Ultrasonic crystallization kettle for folic acid production

Abstract

The utility model discloses an ultrasonic crystallization kettle for folic acid production. The ultrasonic crystallization kettle comprises a crystallization kettle tank body, and a top cover, an ultrasonic power supply, an ultrasonic vibration rod and a power supply device which are arranged at the top of the crystallization kettle tank body, the ultrasonic crystallization kettle comprises at least two ultrasonic vibration rods, and the ultrasonic vibration rods are arranged in the scraper and are connected with an ultrasonic power supply through signal lines; the ultrasonic power supply and the power supply device are arranged in the top cover, the power supply device comprises a control switch and a metal ring piece, and the ultrasonic power supply further comprises a metal elastic piece; the elastic sheet is in contact with the metal ring sheet; the reaction kettle comprises a stirrer for mixing materials, and the stirrer is used for stirring the materials in the reaction kettle; a high-heat-conduction ceramic layer is arranged in the crystallizing tank body, an interlayer is arranged between the high-heat-conduction ceramic layer and the side wall of the crystallizing kettle tank body, and a heat-conduction liquid inlet and a heat-conduction liquid outlet are formed in a cavity of the interlayer. According to the crystallization kettle disclosed by the invention, the particle size distribution of crystallized chemical raw material particles is more uniform.

Description

Technical Field

[0001] This utility model relates to the field of crystallization reactor technology, specifically to an ultrasonic crystallization reactor for folic acid production. Background Technology

[0002] 6S-5-methyltetrahydrofolate calcium is inherently very unstable, making it unsuitable for commercial application in the pharmaceutical and food industries. Therefore, only by crystallizing 6S-5-methyltetrahydrofolate calcium can the regular arrangement of its hydrophobic and hydrophilic layers at the molecular level, utilizing lattice energy, resist the attack of water and oxygen, thus significantly increasing its stability. Ultrasonic technology has been widely applied in chemical, food, biological, and pharmaceutical fields. It can achieve unique technical effects during crystallization. For example, in the crystallization process of supersaturated solutions, continuous ultrasonic treatment generates numerous crystal nuclei, leading to the formation of small crystals and shortening the crystallization time. Furthermore, applying ultrasound during crystallization can effectively inhibit agglomeration.

[0003] In actual production, ultrasonic technology has unique significance for the crystallization of 6S-5-methyltetrahydrofolate calcium. Normally, conventional crystallization methods for 6S-5-methyltetrahydrofolate calcium produce crystal forms I and II. These crystal forms contain water of crystallization in addition to the 6S-5-methyltetrahydrofolate calcium molecules. This small water of crystallization fills the spaces between crystal structures, resisting oxidation and increasing stability. The fewer the "small cavities" inside the crystal, the better the stability, theoretically. The cavitation effect generated by ultrasound can reduce the solubility of gases in liquids. However, currently, most ultrasonic reactors are installed outside the crystallization vessel. After passing through the heat exchange medium and multiple layers of loss on the reactor wall, the energy of the ultrasound waves reaching the material inside the reactor becomes very low. Furthermore, the ultrasonic energy beam cannot be uniformly applied to the solution. Material tends to crystallize first at the vessel wall and adhere to it, severely affecting the efficiency of pharmaceutical and food processing. Summary of the Invention

[0004] The technical problem to be solved by this utility model is to provide a reasonably designed ultrasonic crystallizing kettle for folic acid production, which addresses the shortcomings of the existing technology.

[0005] To achieve the above objectives, the present invention adopts the following technical solution:

[0006] An ultrasonic crystallizer for folic acid production is characterized by comprising a crystallizer body, a top cover mounted on the top of the crystallizer tank, an ultrasonic power supply, an ultrasonic vibrator, a power supply device, a support mounted on the bottom of the crystallizer tank, and a discharge port at the bottom of the crystallizer tank. A feed inlet and a material inlet are respectively installed on both sides of the top cover. A first reducer and a second reducer are installed in the center of the top cover. A motor is mounted on the top of each reducer. The power output of the motor is driven through the power input shaft of the first reducer, and the power output of the first reducer is driven through the input shaft of the second reducer. A stirring rod is vertically mounted in the center of the top cover. The device includes a stirring rod and a circular stirring column. The stirring rod is nested inside the circular stirring column and its top end is connected to the power output end of the first reducer. The top end of the circular stirring column is connected to the power output end of the second reducer. Stirring blades are installed on the outside of the stirring rod near the top and bottom ends. A support frame is also fixedly installed on the outside of the circular stirring column near the top end. A scraper is installed on the end of the support frame away from the stirring rod. The scraper has a cavity. The ultrasonic crystallizing vessel includes at least two ultrasonic vibrating rods. The ultrasonic vibrating rods are arranged in the cavity inside the scraper. A support frame is provided at the bottom end of the scraper. The bottom support frame is connected to the bottom of the stirring rod by a bearing.

