Cell subpackaging system

Abstract

The utility model discloses a cell subpackaging system which comprises a machine table, a cell bag shaking-up assembly, a liquid separating and supplying assembly, a consumable conveying assembly, a filling assembly, a heat sealing and cutting assembly and a finished product conveying assembly. The cell bag shaking-up assembly is arranged on the machine table, and a cell mixing bag for filling and supplying is arranged in the cell bag shaking-up assembly; the consumable conveying assembly is arranged on one side of the cell bag shaking-up assembly, a plurality of consumable bag bodies used for receiving filling are arranged in the consumable conveying assembly, the consumable bag bodies are sequentially arranged, and the consumable conveying assembly is used for sequentially conveying the consumable bag bodies to the filling position; each consumable bag body comprises a consumable bag liquid distribution head, a plurality of heat sealing pipelines and a plurality of disposable sterile bags, and each consumable bag liquid distribution head is provided with a plurality of liquid distribution branches. Through the arrangement, cell sap can be sub-packaged into the consumable bag body in batches, and the sub-packaging speed of equipment is improved.

Description

Technical Field

[0001] The utility model relates to the field of cell preparation, in particular to a cell packaging system. Background Art

[0002] In the preparation process of cell products, it is often necessary to centrifuge the cells, mix the centrifuged cells with the cryopreservation solution and package them. There are currently two main ways to package cells, one is packaging in disposable cryopreservation bags, and the other is packaging in traditional vials. Compared with vials, cryopreservation bags can quickly remove cells from cryopreservation bags after the cells are thawed, while vials need to be completely thawed before they can be taken out and collected. Therefore, cell packaging in cryopreservation bags has a greater advantage. However, most of the current cell cryopreservation bag packaging technologies are small-throughput filling, and they need to be taken manually after filling, and the efficiency of cell packaging is low.

[0003] Therefore, a cell packaging system is needed to perform filling and packaging in batches to improve cell packaging efficiency. Utility Model Content

[0004] The utility model aims to provide a cell packaging system, which can perform filling and packaging in batches and improve the packaging rate of the equipment.

[0005] In order to solve the above technical problems, the utility model provides a cell packaging system, including: a machine, a cell bag shaking component, a liquid distribution supply component, a consumable material conveying component, a filling component, a heat sealing and cutting component and a finished product conveying component;

[0006] The cell bag shaking component is arranged on the machine platform, and the cell bag shaking component is built with a cell mixing bag for filling supply;

[0007] The consumables conveying assembly is arranged on one side of the cell bag shaking assembly, and is equipped with a plurality of consumables package bodies for receiving filling, the consumables package bodies are arranged in sequence, and the consumables conveying assembly is used to convey the consumables package bodies to the filling positions in sequence, each of the consumables package bodies comprises a consumables package dispensing head, a plurality of heat-sealed pipelines and a plurality of disposable sterile bags, the consumables package dispensing head has a plurality of dispensing branches, and the plurality of dispensing branches are connected one by one with the plurality of disposable sterile bags through corresponding heat-sealed pipelines;

[0008] The liquid dispensing supply assembly is arranged on the machine platform, and one end of the assembly is connected to the liquid outlet pipeline of the cell mixing bag, and the other end is provided with a plurality of liquid dispensing pipelines, and the plurality of liquid dispensing pipelines are connected to the plurality of liquid dispensing heads of the consumable package bodies in a one-to-one correspondence;

[0009] The filling assembly is located in front of the consumables conveying assembly and is used for filling the consumables package body;

[0010] The heat sealing and cutting assembly is arranged on the side wall of the machine platform and is used for heat sealing and cutting of the consumable package body to achieve sealing and separation of a plurality of disposable sterile bags;

[0011] The finished product conveying assembly is arranged below the filling assembly and is used for carrying and conveying a plurality of the disposable sterile bags.

[0012] Furthermore, the liquid separation supply assembly includes a fixed frame, a sterile storage bag, a plurality of liquid separation pipelines and a plurality of liquid separation pinch valves, the sterile storage bag is fixed on the fixed frame, the input end of the sterile storage bag is connected to the liquid outlet pipeline of the cell mixing bag, one end of the plurality of liquid separation pipelines is connected to the output end of the sterile storage bag, the other ends of the plurality of liquid separation pipelines are also provided with sterile connectors, the sterile connectors on the liquid separation pipelines are used to connect to the sterile connectors of the consumable package body, the plurality of liquid separation pinch valves are arranged one-to-one with the plurality of liquid separation pipelines, and each liquid separation pinch valve is used to control the on-off of the corresponding liquid separation pipeline.

[0013] Further, the consumable material conveying assembly includes: a first conveyor belt unit and a plurality of consumable material loading boxes;

[0014] The first conveyor belt unit is disposed on the machine platform and is used to convey materials in a front-to-back direction;

[0015] A plurality of the consumable loading boxes are sequentially arranged on the first conveyor belt unit, and the consumable loading boxes are arranged in one-to-one correspondence with the consumable package body, and each consumable loading box has a plurality of accommodating spaces for placing disposable sterile bags.

