Handheld immunofluorescence analyzer

Abstract

The utility model relates to a handheld immunofluorescence analyzer which comprises a shell, a display module, a neutralizing antibody assembly and an optical detection assembly, and an insertion opening for a reagent card to be inserted is formed in the front side of the shell. The display module is arranged on the top of the shell. The neutralizing antibody assembly is located in the shell and provided with a detection groove used for bearing a reagent card, the detection groove comprises a groove bottom wall, a groove rear wall supported on the groove bottom wall and two groove side walls arranged oppositely, limiting strips are arranged on the groove side walls, the limiting strips of the two groove side walls extend oppositely, a first elastic piece is arranged on the groove bottom wall, and the first elastic piece is arranged on the groove bottom wall. A second elastic piece is arranged on one groove side wall, and the reagent card is limited between the other groove side wall and the second elastic piece in the left-right direction. And the optical detection assembly is positioned in the shell, is arranged above the neutralizing antibody assembly and is used for detecting the reagent card on the detection groove.

Description

Technical Field

[0001] This utility model relates to the field of fluorescence analyzer technology, and more specifically, to a handheld immunofluorescence analyzer. Background Technology

[0002] Immunofluorescence is a detection method that combines immunology and fluorescent labeling technology. It involves labeling known antibodies with fluorescent substances, binding the target antigen in the sample to the fluorescently labeled antibody, and then observing the fluorescence signal to achieve qualitative or quantitative analysis of the target molecule. An immunofluorescence analyzer is an automated detection device based on immunofluorescence technology, used for the rapid and accurate analysis of specific antigens or antibodies in biological samples.

[0003] Most immunofluorescence analyzers on the market are large, heavy devices with relatively fixed usage scenarios, making them inconvenient to carry and limiting their flexibility. In view of these problems, it is necessary to research a handheld immunofluorescence analyzer that is portable and can be used flexibly. Utility Model Content

[0004] The purpose of this invention is to provide a handheld immunofluorescence analyzer that is easy to carry and can be used flexibly.

[0005] To solve the above-mentioned technical problems, the present invention adopts the following technical solution.

[0006] This utility model provides a handheld immunofluorescence analyzer, comprising: a housing with a slot for inserting a reagent card on the front side; a display module located on the top of the housing; a neutralizing antibody assembly located inside the housing, the neutralizing antibody assembly having a detection slot for receiving the reagent card, the detection slot including a bottom wall, a rear wall supported on the bottom wall, and two opposing side walls, each side wall having a limiting strip extending towards each other, the bottom wall having a first elastic member that limits the reagent card vertically between the limiting strip and the first elastic member, one side wall having a second elastic member that limits the reagent card horizontally between the other side wall and the second elastic member; and an optical detection assembly located inside the housing and above the neutralizing antibody assembly for detecting the reagent card in the detection slot.

[0007] In some embodiments of this application, the neutralizing antibody component is movable back and forth within the housing; the handheld immunofluorescence analyzer further includes a camera module located within the housing and above the neutralizing antibody component, and the port, the optical detection component, and the camera module are spaced apart in the direction of movement of the neutralizing antibody component.

[0008] In some embodiments of this application, an elastic element seat is provided below the stage, and a clearance opening is provided on the bottom wall of the detection groove. The first elastic element is disposed on the elastic element seat and extends into the detection groove through the clearance opening.

[0009] In some embodiments of this application, the first elastic member has a sheet-like structure, which includes a first part, a second part, and a third part located in the detection groove. The first part is arranged horizontally, and the second and third parts are arranged inclinedly, with the inclination direction of the second part being opposite to that of the third part. The second and third parts are respectively connected to the first part, and the first part has a deformation space with the bottom wall of the detection groove.

[0010] In some embodiments of this application, the platform includes a first platform and a second platform connected to each other. The first platform is slidably connected to the linear guide rail, and the second platform is provided with a detection groove. The first platform, the linear guide rail and the driving member are all located on one side of the second platform in the left-right direction.

[0011] In some embodiments of this application, a display port is provided on the housing, and the handheld immunofluorescence analyzer also includes a circuit board, a battery assembly and a light guide column assembly located inside the housing. The battery assembly and the light guide column assembly are respectively connected to the circuit board and located on the left and right sides of the circuit board, and the light-emitting side of the light guide column is exposed to the display port.

[0012] In some embodiments of this application, a display port is provided on the housing, and the handheld immunofluorescence analyzer also includes a circuit board, a battery assembly and a light guide column assembly located inside the housing. The battery assembly and the light guide column assembly are respectively connected to the circuit board and located on the left and right sides of the circuit board, and the light-emitting side of the light guide column is exposed to the display port.

