Fermentation tank for extracting pyrroloquinoline quinone

By introducing a combination of rectangular tubes and temperature-controlled liquids into the fermenter, the problem of low temperature regulation efficiency in large-space culture media was solved, enabling rapid and uniform stirring and temperature control of the culture media, thereby improving the production efficiency of pyrroloquinoline quinone.

CN224091867UActive Publication Date: 2026-04-07ZHEJIANG SILVER ELEPHANT BIO ENG
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
Filing Date
2025-04-28
Publication Date
2026-04-07

AI Technical Summary

Technical Problem

Existing fermenters are inefficient at regulating the temperature of large-space culture media, which affects the production of pyrroloquinoline quinone.

Method used

The design employs a combination of rectangular tubes and temperature-controlled liquids. The rectangular tubes are used for stirring, and the temperature-controlled liquids are used to regulate the temperature of the culture medium. The impeller and central shaft are used to drive the flow of the culture medium, achieving rapid temperature regulation and uniform stirring.

Benefits of technology

This enabled rapid and uniform temperature control of the culture medium, thereby improving the production efficiency of pyrroloquinoline quinone.

✦ Generated by Eureka AI based on patent content.

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Abstract

The utility model relates to the field of fermentation, in particular to a fermentation tank for extracting pyrroloquinoline quinine, which comprises a box body and a tank body, an extension pipe is fixed at the upper end of the box body, the tank body is positioned in the box body and rotates in the extension pipe, a discharge pipe is arranged at the lower end of the tank body, a control valve is mounted on the discharge pipe and penetrates through the lower end of the box body, and the control valve is connected with the tank body. A plurality of rectangular pipes are arranged in the tank body, two ends of each rectangular pipe are communicated with the box body, and a cover plate is mounted at the upper end of the extension pipe. The rectangular pipes are vertically arranged in the tank body, and every two adjacent rectangular pipes are vertically arranged in a staggered mode. A ring body is arranged in the center of each rectangular pipe, a ring cavity is formed in each ring body, and the ring cavities are communicated with the rectangular pipes. The device can adjust the temperature of the culture solution to change quickly.
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Description

Technical Field

[0001] This utility model relates to the field of fermentation, and more specifically to a fermenter for extracting pyrroloquinoline quinone. Background Technology

[0002] Pyrroloquinoline quinone (PQQ) is reddish-brown in appearance. It decomposes easily under light, is readily soluble in water, and is highly polar. It is an aromatic ortho-quinone compound. PQQ has a wide range of applications. In the pharmaceutical and healthcare fields, it has neuroprotective effects and can be used to treat neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease by inhibiting neuronal damage and death, thus improving patients' cognitive and motor functions. It also has certain preventive and therapeutic effects on cardiovascular diseases, lowering blood lipids and blood pressure, and inhibiting the formation of atherosclerosis. In liver diseases, PQQ can protect liver cells, reduce liver damage, and has an adjunctive therapeutic effect on hepatitis and cirrhosis. In the food industry, PQQ can be added as a nutritional fortifier to foods such as milk powder, beverages, and cereal products to increase their nutritional value. Especially for special populations such as infants, pregnant women, and the elderly, PQQ supplementation helps meet their specific nutritional needs, promotes healthy development, and maintains good physical condition. In agriculture, PQQ can promote plant growth and development, increasing crop yield and quality. It can promote plant root growth, enhance the plant's ability to absorb nutrients and water, and improve the plant's resistance to adverse conditions, such as drought, salinity, and pests and diseases. Furthermore, adding PQQ to bio-fertilizers can promote the growth and reproduction of beneficial microorganisms in the soil, improve soil structure, and increase soil fertility. Simultaneously, it can enhance the symbiotic relationship between plants and microorganisms, promote the absorption and utilization of nutrients in the soil by plants, reduce the amount of chemical fertilizers used, and lower environmental pollution.