[0016] Furthermore, the consumable material conveying assembly further includes: a consumable material pushing cylinder, a consumable material lifting cylinder, a baffle and a consumable material support frame;

[0017] The baffle is arranged at the front end of the first conveyor belt unit and is used for limiting the position of the consumable material loading box;

[0018] The consumable lifting cylinder and the consumable pushing cylinder are both arranged on the machine platform, the consumable lifting cylinder is used to lift the consumable loading box and make it exceed the height of the baffle, the edge of the machine platform has a notch, the outer dimensions of the notch are set according to the outer dimensions of the consumable loading box, and the consumable pushing cylinder is used to push the consumable loading box and move it to just above the notch;

[0019] The consumable support frame includes two symmetrically arranged support structures, the bottom of the support structure is fixed on the machine platform, the tops of the two support structures have a preset gap, and the consumable package dispensing heads of the multiple consumable package bodies are all arranged in the preset gap and can move back and forth along the preset gap.

[0020] Further, the finished product conveying assembly includes a second conveyor belt unit, which is fixed to the side wall of the machine platform and is used to convey materials in the left and right directions;

[0021] The second conveyor belt unit includes a frame and two conveyor belt assemblies. The two conveyor belt assemblies are respectively arranged on both sides of the inner wall of the frame, and a gap is reserved between them.

[0022] Furthermore, the consumable material conveying assembly also includes a consumable material receiving unit and a consumable material fixing unit;

[0023] The consumables receiving unit includes a lifting drive mechanism and a lifting support plate, wherein the lifting drive mechanism is installed on the side wall of the machine platform, the lifting support plate is connected to the moving end of the lifting drive mechanism, the lifting support plate can pass through the gap between the two conveyor belt assemblies, and the lifting support plate is equipped with a vacuum suction cup, which is used to absorb the consumables loading box;

[0024] The consumable fixing unit includes a bracket, an inner clamping cylinder, two outer clamping cylinders and two consumable fixing cylinders. The inner clamping cylinder, the two outer clamping cylinders and the two consumable fixing cylinders are all installed on the bracket, and the inner clamping cylinder is located between the two outer clamping cylinders, the outer clamping cylinder is located between the two consumable fixing cylinders, and the bracket is fixed on the side wall of the machine.

[0025] Further, the heat sealing and cutting assembly includes: a positioning heating plate and a sliding cutting plate;

[0026] The positioning heating plate is fixedly mounted on the side wall of the machine platform through a bracket;

[0027] The sliding cutting plate is slidably mounted inside the machine platform and can move toward the positioning heating plate to clamp and cut the heat-sealed pipeline of the consumable package body.

[0028] Furthermore, a spring seat is provided on one side of the sliding cutting plate close to the positioning heating plate;

[0029] When the sliding cutting plate moves in a direction close to the positioning heating plate and contacts the heat sealing pipeline of the consumable package body and the positioning heating plate, the spring seat can shrink to expose the cutting knife on the sliding cutting plate for cutting the consumable package body.

[0030] Further, the filling assembly includes: a multi-channel peristaltic pump and an exhaust pinch valve;

[0031] The multiple heat-sealed pipelines of the consumables package body are all clamped in the multi-channel peristaltic pump, and the multi-channel peristaltic pump is used to simultaneously pump the liquid in the liquid separation pipeline to each disposable sterile bag of the consumables package body;

[0032] The exhaust pinch valve is arranged on the exhaust pipe of the consumable package body and is used to control the on-off of the exhaust pipe.

[0033] Further, the filling assembly also includes: a liquid level sensor and a sensor displacement cylinder;

[0034] The sensor displacement cylinder is fixedly mounted on the side wall of the machine platform through a bracket, the liquid level sensor is connected to the moving end of the sensor displacement cylinder, and the liquid level sensor is used to sense the liquid level in the disposable sterile bag.

[0035] Furthermore, the liquid separation supply component, the consumables conveying component, the filling component and the heat sealing and cutting component are each provided with two groups, and are respectively located on both sides of the cell bag shaking component.

[0036] Furthermore, the cell bag shaking component is a wave-type bioreactor or an extrusion-type mixing device.

[0037] Furthermore, the machine platform is also provided with a support frame, a liquid inlet peristaltic pump and a liquid outlet peristaltic pump;

[0038] A plurality of sterile containers are hung on the support frame, and the plurality of sterile containers are used to store cell fluid, freezing fluid and culture medium respectively;

[0039] The liquid outlet end of the sterile container is connected to the liquid inlet pipeline of the cell mixing bag through a sterile joint, and the liquid inlet peristaltic pump is arranged on the liquid inlet pipeline to pump any one of the cell fluid, freezing solution and culture medium or any combination thereof into the cell mixing bag;

[0040] The liquid outlet peristaltic pump is arranged on the liquid outlet pipeline of the cell mixing bag, and is used to pump the liquid in the cell mixing bag into the sterile storage bag of the liquid separation supply assembly.

[0041] Furthermore, it also includes a control unit, and the liquid inlet peristaltic pump, the liquid outlet peristaltic pump, the cell bag shaking assembly, the liquid separation supply assembly, the consumable material conveying assembly, the filling assembly, the heat sealing and cutting assembly, and the finished product conveying assembly are all electrically connected to the control unit.

