005] In view of the above problems, the existing patents provide solutions, but no limit protection is provided for the reagent bottles. When the liquid chromatograph or the reagent bottle is accidentally touched, or when the liquid chromatograph is moved or transported, the reagent bottle is prone to tipping over, causing the liquid inside the reagent bottle to flow out, causing damage to the liquid chromatograph.

[0006] For this reason, a kind of analytical device of cyanoacetic acid high performance liquid chromatography is proposed. Utility Model Content

[0007] 1. Technical issues to be solved

[0008] The utility model provides an analysis device for cyanoacetic acid high performance liquid chromatography, aiming to solve the problem that the existing liquid chromatograph has no limit protection for a reagent bottle, when the liquid chromatograph or the reagent bottle is accidentally touched, or when the liquid chromatograph is moved and transported, the reagent bottle is prone to tipping over, causing the liquid inside the reagent bottle to flow out, thus causing damage to the liquid chromatograph.

[0009] Technical Solution

[0010] The utility model is implemented as follows: an analysis device for cyanoacetic acid high performance liquid chromatography comprises a liquid chromatograph body, a material carrier box is arranged on the top of the liquid chromatograph body, a support plate is fixedly connected to the inner wall of the material carrier box, three placement grooves are arranged at equal intervals on the top surface of the support plate, reagent bottles are placed inside the placement grooves, a protective mechanism for limiting the position of the reagent bottles is arranged on the top surface of the support plate, and a liquid collecting mechanism is arranged on the side wall of the material carrier box;

[0011] The protective mechanism includes a fixed plate, a fixed column, a hinged column, a limit cover, a locking sleeve, a spring and a limit ring. The three fixed plates are fixedly connected to the top surface of the support plate, the fixed column is fixedly connected to the side wall of the support plate, the hinged column is hinged to the end of the fixed column away from the fixed plate, the limit cover is fixedly connected to the end of the hinged column away from the fixed column and is snap-fitted with the top of the reagent bottle, the locking sleeve is sleeved on the side walls of the fixed column and the hinged column, the spring is sleeved on the side wall of the fixed column and its two ends are respectively fixedly connected to the locking sleeve and the fixed plate, and the limit ring is fixedly connected to the side wall of the hinged column.

[0012] In order to collect the reagents leaked from the reagent bottles and to facilitate the cleaning of the collected reagents, a preferred analytical device for a cyanoacetic acid high performance liquid chromatography method of the utility model comprises a liquid collecting mechanism including a liquid collecting port, a collecting frame and a glass container, wherein the liquid collecting port is provided on the bottom surface of the placement groove and the side wall is inclined, the collecting frame is movably provided on the side wall of the cargo box, and the three glass containers are fixedly connected to the side wall of the collecting frame and are located below the liquid collecting port.

[0013] In order to achieve the effect of supporting and protecting the reagent bottles placed in the placement groove, as a preferred analytical device for the cyanoacetic acid high performance liquid chromatography method of the utility model, a plurality of support frames are fixedly connected to the top surface of the support plate, two of the support frames form a group, and protective rings are fixedly connected to the side walls of the two support frames, and the side walls of the protective rings are in contact with the reagent bottles.

[0014] In order to achieve the effect of anti-collision and anti-slip protection when the reagent bottle contacts the placement groove, as a preferred analytical device for cyanoacetic acid high performance liquid chromatography of the utility model, rubber pads are bonded to the side walls and bottom surface of the placement groove, and the side walls of the rubber pads are in contact with the reagent bottle.

[0015] In order to achieve the effect of heating the reagent bottle at low temperature, as a preferred analytical device for cyanoacetic acid high performance liquid chromatography of the utility model, a heating ring is embedded on the bottom surface of the placement groove, and the top surface of the heating ring is in contact with the reagent bottle.

[0016] In order to protect the reagent collected inside the glass container and prevent the liquid inside the glass container from leaking when the collection frame is taken out, as a preferred analysis device for cyanoacetic acid high performance liquid chromatography of the utility model, the top of the glass container is threadedly connected with a top cover, and a through hole is opened in the middle of the top cover.

[0017] In order to achieve the effect of guiding the reagent falling from the liquid collection port and preventing the reagent from remaining on the bottom surface of the support plate, as a preferred analysis device for the cyanoacetic acid high performance liquid chromatography method of the utility model, three guide rings are fixedly connected to the bottom surface of the support plate, and the guide rings are located below the liquid collection port.

