Disposable batch cell preparation transport case

Abstract

In order to solve the problem that cell viability is affected by too high or too low temperature in the cell preparation transportation process, the utility model provides a disposable batch cell preparation transportation box which comprises an outer box, the outer box is a shell with an opening in the upper end, a containing groove is formed in the outer box, and inner box clamping grooves are formed in the upper portions of the inner walls of the two opposite sides of the containing groove; the inner box is clamped in the outer box through an inner box clamping groove, an ice block containing cavity is formed between the lower portion of the inner box and the bottom of the containing groove in a spaced mode, multiple sets of cell preparation containing grooves which are evenly distributed at intervals are formed in the inner box, and multiple sets of heat dissipation holes communicated with the ice block containing cavity are formed in the cell preparation containing grooves; the box cover is clamped to the upper end of the outer box, the lower end face of the box cover is flush with the upper end face of the inner box, heat exchange is conducted through heat dissipation holes in the inner box and communicating cavities in the front side and the rear side of the inner box and the ice block containing cavity, the heat transfer speed is effectively controlled, and the condition that the temperature of the cell preparation is too low is prevented.

Description

Technical Field

[0001] The utility model relates to the technical field of cell preparation transportation devices, in particular to a disposable batch cell preparation transportation box. Background Art

[0002] Cell therapy is the use of the patient's own (or allogeneic) adult cells (or stem cells) to repair tissues and organs. It has been widely used in bone marrow transplantation, advanced liver cirrhosis, femoral head necrosis, malignant tumors, myocardial infarction and other diseases. The cell products prepared in the cell purification workshop must be suspended in physiological saline, sealed in a special cell preparation bag, and then transported to a medical institution at low temperature for cell infusion; low temperature can inhibit the activity of biological macromolecules and reduce the metabolic rate of living cells, thereby maintaining cell activity, but the specific temperature control range needs to be determined according to the specific environment of the cells. It is generally believed that the optimal transportation temperature for cell preparations is 15-25°C.

[0003] Incubators are often used for the transportation of cell preparations, including disposable foam incubators and reusable plastic incubators. The cell preparation bag is placed in the incubator, and an appropriate amount of ice packs are placed in the incubator to maintain a low temperature inside the incubator, which can effectively prevent the activity of the cell preparation from decreasing too quickly during transportation. Among them, disposable foam incubators are cheap and can be directly discarded after one use. They are easy to operate, but the disadvantage is that they have a simple structure and no other special functions. Reusable plastic incubators have beautiful appearances, come with temperature probes and displays, and have simple partitions or brackets inside, which can divide the space for ice cubes and cell preparations to a certain extent. The disadvantage is that they need to be cleaned and disinfected after use. They are relatively bulky, not suitable for logistics transportation, and the insulation effect is not as good as foam incubators.

[0004] The change in the temperature of the cell preparation comes from the absorption of heat by the ice on the one hand and the entry of external heat into the incubator through the gaps in the incubator on the other. Ordinary incubators do not have special temperature control functions. When the temperature of the ice is low in the early stage, the temperature of the cell preparation will drop rapidly to a lower temperature. Later, as the temperature of the ice rises, the heat absorption capacity cannot offset the entry of external heat in time, and the temperature of the cell preparation begins to rise rapidly again, which is not good for cell activity. In addition, ordinary incubators have a simple structure. If multiple cell preparations are transported at the same time, they can only be simply stacked, which can easily cause cell confusion. Utility Model Content

[0005] In order to solve the problem that the temperature is too high or too low during the transportation of cell preparations, which affects the cell activity, the utility model provides a disposable batch cell preparation transportation box, and the technical solution adopted is as follows:

[0006] A disposable bulk cell preparation transport box, characterized in that it comprises:

[0007] The outer box is a shell with an opening at the upper end, and a placement slot is provided inside, and inner box card slots are provided on the upper parts of the inner walls on opposite sides of the placement slot;

[0008] The inner box is connected to the inner box through the inner box slot, and an ice cube receiving cavity is formed between the lower part of the inner box and the bottom of the placement groove, and a plurality of groups of cell preparation placement grooves evenly distributed at intervals are arranged inside the inner box, and a plurality of heat dissipation holes communicating with the ice cube receiving cavity are arranged on the cell preparation placement grooves;

[0009] The box cover is clamped on the upper end of the outer box and the lower end surface is flush with the upper end surface of the inner box.