[0042] Compared with the prior art, the utility model has at least the following beneficial effects:

[0043] By setting up a cell bag shaking component, a liquid dispensing supply component, a consumable material conveying component, a filling component, a finished product conveying component and a heat sealing and cutting component that can shake the cell mixing bag, and connecting the cell mixing bag to the liquid dispensing head of the liquid dispensing supply component and connecting the liquid dispensing head to the consumable package body on the consumable material conveying component, it is convenient to subsequently fill the cell fluid in the cell mixing bag into the consumable package body. Therefore, when the consumable material conveying component conveys multiple consumable package bodies one by one, it can cooperate with the filling component, the finished product conveying component and the heat sealing and cutting component to complete the filling, heat sealing and conveying of the cell fluid in the consumable package body, thereby achieving the purpose of batch filling, thereby effectively improving the rate of cell fluid filling. BRIEF DESCRIPTION OF THE DRAWINGS

[0044] Figure 1 This is a front view of the cell packaging system of the utility model;

[0045] Figure 2 It is a structural schematic diagram of the cell packaging system of the utility model;

[0046] Figure 3 It is a top view of the cell packaging system of the utility model;

[0047] Figure 4 A front view of the liquid dispensing supply assembly in the cell dispensing system of the utility model;

[0048] Figure 5 This is a schematic diagram of the structure of the consumables package body in the cell packaging system of the utility model;

[0049] Figure 6 It is a structural side view of the consumables conveying component in the cell dispensing system of the utility model;

[0050] Figure 7 It is a schematic diagram of the local structure of the notch in the cell packaging system of the utility model;

[0051] Figure 8 It is a partial structural schematic diagram of the cell packaging system of the utility model when the consumable package body is placed on the finished product conveying component;

[0052] Fig. 9 It is a partial structural schematic diagram of the finished product conveying component in the cell packaging system of the utility model;

[0053] Fig.10 This is a schematic diagram of the structure of the heat-sealing and cutting components in the cell packaging system of the utility model;

[0054] Fig.11It is a schematic diagram of the structure before and after the consumable package body contacts the liquid outlet peristaltic pump in the cell dispensing system of the utility model;

[0055] Fig.12 This is a schematic structural diagram from another perspective of the consumable package body in the cell packaging system of the utility model.

[0056] Figure Number:

[0057] 1. Machine;

[0058] 2. Shake the cell bag assembly;

[0059] 3. Liquid dispensing supply assembly; 31. Liquid dispensing pipeline; 32. Fixed frame; 33. Sterile storage bag;

[0060] 4. Consumables conveying assembly; 41. Consumables loading box; 421. Consumables pushing cylinder; 422. Consumables lifting cylinder; 43. Baffle; 431. Lifting drive mechanism; 432. Vacuum suction cup; 44. Consumables support frame; 451. Consumables fixing cylinder 1; 452. Consumables fixing cylinder 2; 453. Outer clamping cylinder 1; 454. Outer clamping cylinder 2; 455. Inner clamping cylinder;

[0061] 5. Filling assembly; 53. Liquid level sensor; 54. Sensor displacement cylinder;

[0062] 6. Finished product conveying assembly; 61. Frame; 62. Conveyor belt assembly;

[0063] 7. Heat sealing cutting assembly; 71. Heating plate; 72. Sliding cutting plate; 721. Spring seat;

[0064] 8. Notch; 81. Disposable sterile bag; 82. Heat-sealed pipeline; 83. Dispensing head for consumable package; 84. Butterfly filter; 85. Sterile connector;

[0065] 9. Horizontal board;

[0066] 10. Lifting pallet;

[0067] 11. Support frame. DETAILED DESCRIPTION

[0068] The cell packaging system of the present invention will be described in more detail below in conjunction with the schematic diagram, wherein the preferred embodiment of the present invention is shown, and it should be understood that those skilled in the art can modify the present invention described herein, while still achieving the advantageous effects of the present invention. Therefore, the following description should be understood as being widely known to those skilled in the art, and not as a limitation to the present invention.

[0069] The present invention is described in more detail in the following paragraphs by way of example with reference to the accompanying drawings. The advantages and features of the present invention will become more apparent from the following description. It should be noted that the accompanying drawings are in very simplified form and in non-precise proportions, and are only used to conveniently and clearly assist in explaining the purpose of the embodiments of the present invention.

[0070] Embodiment 1

[0071] like Figures 1 to 5 As shown, the embodiment of the utility model proposes a cell packaging system, including: a machine 1, a cell bag shaking component 2, a liquid distribution supply component 3, a consumable material conveying component 4, a filling component 5, a heat sealing and cutting component 7 and a finished product conveying component 6;

[0072] The cell bag shaking component 2 is arranged on the machine 1, and the cell bag shaking component 2 is built with a cell mixing bag for filling supply;

[0073] The consumable conveying component 4 is arranged on one side of the cell bag shaking component 2 and has a plurality of consumable package bodies for receiving filling. The consumable package bodies are arranged in sequence, and the consumable conveying component 4 is used to convey the consumable package bodies to the filling positions in sequence.

[0074] like Figure 5 As shown, each of the consumable package bodies includes a consumable package dispensing head 83, multiple heat-sealing pipes 82 and multiple disposable sterile bags 81. The consumable package dispensing head 83 has multiple dispensing branches, and the multiple dispensing branches are connected one-to-one with the multiple disposable sterile bags 81 through corresponding heat-sealing pipes 82 to meet the needs of subsequent batch filling.

[0075] In addition, the consumable package body also includes a butterfly filter 84, which is arranged between the consumable package dispensing head 83 and the sterile connecting head 85 to ensure the filling quality.