[0013] In some embodiments of this application, the handheld immunofluorescence analyzer further includes a printing module located within the housing.

[0014] In some embodiments of this application, the housing includes an upper shell and a lower shell. The lower shell has openings at its top and front. The upper shell includes a top plate and a front cover connected to each other. The top plate and the front cover are used to close the opening at the top of the lower shell and the opening at the front of the lower shell, respectively. The display module is disposed on the top plate, and the socket is located on the front cover.

[0015] As can be seen from the above technical solution, the embodiments of this utility model have at least the following advantages and positive effects:

[0016] In this embodiment of the handheld immunofluorescence analyzer, various functional components are integrated with the housing, resulting in a compact overall structure and miniaturization. This removes the limitation of use only in fixed scenarios, making it easy to carry. In practical use, inserting the reagent card into the slot allows it to be pushed into the detection slot of the neutralizing antibody component. The rear wall of the slot positions the reagent card to confirm it has been pushed into place. During the process of pushing the reagent card into the detection slot, it is effectively restrained in both vertical and horizontal directions by the combined action of the limiting strip on the side wall of the slot and the first elastic element on the bottom wall, as well as the combined action of the second elastic element on one side wall and the other side wall. This ensures the reagent card remains stable during detection by the optical detection component, reducing errors caused by vibration or movement and improving the accuracy of the detection results. On the other hand, the effective limiting of the test card by the detection slot also makes this handheld immunofluorescence analyzer suitable for handheld use. The display module is located on the top of the housing, and the insertion port is located on the front of the housing, which makes it easy to insert and remove test cards and view or operate the display module while holding the device. Therefore, this handheld immunofluorescence analyzer is not limited to operation on a fixed support platform and can be used stably and conveniently while holding the device, thereby improving the flexibility of use. Attached Figure Description

[0017] The various objectives, features, and advantages of this invention will become more apparent from the following detailed description of preferred embodiments in conjunction with the accompanying drawings. The drawings are merely illustrative illustrations of the invention and are not necessarily drawn to scale. In the drawings, the same reference numerals always denote the same or similar parts. Wherein:

[0018] Figure 1 This is a schematic diagram of a handheld immunofluorescence analyzer according to an exemplary embodiment.

[0019] Figure 2 yes Figure 1 A schematic diagram of its decomposed structure.

[0020] Figure 3 yes Figure 2 A schematic diagram of the structure after removing the top shell and reagent card.

[0021] Figure 4 yes Figure 3 The top view in the image.

[0022] The annotations in the attached figures are explained as follows:

[0023] 1. Housing; 11. Upper housing; 111. Top plate; 112. Front cover; 1121. Port; 12. Lower housing; 121. Display port;

[0024] 2. Display module;

[0025] 3. Neutralizing antibody assembly; 31. Base plate; 32. Linear guide rail; 33. Stage; 331. First carrier; 332. Second carrier; 333. Detection tank; 3331. Tank bottom wall; 3332. Tank rear wall; 3333. Tank side wall; 3334. Limiting strip; 34. Driving component; 35. First elastic element; 351. First part; 352. Second part; 353. Third part; 36. Second elastic element; 37. Elastic element seat;

[0026] 4. Optical inspection components;

[0027] 5. Camera module;

[0028] 6. Circuit board;

[0029] 7. Battery assembly;

[0030] 8. Light guide column assembly;

[0031] 9. Printing module;

[0032] 10. Reagent card. Detailed Implementation

[0033] Although the present invention can be readily embodied in various forms, only some specific embodiments are shown in the accompanying drawings and will be described in detail in this specification. It is understood that this specification should be regarded as an exemplary illustration of the principles of the present invention and is not intended to limit the present invention to what is described herein.

[0034] Therefore, a feature pointed out in this specification is used to describe one feature of one embodiment of the present invention, and does not imply that every embodiment of the present invention must have the described feature. Furthermore, it should be noted that this specification describes many features. While certain features may be combined to illustrate possible system designs, these features may also be used in other combinations not explicitly stated. Therefore, unless otherwise stated, the described combinations are not intended to be limiting.

[0035] In the embodiments shown in the accompanying drawings, the directional indications (such as up, down, left, right, front, and back) used to explain the structure and movement of the various elements of this invention are relative rather than absolute. These descriptions are appropriate when these elements are in the positions shown in the drawings. If the descriptions of the positions of these elements change, these directional indications also change accordingly.

