Extraction device and sample purification detection equipment

Abstract

The utility model discloses an extraction device and sample purification detection equipment, and belongs to the technical field of automatic sample purification detection, an extraction assembly comprises an extraction tube and a sample adding and pressurizing device, the sample adding and pressurizing device comprises an adapter and a plurality of output tubes, the plurality of output tubes penetrate through the adapter, at least one output tube is configured to be a gas injection tube, and the gas injection tube is configured to be a gas injection tube. At least one output pipe is configured to be a liquid injection pipe, a cavity is formed in the extraction pipe, the extraction assembly has a combined state, in the combined state, part of the structure of the adapter extends into the cavity and is in sealing fit with the inner wall of the cavity, and the output pipes are communicated with the cavity. Meanwhile, the gas injection pipe can inject gas into the extraction pipe for pressurization, the steps of reagent injection and pressurization can be completed at the same time, and the extraction efficiency is improved.

Description

Technical Field

[0001] The utility model relates to the technical field of automated sample purification and detection, in particular to an extraction device and sample purification and detection equipment. Background Art

[0002] It should be noted that during the sample reagent purification and detection experiment, it is usually necessary to perform an extraction operation on the sample reagent. At present, in order to automatically complete the extraction operation, an automatic extraction device is designed on the market. For the existing automatic extraction device, a moving mechanism is usually used to move the extraction tube to the bottom of the liquid adding head and the gas adding head respectively, so as to add reagents and pressurize the extraction tube to complete the extraction. This will cause the moving mechanism to move the extraction tube multiple times, with more operating steps and lower extraction efficiency. Utility Model Content

[0003] The utility model aims to at least solve the technical problem of low extraction efficiency in the prior art. To this end, the utility model provides an extraction device that can reduce the operation steps and improve the extraction efficiency.

[0004] The utility model also provides sample purification detection equipment with the extraction device.

[0005] According to a first aspect of the utility model, an extraction device is provided, comprising: an extraction component, comprising an extraction tube and a sample adding and pressurizing device, the sample adding and pressurizing device comprising an adapter and a plurality of output tubes, the plurality of output tubes being passed through the adapter, at least one of the output tubes being configured as an air injection tube, and at least one of the output tubes being configured as a liquid injection tube, a cavity being provided inside the extraction tube, the extraction component having a combined state, in which a partial structure of the adapter extends into the cavity and is sealed with an inner wall of the cavity, and the output tube is connected to the cavity.

[0006] The extraction device according to the embodiment of the utility model has at least the following beneficial effects:

[0007] By arranging multiple output tubes to be connected with the adapter, and at least one output tube is configured as a gas injection tube, and at least one output tube is configured as a liquid injection tube, when the extraction tube and the adapter are in a combined state, the liquid injection tube can inject reagent into the cavity of the extraction tube, and at the same time the gas injection tube can also inject gas into the extraction tube for pressurization, so that the liquid quickly passes through the filter element in the extraction tube and drips downward, thereby reducing the extraction time, and the steps of injecting reagent and pressurizing can be completed at the same time, without moving the extraction tube to the bottom of the liquid adding head and the gas adding head respectively, which can reduce the operation steps and improve the extraction efficiency.

[0008] According to some embodiments of the utility model, the sample adding and pressurizing device includes a plurality of connecting tubes, the plurality of connecting tubes correspond one-to-one to the plurality of output tubes, and a connecting nozzle is provided at the upper end of the output tube, and the connecting nozzle is connected to the connecting tube.

[0009] According to some embodiments of the utility model, the extraction tube is provided with a rib portion, and the extraction component has a separated state. In the separated state, the extraction tube is separated from the sample loading and pressurizing device. The extraction device also includes a tube-detaching component, and the tube-detaching component includes a tube-detaching rack, a first lifting mechanism and a horizontal telescopic mechanism. The first lifting mechanism is used to drive the sample loading and pressurizing device to perform lifting and lowering movements, and the horizontal telescopic mechanism is used to drive the tube-detaching rack to perform horizontal telescopic movements. When the tube-detaching rack extends to the top of the rib portion and the first lifting mechanism lifts the sample loading and pressurizing device, the tube-detaching rack can abut against the rib portion to switch the extraction component from the combined state to the separated state.

[0010] According to some embodiments of the utility model, the tube removal assembly also includes a first limiting device and / or a second limiting device, the first limiting device is used to limit the range of travel of the lifting and lowering movement of the sample loading and pressurizing device, and the second limiting device is used to limit the range of travel of the horizontal telescopic movement of the sample loading and pressurizing device.

[0011] According to a second aspect of the utility model, a sample purification detection device is provided, comprising the extraction device of the embodiment of the first aspect.

[0012] The sample purification detection device according to the embodiment of the utility model has at least the following beneficial effects:

[0013] The sample purification detection equipment adopts the extraction device of the first aspect embodiment, and is connected to the adapter by arranging multiple output tubes, and at least one output tube is configured as a gas injection tube, and at least one output tube is configured as a liquid injection tube. When the extraction tube and the adapter are in a combined state, the liquid injection tube can inject reagent into the cavity of the extraction tube, and at the same time, the gas injection tube can also inject gas into the extraction tube for pressurization. The steps of injecting reagent and pressurizing can be completed at the same time, and there is no need to move the extraction tube to the bottom of the liquid adding head and the gas adding head respectively, which can reduce the operation steps and improve the extraction efficiency.