[0076] The liquid separation supply component 3 is arranged on the machine 1, and one end of it is connected to the liquid outlet pipeline of the cell mixing bag, and the other end is provided with multiple liquid separation pipelines 31, and the multiple liquid separation pipelines 31 are connected one by one with the consumable package liquid separation heads 83 of the multiple consumable package bodies.

[0077] It should be noted that when filling is performed, the consumable package dispensing head 83 located at the filling position is docked with the sterile connector 85 (not shown in the figure) of one of the dispensing pipelines 31, that is, the two sterile connectors 85 are docked to further improve the filling quality.

[0078] The filling assembly 5 is located in front of the consumables conveying assembly 4 and is used for filling the consumables package body.

[0079] The heat sealing and cutting assembly 7 is disposed on the side wall of the machine 1 and is used for heat sealing and cutting the consumable package body to achieve sealing and separation of the plurality of disposable sterile bags 81 , so that the subsequent finished product conveying assembly 6 can convey the separated plurality of disposable sterile bags 81 .

[0080] The finished product conveying assembly 6 is disposed below the filling assembly 5 and is used for carrying and conveying a plurality of the disposable sterile bags 81 .

[0081] The device is provided with a cell bag shaking component 2, a liquid separation supply component 3, a consumable material conveying component 4, a filling component 5, a finished product conveying component 6 and a heat sealing and cutting component 7, which can shake the cell mixing bag, and one end of the liquid separation supply component 3 is connected to the liquid outlet pipeline of the cell mixing bag, and the other end is correspondingly connected to the consumable bag liquid separation head 83 of the consumable bag body through the liquid separation pipeline 31, so as to facilitate the filling of the cell fluid in the cell mixing bag into the consumable bag body. Therefore, when the consumable material conveying component 4 conveys multiple consumable bag bodies one by one, it can cooperate with the filling component 5, the finished product conveying component 6 and the heat sealing and cutting component 7 to complete the filling of the cell fluid in the disposable sterile bag 81, the heat sealing separation of the disposable sterile bag 81 and the conveying of the disposable sterile bag 81 after filling, so as to achieve the purpose of batch filling, thereby effectively improving the rate of cell fluid filling.

[0082] Please continue reading Figure 4 In a further embodiment, the liquid separation supply component 3 is further limited to better supply the cell fluid.

[0083] Specifically, the liquid separation supply assembly 3 includes a fixing frame 32, a sterile storage bag 33, a plurality of liquid separation pipelines 31 and a plurality of liquid separation pinch valves.

[0084] Among them, the sterile storage bag 33 is fixed on the fixing frame 32, the input end of the sterile storage bag 33 is connected to the liquid outlet pipeline of the cell mixing bag, one end of the multiple liquid separation pipelines 31 is connected to the output end of the sterile storage bag 33, and the other ends of the multiple liquid separation pipelines 31 are also provided with sterile connectors 85, and the sterile connectors 85 on the liquid separation pipelines 31 are used to connect to the sterile connectors 85 of the consumable package body. The multiple liquid separation clamping valves are arranged one by one with the multiple liquid separation pipelines 31, and each liquid separation clamping valve is used to control the opening and closing of the corresponding liquid separation pipeline 31, so that when the consumable package body is transported to the designated position, the liquid separation supply component 3 can designate the consumable package body at that position to supply cell fluid.

[0085] like Figures 5 to 7 As shown, in other embodiments, the consumable material conveying component 4 is further limited to improve the conveying effect of the consumable material package body.

[0086] Specifically, the consumable material conveying assembly 4 includes a first conveyor belt unit and a plurality of consumable material loading boxes 41 .

[0087] The first conveyor belt unit is disposed on the machine platform 1 and is used to convey materials along the front-rear direction.

[0088] The plurality of consumable loading boxes 41 are sequentially arranged on the first conveyor belt unit. The consumable loading boxes 41 are arranged in one-to-one correspondence with the consumable package body. Each consumable loading box 41 has a plurality of accommodating spaces for placing disposable sterile bags 81 .

[0089] Please continue reading Figure 7 The consumable material conveying assembly 4 also includes a consumable material pushing cylinder 421, a consumable material lifting cylinder 422, a baffle 43 and a consumable material supporting frame 44.

[0090] The baffle 43 is disposed at the front end of the first conveyor belt unit and is used to limit the position of the consumables loading box 41 .

[0091] The consumable lifting cylinder 422 and the consumable pushing cylinder 421 are both arranged on the machine 1. The consumable lifting cylinder 422 is used to lift the consumable loading box 41 and make it exceed the height of the baffle 43. The edge of the machine 1 has a notch 8, and the outer dimensions of the notch 8 are set according to the outer dimensions of the consumable loading box 41. The consumable pushing cylinder 421 is used to push the consumable loading box 41 and move it to directly above the notch 8.

[0092] Preferably, the consumable support frame 44 includes two symmetrically arranged support structures, the bottom of the support structure is fixed on the machine 1, and the tops of the two support structures have a preset gap. The consumable pack dispensing heads 83 of the multiple consumable pack bodies are all arranged in the preset gap and can move back and forth along the preset gap, ensuring that the consumable pack dispensing heads 83 will not cause interference during operation.