[0003] The main production methods of pyrroloquinoline quinone include chemical synthesis and microbial fermentation. When producing pyrroloquinoline quinone using microbial fermentation, it is necessary to cultivate the microbial strain in a fermenter. Existing fermenters mostly control the temperature of the culture medium by controlling the temperature of the inner wall of the fermenter body, and at the same time, they use a stirrer to stir the culture medium to ensure uniform temperature. However, when the internal space of the tank is large, it is difficult to regulate the rapid temperature change of the culture medium by stirring alone, which affects the production of pyrroloquinoline quinone. Utility Model Content

[0004] To solve the above-mentioned technical problems, this utility model provides a fermenter for the extraction of pyrroloquinoline quinone, which can adjust the temperature of the culture medium for rapid change.

[0005] The technical solution adopted by this utility model to solve the above problems is as follows:

[0006] A fermenter for extracting pyrroloquinoline quinone includes a box and a tank. An extension tube is fixed to the upper end of the box. The tank is located inside the box and rotates within the extension tube. A discharge pipe is provided at the lower end of the tank. A control valve is installed on the discharge pipe and it passes through the lower end of the box. Multiple rectangular tubes are provided inside the tank. Both ends of each rectangular tube are connected to the box. A cover plate is installed at the upper end of the extension tube.

[0007] Multiple rectangular tubes are arranged vertically inside the tank, with adjacent rectangular tubes being vertically staggered.

[0008] Each rectangular tube has a ring at its center, and the ring has a cavity that is connected to the rectangular tube.

[0009] The cover plate has a central axis that rotates through multiple rings and has an impeller fixed at its lower end.

[0010] The cover plate is equipped with an addition tube, and the upper end of the addition tube is covered with a blocking plate.

[0011] The side end of the blocking plate is fixed with a rotating shaft, which is rotatably connected to the upper end of the adding tube.

[0012] A lever is fixed to the upper end of the blocking plate.

[0013] Two connecting pipes are symmetrically arranged on the outer side of the box.

[0014] A sleeve is fixed at the lower end of the box where the discharge pipe passes through. Two partitions are symmetrically arranged on both sides of the sleeve. The two partitions are slidably connected to the outer surface of the tank and divide the internal space of the box into two. The two internal spaces are respectively connected to two connecting pipes.

[0015] The lower end of the box is fixed with multiple support legs.

[0016] The beneficial effects of this utility model are:

[0017] 1. By setting up a rectangular tube, when the transmission tank rotates, it can drive the rectangular tube to rotate, stirring the culture medium. At the same time, the temperature control liquid can enter the rectangular tube to control the temperature of the culture medium inside the culture medium.

[0018] 2. The rotation of the transmission impeller can drive the culture medium to flow vertically, which, combined with the circumferential rotation of the rectangular tube, improves the stirring efficiency. Attached Figure Description

[0019] Figure 1 and Figure 2 A schematic diagram of the overall structure of a fermenter for extracting pyrroloquinoline quinone;

[0020] Figure 3 A schematic cross-sectional view of the fermenter used for the extraction of pyrroloquinoline quinone;

[0021] Figure 4 This is a partial sectional view of the casing and sleeve.

[0022] Figure 5 This is a cross-sectional structural diagram of the tank, rectangular tube, and discharge pipe;

[0023] Figure 6 This is a schematic diagram of the cover plate and impeller structure;

[0024] Figure 7 This is a schematic diagram of the blockage plate.