[0014] According to some embodiments of the utility model, the sample purification detection equipment also includes a pipe transport device, a nitrogen blowing and drying device, a pipetting device and a fluorescence reading device, the pipe transport device includes a turntable, a rotating mechanism, a second lifting mechanism and multiple collecting tubes, the collecting tube is used to collect the reagent in the extraction tube, multiple collecting tubes and multiple extraction tubes are placed on the turntable and arranged along the circumference of the turntable, the rotating mechanism is used to drive the turntable to rotate, the second lifting mechanism is used to drive at least one of the collecting tubes to perform lifting and lowering movements, the nitrogen blowing and drying device is used to perform nitrogen blowing and drying on the collecting tube, the pipetting device includes a pipette and a swing arm mechanism, the pipette can absorb or release liquid, when the second lifting mechanism lifts the collecting tube, the pipette can extend into the collecting tube, and the swing arm mechanism is used to drive the pipette to swing back and forth from the collecting tube to the fluorescence reading device.

[0015] According to some embodiments of the utility model, the nitrogen blowing drying device includes a nitrogen blowing pipe, a third lifting mechanism, an air pump assembly and a nitrogen heating assembly. The third lifting mechanism is used to drive the nitrogen blowing pipe to perform lifting and lowering movements. The air pump assembly can provide nitrogen to the nitrogen blowing pipe. The nitrogen heating assembly is connected between the nitrogen blowing pipe and the air pump assembly.

[0016] According to some embodiments of the present utility model, the nitrogen blowing drying device further includes a third limiting device, and the third limiting device is used to limit the travel range of the lifting and lowering movement of the nitrogen blowing tube.

[0017] According to some embodiments of the present utility model, the sample purification detection equipment also includes a machine platform and a machine cover, the extraction device, the pipe transport device, the nitrogen blowing and drying device, the pipetting device and the fluorescence reading device are all arranged on the top of the machine platform, and the machine cover is located on the top of the machine platform and is rotatably connected to the machine platform to seal the extraction device, the pipe transport device, the nitrogen blowing and drying device, the pipetting device and the fluorescence reading device.

[0018] Additional aspects and advantages of the present invention will be given in part in the following description, and in part will become apparent from the following description, or will be learned through the practice of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] The present invention is further described below with reference to the accompanying drawings and embodiments, wherein:

[0020] Figure 1 It is a schematic diagram of the structure of the adapter and the output tube of the extraction device of some embodiments of the utility model;

[0021] Figure 2 An exploded view of an adapter and an output tube of an extraction device according to some embodiments of the present invention;

[0022] Figure 3 It is a schematic diagram of the structure of the extraction device of some embodiments of the utility model;

[0023] Figure 4 An exploded view of an extraction device according to some embodiments of the present invention;

[0024] Figure 5 An exploded view of an extraction assembly and a first lifting mechanism of an extraction device according to some embodiments of the present utility model;

[0025] Figure 6 An exploded view of a horizontal telescopic mechanism of an extraction device according to some embodiments of the present invention;

[0026] Figure 7 It is a schematic diagram of the structure of the sample purification detection equipment of some embodiments of the utility model;

[0027] Figure 8 for Figure 7 The enlarged view of point A in the middle;

[0028] Fig. 9 This is a schematic diagram of the structure of the sample purification detection equipment of some embodiments of the utility model (with the cover hidden);

[0029] Fig.10 It is a schematic diagram of the structure of the transport and management device of the sample purification and detection equipment of some embodiments of the utility model;

[0030] Fig.11 A schematic diagram of the structure of a third lifting mechanism and a nitrogen blow pipe of a nitrogen blow drying device of a sample purification and detection device in some embodiments of the utility model;

[0031] Fig.12 This is an exploded view of the third lifting mechanism and the nitrogen blow pipe of the nitrogen blow drying device of the sample purification and detection equipment in some embodiments of the utility model.

[0032] Figure Number:

[0033] Sample purification and testing equipment 1000;

[0034] Extraction device 100, extraction assembly 110, extraction tube 111, rib plate portion 1111, sample adding and pressurizing device 112, adapter 113, annular groove 1131, mounting hole 1132, output tube 114, gas injection tube 115, liquid injection tube 116, connecting tube 117, sealing ring 118, connecting nozzle 119, tube removal assembly 120, tube removal rack 121, tube removal groove 1211, first lifting mechanism 122, first motor 1221, first screw rod 1222, first slider 1223, first slide rail 12 24. first synchronous belt 1225, first synchronous wheel 1226, connecting block 1227, first mounting plate 1228, horizontal telescopic mechanism 123, second motor 1231, second slider 1232, second slide rail 1233, second mounting plate 1234, bottom plate 124, supporting frame 125, first limiting device 126, first photoelectric baffle 1261, first photoelectric switch 1262, second limiting device 127, second photoelectric baffle 1271, second photoelectric switch 1272, limiting baffle 1273;

[0035] The transport and management device 200, the turntable 210, the rotating mechanism 220, the second lifting mechanism 230, the collecting pipe 240, and the supporting part 241;

[0036] Nitrogen blowing drying device 300, nitrogen blowing pipe 310, third lifting mechanism 320, third motor 321, third screw rod 322, nut 323, lifting plate 324, drag chain 325, third slider 326, third slide rail 327, air pump assembly 330, first air pump 331, second air pump 332, nitrogen heating assembly 340, third limiting device 350, third photoelectric baffle 351, third photoelectric switch 352;

[0037] Liquid transfer device 400, pipette 410, swing arm mechanism 420;

[0038] Fluorescence reading device 500;

[0039] The machine platform 600 and the machine cover 610 . DETAILED DESCRIPTION

[0040] The embodiments of the present invention are described in detail below, and examples of the embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements having the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present invention, and cannot be understood as limiting the present invention.