[0093] like Figure 8 and Fig. 9 As shown, in other embodiments, the finished product conveying assembly 6 is further limited to facilitate the conveying of the consumables after filling.

[0094] The finished product conveying assembly 6 includes a second conveyor belt unit, which is fixed on the side wall of the machine platform 1 and is used to convey materials in the left and right directions.

[0095] Please continue reading Fig. 9The second conveyor belt unit includes a frame 61 and two conveyor belt assemblies 62. The two conveyor belt assemblies 62 are respectively arranged on both sides of the inner wall of the frame 61, and a gap is reserved between them to facilitate placing consumables on the frame 61 through the consumable conveying assembly 4.

[0096] Please continue reading Figure 7 , Fig.11 as well as Fig.12 As shown, the consumable material conveying assembly 4 also includes a consumable material receiving unit and a consumable material fixing unit.

[0097] The consumable material receiving unit includes a lifting drive mechanism 431 and a lifting support plate 10 .

[0098] Among them, the lifting drive mechanism 431 is installed on the side wall of the machine 1, the lifting pallet 10 is connected to the moving end of the lifting drive mechanism 431, the lifting pallet 10 can pass through the gap between the two conveyor belt assemblies 62, and the lifting pallet 10 is equipped with a vacuum suction cup 432, and the vacuum suction cup 432 is used to adsorb the consumable loading box 41.

[0099] The consumable fixing unit includes a bracket, an inner clamping cylinder 455, two outer clamping cylinders (such as outer clamping cylinder one 453 and outer clamping cylinder two 454) and two consumable fixing cylinders (such as consumable fixing cylinder one 451 and consumable fixing cylinder two 452), the inner clamping cylinder 455, the two outer clamping cylinders and the two consumable fixing cylinders are all installed on the bracket, and the inner clamping cylinder 455 is located between the two outer clamping cylinders, the outer clamping cylinder is located between the two consumable fixing cylinders, and the bracket is fixed on the side wall of the machine 1.

[0100] like Fig.10 As shown, in a further embodiment, a specific heat-sealing cutting assembly 7 is also provided to enhance the heat-sealing separation effect of the disposable sterile bag 81 .

[0101] Specifically, the heat sealing and cutting assembly 7 includes a positioning heating plate 71 and a sliding cutting plate 72 .

[0102] The positioning heating plate 71 is fixedly mounted on the side wall of the machine platform 1 through a bracket.

[0103] The sliding cutting plate 72 is slidably installed inside the machine 1 and can move toward the positioning heating plate 71 to clamp and cut the heat-sealing pipeline 82 of the consumable package body.

[0104] In addition, a spring seat 721 is provided on one side of the sliding cutting plate 72 close to the positioning heating plate 71 .

[0105] When the sliding cutting plate 72 moves in a direction close to the positioning heating plate 71 and contacts the heat sealing pipeline 82 of the consumable package body and the positioning heating plate 71, the spring seat 721 can shrink to expose the cutting knife on the sliding cutting plate 72 for cutting the consumable package body.

[0106] Please continue reading Figure 8 In a further embodiment, the filling component 5 is further limited to improve the filling effect and filling rate of the cell fluid.

[0107] Specifically, the filling assembly 5 includes a multi-channel peristaltic pump and an exhaust pinch valve.

[0108] The multiple heat-sealed pipelines 82 of the consumable package body are all clamped in the multi-channel peristaltic pump, and the multi-channel peristaltic pump is used to simultaneously pump the liquid in the liquid separation pipeline 31 to each disposable sterile bag 81 of the consumable package body.

[0109] It should be noted that a horizontal plate 9 is provided outside the notch 8 of the machine 1, the multi-channel peristaltic pump is installed on the horizontal plate 9, and the number of channels of the multi-channel peristaltic pump is set according to the number of disposable sterile bags 81 of the consumable package body.

[0110] It should also be noted that, in the present embodiment, the multi-channel peristaltic pump is configured as a 12-channel peristaltic pump, and accordingly, each consumable package body includes 12 disposable sterile bags 81 , corresponding to 12 heat-sealed pipelines 82 .

[0111] Therefore, in this embodiment, each consumable conveying component 4 has 13 consumable package bodies built in, so 13*12 (bags) can be packed at the same time, and because of the settings on the left and right sides, 13*12*2 (bags) can be packed at the same time. The system meets the requirements of packing more than 300 bags at a time.

[0112] The exhaust pinch valve is arranged on the exhaust pipe of the consumable package body and is used to control the on-off of the exhaust pipe.

[0113] In a further embodiment, the filling assembly 5 further includes a liquid level sensor 53 and a sensor displacement cylinder 54 .

[0114] The sensor displacement cylinder 54 is fixedly mounted on the side wall of the machine platform 1 through a bracket, and the liquid level sensor 53 is connected to the moving end of the sensor displacement cylinder 54 . The liquid level sensor 53 is used to sense the liquid level in the disposable sterile bag 81 .

[0115] The liquid separation supply component 3, the consumables conveying component 4, the filling component 5 and the heat sealing and cutting component 7 are each provided with two groups, and are respectively located on both sides of the cell bag shaking component 2 to achieve simultaneous filling on both sides, thereby meeting the needs of large-scale filling.

[0116] It should be particularly pointed out that the five cylinders of the consumable fixing unit, the sensor displacement cylinder 54 and the positioning heating plate 71 are all connected to the same bracket, so as to effectively reduce the space occupied by the equipment and improve space utilization.

