Needle fixing device for gene editing

Abstract

The utility model relates to the technical field of gene editing, in particular to a needle fixing device for gene editing, which comprises a support plate I. The top of the support plate I is fixedly connected with a support base, and a moving component is arranged in the support base; the moving assembly comprises a rotating motor, the rotating motor is fixedly mounted on the right side of the supporting base, a moving groove is formed in the top of the supporting base, a threaded rod is rotationally connected into the moving groove, and a limiting sliding groove is formed in the position, located on the top of the supporting base, of the outer end of the moving groove; and a moving block is movably installed in the moving groove, a threaded hole is formed in the moving block, the threaded hole is in threaded connection with the threaded rod, and a limiting sliding block is fixedly connected to the bottom of the moving block. According to the needle head fixing device for gene editing, automation and practicability are improved, workers are prevented from manually adjusting the position of a needle head, the experiment efficiency of the workers is improved, and use of the workers is facilitated.

Description

Technical Field

[0001] The utility model relates to the technical field of gene editing, in particular to a needle fixing device for gene editing. Background Art

[0002] Gene editing, also known as genome editing or genome engineering, is an emerging and relatively precise genetic engineering technology that can modify specific target genes in the genome of an organism.

[0003] Gene editing relies on genetically engineered nucleases, also known as "molecular scissors", to produce site-specific double-strand breaks at specific locations in the genome, inducing organisms to repair DSBs through non-homologous end joining or homologous recombination, which is an error-prone repair process and can lead to targeted mutations.

[0004] During the gene editing process, a gene editing needle fixing device is needed to fix the needle. However, some existing gene editing needle fixing devices require manual adjustment of the needle position during use, which reduces the experimental efficiency of the staff and is inconvenient for the staff to use. Utility Model Content

[0005] The purpose of the utility model is to provide a gene editing needle fixing device to solve the problem in the above background technology that the position of the needle needs to be adjusted manually, thereby reducing the experimental efficiency of the staff. To achieve the above purpose, the utility model provides the following technical solutions: a gene editing needle fixing device, including a support plate 1, the top of the support plate 1 is fixedly connected to a support base, and a moving component is arranged inside the support base;

[0006] The moving assembly includes a rotating motor, which is fixedly installed on the right side of the supporting base, a moving groove is provided on the top of the supporting base, a threaded rod is rotatably connected inside the moving groove, a limiting slide groove is provided on the outer end of the moving groove at the top of the supporting base, a moving block is movably installed inside the moving groove, a threaded hole is provided inside the moving block, the threaded hole is threadedly connected to the threaded rod, a limiting slider is fixedly connected to the bottom of the moving block, and the limiting slider is adapted to the limiting slide groove;

[0007] The limiting slide groove is distributed parallel to the top of the supporting base front and back, and the transmission end of the rotating motor passes through the interior of the supporting base and is fixedly connected to one end of the threaded rod. The moving component is arranged so that when the needle is above the moving block, the staff starts the rotating motor to drive the threaded rod at its transmission end, so that the moving block is threadedly connected to the threaded rod through the threaded hole and moves inside the moving groove. At the same time, the limiting slide groove limits the moving block, so that the staff can automatically adjust the position of the needle, thereby improving automation and practicality, avoiding the staff from manually adjusting the position of the needle, improving the staff's experimental efficiency, and facilitating the staff's use.

[0008] Further preferably, an adjustment component is provided on the top of the moving block, and the adjustment component includes an auxiliary groove, which is opened on the top of the moving block, and the auxiliary groove is rotatably connected to a roller inside, and the outer side of the roller is fixedly connected to a support plate. The adjustment component is set up so that when the needle is at the top of the support plate, the staff can press the adjustment button to drive the adjustment rod to press the blocking nail to retract the blocking nail, thereby causing the lifting rod to descend inside the lifting groove. At the same time, another blocking nail of the lifting rod will be stuck in the inside of the slot to fix the needle, which is convenient for the staff to adjust the angle of the needle, effectively improves the practicality and convenience, and facilitates the use of the staff.

[0009] Further preferably, a lifting groove is provided at the bottom of the auxiliary groove, a lifting rod is fixedly connected to the bottom of the support plate, the lifting rod is adapted to the lifting groove, a card slot is provided on the inner wall of the lifting groove, and a blocking nail is movably installed on one side of the lifting rod.

