Mould for semi-automatically producing freeze-drying balls

Abstract

The utility model discloses a mould for semi-automatically producing freeze-drying balls, which comprises a ball-making assembly, a tray assembly, a demoulding assembly and a packaging assembly, a lower template and an upper template of the ball-making assembly for completing ball-making are separated, the freeze-drying balls are connected with the upper template, penicillin bottles are arranged in the tray assembly, and the demoulding assembly is connected with the packaging assembly. The upper mold plate connected with the freeze-drying balls is placed between the demolding assembly and the tray assembly, demolding is conducted through light pressing, the freeze-drying balls fall into the penicillin bottles, and the packaging assembly is arranged above the tray assembly where bottling is completed to package the penicillin bottles; the die has the advantages that the production and packaging process is completed through a whole set of die, 24-hour uninterrupted production of the freeze dryer can be met only through 2-3 sets of dies, and the efficiency is improved; by arranging the structure of the lower part and the upper part, a reagent or liquid medicine slightly overflows out of the bottom end of the horn-shaped opening of the upper part, a small conical boss is formed above the freeze-drying ball after freezing and is connected with the upper mold plate, the conical boss is broken during demolding, the surface of the freeze-drying ball is smooth, and the appearance is hardly influenced.

Description

Technical Field

[0001] The utility model relates to the technical field of freeze-dried ball production, in particular to a mold for semi-automatic production of freeze-dried balls. Background Art

[0002] Freeze-dried beads refer to reagents or liquid medicines that are pumped into liquid nitrogen through a professional precision micropump, so that they are quickly frozen into small solid spheres with uniform and regular shapes at an extremely short and low temperature, and then collected in a vial and placed in a freeze-drying device for frozen storage. Freeze-dried bead technology can maintain the activity of enzymes / proteins, and the freeze-dried beads have a loose mesh structure and can be quickly reconstituted. Freeze-dried bead technology can convert unstable chemical reagents into high-quality, stable, and quantitative freeze-dried beads, which is convenient for the storage and transportation of drugs and is a popular technology. At present, the main method for small-scale production of freeze-dried bead products is manual demoulding and bottling of silicone molds. This production method is inefficient and wastes a lot of manpower. In addition, the freeze-dried balls produced by silicone molds have obvious bulges on the surface and do not meet the standards for market sales. Utility Model Content

[0003] The technical problem to be solved by the utility model is that the existing freeze-dried balls have low production efficiency and their appearance does not meet the standards for sale in the market. In view of the above problems, a semi-automatic mold for producing freeze-dried balls is proposed, comprising a ball-making component, a tray component, a demoulding component and a packaging component. The lower template and the upper template of the ball-making component that complete ball making are separated, the demoulding component is arranged above the separated upper template to demould the freeze-dried balls, the tray component is arranged below the upper template to bottle the freeze-dried balls, and the packaging component is arranged above the tray component that completes bottling for packaging. The upper surface of the lower template is provided with a lower part, the lower surface of the upper template is provided with an upper part, the upper part is plugged into the lower part, the upper mold fixing plate is arranged on the upper surface of the upper template, the upper mold fixing plate is provided with a drip hole, and handles are provided on both sides of the lower template and the upper template.

[0004] The technical solution of the utility model forms a complete set of molds by arranging the structures of a ball making component, a tray component, a demoulding component and a packaging component. Only 2-3 sets of molds are needed to meet the 24-hour uninterrupted production of the freeze dryer, thereby greatly improving the efficiency of production and subsequent demoulding and packaging. By arranging the structure of the lower part and the upper part, the reagent or the medicine solution slightly overflows the bottom end of the trumpet-shaped opening, so that after freezing, a small conical boss is formed above the freeze-dried ball to connect to the upper template. After demoulding, the conical boss breaks, the surface of the freeze-dried ball is smooth, and there is almost no effect on the appearance.

[0005] Preferably, positioning blocks are provided on both sides of the lower template, the positioning blocks extend upward, and an array of lower part mounting holes is provided on the upper surface of the lower template. The lower part is arranged in the lower part mounting hole and is fixed from the bottom of the lower template by screws; the upper template is provided with a positioning groove matching the positioning blocks, and an upper part mounting hole is provided in the upper template array. The upper part is arranged in the upper part mounting hole. The positioning blocks facilitate the installation of the lower template and the upper template. After the lower part and the upper part are plugged in, a spherical cavity is formed in the middle, and they are fixed from the bottom by screws, which will not damage the spherical cavity and affect the surface flatness of the freeze-dried ball.

