Automatic column assembling machine

Abstract

The utility model discloses an automatic column packing machine which comprises a machine case, and the interior of the machine case is divided into a column packing bin, a pipeline connecting bin and an electric appliance bin. A plurality of mounting openings are formed in the bin wall between the pipeline connecting bin and the electric appliance bin, each mounting opening is used for detachably mounting and fixing one mounting frame, each mounting frame is used for mounting a liquid path switching valve or a pump body, and after the mounting frames are mounted at the mounting openings, the liquid path switching valves or the pump bodies are mounted on the mounting openings. The liquid path switching valve or the pump body on the liquid path switching valve or the pump body is used for being connected with a pipeline and located in the pipeline connecting bin, and the liquid path switching valve or the pump body is used for being electrically connected with a wire and located in the electric appliance bin. According to the utility model, all the devices required to be used in the column assembling process are reasonably integrated on one device, and all the devices can be modularly combined according to the actual requirements of users.

Description

Technical Field

[0001] The utility model relates to the technical field of liquid chromatography, in particular to an automatic column loading machine. Background Art

[0002] Column packing refers to the process of filling chromatographic fillers into the chromatographic column tube. Currently, most of the column packing equipment is purchased by users themselves, and then built and assembled by themselves. There is no column packing equipment on the market that can reasonably integrate various components into one machine and can modularly combine various components according to the user's needs. Utility Model Content

[0003] The utility model aims to provide an automatic column packing machine, and solves the technical problem of rationally integrating various devices required in the column packing process into one device, and being able to modularly combine the various devices according to the actual needs of users.

[0004] To achieve the above-mentioned purpose, the solution of the utility model is: an automatic column loading machine, comprising a chassis, wherein the chassis is divided into a column loading compartment, a pipeline connection compartment and an electrical compartment;

[0005] The column loading bin is provided for detachable installation of multiple homogenization tanks and multiple chromatographic columns, and multiple installation ports are opened on the bin wall between the pipeline connection bin and the electrical bin, each installation port is used for detachable installation and fixation of a mounting bracket, and each mounting bracket is used for installation of a liquid circuit switching valve or a pump body, and after the mounting bracket is installed in the installation port, the position of the liquid circuit switching valve or pump body thereon for connecting the pipeline is located in the pipeline connection bin, and the position for the electrical connection wire is located in the electrical bin.

[0006] Furthermore, the bottoms of the column loading bin and the pipeline connection bin are respectively provided with liquid receiving grooves, which can receive liquid dripping from above.

[0007] Furthermore, a liquid level sensor is installed in the liquid receiving tank.

[0008] Furthermore, a plurality of C-shaped elastic claws are arranged on the inner side wall of the column packing bin, and the C-shaped elastic claws are used for inserting the chromatographic column to clamp the chromatographic column, thereby making the chromatographic column detachable and installed in the column packing bin.

[0009] Furthermore, a plurality of clamps are provided on the inner side wall of the column loading bin, and the clamps are used to tighten or loosen the homogenization tank, so that the homogenization tank can be detachably installed in the column loading bin.

[0010] Furthermore, a first pipeline through-hole is provided between the column loading bin and the pipeline connection bin, and a second pipeline through-hole connected to the outside of the chassis is provided in the pipeline connection bin.

[0011] Furthermore, a power supply and a control panel are installed in the electrical compartment, and the power supply, the control panel, the pump body and the liquid circuit switching valve are electrically connected.

[0012] Furthermore, a pipeline connection compartment opening is formed on the outer wall of the chassis at a position corresponding to the pipeline connection compartment, a panel is pivotally connected to one side edge of the pipeline connection compartment opening, a touch screen is arranged on the panel, and the touch screen is electrically connected to the control board.

[0013] Furthermore, a pump body, a first liquid circuit switching valve and a second liquid circuit switching valve are installed on the wall between the pipeline connection compartment and the electrical compartment through the cooperation of the installation port and the installation frame;

[0014] The pump body has a pump body liquid inlet and a pump body liquid outlet, and the pump body is used to pump the liquid in the pump body liquid inlet to the pump body liquid outlet;

[0015] The first liquid path switching valve has a first valve port and a plurality of second valve ports, and is used to switch the first valve port to one of the second valve ports;

[0016] The second fluid path switching valve has a third valve port and a plurality of fourth valve ports, and is used to switch the third valve port to one of the fourth valve ports;