[0018] In order to facilitate the placement of the reagent bottle in the placement groove, as a preferred analytical device for cyanoacetic acid high performance liquid chromatography of the utility model, the side wall at the top of the placement groove is inclined. Beneficial Effects

[0019] Compared with the prior art, the beneficial effects of the utility model are:

[0020] The utility model can clamp and limit the reagent bottle placed in the placement groove by arranging a protection mechanism, so as to prevent the reagent bottle from tipping over in the placement groove and causing the reagent in the reagent bottle to flow out, thereby effectively solving the problem in the prior art that the reagent bottle is not limited and protected, and the reagent bottle is prone to tipping over when the liquid chromatograph or the reagent bottle is accidentally touched, or when the liquid chromatograph is moved and transported, causing the liquid in the reagent bottle to flow out.

[0021] 2. The utility model can collect and process the reagents leaking out from the inside of the reagent bottle by setting up a liquid collector, and can also facilitate the cleaning of the collected reagents, thereby effectively solving the problem in the prior art that the liquid inside the reagent bottle flows out and causes damage to the liquid chromatograph. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 It is the overall structure diagram of the utility model;

[0023] Figure 2 It is a three-dimensional diagram of the utility model's cargo box, support plate, placement slot, reagent bottle, support frame and protective ring;

[0024] Figure 3 It is a front view of the partial structure of the utility model;

[0025] Figure 4 For this utility model Figure 3 The three-dimensional cross-section view at AA in the middle;

[0026] Figure 5It is a three-dimensional schematic diagram of the local structure of the utility model;

[0027] Figure 6 For this utility model Figure 5 Enlarged view of point A in the middle.

[0028] Description of the numbers in the figure:

[0029] 1. Liquid chromatograph body; 21. Loading box; 22. Support plate; 23. Placement slot; 24. Reagent bottle; 3. Protection mechanism; 4. Liquid collecting mechanism; 31. Fixed plate; 32. Fixed column; 33. Articulated column; 34. Limit cover; 35. Lock sleeve; 36. Spring; 37. Limit ring; 41. Liquid collection port; 42. Collection frame; 43. Glass container; 51. Support frame; 52. Protection ring; 61. Rubber pad; 71. Heating ring; 81. Top cover; 82. Through hole; 9. Guide ring. DETAILED DESCRIPTION

[0030] In order to make the purpose, technical solution and advantages of the utility model more clear, the utility model is further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the utility model and are not used to limit the utility model.

[0031] See also Figure 1-Figure 6 The utility model provides a technical solution: an analysis device for cyanoacetic acid high performance liquid chromatography, comprising a liquid chromatograph body 1, a material carrying box 21 is arranged on the top of the liquid chromatograph body 1, a support plate 22 is fixedly connected to the inner wall of the material carrying box 21, three placement grooves 23 are arranged at equal intervals on the top surface of the support plate 22, a reagent bottle 24 is placed inside the placement groove 23, a protective mechanism 3 for limiting the position of the reagent bottle 24 is arranged on the top surface of the support plate 22, and a liquid collecting mechanism 4 is arranged on the side wall of the material carrying box 21;

[0032] The protective mechanism 3 includes a fixed plate 31, a fixed column 32, a hinged column 33, a limit cover 34, a locking sleeve 35, a spring 36 and a limit ring 37. The three fixed plates 31 are fixedly connected to the top surface of the support plate 22, the fixed column 32 is fixedly connected to the side wall of the support plate 22, the hinged column 33 is hinged to the end of the fixed column 32 away from the fixed plate 31, the limit cover 34 is fixedly connected to the end of the hinged column 33 away from the fixed column 32 and is snap-fitted with the top of the reagent bottle 24, the locking sleeve 35 is sleeved on the side walls of the fixed column 32 and the hinged column 33, the spring 36 is sleeved on the side wall of the fixed column 32 and its two ends are respectively fixedly connected to the locking sleeve 35 and the fixed plate 31, and the limit ring 37 is fixedly connected to the side wall of the hinged column 33.

