Chromatographic purification device for animal plasma

Abstract

The utility model relates to the technical field of plasma purification, in particular to a chromatographic purification device for animal plasma, which comprises a placement frame, a plurality of storage barrels arranged at the top end of the placement frame, an extrusion plate arranged in each storage barrel, an electric push rod arranged at one end of each extrusion plate, a feeding pipe arranged at the top end of each storage barrel, and a cover cylinder arranged at the top end of each feeding pipe. A flow meter is arranged outside the discharge pipe; the discharge pipe is connected with a conveying pipe; the conveying pipe is connected with an inlet pipe; the inlet pipe is connected with a device main body, a supporting plate is arranged at the bottom of the device main body, a plurality of limiting cylinders are arranged at the top end of the supporting plate, and a driving motor is arranged at the bottom end of the supporting plate; by utilizing the structure of the storage barrel, the extrusion plate, the electric push rod, the cover barrel, the air outlet pipe, the exhaust valve, the flow meter, the conveying pipe, the supporting plate and the limiting barrel, the problem that the purification effect is affected due to the fact that a gel column bed surface is easily damaged when a common chromatographic column is directly poured and charged through the top end is solved.

Description

Technical Field

[0001] The utility model relates to the technical field of plasma purification, in particular to a chromatography purification device for animal plasma. Background Art

[0002] Plasma is one of the components of blood, mainly composed of water, protein, electrolytes and metabolic waste. In clinical and biomedical research, specific proteins, metabolites and other components in plasma are of great significance. Therefore, the separation and purification of plasma is one of the important technologies in the biomedical field. Traditional methods for plasma separation and purification include centrifugation, precipitation, filtration and other methods. Although these methods are simple and easy to use, the separation effect is poor and it is easy to cause the loss and contamination of target components. With the development of chromatography technology, more and more researchers have begun to use chromatography to separate and purify plasma. Gel chromatography technology is a separation technology based on molecular size, also known as gel filtration or molecular sieve chromatography. The principle of this technology is to use the molecular sieving effect of particles with a porous network structure to separate the components according to the relative molecular mass of each component in the separated sample. Gel chromatography technology usually uses gels with different pore sizes as separation media to achieve the separation of molecules of different sizes.

[0003] Generally, the material is added by pouring directly from the top of the chromatography column. This method of adding material can easily damage the gel column bed surface, thus affecting the purification effect. At the same time, when the general chromatography column is working, the configured operating solutions need to be poured in one by one, which is inconvenient to operate.

[0004] Therefore, it is particularly important to design a chromatographic purification device for animal plasma to change the above technical defects and improve overall practicality. Utility Model Content

[0005] The utility model aims to provide a chromatography purification device for animal plasma to solve the problems raised in the above background technology.

[0006] In order to achieve the above purpose, the utility model provides the following technical solutions:

[0007] A chromatography purification device for animal plasma comprises a placement rack, a plurality of storage barrels are arranged on the top of the placement rack, an extrusion plate is arranged inside the storage barrel, an electric push rod is arranged at one end of the extrusion plate, a feeding pipe is arranged at the top of the storage barrel, a cover cylinder is arranged at the top of the feeding tube, an air outlet pipe is arranged at the top of the storage barrel, an exhaust valve is arranged outside the air outlet pipe, a discharge pipe is arranged at one end of the storage barrel, a flow meter is arranged outside the discharge pipe, the discharge pipe is connected to a delivery pipe, the delivery pipe is connected to an inlet pipe, the inlet pipe is connected to a device body, a support plate is arranged at the bottom of the device body, a plurality of limit cylinders are arranged at the top of the support plate, and a driving motor is arranged at the bottom of the support plate.

[0008] As a preferred solution of the utility model, a scale for observation is provided on the outside of the storage barrel, and a plurality of placement plates for placing articles are provided on the placement rack.

[0009] As a preferred solution of the utility model, the electric push rod is fixedly connected to the extrusion plate, and a circle of sealing strip is provided at the edge of the extrusion plate.

[0010] As a preferred solution of the utility model, a battery and a control panel are provided inside the placement rack, the control panel is electrically connected to the battery, and the control panel is electrically connected to the electric push rod, the exhaust valve, the flow meter, the drive motor, and the device body.

[0011] As a preferred solution of the utility model, threads are provided at both ends of the delivery pipe, the delivery pipe is respectively connected to the inlet pipe and the outlet pipe through threads, and the cover tube is connected to the feeding pipe through threads.

[0012] As a preferred solution of the utility model, the driving motor and the supporting plate are fixedly connected, and a rubber cushion is provided inside the limiting cylinder.