[0017] A homogenizing tank inner cavity is formed in the homogenizing tank, a displacement liquid inlet is passed through the top end, and a homogenizing tank liquid outlet is passed through the bottom end;

[0018] A chromatographic column inner cavity is formed in the chromatographic column, a chromatographic column liquid inlet is penetrated at the top end, and a chromatographic column liquid outlet is penetrated at the bottom end;

[0019] Each second valve port is used to communicate with a liquid storage tank, and the first valve port is used to communicate with the liquid inlet of the pump body;

[0020] The third valve port is used to connect the liquid outlet of the pump body, and each fourth valve port is used to connect a displacement liquid inlet, or a chromatographic column inlet, or a liquid storage tank. When the fourth valve port is used to connect the displacement liquid inlet, the corresponding homogenization tank outlet is used to connect a chromatographic column inlet.

[0021] Furthermore, a third liquid circuit switching valve and a fourth liquid circuit switching valve are installed on the compartment wall between the pipeline connection compartment and the electrical compartment through the cooperation of the installation port and the installation frame;

[0022] There is also an air overflow port at the top of the homogenization tank;

[0023] The third fluid path switching valve has a fifth valve port and a plurality of sixth valve ports, and is used to switch the fifth valve port to one of the sixth valve ports;

[0024] The fourth fluid path switching valve has a seventh valve port and a plurality of eighth valve ports, and is used to switch the seventh valve port to one of the eighth valve ports;

[0025] Each sixth valve port is used to connect to an air overflow port, or a chromatographic column outlet, or a fourth valve port, the fifth valve port is used to connect to the seventh valve port, at least one of the eighth valve ports is blocked, and each of the remaining eighth valve ports is used to connect to a liquid storage tank.

[0026] After adopting the above scheme, the beneficial effects of the utility model are: a column packing bin, a pipeline connection bin and an electrical compartment are separated in a chassis; the column packing bin is detachably installed for multiple homogenization tanks and multiple chromatographic columns, so that the user can install a corresponding number of homogenization tanks and chromatographic columns as needed, and multiple installation ports are opened on the bin wall between the pipeline connection bin and the electrical compartment, each installation port is used for a mounting bracket to be detachably installed and fixed, and each mounting bracket is used for the installation of a liquid circuit switching valve or a pump body, and after the mounting bracket is installed in the installation port, the position of the liquid circuit switching valve or pump body thereon for connecting the pipeline is located in the pipeline connection bin, and the position for the electrical connection wire is located in the electrical compartment, so that the user can install the corresponding switching valve and pump body as needed, and the switching valve and the pump body can complete the wiring in the electrical compartment, and complete the pipeline connection in the pipeline connection bin, and then only need to connect the corresponding pipeline to the corresponding chromatographic column and homogenization tank to put it into use, and the pipeline connection bin and the electrical compartment are separated, realizing the separation of water and electricity, and the use process is safer. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] Figure 1 It is a three-dimensional diagram of the utility model;

[0028] Figure 2 It is a partial exploded view of the utility model;

[0029] Figure 3 for Figure 2 A partial enlarged view of the middle A;

[0030] Figure 4 This is a diagram of the structure after removing the side wall of the chassis at the electrical compartment and opening the panel;

[0031] Figure 5 This is a schematic diagram of the disassembled liquid circuit switching valve and pump body;

[0032] Figure 6 This is a schematic diagram of installing two liquid switching valves to load the column;

[0033] Figure 7 A schematic diagram for installing and activating two fluid circuit switching valves;

[0034] Figure 8 A schematic diagram for installing and activating four fluid path switching valves;

[0035] Fig. 9 This is a schematic diagram of the installation of four liquid circuit switching valves for cleaning;

[0036] Fig.10 Schematic diagram of installing four liquid switching valves to exhaust gas before column loading;

[0037] Fig.11 Schematic diagram of installing four liquid path switching valves and loading the column.