[0010] Furthermore, a plurality of groups of temperature probes are arranged under the box cover, the plurality of groups of temperature probes are distributed in one-to-one correspondence with the positions of the cell preparation placement slots, and a temperature display is arranged on the upper end surface of the box cover, and the temperature display is connected to the temperature probe signals.

[0011] Furthermore, a spacing is provided between the inner box side surface where the heat dissipation hole is located and the inner wall of the outer box, and a connecting cavity is formed between the inner box side surface and the inner wall of the outer box, and the heat dissipation hole is connected with the ice cube holding cavity at the bottom of the outer box through the connecting cavity.

[0012] Furthermore, the outer box, the inner box and the box cover are all made of disposable thermal insulation foam.

[0013] The beneficial effects of the utility model are:

[0014] 1. The outer box is placed on the outside of the inner box, and the inner box and the outer box form an ice cube holding chamber at the bottom. The cell preparation is placed inside the cell preparation placement slot of the inner box to separate the cell preparation and ice storage spaces. In addition, the inner box is made of thermal insulation foam material. The cell preparation does not exchange heat with the ice cubes through the bottom of the inner box, but only exchanges heat with the ice cubes in the ice cube holding chamber through the heat dissipation holes on the inner box and the connecting cavities on the front and rear sides of the inner box, so that the temperature of the cell preparation is slowly reduced to prevent the activity of the cell preparation from being reduced due to excessively low temperature;

[0015] 2. The temperature of the cell preparation can be observed in real time through the temperature probe installed in the cell preparation tank and the temperature display installed on the upper end of the box cover;

[0016] 3. The overall structure is made of disposable thermal insulation foam, which has good sealing and thermal insulation effects and effectively extends the insulation time. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 This is a schematic diagram of the structure of the utility model

[0018] Figure 2 This is a schematic diagram of the explosion structure of the utility model

[0019] Figure 3This is a cross-sectional view of the explosion structure of the utility model

[0020] Figure 4 Top view of the outer box

[0021] Figure 5 A top view of the outer box and inner box connected

[0022] Figure 6 This is a cross-sectional view of the utility model in the installed state

[0023] Among them, 1-box cover, 101-temperature probe, 102-temperature display, 2-inner box, 201-cell preparation placement slot, 202-heat dissipation hole, 3-outer box, 301-inner box card slot, 302-placement slot, 303-ice cube holding chamber, 304-connecting chamber. DETAILED DESCRIPTION

[0024] The exemplary embodiments of the present disclosure will be described in more detail below with reference to the accompanying drawings. Although the exemplary embodiments of the present disclosure are shown in the accompanying drawings, it should be understood that the present disclosure can be implemented in various forms and should not be limited by the embodiments set forth herein. On the contrary, these embodiments are provided to enable a more thorough understanding of the present disclosure and to fully convey the scope of the present disclosure to those skilled in the art.

[0025] In the description of the utility model, it is necessary to understand that the terms "upper", "lower", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", etc., indicating the orientation or position relationship, are based on the viewing direction or position relationship, and are only for the convenience of describing the utility model, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the utility model.

[0026] like Figure 1-Figure 6 The disposable bulk cell preparation transport box shown includes a box cover 1, an inner box 2 and an outer box 3, all of which are made of disposable thermal insulation foam material. The inner box 2 is arranged inside the outer box 3, and the box cover 1 is snapped onto the upper end of the outer box 3 and is located above the inner box 2.

[0027] Specifically, the outer box 3 is a rectangular shell structure without a cover on the upper end, and an upwardly penetrating placement groove 302 is arranged in the outer box 3 , and the upper parts of the inner walls on the left and right sides of the placement groove 302 are both provided with inner box card slots 301 .

[0028] The inner box 2 is a rectangular block structure as a whole. The left and right sides of the inner box 2 are respectively connected with the two inner box slots 301, and the area between the bottom of the inner box 2 and the bottom of the placement slot 302 is an ice cube receiving chamber 303 for placing ice cubes or ice bags. The upper end of the inner box 2 is provided with a plurality of groups of cell preparation placement slots 201 evenly distributed at intervals. The length of the cell preparation placement slots 201 is distributed in the vertical direction, such as Figure 4 and Figure 5 As shown, the width of the inner box 2 in the front-to-back direction is smaller than the width of the placement groove 302, that is, a certain distance is separated between the front and rear side surfaces of the inner box 2 and the front and rear inner walls of the outer box 3, thereby forming a connecting cavity 304, and a plurality of groups of heat dissipation holes 202 connected to the interior of the cell preparation placement groove 201 are arranged on the front and rear side walls of the inner box 2, and the heat dissipation holes 202 are connected to the ice cube holding cavity 303 through the connecting cavity 304, thereby generating heat exchange between the interior of the cell preparation placement groove 201 and the ice cube holding cavity 303.