[0007] The ultrasonic vibrating rod is connected to the ultrasonic power supply via a signal line, which is located inside the support frame. The ultrasonic power supply is fixedly located inside the top cover and fixedly connected to the annular stirring column. The power supply device is located inside the top cover of the crystallizing vessel and below the ultrasonic power supply. The power supply device includes a control switch, a metal ring, and an insulating support. The metal ring is made of a highly conductive material and is located on the side of the power supply device closest to the ultrasonic power supply. Below the ultrasonic power supply is also a metal spring, which contacts the metal ring of the power supply device. The interior of the crystallizing vessel is provided with a high thermal conductivity ceramic layer, and a sandwich structure is provided between the high thermal conductivity ceramic layer and the side wall of the crystallizing vessel. The sandwich cavity has an inlet and an outlet for the heat-conducting liquid.

[0008] As a preferred embodiment of the ultrasonic crystallizing vessel described in this utility model, the stirring blade has a "Π" shaped structure, and the stirring blades at the top and bottom of the stirring rod are arranged opposite to each other.

[0009] As a preferred embodiment of the ultrasonic crystallizing vessel of this utility model, a baffle is provided inside the cavity of the scraper, and the ultrasonic vibrating rods are arranged in groups according to their installation positions, with two or more ultrasonic vibrating rods arranged in parallel in each group.

[0010] In a preferred embodiment of the ultrasonic crystallizing vessel described in this utility model, the scrapers are symmetrically distributed around the stirring rod axis.

[0011] In a preferred embodiment of the ultrasonic crystallizer described in this utility model, the upper end of the ultrasonic vibrating rod is located below the liquid level in the crystallizer.

[0012] In a preferred embodiment of the ultrasonic crystallizing vessel described in this utility model, the ultrasonic power supply is an ultrasonic power supply with adjustable output power.

[0013] As a preferred embodiment of the ultrasonic crystallizer described in this utility model, a spirally coiled heating tube is also provided in the interlayer between the side walls of the crystallizer body, preferably a circular ring structure.

[0014] Compared with the prior art, the heating device of the crystallization vessel described in this utility model ensures a uniform temperature inside the crystallization vessel, effectively avoiding uneven heating. The ultrasonic vibrating rod inside the stirring baffle can directly apply ultrasonic energy to the material, avoiding energy loss. Compared with other ultrasonic crystallization vessels, the crystallization vessel provided by this utility model has a lower ultrasonic power and a more uniform ultrasonic field distribution within the material. The rotation of the ultrasonic vibrating rod inside the vessel can reduce material agglomeration on the vessel wall, increase the yield of the crystallization vessel, and improve production efficiency. Attached Figure Description

[0015] Figure 1 This is a structural diagram of the crystallization vessel described in this utility model;

[0016] Figure 2 This is a schematic diagram of the power supply device.

[0017] Figure 3 Bit Figure 1 Schematic diagram of the structure at point A in the middle.

[0018] In the diagram: 1-Crystallization vessel body, 2-Motor, 3-First reducer, 4-Second reducer, 5-Top cover, 6-Feed inlet, 7-Liquid inlet, 8-Ultrasonic power supply, 9-Power supply device, 10-Annular stirring column, 11-Stirring rod, 12-Ultrasonic signal line, 13-Stirring blade, 14-Ultrasonic vibrator, 15-High thermal conductivity ceramic tank, 16-Jacket, 17-Scraper, 18-Bracket, 19-Support frame, 20-Discharge port, 21-Power control switch, 22-Bottom support frame, 23-Metal ring, 24-Insulating support component, 25-Metal spring. Detailed Implementation

[0019] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present utility model. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments.