[0041] Reference Figure 3 As shown in FIG. 1 , an extraction device 100 according to an embodiment of the present invention is shown. The extraction device 100 includes an extraction component 110. The extraction component 110 includes an extraction tube 111 and a sample adding and pressurizing device 112. Figure 1 and Figure 2 As shown, the sample adding and pressurizing device 112 includes an adapter 113 and a plurality of output tubes 114. The plurality of output tubes 114 are inserted through the adapter 113. The output tubes 114 extend in the up-down direction. The adapter 113 also extends in the up-down direction. At least one output tube 114 is configured as a gas injection tube 115, and at least one output tube 114 is configured as a liquid injection tube 116. Specifically, referring to Figure 2 As shown, the adapter 113 is provided with a mounting hole 1132 for the output tube 114 to pass through. The mounting hole 1132 penetrates the adapter 113 in the up and down directions. The number of the mounting holes 1132 corresponds to the number of the output tubes 114. The gap between the output tube 114 and the mounting hole 1132 can be sealed by gluing.

[0042] Reference Figure 1 As shown, in some embodiments, the number of output tubes 114 is four, one of which is a gas injection tube 115, and the other three are liquid injection tubes 116, one of which is used to inject methanol, one is used to inject distilled water, and one is used to inject sample reagents, and the liquid in the liquid injection tube 116 flows from top to bottom. In other embodiments, the number of output tubes 114 can be set according to actual needs.

[0043] Reference Figure 5 As shown, the extraction tube 111 is provided with a cavity inside, and a filter element is provided at the lower end of the cavity. The extraction assembly 110 has a combined state and a separated state. Figure 3 As shown, in the assembled state, part of the structure of the adapter 113 extends into the cavity of the extraction tube 111 and seals with the inner wall of the extraction tube 111, so that the output tube 114 is connected to the cavity. The seal can prevent the leakage of sample reagents or pressurized gas. The extraction tube 111 and the adapter 113 are both arranged vertically. Figure 5 As shown, in the separated state, the adapter 113 is separated from the extraction tube 111 .

[0044] In this embodiment, a plurality of output tubes 114 are arranged to be connected to the adapter 113, and at least one of the output tubes 114 is configured as a gas injection tube 115, and at least one of the output tubes 114 is configured as a liquid injection tube 116. When the extraction tube 111 and the adapter 113 are in a combined state, the liquid injection tube 116 can inject liquids such as methanol, distilled water and sample reagents into the cavity of the extraction tube 111, and the gas injection tube 115 can also inject gas, such as air, into the extraction tube 111 to pressurize it, so that the liquid quickly passes through the filter element in the extraction tube 111 and drips downward, thereby reducing the extraction time, and the steps of injecting the sample reagent and pressurizing can be completed at the same time. There is no need to move the extraction tube 111 to the bottom of the liquid adding head and the gas adding head respectively to perform the steps of adding liquid and adding gas respectively, which can reduce the operation steps and improve the extraction efficiency.

[0045] Reference Figure 1 and Figure 5 As shown, in some embodiments, the outer peripheral wall of the adapter 113 is provided with an annular groove 1131, and a sealing ring 118 is provided in the annular groove 1131. When the adapter 113 is inserted into the cavity of the extraction tube 111, the adapter 113 can be sealed with the extraction tube 111 through the sealing ring 118. In addition, since the sealing ring 118 is elastic, the adapter 113 will press the sealing ring 118 after being sealed with the extraction tube 111, and the extraction tube 111 can be driven to rise together when the adapter 113 rises. There can be multiple annular grooves 1131, and there can be multiple sealing rings 118, and multiple annular grooves 1131 correspond to multiple sealing rings 118 one by one. In some other embodiments, the outer peripheral wall of the adapter 113 can be pressed against the inner peripheral wall of the extraction tube 111 to achieve a sealed fit, that is, the adapter 113 and the extraction tube 111 have an interference fit.

[0046] Reference Figure 3 As shown, it can be understood that, in some embodiments, the sample adding and pressurizing device 112 also includes a plurality of connecting tubes 117, and the plurality of connecting tubes 117 correspond one by one to the plurality of output tubes 114. The texture of the connecting tube 117 is relatively soft and can be understood as a hose. The texture of the output tube 114 is relatively hard and can be understood as a steel needle. The length of the connecting tube 117 is greater than the length of the output tube 114. The connecting tube 117 is mainly used to connect the output tube 114 to the liquid supply device or the gas supply device, so that the gas or liquid can be transmitted to the output tube 114 through the connecting tube 117. The upper end of the output tube 114 is provided with a connection nozzle 119, which is a roughly conical structure. The outer diameter of the connection nozzle 119 gradually decreases in the direction away from the output tube 114. The connection nozzle 119 is used to connect with the connection tube 117. The connection nozzle 119 can be directly inserted into the connection tube 117 to achieve clamping, which is convenient for installation and connection. The connection nozzle 119 can be understood as an inverted structure, which can improve the sealing effect between the connection tube 117 and the output tube 114 and prevent air leakage and liquid leakage. In some other embodiments, the connection nozzle 119 can also be a buckle structure or a roughly conical structure.