[0117] In this embodiment, the cell bag shaking component 2 is also limited. Specifically, the cell bag shaking component 2 is a wave-type bioreactor or an extrusion-type mixing device, that is, the cell mixing bag is shaken or squeezed to achieve the purpose of cell mixing and ensure the uniformity of cell packaging.

[0118] Preferably, the machine 1 is also provided with a support frame 11, a liquid inlet peristaltic pump and a liquid outlet peristaltic pump.

[0119] A plurality of sterile containers are hung on the support frame 11, and the plurality of sterile containers are used to store cell fluid, freezing fluid and culture medium respectively.

[0120] The liquid outlet of the sterile container is connected to the liquid inlet pipeline of the cell mixing bag through a sterile joint, and the liquid inlet peristaltic pump is arranged on the liquid inlet pipeline to pump any one of the cell fluid, freezing solution and culture medium or any combination thereof into the cell mixing bag;

[0121] The liquid outlet peristaltic pump is arranged on the liquid outlet pipeline of the cell mixing bag, and is used to pump the liquid in the cell mixing bag into the sterile storage bag 33 of the liquid separation supply component 3.

[0122] In other embodiments, the cell packaging system also includes a control unit, and the liquid inlet peristaltic pump, the liquid outlet peristaltic pump, the cell bag shaking assembly 2, the liquid separation supply assembly 3, the consumable material conveying assembly 4, the filling assembly 5, the heat sealing and cutting assembly 7, and the finished product conveying assembly 6 are all electrically connected to the control unit to facilitate the coordinated operation of the various components.

[0123] Embodiment 2

[0124] On the other hand, the utility model also proposes a cell packaging method, which adopts the cell packaging system described in Example 1, so that all components work according to the control instructions of the control unit, and can automatically perform packaging according to the preset total packaging amount and the packaging amount of a single disposable sterile bag 81.

[0125] And includes the following technical steps:

[0126] Pumping any one or any combination of cell solution, culture medium and freezing solution into the cell mixing bag through a liquid inlet peristaltic pump;

[0127] The liquid in the cell mixing bag is mixed by the cell bag shaking component 2, and the process parameters (such as oxygen, carbon dioxide and temperature, etc.) in the cell mixing bag are controlled;

[0128] The liquid in the cell mixing bag is pumped into the sterile storage bag 33 of the liquid dispensing supply assembly 3 by the liquid outlet peristaltic pump;

[0129] The consumables conveying assembly 4 sequentially conveys the multiple consumables package bodies to the filling position, and performs cell packaging sequentially;

[0130] The cell packaging process of each consumable package includes:

[0131] The liquid in the sterile storage bag is pumped into each disposable sterile bag 81 of the consumables package body through the filling component 5;

[0132] Heat-seal and cut the consumables package body by the heat-seal cutting assembly 7 to achieve sealing and separation of the plurality of disposable sterile bags 81; and

[0133] The multiple disposable sterile bags 81 are carried and conveyed by the finished product conveying component 6, that is, conveyed to the downstream production line for subsequent production and packaging.

[0134] It should be particularly noted that before the consumables conveying assembly 4 sequentially conveys the multiple consumables package bodies to the filling position and sequentially performs cell packaging, the process also includes:

[0135] Place multiple consumable loading boxes 41 containing consumable pack bodies on the first conveyor belt unit of the consumable conveying assembly 4 in sequence, and hang the consumable pack dispensing heads 83 of the consumable pack bodies on the consumable support frame 44 of the consumable conveying assembly 4 in sequence;

[0136] The plurality of consumable package bodies are connected to the plurality of liquid separation pipelines 31 of the liquid separation supply assembly 3 in a one-to-one correspondence, specifically, they are connected one by one manually.

[0137] Furthermore, the process of pumping the liquid in the sterile storage bag into each disposable sterile bag 81 of the consumables package body by the filling component 5 includes:

[0138] The consumable lifting cylinder 422 lifts a consumable loading box 41 at the front end of the first conveyor unit, and then the consumable pushing cylinder 421 pushes the consumable loading box 41 and transfers it to the top of the consumable receiving unit. During this process, the lifting drive mechanism 431 of the consumable receiving unit drives the lifting support plate 10 to rise, and the lifting support plate 10 absorbs the consumable loading box 41 through the vacuum suction cup 432;

[0139] The lifting drive mechanism 431 drives the lifting support plate 10 to descend until the consumable package body in the consumable loading box 41 is located at the heat sealing cutting position;

[0140] The consumable fixing cylinder of the consumable fixing unit extends out of the moving end and is inserted between the heat sealing pipelines 82 of the consumable package body;

[0141] It should be noted that when the horizontal pipeline above the heat-sealing pipeline 82 is blocked by the consumable fixing cylinder and cannot continue to move downward, the lifting support plate 10 continues to descend until the heat-sealing pipeline 82 is straightened.

[0142] The lifting drive mechanism 431 drives the lifting support plate 10 to continue to descend until the consumable package body in the consumable loading box 41 is located at the filling position. At this time, the consumable loading box 41 is placed on the second conveyor belt unit of the finished product conveying assembly 6;

[0143] The multiple heat-sealed pipelines 82 of the consumable package body are all clamped in a multi-channel peristaltic pump;

[0144] Clamp two of the liquid dispensing branches of the consumables package body in the first exhaust pinch valve and the second exhaust pinch valve respectively;

[0145] It should be pointed out that the above clamping is all performed manually.