[0038] Explanation of the reference numbers: 1-chassis, 2-column compartment, 3-pipeline connection compartment, 4-electrical compartment, 5-homogenization tank, 6-chromatographic column, 7-compartment wall, 8-installation port, 9-installation frame, 10-liquid circuit switching valve, 11-pump body, 12-liquid receiving tank, 13-liquid level sensor, 14-C-shaped elastic claw, 15-clamp, 16-first pipeline penetration port, 17-second pipeline penetration port, 18-power supply, 19-control board, 20-pipeline connection compartment opening, 21-panel, 23-touch screen, 24-pump body liquid inlet, 25-pump body liquid outlet, 26-first valve port, 27-the second valve port, 28-the third valve port, 29-the fourth valve port, 30-the inner cavity of the homogenization tank, 31-the inlet of the displacement liquid, 32-the liquid outlet of the homogenization tank, 33-the inner cavity of the chromatographic column, 34-the liquid inlet of the chromatographic column, 35-the liquid outlet of the chromatographic column, 36-the liquid storage tank, 37-the air overflow port, 38-the fifth valve port, 39-the sixth valve port, 40-the seventh valve port, 41-the eighth valve port, 42-the drain port, 43-the door of the column loading chamber, 44-the first liquid circuit switching valve, 45-the second liquid circuit switching valve, 46-the third liquid circuit switching valve, 47-the fourth liquid circuit switching valve. DETAILED DESCRIPTION

[0039] The present invention is described in detail below with reference to the accompanying drawings and specific embodiments.

[0040] In the claims, specification and the above-mentioned drawings of the present invention, unless otherwise explicitly defined, directional words, such as the use of terms such as "center", "lateral", "longitudinal", "horizontal", "vertical", "top", "bottom", "inside", "outside", "up", "down", "front", "back", "left", "right", "clockwise", "counterclockwise" and the like to indicate directions or positional relationships are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the referred device or element must have a specific orientation or be constructed and operated in a specific orientation, so they cannot be understood as limiting the specific protection scope of the present invention.

[0041] The utility model provides an automatic column loading machine, such as Figure 1-11As shown, it includes a chassis 1, and the chassis 1 is separated into a column storage bin 2, a pipeline connection bin 3 and an electrical appliance bin 4; the column storage bin 2 is provided with a plurality of homogenizing tanks 5 and a plurality of chromatographic columns 6 for detachable installation, and the homogenizing tanks 5 and the chromatographic columns 6 can adopt existing structures without specific limitation, and a plurality of mounting ports 8 are provided on a bin wall 7 between the pipeline connection bin 3 and the electrical appliance bin 4, and each mounting port 8 is used for a mounting bracket 9 to be detachably installed and fixed, and each mounting bracket 9 is used for installing a liquid circuit switching valve 10 or a pump body 11, and after the mounting bracket 9 is installed in the mounting port 8, the position of the liquid circuit switching valve 10 or the pump body 11 thereon for connecting the pipeline is located at the pipeline connection In the chamber 3, the position for the electrical connection wire is located in the electrical chamber 4, and then the user can install the corresponding number of chromatographic columns 6 and homogenizing tanks 5 in the column chamber 2 according to their own needs, and install the corresponding switching valve 10 and pump body 11 through the installation port 8 and the mounting frame 9. The switching valve 10 and the pump body 11 can complete the circuit electrolysis in the electrical chamber 4, and the pipeline connection can be completed in the pipeline connection chamber 3, and then the corresponding pipeline is connected to the homogenizing tank 5 or the chromatographic column 6, and it can be put into use. In the whole use process, the pipeline connection chamber 3 and the electrical chamber 4 are separated, realizing the separation of water and electricity, and it is safer to use. More specifically in this embodiment, the chassis 1 is in the shape of a square box, the pipeline connection chamber 4 is located in the front, and the column chamber 2 and the electrical chamber 4 are located at the rear of the pipeline connection chamber 4, and the two are arranged on the left and right.

[0042] In order to receive the liquid dripping into the column loading bin 2 and the pipeline connection bin 3 during use, so as to prevent the liquid from flowing out and contaminating the laboratory, or flowing into the electrical equipment and causing safety accidents, it is preferred that the bottoms of the column loading bin 2 and the pipeline connection bin 3 are respectively provided with liquid receiving grooves 12, and the liquid receiving grooves 12 can receive the liquid dripping from the top; more preferably, a liquid discharge port 42 is provided on the side wall of the liquid receiving groove 12, and when in use, a water pipe can be connected to the liquid discharge port 42 to drain and store the liquid collected in the liquid receiving groove 12; more preferably, a liquid level sensor 13 is also installed in the liquid receiving groove 12, and the liquid level sensor 13 is electrically connected to the control board 19 in the electrical compartment 4, so that when the liquid level in the liquid receiving groove 12 is higher than a preset value, the liquid level sensor 13 sends a corresponding signal to the control board 19.