[0020] In the description of this utility model, it should be understood that the terms "upper", "lower", "front", "rear", "left", "right", "top", "bottom", "inner", "outer", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model.

[0021] Reference Figure 1-3An ultrasonic crystallization vessel for folic acid production includes a crystallization vessel body 1 with a top cover 5, an ultrasonic power supply 8, an ultrasonic vibrator 14, and a power supply device 9. A support 18 is installed at the bottom of the crystallization vessel body, and a discharge port 20 is opened at the bottom of the crystallization vessel body. A feed inlet 6 and a feed outlet 7 for adding materials are respectively installed on both sides of the top cover 5. A first reducer 3 and a second reducer 4 are installed at the center of the top of the top cover 5. A motor 2 is installed on the top of the reducer 3, and the power output end of the motor 2 is driven and connected to the power input shaft of the first reducer 3. The power output end is driven and connected to the input shaft of the second reducer 4. A stirring rod 11 and an annular stirring column 10 are vertically installed in the center of the top cover 5. The stirring rod 11 is nested inside the annular stirring column 10 and its top end is driven and connected to the power output end of the first reducer 3. The top end of the annular stirring column 10 is driven and connected to the power output end of the second reducer 4. Stirring blades 13 are installed on the outside of the stirring rod 11 and near the top and bottom ends. The stirring blades 13 have a "Π" shaped structure and are arranged opposite to each other at the top and bottom ends of the stirring rod 11. A support frame 19 is fixedly installed on the outside of the annular stirring column near its top. A scraper 17 is installed at the end of the support frame away from the stirring rod. The scraper 17 has a cavity inside, and the ultrasonic vibrating rods 14 are arranged in the cavity inside the scraper 17. The ultrasonic vibrating rods 14 are arranged in groups according to their installation positions, with two ultrasonic vibrating rods 14 arranged in parallel in each group. A bottom support frame 22 is installed at the bottom end of the scraper 17, and the bottom support frame 22 is connected to the bottom of the stirring rod 11 by a bearing. The scrapers 17 are symmetrically distributed around the axis of the stirring rod. The ultrasonic vibrating rods 14 are connected to the ultrasonic power supply 8 through a signal line 12, which is located inside the support rod 19. The ultrasonic power supply 8 is fixed inside the top cover 5 and connected to the annular stirring column. The upper end of column 10 is fixedly connected. The power supply device 9 is located inside the top cover 5 and below the ultrasonic power supply 8. The power supply device 9 includes a metal ring 23 and an insulating support 24. The power supply device 9 is connected to the control switch 21 via a power line. The control switch 21 is located on the top of the top cover. The metal ring 23 is made of a highly conductive material and is located on the side of the power supply device 9 near the ultrasonic power supply 8. The ultrasonic power supply 8 is also provided with a metal spring 25, which contacts the metal ring 23 of the power supply device 9. The crystallization tank 1 is provided with a high thermal conductivity ceramic layer 15. The high thermal conductivity ceramic layer 15 and the side wall of the crystallization tank 1 are provided with a sandwich 16. The cavity of the sandwich 16 has a heat-conducting liquid inlet and outlet on both sides. In this embodiment, the ultrasonic power supply is an ultrasonic power supply with adjustable output power. The upper end of the ultrasonic vibrator 14 is located below the liquid level in the crystallization tank.

[0022] This invention places the ultrasonic vibrating rod 14 inside the crystallization vessel 1 and within the scraper. Through the use of two speed reducers, the ultrasonic vibrating rod and the stirring blade rotate at different speeds, resulting in a more uniform distribution of the ultrasonic field inside the crystallization vessel, less energy loss, and lower energy consumption. Furthermore, the ultrasonic cavitation effect acts on the inner wall of the crystallization vessel, reducing the agglomeration of crystallized material on the vessel wall, thus increasing crystallization efficiency and yield.

[0023] In this built-in rotary crystallizer, the operator adds amorphous 6S-5-methyltetrahydrofolate calcium material into the crystallizer 1 through the feed inlet 6 and the liquid inlet 7, respectively. The motor 2 is started, causing the agitator 11 and scraper 17 to rotate and stir the material, raising its temperature. The ultrasonic power is then turned on, and the uniform ultrasonic field helps the small crystal nuclei of 6S-5-methyltetrahydrofolate calcium to suspend in the solution, thus accelerating the crystallization speed. In addition, due to the cavitation effect of the ultrasound, there are fewer small cavities in the crystals of 6S-5-methyltetrahydrofolate calcium, resulting in 6S-5-methyltetrahydrofolate calcium crystals with uniform particle size.