[0146] Open the first exhaust pinch valve, close the second exhaust pinch valve, and open the liquid separation pinch valve at the same time, and perform the first exhaust through the multi-channel peristaltic pump until liquid appears in the heat-sealed pipeline 82 of the consumable package body;

[0147] Close the first exhaust pinch valve, open the second exhaust pinch valve, and simultaneously pump the liquid in the sterile storage bag into the multiple disposable sterile bags 81 of the consumables package body through the multi-channel peristaltic pump;

[0148] The first exhaust pinch valve is opened, the liquid separation pinch valve is closed, and the multi-channel peristaltic pump is reversed to perform the second exhaust;

[0149] When the liquid level sensor 53 detects that the liquid level in the disposable sterile bag 81 reaches a predetermined height, the multi-channel peristaltic pump stops working and simultaneously closes the second exhaust pinch valve to end exhaust.

[0150] Furthermore, the process of heat-sealing and cutting the consumable package body by the heat-sealing and cutting assembly 7 to seal and separate the plurality of disposable sterile bags 81 includes:

[0151] The positioning heating plate 71 of the heat sealing and cutting assembly 7 is heated up;

[0152] The inner clamping cylinder 455 and two outer clamping cylinders of the consumable fixing unit squeeze the multiple heat-sealing pipes 82 of the consumable package body;

[0153] The moving end of the inner clamping cylinder 455 is kept in an extended state (so that the heat-sealing pipeline 82 can be in a straight state to facilitate subsequent heat-sealing separation), and after the moving ends of the two outer clamping cylinders are retracted, the multiple heat-sealing pipelines 82 of the consumable package body are cut by the sliding cutting plate 72 of the heat-sealing cutting assembly 7;

[0154] The moving end of the inner clamping cylinder 455 is retracted, and the moving ends of the two outer clamping cylinders are extended, thereby completing the heat sealing cutting.

[0155] By using the above steps and in conjunction with the above system, the purpose of batch filling can be achieved, thereby effectively improving the filling rate of the cell fluid.

Claims

1. A cell packaging system, characterized in that: include: Machine, cell bag shaking assembly, liquid dispensing supply assembly, consumables conveying assembly, filling assembly, heat sealing and cutting assembly, and finished product conveying assembly; The cell bag shaking component is arranged on the machine platform, and the cell bag shaking component is built with a cell mixing bag for filling supply; The consumables conveying assembly is arranged on one side of the cell bag shaking assembly, and is equipped with a plurality of consumables package bodies for receiving filling, the consumables package bodies are arranged in sequence, and the consumables conveying assembly is used to convey the consumables package bodies to the filling positions in sequence, each of the consumables package bodies comprises a consumables package dispensing head, a plurality of heat-sealed pipelines and a plurality of disposable sterile bags, the consumables package dispensing head has a plurality of dispensing branches, and the plurality of dispensing branches are connected one by one with the plurality of disposable sterile bags through corresponding heat-sealed pipelines; The liquid dispensing supply assembly is arranged on the machine platform, and one end of the assembly is connected to the liquid outlet pipeline of the cell mixing bag, and the other end is provided with a plurality of liquid dispensing pipelines, and the plurality of liquid dispensing pipelines are connected to the plurality of consumable package dispensing heads of the consumable package bodies in a one-to-one correspondence; The filling assembly is located in front of the consumables conveying assembly and is used for filling the consumables package body; The heat sealing and cutting assembly is arranged on the side wall of the machine platform and is used for heat sealing and cutting of the consumable package body to achieve sealing and separation of a plurality of disposable sterile bags; The finished product conveying assembly is arranged below the filling assembly and is used for carrying and conveying a plurality of the disposable sterile bags.

2. The cell packaging system according to claim 1, characterized in that: The liquid separation supply component includes a fixed frame, a sterile storage bag, a plurality of liquid separation pipelines and a plurality of liquid separation pinch valves. The sterile storage bag is fixed on the fixed frame. The input end of the sterile storage bag is connected to the liquid outlet pipeline of the cell mixing bag. One end of each of the plurality of liquid separation pipelines is connected to the output end of the sterile storage bag. The other ends of each of the plurality of liquid separation pipelines are also provided with a sterile connector. The sterile connector on the liquid separation pipeline is used to connect to the sterile connector of the consumable package body. The plurality of liquid separation pinch valves are arranged in a one-to-one correspondence with the plurality of liquid separation pipelines. Each liquid separation pinch valve is used to control the on-off of the corresponding liquid separation pipeline.

3. The cell packaging system according to claim 1, characterized in that: The consumable material conveying assembly comprises: a first conveyor belt unit and a plurality of consumable material loading boxes; The first conveyor belt unit is disposed on the machine platform and is used to convey materials in a front-to-back direction; A plurality of the consumable loading boxes are sequentially arranged on the first conveyor belt unit, and the consumable loading boxes are arranged in one-to-one correspondence with the consumable package body, and each consumable loading box has a plurality of accommodating spaces for placing disposable sterile bags.