[0033] In this embodiment: by setting the liquid chromatograph body 1, the cargo box 21, the support plate 22, the placement slot 23, the reagent bottle 24, the protection mechanism 3 and the liquid collecting mechanism 4, when in use, the reagent bottle 24 to be tested is placed in the placement slot 23, the protection mechanism 3 can clamp and limit the reagent bottle 24 placed in the placement slot 23 to prevent the reagent bottle 24 from tipping over inside the placement slot 23 and causing the reagent inside the reagent bottle 24 to flow out, the liquid collecting mechanism 4 can collect and process the reagent leaked from the inside of the reagent bottle 24, and at the same time can facilitate the cleaning of the collected reagent; by setting the fixing plate 31, the fixing column 32, the hinged column 33, the limiting cover 34, the locking sleeve 35, the spring 36 and the limiting ring 37, first push the locking sleeve 35 to squeeze the spring 36, at this time the spring 36 The locking sleeve 35 is retracted and moves away from the hinged part of the hinged column 33 and the fixed column 32. At this time, the hinged column 33 is pushed to drive the limiting cover 34 to move upward, and then the reagent bottle 24 is placed in the placement groove 23, and the hinged column 33 and the fixed column 32 are pulled to be horizontal. At this time, the limiting cover 34 is sleeved on the reagent bottle 24, and the locking sleeve 35 is released from squeezing the spring 36. At this time, the spring 36 is reset and pushes the locking sleeve 35 to move on the fixed column 32 and the hinged column 33. The limiting ring 37 limits the movement range of the locking sleeve 35. The locking sleeve 35 is located at the connecting part of the hinged column 33 and the fixed column 32. At this time, the hinged column 33 and the fixed column 32 cannot move. In this way, the reagent bottle 24 placed in the placement groove 23 can be clamped and limited to prevent the reagent bottle 24 from tipping over inside the placement groove 23.

[0034] As a technical optimization solution of the utility model, the liquid collection mechanism 4 includes a liquid collection port 41, a collection frame 42 and a glass container 43. The liquid collection port 41 is opened on the bottom surface of the placement groove 23 and the side wall is inclined. The collection frame 42 is movably arranged on the side wall of the cargo box 21. The three glass containers 43 are fixedly connected to the side wall of the collection frame 42 and are located below the liquid collection port 41.

[0035] In this embodiment: by providing a liquid collecting port 41, a collecting frame 42 and a glass container 43, when in use, the reagent leaking out of the reagent bottle 24 flows into the placement groove 23, and falls into the glass container 43 through the liquid collecting port 41. By pulling the collecting frame 42 away from the cargo box 21, the reagent in the glass container 43 can be cleaned. In this way, the reagent leaked from the reagent bottle 24 can be collected, and it is convenient to clean the collected reagent.

[0036] As a technical optimization solution of the utility model, multiple support frames 51 are fixedly connected to the top surface of the support plate 22, two support frames 51 form a group, and protective rings 52 are fixedly connected to the side walls of the two support frames 51, and the side walls of the protective rings 52 are in contact with the reagent bottle 24.

[0037] In this embodiment, by providing a support frame 51 and a protection ring 52 , the reagent bottle 24 placed in the placement groove 23 can be supported and protected.

[0038] As a technical optimization solution of the present invention, rubber pads 61 are bonded to the side walls and the bottom surface of the placement groove 23 , and the side walls of the rubber pads 61 are in contact with the reagent bottle 24 .

[0039] In this embodiment, the rubber pad 61 is provided to provide anti-collision and anti-slip protection for the reagent bottle 24 when it contacts the placement groove 23 .

[0040] As a technical optimization solution of the present invention, a heating ring 71 is embedded on the bottom surface of the placement groove 23 , and the top surface of the heating ring 71 is in contact with the reagent bottle 24 .

[0041] In this embodiment, by providing a heating ring 71 , the reagent bottle 24 can be heated at low temperatures.

[0042] As a technical optimization solution of the present invention, a top cover 81 is threadedly connected to the top of the glass container 43 , and a through hole 82 is opened in the middle of the top cover 81 .

[0043] In this embodiment, by providing the top cover 81 and the through hole 82 , the reagent collected in the glass container 43 can be protected to prevent the liquid in the glass container 43 from leaking when the collection frame 42 is taken out.

[0044] As a technical optimization solution of the present invention, three guide rings 9 are fixedly connected to the bottom surface of the support plate 22 , and the guide rings 9 are located below the liquid collection port 41 .

[0045] In this embodiment, the guide ring 9 is provided to guide the reagent falling from the liquid collection port 41 to prevent the reagent from remaining on the bottom surface of the support plate 22 .

[0046] As a technical optimization solution of the present invention, the side wall at the top of the placement groove 23 is inclined.

[0047] In this embodiment, by providing the top side wall of the placement groove 23 with an inclined arrangement, the reagent bottle 24 can be easily placed in the placement groove 23 .