[0043] The following provides a specific structure for detachably installing the chromatographic column 6 and the homogenization tank 5 in the column packing bin 2, wherein a plurality of C-shaped elastic claws 14 are provided on the inner side wall of the column packing bin 2, and the C-shaped elastic claws 14 are used for inserting the chromatographic column 6 to clamp the chromatographic column 6, thereby making the chromatographic column 6 detachably installed in the column packing bin 2. More specifically, in the present embodiment, a total of 12 C-shaped elastic claws 14 are provided, two in a group, and each group is arranged horizontally, and the two C-shaped elastic claws 14 in a group are spaced up and down to clamp the upper and lower halves of the chromatographic column 6, respectively, so as to make the clamping more stable. A plurality of clamps 15 are provided on the inner side wall of the column loading bin 2, and the clamps 15 are used to tighten or loosen the homogenization tank 5, so that the homogenization tank 5 can be detachably installed in the column loading bin 2. More specifically, in the present embodiment, each clamp 15 includes two C-shaped rings arranged opposite to each other, one of the two C-shaped rings is fixedly arranged, and the other C-shaped ring is hingedly installed on one side edge, and the other side edges of the two C-shaped rings are detachably connected by bolts. The number and arrangement of the clamps 15 are the same as those of the C-shaped elastic claws 14.

[0044] In order to facilitate the installation of pipelines, a first pipeline through-hole 16 is preferably provided between the column loading bin 2 and the pipeline connection bin 3, and more preferably two first pipeline through-holes 16 are provided, one for the pipeline from the pipeline connection bin 3 to the column loading bin 2 to pass through, and the other for the pipeline from the column loading bin 2 to the pipeline connection bin 3 to pass through, so as to facilitate troubleshooting and maintenance during subsequent use. The pipeline connection bin 3 is provided with a second pipeline through-hole 17 connected to the outside of the chassis 1, so that the external pipeline can be introduced into the pipeline connection bin 3 through the second pipeline through-hole 17 and connected to the corresponding liquid switching valve 10 or pump body 11.

[0045] In a more specific embodiment, a power supply 18 and a control panel 19 are installed in the electrical compartment 4. The power supply 18, the control panel 19, the pump body 11 and the liquid circuit switching valve 10 are electrically connected, so that power is supplied by the power supply 18, and the pump body 11 and the liquid circuit switching valve 10 are controlled by the control panel 19. The pump body 11 is controlled to start or stop pumping liquid, and the switching valve 10 is controlled to switch to the corresponding gear position. This is a conventional setting in this field and a conventional technical means, which will not be described in detail.

[0046] Preferably, a pipeline connection compartment opening 20 is formed on the outer wall of the chassis 1 at a position corresponding to the pipeline connection compartment 3, and a panel 21 is pivotally connected to one side edge of the pipeline connection compartment opening 20. A touch screen 23 is provided on the panel 21, and the touch screen 23 is electrically connected to the control board 19, so that the panel 21 can be opened at any time to adjust or repair the pipeline connection in the pipeline connection compartment 3. The touch screen 23 can be used to display and switch the working status of the pump body 11 and the liquid circuit switching valve 10, and the monitoring signal of the liquid level sensor 13 can also be displayed through the touch screen 23.

[0047] To facilitate the connection of the internal pipeline of the column loading bin 2 and observe the column loading process, the outer wall of the chassis 1 at the column loading bin 2 is preferably opened and removably covered with a column loading bin door 43, which is made of a brown translucent acrylic plate.