[0047] Reference Figure 1 As shown, in some embodiments, the adapter 113 is a roughly cylindrical structure, wherein the plurality of output tubes 114 can be arranged along the circumference of the adapter 113, and the upper ends of the output tubes 114 are inclined away from the axis of the adapter 113, so that a certain gap can be left between the plurality of output tubes 114 to facilitate the connection between the connection nozzle 119 and the connection tube 117. In some embodiments, referring to Figure 1As shown, there are four output pipes 114, one of which is an air injection pipe 115, and the other three are liquid injection pipes 116. The three liquid injection pipes 116 are arranged at intervals along the circumference of the air injection pipe 115. It can also be understood that the three liquid injection pipes 116 surround the air injection pipe 115, which can make full use of the space. The upper end of the liquid injection pipe 116 is inclined in a direction away from the axis of the adapter 113, thereby forming an inclined section, so that the upper end of the liquid injection pipe 116 deviates from the air injection pipe 115. It can also be understood that at the position of the inclined section, the distance from the liquid injection pipe 116 to the air injection pipe 115 gradually decreases upward, and a certain amount of space can be reserved to facilitate the connection of the connecting nozzle 119 and the connecting pipe 117.

[0048] It is understandable that, referring to Figure 3 and Figure 4 As shown, the extraction device 100 further includes a tube removal assembly 120, which includes a tube removal frame 121, a first lifting mechanism 122 and a horizontal telescopic mechanism 123. The first lifting mechanism 122 is used to drive the sample loading and pressurizing device 112 to perform lifting and lowering movements, and the horizontal telescopic mechanism 123 is used to drive the tube removal frame 121 to perform horizontal telescopic movements. Figure 5 As shown, the extraction tube 111 is provided with a rib portion 1111, referring to Figure 6 As shown, the tube removal rack 121 is provided with a tube removal groove 1211 , which is U-shaped and is used to cooperate with the adapter 113 .

[0049] Specifically, during extraction, the extraction tube 111 is located below the sample adding and pressurizing device 112, and the first lifting mechanism 122 drives the sample adding and pressurizing device 112 to descend, so that the adapter 113 extends into the extraction tube 111 and seals with the extraction tube 111, that is, the extraction assembly 110 switches from a separated state to a combined state, and then, the liquid injection tube 116 injects methanol, distilled water and sample reagent into the extraction tube 111, and the gas injection tube 115 injects gas into the extraction tube 111 to achieve pressurization. After the extraction step is completed, the horizontal telescopic mechanism 123 drives the tube removal rack 121 to extend, so that the adapter 113 is inserted into the extraction tube 111 and seals with the extraction tube 111. The adapter 113 extends into the tube removal groove 1211 of the tube removal rack 121, and makes the tube removal rack 121 located above the rib plate portion 1111. Then, the first lifting mechanism 122 drives the sample adding and pressurizing device 112 to rise. At this time, the bottom wall of the tube removal rack 121 will abut against the top wall of the rib plate portion 1111, thereby limiting the upward movement of the extraction tube 111. It can be understood that the first lifting mechanism 122 drives the adapter 113 to rise relative to the extraction tube 111, thereby separating the extraction tube 111 from the adapter 113, completing the tube removal, that is, the extraction assembly 110 is switched from the combined state to the separated state. In this embodiment, the extraction device 100 can automatically complete the extraction and tube removal steps without manual operation, which can improve the extraction efficiency.

[0050] Reference Figure 5As shown, the first lifting mechanism 122 includes a first motor 1221, a first screw rod 1222, a first slider 1223, a first slide rail 1224, a first synchronous belt 1225, two first synchronous wheels 1226 and a connecting block 1227. The first slide rail 1224 extends in the up-down direction, the first slider 1223 is slidably connected to the first slide rail 1224, the connecting block 1227 is L-shaped, the adapter 113 is connected to the connecting block 1227, and the connecting block 1227 is connected to the first slider 12 23. The first screw rod 1222 extends in the up-down direction. The first screw rod 1222 is threadedly connected to the first slider 1223. The two first synchronous wheels 1226 are connected through the first synchronous belt 1225. The output shaft of the first motor 1221 drives one of the first synchronous wheels 1226 to rotate, and the other first synchronous wheel 1226 drives the first screw rod 1222 to rotate. The first screw rod 1222 can drive the first slider 1223 to move in the up-down direction, thereby driving the adapter 113 to perform lifting movement.

[0051] In some other embodiments, the first lifting mechanism 122 may also use a driving component such as a linear motor module or a cylinder module to drive the sample loading and pressurizing device 112 to perform lifting movement.

[0052] Reference Figure 6 As shown, the horizontal telescopic mechanism 123 includes a second motor 1231, a second screw rod, a second slider 1232, a second slide rail 1233 and a second mounting plate 1234. The second slide rail 1233 is mounted on the second mounting plate 1234, the second slide rail 1233 extends in the front-to-back direction, the second slider 1232 is slidably connected to the second slide rail 1233, the tube-removing rack 121 is in an L-shaped structure, the tube-removing rack 121 is connected to the second slider 1232, the second screw rod extends in the front-to-back direction, the second screw rod is threadedly connected to the tube-removing rack 121, the output shaft of the second motor 1231 drives the second screw rod to rotate, and the second screw rod can drive the tube-removing rack 121 to move in the front-to-back direction, thereby driving the tube-removing rack 121 to perform horizontal telescopic movement. The combination of the second slider 1232 and the second slide rail 1233 can improve the movement accuracy of the tube-removing rack 121 and ensure that the tube-removing rack 121 moves in place.

[0053] In some other embodiments, the horizontal telescopic mechanism 123 may also use a driving component such as a linear motor module or a cylinder module to drive the tube removal rack 121 to perform horizontal telescopic movement.