[0025] In the picture:

[0026] 1. Box body; 2. Sleeve; 3. Baffle plate; 4. Connecting pipe; 5. Extension pipe; 6. Tank body; 7. Rectangular pipe; 8. Discharge pipe; 9. Ring body; 10. Cover plate; 11. Central shaft; 12. Impeller; 13. Adding pipe; 14. Rotating shaft; 15. Blocking plate. Detailed Implementation

[0027] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0028] like Figure 1-7 The fermenter used for the extraction of pyrroloquinoline quinone is shown in detail below:

[0029] A fermenter for extracting pyrroloquinoline quinone includes a box body 1 and a tank body 6. An extension pipe 5 is welded and fixed to the upper end of the box body 1. The tank body 6 is located inside the box body 1 and rotates inside the extension pipe 5. A discharge pipe 8 is welded to the lower end of the tank body 6. A control valve is installed on the discharge pipe 8 and it passes through the lower end of the box body 1. Multiple rectangular tubes 7 are welded inside the tank body 6. Both ends of each rectangular tube 7 are connected to the box body 1. A cover plate 10 is installed at the upper end of the extension pipe 5.

[0030] Because the upper end of the tank 6 is sealed and rotatably connected to the inner wall of the extension pipe 5, and the discharge pipe 8 is sealed and rotatably connected to the lower end of the box 1, a ring cavity is formed between the box 1 and the tank 6. This ring cavity is filled with temperature-controlling liquid, and the temperature of the temperature-controlling liquid is transferred to the tank 6 to regulate the temperature of the culture medium containing bacteria inside the tank 6. At the same time, through the setting of multiple rectangular tubes 7, multiple rectangular tubes 7 pass through the inside of the tank 6, and the temperature-controlling liquid is also located inside the rectangular tubes 7. The temperature of the temperature-controlling liquid can be regulated through the rectangular tubes 7 inside the culture medium to regulate the temperature of the culture medium, thereby enabling better regulation of the culture medium temperature.

[0031] Furthermore, by installing a first motor on the side of the housing 1, the transmission wheel on the discharge pipe 8 is driven, thereby driving the tank 6 to rotate inside the housing 1 through the discharge pipe 8, which in turn drives multiple rectangular tubes 7 to rotate, thereby stirring the culture medium and further achieving the purpose of rapidly adjusting the temperature change of the culture medium.

[0032] Further:

[0033] To ensure the effective stirring of the culture medium by the multiple rectangular tubes 7 as the tank 6 rotates, the multiple rectangular tubes 7 are arranged vertically inside the tank 6, with adjacent rectangular tubes 7 vertically staggered. This increases the stirring area of ​​the culture medium by the multiple rectangular tubes 7 when the tank 6 rotates, thereby ensuring stirring efficiency.

[0034] Further:

[0035] A ring 9 is provided at the center of each rectangular tube 7, and a ring cavity is provided inside the ring 9, which is connected to the rectangular tube 7.

[0036] By designing the ring 9, the contact area between the rectangular tube 7 and the culture medium is increased, and the temperature-controlled liquid in the ring cavity can transfer temperature to the culture medium more efficiently.

[0037] Further:

[0038] The cover plate 10 has a central shaft 11 that rotates through multiple rings 9 and has an impeller 12 fixed at its lower end.

[0039] The ring 9 provides space for the central shaft 11. The second motor installed on the cover plate 10 drives the central shaft 11, thereby driving the impeller 12 to rotate in the center below the tank 6. The impeller 12 consists of a central block and multiple blades arranged circumferentially on the central block. The blades are inclined so that when the impeller 12 rotates, it can push the culture medium upward. Combined with the circumferential stirring of the culture medium by the rotation of multiple rectangular tubes 7, it can better form the stirring of the culture medium and ensure the overall temperature of the culture medium is uniform.

[0040] Further:

[0041] The cover plate 10 is welded with an addition tube 13, which is used to add culture medium into the tank 6. The upper end of the addition tube 13 is covered with a plug plate 15 for sealing the port of the addition tube 13.

[0042] By welding and fixing a rotating shaft 14 to the side end of the blocking plate 15, and providing an ear plate on the upper side of the adding tube 13, the rotating shaft 14 is rotatably connected to the ear plate. Thus, by pushing the lever fixed at the upper end of the blocking plate 15, the blocking plate 15 can be rotated at the upper end of the adding tube 13 around the rotating shaft 14, thereby controlling the opening or closing of the adding tube 13.