[0013] Compared with the prior art, the beneficial effects of the utility model are:

[0014] 1. In the utility model, a chromatography purification device for animal plasma is provided, and a structure of a storage barrel, an extrusion plate, an electric push rod, a cover cylinder, an air outlet pipe, an exhaust valve, a flow meter, a delivery pipe, a support plate, and a limit cylinder is utilized. A plurality of storage barrels are provided to place different raw materials, and then the pushing speed is controlled by the cooperation of the flow meter and the electric push rod, so that the control is more precise and damage caused by direct dumping of the materials is avoided. The problem that the general chromatography column is directly dumped and fed through the top, and such a feeding method easily damages the gel column bed surface, thereby affecting the purification effect, and at the same time, when the general chromatography column is working, the configured operating solutions need to be poured in one by one, which is inconvenient to operate. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 It is a structural diagram of the entire utility model;

[0016] Figure 2 It is a schematic diagram of the material storage barrel assembly of the utility model;

[0017] Figure 3 It is a structural schematic diagram of the limiting cylinder assembly of the utility model.

[0018] In the figure: 1. placement rack; 101. storage barrel; 102. extrusion plate; 103. electric push rod; 104. feeding pipe; 105. cover cylinder; 106. air outlet pipe; 107. exhaust valve; 108. discharge pipe; 109. flow meter; 110. delivery pipe; 2. inlet pipe; 201. device body; 202. support plate; 203. limit cylinder; 204. drive motor. DETAILED DESCRIPTION

[0019] The technical solutions in the embodiments of the utility model will be clearly and completely described below in conjunction with the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, rather than all of the embodiments. Based on the embodiments of the utility model, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the utility model.

[0020] In order to facilitate the understanding of the utility model, the utility model will be described more comprehensively with reference to the relevant drawings below. Several embodiments of the utility model are given. However, the utility model can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the disclosure of the utility model more thorough and comprehensive.

[0021] It should be noted that when an element is referred to as being "fixed to" another element, it may be directly on the other element or there may be a central element. When an element is considered to be "connected to" another element, it may be directly connected to the other element or there may be a central element at the same time. The terms "vertical", "horizontal", "left", "right" and similar expressions used herein are for illustrative purposes only.

[0022] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art in the technical field of the present invention. The terms used herein in the specification of the present invention are only for the purpose of describing specific embodiments and are not intended to limit the present invention. The term "and / or" used herein includes any and all combinations of one or more related listed items.

[0023] For examples, see Figure 1-3 , the utility model provides a technical solution:

[0024] A chromatography purification device for animal plasma comprises a placing rack 1, wherein a plurality of storage barrels 101 are arranged at the top of the placing rack 1, a squeezing plate 102 is arranged inside the storage barrel 101, an electric push rod 103 is arranged at one end of the squeezing plate 102, a feeding pipe 104 is arranged at the top of the storage barrel 101, a cover tube 105 is arranged at the top of the feeding pipe 104, an air outlet pipe 106 is arranged at the top of the storage barrel 101, an exhaust valve 107 is arranged outside the air outlet pipe 106, a discharge pipe 108 is arranged at one end of the storage barrel 101, a flow meter 109 is arranged outside the discharge pipe 108, the discharge pipe 108 is connected to a conveying pipe 110, the conveying pipe 110 is connected to an inlet pipe 2, the inlet pipe 2 is connected to a device body 201, a support plate 202 is arranged at the bottom of the device body 201, a plurality of limiting tubes 203 are arranged at the top of the support plate 202, a driving motor 204 is arranged at the bottom of the support plate 202, and a collection cup is placed on the bottom of the device body 201. The device is placed inside the limiting cylinder 203, and then the required raw materials are added to the storage barrel 101 through the feeding tube 104, and then the cover cylinder 105 is closed, and the device body 201, the electric push rod 103, and the flow meter 109 are started at the same time. At this time, the electric push rod 103 drives the extrusion plate 102 to push the internal raw materials through the discharge pipe 108 to be delivered to the device body 201, and the flow rate inside the discharge pipe 108 is monitored by the flow meter 109, so as to control the speed of the extrusion plate 102 through the control panel. After the device body 201 is completed, the device body 201 discharges the raw materials into the collection cup, and as the driving motor 204 rotates, the collection cup is collected in an orderly manner. After the storage barrel 101 is completed, the exhaust valve 107 can be started to recycle the electric push rod 103, remove the delivery pipe 110 for replacement, and clean the inside of the storage barrel 101 at the same time;

[0025] The outside of the storage barrel 101 is provided with a scale for observation, and the placement rack 1 is provided with a plurality of placement plates for placing articles, which is convenient for placing articles. The electric push rod 103 and the extrusion plate 102 are fixedly connected, and a circle of sealing strips is provided at the edge of the extrusion plate 102 to facilitate pushing raw materials. The inside of the placement rack 1 is provided with a battery and a control panel, and the control panel is electrically connected to the battery. The control panel is electrically connected to the electric push rod 103, the exhaust valve 107, the flow meter 109, the drive motor 204, and the device body 201 to facilitate opening and closing components. Threads are provided at both ends of the conveying pipe 110, and the conveying pipe 110 is respectively connected to the inlet pipe 2 and the outlet pipe 108 by threads. The cover tube 105 is connected to the feeding tube 104 by threads to facilitate adding raw materials. The drive motor 204 and the support plate 202 are fixedly connected, and a rubber cushion is provided inside the limiting tube 203 to facilitate clamping the collecting tool.