[0054] It is understandable that, referring to Figure 3 and Figure 4As shown, in some embodiments, the extraction device 100 further includes a bottom plate 124 and a support frame 125, the support frame 125 is disposed on the bottom plate 124, the horizontal telescopic mechanism 123 is disposed on the support frame 125, the horizontal telescopic mechanism 123 is located below the first lifting mechanism 122, and the support frame 125 is provided with an avoidance space for avoiding the tube removal frame 121. The first lifting mechanism 122 generally extends in the up-down direction, and the horizontal telescopic mechanism 123 generally extends in the front-back direction. The horizontal telescopic mechanism 123 is arranged below the first lifting mechanism 122 to reduce the occupied space. Specifically, the support frame 125 can be a concave structure, and the support frame 125 can be a single component or composed of multiple plates.

[0055] It is understood that in some embodiments, reference Figure 5 As shown, the tube removal assembly 120 further includes a first limit device 126 , and the first limit device 126 is used to limit the travel range of the lifting and lowering movement of the sample loading and pressurizing device 112 . The first limiting device 126 includes a first photoelectric baffle 1261 and a first photoelectric switch 1262. The first photoelectric baffle 1261 is in an L-shaped structure. The first photoelectric baffle 1261 is connected to the connecting block 1227. The first lifting mechanism 122 includes a first mounting plate 1228. The first mounting plate 1228 is located at the top position of the first lifting mechanism 122. The position of the first mounting plate 1228 is fixed. The first photoelectric switch 1262 is connected to the first mounting plate 1228. When the first lifting mechanism 122 drives the sample adding and pressurizing device 112 to perform a lifting movement, the connecting block 1227 will also drive the first photoelectric baffle 1261 to lift together. When the first photoelectric baffle 1261 moves to the first photoelectric switch 1262, the first photoelectric switch 1262 can sense the first photoelectric baffle 1261, thereby judging that the sample adding and pressurizing device 112 has risen to the position, and can control the first motor 1221 to stop working, so as to avoid collision and play a protective role. Similarly, the number of the first limiting devices 126 can be two, and the two first limiting devices 126 are used to determine whether the sample adding and pressurizing device 112 has risen to the position and whether it has fallen to the position. In some other embodiments, the above-mentioned first photoelectric baffle 1261 and the first photoelectric switch 1262 can also be replaced by other types of proximity switches, such as inductive, magnetic induction or ultrasonic proximity switches. In some other embodiments, the first limiting device 126 can include a limiting block, the position of the limiting block is fixed, and when the connecting block 1227 moves to the limit position, the limiting block will prevent the connecting block 1227 from continuing to move, which can also play a limiting role.

[0056] It is understood that in some embodiments, reference Figure 6As shown, the tube removal assembly 120 also includes a second limiting device 127, which is used to limit the travel range of the horizontal telescopic movement of the sample loading and pressurizing device 112. The second limiting device 127 includes a second photoelectric baffle 1271 and a second photoelectric switch 1272. The position of the second photoelectric switch 1272 is fixed and unchanged. The second photoelectric baffle 1271 is connected to the tube removal rack 121. When the horizontal telescopic mechanism 123 drives the tube removal rack 121 to move, the second photoelectric baffle 1271 moves together with the tube removal rack 121. When the second photoelectric baffle 1271 moves to the second photoelectric switch 1272, the second photoelectric switch 1272 can sense the second photoelectric baffle 1271, thereby judging that the tube removal rack 121 has moved to the position, and the second motor 1231 can be controlled to stop working to avoid collision and play a protective role. Similarly, the number of the first limiting device 126 can be two, and the two first limiting devices 126 are respectively used to judge whether the tube removal rack 121 is extended to the position and whether it is retracted to the position. In some other embodiments, the first photoelectric baffle 1261 and the first photoelectric switch 1262 may be replaced by other types of proximity switches, such as inductive, magnetic or ultrasonic proximity switches. In some other embodiments, the first limit device 126 may include a limit baffle 1273, which is connected to the second mounting plate 1234. The position of the limit baffle 1273 remains fixed. When the tube-removing rack 121 moves to the limit position, the limit baffle 1273 will block the second slider 1232 from continuing to move, which can also play a limiting role.

[0057] Reference Figure 7 As shown, sample purification detection equipment 1000 of some embodiments of the present invention is shown. The sample purification detection equipment 1000 includes the extraction device 100 of the above embodiment, which can realize the steps of automatic extraction without manual operation, thereby reducing labor intensity and improving extraction efficiency.

[0058] Reference Figure 7 and Figure 8 As shown, in some embodiments, the sample purification detection device 1000 further includes a transport device 200, a nitrogen blowing drying device 300, a liquid transfer device 400 and a fluorescence reading device 500. The transport device 200 can transport the collection tube 240 and the extraction tube 111, the nitrogen blowing drying device 300 is used to nitrogen blow dry the collection tube 240, and the liquid transfer device 400 is mainly used to absorb the sample reagent in the collection tube 240 onto the reagent card of the fluorescence reading device 500.