[0024] The above description is only a preferred embodiment of the present utility model, but the protection scope of the present utility model is not limited thereto. Any equivalent substitutions or changes made by those skilled in the art within the technical scope disclosed in the present utility model, based on the technical solution and the inventive concept of the present utility model, should be included within the protection scope of the present utility model.

Claims

1. An ultrasonic crystallization kettle for folic acid production, characterized in that: The invention comprises a crystallization kettle body, a top cover installed on the top of the crystallization kettle tank body, an ultrasonic power supply, an ultrasonic vibration rod, a power supply device, and a bracket installed at the bottom of the crystallization kettle tank body, a discharge port is opened at the bottom of the crystallization kettle tank body, a feed port and a liquid inlet are respectively installed on both sides of the top cover, a first reducer and a second reducer are installed in the center of the top of the top cover, a motor is installed on the top of the reducer, the power output end of the motor is transmission-connected to the power input shaft of the first reducer, the power output end of the first reducer is transmission-connected to the power input shaft of the second reducer, a stirring rod and an annular stirring column are vertically installed in the center of the top cover, the stirring rod is nested in the inside of the annular stirring column and its top end is transmission-connected to the power output end of the first reducer, the top of the annular stirring column is transmission-connected to the power output end of the second reducer, a stirring blade is installed outside the stirring rod and near the top and bottom ends, and the annular stirring column is provided with a stirring blade. A support frame is fixedly installed on the outside of the annular stirring column near the top, and a scraper is installed on the end of the support frame away from the stirring rod. The ultrasonic vibration rod is arranged in the cavity inside the scraper, and the ultrasonic vibration rod is connected to the ultrasonic power supply through a signal line. The signal line is arranged inside the support frame, and the ultrasonic power supply is arranged inside the top cover and fixedly connected to the annular stirring column. The power supply device is arranged inside the top cover and below the ultrasonic power supply. The power supply device includes a control switch, a metal ring sheet, and an insulating support. The metal ring sheet is made of a highly conductive material. The metal ring sheet is arranged on a side of the power supply device close to the ultrasonic power supply. A metal shrapnel is also included below the ultrasonic power supply, and the metal shrapnel is in contact with the metal ring sheet of the power supply device. A high thermal conductivity ceramic layer is provided inside the crystallization kettle tank body, and an interlayer is provided between the ceramic layer and the side wall of the crystallization kettle tank body, and an inlet and an outlet for a heat transfer liquid are provided in the interlayer cavity.

2. The ultrasonic crystallization kettle for folic acid production according to claim 1, characterized in that: A support frame is arranged at the bottom end of the scraper, and a bearing of the support frame at the bottom end is connected to the bottom of the stirring rod.

3. The ultrasonic crystallization kettle for folic acid production according to claim 1, characterized in that: The stirring blades are in a "Π"-shaped structure, and the stirring blades at the top and bottom ends of the stirring rod are arranged relative to each other.

4. The ultrasonic crystallization kettle for folic acid production according to claim 1, characterized in that: A baffle is arranged in the inner cavity of the scraper, and the ultrasonic vibrating rods are arranged in groups according to the installation positions, and two or more ultrasonic vibrating rods are arranged in parallel in each group.

5. The ultrasonic crystallization kettle for folic acid production according to claim 1, characterized in that: The scrapers are symmetrically distributed around the stirring rod axis.

6. The ultrasonic crystallization kettle for folic acid production according to claim 1, characterized in that: The upper end height of the ultrasonic vibration rod is located below the working liquid level of the crystallization kettle.

7. The ultrasonic crystallization kettle for folic acid production according to claim 1, characterized in that: The ultrasonic power supply is an ultrasonic power supply with adjustable output power.

8. The ultrasonic crystallization kettle for folic acid production according to claim 1, characterized in that: A spirally wound heating tube is also arranged in the interlayer between the side walls of the crystallization kettle tank body, and the heating tube is a circular ring structure.

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