[0026] The working process of the utility model is as follows: when using the chromatographic purification device of animal plasma, first place the collection cup inside the limiting cylinder 203, then add the required raw materials into the storage barrel 101 through the feeding tube 104, and then close the cover cylinder 105, and at the same time start the device body 201, the electric push rod 103, and the flow meter 109. At this time, the electric push rod 103 drives the extrusion plate 102 to push the internal raw materials through the discharge pipe 108 to be delivered to the device body 201, and at the same time monitors the flow inside the discharge pipe 108 through the flow meter 109, so as to control the speed of the extrusion plate 102 through the control panel. After the work of the device body 201 is completed, the device body 201 discharges the raw materials into the collection cup, and as the driving motor 204 rotates, the collection cup is collected in an orderly manner. After the work of the storage barrel 101 is completed, the exhaust valve 107 can be started to recycle the electric push rod 103, remove the delivery pipe 110 for replacement, and clean the inside of the storage barrel 101 at the same time.

[0027] The electric push rod 102, exhaust valve 107, flow meter 109, device body 201, and drive motor 204 used in the utility model are existing known electrical equipment and can be directly purchased and used on the market. Their structures, circuits, and control principles are all existing known technologies. Therefore, the structures, circuits, and control principles of the electric push rod 102, exhaust valve 107, flow meter 109, device body 201, and drive motor 204 are not described in detail here.

[0028] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A chromatographic purification device for animal plasma, comprising a rack (1), characterized in that: A plurality of material storage barrels (101) are provided at the top of the placement rack (1), an extrusion plate (102) is provided inside the material storage barrel (101), an electric push rod (103) is provided at one end of the extrusion plate (102), a feeding pipe (104) is provided at the top of the material storage barrel (101), a cover tube (105) is provided at the top of the feeding pipe (104), an air outlet pipe (106) is provided at the top of the material storage barrel (101), an exhaust valve (107) is provided outside the air outlet pipe (106), and the material storage barrel (101) is provided with a plurality of material storage barrels (101), an extrusion plate (102) is provided inside the material storage barrel (101), an electric push rod (103) is provided at one end of the extrusion plate (102), a feeding pipe (104) is provided at the top of the feeding pipe (104), an air outlet pipe (106) is provided at the top of the material storage barrel (101), an exhaust valve (107) is provided outside the air outlet pipe (106), and the material storage barrel (101) is provided with a plurality of material storage barrels (101). A discharge pipe (108) is provided at one end of the device (101), a flow meter (109) is provided outside the discharge pipe (108), the discharge pipe (108) is connected to a delivery pipe (110), the delivery pipe (110) is connected to an inlet pipe (2), the inlet pipe (2) is connected to a device body (201), a support plate (202) is provided at the bottom of the device body (201), a plurality of limit cylinders (203) are provided at the top of the support plate (202), and a driving motor (204) is provided at the bottom of the support plate (202).

2. The chromatographic purification device for animal plasma according to claim 1, characterized in that: The outside of the material storage barrel (101) is provided with a scale for observation, and the placement rack (1) is provided with a plurality of placement plates for placing items.

3. The chromatographic purification device for animal plasma according to claim 1, characterized in that: The electric push rod (103) and the extrusion plate (102) are fixedly connected, and a circle of sealing strip is provided at the edge of the extrusion plate (102).

4. The chromatographic purification device for animal plasma according to claim 1, characterized in that: A storage battery and a control panel are provided inside the placement rack (1); the control panel is electrically connected to the storage battery; and the control panel is electrically connected to the electric push rod (103), the exhaust valve (107), the flow meter (109), the drive motor (204), and the device body (201).

5. The chromatographic purification device for animal plasma according to claim 1, characterized in that: Both ends of the delivery pipe (110) are provided with threads, and the delivery pipe (110) is respectively connected to the inlet pipe (2) and the outlet pipe (108) through threads, and the cover tube (105) is connected to the feeding pipe (104) through threads.

6. The chromatographic purification device for animal plasma according to claim 1, characterized in that: The driving motor (204) and the supporting plate (202) are fixedly connected, and a rubber cushion is provided inside the limiting cylinder (203).

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