[0048] In a more specific embodiment, a pump body 11, a first liquid circuit switching valve 44 and a second liquid circuit switching valve 45 can be installed on the warehouse wall 7 between the pipeline connection warehouse 3 and the electrical warehouse 4 through the cooperation of the installation port 8 and the mounting frame 9; the pump body 11 has a pump body liquid inlet 24 and a pump body liquid outlet 25, and the pump body 11 is used to pump the liquid in the pump body liquid inlet 24 to the pump body liquid outlet 25; the first liquid circuit switching valve 44 has a first valve port 26 and a plurality of second valve ports 27, and is used to switch the first valve port 26 to one of the second valve ports 27; the second liquid circuit switching valve 45 has a third valve port 28 and a plurality of fourth valve ports 29, and is used to switch the third The valve port 28 is connected to one of the fourth valve ports 29; a homogenizing tank cavity 30 is formed in the homogenizing tank 5, with a displacement liquid inlet 31 at the top and a homogenizing tank outlet 32 ​​at the bottom; a chromatographic column cavity 33 is formed in the chromatographic column 6, with a chromatographic column inlet 34 at the top and a chromatographic column outlet 35 at the bottom; each second valve port 27 is used to connect to a liquid storage tank 36, and the first valve port 26 is used to connect to the pump body inlet 24; the third valve port 28 is used to connect to the pump body outlet 25, and each fourth valve port 29 can be used to connect to a displacement liquid inlet 31, and at this time, the homogenizing tank outlet 32 ​​of the corresponding homogenizing tank 5 is used to connect to a chromatographic column inlet 34, so that the column loading operation (such as Figure 6 As shown), each fourth valve port 29 can also be used to connect to a chromatographic column inlet 34, so as to activate the chromatographic column 6 (as shown in FIG. Figure 7 As shown), each fourth valve port 29 can also be used to connect to a liquid storage tank 36 and can be used for liquid line cleaning.

[0049] A third liquid circuit switching valve 46 and a fourth liquid circuit switching valve 47 can also be installed on the warehouse wall 7 between the pipeline connection warehouse 3 and the electrical warehouse 4 through the cooperation of the installation port 8 and the mounting frame 9; an air overflow port 37 is also passed through the top of the homogenization tank 5; the third liquid circuit switching valve 46 has a fifth valve port 38 and multiple sixth valve ports 39, and is used to switch the fifth valve port 38 to one of the sixth valve ports 39; the fourth liquid circuit switching valve 47 has a seventh valve port 40 and multiple eighth valve ports 41, and is used to switch the seventh valve port 40 to one of the eighth valve ports 41; the fifth valve port 38 is used to connect to the seventh valve port 40, at least one of the eighth valve ports 41 is blocked, and each of the remaining eighth valve ports 41 is used to connect to a liquid storage tank 36, and each sixth valve port 39 can be used to connect to a chromatographic column liquid outlet 35. At this time, the chromatographic column liquid inlet 34 is connected to the fourth valve port 29, and the activation operation of the chromatographic column 6 can be carried out (such as Figure 8 As shown), each sixth valve port 39 can also be used to connect to a fourth valve port 29, and at this time, the liquid path cleaning operation can be performed (as shown in FIG. Fig. 9 As shown in FIG. 1 , each sixth valve port 39 can also be used to connect to an air overflow port 37. At this time, liquid is introduced into the displacement liquid inlet 31 through the fourth valve port 29, so that before column loading, the gas in the homogenization tank 5 can be discharged through the air overflow port 37, and then the fourth liquid circuit switching valve 47 is switched to the blocked eighth valve port 41, and then column loading is performed (as shown in FIG. 1 ). Fig.10 , Fig.11 shown).

[0050] The above description is only a preferred embodiment of the present utility model and is not a limitation on the design of the present case. Any equivalent changes made based on the key design of the present case shall fall within the protection scope of the present case.

Claims

1. An automatic column loading machine, characterized in that: The machine comprises a chassis (1), wherein the chassis (1) is divided into a column loading compartment (2), a pipeline connection compartment (3) and an electrical compartment (4); The column loading chamber (2) is provided with a plurality of homogenizing tanks (5) and a plurality of chromatographic columns (6) for detachable installation. A plurality of installation openings (8) are provided on a chamber wall (7) between a pipeline connection chamber (3) and an electrical chamber (4). Each installation opening (8) is used for detachable installation and fixation of a mounting frame (9). Each mounting frame (9) is used for installation of a liquid circuit switching valve (10) or a pump body (11). After the mounting frame (9) is installed in the installation opening (8), the position of the liquid circuit switching valve (10) or the pump body (11) thereon for connecting the pipeline is located in the pipeline connection chamber (3), and the position for electrically connecting the wire is located in the electrical chamber (4).

2. An automatic column loading machine as claimed in claim 1, characterized in that: The bottoms of the column loading bin (2) and the pipeline connection bin (3) are respectively provided with liquid receiving grooves (12), and the liquid receiving grooves (12) are capable of receiving liquid dripping from above.

3. An automatic column loading machine as claimed in claim 2, characterized in that: A liquid level sensor (13) is installed in the liquid receiving tank (12).