[0010] Further preferably, the retaining nails are distributed in parallel up and down to one side of the lifting rod, the retaining nails are adapted to the slot, an adjustment button is movably installed on the back of the moving block, an adjustment rod is fixedly connected to one side of the adjustment button, and the adjustment rod is located inside the slot and adapted to the retaining nails.

[0011] Further preferably, a fixing component is provided on the top of the support plate, and the fixing component includes a clamping block 1, and the clamping block 1 is fixedly installed on the top of the support plate, and the clamping block 1 is symmetrically distributed on the left and right. A spring 1 is fixedly connected to one opposite side of the clamping block 1, and a support plate 2 is fixedly connected to the other side of the spring 1. Due to the setting of the fixing component, when the staff places the needle on the top of the support plate, the spring 1 will drive the support plate 2 to fix the needle through its own elastic force, which effectively improves the stability of the staff's experiment and facilitates the staff's use.

[0012] Further preferably, an installation component is provided on the outer side of the support plate one, and the installation component includes a bolt, the bolt is threadedly connected to the top of the support plate one, the bolt passes through the interior of the support plate one, the bottom of the bolt is rotatably connected to a clamping block two, the top of the clamping block two is fixedly connected to a spring two, the top of the spring two is fixedly connected to the bottom of the support plate one, the top of the clamping block two is located on one side of the spring two and is fixedly connected to an anti-slip pad. The installation of the installation component effectively improves the installation efficiency of the staff, increases the scope of application to the scene environment, improves the practicability, and facilitates the use of the staff.

[0013] Further preferably, a charging port is opened on the left side of the support base, and a control button is movably installed below the charging port on the left side of the support base, and the control button is distributed in parallel front and back to the left side of the support base.

[0014] Compared with the prior art, the utility model has the following beneficial effects:

[0015] In the utility model, the moving component is arranged, when the needle is above the moving block, the staff starts the rotating motor to drive the threaded rod at its transmission end, so that the moving block is threadedly connected with the threaded rod through the threaded hole and moves inside the moving groove, and the limiting slide groove limits the moving block, so that the staff can automatically adjust the position of the needle, thereby improving automation and practicality, avoiding the staff from manually adjusting the position of the needle, improving the staff's experimental efficiency, and facilitating the staff's use.

[0016] In the utility model, the adjustment component is arranged, when the needle is at the top of the support plate, the staff can press the adjustment button to drive the adjustment rod to press the blocking nail, so that the blocking nail retracts, thereby causing the lifting rod to descend inside the lifting slot, and at the same time, another blocking nail of the lifting rod will be stuck in the inside of the slot to fix the needle, which is convenient for the staff to adjust the angle of the needle, effectively improves the practicability and convenience, and is convenient for the staff to use.

[0017] In the utility model, with the setting of the fixing component, when the staff places the needle on the top of the support plate, the spring 1 will drive the support plate 2 to fix the needle through its own elastic force, which effectively improves the stability of the staff's experiment and facilitates the use of the staff. The installation of the installation component effectively improves the installation efficiency of the staff, increases the scope of application of the scene environment, improves the practicability, and facilitates the use of the staff. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 It is a schematic diagram of the overall three-dimensional structure of the utility model;

[0019] Figure 2 It is a schematic diagram of the overall three-dimensional structure of the utility model;

[0020] Figure 3 It is a schematic diagram of the overall three-dimensional structure of the utility model;

[0021] Figure 4 It is a schematic diagram of the overall three-dimensional structure of the utility model;

[0022] Figure 5 It is a partial plane structural schematic diagram of the utility model;

[0023] Figure 6 It is a schematic diagram of the second structure of a local plane of the utility model.

[0024] In the figure: 1. Support plate 1; 2. Support base; 3. Moving component; 4. Adjustment component; 5. Fixed component; 6. Installation component; 7. Charging port; 8. Control button; 301. Rotating motor; 302. Moving slot; 303. Threaded rod; 304. Limiting slide slot; 305. Moving block; 306. Threaded hole; 307. Limiting slider; 401. Auxiliary slot; 402. Roller; 403. Support plate; 404. Lifting slot; 405. Lifting rod; 406. Slot; 407. Stop nail; 408. Adjustment button; 409. Adjustment rod; 501. Clamping block 1; 502. Spring 1; 503. Support plate 2; 601. Bolt; 602. Clamping block 2; 603. Spring 2; 604. Anti-slip pad. DETAILED DESCRIPTION

[0025] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technical personnel in this field without creative work are within the scope of protection of the utility model.