[0036] Please see Figures 1 to 3 The handheld immunofluorescence analyzer provided in one embodiment of this utility model mainly includes a housing 1, a display module 2, a neutralizing antibody assembly 3, and an optical detection assembly 4. The front side of the housing 1 has an insertion slot 1121 for inserting a reagent card 10. The display module 2 is located on the top of the housing 1. The neutralizing antibody assembly 3 is located inside the housing 1. The neutralizing antibody assembly 3 has a detection slot 333 for receiving the reagent card 10. The detection slot 333 includes a bottom wall 3331, a rear wall 3332 supported on the bottom wall 3331, and two opposing side walls 3333. Limiting strips 3334 are provided on the side walls 3333, and the limiting strips 3334 of the two side walls 3333 extend towards each other. A first elastic member 35 is provided on the bottom wall 3331, which limits the reagent card 10 vertically between the limiting strips 3334 and the first elastic member 35. A second elastic member 36 is provided on one of the side walls 3333, which limits the reagent card 10 horizontally between the other side wall 3333 and the second elastic member 36. An optical detection assembly 4 is located inside the housing 1 and above the neutralizing antibody assembly 3, and is used to detect the reagent card 10 on the detection slot 333.

[0037] In the handheld immunofluorescence analyzer of this embodiment, by integrating various functional components with the housing 1, the overall structure is more compact, thereby achieving miniaturization of the overall structure and removing the limitation of use only in fixed scenarios, making it easy to carry. In specific use, inserting the reagent card 10 into the slot 1121 allows the reagent card 10 to be pushed into the detection slot 333 of the neutralizing antibody component 3. The rear wall 3332 of the slot is used to position the reagent card 10 to confirm that the reagent card 10 has been pushed into place. During the process of the reagent card 10 being pushed into the detection slot 333, it is subjected to the combined action of the limiting strip 3334 on the side wall 3333 of the slot and the first elastic member 35 on the bottom wall 3331 of the slot, as well as the combined action of the second elastic member 36 on one side wall 3333 and the other side wall 3333, so that the reagent card 10 can be effectively limited in the vertical and horizontal directions. On the one hand, this allows the reagent card 10 to remain stable during the detection process by the optical detection component 4, thereby reducing errors caused by vibration or movement and improving the accuracy of the detection results. On the other hand, the effective limiting of the reagent card 10 by the detection slot 333 also makes the handheld immunofluorescence analyzer suitable for handheld use. The display module 2 is located on the top of the housing 1, and the insertion port 1121 is located on the front side of the housing 1, which makes it easy to insert and remove the reagent card 10 and view or operate the display module 2 in handheld mode. Therefore, the handheld immunofluorescence analyzer is not limited to operation on a fixed support platform and can be used stably and conveniently in handheld mode, thereby improving the flexibility of use.

[0038] It is conceivable that the arrangement of the first elastic element 35 and the second elastic element 36 also enables the detection slot 333 to be applicable to the detection of different types of reagent cards 10.

[0039] Please see Figures 2 to 4 In a specific embodiment, the neutralizing antibody component 3 is movably disposed within the housing 1. The handheld immunofluorescence analyzer also includes a camera module 5, which is located within the housing 1 and positioned above the neutralizing antibody component 3. The insertion port 1121, the optical detection component 4, and the camera module 5 are spaced apart in the direction of movement of the neutralizing antibody component 3. On one hand, the back-and-forth movement of the neutralizing antibody component 3 can cause the reagent card 10 on the detection slot 333 to correspond to the optical detection component 4 and the camera module 5 respectively, so as to detect the sample on the reagent card 10 and acquire image information. On the other hand, the back-and-forth movement of the neutralizing antibody component 3 can also cause the reagent card 10 on the detection slot 333 to enter or exit the housing 1 from the insertion port 1121, thereby facilitating the removal of the reagent card 10.

[0040] In a specific embodiment, the neutralizing antibody assembly 3 includes a base plate 31, a linear guide rail 32, a stage 33, and a drive component 34. The base plate 31 is disposed on the bottom of the housing 1, the linear guide rail 32 is disposed on the base plate 31, the stage 33 is slidably connected to the linear guide rail 32, and the drive component 34 is disposed on the base plate 31 and is used to drive the stage 33 to slide relative to the linear guide rail 32. The detection slot 333 is located on the stage 33. This provides a practical and feasible implementation method for the neutralizing antibody assembly 3 to move back and forth within the housing 1. Through the design of the linear guide rail 32 and the drive component 34, the stage 33 can move precisely along the linear guide rail 32, ensuring that the reagent card 10 on the detection slot 333 can be accurately positioned below the detection assembly and the camera module 5 during the movement, thereby improving the accuracy of the detection results.