[0006] Preferably, a hemispherical cavity is provided on the upper part of the lower part, a matching hemispherical cavity is provided on the lower part of the upper part, the lower part and the upper part are plugged into a spherical cavity, a trumpet-shaped opening is provided on the upper part of the upper part to communicate with the hemispherical cavity on the lower part, the reagent or liquid medicine flows into the spherical cavity from the trumpet-shaped opening of the upper part and gradually fills it, the reagent or liquid medicine slightly overflows the bottom end of the trumpet-shaped opening, so that after freezing, a small conical boss is formed above the sphere to connect to the upper template, and the freeze-dried ball will not fall off directly after the upper template is separated from the lower template.

[0007] Preferably, the lower part mounting hole corresponds to the upper part mounting hole one by one and is located directly below the dripping hole. The reagent or liquid medicine falls from the dripping hole, passes through the trumpet-shaped opening of the upper part, and enters the spherical cavity.

[0008] Preferably, the tray assembly includes a tray body, an opening is arranged at the top of the tray body, a card slot is arranged at the bottom of the tray body, a bottom plate is connected to the bottom of the tray body through the card slot, a partition plate is arranged inside the tray body, the vial is arranged in the cavity separated by the partition plate, the mouth of the vial is located directly below the opening, the vial is installed from the bottom of the tray body, and is evenly arranged in the cavity separated by the partition plate, corresponding one to one with the upper parts, to receive the freeze-dried balls dropped during demolding.

[0009] Preferably, the side walls of the tray body are provided with handles for facilitating the transfer of the tray assembly.

[0010] Preferably, the demoulding assembly comprises a demoulding plate, the bottom of which is provided with a top block, which is used to push out the freeze-dried balls, so that the freeze-dried balls fall off the upper template and fall into the vial.

[0011] Preferably, the packaging assembly comprises a packaging top plate, a protrusion is provided on the lower surface of the packaging top plate, a bottle stopper clamp is provided below the packaging top plate, a bottle stopper clamping plate is provided with a bottle stopper clamping groove, the bottle stopper is clamped into the bottle stopper clamping groove, the bottle stopper clamping groove on the bottle stopper clamping plate is used for clamping the bottle stopper, and the protrusion under the packaging top plate is used for ejecting the bottle stopper and clamping it into the mouth of the syringe bottle for packaging.

[0012] Preferably, the cross-sectional shape of the protrusion is consistent with the shape of the bottle stopper slot, and the bottle stopper is slightly larger than the bottle stopper slot. Through the toughness of the bottle stopper, it is slightly deformed and then snapped into the bottle stopper slot, and will not fall off automatically due to gravity.

[0013] Compared with the prior art, the utility model has the following beneficial effects:

[0014] The technical solution of the utility model forms a complete set of molds by arranging the structures of a ball making component, a tray component, a demoulding component and a packaging component. Only 2-3 sets of molds are needed to meet the 24-hour uninterrupted production of the freeze dryer, thereby greatly improving the efficiency of production and subsequent demoulding and packaging. By arranging the structure of the lower part and the upper part, the reagent or the medicine solution slightly overflows the bottom end of the trumpet-shaped opening, so that after freezing, a small conical boss is formed above the freeze-dried ball to connect to the upper template. After demoulding, the conical boss breaks, the surface of the freeze-dried ball is smooth, and there is almost no effect on the appearance. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 It is a schematic diagram of the explosion structure of the ball making component of the utility model;

[0016] Figure 2 It is an enlarged schematic cross-sectional view of the ball-making assembly of the utility model;

[0017] Figure 3 It is a schematic diagram of the structure explosion of the tray assembly of the utility model;

[0018] Figure 4 It is a three-dimensional schematic diagram of the demoulding component of the utility model;

[0019] Figure 5 It is a schematic diagram of the structure explosion of the packaging component of the utility model;

[0020] Among them: 1-ball making assembly, 11-lower template, 12-upper template, 13-upper mold fixing plate, 14-lower part, 15-upper part, 16-positioning block, 17-lower part mounting hole, 18-upper part mounting hole, 19-drip hole, 2-tray assembly, 21-tray body, 22-bottom plate, 23-card slot, 24-partition plate, 25-syringa bottle, 3-mold removal assembly, 31-mold removal plate, 32-top block, 4-packaging assembly, 41-packaging top plate, 42-bump, 43-bottle stopper plate, 44-bottle stopper slot, 45-bottle stopper, 5-handle. DETAILED DESCRIPTION

[0021] The following will be combined with the attached embodiment of the present utility model Figure 1-5 , the technical solutions in the embodiments of the utility model are described in detail. Example 1

[0022] like Figure 1-5 As shown, the utility model is a mold for semi-automatic production of freeze-dried balls, including a ball-making component 1, a tray component 2, a demoulding component 3 and a packaging component 4. The lower template 11 and the upper template 12 of the ball-making component 1 can be separated. The upper template 12 after ball making is placed between the tray component 2 and the demoulding component 3. The demoulding component 3 is lightly pressed to separate the freeze-dried ball from the upper template 12 and drop it into the vial 25 of the tray component 2, and then the tray component 2 is placed under the packaging component 4 to package the vial.