[0026] See also Figure 1 - Figure 6 The utility model provides a technical solution: a gene editing needle fixing device, comprising a support plate 1, a support base 2 is fixedly connected to the top of the support plate 1, and a moving component 3 is arranged inside the support base 2;

[0027] The moving assembly 3 includes a rotating motor 301, which is fixedly installed on the right side of the supporting base 2. A moving groove 302 is provided on the top of the supporting base 2. A threaded rod 303 is rotatably connected to the inside of the moving groove 302. A limiting slide groove 304 is provided on the outer end of the moving groove 302 at the top of the supporting base 2. A moving block 305 is movably installed inside the moving groove 302. A threaded hole 306 is provided inside the moving block 305. The threaded hole 306 is threadedly connected to the threaded rod 303. A limiting slider 307 is fixedly connected to the bottom of the moving block 305. The limiting slider 307 is adapted to the limiting slide groove 304.

[0028] The limiting slide grooves 304 are distributed in parallel front and back to the top of the support base 2 , and the driving end of the rotating motor 301 passes through the interior of the support base 2 and is fixedly connected to one end of the threaded rod 303 .

[0029] In this embodiment, Figure 1 and Figure 5 As shown, an adjustment component 4 is provided on the top of the moving block 305, and the adjustment component 4 includes an auxiliary groove 401, which is opened on the top of the moving block 305, and the auxiliary groove 401 is rotatably connected with a roller 402 inside, and the outer side of the roller 402 is fixedly connected with a support plate 403, and a lifting groove 404 is opened at the bottom of the auxiliary groove 401, and a lifting rod 405 is fixedly connected to the bottom of the support plate 403, and the lifting rod 405 is adapted to the lifting groove 404, and a card slot 406 is opened on the inner wall of the lifting groove 404, and a stop nail 407 is movably installed on one side of the lifting rod 405, and the stop nail 407 is distributed in parallel to one side of the lifting rod 405 up and down, and the stop nail 407 is adapted to the card slot 406, and an adjustment button 408 is movably installed on the back side of the moving block 305, and an adjustment rod 409 is fixedly connected to one side of the adjustment button 408, and the adjustment rod 409 is located inside the card slot 406 and adapted to the stop nail 407.

[0030] In this embodiment, Figure 5 and Figure 6 As shown, a fixing assembly 5 is provided on the top of the support plate 403, and the fixing assembly 5 includes a clamping block 501, which is fixedly installed on the top of the support plate 403, and the clamping block 501 is symmetrically distributed on the left and right. A spring 502 is fixedly connected to the opposite side of the clamping block 501, and the other side of the spring 502 is fixedly connected to the support plate 2 503.

[0031] In this embodiment, Figure 1 , Figure 2 and Figure 3As shown, a mounting assembly 6 is provided on the outer side of the support plate 1, and the mounting assembly 6 includes a bolt 601, which is threadedly connected to the top of the support plate 1, and the bolt 601 passes through the interior of the support plate 1, and the bottom of the bolt 601 is rotatably connected to a clamping block 2 602, and the top of the clamping block 2 602 is fixedly connected to a spring 2 603, and the top of the spring 2 603 is fixedly connected to the bottom of the support plate 1, and the top of the clamping block 2 602 is located on one side of the spring 2 603 and is fixedly connected to an anti-slip pad 604.

[0032] In this embodiment, Figure 1 As shown, a charging port 7 is provided on the left side of the support base 2, and a control button 8 is movably installed below the charging port 7 on the left side of the support base 2, and the control button 8 is distributed parallel to the front and back on the left side of the support base 2.

[0033] The use method and advantages of the utility model: When the gene editing needle fixing device is used, the working process is as follows:

[0034] like Figure 1 , Figure 2 , Figure 3 , Figure 4 , Figure 5 and Figure 6 As shown, during use, the staff first places the needle on the top of the support plate 403, and the spring 1 502 will drive the support plate 2 503 to fix the needle through its own elastic force, and then start the rotating motor 301, so that the rotating motor 301 drives the threaded rod 303 at its transmission end, so that the moving block 305 is threadedly connected with the threaded rod 303 through the threaded hole 306 to move inside the moving groove 302, and at the same time, the limiting slide groove 304 will limit the moving block 305, so that the staff can automatically adjust the position of the needle. Finally, the staff can press the adjustment button 408 to drive the adjustment rod 409 to press the blocking nail 407, so that the blocking nail 407 retracts, thereby causing the lifting rod 405 to descend inside the lifting groove 404, and at the same time, another blocking nail 407 of the lifting rod 405 will be stuck in the inside of the card slot 406 to fix the needle, which is convenient for the staff to adjust the angle of the needle.