[0043] Further:

[0044] To better control the temperature of the temperature-controlled liquid in the annular cavity, two connecting pipes 4 are symmetrically arranged on the outside of the tank 1. The two connecting pipes 4 are connected to an external temperature-controlled liquid supply system. The temperature-controlled liquid supply system can adjust the temperature of the temperature-controlled liquid and supply the temperature-controlled liquid into the annular cavity through one of the connecting pipes 4 and then return it to the temperature-controlled liquid supply system through the other connecting pipe 4, forming a circulation of the temperature-controlled liquid and ensuring precise control of the temperature of the culture medium in the tank 6.

[0045] Further:

[0046] A sleeve 2 is fixed at the lower end of the box 1 through the discharge pipe 8. The sleeve 2 is fitted onto the discharge pipe 8 and a seal is formed by a sealing ring. Two partitions 3 are symmetrically arranged on both sides of the sleeve 2. The two partitions 3 are slidably connected to the outer surface of the tank 6 and divide the internal space of the box 1 into two. The two internal spaces are respectively connected to two connecting pipes 4.

[0047] This creates an inner space for supplying the temperature-controlled liquid and another inner space for discharging the temperature-controlled liquid. This promotes the flow of the temperature-controlled liquid in the two inner spaces through the rectangular tube 7, thereby ensuring the flow of the temperature-controlled liquid in the rectangular tube 7 and ensuring that the temperature of the temperature-controlled liquid in the rectangular tube 7 is consistent with that in the annular cavity, further ensuring precise control of the temperature of the culture medium in the tank 6.

[0048] Further:

[0049] Multiple support legs are fixed at the lower end of the housing 1 to provide support for the housing 1 and to provide space for the discharge pipe 8 to discharge liquid.

[0050] Of course, the above description is not a limitation of this instruction manual, and this utility model is not limited to the examples mentioned above. Any changes, modifications, additions or substitutions made by those skilled in the art within the scope of this utility model are also within the protection scope of this utility model.

Claims

1. A fermenter for extracting pyrroloquinoline quinone, characterized in that: The device includes a box and a tank. An extension pipe is fixed to the upper end of the box. The tank is located inside the box and rotates inside the extension pipe. A discharge pipe is provided at the lower end of the tank. A control valve is installed on the discharge pipe and it passes through the lower end of the box. Multiple rectangular tubes are provided inside the tank. Both ends of each rectangular tube are connected to the box. A cover plate is installed at the upper end of the extension pipe.

2. The fermenter according to claim 1, characterized in that: Multiple rectangular tubes are arranged vertically inside the tank, with adjacent rectangular tubes being vertically staggered.

3. The fermenter according to claim 1, characterized in that: Each rectangular tube has a ring at its center, and the ring has a cavity that is connected to the rectangular tube.

4. The fermenter according to claim 3, characterized in that: The cover plate has a central axis that rotates through multiple rings and has an impeller fixed at its lower end.

5. The fermenter according to claim 3, characterized in that: The cover plate is equipped with an addition tube, and the upper end of the addition tube is covered with a blocking plate.

6. The fermenter according to claim 5, characterized in that: The side end of the blocking plate is fixed with a rotating shaft, which is rotatably connected to the upper end of the adding tube.

7. The fermenter according to claim 6, characterized in that: A lever is fixed to the upper end of the blocking plate.

8. The fermenter according to claim 1, characterized in that: Two connecting pipes are symmetrically arranged on the outer side of the box.

9. The fermenter according to claim 8, characterized in that: A sleeve is fixed at the lower end of the box where the discharge pipe passes through. Two partitions are symmetrically arranged on both sides of the sleeve. The two partitions are slidably connected to the outer surface of the tank and divide the internal space of the box into two. The two internal spaces are respectively connected to two connecting pipes.

10. The fermenter according to claim 1, characterized in that: The lower end of the box is fixed with multiple support legs.