4. The cell packaging system according to claim 3, characterized in that: The consumable material conveying assembly also includes: a consumable material pushing cylinder, a consumable material lifting cylinder, a baffle and a consumable material supporting frame; The baffle is arranged at the front end of the first conveyor belt unit and is used for limiting the position of the consumable material loading box; The consumable lifting cylinder and the consumable pushing cylinder are both arranged on the machine platform, the consumable lifting cylinder is used to lift the consumable loading box and make it exceed the height of the baffle, the edge of the machine platform has a notch, the outer dimensions of the notch are set according to the outer dimensions of the consumable loading box, and the consumable pushing cylinder is used to push the consumable loading box and move it to just above the notch; The consumable support frame includes two symmetrically arranged support structures, the bottom of the support structure is fixed on the machine platform, the tops of the two support structures have a preset gap, and the consumable package dispensing heads of the multiple consumable package bodies are all arranged in the preset gap and can move back and forth along the preset gap.

5. The cell packaging system according to claim 3, characterized in that: The finished product conveying assembly includes a second conveyor belt unit, which is fixed to the side wall of the machine platform and is used to convey materials in the left and right directions; The second conveyor belt unit includes a frame and two conveyor belt assemblies. The two conveyor belt assemblies are respectively arranged on both sides of the inner wall of the frame, and a gap is reserved between them.

6. The cell packaging system according to claim 5, characterized in that: The consumable material conveying assembly also includes a consumable material receiving unit and a consumable material fixing unit; The consumables receiving unit includes a lifting drive mechanism and a lifting support plate, wherein the lifting drive mechanism is installed on the side wall of the machine platform, the lifting support plate is connected to the moving end of the lifting drive mechanism, the lifting support plate can pass through the gap between the two conveyor belt assemblies, and the lifting support plate is equipped with a vacuum suction cup, which is used to absorb the consumables loading box; The consumable fixing unit includes a bracket, an inner clamping cylinder, two outer clamping cylinders and two consumable fixing cylinders. The inner clamping cylinder, the two outer clamping cylinders and the two consumable fixing cylinders are all installed on the bracket, and the inner clamping cylinder is located between the two outer clamping cylinders, the outer clamping cylinder is located between the two consumable fixing cylinders, and the bracket is fixed on the side wall of the machine.

7. The cell packaging system according to claim 1, characterized in that: The heat sealing and cutting assembly comprises: a positioning heating plate and a sliding cutting plate; The positioning heating plate is fixedly mounted on the side wall of the machine platform through a bracket; The sliding cutting plate is slidably mounted inside the machine platform and can move toward the positioning heating plate to clamp and cut the heat-sealed pipeline of the consumable package body.

8. The cell packaging system according to claim 7, characterized in that: A spring seat is provided on one side of the sliding cutting plate close to the positioning heating plate; When the sliding cutting plate moves in a direction close to the positioning heating plate and contacts the heat sealing pipeline of the consumable package body and the positioning heating plate, the spring seat can shrink to expose the cutting knife on the sliding cutting plate for cutting the consumable package body.

9. The cell packaging system according to claim 1, characterized in that: The filling assembly comprises: a multi-channel peristaltic pump and an exhaust pinch valve; The multiple heat-sealed pipelines of the consumables package body are all clamped in the multi-channel peristaltic pump, and the multi-channel peristaltic pump is used to simultaneously pump the liquid in the liquid separation pipeline to each disposable sterile bag of the consumables package body; The exhaust pinch valve is arranged on the exhaust pipe of the consumable package body and is used to control the on-off of the exhaust pipe.

10. The cell packaging system according to claim 9, characterized in that: The filling assembly also includes: a liquid level sensor and a sensor displacement cylinder; The sensor displacement cylinder is fixedly mounted on the side wall of the machine platform through a bracket, the liquid level sensor is connected to the moving end of the sensor displacement cylinder, and the liquid level sensor is used to sense the liquid level in the disposable sterile bag.

11. The cell packaging system according to claim 1, characterized in that: The liquid separation supply component, the consumable material conveying component, the filling component and the heat sealing and cutting component are each provided with two groups, and are respectively located on both sides of the cell bag shaking component.

12. The cell packaging system according to claim 1, characterized in that: The cell bag shaking component is a wave-type bioreactor or an extrusion-type mixing device.

13. The cell packaging system according to claim 1, characterized in that: The machine platform is also provided with a support frame, a liquid inlet peristaltic pump and a liquid outlet peristaltic pump; A plurality of sterile containers are hung on the support frame, and the plurality of sterile containers are used to store cell fluid, freezing fluid and culture medium respectively; The liquid outlet end of the sterile container is connected to the liquid inlet pipeline of the cell mixing bag through a sterile joint, and the liquid inlet peristaltic pump is arranged on the liquid inlet pipeline to pump any one of the cell fluid, freezing solution and culture medium or any combination thereof into the cell mixing bag; The liquid outlet peristaltic pump is arranged on the liquid outlet pipeline of the cell mixing bag, and is used to pump the liquid in the cell mixing bag into the sterile storage bag of the liquid separation supply assembly.

14. The cell packaging system according to claim 13, characterized in that: It also includes a control unit, and the liquid inlet peristaltic pump, the liquid outlet peristaltic pump, the cell bag shaking assembly, the liquid separation supply assembly, the consumable material conveying assembly, the filling assembly, the heat sealing and cutting assembly, and the finished product conveying assembly are all electrically connected to the control unit.

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