[0035] The above shows and describes the basic principle, main features and advantages of the utility model. Technical staff in this industry should understand that the utility model is not limited by the above embodiments. The above embodiments and descriptions are only preferred examples of the utility model and are not used to limit the utility model. Without departing from the spirit and scope of the utility model, the utility model will have various changes and improvements, which fall within the scope of the utility model to be protected. The scope of protection of the utility model is defined by the attached claims and their equivalents.

Claims

1. A gene editing needle fixing device, comprising a support plate (1), characterized in that: The top of the support plate 1 (1) is fixedly connected to a support base (2), and a moving component (3) is arranged inside the support base (2); The moving assembly (3) comprises a rotating motor (301), the rotating motor (301) is fixedly mounted on the right side of the supporting base (2), a moving groove (302) is provided on the top of the supporting base (2), a threaded rod (303) is rotatably connected inside the moving groove (302), a limiting slide groove (304) is provided at the outer end of the moving groove (302) located at the top of the supporting base (2), a moving block (305) is movably mounted inside the moving groove (302), a threaded hole (306) is provided inside the moving block (305), the threaded hole (306) is threadedly connected to the threaded rod (303), a limiting slide block (307) is fixedly connected to the bottom of the moving block (305), and the limiting slide block (307) is adapted to the limiting slide groove (304); The limiting slide grooves (304) are distributed in parallel front and back to the top of the support base (2), and the transmission end of the rotating motor (301) passes through the interior of the support base (2) and is fixedly connected to one end of the threaded rod (303).

2. A gene editing needle fixing device according to claim 1, characterized in that: An adjustment component (4) is arranged on the top of the moving block (305), and the adjustment component (4) comprises an auxiliary groove (401). The auxiliary groove (401) is opened on the top of the moving block (305), a roller (402) is rotatably connected inside the auxiliary groove (401), and a support plate (403) is fixedly connected to the outside of the roller (402).

3. A gene editing needle fixing device according to claim 2, characterized in that: A lifting groove (404) is provided at the bottom of the auxiliary groove (401), a lifting rod (405) is fixedly connected to the bottom of the support plate (403), the lifting rod (405) is adapted to the lifting groove (404), a clamping groove (406) is provided on the inner wall of the lifting groove (404), and a blocking nail (407) is movably installed on one side of the lifting rod (405).

4. A gene editing needle fixing device according to claim 3, characterized in that: The retaining nail (407) is distributed in parallel up and down to one side of the lifting rod (405), and the retaining nail (407) is adapted to the card slot (406). An adjustment button (408) is movably installed on the back of the moving block (305), and an adjustment rod (409) is fixedly connected to one side of the adjustment button (408). The adjustment rod (409) is located inside the card slot (406) and adapted to the retaining nail (407).

5. A gene editing needle fixing device according to claim 3, characterized in that: A fixing assembly (5) is arranged on the top of the support plate (403), and the fixing assembly (5) comprises a clamping block 1 (501), and the clamping block 1 (501) is fixedly installed on the top of the support plate (403), and the clamping block 1 (501) is symmetrically distributed on the left and right sides, and a spring 1 (502) is fixedly connected to the opposite side of the clamping block 1 (501), and the other side of the spring 1 (502) is fixedly connected to the support plate 2 (503).

6. A gene editing needle fixing device according to claim 1, characterized in that: The outer side of the support plate 1 (1) is provided with a mounting assembly (6), and the mounting assembly (6) includes a bolt (601), the bolt (601) is threadedly connected to the top of the support plate 1 (1), the bolt (601) passes through the inside of the support plate 1 (1), the bottom of the bolt (601) is rotatably connected to a clamping block 2 (602), the top of the clamping block 2 (602) is fixedly connected to a spring 2 (603), the top of the spring 2 (603) is fixedly connected to the bottom of the support plate 1 (1), and the top of the clamping block 2 (602) is located on one side of the spring 2 (603) and is fixedly connected to an anti-slip pad (604).

7. A gene editing needle fixing device according to claim 1, characterized in that: A charging port (7) is provided on the left side of the support base (2); a control button (8) is movably installed below the charging port (7) and located on the left side of the support base (2); the control button (8) is distributed in parallel front and back to the left side of the support base (2).

Images