[0059] Specifically, refer to Figure 8 and Fig.10As shown, the transport and management device 200 includes a turntable 210, a rotating mechanism 220, a second lifting mechanism 230 and a plurality of collecting tubes 240. The collecting tubes 240 are used to collect sample reagents in the extraction tubes 111. The plurality of collecting tubes 240 and the plurality of extraction tubes 111 are placed on the turntable 210 and arranged along the circumference of the turntable 210. The turntable 210 may be a disc structure, and a plurality of through holes are provided on the turntable 210. The plurality of through holes are arranged along the circumference of the turntable 210, and the through holes penetrate the turntable 210 along the axial direction of the turntable 210. The plurality of through holes are arranged one by one correspondingly with the plurality of extraction tubes 111 and the plurality of collecting tubes 240. The extraction tube 111 can be placed in the through hole, and the rib plate portion 1111 of the extraction tube 111 abuts against the top wall of the turntable 210 to support the extraction tube 111. Similarly, part of the outer peripheral wall of the collection tube 240 extends radially outward to form a support portion 241, and the support portion 241 also extends along the circumference of the collection tube 240. The support portion 241 is an annular structure. The collection tube 240 can be placed in the through hole, and the support portion 241 abuts against the top wall of the turntable 210 to support the collection tube 240. The rotating mechanism 220 is used to drive the turntable 210 to rotate. The rotating mechanism 220 can use a motor or a rotating cylinder or other driving member to drive the turntable 210 to rotate. The second lifting mechanism 230 is used to drive at least one collection tube 240 to perform lifting motion. The second lifting mechanism 230 can use a screw motor module, a linear motor module or a cylinder module or other driving member to drive the collection tube 240 to perform lifting motion.

[0060] Reference Figure 8 As shown, the pipette device 400 includes a pipette 410 and a swing arm mechanism 420. The pipette 410 can be connected to the pump body so that the pipette 410 can absorb or release liquid. The pipette 410 extends in the up-down direction. When the second lifting mechanism 230 lifts the collection tube 240 located directly below the pipette 410, the pipette 410 can extend into the collection tube 240. The swing arm mechanism 420 can drive the pipette 410 to swing back and forth from the collection tube 240 to the fluorescence reading device 500. Specifically, the swing arm mechanism 420 can be driven to move by a driving member such as a motor or a rotary cylinder. The swing arm mechanism 420 is an L-shaped structure, and the swing arm mechanism 420 swings with the up-down direction as the rotation axis.

[0061] It is understandable that, referring to Fig. 9 and Fig.11As shown, the nitrogen blowing drying device 300 includes a nitrogen blowing pipe 310, a third lifting mechanism 320, an air pump assembly 330 and a nitrogen heating assembly 340. The third lifting mechanism 320 is used to drive the nitrogen blowing pipe 310 to do lifting and lowering movements. The air pump assembly 330 can provide nitrogen to the nitrogen blowing pipe 310. The nitrogen heating assembly 340 is connected between the nitrogen blowing pipe 310 and the air pump assembly 330. The nitrogen is first heated by the nitrogen heating assembly 340 and then flows out of the nitrogen blowing pipe 310, which can improve the drying effect. Specifically, the nitrogen heating assembly 340 can heat the nitrogen through a heating member such as a heating plate, a heating tube or a heating wire.

[0062] In some embodiments, reference Fig. 9 As shown, the air pump assembly 330 is located below the third lifting mechanism 320, and the air pump assembly 330 is located on the rear side of the sample purification detection equipment 1000. The air pump assembly 330 includes a first air pump 331 and a second air pump 332. The first air pump 331 is used to provide nitrogen to the nitrogen blowpipe 310, and the second air pump 332 is used to provide air to the gas injection pipe 115. Integrating the first air pump 331 and the second air pump 332 together can reduce the occupied space.

[0063] Reference Fig.12 As shown, the third lifting mechanism 320 includes a third motor 321, a third screw rod 322, a nut 323, a lifting plate 324, a drag chain 325, a third slider 326 and a third slide rail 327. The third screw rod 322 extends in the up-down direction. The third motor 321 can drive the third screw rod 322 to rotate. The nut 323 is threadedly connected to the third screw rod 322. The nut 323 is connected to the lifting plate 324. The third slide rail 327 extends in the up-down direction. The third slider 326 is slidably connected to the third slide rail 327. The third slider 326 is connected to the lifting plate 324. The nitrogen blowpipe 310 is connected to the lifting plate 324. When the third screw rod 322 rotates, the lifting plate 324 can be driven to do lifting motion. The drag chain 325 can be used to protect the pipeline connecting the nitrogen blowpipe 310 and the air pump assembly 330. The combination of the third slider 326 and the third slide rail 327 can improve the accuracy of the lifting motion of the nitrogen blowpipe 310 and ensure that the nitrogen blowpipe 310 moves in place.

[0064] In some other embodiments, the third lifting mechanism 320 may also use a driving component such as a linear motor module or a cylinder module to drive the nitrogen blowpipe 310 to perform lifting motion.

[0065] It is understood that in some embodiments, reference Fig.11 and Fig.12 As shown, the nitrogen blowing device further includes a third limiting device 350, and the third limiting device 350 is used to limit the range of travel of the lifting movement of the nitrogen blowing tube 310. Fig.11 and Fig.12As shown, the third limiting device 350 includes a third photoelectric baffle 351 and a third photoelectric switch 352. The third photoelectric baffle 351 is connected to the lifting plate 324. The position of the third photoelectric switch 352 is fixed. When the third lifting mechanism 320 drives the nitrogen blowpipe 310 to do lifting and lowering movement, it will also drive the third photoelectric baffle 351 to move together. When the third photoelectric baffle 351 moves to the third photoelectric switch 352, the third photoelectric switch 352 can sense the third photoelectric baffle 351, thereby judging that the nitrogen blowpipe 310 has moved to the right position, and the third motor 321 can be controlled to stop working to avoid collision, thereby playing a protective role. Similarly, the number of the first limiting device 126 can be two, and the two third limiting devices 350 are respectively used to judge whether the nitrogen blowpipe 310 has risen to the right position and whether it has fallen to the right position. In some other embodiments, the third photoelectric baffle 351 and the third photoelectric switch 352 can also be replaced by other types of proximity switches, such as inductive, magnetic induction or ultrasonic proximity switches. In some other embodiments, the third limiting device 350 may include a limiting block, the position of which is fixed. When the lifting plate 324 moves to the extreme position, the limiting block will prevent the lifting plate 324 from continuing to move, which can also play a limiting role.