[0029] The outer box 3 is put on the outside of the inner box 2, and the inner box 2 and the bottom of the outer box 3 form an ice cube holding chamber 303. The cell preparation does not exchange heat with the ice cubes through the bottom of the inner box 2, but only exchanges heat with the ice cube holding chamber through the heat dissipation holes 202 on the inner box 2 and the connecting chambers on the front and rear sides of the inner box 2, so that the temperature of the cell preparation is slowly reduced to prevent the activity of the cell preparation from being reduced due to too low temperature.

[0030] A convex structure is provided at the lower end of the box cover 1, which is engaged with the inner box slot 301 to be clamped on the top of the outer box 3, and the sum of the convex height of the box cover 1 and the height of the inner box 2 is equal to the height of the inner box slot 301, so that in the clamped state, the lower end surface of the box cover 1 is flush and sealed with the upper end surface of the inner box 2; a plurality of groups of temperature probes 101 are also connected below the box cover 1, and the plurality of groups of temperature probes 101 are distributed one-to-one with the plurality of groups of cell preparation placement slots 201 and can extend into the interior of the cell preparation placement slots 201; a temperature display 102 is provided on the upper end surface of the box cover 1, and the temperature display 102 is signal-connected to the temperature probe 101 for detecting and displaying the temperature inside the cell preparation placement slots 201.

[0031] When the device is in use, firstly, ice cubes or ice packs are placed at the bottom of the outer box 3, and the cell preparation is placed in the cell preparation placement slot 201, and then the inner box 2 is clamped into the outer box 3 through the inner box clamping slot 301, and then the multiple groups of temperature probes 101 on the box cover 1 are aligned with the multiple groups of cell preparation placement slots 201, and the box cover 1 is pressed downward so that it is clamped on the top of the outer box 3 and the lower end surface of the box cover 1 is flush with the upper end surface of the inner box 2, and the storage of the cell preparation is completed. During the transportation of the cell preparation, the temperature of each cell preparation can be displayed in real time through the temperature display 102. By storing the cell preparation through the device, the heat transfer speed can be effectively controlled to prevent the temperature from being too low.

[0032] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements can be made without departing from the principle of the present invention, and these improvements should also be regarded as the protection scope of the present invention.

Claims

1. A disposable bulk cell preparation transport box, characterized in that: include: The outer box is a shell with an opening at the upper end, and a placement slot is provided inside, and inner box card slots are provided on the upper parts of the inner walls on opposite sides of the placement slot; The inner box is connected to the outer box through the inner box card slot, and an ice cube receiving cavity is formed between the bottom of the inner box and the bottom of the placement groove. A plurality of groups of cell preparation placement grooves evenly distributed at intervals are arranged inside the inner box, and a plurality of heat dissipation holes communicating with the ice cube receiving cavity are arranged on the cell preparation placement grooves; The box cover is clamped on the upper end of the outer box and the lower end surface is flush with the upper end surface of the inner box.

2. The disposable bulk cell preparation transport box according to claim 1, characterized in that: A plurality of groups of temperature probes are arranged under the box cover, and the plurality of groups of temperature probes are distributed correspondingly to the positions of the cell preparation placement slots, and a temperature display is arranged on the upper end surface of the box cover, and the temperature display is connected with the temperature probe signals.

3. The disposable bulk cell preparation transport box according to claim 1, characterized in that: A spacing is provided between the inner box side surface where the heat dissipation hole is located and the inner wall of the outer box, and a connecting cavity is formed between the inner box side surface and the inner wall of the outer box, and the heat dissipation hole is connected with the ice cube containing cavity at the bottom of the outer box through the connecting cavity.

4. The disposable bulk cell preparation transport box according to claim 1, characterized in that: The outer box, the inner box and the box cover are all made of disposable thermal insulation foam.

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