4. An automatic column loading machine as claimed in claim 1, characterized in that: A plurality of C-shaped elastic claws (14) are arranged on the inner side wall of the column packing bin (2), and the C-shaped elastic claws (14) are used for inserting the chromatographic column (6) to clamp the chromatographic column (6), thereby enabling the chromatographic column (6) to be detachably installed in the column packing bin (2).

5. An automatic column loading machine as claimed in claim 1, characterized in that: A plurality of clamps (15) are arranged on the inner side wall of the column loading bin (2), and the clamps (15) are used to clamp and fix or loosen the homogenizing tank (5), thereby allowing the homogenizing tank (5) to be detachably installed in the column loading bin (2).

6. An automatic column loading machine as claimed in claim 1, characterized in that: A first pipeline through-hole (16) is provided between the column loading bin (2) and the pipeline connection bin (3), and a second pipeline through-hole (17) connected to the outside of the chassis (1) is provided in the pipeline connection bin (3).

7. An automatic column loading machine as claimed in claim 1, characterized in that: A power source (18) and a control panel (19) are installed in the electrical compartment (4), and the power source (18), the control panel (19), the pump body (11) and the liquid path switching valve (10) are electrically connected.

8. An automatic column loading machine as claimed in claim 7, characterized in that: The outer wall of the chassis (1) is formed with a pipeline connection compartment opening (20) at a position corresponding to the pipeline connection compartment (3); a panel (21) is pivotally connected to a side edge of the pipeline connection compartment opening (20); a touch screen (23) is provided on the panel (21); and the touch screen (23) is electrically connected to the control panel (19).

9. An automatic column loading machine as claimed in claim 1, characterized in that: A pump body (11), a first liquid circuit switching valve (44) and a second liquid circuit switching valve (45) are installed on the chamber wall (7) between the pipeline connection chamber (3) and the electrical chamber (4) through the cooperation of the installation opening (8) and the installation frame (9); The pump body (11) has a pump body liquid inlet (24) and a pump body liquid outlet (25), and the pump body (11) is used to pump liquid from the pump body liquid inlet (24) to the pump body liquid outlet (25); The first liquid path switching valve (44) has a first valve port (26) and a plurality of second valve ports (27), and is used to switch the first valve port (26) to one of the second valve ports (27); The second liquid path switching valve (45) has a third valve port (28) and a plurality of fourth valve ports (29), and is used to switch the third valve port (28) to one of the fourth valve ports (29); A homogenizing tank inner cavity (30) is formed in the homogenizing tank (5), a displacement liquid inlet (31) is penetrated at the top end, and a homogenizing tank liquid outlet (32) is penetrated at the bottom end; A chromatographic column inner cavity (33) is formed in the chromatographic column (6), a chromatographic column liquid inlet (34) is penetrated at the top end, and a chromatographic column liquid outlet (35) is penetrated at the bottom end; Each second valve port (27) is used to communicate with a liquid storage tank (36), and the first valve port (26) is used to communicate with the liquid inlet (24) of the pump body; The third valve port (28) is used to connect to the pump body liquid outlet (25), and each fourth valve port (29) is used to connect to a displacement fluid inlet (31), or a chromatographic column liquid inlet (34), or a liquid storage tank (36). When the fourth valve port (29) is used to connect to the displacement fluid inlet (31), the homogenizing tank liquid outlet (32) of the corresponding homogenizing tank (5) is used to connect to a chromatographic column liquid inlet (34).

10. An automatic column loading machine as claimed in claim 9, characterized in that: A third liquid circuit switching valve (46) and a fourth liquid circuit switching valve (47) are also installed on the chamber wall (7) between the pipeline connection chamber (3) and the electrical chamber (4) through the cooperation of the installation opening (8) and the installation frame (9); The top of the homogenizing tank (5) is also penetrated by an air overflow port (37); The third liquid path switching valve (46) has a fifth valve port (38) and a plurality of sixth valve ports (39), and is used to switch the fifth valve port (38) to one of the sixth valve ports (39); The fourth liquid path switching valve (47) has a seventh valve port (40) and a plurality of eighth valve ports (41), and is used to switch the seventh valve port (40) to one of the eighth valve ports (41); Each sixth valve port (39) is used to connect to an air overflow port (37), or a chromatographic column liquid outlet (35), or a fourth valve port (29); the fifth valve port (38) is used to connect to the seventh valve port (40); at least one of the eighth valve ports (41) is blocked; and each of the remaining eighth valve ports (41) is used to connect to a liquid storage tank (36).

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