[0023] like Figure 1-2 As shown, the ball making component 1 includes a lower template 11, and the upper surface of the lower template 11 is concave to form a plurality of lower part mounting holes 17, and the lower part mounting holes 17 are arranged in an array, and the lower part 14 is placed in the lower part mounting hole 17, and the lower part 14 is fixed in the lower part mounting hole 17 from the bottom of the lower template 11 by screws, and the screws are preferably mushroom screws, and the upper part of the lower part 14 is concave to form a hemispherical cavity, and the mushroom screws will not enter the cavity when fixed, and the two sides of the lower template 11 are fixed with bolt positioning blocks 16, and the bottom of the positioning blocks 16 is flush with the lower template 11 and extends upward.

[0024] The upper template 12 is concave to form an upper part mounting hole 18, and the upper part mounting hole 18 is through and arranged in an array. The upper part mounting hole 18 is larger at the top and smaller at the bottom, and the upper part 15 is smaller at the bottom and larger at the top. The upper part 15 is placed in the upper part mounting hole 18 and is stuck and will not fall off. The lower part of the upper part 15 is concave to form a hemispherical cavity, and the upper part of the upper part 15 is concave to form a trumpet-shaped opening. The trumpet-shaped opening is larger at the top and smaller at the bottom, and is connected to the hemispherical cavity at the bottom of the upper part 15. The two sides of the upper template 12 are concave to form positioning grooves matching the positioning blocks 16. The upper mold fixing plate 13 is fixed to the upper surface of the upper template 11 by bolts. The upper mold fixing plate 13 is concave to form a plurality of drip holes 19, and the drip holes 19 are arranged in an array.

[0025] The upper part 15 is inserted into the lower part 14, and the hemispherical cavities of the upper part 15 and the lower part 14 form a complete spherical cavity. The drip hole 19 is located directly above the upper part 15, and the drip hole 19 is slightly smaller than the outer contour of the upper part 15. Therefore, when the upper mold fixing plate 13 is fixed and the upper part 15 and the lower part 14 are completed, the upper part 15 will be stuck by the drip hole 19 and cannot be detached, which facilitates the completion of the plug-in process. The handle 5 is fixed on both sides of the lower template 11 and the upper template 12 by bolts. The handle 5 is convenient for manual transportation and can be placed in a freeze dryer for freeze drying or oven drying.

[0026] When making balls, the reagent or liquid medicine flows into the spherical cavity from the trumpet-shaped opening of the upper part 15 and gradually fills the spherical cavity. The reagent or liquid medicine slightly overflows the bottom end of the trumpet-shaped opening. Therefore, after freezing, a small conical boss is formed above the sphere, which clamps the freeze-dried ball on the upper part 15 below the upper template 12. When demolding, after being baked in an oven at 60°C for about 30 seconds, the contact parts of the freeze-dried ball with the lower template 11 and the upper template 12 are slightly melted, but the strength is still enough to carry the freeze-dried ball. In this way, after the upper template 12 is separated from the lower template 11, the freeze-dried ball will not fall off directly from the upper template 12, and it is also convenient for subsequent demolding through the demolding assembly 3. After testing, the conical boss has little effect on the appearance of the freeze-dried ball, and the appearance is much better than that of manual demolding of the silicone mold, which can meet the market standards.

[0027] like Figure 3 As shown, the tray assembly 2 includes a tray body 21, the interior of the tray body 21 is evenly divided into a plurality of cavities by a partition plate 24, and is used to place a vial 25 for storing freeze-dried balls. The vial 25 is inserted from the bottom of the tray body 21 and fixed on the tray body 21 by snapping. The upper surface of the tray body 21 is concave to form an opening, and the opening is located directly above the bottle mouth of the vial 25. The bottom of the tray body 21 is concave to form a slot 23, and the bottom plate 22 is inserted into the slot 23 to close the bottom of the tray body 21 to prevent the vial from falling.

[0028] The number and positions of the vials 21 match those of the ball-making assembly 1 . The handles 5 are fixed to the side walls of the tray body 21 of the tray assembly 2 by bolts, so as to facilitate manual transportation of the tray assembly 2 .