[0041] Please see Figure 3 In a specific embodiment, an elastic element seat 37 is provided below the stage 33, and a clearance opening is provided on the bottom wall 3331 of the detection groove 333. The first elastic element 35 is disposed on the elastic element seat 37 and extends into the detection groove 333 through the clearance opening. The clearance opening and the elastic element seat 37 are configured to ensure that the first elastic element 35 can be located on the bottom wall 3331 of the detection groove 333 and cooperate with the limiting strip 3334, without affecting the immunofluorescence reaction and detection of the reagent card 10 in the detection groove 333.

[0042] In a specific embodiment, the first elastic member 35 has a sheet-like structure, comprising a first portion 351, a second portion 352, and a third portion 353 located within the detection groove 333. The first portion 351 is horizontally arranged, while the second portion 352 and the third portion 353 are inclined, with the inclination direction of the second portion 352 opposite to that of the third portion 353. The second portion 352 and the third portion 353 are respectively connected to the first portion 351, providing deformation space between the first portion 351 and the bottom wall 3331 of the detection groove 333. The structural design of the first elastic member 35 can smoothly provide elastic force. The inclined structure of the second portion 352 and the third portion 353 allows the reagent card 10 to be pushed into the detection groove 333 from the insertion port 1121, and then pushed onto the first portion 351 along the slope of the second portion 352 or the third portion 353, where it is clamped between the first portion 351 and the limiting strip 3334 to achieve vertical limiting.

[0043] In this embodiment, the first elastic member 35 further includes a fourth part and a fifth part (not shown in the figures) arranged horizontally. The fourth part and the fifth part are connected to the second part 352 and the third part 353 respectively, and are sandwiched between the platform 33 and the elastic member seat 37 to fix the first elastic member 35.

[0044] It is conceivable that the second elastic element 36 can be fixed on the side wall 3333 of the detection groove 333 in the same way as the first elastic element 35 in the above embodiment, or it can be directly fixed on the side wall 3333 of the groove. The specific structure of the second elastic element 36 refers to the structure of the first elastic element 35, and will not be described in detail here.

[0045] Please see Figures 2 to 4 In a specific embodiment, the stage 33 includes a first carrier portion 331 and a second carrier portion 332 connected to each other. The first carrier portion 331 is slidably connected to the linear guide rail 32, and the second carrier portion 332 is provided with a detection groove 333. The first carrier portion 331, the linear guide rail 32, and the drive component 34 are all located on one side of the second carrier portion 332 in the left-right direction. By concentrating the drive component 34, the linear guide rail 32, and the first carrier portion 331 on one side of the second carrier portion 332, and since the detection groove 333 is located on the second carrier portion 332, the optical detection module and the camera module 5 are arranged on the same side as the second carrier portion 332. This layout can effectively save internal space, making the overall structure more compact and conducive to the miniaturization of the handheld immunofluorescence analyzer.

[0046] Please see Figures 1 to 4 In a specific embodiment, the housing 1 has a display port 121. The handheld immunofluorescence analyzer also includes a circuit board 6, a battery assembly 7, and a light guide assembly 8. The battery assembly 7 and the light guide assembly 8 are respectively connected to the circuit board 6 and located on the left and right sides of the circuit board 6, with the light-emitting side of the light guide exposed through the display port 121. The battery assembly 7 is used to supply power, providing stable power support for the device. The light guide assembly 8 is used to indicate the status for easy observation by the user. The circuit board 6, as the core control unit of the device, is used to control various components, thereby ensuring the stability and reliability of the device's operation. The battery assembly 7 and the light guide assembly 8 are located on opposite sides of the circuit board 6, which reduces mutual interference between them, improves the reliability of the device, and also makes the overall structure more compact.

[0047] In this embodiment, the housing 1 is also provided with TYPE-C, USB and LAN interfaces located on the same side as the display port 121.

[0048] Please see Figures 2 to 4 In a specific embodiment, the handheld immunofluorescence analyzer also includes a printing module 9, which is located inside the housing 1. The printing module 9 is used to print the detection structure of the reagent card 10 and the acquired image information for easy observation by the user.