[0048] Working principle: First, push the lock sleeve 35 to squeeze the spring 36. At this time, the spring 36 contracts, and the lock sleeve 35 moves away from the hinged part of the hinged column 33 and the fixed column 32. At this time, push the hinged column 33 to drive the limit cover 34 to move upward, and put the reagent bottle 24 to be tested into the placement groove 23. The support frame 51 and the protective ring 52 support and protect the reagent bottle 24 placed in the placement groove 23. Then put the reagent bottle 24 into the placement groove 23, pull the hinged column 33 and the fixed column 32 to be horizontal, and the limit cover 34 is put on the reagent bottle 24. Release the lock sleeve 35 to squeeze the spring 36. At this time, the spring 36 resets and pushes the lock sleeve 35 on the fixed column 32 and the hinged column 33 The limit ring 37 limits the movement range of the locking sleeve 35. The locking sleeve 35 is located at the connecting part of the hinge column 33 and the fixed column 32. At this time, the hinge column 33 and the fixed column 32 cannot move. When the reagent leaked from the reagent bottle 24 flows into the placement groove 23, it falls into the glass container 43 through the liquid collection port 41. The reagent in the glass container 43 can be cleaned by pulling the collection frame 42 away from the cargo box 21. In this way, the reagent leaked from the reagent bottle 24 can be collected, and it is convenient to clean the collected reagent. The reagent bottle 24 placed in the placement groove 23 can be clamped and limited to prevent the reagent bottle 24 from tipping over inside the placement groove 23.

[0049] The above are only preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. An analytical device for cyanoacetic acid high performance liquid chromatography, comprising a liquid chromatograph body (1), characterized in that: A material carrier box (21) is arranged on the top of the liquid chromatograph body (1); a support plate (22) is fixedly connected to the inner wall of the material carrier box (21); three placement grooves (23) are arranged at equal intervals on the top surface of the support plate (22); reagent bottles (24) are placed inside the placement grooves (23); a protection mechanism (3) for limiting the position of the reagent bottles (24) is arranged on the top surface of the support plate (22); and a liquid collection mechanism (4) is arranged on the side wall of the material carrier box (21); The protective mechanism (3) comprises a fixed plate (31), a fixed column (32), a hinged column (33), a limit cover (34), a locking sleeve (35), a spring (36) and a limit ring (37), wherein the three fixed plates (31) are fixedly connected to the top surface of the support plate (22), the fixed column (32) is fixedly connected to the side wall of the support plate (22), and the hinged column (33) is hingedly connected to one end of the fixed column (32) away from the fixed plate (31). The limiting cover (34) is fixedly connected to one end of the hinged column (33) away from the fixed column (32) and is engaged with the top of the reagent bottle (24); the locking sleeve (35) is sleeved on the side walls of the fixed column (32) and the hinged column (33); the spring (36) is sleeved on the side wall of the fixed column (32) and its two ends are respectively fixedly connected to the locking sleeve (35) and the fixed plate (31); the limiting ring (37) is fixedly connected to the side wall of the hinged column (33).

2. The analytical device of a cyanoacetic acid high performance liquid chromatography according to claim 1, characterized in that: The liquid collection mechanism (4) comprises a liquid collection port (41), a collection frame (42) and a glass container (43); the liquid collection port (41) is opened on the bottom surface of the placement groove (23) and the side wall is inclined; the collection frame (42) is movably arranged on the side wall of the object carrying box (21); and the three glass containers (43) are fixedly connected to the side wall of the collection frame (42) and are located below the liquid collection port (41).

3. The analytical device of a cyanoacetic acid high performance liquid chromatography according to claim 1, characterized in that: A plurality of support frames (51) are fixedly connected to the top surface of the support plate (22), two of the support frames (51) form a group, and a protective ring (52) is fixedly connected to the side walls of the two support frames (51), and the side walls of the protective ring (52) are in contact with the reagent bottle (24).

4. The analytical device of a cyanoacetic acid high performance liquid chromatography according to claim 1, characterized in that: A rubber pad (61) is bonded to the side wall and the bottom surface of the placement groove (23), and the side wall of the rubber pad (61) is in contact with the reagent bottle (24).

5. The analytical device of a cyanoacetic acid high performance liquid chromatography according to claim 1, characterized in that: A heating ring (71) is embedded on the bottom surface of the placement groove (23), and the top surface of the heating ring (71) is in contact with the reagent bottle (24).

6. The analytical device of a cyanoacetic acid high performance liquid chromatography according to claim 2, characterized in that: A top cover (81) is threadedly connected to the top of the glass container (43), and a through hole (82) is provided in the middle of the top cover (81).

7. The analytical device of a cyanoacetic acid high performance liquid chromatography according to claim 1, characterized in that: Three guide rings (9) are fixedly connected to the bottom surface of the support plate (22), and the guide rings (9) are located below the liquid collection port (41).

8. The analytical device of a cyanoacetic acid high performance liquid chromatography according to claim 1, characterized in that: The side wall at the top of the placement groove (23) is arranged to be inclined.

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