[0066] It is understood that in some embodiments, reference Figure 7 As shown, the sample purification detection equipment 1000 also includes a machine 600 and a machine cover 610. The extraction device 100, the transportation and management device 200, the nitrogen blowing and drying device 300, the pipetting device 400 and the fluorescence reading device 500 are all arranged on the top of the machine 600. The machine cover 610 is located on the top of the machine 600 and is rotatably connected to the machine 600. After the machine cover 610 is closed, it can provide an enclosed cavity. The extraction device 100, the transportation and management device 200, the nitrogen blowing and drying device 300, the pipetting device 400 and the fluorescence reading device 500 are all located in the enclosed cavity, so as to cover the extraction device 100, the transportation and management device 200, the nitrogen blowing and drying device 300, the pipetting device 400 and the fluorescence reading device 500, so as to avoid external contamination of the collection tube 240 or the extraction tube 111, and ensure the accuracy of the sample purification detection.

[0067] The following specifically introduces the workflow of the sample purification detection device 1000, which requires performing an extraction step, a nitrogen blowing and drying step, a cleaning step, and a pipetting step in sequence.

[0068] First, the extraction step is performed: the rotating mechanism 220 drives the turntable 210 to rotate, so that the turntable 210 drives the extraction tube 111 to move to the bottom of the sample adding and pressurizing device 112. It can be understood that the extraction tube 111 moves to the bottom of the adapter 113, so that the extraction tube 111 and the adapter 113 are aligned, and then the first lifting mechanism 122 drives the sample adding and pressurizing device 112 to descend, so that the adapter 113 is inserted into the extraction tube 111, and the extraction component 110 is switched from the separated state to the combined state, and the adapter 113 and the extraction tube 111 are sealed and matched. Then, the first lifting mechanism 122 drives the sample adding and pressurizing device 112 to rise together with the extraction tube 111, and the rotating mechanism 220 drives the turntable 210 to rotate, so that the collection tube 240 is transferred to the bottom of the extraction tube 111. At this time, the sample adding and pressurizing device 112 adds liquids such as methanol, distilled water and sample reagents into the extraction tube 111, and the liquid in the extraction tube 111 moves downward. The sample is dripped into the collection tube 240. At the same time, the sample adding and pressurizing device 112 also injects gas into the extraction tube 111 to achieve pressurization, which can squeeze out the residual sample liquid in the extraction tube 111. After collecting the residual sample liquid, the turntable 210 rotates so that the through hole with an empty space on the turntable 210 is located directly below the extraction tube 111. Then, the first lifting mechanism 122 drives the adapter 113 and the extraction tube 111 to descend together, so that the extraction tube 111 extends downward into the through hole of the turntable 210. At the same time, the horizontal telescopic mechanism 123 drives the tube removal rack 121 to extend above the rib plate portion 1111 of the extraction tube 111. Then, the first lifting mechanism 122 drives the adapter 113 to rise together. At this time, the bottom wall of the tube removal rack 121 will abut against the top wall of the rib plate portion 1111, and the extraction tube 111 will not rise with the adapter 113, thereby separating the adapter 113 from the extraction tube 111, completing the tube removal, and thus completing the extraction step.

[0069] Then, a nitrogen blowing drying step is performed: the rotating mechanism 220 drives the turntable 210 to rotate, and the turntable 210 drives the collecting tube 240 filled with the extract to move to the bottom of the nitrogen blowing tube 310, and the third lifting mechanism 320 drives the nitrogen blowing tube 310 to descend, and the nitrogen blowing tube 310 extends into the collecting tube 240, and the air pump assembly 330 and the nitrogen heating assembly 340 are started, and the heated nitrogen flows out from the nitrogen blowing tube 310, which can dry the extract in the collecting tube 240 and blow the extract into crystals.

[0070] Then, a cleaning step is performed: the rotating mechanism 220 drives the turntable 210 to rotate, and the turntable 210 moves the collecting tube 240 filled with the extract to just below the pipette 410. The second lifting mechanism 230 drives the collecting tube 240 to rise, so that the pipette 410 extends into the collecting tube 240. Then, the pipette 410 absorbs the internal standard solution and releases the internal standard solution into the collecting tube 240, thereby washing away the crystals adhering to the inner wall of the collecting tube 240. The crystals are mixed with the internal standard solution to form the final sample reagent.

[0071] Finally, the pipetting step is performed: the pipette 410 absorbs the final sample reagent in the collecting tube 240, the second lifting mechanism 230 drives the collecting tube 240 to descend, so that the pipette 410 is separated from the collecting tube 240, and then, the swing arm mechanism 420 drives the pipette 410 to swing, so that the pipette 410 moves to the position of the fluorescence reading device 500, and the pipette 410 is aligned with the reagent card on the fluorescence reading device 500, and then, the pipette 410 releases the final sample reagent, and the final sample reagent drips onto the reagent card, and finally the reagent card is read.

[0072] It should be noted that the sample purification and detection equipment 1000 of this embodiment can automatically complete the extraction step, nitrogen blowing and drying step, cleaning step and pipetting step. The whole process does not require manual operation, which can improve the efficiency of sample purification and detection.