[0029] like Figure 4 As shown, the demoulding assembly 3 includes a demoulding plate 31, the bottom of which is convex to form a top block 32 for ejecting the freeze-dried balls. The shape of the top block 32 matches the trumpet-shaped opening of the upper part 15, and the lowest end of the top block 32 extends downward by a certain length to ensure that the freeze-dried balls can be ejected from the upper part.

[0030] When demolding, put the ball making component 1 into an oven at 60°C for about 30 seconds and then take it out. Separate the upper template 12 through the handle 5 and place it above the tray component 2 containing the vial 25 so that the freeze-dried ball is directly above the bottle mouth of the vial 25. Then place the demolding component 3 above the upper template 12 so that the top block 32 faces downward and corresponds to the drip hole 19. Lightly press the demolding component 3 so that the top block 32 breaks the conical boss on the freeze-dried ball. The freeze-dried ball is separated from the upper template 12 and falls into the vial 25 of the tray component 2.

[0031] like Figure 5As shown, the packaging component 4 includes a packaging top plate 41, the lower surface of which is convexly provided with a protrusion 42, and a bottle plug clamping plate 43 is provided below the packaging top plate 41, the bottle plug clamping plate 43 is separated from the packaging top plate 41, and a bottle plug clamping groove 44 is concavely provided on the bottle plug clamping plate 43, and the bottle plug 45 is clamped into the bottle plug clamping groove 44, and the cross-sectional shape of the protrusion 42 is consistent with the shape of the bottle plug clamping groove 44, and the bottle plug 45 is slightly larger than the bottle plug clamping groove 44, and through the toughness of the bottle plug 45, it is slightly deformed and then clamped in the bottle plug clamping groove 44, and will not fall automatically due to gravity.

[0032] During packaging, a bottle stopper 45 is engaged with each bottle stopper slot 44 on the bottle stopper clamping plate 43, and then the entire plate is placed on top of the bottled tray assembly 2, so that the bottle stoppers 45 correspond one-to-one with the vials 25 in the tray assembly 2. Then the packaging top plate 41 is placed on top of the bottle stopper clamping plate 43, so that the protrusions 42 and the bottle stoppers 45 correspond one-to-one. The packaging top plate 41 is lightly pressed, and the bottle stoppers 45 are disengaged from the bottle stopper slots 44 and clamped in a suitable position at the mouth of the vial 25. The gas is extracted to form a vacuum, and the packaging process is completed.

[0033] The cooperation of the whole set of molds including the ball making component 1, the tray component 2, the demoulding component 3 and the packaging component 4 can save manpower and improve efficiency. Only 2-3 sets of molds are needed to meet the 24-hour uninterrupted production of the freeze dryer. When the production is stopped and the mold needs to be cleaned, it is soaked in industrial alcohol for 10 minutes and cleaned. After completion, it is placed in an oven at 60°C for 10 minutes.

[0034] A method for using a mold for semi-automatic production of freeze-dried balls in this embodiment is as follows:

[0035] The ball making process is as follows: first assemble the ball making component 1, then drip the reagent or liquid medicine from the drip hole 19 through the drip irrigation machine, and finally flow into the spherical cavity formed by the lower part 14 and the upper part 15 through the trumpet-shaped opening at the top of the upper part 15, and gradually fill the spherical cavity. The reagent or liquid medicine slightly overflows the bottom end of the trumpet-shaped opening, and then the ball making component 1 is placed in a liquid nitrogen tank for liquid nitrogen freezing and rapid molding, and the ball making process of the freeze-dried ball is completed.

[0036] The demolding process is as follows: first, put the ball-making component 1 as a whole into an oven at 60°C for about 30 seconds and then take it out. The upper template 11 and the lower template 12 of the ball-making component 1 can be easily separated, and because the reagent or liquid medicine slightly overflows the bottom end of the trumpet-shaped opening, a small conical boss is formed above the sphere after freezing. The freeze-dried ball is clamped on the upper part 15 below the upper template 12, and the upper template 12 is placed on top of the assembled tray assembly 2 so that the freeze-dried ball is located directly above the mouth of the vial 25. Then, the demolding component 3 is placed on top of the upper template 12 so that the top block 32 faces downward and extends into the trumpet-shaped opening of the upper part 5. The demolding component 3 is lightly pressed, and the top block 32 breaks the conical boss on the freeze-dried ball. The freeze-dried ball is separated from the upper template 12 and falls into the vial 25 of the tray assembly 2.