[0049] Please see Figure 2In a specific embodiment, the housing 1 includes an upper shell 11 and a lower shell 12. The lower shell 12 has openings at its top and front. The upper shell 11 includes a top plate 111 and a front cover 112 connected to each other. The top plate 111 and the front cover 112 respectively close the openings at the top and front of the lower shell 12. The display module 2 is mounted on the top plate 111, and the insertion port 1121 is located on the front cover 112. The modular design of the housing 1 facilitates the assembly and maintenance of the components within the housing 1.

[0050] Although the present invention has been described with reference to several typical embodiments, it should be understood that the terminology used is descriptive and exemplary, and not restrictive. Since the present invention can be embodied in many forms without departing from the spirit or essence of the invention, it should be understood that the above embodiments are not limited to any of the foregoing details, but should be interpreted broadly within the spirit and scope defined by the appended claims. Therefore, all variations and modifications falling within the scope of the claims or their equivalents should be covered by the appended claims.

Claims

1. A hand-held immunofluorescence analyzer characterized in that, The application relates to a handheld immunofluorescence analyzer. The handheld immunofluorescence analyzer comprises a shell, a display module, a neutralizing antibody assembly and an optical detection assembly. The shell is provided with an insertion opening in the front side for inserting a reagent card. The display module is arranged on the top of the shell. The neutralizing antibody assembly is arranged in the shell and is provided with a detection groove for accommodating the reagent card.

2. The hand-held immunofluorescence analyzer of claim 1, wherein, The detection groove comprises a groove bottom wall, a groove back wall and two oppositely arranged groove side walls supported on the groove bottom wall. Limiting strips are arranged on the groove side walls and the limiting strips of the two groove side walls extend towards each other.

3. The hand-held immunofluorescence analyzer of claim 2, wherein, A first elastic member is arranged on the groove bottom wall and the reagent card is limited up and down between the limiting strips and the first elastic member.

4. The hand-held immunofluorescence analyzer of claim 3, wherein, A second elastic member is arranged on one of the groove side walls and the reagent card is limited left and right between the other groove side wall and the second elastic member.

5. The hand-held immunofluorescence analyzer according to claim 1 or 4, characterized in that, The optical detection assembly is arranged above the neutralizing antibody assembly in the shell and is used for detecting the reagent card on the detection groove.

6. The hand-held immunofluorescence analyzer of claim 3, wherein, The neutralizing antibody assembly is movably arranged in the shell. The handheld immunofluorescence analyzer further comprises a camera module arranged in the shell and above the neutralizing antibody assembly.

7. The hand-held immunofluorescence analyzer of claim 1, wherein, The insertion opening, the optical detection assembly and the camera module are arranged at intervals in the moving direction of the neutralizing antibody assembly.

8. The hand-held immunofluorescence analyzer of claim 1, wherein, The neutralizing antibody assembly comprises a bottom plate, a linear guide rail, a carrier and a driving member. The bottom plate is arranged on the bottom of the shell. The linear guide rail is arranged on the bottom plate. The carrier is slidably connected with the linear guide rail. The driving member is arranged on the bottom plate and is used for driving the carrier to slide relative to the linear guide rail. The detection groove is arranged on the carrier. An elastic member seat is arranged below the carrier. A gap is arranged on the groove bottom wall of the detection groove. The first elastic member is arranged on the elastic member seat and extends into the detection groove through the gap. The first elastic member has a sheet structure and comprises a first part, a second part and a third part. The first part is horizontally arranged. The second part and the third part are arranged in an inclined manner. The inclined directions of the second part and the third part are opposite. The second part and the third part are connected with the first part and the first part has a deformation space with the groove bottom wall of the detection groove. The carrier comprises a first carrier and a second carrier connected with each other. The first carrier is slidably connected with the linear guide rail. The second carrier is provided with the detection groove. The first carrier, the linear guide rail and the driving member are arranged on one side of the second carrier in the left-right direction. A display opening is arranged on the shell. The handheld immunofluorescence analyzer further comprises a circuit board, a battery assembly and a light guide column assembly arranged in the shell. The battery assembly and the light guide column assembly are connected with the circuit board and are arranged on the left and right sides of the circuit board. The light emitting side of the light guide column is exposed to the display opening. The handheld immunofluorescence analyzer further comprises a printing module arranged in the shell.

9. The hand-held immunofluorescence analyzer of claim 1, wherein, The shell comprises an upper shell and a lower shell, the top and front side of the lower shell are provided with openings, the upper shell comprises a top plate and a front cover connected with each other, the top plate and the front cover are used for closing the opening of the top of the lower shell and the opening of the front side of the lower shell respectively, the display module is arranged on the top plate, and the socket is arranged on the front cover.

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