[0073] In the description of the present invention, it should be understood that descriptions involving orientation, such as up, down, left, right, etc., indicating orientations or positional relationships, are based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention.

[0074] In the description of the utility model, if there is a description of first and second, it is only for the purpose of distinguishing the technical features, and cannot be understood as indicating or implying the relative importance or implicitly indicating the number of the indicated technical features or implicitly indicating the order of the indicated technical features.

[0075] In the description of the present invention, unless otherwise clearly defined, terms such as setting, installing, connecting, etc. should be understood in a broad sense, and technicians in the relevant technical field can reasonably determine the specific meanings of the above terms in the present invention based on the specific content of the technical solution.

[0076] Of course, the present invention is not limited to the above-mentioned embodiments, and technicians familiar with the field may make equivalent modifications or substitutions without violating the spirit of the present invention. These equivalent modifications or substitutions are all included in the scope defined by the claims of this application.

Claims

1. An extraction device, characterized in that include: An extraction component includes an extraction tube and a sample adding and pressurizing device, wherein the sample adding and pressurizing device includes an adapter and a plurality of output tubes, wherein the plurality of output tubes are passed through the adapter, wherein at least one of the output tubes is configured as a gas injection tube, and at least one of the output tubes is configured as a liquid injection tube, wherein a cavity is provided inside the extraction tube, and the extraction component has a combined state, wherein a partial structure of the adapter extends into the cavity and is sealed with the inner wall of the cavity, and the output tube is connected to the cavity.

2. The extraction device according to claim 1, characterized in that The sample adding and pressurizing device comprises a plurality of connecting tubes, and the plurality of connecting tubes correspond to the plurality of output tubes one by one. The upper ends of the output tubes are provided with connecting nozzles, and the connecting nozzles are connected to the connecting tubes.

3. The extraction device according to claim 1, characterized in that: The extraction tube is provided with a rib portion, and the extraction component has a separated state. In the separated state, the extraction tube is separated from the sample loading and pressurizing device. The extraction device also includes a tube-detaching component, and the tube-detaching component includes a tube-detaching frame, a first lifting mechanism and a horizontal telescopic mechanism. The first lifting mechanism is used to drive the sample loading and pressurizing device to perform lifting and lowering movements, and the horizontal telescopic mechanism is used to drive the tube-detaching frame to perform horizontal telescopic movements. When the tube-detaching frame extends above the rib portion and the first lifting mechanism lifts the sample loading and pressurizing device, the tube-detaching frame can abut against the rib portion to switch the extraction component from the combined state to the separated state.

4. The extraction device according to claim 3, characterized in that: The extraction device also includes a bottom plate and a support frame, the support frame is arranged on the bottom plate, the horizontal telescopic mechanism is arranged on the support frame, the horizontal telescopic mechanism is located below the first lifting mechanism, and the support frame is provided with an avoidance space for avoiding the tube removal frame.

5. The extraction device according to claim 3, characterized in that: The tube removal assembly also includes a first limiting device and / or a second limiting device, wherein the first limiting device is used to limit the range of travel of the lifting and lowering movement of the sample adding and pressurizing device, and the second limiting device is used to limit the range of travel of the horizontal telescopic movement of the sample adding and pressurizing device.

6. Sample purification and detection equipment, characterized in that: Comprising the extraction device according to any one of claims 1 to 5.

7. The sample purification detection device according to claim 6, characterized in that: The sample purification detection equipment also includes a pipe transport device, a nitrogen blowing and drying device, a pipetting device and a fluorescence reading device. The pipe transport device includes a turntable, a rotating mechanism, a second lifting mechanism and a plurality of collecting tubes. The collecting tube is used to collect the reagent in the extraction tube. The plurality of collecting tubes and the plurality of extraction tubes are placed on the turntable and arranged along the circumference of the turntable. The rotating mechanism is used to drive the turntable to rotate. The second lifting mechanism is used to drive at least one of the collecting tubes to perform lifting and lowering movements. The nitrogen blowing and drying device is used to perform nitrogen blowing and drying on the collecting tube. The pipetting device includes a pipette and a swing arm mechanism. The pipette can absorb or release liquid. When the second lifting mechanism lifts the collecting tube, the pipette can extend into the collecting tube. The swing arm mechanism is used to drive the pipette to swing back and forth from the collecting tube to the fluorescence reading device.

8. The sample purification detection device according to claim 7, characterized in that: The nitrogen blowing drying device comprises a nitrogen blowing pipe, a third lifting mechanism, an air pump assembly and a nitrogen heating assembly. The third lifting mechanism is used to drive the nitrogen blowing pipe to do lifting and lowering movements. The air pump assembly can provide nitrogen to the nitrogen blowing pipe. The nitrogen heating assembly is connected between the nitrogen blowing pipe and the air pump assembly.

9. The sample purification detection device according to claim 8, characterized in that: The nitrogen blowing drying device further comprises a third limiting device, and the third limiting device is used to limit the travel range of the lifting movement of the nitrogen blowing tube.

10. The sample purification detection device according to claim 7, characterized in that: The sample purification and detection equipment also includes a machine platform and a machine cover. The extraction device, the pipe transport device, the nitrogen blowing and drying device, the liquid transfer device and the fluorescence reading device are all arranged on the top of the machine platform. The machine cover is located on the top of the machine platform and is rotatably connected to the machine platform to cover the extraction device, the pipe transport device, the nitrogen blowing and drying device, the liquid transfer device and the fluorescence reading device.

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