[0037] The packaging process is as follows: first, a bottle stopper 45 is inserted into each bottle stopper slot 44 on the bottle stopper card plate 43, and then the bottle stopper card plate 43 is placed on the demolded tray assembly 2, so that the bottle stopper 45 corresponds one-to-one with the vial 25 in the tray assembly 2, and then the packaging top plate 41 is placed on the bottle stopper card plate 43, so that the protrusion 42 and the bottle stopper 45 correspond one-to-one, and the packaging top plate 41 is lightly pressed, and the bottle stopper 45 is disengaged from the bottle stopper slot 44 and stuck in a suitable position at the mouth of the vial 25 to facilitate the extraction of gas to form a vacuum. The bottle stopper packaging is completed, and finally the tray assembly 2 is placed in a freeze dryer for freeze drying for 22 hours. The freeze drying process is completed, and the production process of freeze-dried balls is completed.

[0038] The above embodiments are only for illustrating the technical idea of ​​the present utility model, and cannot be used to limit the protection scope of the present utility model. Any changes made on the basis of the technical solution in accordance with the technical idea proposed by the present utility model shall fall within the protection scope of the present utility model.

Claims

1. A mold for semi-automatic production of freeze-dried balls, characterized in that: The invention comprises a ball making component (1), a tray component (2), a demoulding component (3) and a packaging component (4); the lower template (11) and the upper template (12) of the ball making component (1) are separated after ball making is completed; the demoulding component (3) is arranged above the separated upper template (12) to demould the freeze-dried balls; the tray component (2) is arranged below the upper template (12) to bottle the freeze-dried balls; the packaging component (4) is arranged above the tray component (2) after bottling is completed to package; the upper surface of the lower template (11) is provided with a lower part (14); the lower surface of the upper template (12) is provided with an upper part (15); the upper part (15) is inserted into the lower part (14); the upper mold fixing plate (13) is arranged on the upper surface of the upper template (12); the upper mold fixing plate (13) is provided with a dripping hole (19); and handles (5) are provided on both sides of the lower template (11) and the upper template (12).

2. A mold for semi-automatic production of freeze-dried balls according to claim 1, characterized in that: Positioning blocks (16) are provided on both sides of the lower template (11), the positioning blocks (16) extending upwards, and lower part mounting holes (17) are provided in an array on the upper surface of the lower template (11), and the lower part (14) is arranged in the lower part mounting hole (17) and is fixed from the bottom of the lower template (11) by screws; the upper template (12) is provided with positioning grooves matching the positioning blocks (16), and the upper template (12) is provided with upper part mounting holes (18) in an array, and the upper part (15) is arranged in the upper part mounting hole (18).

3. A mold for semi-automatic production of freeze-dried balls according to claim 1, characterized in that: The upper portion of the lower part (14) is provided with a hemispherical cavity, the lower portion of the upper part (15) is provided with a matching hemispherical cavity, the lower part (14) and the upper part (15) are plugged together to form a spherical cavity, and the upper portion of the upper part (15) is provided with a trumpet-shaped opening that communicates with the hemispherical cavity at the lower portion.

4. A mold for semi-automatic production of freeze-dried balls according to claim 2, characterized in that: The lower part mounting hole (17) corresponds to the upper part mounting hole (18) one by one and is located directly below the drip hole (19).

5. The mold for semi-automatic production of freeze-dried balls according to claim 1, characterized in that: The tray assembly (2) comprises a tray body (21), the top of the tray body (21) is provided with an opening, the bottom of the tray body (21) is provided with a slot (23), the bottom plate (22) is snap-connected to the bottom of the tray body (21) via the slot (23), a partition plate (24) is provided inside the tray body (21), the vial (25) is arranged in a cavity separated by the partition plate (24), and the mouth of the vial (25) is located directly below the opening.

6. A mold for semi-automatic production of freeze-dried balls according to claim 5, characterized in that: Handles (5) are provided on both side walls of the tray body (21).

7. The mold for semi-automatic production of freeze-dried balls according to claim 1, characterized in that: The demoulding assembly (3) comprises a demoulding plate (31), and a top block (32) is provided at the bottom of the demoulding plate (31).

8. The mold for semi-automatic production of freeze-dried balls according to claim 1, characterized in that: The packaging assembly (4) comprises a packaging top plate (41), a protrusion (42) being provided on the lower surface of the packaging top plate (41), a bottle plug clamping plate (43) being provided below the packaging top plate (41), a bottle plug clamping groove (44) being provided on the bottle plug clamping plate (43), and a bottle plug (45) being clamped into the bottle plug clamping groove (44).

9. A mold for semi-automatic production of freeze-dried balls according to claim 8, characterized in that: The cross-sectional shape of the protrusion (42) is consistent with the shape of the bottle plug slot (44), and the bottle plug (45) is slightly larger than the bottle plug slot (44).

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